## Fri Jan  3 20:07:07 2025
## emapper-2.1.12
## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA798446/SRR17658288/SRR17658288_p_cluster_rep_seq.fasta --output PRJNA798446_SRR17658288 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
k59_432209_1	748247.AZKH_2793	2.96e-25	99.8	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2VIMK@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Nicotinamidase	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
k59_432209_2	671143.DAMO_1019	3.09e-97	296.0	COG1488@1|root,COG1488@2|Bacteria,2NNUE@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	iYO844.BSU31750	NAPRTase
k59_824690_1	1246995.AFR_27395	2.37e-12	70.1	COG0500@1|root,COG2226@2|Bacteria,2GP9N@201174|Actinobacteria,4DFCN@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	Methyltransf_25
k59_106181_1	644282.Deba_1368	6.46e-76	242.0	COG5016@1|root,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,43BUE@68525|delta/epsilon subdivisions,2X75I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyruvate carboxyltransferase	oadA	-	2.1.3.1,4.1.1.3,6.4.1.1	ko:K01571,ko:K01960,ko:K03416	ko00020,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00640,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344,R00353,R00930	RC00040,RC00097,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_269367_1	161528.ED21_17647	5.79e-141	402.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,2KD0W@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_235228_2	756272.Plabr_3887	2.3e-53	181.0	COG1520@1|root,COG1520@2|Bacteria,2IX03@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
k59_138882_1	1266925.JHVX01000006_gene2106	2.49e-78	254.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,37235@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM glycosyl transferase, family 51	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_922600_1	204669.Acid345_0909	3.75e-15	85.1	COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JKYK@204432|Acidobacteriia	204669.Acid345_0909|-	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_563449_1	497964.CfE428DRAFT_2508	3.78e-69	213.0	COG0066@1|root,COG0066@2|Bacteria,46TAY@74201|Verrucomicrobia	74201|Verrucomicrobia	E	3-isopropylmalate dehydratase, small subunit	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_269374_2	70448.A0A090M3E9	1.98e-31	134.0	COG1231@1|root,KOG0029@2759|Eukaryota,37KUS@33090|Viridiplantae,34JQI@3041|Chlorophyta	3041|Chlorophyta	Q	Flavin containing amine oxidoreductase	-	-	-	ko:K11450	ko04714,map04714	-	-	-	ko00000,ko00001,ko01000,ko03036	-	-	-	Amino_oxidase,DEK_C,SWIRM
k59_235240_1	1231185.BAMP01000010_gene2028	9.74e-55	182.0	COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2TTC4@28211|Alphaproteobacteria,43HPC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Phenylacetic acid catabolic protein	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
k59_235240_2	1353531.AZNX01000005_gene3634	3.64e-32	122.0	COG0508@1|root,COG0508@2|Bacteria,1R0J5@1224|Proteobacteria,2U28K@28211|Alphaproteobacteria,4BATY@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_595908_2	305700.B447_17119	6.63e-75	234.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2VP72@28216|Betaproteobacteria,2KW1H@206389|Rhodocyclales	206389|Rhodocyclales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
k59_398514_1	396588.Tgr7_1280	1.42e-26	112.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria	1224|Proteobacteria	L	double-strand break repair protein AddB	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_73794_1	436308.Nmar_0103	1.14e-12	62.8	COG1254@1|root,arCOG01674@2157|Archaea,41SRG@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
k59_73794_2	436308.Nmar_0102	3.22e-90	269.0	COG0090@1|root,arCOG04067@2157|Archaea,41SCT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_786162_2	1123393.KB891331_gene2856	2.19e-17	81.3	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,1KSYK@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_563454_1	864073.HFRIS_017754	1.17e-70	239.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,472JH@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	SurA N-terminal domain	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_432234_1	443144.GM21_3014	1.76e-107	322.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome bd ubiquinol oxidase, subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_987177_1	1236959.BAMT01000002_gene2040	1.91e-50	166.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2VQ0H@28216|Betaproteobacteria,2KMQK@206350|Nitrosomonadales	206350|Nitrosomonadales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_987177_2	1288494.EBAPG3_2690	7.55e-117	341.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2VHPY@28216|Betaproteobacteria,371NK@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_824729_1	1121405.dsmv_0564	2.05e-55	197.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_171472_1	926569.ANT_18520	5.59e-93	279.0	COG0170@1|root,COG0170@2|Bacteria	2|Bacteria	I	dolichyl monophosphate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_73816_1	56780.SYN_01694	1.84e-48	168.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MQ97@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1015789_1	946362.XP_004997743.1	3.98e-28	117.0	COG2132@1|root,2QR4X@2759|Eukaryota,38BK4@33154|Opisthokonta	33154|Opisthokonta	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_726643_1	945713.IALB_3185	1.1e-121	377.0	COG0458@1|root,COG0458@2|Bacteria	2|Bacteria	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_432255_1	1121918.ARWE01000001_gene2378	2.49e-92	275.0	COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,42PZY@68525|delta/epsilon subdivisions,2WJ9V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit	-	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_922637_1	330214.NIDE0003	1.43e-95	301.0	COG0187@1|root,COG0187@2|Bacteria,3J0BB@40117|Nitrospirae	40117|Nitrospirae	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_661503_2	189753.AXAS01000056_gene5959	6.52e-26	103.0	COG2984@1|root,COG2984@2|Bacteria,1RDUT@1224|Proteobacteria,2U8XC@28211|Alphaproteobacteria,3JYZA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_367028_1	1235457.C404_18775	0.000352	42.4	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1K034@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_367028_2	1123354.AUDR01000001_gene2026	5.71e-75	231.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VR5A@28216|Betaproteobacteria,1KRM8@119069|Hydrogenophilales	119069|Hydrogenophilales	V	Ami_2	-	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
k59_955136_1	1122604.JONR01000010_gene3996	7.93e-40	142.0	COG2981@1|root,COG2981@2|Bacteria,1Q181@1224|Proteobacteria	1224|Proteobacteria	E	Etoposide-induced protein 2.4 (EI24)	-	-	-	-	-	-	-	-	-	-	-	-	EI24
k59_73826_1	1125973.JNLC01000010_gene1411	3.77e-57	190.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2TVHP@28211|Alphaproteobacteria,3JQQG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	hydrolases or acyltransferases, alpha beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF1100,Peptidase_S9
k59_73826_2	1304883.KI912532_gene716	1.22e-07	56.6	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,2KVJQ@206389|Rhodocyclales	206389|Rhodocyclales	C	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_563483_1	420662.Mpe_A1137	1.29e-92	307.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,1KJN2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_73833_1	864051.BurJ1DRAFT_2654	8.04e-69	219.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria,1KIYX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_8
k59_498285_2	1485544.JQKP01000018_gene593	3.84e-60	198.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,44VA2@713636|Nitrosomonadales	28216|Betaproteobacteria	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_694207_1	1126627.BAWE01000002_gene1422	9.34e-11	69.7	COG3829@1|root,COG5000@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JTV0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_7
k59_301517_2	945713.IALB_0309	2.54e-75	238.0	COG0750@1|root,COG0750@2|Bacteria	2|Bacteria	M	metalloendopeptidase activity	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_955163_1	1265502.KB905929_gene2242	1.17e-83	259.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,4ABCJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_661528_1	1288494.EBAPG3_23410	6.95e-99	310.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,37235@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM glycosyl transferase, family 51	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_628461_1	1131269.AQVV01000008_gene952	6.3e-12	68.6	COG4198@1|root,COG4198@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_628461_2	96561.Dole_0543	8.36e-13	68.9	COG4123@1|root,COG4123@2|Bacteria,1MXEQ@1224|Proteobacteria,42SAA@68525|delta/epsilon subdivisions,2WPCM@28221|Deltaproteobacteria,2MJTD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Methyltransferase small domain	-	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
k59_757501_1	1419583.V466_18455	3.23e-27	111.0	2E2YT@1|root,32XZH@2|Bacteria,1MYTS@1224|Proteobacteria,1RURE@1236|Gammaproteobacteria,1YRYJ@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_367057_1	13249.RPRC004498-PA	1.2e-39	144.0	2CNBX@1|root,2QV3V@2759|Eukaryota,39W09@33154|Opisthokonta,3BH5J@33208|Metazoa,3E62V@33213|Bilateria,42B7K@6656|Arthropoda,3T0MX@50557|Insecta,3EEBZ@33342|Paraneoptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_889043_1	671143.DAMO_0568	9.82e-55	191.0	COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria	2|Bacteria	J	elongation factor G	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_235301_1	1049564.TevJSym_ae00570	4.93e-05	47.0	COG4191@1|root,COG4191@2|Bacteria,1QVHZ@1224|Proteobacteria,1S2DC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_235301_2	1408419.JHYG01000015_gene2550	1.49e-62	211.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VF7J@28211|Alphaproteobacteria,2JRGK@204441|Rhodospirillales	204441|Rhodospirillales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4384,Pkinase
k59_528136_1	945713.IALB_1797	3.32e-20	89.4	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria	2|Bacteria	C	malic enzyme	maeB	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.38,1.1.1.40,2.3.1.8	ko:K00027,ko:K00029,ko:K00625,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020	M00169,M00172,M00357,M00579	R00214,R00216,R00230,R00921	RC00004,RC00105,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
k59_528136_2	1121104.AQXH01000004_gene92	1.38e-43	157.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IT7X@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HTH_18,TPR_2,TPR_8
k59_398580_2	1454004.AW11_01636	4.76e-74	235.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,1KQBU@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_73869_1	1169143.KB911035_gene2452	2.02e-06	51.2	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,1K4J9@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_889054_1	1229780.BN381_130221	4.58e-58	194.0	COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_661558_2	472759.Nhal_1370	1.37e-49	164.0	COG1018@1|root,COG1018@2|Bacteria,1R5YD@1224|Proteobacteria,1T2RI@1236|Gammaproteobacteria,1WY0W@135613|Chromatiales	135613|Chromatiales	C	PFAM Oxidoreductase FAD NAD(P)-binding	-	-	1.6.2.2	ko:K00326	ko00520,map00520	-	R00100	-	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_889062_1	420662.Mpe_A3035	1.14e-180	512.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,1KJ2B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 2 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_301550_1	99598.Cal7507_1664	3.41e-19	93.6	COG0612@1|root,COG0612@2|Bacteria,1G303@1117|Cyanobacteria,1HJ8Q@1161|Nostocales	1117|Cyanobacteria	S	PFAM Peptidase M16 inactive domain	ymxG	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_301555_1	1121428.DESHY_160239___1	1.38e-19	86.3	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,260MZ@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter	livF1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_301555_2	907348.TresaDRAFT_2688	3.52e-35	129.0	COG0411@1|root,COG0411@2|Bacteria,2J67T@203691|Spirochaetes	203691|Spirochaetes	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_563545_1	296591.Bpro_4389	3.3e-18	84.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VH3X@28216|Betaproteobacteria,4ACJ7@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_563545_2	1449353.JQMQ01000004_gene5932	1.08e-31	120.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,2NHIR@228398|Streptacidiphilus	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_596016_1	314230.DSM3645_19383	2.27e-37	131.0	COG1846@1|root,COG1846@2|Bacteria,2J3AR@203682|Planctomycetes	203682|Planctomycetes	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR
k59_269494_1	396588.Tgr7_2034	5.4e-76	248.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RYC8@1236|Gammaproteobacteria,1WX4W@135613|Chromatiales	135613|Chromatiales	G	Transketolase central region	-	-	-	-	-	-	-	-	-	-	-	-	XFP,XFP_N
k59_628520_1	391615.ABSJ01000037_gene958	3.68e-16	83.2	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1J8DT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4131)	ycaI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_270567_2	1191523.MROS_1774	2.39e-24	102.0	COG0243@1|root,COG0243@2|Bacteria	2|Bacteria	C	molybdopterin cofactor binding	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_662681_1	279714.FuraDRAFT_0471	3.47e-206	602.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KPNP@206351|Neisseriales	206351|Neisseriales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_140108_1	1265505.ATUG01000001_gene4710	9.81e-85	261.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria,2MKR7@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_368224_1	161528.ED21_23756	1.57e-11	70.1	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2U31V@28211|Alphaproteobacteria,2K3PY@204457|Sphingomonadales	204457|Sphingomonadales	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_140111_1	945713.IALB_0877	9.5e-10	64.3	COG3328@1|root,COG3328@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_695436_1	1229909.NSED_00015	4.39e-80	244.0	COG0648@1|root,arCOG01894@2157|Archaea,41SDW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
k59_727887_1	1163409.UUA_10741	5.61e-18	83.6	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1X5C6@135614|Xanthomonadales	135614|Xanthomonadales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_433396_1	1120792.JAFV01000001_gene2179	3.34e-51	177.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,36ZM3@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_00510	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_499492_2	247634.GPB2148_137	7.17e-61	195.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,1RS4N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_665007_2	543728.Vapar_0459	2.86e-89	285.0	COG4122@1|root,COG4122@2|Bacteria,1QWCT@1224|Proteobacteria,2VJBK@28216|Betaproteobacteria,4ACMD@80864|Comamonadaceae	28216|Betaproteobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_304689_1	1120980.JQKH01000038_gene1980	8.36e-31	125.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,2KPTM@206351|Neisseriales	206351|Neisseriales	J	glycyl-tRNA synthetase beta	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_304689_2	887898.HMPREF0551_0153	5.19e-48	163.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2VIQX@28216|Betaproteobacteria,1K1XK@119060|Burkholderiaceae	28216|Betaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
k59_631808_1	296591.Bpro_4323	6.7e-47	163.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VNKP@28216|Betaproteobacteria,4ABUE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_304691_1	1005048.CFU_2340	1.39e-33	126.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,473AW@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_1017714_2	402881.Plav_0467	1.02e-05	51.2	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2U8WW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_466609_1	768671.ThimaDRAFT_0814	3.14e-116	345.0	COG0348@1|root,COG0348@2|Bacteria,1MUWD@1224|Proteobacteria,1RZ0Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
k59_990617_1	1144313.PMI10_01372	4.89e-10	61.2	COG0283@1|root,COG0283@2|Bacteria,4NEMB@976|Bacteroidetes,1HXBA@117743|Flavobacteriia,2NS6J@237|Flavobacterium	976|Bacteroidetes	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
k59_501836_1	525897.Dbac_0403	6.14e-136	400.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2M8ZN@213115|Desulfovibrionales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_338074_1	1131553.JIBI01000002_gene1819	2.31e-136	393.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,3724X@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_338074_2	557598.LHK_00180	2.31e-23	95.1	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2VR3M@28216|Betaproteobacteria,2KQCS@206351|Neisseriales	206351|Neisseriales	S	SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_1017723_1	1163617.SCD_n01957	1.89e-120	362.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_828364_1	592029.DDD_0510	5.58e-11	63.2	COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,1HWVX@117743|Flavobacteriia,3HJHA@363408|Nonlabens	976|Bacteroidetes	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_304727_1	1123399.AQVE01000010_gene3247	2.2e-99	298.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,460FM@72273|Thiotrichales	72273|Thiotrichales	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_990645_1	331869.BAL199_13840	7.19e-06	50.4	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,LZ_Tnp_IS481,rve
k59_370412_2	395493.BegalDRAFT_1908	9.07e-46	157.0	COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,1RMZN@1236|Gammaproteobacteria,462HG@72273|Thiotrichales	72273|Thiotrichales	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA
k59_958766_1	1131814.JAFO01000001_gene1997	9.87e-99	304.0	COG0747@1|root,COG0747@2|Bacteria,1MWR7@1224|Proteobacteria,2TS51@28211|Alphaproteobacteria,3EZHC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	MA20_22710	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5,TAT_signal
k59_272293_1	330214.NIDE3959	1.19e-69	222.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	1.1.1.42,1.3.1.85	ko:K00031,ko:K14446	ko00020,ko00480,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00373,M00740	R00267,R00268,R01899,R09291	RC00001,RC00084,RC00114,RC00626,RC02481,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,GGDEF,PAS_9
k59_272293_2	330214.NIDE3958	4.55e-108	332.0	COG3220@1|root,COG3220@2|Bacteria,3J130@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF692)	-	-	-	-	-	-	-	-	-	-	-	-	DUF692
k59_207439_1	596154.Alide2_1981	2.39e-99	311.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,4A9N2@80864|Comamonadaceae	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_567040_2	330214.NIDE3058	5.67e-43	155.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
k59_272294_1	1123229.AUBC01000008_gene528	1.17e-25	104.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria,3JUIW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	VWA domain containing CoxE-like protein	coxE	-	-	-	-	-	-	-	-	-	-	-	VWA_CoxE
k59_272294_2	1123228.AUIH01000004_gene1087	7.28e-44	152.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,1MWFN@1224|Proteobacteria,1RV4F@1236|Gammaproteobacteria,1XQ7H@135619|Oceanospirillales	135619|Oceanospirillales	O	XdhC Rossmann domain	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_C,XdhC_CoxI
k59_697887_1	330214.NIDE3268	5.64e-88	270.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_787386_1	381666.H16_A2060	1.09e-65	220.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,1K0GW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_370436_1	1117318.PRUB_21048	5.07e-28	112.0	COG0748@1|root,COG0748@2|Bacteria,1RFVC@1224|Proteobacteria,1S3AV@1236|Gammaproteobacteria,2Q2XT@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Putative_PNPOx,Pyrid_oxidase_2
k59_401503_1	1031711.RSPO_c01374	9.66e-91	270.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,1K15D@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_401504_1	1209072.ALBT01000038_gene2365	3.81e-18	88.6	COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,1S157@1236|Gammaproteobacteria,1FFU3@10|Cellvibrio	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_109820_1	1458275.AZ34_08620	2.08e-163	467.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,4AAKI@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_44427_1	1297570.MESS4_830443	2.18e-25	106.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,43HUM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_44427_2	395494.Galf_2676	1.71e-26	107.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,44VGZ@713636|Nitrosomonadales	28216|Betaproteobacteria	J	PFAM RNA-binding protein AU-1 Ribonuclease E G	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_567063_1	945713.IALB_0787	5.3e-18	77.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.11.1,4.6.1.1	ko:K01768,ko:K12132	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	DUF3467
k59_567063_2	1191523.MROS_0259	2.33e-18	87.4	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	2.7.8.12	ko:K09809,ko:K20543	-	-	-	-	ko00000,ko01000,ko02000	1.B.55.3	-	-	BCSC_C,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
k59_1017760_1	187272.Mlg_1958	2.9e-17	84.7	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_401508_1	419947.MRA_0767	5.41e-06	48.9	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,232EQ@1762|Mycobacteriaceae	201174|Actinobacteria	KT	response regulator	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_401508_2	290397.Adeh_0733	6.1e-35	130.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WP2A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_304791_1	396588.Tgr7_0774	5.61e-109	324.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_401510_1	644282.Deba_0086	4.78e-87	277.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2WINP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782,ko:K07516	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04743,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_990711_1	478741.JAFS01000001_gene1273	6.93e-77	246.0	COG4992@1|root,COG4992@2|Bacteria,46UBT@74201|Verrucomicrobia,37FZC@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-III	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_370464_1	1386089.N865_03230	2.96e-54	192.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4FETX@85021|Intrasporangiaceae	201174|Actinobacteria	C	Xanthine dehydrogenase	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_860196_1	1229909.NSED_09185	5.41e-08	54.3	COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI
k59_860196_2	1229909.NSED_09190	1.79e-54	171.0	COG2450@1|root,arCOG02263@2157|Archaea,41T6T@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
k59_697928_1	94624.Bpet0547	6.8e-52	173.0	COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2VMYA@28216|Betaproteobacteria,3T1MC@506|Alcaligenaceae	28216|Betaproteobacteria	E	branched-chain amino acid	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_697928_2	397945.Aave_3170	3.26e-49	164.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2VMC0@28216|Betaproteobacteria,4ABMQ@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_142527_2	261292.Nit79A3_1690	5.85e-49	171.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,3726P@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
k59_77512_1	113395.AXAI01000002_gene5237	1.1e-71	225.0	COG2141@1|root,COG2141@2|Bacteria,1R76K@1224|Proteobacteria,2VF18@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_370470_1	1459636.NTE_03208	2.99e-135	404.0	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_207504_1	439235.Dalk_4421	2.38e-12	68.6	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MI2B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
k59_207504_2	673860.AciM339_1390	3.35e-15	75.5	COG0784@1|root,arCOG02391@2157|Archaea,2Y72G@28890|Euryarchaeota,3F39M@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Response regulator receiver domain	-	-	-	ko:K07662	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
k59_567106_1	330214.NIDE2515	1.31e-49	181.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2,DUF3971,DUF748
k59_860217_1	1288494.EBAPG3_7340	5.9e-37	140.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,3720P@32003|Nitrosomonadales	28216|Betaproteobacteria	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_530095_1	1217718.ALOU01000040_gene185	1.08e-68	229.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria	28216|Betaproteobacteria	M	surface antigen variable number repeat protein	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_44475_1	945713.IALB_2900	2.36e-74	225.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
k59_371709_2	370438.PTH_2793	2.19e-11	63.2	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_829822_1	467661.RKLH11_3567	2.51e-23	92.4	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_239349_1	1232683.ADIMK_3666	7.1e-46	162.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,46547@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016740,GO:0017013,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0031975,GO:0036094,GO:0036211,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:0098552,GO:0098567,GO:1901265,GO:1901363,GO:1901564	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_78861_1	243159.AFE_2550	1.85e-29	117.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,2NC2W@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_861475_2	1121448.DGI_2491	5.97e-11	64.7	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42QZT@68525|delta/epsilon subdivisions,2WK41@28221|Deltaproteobacteria,2M9V3@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_991990_1	1194972.MVAC_16791	2.44e-51	176.0	COG2015@1|root,COG2015@2|Bacteria,2H3T3@201174|Actinobacteria,235UZ@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
k59_991992_1	1121875.KB907546_gene2198	4.77e-39	148.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_893693_1	864051.BurJ1DRAFT_0165	1.23e-57	187.0	COG2863@1|root,COG2863@2|Bacteria,1RM00@1224|Proteobacteria,2VTQZ@28216|Betaproteobacteria,1KNMQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_666537_2	395494.Galf_0253	3.11e-42	145.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,44VR2@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
k59_829842_1	330214.NIDE0473	2.25e-136	395.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
k59_600887_1	1123501.KB902295_gene3553	7.39e-08	60.5	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_633245_1	381666.H16_B1390	3.19e-133	387.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1K0KJ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp2	-	3.1.3.11,3.1.3.37	ko:K01086,ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
k59_574129_1	323848.Nmul_A0176	6.73e-100	313.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,372D7@32003|Nitrosomonadales	28216|Betaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_407345_1	1235457.C404_19500	1.75e-83	256.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2VK16@28216|Betaproteobacteria,1K64U@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
k59_606340_1	472759.Nhal_1814	2.36e-158	460.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,1X2NN@135613|Chromatiales	135613|Chromatiales	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_149458_1	1033743.CAES01000046_gene273	3.54e-52	175.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26R5U@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K17214	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_214234_1	580332.Slit_0703	1.34e-07	52.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VH18@28216|Betaproteobacteria,44VG4@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	alcE	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
k59_214234_2	1408419.JHYG01000008_gene2329	1.89e-31	120.0	COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria,2UBM6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	DSBA-like thioredoxin domain	-	-	-	ko:K07396	-	-	-	-	ko00000	-	-	-	DSBA,Thioredoxin_5
k59_19104_1	1121861.KB899917_gene3708	3.53e-68	215.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	MA20_30645	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_965968_2	1125863.JAFN01000001_gene2342	2.73e-09	56.2	COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,42T0G@68525|delta/epsilon subdivisions,2WPJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_345043_1	330214.NIDE3303	3.11e-56	193.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
k59_533362_1	1163617.SCD_n00398	9.72e-111	329.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_965976_1	1353528.DT23_18185	9.88e-44	161.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2XM4U@285107|Thioclava	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_898852_1	1266925.JHVX01000004_gene1149	3.94e-118	352.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,372QJ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	THUMP	rlmL	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
k59_867080_2	876269.ARWA01000001_gene3722	6.26e-14	68.6	COG1366@1|root,COG1366@2|Bacteria,1NECY@1224|Proteobacteria,2UHIF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
k59_407359_1	645991.Sgly_3092	1.64e-18	90.9	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2490A@186801|Clostridia,26087@186807|Peptococcaceae	186801|Clostridia	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_311153_1	357808.RoseRS_1213	2.22e-84	277.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,2G5M1@200795|Chloroflexi,376VN@32061|Chloroflexia	32061|Chloroflexia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_214253_1	580332.Slit_1685	6.16e-110	325.0	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,2VPBV@28216|Betaproteobacteria,44WDK@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_214254_1	1216976.AX27061_5575	2.7e-33	125.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,3T1ZX@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_606372_1	926550.CLDAP_10590	2.74e-24	97.1	COG1845@1|root,COG1845@2|Bacteria,2G74U@200795|Chloroflexi	200795|Chloroflexi	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
k59_606372_2	1128421.JAGA01000003_gene3641	6.14e-12	65.1	COG1999@1|root,COG1999@2|Bacteria,2NRAY@2323|unclassified Bacteria	2|Bacteria	S	SCO1/SenC	hyaE	GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277	-	ko:K03619,ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	HyaE,SCO1-SenC
k59_181963_1	592316.Pat9b_3603	3.97e-17	80.5	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,3VXID@53335|Pantoea	1236|Gammaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726	Shikimate_DH,Shikimate_dh_N
k59_181963_2	998674.ATTE01000001_gene2159	7.2e-66	209.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,45ZPX@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_835661_1	1144310.PMI07_005439	3.7e-31	119.0	COG0600@1|root,COG0600@2|Bacteria,1PF1W@1224|Proteobacteria,2UQ2K@28211|Alphaproteobacteria,4BJDU@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_442403_1	1182590.BN5_03879	5.37e-96	298.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1YIUZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Elongation factor G C-terminus	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_442407_1	1121035.AUCH01000003_gene1368	2.06e-10	62.4	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,2KUUI@206389|Rhodocyclales	206389|Rhodocyclales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
k59_345081_2	1266925.JHVX01000013_gene1642	3.68e-24	99.8	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria,371NY@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Peptidase family M23	envC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_966010_1	1266925.JHVX01000007_gene2349	2.07e-225	632.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,372CW@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_508900_1	316057.RPD_1530	1.58e-34	125.0	COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2U6JY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_737572_1	909613.UO65_5156	1.68e-48	167.0	COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria,4E5PV@85010|Pseudonocardiales	201174|Actinobacteria	GM	Male sterility protein	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_997549_2	1121013.P873_12535	9.67e-72	230.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,1X32P@135614|Xanthomonadales	135614|Xanthomonadales	E	aminotransferase	-	-	2.6.1.2,2.6.1.66	ko:K14260	ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230	-	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_377152_1	545276.KB898730_gene1472	2.23e-14	77.0	2E61B@1|root,330QK@2|Bacteria,1N39M@1224|Proteobacteria,1SMYA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_835678_1	640081.Dsui_0442	1.17e-69	216.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,2KUYM@206389|Rhodocyclales	206389|Rhodocyclales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_966022_1	1278307.KB906967_gene2541	2.57e-05	48.9	2EZ64@1|root,33SC6@2|Bacteria,1NU9P@1224|Proteobacteria	1224|Proteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
k59_867128_1	311402.Avi_0693	1.84e-27	117.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,4B7NK@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_737599_1	489825.LYNGBM3L_24160	9.02e-20	94.4	COG3409@1|root,COG3409@2|Bacteria,1G21V@1117|Cyanobacteria,1HA1I@1150|Oscillatoriales	1117|Cyanobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_19177_1	1502724.FF80_01555	9.59e-71	226.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2TU5K@28211|Alphaproteobacteria,3N6TM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
k59_407403_1	589873.EP13_14390	1.37e-67	217.0	COG0477@1|root,COG2814@2|Bacteria,1MVKJ@1224|Proteobacteria,1RMHJ@1236|Gammaproteobacteria,466AE@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	Sugar (and other) transporter	-	-	-	ko:K05548	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,Sugar_tr
k59_182010_1	1121035.AUCH01000006_gene709	1.03e-86	264.0	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,2VJB9@28216|Betaproteobacteria,2KURI@206389|Rhodocyclales	206389|Rhodocyclales	P	membrane protein, TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_898912_1	1123504.JQKD01000003_gene566	1.05e-77	259.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_311215_1	998674.ATTE01000001_gene3212	2.13e-83	258.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,4622K@72273|Thiotrichales	72273|Thiotrichales	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_638789_1	582515.KR51_00034260	1.43e-55	181.0	COG3335@1|root,COG3335@2|Bacteria,1G6DJ@1117|Cyanobacteria	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_28,HTH_29
k59_574220_1	1499967.BAYZ01000029_gene1223	2.9e-43	158.0	COG1530@1|root,COG1530@2|Bacteria,2NNQR@2323|unclassified Bacteria	2|Bacteria	J	Ribonuclease E/G family	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_898922_1	945713.IALB_0659	8.6e-29	104.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	nfuA	-	-	-	-	-	-	-	-	-	-	-	NifU
k59_898922_2	1191523.MROS_2847	4e-07	54.7	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	yueF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_51300_1	1232410.KI421422_gene2043	4.2e-25	101.0	COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,43SMN@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_574224_1	261292.Nit79A3_0379	4.57e-24	95.5	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2VJ98@28216|Betaproteobacteria,3724S@32003|Nitrosomonadales	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_574224_2	580332.Slit_0512	2.97e-86	258.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2VQ3U@28216|Betaproteobacteria,44VRQ@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_378021_2	395495.Lcho_2116	1.91e-31	124.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,1KJWT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	carboxylase	accA1	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_215205_1	279714.FuraDRAFT_0214	1.16e-11	62.8	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VJMC@28216|Betaproteobacteria,2KPNQ@206351|Neisseriales	206351|Neisseriales	S	Belongs to the WrbA family	wrbA	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
k59_215205_2	477184.KYC_18100	9.67e-86	273.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,3T2KE@506|Alcaligenaceae	28216|Betaproteobacteria	S	UPF0761 membrane protein	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_934396_1	1229909.NSED_03465	1.09e-66	213.0	COG0517@1|root,arCOG00600@2157|Archaea	2157|Archaea	K	CBS domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
k59_408179_1	391165.GbCGDNIH1_1506	1.77e-09	57.8	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,2JQ45@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_408179_2	648757.Rvan_0814	1.14e-120	353.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria,3N684@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_673330_1	96561.Dole_0965	1.99e-20	82.8	COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria,2MM0N@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_966996_1	420662.Mpe_A1893	9.03e-68	217.0	COG2304@1|root,COG2304@2|Bacteria,1PRHK@1224|Proteobacteria,2VS8H@28216|Betaproteobacteria,1KNHA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K16257	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001	-	-	-	VWA_2
k59_378029_2	330214.NIDE0440	4.65e-115	342.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_150485_2	639283.Snov_0227	1.16e-56	189.0	COG0596@1|root,COG0596@2|Bacteria,1QTTN@1224|Proteobacteria,2TRYE@28211|Alphaproteobacteria,3F0NJ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,CMD
k59_607362_1	649638.Trad_0121	1.11e-86	269.0	COG0160@1|root,COG0160@2|Bacteria,1WJ8V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_868073_1	1348663.KCH_26220	4.1e-53	185.0	COG5323@1|root,COG5362@1|root,COG5410@1|root,COG5323@2|Bacteria,COG5362@2|Bacteria,COG5410@2|Bacteria,2I1XF@201174|Actinobacteria,2M5NQ@2063|Kitasatospora	201174|Actinobacteria	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6
k59_607364_1	1232410.KI421426_gene1372	1.77e-115	355.0	COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,42Q4Z@68525|delta/epsilon subdivisions,2WM28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase
k59_20131_1	580332.Slit_2552	5.49e-149	437.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,2W0G7@28216|Betaproteobacteria	28216|Betaproteobacteria	C	ATPsynthase alpha/beta subunit N-term extension	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_150489_1	1279019.ARQK01000016_gene1267	1.46e-78	253.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1WZX0@135613|Chromatiales	135613|Chromatiales	Q	PFAM multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_150489_2	426114.THI_0694	8.03e-39	142.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2WGJC@28216|Betaproteobacteria,1KPCI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_443349_1	1163617.SCD_n01800	3.68e-75	236.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria	28216|Betaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_607370_1	999141.GME_17587	2.91e-35	139.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1XNQM@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_52159_1	997346.HMPREF9374_2165	9.52e-18	87.4	COG1482@1|root,COG1940@1|root,COG1482@2|Bacteria,COG1940@2|Bacteria,1UWKC@1239|Firmicutes,4I34X@91061|Bacilli,27CQT@186824|Thermoactinomycetaceae	91061|Bacilli	G	Phosphomannose isomerase type I	-	-	-	-	-	-	-	-	-	-	-	-	PMI_typeI
k59_934426_1	330214.NIDE3058	2.24e-71	230.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
k59_706189_1	557598.LHK_01852	1.24e-35	134.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,2KQR1@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_443356_1	1120966.AUBU01000006_gene3218	1.25e-73	236.0	28KGC@1|root,2ZA25@2|Bacteria,4NH1T@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_673370_1	62928.azo2895	4.16e-101	305.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,2KUEI@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_346048_1	85643.Tmz1t_1298	7.02e-58	188.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2VJ19@28216|Betaproteobacteria,2KV78@206389|Rhodocyclales	206389|Rhodocyclales	G	to the hyi family	hfi	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
k59_473311_1	1157708.KB907452_gene3524	5.6e-78	242.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,4AAJE@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_312065_1	1163409.UUA_15198	6.75e-79	237.0	COG3293@1|root,COG3293@2|Bacteria,1PHNY@1224|Proteobacteria,1TDHI@1236|Gammaproteobacteria,1XARD@135614|Xanthomonadales	135614|Xanthomonadales	L	COG3293 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_772550_1	436308.Nmar_0011	4.8e-113	344.0	COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_679330_1	1229909.NSED_01125	1.87e-103	320.0	COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
k59_905317_1	1408444.JHYC01000003_gene664	2.14e-28	113.0	COG3039@1|root,COG3039@2|Bacteria,1Q9AW@1224|Proteobacteria,1RNU1@1236|Gammaproteobacteria,1JEXN@118969|Legionellales	118969|Legionellales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_279256_1	488538.SAR116_1471	1.21e-75	236.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_188251_1	1121033.AUCF01000001_gene1935	1.07e-53	187.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,2JSHH@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
k59_613086_1	330214.NIDE0867	6e-102	305.0	COG4775@1|root,COG4775@2|Bacteria,3J10P@40117|Nitrospirae	40117|Nitrospirae	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
k59_972997_1	3847.GLYMA13G11830.1	1.15e-17	75.9	2DZEY@1|root,2S7E1@2759|Eukaryota,3805F@33090|Viridiplantae,3GPYC@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1024482_1	945713.IALB_1719	2.63e-57	198.0	COG1404@1|root,COG4409@1|root,COG1404@2|Bacteria,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,CelD_N,FlgD_ig,Glyco_hydro_9,VCBS
k59_515809_1	582744.Msip34_0727	1.12e-85	275.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	type II secretion system protein E	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_712128_1	998088.B565_0017	1.46e-43	157.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1Y58E@135624|Aeromonadales	135624|Aeromonadales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_279261_1	1203611.KB894547_gene2595	2.83e-88	296.0	COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,4NG54@976|Bacteroidetes,2FN2V@200643|Bacteroidia,22V21@171550|Rikenellaceae	976|Bacteroidetes	D	Phage-related minor tail protein	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_581187_1	713586.KB900536_gene1975	1.44e-79	240.0	COG0288@1|root,COG0288@2|Bacteria,1R3SC@1224|Proteobacteria,1RRB4@1236|Gammaproteobacteria,1WXB8@135613|Chromatiales	135613|Chromatiales	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_351782_1	1232437.KL661978_gene3781	2.05e-42	162.0	COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,42P27@68525|delta/epsilon subdivisions,2WK9Y@28221|Deltaproteobacteria,2MJZE@213118|Desulfobacterales	28221|Deltaproteobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,TPR_16,TPR_8,TonB_dep_Rec,zinc_ribbon_4
k59_156272_1	945713.IALB_1608	4.53e-93	283.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_220795_1	391735.Veis_3991	2.73e-46	165.0	COG3181@1|root,COG3181@2|Bacteria,1R4DA@1224|Proteobacteria,2VPWK@28216|Betaproteobacteria,4AH15@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_317238_1	1122604.JONR01000003_gene1450	8.33e-51	169.0	28HCW@1|root,2ZB7F@2|Bacteria,1R8H4@1224|Proteobacteria,1RP13@1236|Gammaproteobacteria,1X6X4@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_940339_1	580332.Slit_0431	2.01e-31	112.0	COG5341@1|root,COG5341@2|Bacteria,1N1PN@1224|Proteobacteria,2VUW8@28216|Betaproteobacteria,44VY7@713636|Nitrosomonadales	28216|Betaproteobacteria	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
k59_940339_2	395494.Galf_0286	2.52e-50	165.0	COG4769@1|root,COG4769@2|Bacteria,1RJIB@1224|Proteobacteria,2VRM1@28216|Betaproteobacteria,44VVI@713636|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
k59_156276_1	84531.JMTZ01000078_gene2201	7.78e-24	97.4	COG2944@1|root,COG2944@2|Bacteria,1N21E@1224|Proteobacteria,1SS0W@1236|Gammaproteobacteria,1X8P3@135614|Xanthomonadales	135614|Xanthomonadales	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
k59_842759_1	305700.B447_12639	4.35e-75	249.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales	206389|Rhodocyclales	CM	Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_712143_1	365044.Pnap_3600	1.8e-17	83.2	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,4AAVM@80864|Comamonadaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator, winged helix family	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_744577_1	330214.NIDE0484	1.08e-99	297.0	COG0078@1|root,COG0078@2|Bacteria,3J0G7@40117|Nitrospirae	40117|Nitrospirae	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_91510_1	857087.Metme_1661	8.1e-140	429.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RQ6V@1236|Gammaproteobacteria,1XDWC@135618|Methylococcales	135618|Methylococcales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_973033_1	983917.RGE_16710	8.91e-43	147.0	COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,2VQ64@28216|Betaproteobacteria,1KK7D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
k59_973033_2	1169152.AXVD01000011_gene4109	0.000509	42.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4FX1I@85025|Nocardiaceae	201174|Actinobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_905362_1	330214.NIDE3916	3.99e-138	424.0	COG0841@1|root,COG0841@2|Bacteria,3J0VZ@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_383414_2	977880.RALTA_A1969	4.48e-49	171.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,1K20K@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_645490_2	55601.VANGNB10_cI0057	5.08e-07	53.1	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1XUKE@135623|Vibrionales	135623|Vibrionales	C	protein containing LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_792842_2	1458357.BG58_17180	3.79e-31	115.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2VRQ3@28216|Betaproteobacteria,1K7KD@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
k59_220825_1	1034807.FBFL15_2909	3.02e-19	92.0	COG3344@1|root,COG3344@2|Bacteria,4NGJQ@976|Bacteroidetes,1I0E3@117743|Flavobacteriia,2NVSQ@237|Flavobacterium	976|Bacteroidetes	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_478329_1	375286.mma_2838	4.48e-36	131.0	COG0516@1|root,COG0516@2|Bacteria,1MUJM@1224|Proteobacteria,2VJMM@28216|Betaproteobacteria,473ZI@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides	guaC	-	1.7.1.7	ko:K00364	ko00230,map00230	-	R01134	RC00457	ko00000,ko00001,ko01000	-	-	-	IMPDH
k59_478329_2	999423.HMPREF9161_01041	5.17e-08	58.5	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,4H2B2@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_25950_1	945713.IALB_0014	3.67e-29	110.0	COG0357@1|root,COG0357@2|Bacteria	2|Bacteria	J	rRNA methyltransferase activity	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_793226_2	1121035.AUCH01000015_gene2577	8.47e-46	152.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,2KW5B@206389|Rhodocyclales	206389|Rhodocyclales	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_189349_1	330214.NIDE4088	2.16e-35	127.0	COG0319@1|root,COG0319@2|Bacteria,3J0US@40117|Nitrospirae	40117|Nitrospirae	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
k59_1025083_1	748247.AZKH_0447	1.44e-120	372.0	COG0074@1|root,COG0074@2|Bacteria,1R4KP@1224|Proteobacteria,2W14T@28216|Betaproteobacteria,2KYIY@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Succ_CoA_lig
k59_745698_1	945713.IALB_2868	1.83e-107	323.0	COG2986@1|root,COG2986@2|Bacteria	2|Bacteria	E	ammonia-lyase activity	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_27008_1	1267535.KB906767_gene392	1.19e-27	112.0	COG3643@1|root,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria,2JIP9@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Formiminotransferase domain	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_N
k59_974196_1	521674.Plim_3990	6.72e-98	301.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_384450_1	1458275.AZ34_08905	6.38e-16	76.6	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,4AIFH@80864|Comamonadaceae	28216|Betaproteobacteria	P	Divalent cation transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_384450_2	420662.Mpe_A1423	1.87e-14	70.1	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VQEB@28216|Betaproteobacteria,1KKNW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_582359_2	314275.MADE_1015775	1.29e-39	145.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1RMDN@1236|Gammaproteobacteria,46BUP@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	N-acetylmuramoyl-L-alanine amidase	amiD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.4.16.4,3.5.1.28	ko:K01447,ko:K11066,ko:K21469	ko00550,map00550	-	R04112	RC00064,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Amidase_2,PG_binding_1
k59_906438_1	330214.NIDE0734	3.11e-14	71.2	COG0075@1|root,COG0075@2|Bacteria,3J0FC@40117|Nitrospirae	2|Bacteria	E	Evidence 2b Function of strongly homologous gene	phnW	GO:0003674,GO:0003824	2.5.1.49,2.6.1.37,3.11.1.1	ko:K01740,ko:K03430,ko:K05306,ko:K09469	ko00270,ko00440,ko01100,ko01120,map00270,map00440,map01100,map01120	-	R00747,R01287,R04152,R04859	RC00008,RC00020,RC00062,RC00368,RC02821,RC02848	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_5
k59_906438_2	330214.NIDE0733	2.41e-73	223.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
k59_773492_2	1229909.NSED_09500	4.91e-126	378.0	COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_680532_1	265072.Mfla_2519	3.83e-17	80.1	COG4726@1|root,COG4726@2|Bacteria,1N9CE@1224|Proteobacteria,2VWPP@28216|Betaproteobacteria,2KNA2@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_124654_1	1123269.NX02_15280	4.16e-05	48.1	COG0451@1|root,COG0451@2|Bacteria,1MWYB@1224|Proteobacteria,2TSDE@28211|Alphaproteobacteria,2K164@204457|Sphingomonadales	204457|Sphingomonadales	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_124654_2	1163409.UUA_11723	3.59e-20	90.1	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1X3S9@135614|Xanthomonadales	135614|Xanthomonadales	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_221877_1	224911.27352379	1.39e-30	115.0	COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,2U076@28211|Alphaproteobacteria,3JUQH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_189393_1	765910.MARPU_12150	1.39e-13	72.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_189393_2	2903.EOD18169	1.07e-23	100.0	COG0154@1|root,KOG4780@1|root,KOG1211@2759|Eukaryota,KOG4780@2759|Eukaryota	2759|Eukaryota	J	RNA polymerase II CTD heptapeptide repeat phosphatase activity	RPAP2	GO:0000428,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008420,GO:0009058,GO:0009059,GO:0009301,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016073,GO:0016311,GO:0016591,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019899,GO:0030154,GO:0030880,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032502,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0036211,GO:0042578,GO:0042795,GO:0043170,GO:0043175,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055029,GO:0060255,GO:0061695,GO:0065007,GO:0070013,GO:0070063,GO:0070940,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0098781,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1902494,GO:1903506,GO:1990234,GO:2000112,GO:2001141	3.1.3.16,3.5.1.4	ko:K01426,ko:K03457,ko:K20827	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko01009,ko03021	2.A.39	-	-	Amidase,RPAP2_Rtr1
k59_537356_1	1239962.C943_03316	3.97e-55	197.0	COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,4NG54@976|Bacteroidetes,47MT2@768503|Cytophagia	976|Bacteroidetes	D	tail tape measure protein, TP901 family	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_582380_1	1123376.AUIU01000012_gene1617	1.6e-109	348.0	COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_874857_1	1415780.JPOG01000001_gene1249	6.85e-51	175.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1X3A1@135614|Xanthomonadales	135614|Xanthomonadales	C	E3 component of 2-oxoglutarate dehydrogenase complex	ldp	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_874857_2	765912.Thimo_0681	7.23e-34	126.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1WXGA@135613|Chromatiales	135613|Chromatiales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_941527_1	1288494.EBAPG3_9300	6.13e-107	320.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,2VNGX@28216|Betaproteobacteria,3728S@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_941527_2	1163617.SCD_n02641	0.000134	43.9	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_582386_2	701521.PECL_376	1.49e-24	104.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,3F3W8@33958|Lactobacillaceae	91061|Bacilli	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
k59_279901_1	626887.J057_05566	4.9e-07	52.0	COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,1RXZH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_279901_2	1201290.M902_2442	4.16e-13	69.7	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2MT4J@213481|Bdellovibrionales,2WMS0@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_537359_1	1123367.C666_05545	2.78e-70	233.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_384478_1	706587.Desti_0412	1.23e-45	160.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MFG@68525|delta/epsilon subdivisions,2WJKK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1025107_1	760117.JN27_10200	3.02e-96	301.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,472AJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_941537_1	1116472.MGMO_162c00080	1.15e-148	440.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XDPG@135618|Methylococcales	135618|Methylococcales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_58721_1	945713.IALB_1733	1.11e-46	160.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	fni	GO:0003674,GO:0003824,GO:0004452,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:1901576	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
k59_480021_1	1532557.JL37_04945	8.96e-122	390.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_385485_1	448385.sce7610	2.85e-53	187.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2YZAF@29|Myxococcales	28221|Deltaproteobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1006183_1	1423144.Gal_01393	1.08e-47	164.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_28131_1	1211815.CBYP010000073_gene3711	6.19e-08	58.9	COG1960@1|root,COG1960@2|Bacteria,2GUCE@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
k59_583509_1	933262.AXAM01000016_gene149	6.29e-93	296.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
k59_59773_1	945713.IALB_2347	2.9e-60	209.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop
k59_942614_1	1191523.MROS_1876	1.16e-51	175.0	COG2870@1|root,COG2870@2|Bacteria	2|Bacteria	H	ADP-L-glycero-beta-D-manno-heptose biosynthetic process	rfaE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_845062_1	472759.Nhal_2510	2.57e-84	260.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales	135613|Chromatiales	C	PFAM Alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_415131_2	1131553.JIBI01000034_gene2320	4.05e-10	58.2	COG3034@1|root,COG3034@2|Bacteria,1QWAY@1224|Proteobacteria,2VUBM@28216|Betaproteobacteria,3732P@32003|Nitrosomonadales	28216|Betaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_28133_1	1283300.ATXB01000001_gene1374	9.61e-55	180.0	COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,1RN80@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Aspartyl Asparaginyl beta-hydroxylase	-	-	-	ko:K12979	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Asp_Arg_Hydrox
k59_845066_1	1123487.KB892868_gene1133	9.09e-90	268.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2VH1C@28216|Betaproteobacteria,2KUU9@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_714397_1	330214.NIDE2265	1.76e-88	275.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,3J10G@40117|Nitrospirae	40117|Nitrospirae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_125756_1	864051.BurJ1DRAFT_4826	6.67e-90	270.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2VIC9@28216|Betaproteobacteria,1KJFI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_93807_1	768671.ThimaDRAFT_2363	1.35e-53	182.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_714398_1	1121405.dsmv_2787	4.95e-215	613.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,2MI30@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_354008_1	398525.KB900701_gene7631	7.01e-10	62.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2TRPW@28211|Alphaproteobacteria,3JXN6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_280464_1	288000.BBta_1460	1.12e-118	359.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_251841_2	1122604.JONR01000032_gene74	8.8e-10	60.5	COG2770@1|root,COG2770@2|Bacteria,1QWSZ@1224|Proteobacteria,1T5DE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	HAMP domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_28148_1	1459636.NTE_02476	2.21e-89	270.0	COG2086@1|root,arCOG00446@2157|Archaea,41SX2@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_93812_1	1121448.DGI_0173	1.3e-81	255.0	2E0M7@1|root,32W6F@2|Bacteria,1NB9Z@1224|Proteobacteria,42W6T@68525|delta/epsilon subdivisions,2WSFF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_319271_1	1229909.NSED_08865	2.52e-94	285.0	arCOG08791@1|root,arCOG08791@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_59793_1	266265.Bxe_A4452	5.99e-91	280.0	COG0644@1|root,COG0644@2|Bacteria,1QM8G@1224|Proteobacteria,2VJQ9@28216|Betaproteobacteria,1K4HE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
k59_1006207_1	314278.NB231_01264	1.4e-07	52.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1WWQK@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_1006207_2	1121937.AUHJ01000001_gene771	1.08e-37	130.0	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,467VK@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Belongs to the ArsC family	yffB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
k59_774397_1	1282362.AEAC466_11570	1.18e-59	200.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,2KFBZ@204458|Caulobacterales	204458|Caulobacterales	H	glutamate--cysteine ligase	-	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
k59_1006208_1	998674.ATTE01000001_gene1371	8.84e-52	176.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1T58V@1236|Gammaproteobacteria,463WP@72273|Thiotrichales	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_875967_1	379731.PST_3429	1.05e-69	223.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,1RY10@1236|Gammaproteobacteria,1Z3TW@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_28,HTH_29,HTH_33
k59_415161_1	1206731.BAGB01000167_gene973	4.09e-34	133.0	COG2079@1|root,COG2079@2|Bacteria,2HRSH@201174|Actinobacteria,4G96A@85025|Nocardiaceae	201174|Actinobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_647636_1	1500894.JQNN01000001_gene3887	0.000136	44.3	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VNHG@28216|Betaproteobacteria,476I0@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HATPase_c_2,HisKA_3,LapD_MoxY_N,PAS,PAS_9
k59_647636_2	1175306.GWL_20380	6.62e-59	190.0	COG2197@1|root,COG2197@2|Bacteria,1RH8D@1224|Proteobacteria,2WEH4@28216|Betaproteobacteria,4778U@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	PFAM Response regulator receiver domain, Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_125777_2	1335757.SPICUR_06645	2.42e-43	157.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1WWTY@135613|Chromatiales	135613|Chromatiales	FP	Belongs to the GppA Ppx family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_875972_1	105422.BBPM01000005_gene6210	3.49e-72	229.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,2NE96@228398|Streptacidiphilus	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_N,ketoacyl-synt
k59_28161_1	767434.Fraau_0378	1.03e-111	329.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1X38C@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_28161_2	292415.Tbd_0125	5.56e-09	57.4	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,1KRI1@119069|Hydrogenophilales	119069|Hydrogenophilales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_876852_2	44454.NF84_22780	6.39e-13	68.9	COG3011@1|root,COG3011@2|Bacteria,2GMSU@201174|Actinobacteria,232YP@1762|Mycobacteriaceae	201174|Actinobacteria	S	Lipase maturation factor	LMF	-	-	-	-	-	-	-	-	-	-	-	LMF1
k59_280938_2	1046724.KB889829_gene3053	1.69e-51	182.0	COG1257@1|root,COG1577@1|root,COG1257@2|Bacteria,COG1577@2|Bacteria,1NF04@1224|Proteobacteria,1RPXQ@1236|Gammaproteobacteria,46C8E@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	GHMP kinases C terminal	-	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_386363_1	1034943.BN1094_03358	5.97e-65	214.0	COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,1RSC3@1236|Gammaproteobacteria,1JDAH@118969|Legionellales	118969|Legionellales	C	D-arabinono-1,4-lactone oxidase	-	-	-	-	-	-	-	-	-	-	-	-	ALO,FAD_binding_4
k59_386363_2	1117318.PRUB_22456	1.39e-34	132.0	COG3315@1|root,COG3315@2|Bacteria,1N2E7@1224|Proteobacteria,1SZJ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Leucine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCM
k59_846027_2	330214.NIDE0678	2.5e-10	60.8	COG2217@1|root,COG2217@2|Bacteria,3J0CY@40117|Nitrospirae	40117|Nitrospirae	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_908358_1	159087.Daro_1198	1.86e-59	201.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,2KVS9@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type Fe3 transport system, permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_159317_1	1173024.KI912151_gene1528	2.28e-102	306.0	COG1062@1|root,COG1062@2|Bacteria,1G2S4@1117|Cyanobacteria,1JHQU@1189|Stigonemataceae	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	frmA	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_354977_1	391037.Sare_1618	1.89e-27	117.0	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4DIMP@85008|Micromonosporales	201174|Actinobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_747859_1	795359.TOPB45_0842	3.73e-25	104.0	COG3897@1|root,COG3897@2|Bacteria,2GHQ3@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Lysine methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_16
k59_94751_1	411460.RUMTOR_01980	1.89e-43	154.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3XYM7@572511|Blautia	186801|Clostridia	IQ	Psort location Cytoplasmic, score	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_252707_1	1397527.Q670_03620	3.88e-67	218.0	COG0330@1|root,COG0330@2|Bacteria,1R93I@1224|Proteobacteria,1RPTI@1236|Gammaproteobacteria,1XINU@135619|Oceanospirillales	135619|Oceanospirillales	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_976355_1	96561.Dole_3030	1.87e-26	98.6	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria,2MKH5@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_976355_2	933262.AXAM01000013_gene1318	8.12e-89	281.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_223829_1	1054213.HMPREF9946_04909	6.57e-87	264.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TUVT@28211|Alphaproteobacteria,2JZE5@204441|Rhodospirillales	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1026109_1	1248916.ANFY01000018_gene1554	1.1e-15	79.7	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2TRQ1@28211|Alphaproteobacteria,2K38I@204457|Sphingomonadales	204457|Sphingomonadales	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_159327_1	1123060.JONP01000003_gene369	3.68e-53	180.0	COG3181@1|root,COG3181@2|Bacteria,1P88K@1224|Proteobacteria,2TUJU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_908370_1	330214.NIDE0737	5.83e-98	295.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_1026110_2	522306.CAP2UW1_4167	1.56e-25	102.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,1KQXC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_538367_1	335543.Sfum_0246	5.41e-35	133.0	COG2006@1|root,COG2221@1|root,COG2006@2|Bacteria,COG2221@2|Bacteria,1RABP@1224|Proteobacteria,42QQA@68525|delta/epsilon subdivisions,2WMRX@28221|Deltaproteobacteria,2MQEY@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
k59_480897_1	1469245.JFBG01000027_gene1494	7.01e-50	160.0	2CXUS@1|root,32T2P@2|Bacteria,1MZIZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YGGT
k59_480897_2	331869.BAL199_04664	1.21e-21	93.6	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,4BPV6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	yjcG	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	DUF4212,SSF
k59_584536_1	439235.Dalk_2054	4.31e-97	290.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42N5A@68525|delta/epsilon subdivisions,2WKKI@28221|Deltaproteobacteria,2MIZW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA ATPase domain	clpB1	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_747875_1	1519464.HY22_01405	1.1e-76	255.0	COG0841@1|root,COG0841@2|Bacteria,1FD8D@1090|Chlorobi	1090|Chlorobi	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_126685_1	426117.M446_0186	3.11e-11	69.3	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,dCache_1
k59_648555_1	264198.Reut_A1342	4.95e-73	241.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,1K1T6@119060|Burkholderiaceae	28216|Betaproteobacteria	KL	helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k59_252722_1	96561.Dole_2808	3.49e-37	142.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2X72U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_908379_1	452638.Pnec_1471	1.12e-17	78.6	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2VTYY@28216|Betaproteobacteria,1K9EQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_876886_1	485913.Krac_9584	2.71e-69	223.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_480902_1	936455.KI421499_gene7289	7.53e-32	118.0	COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,2TSQ1@28211|Alphaproteobacteria,3JRBU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_19265	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_451980_1	243090.RB7957	4.19e-07	52.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2IY53@203682|Planctomycetes	203682|Planctomycetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_451980_2	641146.HMPREF9020_01103	2.9e-16	78.6	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4CYVG@85004|Bifidobacteriales	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_94783_1	768710.DesyoDRAFT_2727	6.94e-10	63.5	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,263ZJ@186807|Peptococcaceae	186801|Clostridia	I	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_747889_1	568706.BN118_0062	3.72e-49	158.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,3T3XB@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_747889_2	1163617.SCD_n02562	1.87e-47	160.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_159341_1	153948.NAL212_1614	1.94e-57	193.0	COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,371PB@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
k59_943605_1	267608.RSc2524	5.02e-14	70.5	COG1994@1|root,COG1994@2|Bacteria,1PM1Q@1224|Proteobacteria,2VM3E@28216|Betaproteobacteria,1K6NE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_943605_2	267608.RSc2523	2.51e-43	150.0	COG4714@1|root,COG4714@2|Bacteria,1N40I@1224|Proteobacteria,2VNFR@28216|Betaproteobacteria,1K7HG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2167
k59_29094_1	344747.PM8797T_02689	2.59e-67	228.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2IXY9@203682|Planctomycetes	203682|Planctomycetes	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_416047_1	748280.NH8B_2245	4.71e-131	385.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,2KPJJ@206351|Neisseriales	206351|Neisseriales	E	amino acid ABC transporter	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_480913_1	391600.ABRU01000031_gene2930	8.28e-28	112.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2KFWV@204458|Caulobacterales	204458|Caulobacterales	S	Sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_19,TPR_8
k59_648572_1	497321.C664_14544	4.78e-80	243.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,2KUBI@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483,ko:K07774	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_223864_1	1121035.AUCH01000015_gene2496	1.88e-16	80.1	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,2KV9X@206389|Rhodocyclales	206389|Rhodocyclales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_223864_2	864051.BurJ1DRAFT_3958	8.05e-34	124.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,1KJK8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_482718_1	864051.BurJ1DRAFT_0123	1.84e-29	112.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VJFJ@28216|Betaproteobacteria,1KNAZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR family	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_482718_2	1175306.GWL_00240	9.35e-29	109.0	COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,2VMTP@28216|Betaproteobacteria,478FY@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_750063_1	768671.ThimaDRAFT_0867	1.76e-100	302.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1S0WJ@1236|Gammaproteobacteria,1WWFB@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
k59_1009045_1	330214.NIDE3936	1.05e-127	374.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,fn3_3
k59_878881_1	991905.SL003B_3835	1.45e-56	186.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2U22X@28211|Alphaproteobacteria,4BS1M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_388369_1	497321.C664_07293	1.06e-37	134.0	COG0107@1|root,COG0107@2|Bacteria,1QVSM@1224|Proteobacteria,2WGT7@28216|Betaproteobacteria,2KZP8@206389|Rhodocyclales	206389|Rhodocyclales	E	imidazoleglycerol-phosphate synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_193505_1	880072.Desac_0177	5.9e-05	46.6	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria,2MQ4M@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
k59_193505_2	671143.DAMO_3055	9.35e-21	92.8	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2NQQA@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	lolE-2	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_388371_1	877415.JNJQ01000042_gene2672	8.77e-11	64.7	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,3VR5F@526524|Erysipelotrichia	526524|Erysipelotrichia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A8
k59_945745_1	1283300.ATXB01000001_gene1141	3.55e-74	231.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1XE2N@135618|Methylococcales	135618|Methylococcales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_586706_1	545264.KB898745_gene1357	1.41e-85	263.0	COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1WZXR@135613|Chromatiales	135613|Chromatiales	L	COG1943 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_453938_1	216594.MMAR_4952	3.65e-28	111.0	COG1024@1|root,COG1024@2|Bacteria,2IRJ8@201174|Actinobacteria,235HP@1762|Mycobacteriaceae	201174|Actinobacteria	I	Oxidizes fatty acids using specific components catalytic activity (3S)-3-hydroxyacyl-CoA TRANS-2(or 3)-enoyl-CoA H(2)O	echA8_3	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_453938_2	593750.Metfor_2319	9.88e-16	82.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_777202_1	83406.HDN1F_09560	6.13e-16	75.9	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_777202_2	247633.GP2143_07474	7.83e-59	199.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_618285_1	323848.Nmul_A1884	1e-77	238.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,3731S@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
k59_618285_2	292415.Tbd_1904	0.000172	42.4	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,1KSZ7@119069|Hydrogenophilales	119069|Hydrogenophilales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_586722_1	1288494.EBAPG3_14780	5.74e-120	378.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,3727F@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_453952_1	1313172.YM304_01570	7.34e-87	267.0	COG0402@1|root,COG0402@2|Bacteria,2ISY0@201174|Actinobacteria	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_777213_1	745411.B3C1_14545	4.5e-61	203.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1J4HK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1027251_1	648757.Rvan_0375	7.5e-97	310.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,3N6KF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	pyruvate phosphate dikinase	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_357097_1	1532557.JL37_06165	6.36e-08	58.2	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,3T4BA@506|Alcaligenaceae	28216|Betaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	PEGA,Pkinase
k59_357097_2	1267535.KB906767_gene606	7.16e-58	205.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
k59_162366_1	485913.Krac_9375	1.39e-59	201.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_129898_1	1121438.JNJA01000016_gene1462	1.33e-26	108.0	COG1148@1|root,COG1148@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2M898@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_129898_2	1499680.CCFE01000013_gene904	9.56e-08	55.1	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,1TPG1@1239|Firmicutes,4HB2J@91061|Bacilli,1ZBAJ@1386|Bacillus	91061|Bacilli	C	COG0247 Fe-S oxidoreductase	ywjF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_651546_2	1123360.thalar_02885	6.16e-44	157.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_226842_1	1267533.KB906733_gene3384	1.81e-18	86.3	COG0773@1|root,COG0773@2|Bacteria,3Y304@57723|Acidobacteria,2JIHZ@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_226842_2	1260251.SPISAL_06820	2.21e-11	66.2	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_418852_1	1112216.JH594425_gene711	2.86e-40	152.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VF7J@28211|Alphaproteobacteria,2KDXG@204457|Sphingomonadales	204457|Sphingomonadales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,Pkinase
k59_483576_1	443143.GM18_3120	2.3e-50	178.0	COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,Hydrolase_4
k59_194526_1	1163617.SCD_n02448	1.7e-87	276.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria	28216|Betaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_226843_1	1121472.AQWN01000004_gene809	3.78e-09	55.8	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,261VF@186807|Peptococcaceae	186801|Clostridia	C	PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit	nuoE	-	1.12.1.3,1.6.5.3	ko:K00334,ko:K18330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_226843_2	498761.HM1_1028	8.47e-65	222.0	COG1894@1|root,COG1905@1|root,COG3411@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,COG3411@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_129915_1	945713.IALB_1165	1.18e-107	333.0	COG5009@1|root,COG5009@2|Bacteria	2|Bacteria	M	serine-type D-Ala-D-Ala carboxypeptidase activity	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_483580_1	395494.Galf_2455	1.13e-94	294.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,44VCR@713636|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter transmembrane region	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_389585_1	1288494.EBAPG3_5130	3.84e-70	230.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,372TA@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	lpdA	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_778097_1	309801.trd_1534	3.31e-18	85.1	COG2010@1|root,COG2010@2|Bacteria,2G9FK@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_389589_1	1380355.JNIJ01000010_gene1458	1.9e-50	177.0	COG0609@1|root,COG1120@1|root,COG0609@2|Bacteria,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2TV55@28211|Alphaproteobacteria,3JY8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_323022_1	1304883.KI912532_gene2142	3.93e-45	153.0	COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,2VJ36@28216|Betaproteobacteria,2KW1N@206389|Rhodocyclales	206389|Rhodocyclales	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_358275_1	160488.PP_3038	6.29e-29	127.0	COG4643@1|root,COG5545@1|root,COG4643@2|Bacteria,COG5545@2|Bacteria,1PEA2@1224|Proteobacteria,1SQ5G@1236|Gammaproteobacteria,1YZCT@136845|Pseudomonas putida group	1236|Gammaproteobacteria	L	Toprim domain	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	Toprim_3
k59_63703_1	1333856.L686_09265	1.86e-62	207.0	COG2199@1|root,COG2199@2|Bacteria,1R80Z@1224|Proteobacteria,1RZUV@1236|Gammaproteobacteria,1Z1UG@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	GGDEF domain	yliF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	iSBO_1134.SBO_0726	GAPES2,GGDEF
k59_795192_1	1304275.C41B8_02197	4.96e-44	151.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_795192_2	1236959.BAMT01000001_gene1068	9.52e-101	297.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,2KKPQ@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_282682_1	395019.Bmul_0484	1.57e-171	492.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,1K313@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ubiquinol oxidase, subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1027771_1	543728.Vapar_4478	1.11e-198	563.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,4AAKC@80864|Comamonadaceae	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pykA2	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_389594_2	1089551.KE386572_gene1906	2.6e-25	110.0	COG3391@1|root,COG3391@2|Bacteria,1RA6R@1224|Proteobacteria,2TX44@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_651570_1	65497.JODV01000031_gene1295	8.72e-68	218.0	COG0473@1|root,COG0473@2|Bacteria,2I8V7@201174|Actinobacteria,4DZTY@85010|Pseudonocardiales	201174|Actinobacteria	CE	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_540050_1	1121035.AUCH01000013_gene3129	1.83e-50	169.0	2B96M@1|root,322HU@2|Bacteria,1RIIU@1224|Proteobacteria,2VT7Z@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FecR
k59_651576_1	436308.Nmar_0807	1.1e-45	148.0	COG0089@1|root,arCOG04072@2157|Archaea,41SS4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_651576_2	436308.Nmar_0806	4.88e-33	117.0	COG0185@1|root,arCOG04099@2157|Archaea,41SMH@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_778110_1	399795.CtesDRAFT_PD4156	1.46e-06	49.7	COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2VIAD@28216|Betaproteobacteria,4A9Z7@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3422)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
k59_778110_2	76114.ebB157	2.23e-29	107.0	2CC6G@1|root,32Y5Q@2|Bacteria,1N79B@1224|Proteobacteria,2VX3K@28216|Betaproteobacteria,2KX80@206389|Rhodocyclales	206389|Rhodocyclales	S	lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BLIP
k59_778110_3	1458357.BG58_07865	4.07e-16	75.1	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,1JZYT@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
k59_358301_2	257313.BP0233	2.48e-44	156.0	COG1802@1|root,COG1802@2|Bacteria,1RDQP@1224|Proteobacteria,2WEIB@28216|Betaproteobacteria,3T8KE@506|Alcaligenaceae	28216|Betaproteobacteria	K	FCD domain	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_911403_1	105559.Nwat_0663	4.63e-99	305.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_455032_2	671143.DAMO_1524	2.2e-96	288.0	COG0682@1|root,COG0682@2|Bacteria,2NPK2@2323|unclassified Bacteria	2|Bacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.199	ko:K03438,ko:K13292	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	LGT
k59_619341_1	1288494.EBAPG3_15690	2.15e-165	473.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,372Q1@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_619341_2	1265313.HRUBRA_01814	1.71e-05	46.6	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1J4Y8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes	sucA	GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1010080_1	933262.AXAM01000032_gene690	1.17e-45	158.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2WJB8@28221|Deltaproteobacteria,2MHR6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1010080_2	399739.Pmen_3801	1.62e-06	48.5	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1YDGR@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.5.4.4	ko:K00969,ko:K01488	ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340	M00115	R00137,R01560,R02556,R03005	RC00002,RC00477	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612	CTP_transf_like
k59_619343_1	1232683.ADIMK_2380	5.45e-42	144.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,466E7@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the UPF0758 family	radC	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_619343_2	56780.SYN_02177	2.21e-11	63.9	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2WIR1@28221|Deltaproteobacteria,2MQ4I@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_129973_1	690585.JNNU01000016_gene2691	4.9e-22	100.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4B7WC@82115|Rhizobiaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_226913_1	1191523.MROS_0328	1.63e-39	144.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	dtpD	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1,PTR2
k59_483634_1	398767.Glov_2149	8.5e-43	151.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,42MH0@68525|delta/epsilon subdivisions,2WJZ7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_418914_1	1211114.ALIP01000116_gene2648	8.51e-81	256.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1X3IH@135614|Xanthomonadales	135614|Xanthomonadales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_911436_1	93220.LV28_19865	5.15e-05	47.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VZ5S@28216|Betaproteobacteria,1K5W9@119060|Burkholderiaceae	28216|Betaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_911436_2	1038859.AXAU01000026_gene2331	2.75e-87	265.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRS8@28211|Alphaproteobacteria,3JS1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	nikB	-	-	ko:K02033,ko:K15585	ko02010,ko02024,map02010,map02024	M00239,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_63762_1	768671.ThimaDRAFT_0808	3.88e-92	283.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1WXN7@135613|Chromatiales	135613|Chromatiales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_1010099_1	153948.NAL212_0970	1.49e-24	103.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria,372M4@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	Nucleoside H+ symporter	hcaT	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_862285_1	330214.NIDE2666	2.12e-71	220.0	COG2096@1|root,COG2096@2|Bacteria	2|Bacteria	S	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	yvqK	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.2.1.88,1.5.5.2,2.5.1.17	ko:K00798,ko:K13821	ko00250,ko00330,ko00860,ko01100,ko01110,ko01130,map00250,map00330,map00860,map01100,map01110,map01130	M00122	R00245,R00707,R00708,R01253,R01492,R04444,R04445,R05051,R05220,R07268	RC00080,RC00083,RC00216,RC00242,RC00255,RC00533	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	Cob_adeno_trans
k59_373534_2	395494.Galf_2722	1.12e-52	171.0	28WAT@1|root,2ZIB9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_438835_1	391625.PPSIR1_41749	3.9e-67	218.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,431ET@68525|delta/epsilon subdivisions,2WWV2@28221|Deltaproteobacteria,2YX5R@29|Myxococcales	28221|Deltaproteobacteria	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
k59_733735_1	945713.IALB_3192	2.17e-98	318.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13,2.1.1.245,2.1.1.258	ko:K00197,ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00680,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00357,M00377,M00422	R00946,R02289,R09096,R09365,R10219,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_788575_1	404589.Anae109_4208	6.11e-06	53.9	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42MJ7@68525|delta/epsilon subdivisions,2WIRS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM amidohydrolase	-	-	3.5.4.40	ko:K20810	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_570435_2	945713.IALB_0627	4.03e-35	130.0	COG1105@1|root,COG1105@2|Bacteria	2|Bacteria	H	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.11,2.7.1.144,2.7.1.56	ko:K00882,ko:K00917,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_113110_1	1276756.AUEX01000004_gene2397	2.28e-76	243.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,4A9ZE@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FAD dependent oxidoreductase	dad2	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2
k59_307799_1	1265502.KB905929_gene2238	3.95e-26	101.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2VIMU@28216|Betaproteobacteria,4AB9C@80864|Comamonadaceae	28216|Betaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_307799_2	637390.AFOH01000047_gene2024	1.54e-25	102.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,2NCQY@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_831866_1	983917.RGE_28240	1.11e-89	288.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1KJJS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_929644_1	111780.Sta7437_3167	2.94e-14	75.1	COG0500@1|root,COG2226@2|Bacteria,1G3V3@1117|Cyanobacteria,3VKIZ@52604|Pleurocapsales	1117|Cyanobacteria	Q	COGs COG2226 Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_404170_1	292415.Tbd_0872	6.98e-80	255.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria,1KS3F@119069|Hydrogenophilales	119069|Hydrogenophilales	C	FAD binding domain	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_145784_1	228410.NE1398	2.52e-50	166.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,37236@32003|Nitrosomonadales	28216|Betaproteobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_145784_2	323848.Nmul_A2119	6.65e-59	188.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2VHT5@28216|Betaproteobacteria,372KE@32003|Nitrosomonadales	28216|Betaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_993874_1	375286.mma_0396	0.000815	42.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,476QA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_993874_2	1005048.CFU_2015	2.21e-62	196.0	COG0664@1|root,COG0664@2|Bacteria,1R64V@1224|Proteobacteria,2VJXN@28216|Betaproteobacteria,472QZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_831873_1	987059.RBXJA2T_13439	3.02e-33	117.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2VUY1@28216|Betaproteobacteria,1KMF8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM Membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_831873_2	864051.BurJ1DRAFT_4938	1.03e-17	84.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1KKB2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Peptidase family M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_1019382_1	713586.KB900536_gene2689	3.49e-29	119.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria,1WVUT@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_1019382_2	42256.RradSPS_0982	0.000479	41.6	COG1006@1|root,COG1006@2|Bacteria,2GSHQ@201174|Actinobacteria	201174|Actinobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_570462_1	1459636.NTE_00015	3.53e-48	163.0	COG1976@1|root,arCOG04176@2157|Archaea,41SIP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
k59_113126_1	225117.XP_009339929.1	3.18e-38	137.0	COG0194@1|root,KOG0707@2759|Eukaryota,37RE3@33090|Viridiplantae,3G9GT@35493|Streptophyta,4JENB@91835|fabids	35493|Streptophyta	F	Guanylate	-	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009507,GO:0009536,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040008,GO:0042278,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0048638,GO:0050145,GO:0050789,GO:0050793,GO:0055086,GO:0065007,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_505205_1	702113.PP1Y_Mpl5263	1.96e-31	125.0	COG1629@1|root,COG4771@2|Bacteria,1R5XT@1224|Proteobacteria,2U4AA@28211|Alphaproteobacteria,2K9PP@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_929662_1	511062.GU3_07815	1.01e-104	315.0	COG1292@1|root,COG1292@2|Bacteria,1MWXP@1224|Proteobacteria,1RQMC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1292 Choline-glycine betaine transporter	-	-	-	-	-	-	-	-	-	-	-	-	BCCT
k59_701373_1	1121875.KB907548_gene1485	6.48e-36	134.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,HATPase_c,HTH_18,HisKA,PKD,Reg_prop,Response_reg,Y_Y_Y
k59_240959_1	768670.Calni_1475	5.49e-14	74.3	COG0001@1|root,COG0001@2|Bacteria,2GEN5@200930|Deferribacteres	200930|Deferribacteres	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_240959_2	1193128.A200_06774	2.12e-08	57.8	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4CZ77@85004|Bifidobacteriales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_307832_1	1122939.ATUD01000003_gene3282	2.83e-13	68.6	COG1611@1|root,COG1611@2|Bacteria,2GMM1@201174|Actinobacteria,4CSTC@84995|Rubrobacteria	84995|Rubrobacteria	F	Possible lysine decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lysine_decarbox
k59_307832_2	926569.ANT_04530	1.07e-26	108.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi	200795|Chloroflexi	O	ATPase AAA-2 domain protein	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,HTH_17,UVR
k59_373589_1	1198232.CYCME_1862	3.46e-29	121.0	COG0784@1|root,COG5001@1|root,COG0784@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,4620Q@72273|Thiotrichales	72273|Thiotrichales	T	Diguanylate cyclase phosphodiesterase (GGDEF EAL domains) with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
k59_788585_2	497321.C664_11390	2.34e-161	469.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,2KUXG@206389|Rhodocyclales	206389|Rhodocyclales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_307842_1	335283.Neut_2154	7.93e-84	266.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,371S5@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_831910_1	1286093.C266_15197	1.32e-64	213.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,1K1TG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_469370_2	330214.NIDE2820	2.56e-14	70.5	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	tklG	-	-	ko:K10927	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	-
k59_145830_1	709986.Deima_1166	3.47e-38	147.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_733802_1	180281.CPCC7001_2735	3.76e-173	495.0	COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,22TNQ@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_635236_1	713587.THITH_07785	3.61e-95	291.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria,1WYW4@135613|Chromatiales	135613|Chromatiales	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_863428_1	604354.TSIB_1593	2.95e-05	47.4	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,242VP@183968|Thermococci	183968|Thermococci	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k59_178405_2	1286631.X805_28170	3.93e-67	216.0	COG0679@1|root,COG0679@2|Bacteria,1PINE@1224|Proteobacteria,2VIH3@28216|Betaproteobacteria,1KKEN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_701413_1	1395571.TMS3_0124685	5.55e-06	47.4	COG3193@1|root,COG3193@2|Bacteria,1RH9E@1224|Proteobacteria,1SAUP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_701413_2	1038859.AXAU01000002_gene322	5.49e-64	205.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria,3JSAU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_505242_1	768671.ThimaDRAFT_3410	1.17e-48	160.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1WY4S@135613|Chromatiales	135613|Chromatiales	P	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
k59_505242_2	580332.Slit_1790	2.86e-05	49.3	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,44V8W@713636|Nitrosomonadales	28216|Betaproteobacteria	O	TIGRFAM cytochrome c-type biogenesis protein CcmI	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
k59_993928_1	880072.Desac_2721	1.19e-51	177.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2MQRN@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_570511_1	1283300.ATXB01000002_gene2925	2.77e-73	239.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XE1B@135618|Methylococcales	135618|Methylococcales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_47714_1	1234364.AMSF01000066_gene2273	1.16e-60	201.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1X31X@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf-QO	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
k59_47714_2	1123227.KB899340_gene1402	6.49e-19	83.2	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,2JPSB@204441|Rhodospirillales	204441|Rhodospirillales	C	Electron transfer flavoprotein, beta subunit	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_307864_1	795666.MW7_2236	1.36e-115	360.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,1K1J9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_341506_1	935557.ATYB01000014_gene2757	4.56e-52	178.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,4BC7V@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,rve,rve_3
k59_570524_1	1191523.MROS_0623	2.83e-30	123.0	COG1138@1|root,COG1138@2|Bacteria	2|Bacteria	O	Cytochrome C-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_962298_1	292415.Tbd_0798	1.02e-31	121.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,1KRHA@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Lipid-A-disaccharide synthetase	-	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_962298_2	1454004.AW11_01617	5.95e-93	281.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,1KPN9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_962298_3	1288494.EBAPG3_700	2.43e-67	208.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2VRKQ@28216|Betaproteobacteria,37315@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_962298_4	1163617.SCD_n01625	5.56e-69	220.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_701436_1	1286631.X805_02270	1.83e-129	375.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VIFE@28216|Betaproteobacteria,1KJ50@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_831952_1	489825.LYNGBM3L_05790	7.31e-72	230.0	COG0161@1|root,COG0161@2|Bacteria,1G1QE@1117|Cyanobacteria,1H9SQ@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.18,2.6.1.62	ko:K00822,ko:K00833	ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100	M00123,M00573,M00577	R00907,R03231,R04187	RC00006,RC00008,RC00062,RC00160,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_80912_1	246197.MXAN_3415	7.32e-62	213.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales	28221|Deltaproteobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_404235_1	1038860.AXAP01000101_gene5274	3.3e-188	545.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_373648_1	977880.RALTA_A3016	1.78e-153	449.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1K2Y9@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C
k59_635278_1	1454004.AW11_02176	1.6e-07	50.4	2BECK@1|root,3283Q@2|Bacteria,1RKSC@1224|Proteobacteria,2VS57@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
k59_635278_2	1454004.AW11_02175	7.48e-45	160.0	COG3497@1|root,COG3497@2|Bacteria,1R7FA@1224|Proteobacteria,2VMDF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	tail sheath protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_404244_1	1247726.MIM_c25930	2.25e-92	280.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,3T2SF@506|Alcaligenaceae	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_733854_1	1134474.O59_000283	2.77e-68	229.0	COG4225@1|root,COG4225@2|Bacteria,1MU2J@1224|Proteobacteria,1RR65@1236|Gammaproteobacteria,1FFXX@10|Cellvibrio	1236|Gammaproteobacteria	S	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	DUF4861,Glyco_hydro_88
k59_763251_1	436229.JOEH01000011_gene5421	3.2e-18	92.4	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,2NG2S@228398|Streptacidiphilus	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	fadE6_1	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_763251_2	595460.RRSWK_01251	8.18e-08	53.5	COG5587@1|root,COG5587@2|Bacteria,2J2RK@203682|Planctomycetes	203682|Planctomycetes	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
k59_602843_1	1101190.ARWB01000001_gene3277	0.000484	42.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria,36ZVF@31993|Methylocystaceae	28211|Alphaproteobacteria	F	Pyrimidine nucleoside phosphorylase C-terminal domain	deoA	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_602843_2	395495.Lcho_3013	3.88e-114	346.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VK5J@28216|Betaproteobacteria,1KJPS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5	ko:K01081,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_469416_1	1123368.AUIS01000009_gene2449	2.9e-90	276.0	COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,1RPGR@1236|Gammaproteobacteria,2NCP1@225057|Acidithiobacillales	225057|Acidithiobacillales	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
k59_763254_1	330214.NIDE0360	1.09e-96	299.0	COG0706@1|root,COG0706@2|Bacteria,3J0GD@40117|Nitrospirae	40117|Nitrospirae	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_373664_1	522306.CAP2UW1_0737	8.81e-67	218.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KQCV@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	hoxA	-	-	ko:K19641	ko02020,map02020	M00772	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_733863_1	1144319.PMI16_01386	5.09e-102	306.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2W9AN@28216|Betaproteobacteria,477ZK@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.2.2	ko:K01781	ko00627,ko01120,map00627,map01120	-	R03791,R04161	RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_15544_1	1454004.AW11_03608	9.07e-35	134.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1KQKC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Sodium/hydrogen exchanger family	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_241020_1	1442599.JAAN01000014_gene3581	2.02e-82	258.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1X3HB@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_145899_1	272560.BPSL3133	1.33e-81	249.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,1K0MT@119060|Burkholderiaceae	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_602850_1	748247.AZKH_4332	6.33e-59	194.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,2KUXF@206389|Rhodocyclales	206389|Rhodocyclales	GM	epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_602850_2	1288494.EBAPG3_27690	1.1e-97	307.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,371PH@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Soluble lytic murein transglycosylase L domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_701481_1	330214.NIDE3144	1.39e-83	251.0	COG1974@1|root,COG1974@2|Bacteria,3J1C0@40117|Nitrospirae	40117|Nitrospirae	K	Represses a number of genes involved in the response to DNA damage (SOS response)	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	Peptidase_S24
k59_570575_1	1304885.AUEY01000001_gene3176	4.85e-41	149.0	COG1609@1|root,COG1609@2|Bacteria,1R5GE@1224|Proteobacteria,42R8F@68525|delta/epsilon subdivisions,2WMTS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
k59_146787_2	1095769.CAHF01000011_gene2283	5.37e-34	121.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2VQFV@28216|Betaproteobacteria,474FZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_514496_1	439235.Dalk_2316	6.93e-115	343.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2MHSH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,R3H
k59_644201_1	999541.bgla_1g33400	3.57e-14	71.6	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,1K06K@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_644201_2	882378.RBRH_01237	8.44e-97	289.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,1K2NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_743220_1	1304883.KI912532_gene826	3.87e-72	234.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,2KUBX@206389|Rhodocyclales	206389|Rhodocyclales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_477150_2	713587.THITH_14450	1.85e-31	122.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales	135613|Chromatiales	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_350501_2	1082933.MEA186_26491	1.02e-139	400.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,43NIW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_24639_1	1472912.A0A023NH00_9CAUD	1.19e-32	122.0	4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses  no RNA stage,4QPEB@28883|Caudovirales	28883|Caudovirales	S	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_904096_1	748247.AZKH_0785	6.13e-50	165.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,2KW8U@206389|Rhodocyclales	206389|Rhodocyclales	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_904096_2	196367.JNFG01000018_gene4370	2.29e-49	166.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1K25Z@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_382193_1	521011.Mpal_0644	1.64e-45	161.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_412169_2	76114.ebA2945	1.34e-70	218.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales	206389|Rhodocyclales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_24646_1	1266925.JHVX01000026_gene1428	6.17e-54	183.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,373UJ@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_219575_1	748247.AZKH_3188	1.06e-144	419.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,2KV4N@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_278601_2	757424.Hsero_3842	1.68e-36	123.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,474ZG@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Rubredoxin	rubA	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
k59_743236_1	40149.OMERI04G17390.1	2.66e-15	79.0	COG1028@1|root,KOG0725@2759|Eukaryota	2759|Eukaryota	IQ	oxidation-reduction process	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_155015_1	765914.ThisiDRAFT_0399	2.16e-13	68.9	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_155015_2	349124.Hhal_2340	2.3e-44	145.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_904108_1	864051.BurJ1DRAFT_3441	3.86e-92	286.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VM62@28216|Betaproteobacteria,1KIUI@119065|unclassified Burkholderiales	1224|Proteobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
k59_939073_1	1392498.JQLH01000001_gene2859	7.11e-38	140.0	COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,1HX9D@117743|Flavobacteriia,2PIMW@252356|Maribacter	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH
k59_219585_1	1168034.FH5T_12380	1.27e-33	123.0	COG0491@1|root,COG0491@2|Bacteria,4NE2Y@976|Bacteroidetes,2FSQ1@200643|Bacteroidia	976|Bacteroidetes	P	Metallo-beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_155026_1	1125699.HMPREF9194_01459	3.22e-25	105.0	COG1178@1|root,COG1178@2|Bacteria,2J7A4@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_155026_2	272942.RCAP_rcc02183	1.28e-36	135.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,1FAXQ@1060|Rhodobacter	28211|Alphaproteobacteria	P	Part of the ABC transporter complex FbpABC involved in Fe(3 ) ions import. Responsible for energy coupling to the transport system	fbpC	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
k59_350528_1	1232410.KI421428_gene988	1.59e-51	173.0	COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,1MVJX@1224|Proteobacteria,42MEZ@68525|delta/epsilon subdivisions,2WIUW@28221|Deltaproteobacteria,43S6Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	cbiET	-	2.1.1.132	ko:K00595	ko00860,ko01100,map00860,map01100	-	R05149	RC00003,RC01279	ko00000,ko00001,ko01000	-	-	-	Cons_hypoth95,Methyltransf_31,Methyltransf_4,PCMT,TP_methylase
k59_644233_1	945713.IALB_0473	4.5e-123	381.0	COG0060@1|root,COG0060@2|Bacteria	2|Bacteria	J	isoleucyl-tRNA aminoacylation	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_841430_1	1454004.AW11_02472	3.79e-61	205.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,1KQBH@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	AMP-binding enzyme	bclA_2	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_743254_2	1100720.ALKN01000007_gene2915	2.66e-113	338.0	COG1638@1|root,COG1638@2|Bacteria,1PMWE@1224|Proteobacteria,2VNJI@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_382228_1	526227.Mesil_3264	7.04e-84	263.0	COG4949@1|root,COG4949@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3422)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
k59_971748_1	471857.Svir_20710	5.81e-42	151.0	COG0654@1|root,COG0654@2|Bacteria,2GIZU@201174|Actinobacteria,4DXIV@85010|Pseudonocardiales	201174|Actinobacteria	CH	FAD binding domain	-	GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016709,GO:0018669,GO:0019439,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044248,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.14.13.24	ko:K22270	ko00362,ko01120,map00362,map01120	-	R02589	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
k59_248919_1	1535422.ND16A_2068	0.000102	49.3	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_447724_1	1288963.ADIS_4244	1.05e-54	195.0	COG0457@1|root,COG0457@2|Bacteria,4NIBU@976|Bacteroidetes,47P3K@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5107,TPR_16,TPR_6,TPR_8
k59_382242_1	983917.RGE_39410	3.81e-36	140.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria	28216|Betaproteobacteria	NT	chemotaxis	-	-	-	ko:K03406,ko:K03776,ko:K05875	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_3,sCache_2
k59_219618_1	909663.KI867151_gene3008	4.4e-111	330.0	COG0463@1|root,COG0463@2|Bacteria,1R547@1224|Proteobacteria,42PDC@68525|delta/epsilon subdivisions,2WKYW@28221|Deltaproteobacteria,2MR35@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	glycosyl transferase family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
k59_382246_1	398525.KB900701_gene1045	7.42e-62	201.0	COG0673@1|root,COG0673@2|Bacteria,1MU8F@1224|Proteobacteria,2U12U@28211|Alphaproteobacteria,3JX1N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_412217_1	391596.PBAL39_10885	3.11e-08	53.9	COG1011@1|root,COG1011@2|Bacteria,4NMJY@976|Bacteroidetes,1IS9Y@117747|Sphingobacteriia	976|Bacteroidetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
k59_678099_1	864051.BurJ1DRAFT_2680	4.21e-72	236.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,1KITN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	PFAM Orn Lys Arg decarboxylase	adi	-	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
k59_219624_1	926569.ANT_30500	4.18e-81	267.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_56420_1	314264.ROS217_00955	5.15e-82	257.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U0EE@28211|Alphaproteobacteria,46RTP@74030|Roseovarius	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_536160_1	1304885.AUEY01000029_gene2489	8.4e-84	254.0	COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WIRY@28221|Deltaproteobacteria,2MI8X@213118|Desulfobacterales	28221|Deltaproteobacteria	ET	SMART ABC-type transporter, periplasmic subunit family 3, ionotropic glutamate receptor	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_939120_1	1163617.SCD_n00192	7.53e-58	190.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2VHHC@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
k59_710918_1	706587.Desti_2452	7.88e-84	258.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_382257_2	1121440.AUMA01000004_gene2775	3.61e-14	72.8	COG4381@1|root,COG4381@2|Bacteria,1N954@1224|Proteobacteria,430E3@68525|delta/epsilon subdivisions,2WVTH@28221|Deltaproteobacteria,2MCQV@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Phage protein GP46	-	-	-	-	-	-	-	-	-	-	-	-	GP46
k59_155075_1	2340.JV46_20160	7.75e-103	322.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	copA	GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035434,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060003,GO:0061687,GO:0070887,GO:0071241,GO:0071248,GO:0071280,GO:0071292,GO:0071944,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:1902601,GO:1990169	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iEC55989_1330.EC55989_0497,iECIAI1_1343.ECIAI1_0487,iECO103_1326.ECO103_0460,iECSE_1348.ECSE_0509,iECW_1372.ECW_m0557,iEKO11_1354.EKO11_3363,iWFL_1372.ECW_m0557	E1-E2_ATPase,HMA,Hydrolase
k59_939133_1	1454004.AW11_03028	1.78e-110	326.0	COG2220@1|root,COG2220@2|Bacteria,1R5GU@1224|Proteobacteria,2VPH1@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_382260_1	1232410.KI421426_gene1487	2.26e-67	219.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,43T0A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_350587_1	1123392.AQWL01000001_gene1449	4.8e-71	238.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1KRBT@119069|Hydrogenophilales	119069|Hydrogenophilales	CM	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
k59_611915_1	1304874.JAFY01000007_gene2078	8.77e-66	210.0	COG3039@1|root,COG3039@2|Bacteria,3TBCF@508458|Synergistetes	508458|Synergistetes	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_971797_1	1268072.PSAB_13670	6.06e-16	82.4	COG0624@1|root,COG0624@2|Bacteria,1TQS9@1239|Firmicutes,4HDHW@91061|Bacilli,26UDI@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase family M20/M25/M40	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_644291_1	272560.BPSL0539	3.47e-07	52.4	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1K1JT@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_644291_2	391038.Bphy_0331	2.44e-82	254.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,1K0GY@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_350591_1	398578.Daci_1953	4.39e-40	149.0	28S81@1|root,2ZEJD@2|Bacteria,1RCNN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_187113_1	556261.HMPREF0240_00940	2.38e-08	54.7	COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,24MN9@186801|Clostridia,36KRW@31979|Clostridiaceae	186801|Clostridia	S	protein with conserved CXXC pairs	-	-	-	-	-	-	-	-	-	-	-	-	DUF1667
k59_743319_1	1266925.JHVX01000006_gene2084	2.56e-63	218.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,371SD@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_248973_1	350058.Mvan_3037	1.43e-22	103.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,2353H@1762|Mycobacteriaceae	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_515586_1	1123073.KB899244_gene400	1.34e-11	64.3	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1X4EN@135614|Xanthomonadales	135614|Xanthomonadales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_515586_2	1122236.KB905145_gene2431	4.68e-153	443.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,2KM45@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_413138_1	379066.GAU_1789	6.52e-35	136.0	COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1ZSKI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_940109_1	316407.85676869	1.25e-102	320.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,1RMVF@1236|Gammaproteobacteria,3XNRQ@561|Escherichia	1236|Gammaproteobacteria	E	Biodegradative arginine decarboxylase	adiA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0006873,GO:0006885,GO:0008144,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019725,GO:0019752,GO:0019842,GO:0030003,GO:0030004,GO:0030170,GO:0030641,GO:0036094,GO:0042592,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0045852,GO:0046395,GO:0048037,GO:0048878,GO:0050662,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:0098771,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_4483	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
k59_478093_1	1171373.PACID_00030	9.61e-09	62.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4DWZ8@85009|Propionibacteriales	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_679128_1	420324.KI912020_gene7461	3.82e-64	211.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_26940	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_279152_1	118168.MC7420_8161	2.69e-67	212.0	COG0572@1|root,COG0572@2|Bacteria,1G67K@1117|Cyanobacteria,1HC0C@1150|Oscillatoriales	1117|Cyanobacteria	F	uridine kinase	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
k59_25688_1	243233.MCA2768	1.76e-90	280.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1XE4R@135618|Methylococcales	135618|Methylococcales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_123326_1	2340.JV46_13040	2.62e-139	407.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J85H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
k59_123326_2	2340.JV46_13030	8.04e-11	61.6	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_515607_1	102129.Lepto7375DRAFT_1004	1.66e-111	336.0	COG3039@1|root,COG3039@2|Bacteria,1GCCT@1117|Cyanobacteria	1117|Cyanobacteria	L	COG3039 Transposase and inactivated derivatives, IS5 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_612899_1	987059.RBXJA2T_16207	4.2e-15	69.7	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,1KM9K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	phosphocarrier protein HPr	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_612899_2	864051.BurJ1DRAFT_0469	3.58e-12	66.2	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,1KJSR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_448717_1	998674.ATTE01000001_gene1740	1.74e-71	228.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,46068@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_711928_1	1121405.dsmv_3355	1.13e-46	160.0	COG0642@1|root,COG2205@2|Bacteria,1RK25@1224|Proteobacteria,42T3D@68525|delta/epsilon subdivisions,2WMAT@28221|Deltaproteobacteria,2MI6G@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_57422_2	113395.AXAI01000004_gene4185	3.66e-10	59.7	2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2TTH2@28211|Alphaproteobacteria,3JUFR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1024386_1	1458275.AZ34_16295	5.08e-116	349.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2VI17@28216|Betaproteobacteria,4ACCU@80864|Comamonadaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_91312_1	266264.Rmet_1533	1.04e-100	300.0	COG2042@1|root,COG3376@2|Bacteria,1MUYH@1224|Proteobacteria,2VJDC@28216|Betaproteobacteria,1K07W@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the NiCoT transporter (TC 2.A.52) family	hoxN	-	-	ko:K07241	-	-	-	-	ko00000,ko02000	2.A.52.1	-	-	NicO
k59_25706_1	1279038.KB907350_gene2871	6.66e-61	195.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2TUF3@28211|Alphaproteobacteria,2JRYH@204441|Rhodospirillales	204441|Rhodospirillales	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_972812_1	501479.ACNW01000096_gene921	1.75e-96	312.0	COG0457@1|root,COG2931@1|root,COG0457@2|Bacteria,COG2931@2|Bacteria,1NB3F@1224|Proteobacteria,2UH7R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_873533_1	330214.NIDE1308	1.09e-104	322.0	COG0480@1|root,COG0480@2|Bacteria,3J0EK@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_25707_1	945713.IALB_0808	9.05e-90	276.0	COG0439@1|root,COG0439@2|Bacteria	2|Bacteria	I	biotin carboxylase activity	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_324691_1	887062.HGR_16725	7.82e-128	372.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,4AAZY@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_484935_1	342949.PNA2_0717	3.99e-21	88.2	arCOG11950@1|root,arCOG11950@2157|Archaea,2Y6QN@28890|Euryarchaeota,2452S@183968|Thermococci	183968|Thermococci	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_3
k59_779487_1	706587.Desti_2522	7.03e-117	358.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria,2MRCW@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Cytochrome C and Quinol oxidase polypeptide I	norZ	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_1011579_1	1286632.P278_31310	2.55e-70	230.0	28HMZ@1|root,2Z7WD@2|Bacteria,4P095@976|Bacteroidetes	2|Bacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_795818_2	583345.Mmol_0474	7.1e-18	85.5	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,2KNNY@206350|Nitrosomonadales	206350|Nitrosomonadales	V	ABC transporter transmembrane region	-	-	-	ko:K11004	ko02010,ko03070,ko05133,map02010,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2	-	-	ABC_membrane,ABC_tran
k59_391472_1	1266925.JHVX01000010_gene1328	4.27e-107	331.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,3727H@32003|Nitrosomonadales	28216|Betaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_456827_1	1120999.JONM01000006_gene2366	1.54e-15	70.9	COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,2KS14@206351|Neisseriales	206351|Neisseriales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
k59_456827_2	159087.Daro_3506	8.74e-34	125.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,2KUQH@206389|Rhodocyclales	206389|Rhodocyclales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_912880_1	1120999.JONM01000003_gene2553	6.53e-109	331.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,2KPE2@206351|Neisseriales	206351|Neisseriales	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_283517_1	323848.Nmul_A2083	4.38e-52	180.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,3724J@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_420303_1	861299.J421_3221	1.84e-43	155.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,1ZT4Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IM	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	-	3.5.1.108,4.2.1.59	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
k59_1011613_1	557599.MKAN_08310	1.25e-34	132.0	COG0446@1|root,COG0446@2|Bacteria,2I4HJ@201174|Actinobacteria,23F7X@1762|Mycobacteriaceae	201174|Actinobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_1011615_1	202952.BBLI01000001_gene89	3.65e-75	242.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,3NJM2@468|Moraxellaceae	1236|Gammaproteobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	glpD	GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009331,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0022900,GO:0031224,GO:0031226,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046168,GO:0046434,GO:0048037,GO:0050660,GO:0050662,GO:0052590,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575,GO:1902494,GO:1990204	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	iSSON_1240.SSON_3663	DAO,DAO_C
k59_779525_1	865937.Gilli_3289	1.68e-15	71.6	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,1I2XY@117743|Flavobacteriia,2P6Z2@244698|Gillisia	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_779525_2	865937.Gilli_3252	4.82e-15	69.7	2DI4K@1|root,3020V@2|Bacteria,4NV1J@976|Bacteroidetes,1I507@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_779525_3	1461577.CCMH01000009_gene1595	1.29e-13	66.6	COG0607@1|root,COG0607@2|Bacteria,4NSD1@976|Bacteroidetes,1I53P@117743|Flavobacteriia	976|Bacteroidetes	P	Sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_256920_1	987059.RBXJA2T_12292	6.81e-86	266.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,1KJV2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_881479_1	555778.Hneap_0412	1.54e-87	271.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1RRMU@1236|Gammaproteobacteria,1X26N@135613|Chromatiales	135613|Chromatiales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_283549_1	1121396.KB893090_gene261	4.29e-45	150.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42R2A@68525|delta/epsilon subdivisions,2WMUK@28221|Deltaproteobacteria,2MJJX@213118|Desulfobacterales	28221|Deltaproteobacteria	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_256963_1	1266925.JHVX01000005_gene1882	1.93e-120	370.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,3720Z@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Competence protein ComEC Rec2	comA	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_391579_2	438753.AZC_4188	2.43e-55	176.0	COG1917@1|root,COG1917@2|Bacteria,1RDWP@1224|Proteobacteria,2U7BQ@28211|Alphaproteobacteria,3F1E3@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
k59_420367_1	1207063.P24_02141	9.59e-94	283.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,2JQ3C@204441|Rhodospirillales	204441|Rhodospirillales	P	transport system, permease component	-	-	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
k59_456919_1	519989.ECTPHS_06707	1.31e-104	323.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_391585_1	1121012.AUKX01000035_gene810	6.79e-40	149.0	COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,1I0PW@117743|Flavobacteriia,23GNR@178469|Arenibacter	976|Bacteroidetes	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_456920_1	398578.Daci_5772	5.65e-10	64.7	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VM1F@28216|Betaproteobacteria,4AIY8@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM ABC transporter related	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k59_912964_1	335543.Sfum_4092	2.31e-18	81.3	COG1150@1|root,COG1150@2|Bacteria,1NFJN@1224|Proteobacteria,43B2A@68525|delta/epsilon subdivisions,2X6GB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_17
k59_256974_1	414684.RC1_2884	1.55e-30	117.0	COG4094@1|root,COG4094@2|Bacteria,1RDV6@1224|Proteobacteria,2U609@28211|Alphaproteobacteria,2JSHA@204441|Rhodospirillales	204441|Rhodospirillales	S	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU
k59_391596_1	717773.Thicy_0986	2.6e-56	187.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,45ZWD@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1011680_1	287.DR97_1242	1.42e-13	74.7	COG1226@1|root,32Y28@2|Bacteria,1MYY3@1224|Proteobacteria	1224|Proteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_456938_1	1163409.UUA_08311	7.03e-74	234.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1X32A@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	pcaF	-	2.3.1.174	ko:K07823	ko00362,ko01120,map00362,map01120	-	R00829	RC00004,RC00326	ko00000,ko00001,ko01000	-	-	-	Thiolase_C,Thiolase_N
k59_324851_1	883.DvMF_3082	2.66e-60	199.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2WMYV@28221|Deltaproteobacteria,2M8UK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_485063_1	694427.Palpr_0340	0.000124	45.1	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,4NGSQ@976|Bacteroidetes,2FM60@200643|Bacteroidia,22W01@171551|Porphyromonadaceae	976|Bacteroidetes	GKT	Pyruvate phosphate dikinase, PEP pyruvate binding domain	ppsA	-	-	-	-	-	-	-	-	-	-	-	PPDK_N,Response_reg
k59_485063_2	1379698.RBG1_1C00001G0407	2.27e-20	93.2	COG0823@1|root,COG0823@2|Bacteria,2NQA4@2323|unclassified Bacteria	2|Bacteria	U	Periplasmic component of the Tol biopolymer transport system	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PA,PD40,PDZ_2,Peptidase_M28
k59_540949_1	1380394.JADL01000014_gene203	1.32e-100	308.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2U1QF@28211|Alphaproteobacteria,2JVYJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Fumarate reductase flavoprotein C-term	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_779613_1	998088.B565_2051	2.52e-38	133.0	COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,1S61S@1236|Gammaproteobacteria,1Y5V7@135624|Aeromonadales	135624|Aeromonadales	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
k59_779613_2	883078.HMPREF9695_03197	9.01e-62	201.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,3JU2P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	ivd2	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_456968_1	1007105.PT7_0050	1.59e-99	317.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,3T227@506|Alcaligenaceae	28216|Betaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1011717_1	1095769.CAHF01000022_gene339	2.46e-80	253.0	COG4966@1|root,COG4966@2|Bacteria,1RC4Q@1224|Proteobacteria,2VS7N@28216|Betaproteobacteria,476YR@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type IV Pilus-assembly protein W	pilW	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
k59_456976_1	1121447.JONL01000001_gene782	1.15e-19	96.3	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WKC0@28221|Deltaproteobacteria,2M7TX@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K10819	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HisKA,PAS_8,PAS_9,sCache_3_2
k59_540977_1	323848.Nmul_A1007	2.36e-111	332.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,371ZY@32003|Nitrosomonadales	28216|Betaproteobacteria	HL	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,TMP-TENI
k59_456978_1	882378.RBRH_01983	7.08e-40	146.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VMKT@28216|Betaproteobacteria,1KGW2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_913037_1	1396418.BATQ01000055_gene268	3.25e-130	395.0	COG0466@1|root,COG0466@2|Bacteria,46WWR@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Found in ATP-dependent protease La (LON)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1028694_1	933262.AXAM01000051_gene2985	9.4e-65	202.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,2MJQ6@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2496	GATase
k59_1028694_2	96561.Dole_1569	9.08e-32	122.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MI03@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_913046_1	523794.Lebu_0311	4.77e-10	65.5	COG1538@1|root,COG1538@2|Bacteria,378ET@32066|Fusobacteria	32066|Fusobacteria	MU	outer membrane efflux protein	-	-	-	ko:K03287	-	-	-	-	ko00000	1.B.17	-	-	OEP
k59_779655_1	160492.XF_0685	1.34e-18	85.5	28J2E@1|root,2Z8YX@2|Bacteria,1REPW@1224|Proteobacteria,1S4IX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2815)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2815
k59_283608_1	525909.Afer_1770	9.62e-55	187.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CMR3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_783492_1	391626.OAN307_c22420	1.47e-26	116.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_545177_1	748247.AZKH_p0058	7.64e-63	205.0	COG1143@1|root,COG1145@1|root,COG1143@2|Bacteria,COG1145@2|Bacteria,1QVIN@1224|Proteobacteria,2VI64@28216|Betaproteobacteria,2KVVD@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
k59_489061_1	395019.Bmul_2689	1.04e-65	216.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VHQI@28216|Betaproteobacteria,1K30N@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_285821_1	748247.AZKH_2063	5.61e-54	179.0	COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,2VQW2@28216|Betaproteobacteria,2KWKU@206389|Rhodocyclales	206389|Rhodocyclales	S	secreted protein	-	-	-	-	-	-	-	-	-	-	-	-	SIMPL
k59_783541_1	1236542.BALM01000008_gene2944	1.99e-10	61.2	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,2Q8Y2@267890|Shewanellaceae	1236|Gammaproteobacteria	E	TIGRFAM amino acid carrier protein	dagA	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_285826_1	330214.NIDE3699	4.22e-72	229.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Methyltransf_31,Radical_SAM
k59_545207_1	194867.ALBQ01000035_gene1075	7.89e-11	66.6	COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria,1NS4Q@1224|Proteobacteria,2U3BH@28211|Alphaproteobacteria,2KEH2@204457|Sphingomonadales	204457|Sphingomonadales	P	Secretin and TonB N terminus short domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_783544_1	1038867.AXAY01000001_gene6323	0.000322	42.4	COG0451@1|root,COG0451@2|Bacteria,1MWVE@1224|Proteobacteria,2TS8F@28211|Alphaproteobacteria,3JU8F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	MA20_16995	-	1.1.1.203	ko:K18981	ko00053,map00053	-	R10841	RC00066	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_783544_2	1504672.669786681	8.82e-92	281.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,4A9UW@80864|Comamonadaceae	28216|Betaproteobacteria	G	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_797771_1	323848.Nmul_A0732	5.5e-16	77.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,371YT@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	fbpA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
k59_797771_2	1120999.JONM01000009_gene415	6.95e-28	105.0	COG4378@1|root,COG4378@2|Bacteria,1N5HE@1224|Proteobacteria,2VVFP@28216|Betaproteobacteria,2KRF1@206351|Neisseriales	206351|Neisseriales	S	Uncharacterized protein conserved in bacteria (DUF2325)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2325
k59_797771_3	1033802.SSPSH_002479	1.13e-07	49.3	COG2906@1|root,COG2906@2|Bacteria	2|Bacteria	P	2 iron, 2 sulfur cluster binding	bfd	-	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
k59_797780_1	935548.KI912159_gene3045	3.31e-11	68.9	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,DZR,Guanylate_cyc,TPR_12
k59_1030896_1	1430331.EP10_02990	2.41e-14	73.2	COG3335@1|root,COG3335@2|Bacteria,1V41H@1239|Firmicutes,4HH52@91061|Bacilli,1WEBA@129337|Geobacillus	91061|Bacilli	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_285859_1	990285.RGCCGE502_09765	3.39e-05	51.6	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,4BA21@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
k59_797802_2	1459636.NTE_01603	2.91e-38	142.0	COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota	651137|Thaumarchaeota	J	histidyl-tRNA synthetase	-	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_545251_1	744980.TRICHSKD4_0977	2.08e-68	214.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type polar amino acid transport system ATPase component	glnQ	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
k59_797807_1	436308.Nmar_0016	1.44e-10	57.0	arCOG10511@1|root,arCOG10511@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_797807_2	304371.MCP_0299	5.65e-22	94.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_285868_1	713586.KB900536_gene936	5.09e-10	59.3	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1S1NC@1236|Gammaproteobacteria,1X06R@135613|Chromatiales	135613|Chromatiales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_285868_2	748247.AZKH_p0049	5.53e-81	257.0	COG4191@1|root,COG4191@2|Bacteria,1QVHZ@1224|Proteobacteria,2VJ34@28216|Betaproteobacteria,2KVSJ@206389|Rhodocyclales	206389|Rhodocyclales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_489164_2	1288494.EBAPG3_15710	3.91e-150	424.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,372KC@32003|Nitrosomonadales	28216|Betaproteobacteria	C	succinate dehydrogenase fumarate reductase	sdhB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17,Fer4_8
k59_489164_3	395494.Galf_1335	1.15e-18	80.9	COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,2VY7W@28216|Betaproteobacteria,44W4H@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
k59_489164_4	261292.Nit79A3_0847	1.23e-15	76.3	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,372Q1@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_545278_1	1158292.JPOE01000002_gene1854	6.44e-81	264.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_489176_1	857087.Metme_0149	2.44e-35	127.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,1XEWA@135618|Methylococcales	135618|Methylococcales	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA
k59_489176_2	323848.Nmul_A2455	1.75e-28	110.0	COG3087@1|root,COG3087@2|Bacteria,1RIU5@1224|Proteobacteria,2VTKT@28216|Betaproteobacteria,3731K@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_285906_1	105559.Nwat_2283	6.22e-77	243.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1WXJN@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_489192_1	1266925.JHVX01000013_gene1674	6.11e-100	296.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,372RB@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_489192_2	335283.Neut_0237	5.54e-08	53.1	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,372RN@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Phosphate transport system permease protein	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_545314_1	1502852.FG94_00862	3.03e-108	337.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,4769B@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
k59_285930_1	95619.PM1_0215970	3.12e-46	155.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	serine acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0840	Hexapep,SATase_N
k59_285930_2	1173023.KE650771_gene4245	6.28e-06	49.7	COG0565@1|root,COG0565@2|Bacteria,1G18I@1117|Cyanobacteria,1JHDI@1189|Stigonemataceae	1117|Cyanobacteria	J	SpoU rRNA Methylase family	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_824061_1	402777.KB235904_gene4117	3.25e-66	217.0	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1H97S@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_693491_1	1333998.M2A_2787	6.55e-89	271.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,4BSZR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_397965_1	330214.NIDE3313	1.73e-94	308.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
k59_7746_1	1245471.PCA10_40580	8.72e-48	178.0	COG2931@1|root,COG3209@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria,1MU7T@1224|Proteobacteria,1RZD3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind
k59_431635_3	1265502.KB905936_gene2640	6.91e-18	81.6	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,4AADA@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_138289_1	153948.NAL212_2298	2e-15	73.9	COG0454@1|root,COG0456@2|Bacteria,1RJDS@1224|Proteobacteria,2WC4A@28216|Betaproteobacteria,3746W@32003|Nitrosomonadales	28216|Betaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_138289_2	1163617.SCD_n00308	3.3e-37	138.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Lipid A Biosynthesis	htrB	-	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_986598_1	672.VV93_v1c00040	1.88e-79	259.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1XV37@135623|Vibrionales	135623|Vibrionales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009330,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0032991,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_105570_1	247490.KSU1_C1051	4.45e-07	57.0	COG3419@1|root,COG3419@2|Bacteria	2|Bacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	CarboxypepD_reg,Neisseria_PilC
k59_366383_1	1380391.JIAS01000014_gene2324	1.01e-83	262.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,2JPN0@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_138293_1	1408416.JNJT01000009_gene1308	2.2e-14	69.3	COG0103@1|root,COG0103@2|Bacteria,3WTKX@544448|Tenericutes	544448|Tenericutes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_138293_2	485915.Dret_0735	1.23e-40	138.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,42SD5@68525|delta/epsilon subdivisions,2WP5M@28221|Deltaproteobacteria,2MBR8@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_463103_1	234267.Acid_6928	1.16e-06	48.1	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_463103_2	452637.Oter_4509	3.4e-57	188.0	COG0409@1|root,COG0409@2|Bacteria,46U5J@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_693512_2	323848.Nmul_A2456	3.7e-125	374.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,371R0@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_105587_1	330214.NIDE0235	1.96e-25	98.2	COG0377@1|root,COG0377@2|Bacteria,3J11S@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_105587_2	330214.NIDE0236	1.83e-71	216.0	COG0838@1|root,COG0838@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_170904_1	96561.Dole_0795	7.26e-13	67.4	COG0517@1|root,COG0517@2|Bacteria,1RKZ2@1224|Proteobacteria,42SYQ@68525|delta/epsilon subdivisions,2WP9E@28221|Deltaproteobacteria,2MK65@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_170904_2	706587.Desti_4442	5.81e-24	94.4	COG2204@1|root,COG2204@2|Bacteria,1QWPT@1224|Proteobacteria,43BUK@68525|delta/epsilon subdivisions,2X75P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_954481_1	640081.Dsui_1455	2.76e-52	183.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	-	-	-	-	-	-	-	-	-	GAF,T2SSE,T2SSE_N
k59_954481_2	640081.Dsui_1452	1.24e-122	374.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,2KVW3@206389|Rhodocyclales	206389|Rhodocyclales	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_888452_1	864051.BurJ1DRAFT_1346	1.13e-74	236.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,1KJXY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_203388_1	1131462.DCF50_p945	1.67e-75	239.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,263T5@186807|Peptococcaceae	186801|Clostridia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_497640_1	323097.Nham_3328	1.91e-38	148.0	COG5301@1|root,COG5301@2|Bacteria,1N6XX@1224|Proteobacteria,2USJX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	cellulose 1,4-beta-cellobiosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_562862_1	1116472.MGMO_44c00100	1.95e-37	134.0	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,1XDVF@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_562862_2	870187.Thini_2729	1.05e-16	77.0	arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,460KA@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_138325_1	365046.Rta_02340	4.78e-65	212.0	COG3181@1|root,COG3181@2|Bacteria,1R4JE@1224|Proteobacteria,2VJTF@28216|Betaproteobacteria,4ABE5@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_398003_1	1384049.CD29_03190	1.08e-06	55.8	COG0715@1|root,COG0715@2|Bacteria,1TRT8@1239|Firmicutes,4IE5J@91061|Bacilli,3IZYU@400634|Lysinibacillus	91061|Bacilli	P	ABC transporter substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
k59_986628_1	391735.Veis_4532	1.04e-179	514.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VJ5H@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_40259_1	1485544.JQKP01000012_gene2149	3.14e-83	253.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,44UZK@713636|Nitrosomonadales	28216|Betaproteobacteria	H	PFAM UBA THIF-type NAD FAD binding protein	thiF	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_922038_1	886293.Sinac_3059	7.28e-30	116.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11,3.1.4.17	ko:K00784,ko:K01120	ko00230,ko03013,map00230,map03013	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000,ko03016	-	-	-	GAF,HD_5,Lactamase_B_2,PDEase_II
k59_562876_1	375286.mma_2567	6.09e-113	338.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,472Q2@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Transposase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_170934_1	316055.RPE_3216	2.61e-121	362.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,3JRW4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_234755_2	1242864.D187_001597	1.1e-50	167.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2YWYX@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_497667_1	261292.Nit79A3_3447	6.05e-12	66.6	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,37222@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_497667_2	882378.RBRH_02010	5.19e-94	285.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2VIQX@28216|Betaproteobacteria,1K1XK@119060|Burkholderiaceae	28216|Betaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
k59_366436_1	575586.HMPREF0016_02719	1.43e-91	277.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,1RMBA@1236|Gammaproteobacteria,3NITP@468|Moraxellaceae	1236|Gammaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_2698	Meth_synt_2
k59_74165_1	1430440.MGMSRv2_1474	3.45e-39	136.0	COG2905@1|root,COG2905@2|Bacteria,1N7MU@1224|Proteobacteria,2UGVF@28211|Alphaproteobacteria,2JYZN@204441|Rhodospirillales	204441|Rhodospirillales	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_74165_2	1040989.AWZU01000011_gene4010	2.43e-52	167.0	2CGAW@1|root,344FT@2|Bacteria,1RGC6@1224|Proteobacteria,2U873@28211|Alphaproteobacteria,3JZ52@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_74165_3	1500306.JQLA01000017_gene4880	4.91e-06	49.3	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria,4B9UJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_727006_1	1123073.KB899242_gene1206	3.27e-100	308.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1X3PI@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_825095_1	1005994.GTGU_03224	1.98e-70	233.0	COG2194@1|root,COG2194@2|Bacteria,1MWJY@1224|Proteobacteria,1RN4T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cellulose synthase operon protein YhjU	bcsG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBP_BcsG
k59_171839_1	1713.JOFV01000008_gene3234	5.39e-26	110.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4F0HR@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM CBS domain containing protein	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_235565_1	987059.RBXJA2T_10831	2.07e-99	306.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VIVH@28216|Betaproteobacteria,1KJKC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Creatinase/Prolidase N-terminal domain	pepQ	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
k59_432602_1	999541.bgla_1g31080	4.76e-86	274.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2VJ8C@28216|Betaproteobacteria,1K27R@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_139282_1	572477.Alvin_2726	3.7e-59	197.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_74172_1	167548.EU98_1828	6.54e-05	48.1	COG0535@1|root,COG0535@2|Bacteria,1GAF4@1117|Cyanobacteria	1117|Cyanobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
k59_74172_2	196367.JNFG01000202_gene2562	9.4e-33	120.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VQAE@28216|Betaproteobacteria,1KH7X@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_74172_3	1042326.AZNV01000013_gene3429	2.05e-17	80.5	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,4BFI1@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_786280_1	1121405.dsmv_0342	5.45e-133	390.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MIJV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_955491_1	1382315.JPOI01000001_gene2729	9.09e-05	44.7	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4HABJ@91061|Bacilli,1WGD0@129337|Geobacillus	91061|Bacilli	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_955491_2	1345697.M493_07600	3.73e-14	75.5	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,4HAE3@91061|Bacilli,1WF4B@129337|Geobacillus	91061|Bacilli	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_398856_1	105559.Nwat_1651	1.52e-26	107.0	COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria,1SYTE@1236|Gammaproteobacteria,1X0JZ@135613|Chromatiales	135613|Chromatiales	U	beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_367391_1	930166.CD58_23140	1.2e-27	110.0	COG0748@1|root,COG0748@2|Bacteria,1RFVC@1224|Proteobacteria,1S3AV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Heme iron utilization protein	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Putative_PNPOx,Pyrid_oxidase_2
k59_367391_2	395494.Galf_0533	7.88e-10	58.2	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2W9RT@28216|Betaproteobacteria,44W4A@713636|Nitrosomonadales	28216|Betaproteobacteria	S	NADPH-dependent FMN reductase	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
k59_171850_1	671143.DAMO_2624	9.01e-121	371.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_269762_1	273075.Ta1475	3e-21	98.2	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,241MT@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_8823_1	1189619.pgond44_14073	2e-37	148.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,TPR_12,TPR_7
k59_301818_1	1500259.JQLD01000012_gene5285	2.62e-35	138.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,4B8TI@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_987579_1	1454004.AW11_02488	1.84e-46	163.0	COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	1.20.4.1,3.1.3.48	ko:K01104,ko:K02039,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	PhoU
k59_661872_2	82654.Pse7367_3014	3.48e-109	319.0	COG1442@1|root,COG1442@2|Bacteria,1G3Z0@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase, family 8	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
k59_8826_1	381666.H16_B1609	7.6e-61	212.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,1K2BP@119060|Burkholderiaceae	28216|Betaproteobacteria	MV	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_8826_2	1005048.CFU_1851	4.71e-37	132.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,2VIQD@28216|Betaproteobacteria,4735R@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_694583_1	78579.XP_003661437.1	1.62e-06	55.1	COG1304@1|root,COG5274@1|root,KOG0537@2759|Eukaryota,KOG0538@2759|Eukaryota,38FH7@33154|Opisthokonta,3NUFP@4751|Fungi,3QP72@4890|Ascomycota,2154C@147550|Sordariomycetes,3U635@5139|Sordariales,3HFP2@35718|Chaetomiaceae	4751|Fungi	C	FMN-dependent dehydrogenase	-	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	Cyt-b5,DUF4202,FMN_dh
k59_334994_1	374847.Kcr_0725	4.95e-82	254.0	COG0123@1|root,arCOG00324@2157|Archaea	2157|Archaea	BQ	including yeast histone deacetylase and acetoin utilization protein	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_41205_1	84531.JMTZ01000024_gene4056	2.66e-16	77.4	COG2732@1|root,COG2732@2|Bacteria,1RD25@1224|Proteobacteria,1STYV@1236|Gammaproteobacteria,1X7KW@135614|Xanthomonadales	135614|Xanthomonadales	K	(barnase) inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	Barstar
k59_41205_2	1038869.AXAN01000013_gene6335	3.59e-21	87.8	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,1K6ZD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	ntpA	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
k59_367410_1	1163617.SCD_n00953	4.09e-49	162.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,2VRU5@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_367410_2	1163617.SCD_n00952	1.76e-19	87.4	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_106626_1	748247.AZKH_3524	3.3e-54	189.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KV42@206389|Rhodocyclales	206389|Rhodocyclales	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_41208_1	1303518.CCALI_00340	2.79e-09	63.2	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
k59_727053_1	706587.Desti_3013	8.36e-85	265.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N9U@68525|delta/epsilon subdivisions,2WINY@28221|Deltaproteobacteria	1224|Proteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_204359_1	566466.NOR53_2029	5.16e-38	137.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S4VY@1236|Gammaproteobacteria,1JAMV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_628824_1	448385.sce0887	1.9e-68	219.0	COG0673@1|root,COG0673@2|Bacteria,1R8B2@1224|Proteobacteria,4374E@68525|delta/epsilon subdivisions,2X1Z0@28221|Deltaproteobacteria,2YUQT@29|Myxococcales	28221|Deltaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_563860_1	1095769.CAHF01000022_gene145	3e-129	383.0	COG1538@1|root,COG1538@2|Bacteria,1MWB0@1224|Proteobacteria,2VIIW@28216|Betaproteobacteria,473BE@75682|Oxalobacteraceae	28216|Betaproteobacteria	MU	Outer membrane efflux protein	copB	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_596322_1	765911.Thivi_3494	8.41e-112	347.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_628836_1	640081.Dsui_0131	2.41e-122	366.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,2KV5X@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_171893_2	292415.Tbd_0111	1.31e-69	220.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,1KS80@119069|Hydrogenophilales	119069|Hydrogenophilales	M	MraW methylase family	-	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_987617_1	330214.NIDE0681	3.63e-84	262.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_694625_1	1120999.JONM01000001_gene1322	1.89e-06	50.1	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,2KQ6Y@206351|Neisseriales	206351|Neisseriales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_498711_1	1268068.PG5_13940	3.57e-79	248.0	COG1459@1|root,COG1459@2|Bacteria,1N8FA@1224|Proteobacteria,1RXYV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	type II secretion system protein	gspF	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_834771_1	686340.Metal_2049	1.21e-65	201.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1XFE6@135618|Methylococcales	135618|Methylococcales	L	PFAM Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_310352_1	566466.NOR53_1787	3.17e-50	179.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J99K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_2673	ACT_4,HD_4,RelA_SpoT,TGS
k59_605535_1	402626.Rpic_3111	1.15e-24	105.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,1K4GD@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Amino acid amide ABC transporter substrate-binding protein, HAAT family	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_789676_1	522306.CAP2UW1_2505	7.07e-92	280.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,1KQMF@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16,2.8.3.22	ko:K07749,ko:K14471,ko:K14472	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R00406,R03154	RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_471739_1	330214.NIDE2045	3.1e-97	290.0	COG0135@1|root,COG0135@2|Bacteria,3J0SA@40117|Nitrospirae	40117|Nitrospirae	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_508020_1	1183438.GKIL_1779	5.82e-46	166.0	COG2272@1|root,COG3187@1|root,COG2272@2|Bacteria,COG3187@2|Bacteria,1GA7U@1117|Cyanobacteria	1117|Cyanobacteria	O	META domain	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	META
k59_508020_2	1229172.JQFA01000002_gene3705	7.89e-29	108.0	2DZFE@1|root,32V9B@2|Bacteria,1G8M5@1117|Cyanobacteria,1HFZA@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_508020_3	159087.Daro_4183	5.13e-24	98.2	COG3971@1|root,COG3971@2|Bacteria,1R3UP@1224|Proteobacteria,2VNA2@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	hydratase decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_866263_1	267608.RSc3440	1.94e-55	195.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,1K194@119060|Burkholderiaceae	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_965142_2	1267005.KB911264_gene3170	8.37e-100	295.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2TSFD@28211|Alphaproteobacteria,3N6HU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	putrescine	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
k59_310366_1	478741.JAFS01000002_gene87	3.19e-98	293.0	COG3677@1|root,COG3677@2|Bacteria	2|Bacteria	L	transposition, DNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_573323_1	1384056.N787_10920	6.04e-14	69.7	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1X4ID@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_573323_2	1123354.AUDR01000013_gene711	1.62e-49	162.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria,1KRNS@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_834794_1	228410.NE1762	1.28e-85	271.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,372VA@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_148661_1	1349820.M707_02315	1.24e-06	51.6	COG1749@1|root,COG1749@2|Bacteria,2I2X3@201174|Actinobacteria	201174|Actinobacteria	N	Domain of unknown function (DUF4082)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,Mo-co_dimer,fn3
k59_148661_2	105559.Nwat_0850	0.000597	44.7	COG1873@1|root,COG1873@2|Bacteria,1QW30@1224|Proteobacteria	1224|Proteobacteria	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_FGFR
k59_181131_1	883.DvMF_2683	5.62e-11	68.2	COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
k59_311478_2	1131553.JIBI01000003_gene1738	2.12e-14	72.8	COG1216@1|root,COG1216@2|Bacteria,1N5DV@1224|Proteobacteria,2WB4B@28216|Betaproteobacteria,372A6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1021243_1	1218084.BBJK01000007_gene914	2.47e-83	269.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,1K1D1@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_672652_2	330214.NIDE3934	9.26e-64	204.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
k59_933739_1	1173022.Cri9333_3469	2.34e-101	313.0	COG1506@1|root,COG1506@2|Bacteria,1G200@1117|Cyanobacteria,1H8T3@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase family	dap2	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_867432_1	1005048.CFU_4002	5.46e-67	220.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,47309@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	dppA2	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_672655_1	1265313.HRUBRA_02087	1.15e-31	121.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1J4J5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_672655_2	1202962.KB907175_gene48	2.92e-19	84.7	28H8Z@1|root,2Z7KS@2|Bacteria,1MW9T@1224|Proteobacteria,1RQV1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1282
k59_836014_1	880073.Calab_0529	6.52e-53	189.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,2NRCG@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M28	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	iAF987.Gmet_0348	Cofac_haem_bdg,PA,PDZ_2,Peptidase_M1,Peptidase_M28,Trypsin_2
k59_639091_1	1125863.JAFN01000001_gene1223	2.74e-15	74.7	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2WK64@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EQ	PFAM Hydantoinase oxoprolinase	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_639091_2	1125863.JAFN01000001_gene1222	9.05e-121	360.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,43CGH@68525|delta/epsilon subdivisions,2WJ3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EQ	PFAM Hydantoinase B oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_472762_2	1000565.METUNv1_02476	3.24e-76	235.0	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,2KW6F@206389|Rhodocyclales	206389|Rhodocyclales	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_472762_3	1454004.AW11_00782	1.22e-11	64.7	2E95F@1|root,333E6@2|Bacteria,1N8N7@1224|Proteobacteria,2VWBC@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3619)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3619
k59_182304_1	478801.Ksed_05070	1.41e-17	87.8	COG1808@1|root,COG1808@2|Bacteria,2I0VT@201174|Actinobacteria,1ZX0C@145357|Dermacoccaceae	201174|Actinobacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_933749_1	1146883.BLASA_4391	3.39e-68	223.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4ERFK@85013|Frankiales	201174|Actinobacteria	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_407656_1	395495.Lcho_0055	6.21e-27	114.0	COG3850@1|root,COG3850@2|Bacteria,1QW6N@1224|Proteobacteria	1224|Proteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	2.7.13.3,4.6.1.1	ko:K01768,ko:K07678	ko00230,ko02020,ko02025,ko02026,ko04113,ko04213,ko05111,map00230,map02020,map02025,map02026,map04113,map04213,map05111	M00475,M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2222,GAF_2,Guanylate_cyc,HAMP,dCache_1
k59_606744_1	261292.Nit79A3_1075	7.69e-197	553.0	COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_117181_1	1131553.JIBI01000017_gene589	7.76e-40	149.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,371MP@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
k59_705506_1	99598.Cal7507_4702	1.17e-100	321.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1HJRQ@1161|Nostocales	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_533549_1	1304883.KI912532_gene656	2.32e-147	424.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,2KVER@206389|Rhodocyclales	206389|Rhodocyclales	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metX	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_899212_1	497321.C664_18594	1e-104	312.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,2KV7G@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_407665_1	1174684.EBMC1_00600	9.51e-53	187.0	COG4773@1|root,COG4773@2|Bacteria,1QURT@1224|Proteobacteria,2TW53@28211|Alphaproteobacteria,2K0HG@204457|Sphingomonadales	204457|Sphingomonadales	P	receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_606754_1	1459636.NTE_01556	5.97e-30	115.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_275946_1	313628.LNTAR_06999	1.92e-92	284.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve,rve_3
k59_214630_1	671143.DAMO_2848	7.25e-111	333.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2NNX4@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027	CBS,IMPDH,NMO
k59_51582_1	383372.Rcas_1885	1.28e-39	142.0	COG1085@1|root,COG1085@2|Bacteria,2G6K5@200795|Chloroflexi,3759B@32061|Chloroflexia	32061|Chloroflexia	H	PFAM galactose-1-phosphate uridyl transferase domain protein	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
k59_51582_2	1445613.JALM01000019_gene5763	1.16e-16	81.6	COG0153@1|root,COG0153@2|Bacteria,2GJXI@201174|Actinobacteria,4E015@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
k59_672685_1	1121028.ARQE01000016_gene2619	2.18e-86	262.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2PK0U@255475|Aurantimonadaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_182316_1	323848.Nmul_A1770	3.28e-245	689.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,372H8@32003|Nitrosomonadales	28216|Betaproteobacteria	T	protein synthesis factor, GTP-binding	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_182316_2	1382304.JNIL01000001_gene1507	4.17e-17	81.3	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,4HJ3P@91061|Bacilli	91061|Bacilli	C	COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs	pucC	-	1.17.1.4,1.2.5.3	ko:K00087,ko:K03519	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_345449_1	985867.AEWF01000003_gene785	1.3e-108	321.0	COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,2TRVQ@28211|Alphaproteobacteria,47FVE@766|Rickettsiales	766|Rickettsiales	O	Aspartyl/Asparaginyl beta-hydroxylase	-	-	-	ko:K12979	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Asp_Arg_Hydrox
k59_117194_1	232721.Ajs_3546	2.41e-51	175.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_836048_1	1229909.NSED_01530	1.88e-26	105.0	COG0148@1|root,arCOG01169@2157|Archaea,41SE9@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_311523_1	626418.bglu_1g14470	2.25e-53	170.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2VQ2J@28216|Betaproteobacteria,1K70Q@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_311523_2	1100720.ALKN01000045_gene439	8.2e-33	120.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VKXH@28216|Betaproteobacteria,4ACGJ@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	tauD	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_867481_1	1123261.AXDW01000008_gene891	4.31e-71	218.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,1S24N@1236|Gammaproteobacteria,1X6RD@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
k59_19536_1	240016.ABIZ01000001_gene3117	1.64e-121	356.0	COG1131@1|root,COG1131@2|Bacteria,46UCI@74201|Verrucomicrobia,2IU5T@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_836077_1	1123242.JH636434_gene3841	3.12e-71	222.0	COG1484@1|root,COG1484@2|Bacteria,2J3U3@203682|Planctomycetes	203682|Planctomycetes	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_19537_1	1499967.BAYZ01000188_gene3895	2.18e-21	94.4	COG0624@1|root,COG0624@2|Bacteria,2NNX2@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_19537_2	511051.CSE_03770	7.49e-55	185.0	COG0031@1|root,COG0031@2|Bacteria	2|Bacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47,6.2.1.30	ko:K01738,ko:K01912	ko00270,ko00360,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko05111,map00270,map00360,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map05111	M00021	R00897,R02539,R03601,R04859	RC00004,RC00014,RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_275964_1	994573.T472_0212695	8e-17	79.7	COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,247UD@186801|Clostridia,36EHK@31979|Clostridiaceae	186801|Clostridia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
k59_275964_2	555779.Dthio_PD3362	1.38e-41	145.0	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,42R9G@68525|delta/epsilon subdivisions,2WMTN@28221|Deltaproteobacteria,2MF17@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
k59_149913_1	1157708.KB907478_gene1212	2.76e-47	162.0	COG0596@1|root,COG0596@2|Bacteria,1NJ2B@1224|Proteobacteria,2W052@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_345478_1	945713.IALB_3136	3.88e-90	268.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	VPA0557	-	-	-	-	-	-	-	-	-	-	-	DUF4292,LolA_like
k59_345478_2	945713.IALB_3135	2.22e-36	133.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	VPA0558	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1021276_1	1265505.ATUG01000001_gene4657	1.32e-35	132.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2MI9P@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_966415_1	864051.BurJ1DRAFT_0069	8.07e-33	130.0	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,2VIWE@28216|Betaproteobacteria,1KJXJ@119065|unclassified Burkholderiales	1224|Proteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_4
k59_377507_1	1268622.AVS7_01556	2.19e-15	81.3	2DPR1@1|root,3331B@2|Bacteria,1NA5C@1224|Proteobacteria,2WG02@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_377507_3	652103.Rpdx1_2082	8.14e-40	150.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria,3JRPY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	-	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0044464,GO:0046903,GO:0051179,GO:0051234,GO:0071944	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_472821_2	1485544.JQKP01000005_gene320	1.57e-08	57.8	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,44V9S@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_21,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_766763_1	1158762.KB898052_gene271	3.7e-81	252.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1WWZ4@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_766763_2	106648.BBLJ01000010_gene835	6.02e-05	45.1	COG2267@1|root,COG2267@2|Bacteria,1QQRE@1224|Proteobacteria,1SHYW@1236|Gammaproteobacteria,3NJZW@468|Moraxellaceae	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_966416_2	1397528.Q671_10735	1.2e-09	67.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1XI78@135619|Oceanospirillales	135619|Oceanospirillales	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_639168_1	1400524.KL370779_gene259	2.66e-08	55.5	COG0071@1|root,COG0071@2|Bacteria,1R9Y1@1224|Proteobacteria,2UA1J@28211|Alphaproteobacteria,4BQNT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspH	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
k59_442807_1	631454.N177_0823	1.53e-71	229.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,1JPPV@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_774303_1	1123368.AUIS01000012_gene760	1.2e-23	95.1	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,2NC7F@225057|Acidithiobacillales	225057|Acidithiobacillales	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_583427_1	68194.JNXR01000007_gene4017	2.13e-06	54.3	COG3208@1|root,COG3208@2|Bacteria,2I0WZ@201174|Actinobacteria	201174|Actinobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
k59_518046_1	1304883.KI912532_gene3012	5.57e-106	337.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KXVB@206389|Rhodocyclales	206389|Rhodocyclales	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_9,dCache_1
k59_385423_1	765912.Thimo_3613	1.98e-09	57.8	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S60F@1236|Gammaproteobacteria,1WY72@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM clan AA aspartic protease, TIGR02281 family	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_774306_1	335283.Neut_0384	1.83e-126	393.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,3727S@32003|Nitrosomonadales	28216|Betaproteobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1006123_1	1000565.METUNv1_02456	7.68e-100	311.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	-	-	-	-	-	-	-	-	-	GAF,T2SSE,T2SSE_N
k59_793942_2	439235.Dalk_1643	7.73e-49	166.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,2MI2C@213118|Desulfobacterales	28221|Deltaproteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_223684_1	388051.AUFE01000062_gene5245	4.3e-52	174.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VI9J@28216|Betaproteobacteria,1K591@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_715210_1	1125863.JAFN01000001_gene2545	1.8e-84	268.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_876735_1	582744.Msip34_0036	4.12e-106	322.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria,2KM4E@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_876735_2	1163617.SCD_n02800	2.11e-99	297.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	response regulator	algR	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_876735_3	395494.Galf_2511	2.78e-38	137.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,44V8C@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_648405_1	1121930.AQXG01000018_gene769	6.68e-29	120.0	COG5002@1|root,COG5002@2|Bacteria,4PKMH@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,HisKA_7TM,PAS_4,PAS_9,TPR_12
k59_775129_1	517433.PanABDRAFT_1298	6.69e-37	139.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,3VXTN@53335|Pantoea	1236|Gammaproteobacteria	IQ	Activates fatty acids by binding to coenzyme A	fadD	GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006644,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009898,GO:0009987,GO:0015645,GO:0016020,GO:0016042,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0030258,GO:0031406,GO:0032787,GO:0033293,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0036041,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046395,GO:0046483,GO:0050896,GO:0051186,GO:0055086,GO:0055114,GO:0070538,GO:0071704,GO:0071944,GO:0072329,GO:0072521,GO:0090407,GO:0098552,GO:0098562,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	iSF_1195.SF1423,iSFxv_1172.SFxv_1611,iS_1188.S1538	AMP-binding,AMP-binding_C
k59_775129_2	1216007.AOPM01000015_gene3199	2.35e-22	94.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,2Q03T@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Lipase_GDSL_2
k59_386255_2	1123242.JH636434_gene5438	9.72e-25	105.0	COG1523@1|root,COG1523@2|Bacteria,2IX65@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_319990_1	1144319.PMI16_02731	2.74e-55	179.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,472Y9@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_715214_1	342113.DM82_668	3.68e-08	60.5	COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,2VIP9@28216|Betaproteobacteria,1KFIC@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_60570_1	1163617.SCD_n01096	1.57e-34	130.0	COG4255@1|root,COG4255@2|Bacteria,1RA9X@1224|Proteobacteria,2WGEF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PhosphMutase
k59_191283_2	658086.HMPREF0994_01892	4.85e-27	110.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,27J2I@186928|unclassified Lachnospiraceae	186801|Clostridia	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_94628_1	439235.Dalk_3802	2.42e-50	167.0	COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,42PNV@68525|delta/epsilon subdivisions,2WJVJ@28221|Deltaproteobacteria,2MK8B@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_845904_1	977880.RALTA_B0067	7.91e-113	332.0	COG3181@1|root,COG3181@2|Bacteria,1MYJX@1224|Proteobacteria,2VKS4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_747720_1	278957.ABEA03000099_gene886	4.61e-52	176.0	COG3666@1|root,COG3666@2|Bacteria,46S8M@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1006961_2	338966.Ppro_3145	2.58e-57	188.0	COG1192@1|root,COG1192@2|Bacteria,1Q9JB@1224|Proteobacteria,43025@68525|delta/epsilon subdivisions,2WV6Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_775143_1	1459636.NTE_02739	1.64e-44	154.0	COG1741@1|root,arCOG02935@2157|Archaea	2157|Archaea	S	Belongs to the Pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_191296_1	338969.Rfer_3644	2.16e-54	180.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2VMHH@28216|Betaproteobacteria,4ADY8@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux,ZT_dimer
k59_775145_2	987059.RBXJA2T_16212	1.67e-44	150.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,1KM3J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Phosphotransferase system, mannose fructose-specific component IIA	manX	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	EIIA-man
k59_775145_3	1268622.AVS7_01562	0.000613	39.7	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,4AF0H@80864|Comamonadaceae	28216|Betaproteobacteria	G	TIGRFAM phosphocarrier, HPr family	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_252609_1	1243664.CAVL020000045_gene2105	1.35e-78	248.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HA40@91061|Bacilli,1ZMF3@1386|Bacillus	91061|Bacilli	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
k59_793952_1	1120956.JHZK01000029_gene90	6.86e-82	255.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,1JN64@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_126565_2	504487.JCM19302_3550	2.46e-16	77.4	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia	976|Bacteroidetes	Q	Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_518981_1	1122951.ATUE01000005_gene1908	6.97e-21	95.9	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,3NKN9@468|Moraxellaceae	1236|Gammaproteobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k59_94650_2	1270196.JCKI01000007_gene2377	3.42e-14	73.9	COG0166@1|root,COG0166@2|Bacteria,4NDV0@976|Bacteroidetes,1IPXI@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_584426_1	945713.IALB_2614	1.36e-44	153.0	COG0306@1|root,COG0306@2|Bacteria	2|Bacteria	P	phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_976260_1	1424334.W822_15655	1.26e-80	264.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,3T2E9@506|Alcaligenaceae	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_386301_1	330214.NIDE0264	4.34e-92	280.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_386302_1	1265505.ATUG01000003_gene158	4.56e-75	244.0	COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2MHN0@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphofructokinase	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_480806_1	1353531.AZNX01000024_gene4674	6.54e-79	248.0	COG2114@1|root,COG2146@1|root,COG2114@2|Bacteria,COG2146@2|Bacteria,1R110@1224|Proteobacteria	1224|Proteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_126594_1	159087.Daro_3364	2.94e-82	255.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,2KV9X@206389|Rhodocyclales	206389|Rhodocyclales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_682559_3	1207076.ALAT01000099_gene2354	5.69e-26	103.0	COG5446@1|root,COG5446@2|Bacteria,1RBWQ@1224|Proteobacteria,1S72H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cobalt transporter	cbtA	-	-	-	-	-	-	-	-	-	-	-	CbtA
k59_715280_1	1232410.KI421415_gene3014	5.92e-08	57.8	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,43S23@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Lytic transglycosylase catalytic	mltD2	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_320046_1	742159.HMPREF0004_2041	1.23e-16	82.8	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2VJ3T@28216|Betaproteobacteria,3T3SQ@506|Alcaligenaceae	28216|Betaproteobacteria	GM	NAD dependent epimerase dehydratase family protein	yeeZ	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind,TrkA_N
k59_1026076_1	1047013.AQSP01000074_gene1894	1.78e-93	287.0	COG0201@1|root,COG0201@2|Bacteria,2NNVK@2323|unclassified Bacteria	2|Bacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1026076_2	1051632.TPY_0344	1.87e-13	68.9	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,3WCG7@538999|Clostridiales incertae sedis	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
k59_1007008_1	338963.Pcar_1239	3.93e-103	312.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,43TT3@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_94681_1	497321.C664_06933	1.81e-219	621.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,2KVPJ@206389|Rhodocyclales	206389|Rhodocyclales	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_845962_1	886293.Sinac_4362	2.21e-65	211.0	COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes	203682|Planctomycetes	P	COG0798 Arsenite efflux pump ACR3 and related	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_845962_2	177437.HRM2_48270	4.97e-13	67.4	COG0526@1|root,COG0526@2|Bacteria,1N0R9@1224|Proteobacteria,42UD9@68525|delta/epsilon subdivisions,2WQ0H@28221|Deltaproteobacteria,2MK3U@213118|Desulfobacterales	28221|Deltaproteobacteria	CO	Thioredoxin	trx-2	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_715287_1	396588.Tgr7_2034	1.31e-99	310.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RYC8@1236|Gammaproteobacteria,1WX4W@135613|Chromatiales	135613|Chromatiales	G	Transketolase central region	-	-	-	-	-	-	-	-	-	-	-	-	XFP,XFP_N
k59_191346_2	1121035.AUCH01000008_gene1003	8.26e-33	122.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,2KWGK@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_252649_1	1123248.KB893337_gene2566	1.55e-26	100.0	COG5470@1|root,COG5470@2|Bacteria,4NUEC@976|Bacteroidetes,1IZ1F@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
k59_252649_2	1131269.AQVV01000001_gene1469	2.97e-32	130.0	COG0457@1|root,COG1262@1|root,COG0457@2|Bacteria,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
k59_29005_1	159087.Daro_0853	2.21e-63	206.0	COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,2KUYE@206389|Rhodocyclales	206389|Rhodocyclales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_908315_1	291985.CCSI01000002_gene1456	3.26e-21	94.4	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2UCDH@28211|Alphaproteobacteria,2KD3F@204457|Sphingomonadales	204457|Sphingomonadales	KT	LytTr DNA-binding domain	-	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_252656_1	272568.GDI0995	3.47e-82	252.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,2JPZ1@204441|Rhodospirillales	204441|Rhodospirillales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_775201_1	330214.NIDE0225	2.58e-108	326.0	COG1007@1|root,COG1007@2|Bacteria,3J0FN@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1026081_1	330214.NIDE3389	1.11e-102	307.0	COG3178@1|root,COG3178@2|Bacteria,3J15Y@40117|Nitrospirae	40117|Nitrospirae	S	Phosphotransferase enzyme family	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
k59_1007015_2	330214.NIDE1358	1.46e-122	367.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3J0EB@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_126623_1	1461693.ATO10_08788	6.08e-64	198.0	COG3793@1|root,COG3793@2|Bacteria,1RD1X@1224|Proteobacteria,2U788@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM Mo-dependent nitrogenase	-	-	-	-	-	-	-	-	-	-	-	-	TerB
k59_159270_1	62928.azo1058	2.04e-65	212.0	COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,2VJXB@28216|Betaproteobacteria,2KVPI@206389|Rhodocyclales	206389|Rhodocyclales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_60643_1	1411123.JQNH01000001_gene886	1.82e-175	513.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_538336_1	1229909.NSED_06860	1.27e-181	524.0	COG0464@1|root,arCOG01308@2157|Archaea,41S7X@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48) domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_648493_1	748247.AZKH_4435	1.65e-52	178.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,2KU7G@206389|Rhodocyclales	206389|Rhodocyclales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	rnfF	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_648493_2	153948.NAL212_2394	1.6e-28	111.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,37249@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_519040_1	436308.Nmar_0315	5.22e-39	139.0	COG1577@1|root,arCOG01028@2157|Archaea,41SKC@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_519040_2	1229909.NSED_01515	4.28e-88	264.0	COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Amino acid kinase family	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_519044_1	83406.HDN1F_07790	2.47e-28	117.0	COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,1J7E8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
k59_126632_1	864051.BurJ1DRAFT_2993	6.48e-88	285.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,1KIUR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_359495_2	483215.BACFIN_07745	8.8e-21	94.0	COG2385@1|root,COG2385@2|Bacteria,4NG21@976|Bacteroidetes,2FP4W@200643|Bacteroidia,4AM9T@815|Bacteroidaceae	976|Bacteroidetes	D	SpoIID LytB domain protein	lytB	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	DUF4922,Glycos_transf_2,SpoIID
k59_413_1	391615.ABSJ01000054_gene1377	6.05e-107	322.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1J8US@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_196317_2	522306.CAP2UW1_2582	6.73e-93	288.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	korC	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_417_1	936455.KI421499_gene4638	1.19e-17	88.2	COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,3JR5W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_8,PAS_9,Pkinase
k59_881906_1	754035.Mesau_04667	1.19e-45	161.0	COG1879@1|root,COG1879@2|Bacteria,1MV17@1224|Proteobacteria,2U8PP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
k59_196318_1	1100720.ALKN01000040_gene2251	9.07e-103	305.0	COG2267@1|root,COG2267@2|Bacteria,1MV7P@1224|Proteobacteria,2VPTY@28216|Betaproteobacteria,4AGS7@80864|Comamonadaceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_65723_1	391038.Bphy_3520	1.32e-95	298.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,1K4J9@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_816702_1	203124.Tery_1799	2.77e-06	52.0	COG0723@1|root,COG0723@2|Bacteria,1G03Q@1117|Cyanobacteria,1H9D7@1150|Oscillatoriales	1117|Cyanobacteria	C	Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions	petC	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	CytB6-F_Fe-S,Rieske
k59_294265_1	580332.Slit_1271	8.64e-79	246.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,44WDG@713636|Nitrosomonadales	28216|Betaproteobacteria	KLT	PFAM Serine threonine-protein kinase-like domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
k59_131001_1	945713.IALB_0288	5.32e-61	210.0	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	1.1.1.3,1.4.1.2,2.7.7.19,2.7.7.42,2.7.7.59,2.7.7.72,2.7.7.89	ko:K00003,ko:K00970,ko:K00974,ko:K00982,ko:K00990,ko:K06950,ko:K15371	ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,ko03013,ko03018,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020,map03013,map03018	M00017,M00018	R00243,R01773,R01775,R09382,R09383,R09384,R09386	RC00006,RC00078,RC00087,RC02799	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2,PolyA_pol,PolyA_pol_RNAbd
k59_294267_1	1121481.AUAS01000005_gene2105	3.41e-16	79.7	COG1236@1|root,COG1236@2|Bacteria,4NESD@976|Bacteroidetes,47K9F@768503|Cytophagia	976|Bacteroidetes	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
k59_294267_2	945713.IALB_3150	5.1e-37	132.0	COG0568@1|root,COG0568@2|Bacteria	2|Bacteria	K	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_686075_1	1144342.PMI40_01990	2.53e-11	61.2	COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,2VTXE@28216|Betaproteobacteria,474RW@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	CbiX	cbiX	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
k59_686075_2	159087.Daro_3140	7.53e-76	229.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2VQ5I@28216|Betaproteobacteria,2KWAF@206389|Rhodocyclales	206389|Rhodocyclales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_653481_1	1140001.I571_01958	2.46e-28	117.0	COG3979@1|root,COG4733@1|root,COG3979@2|Bacteria,COG4733@2|Bacteria,1UN16@1239|Firmicutes,4IU50@91061|Bacilli,4B0Z9@81852|Enterococcaceae	91061|Bacilli	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
k59_65744_1	1131553.JIBI01000001_gene1481	2.44e-76	235.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VH1Z@28216|Betaproteobacteria,3726Z@32003|Nitrosomonadales	28216|Betaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_1012382_2	1000565.METUNv1_01299	2.28e-85	261.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,2KU95@206389|Rhodocyclales	206389|Rhodocyclales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_1012430_1	1049564.TevJSym_ah00210	4.09e-45	149.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1J6UX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_1012430_2	1049564.TevJSym_ah00220	1.82e-20	84.3	COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
k59_522989_1	1454004.AW11_01544	6.86e-79	254.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2VMAN@28216|Betaproteobacteria	28216|Betaproteobacteria	CP	NADH ubiquinone plastoquinone (Complex I)	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_98516_1	666681.M301_0147	4.3e-12	67.4	2CG4C@1|root,2Z8MQ@2|Bacteria,1R6PQ@1224|Proteobacteria,2VHKG@28216|Betaproteobacteria,2KKMA@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_98516_2	1236959.BAMT01000006_gene247	3.48e-53	179.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria,2KKSQ@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_882049_1	290400.Jann_2941	9.73e-65	214.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TRM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_882049_2	1205680.CAKO01000010_gene3899	4.7e-87	262.0	COG0410@1|root,COG0410@2|Bacteria,1NKE2@1224|Proteobacteria,2U14V@28211|Alphaproteobacteria,2JVRU@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_327116_1	1121374.KB891575_gene1467	2.23e-30	118.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_490415_1	1122604.JONR01000010_gene3941	1.52e-90	276.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1X5US@135614|Xanthomonadales	135614|Xanthomonadales	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_882055_1	312153.Pnuc_0050	5.59e-162	474.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,1K1SJ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_294443_1	945713.IALB_1698	3.11e-52	176.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_294443_2	945713.IALB_1699	3.17e-44	150.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_620957_2	1366050.N234_14945	3.44e-111	330.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VHJZ@28216|Betaproteobacteria,1K1TX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the citrate synthase family	prpC	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
k59_327122_1	1279009.ADICEAN_03633	2.21e-78	256.0	COG2132@1|root,COG2132@2|Bacteria,4NE3N@976|Bacteroidetes,47KSB@768503|Cytophagia	976|Bacteroidetes	Q	PFAM multicopper oxidase type 3	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_980076_1	945713.IALB_1644	1.77e-64	218.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_980076_2	945713.IALB_1643	2.67e-69	219.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_588343_1	977880.RALTA_B0573	2.12e-20	89.4	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1K42H@119060|Burkholderiaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	aldA	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_588343_2	595537.Varpa_3587	2.47e-37	136.0	COG0346@1|root,COG0346@2|Bacteria,1MVVU@1224|Proteobacteria,2VKDD@28216|Betaproteobacteria,4ABYA@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_914837_2	331869.BAL199_16353	8.6e-85	266.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,4BPZA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_686261_1	709797.CSIRO_0402	5.82e-44	151.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2TS5K@28211|Alphaproteobacteria,3JQRH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	MA20_05995	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
k59_686261_2	1380355.JNIJ01000061_gene619	6.53e-09	56.6	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,3JU9D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	AMP-binding enzyme C-terminal domain	MA20_04975	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_718869_1	1123073.KB899242_gene889	3.32e-22	92.8	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,1SFMR@1236|Gammaproteobacteria,1X7TA@135614|Xanthomonadales	135614|Xanthomonadales	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_718869_2	247633.GP2143_10682	1.09e-08	55.8	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1J54F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Catabolite gene activator and regulatory subunit of cAMP-dependent protein	anr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_196561_1	640081.Dsui_1455	1.36e-128	392.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	-	-	-	-	-	-	-	-	-	GAF,T2SSE,T2SSE_N
k59_849479_1	864051.BurJ1DRAFT_3225	1.99e-74	244.0	COG1600@1|root,COG1600@2|Bacteria,1QZV5@1224|Proteobacteria	1224|Proteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase
k59_849479_2	1476583.DEIPH_ctg036orf0007	7.73e-09	58.9	COG1087@1|root,COG1087@2|Bacteria,1WMCP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_914845_2	1260251.SPISAL_05855	6.28e-31	120.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_392383_1	521098.Aaci_0673	4.82e-08	59.7	COG1352@1|root,COG2201@1|root,COG4191@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG4191@2|Bacteria,1TPD8@1239|Firmicutes,4HAS1@91061|Bacilli	91061|Bacilli	NT	Chemotaxis protein CheR	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_3,PAS_9
k59_327155_1	1322246.BN4_12655	5e-88	276.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2MA96@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycosyl transferase, family 20	otsAB	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,S6PP,Trehalose_PPase
k59_816945_1	574087.Acear_1656	8.73e-55	187.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,3WAAC@53433|Halanaerobiales	186801|Clostridia	O	chelatase, subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_653705_2	580332.Slit_2620	3.5e-141	415.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2VMTN@28216|Betaproteobacteria,44V6E@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_816950_1	1120972.AUMH01000006_gene1897	1.37e-24	101.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	-	-	4.1.1.69,4.1.2.17	ko:K01628,ko:K18256	ko00051,ko00624,ko01120,map00051,map00624,map01120	M00636	R01634,R02262	RC00569,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II,UPF0066
k59_294489_1	1255043.TVNIR_0150	2.36e-51	167.0	COG0599@1|root,COG2146@1|root,COG0599@2|Bacteria,COG2146@2|Bacteria,1RCCG@1224|Proteobacteria	1224|Proteobacteria	P	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Rieske
k59_359744_1	526222.Desal_2779	6.97e-49	162.0	COG1853@1|root,COG1853@2|Bacteria,1RBSR@1224|Proteobacteria,42R0G@68525|delta/epsilon subdivisions,2WMYE@28221|Deltaproteobacteria,2MAM7@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_98589_1	1100721.ALKO01000008_gene2618	3.2e-06	48.9	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,4AA8X@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_196589_1	1101195.Meth11DRAFT_0769	2.28e-45	161.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,2KKYE@206350|Nitrosomonadales	206350|Nitrosomonadales	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_359747_1	292415.Tbd_2474	1.34e-69	224.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,2VK76@28216|Betaproteobacteria,1KSUI@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_751497_1	330214.NIDE4329	1.76e-88	276.0	COG0728@1|root,COG0728@2|Bacteria,3J0CQ@40117|Nitrospirae	40117|Nitrospirae	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_686293_1	1123229.AUBC01000013_gene2593	5.15e-40	143.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,3JSVJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_686293_2	639283.Snov_2984	2.53e-114	334.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2TSVI@28211|Alphaproteobacteria,3EY8D@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	PFAM Xylose isomerase domain protein TIM barrel	hyi	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
k59_882108_2	765910.MARPU_02505	5.72e-06	49.3	COG1801@1|root,COG1801@2|Bacteria,1MXIQ@1224|Proteobacteria,1RRGD@1236|Gammaproteobacteria,1X0KH@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_914879_1	439235.Dalk_3434	6.21e-172	506.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_163940_1	1265505.ATUG01000001_gene3026	4.73e-118	375.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_392412_1	1121104.AQXH01000001_gene1671	2.9e-06	55.5	COG1520@1|root,COG1572@1|root,COG2706@1|root,COG3391@1|root,COG5184@1|root,COG1520@2|Bacteria,COG1572@2|Bacteria,COG2706@2|Bacteria,COG3391@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	CHU_C,DUF11,DUF4347,VCBS
k59_555808_1	323848.Nmul_A1906	5.75e-106	320.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,3723J@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_196611_1	261292.Nit79A3_0235	2.32e-109	325.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,371PD@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_359774_2	641491.DND132_1348	1.74e-105	317.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2M81W@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_555828_1	330214.NIDE3553	4.73e-142	413.0	COG2256@1|root,COG2256@2|Bacteria,3J0H6@40117|Nitrospirae	40117|Nitrospirae	L	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
k59_523115_1	1168065.DOK_00592	3.36e-57	199.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1J4IY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretory pathway, component	pilQ	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	-	ko:K02507,ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_653757_2	1395571.TMS3_0116125	1.5e-75	255.0	COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_33363_1	443143.GM18_0377	9.25e-44	160.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y50@68525|delta/epsilon subdivisions,2WUBF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HTH_8,PAS_4,Sigma54_activat
k59_163979_1	203122.Sde_2632	1.66e-72	235.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria,4663Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 2 family	uidA	GO:0003674,GO:0003824,GO:0004553,GO:0004566,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016054,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0019389,GO:0019391,GO:0019752,GO:0022607,GO:0042802,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_490529_1	1288494.EBAPG3_26720	1.39e-101	310.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,372Q8@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_882140_1	1288494.EBAPG3_11570	3.35e-134	392.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,371NA@32003|Nitrosomonadales	28216|Betaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_751535_1	395495.Lcho_1925	3.35e-73	235.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,2VKVU@28216|Betaproteobacteria,1KK05@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_261949_1	1219045.BV98_000680	1.67e-82	266.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2K0EB@204457|Sphingomonadales	204457|Sphingomonadales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_499323_1	331678.Cphamn1_2223	1.29e-66	212.0	COG0040@1|root,COG0040@2|Bacteria,1FDU2@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_662542_1	1168289.AJKI01000031_gene928	3.19e-24	103.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia,3XKNN@558415|Marinilabiliaceae	976|Bacteroidetes	E	Formiminotransferase domain, N-terminal subdomain	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
k59_889953_1	945713.IALB_3051	1.72e-97	308.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2
k59_662543_1	265072.Mfla_0235	2.12e-30	123.0	COG0642@1|root,COG0642@2|Bacteria,1R49A@1224|Proteobacteria,2VKU5@28216|Betaproteobacteria,2KMC6@206350|Nitrosomonadales	206350|Nitrosomonadales	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_924908_1	1266925.JHVX01000005_gene1938	1.1e-19	86.7	COG3312@1|root,COG3312@2|Bacteria,1R3CS@1224|Proteobacteria,2WIGV@28216|Betaproteobacteria,374P5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_924908_2	1165096.ARWF01000001_gene1577	1.82e-39	139.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KKB3@206350|Nitrosomonadales	206350|Nitrosomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_271540_1	580332.Slit_0522	1.86e-13	73.2	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,44VUU@713636|Nitrosomonadales	28216|Betaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
k59_271540_2	1123392.AQWL01000005_gene2941	1.9e-45	152.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,1KSIZ@119069|Hydrogenophilales	119069|Hydrogenophilales	M	OmpA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
k59_529303_2	457398.HMPREF0326_01629	4.45e-12	67.4	COG0778@1|root,COG0778@2|Bacteria,1PDTZ@1224|Proteobacteria,42SQ3@68525|delta/epsilon subdivisions,2WPC5@28221|Deltaproteobacteria,2MB1K@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_141142_1	228410.NE0445	1.33e-178	507.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,372TZ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_141142_2	1123401.JHYQ01000016_gene2958	1.4e-06	52.8	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,4600P@72273|Thiotrichales	72273|Thiotrichales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_173772_1	316067.Geob_3043	1.47e-07	57.0	COG2239@1|root,COG2239@2|Bacteria,1RFCV@1224|Proteobacteria,42S1B@68525|delta/epsilon subdivisions,2WP0D@28221|Deltaproteobacteria,43VZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
k59_108504_1	688270.Celal_2939	2.21e-14	75.1	COG0642@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,4NG0Y@976|Bacteroidetes,1HXCZ@117743|Flavobacteriia	976|Bacteroidetes	T	Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9
k59_858942_1	221288.JH992901_gene1890	7.97e-25	107.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GD97@1117|Cyanobacteria	1117|Cyanobacteria	T	Serine Threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_35,GAF,GAF_2,HATPase_c,HisKA,HisKA_3,PAS_4,Pkinase
k59_369196_1	395495.Lcho_1343	8.28e-84	270.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,1KN24@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_271543_2	1109445.AGSX01000187_gene2398	1.17e-25	107.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1Z0MI@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	permease	perM	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_598179_1	945713.IALB_1910	3.65e-92	283.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_5,Acyl_transf_3,DUF1624
k59_108506_1	62928.azo1702	5.25e-75	242.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,2KUFZ@206389|Rhodocyclales	206389|Rhodocyclales	C	COG1960 Acyl-CoA dehydrogenases	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_630640_1	296591.Bpro_2485	8.37e-85	265.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_434422_1	1100720.ALKN01000035_gene868	9.81e-08	52.4	COG3473@1|root,COG3473@2|Bacteria,1N3F7@1224|Proteobacteria,2VX2N@28216|Betaproteobacteria,4AJ13@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Catalyzes the conversion of maleate to fumarate	-	-	4.1.1.76,5.2.1.1	ko:K01799,ko:K06033	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
k59_76137_1	1353276.JADR01000007_gene1464	3.58e-10	63.9	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1HYE4@117743|Flavobacteriia	976|Bacteroidetes	T	Universal stress protein	uspA	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_759428_1	1123367.C666_08530	7.23e-57	191.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2VHA7@28216|Betaproteobacteria,2KUYZ@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_924933_1	380703.AHA_0778	4.55e-85	263.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1Y46X@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_271548_1	1380394.JADL01000013_gene701	7.68e-52	167.0	COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,2U5DE@28211|Alphaproteobacteria,2JUSB@204441|Rhodospirillales	204441|Rhodospirillales	S	Thioesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_336883_1	945713.IALB_0843	2.82e-19	94.4	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9,Laminin_G_3
k59_827078_1	1300345.LF41_1696	6e-45	165.0	COG4773@1|root,COG4773@2|Bacteria,1MWUQ@1224|Proteobacteria,1SJYF@1236|Gammaproteobacteria,1X5UY@135614|Xanthomonadales	135614|Xanthomonadales	P	Outer membrane receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_924947_1	867900.Celly_2511	4.32e-27	111.0	COG1409@1|root,COG1409@2|Bacteria,4NW6R@976|Bacteroidetes,1I81S@117743|Flavobacteriia	976|Bacteroidetes	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_369223_1	1444309.JAQG01000003_gene4442	3.66e-22	102.0	COG3385@1|root,COG3385@2|Bacteria,1VDW5@1239|Firmicutes,4HMDF@91061|Bacilli,26SXH@186822|Paenibacillaceae	91061|Bacilli	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_141178_2	562973.HMPREF0059_01515	3.53e-17	79.3	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4D3CV@85005|Actinomycetales	201174|Actinobacteria	GK	cog cog1940	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_858981_1	1121937.AUHJ01000014_gene2622	8.62e-52	171.0	COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,1RNBU@1236|Gammaproteobacteria,464UP@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	NIF3 (NGG1p interacting factor 3)	ybgI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896	-	-	-	-	-	-	-	-	-	-	NIF3
k59_858981_2	765914.ThisiDRAFT_2725	5.48e-09	59.3	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X0EW@135613|Chromatiales	135613|Chromatiales	O	Trypsin	-	-	-	ko:K04691	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_696547_1	266265.Bxe_B0283	1.13e-106	324.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2W8ET@28216|Betaproteobacteria,1KCUI@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_400485_2	1120966.AUBU01000006_gene3209	2.02e-43	150.0	28KVZ@1|root,2ZACF@2|Bacteria,4NIZZ@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_400485_3	1120966.AUBU01000006_gene3208	2.13e-26	107.0	2BQG9@1|root,32JBP@2|Bacteria,4NREU@976|Bacteroidetes,47URQ@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_891164_2	95619.PM1_0205095	9.86e-24	95.5	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluE	-	5.4.99.20,5.4.99.22	ko:K06178,ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
k59_827089_1	1000565.METUNv1_00557	8.42e-68	215.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,2KVHM@206389|Rhodocyclales	206389|Rhodocyclales	G	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_696562_1	436308.Nmar_0229	2.02e-45	161.0	COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
k59_696562_2	1229909.NSED_00975	1.16e-24	95.1	COG0526@1|root,arCOG01972@2157|Archaea,41T6S@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_529341_1	1089551.KE386572_gene3616	1.55e-85	276.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4BRB0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_336911_1	1255043.TVNIR_1214	1.33e-125	365.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1WWMZ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_598237_1	1266925.JHVX01000003_gene607	9.75e-102	310.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VZIT@28216|Betaproteobacteria,371QJ@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Trypsin	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_630693_1	402881.Plav_1354	1.85e-82	259.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,1JNC2@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Saccharopine dehydrogenase C-terminal domain	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_237215_1	748658.KB907317_gene394	3.89e-247	684.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1WWV0@135613|Chromatiales	135613|Chromatiales	E	aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_237215_2	1282356.H045_15860	2.1e-20	90.9	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1YMSM@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	E	homoserine dehydrogenase	hom	-	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_43156_1	497964.CfE428DRAFT_4456	1.62e-22	100.0	COG4745@1|root,COG4745@2|Bacteria,46T45@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_500620_1	941449.dsx2_3429	3.69e-54	185.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42NGE@68525|delta/epsilon subdivisions,2WT0N@28221|Deltaproteobacteria,2M9YF@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Sodium sulphate symporter	-	-	-	ko:K03319,ko:K11106	-	-	-	-	ko00000,ko02000	2.A.47,2.A.47.3.3	-	-	Na_sulph_symp
k59_759463_1	762376.AXYL_03819	9.18e-203	581.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2VJ5N@28216|Betaproteobacteria,3T1HP@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_108572_1	420662.Mpe_A1565	2.21e-96	293.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2VJII@28216|Betaproteobacteria,1KJ4Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	PHB de-polymerase C-terminus	phaZ2	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
k59_989447_1	1121346.KB899824_gene3032	2.95e-16	83.6	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,4H9ZM@91061|Bacilli,26S70@186822|Paenibacillaceae	91061|Bacilli	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	2.4.2.8,6.3.4.19	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01132,R01229,R02142,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_529359_2	1408418.JNJH01000026_gene617	3.55e-69	214.0	COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,2TSQ1@28211|Alphaproteobacteria,2JRQ3@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_369272_1	765911.Thivi_1370	1.05e-56	187.0	COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1WYC3@135613|Chromatiales	135613|Chromatiales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_108581_1	1266925.JHVX01000011_gene1466	2.69e-136	394.0	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,372BS@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Oxidoreductase FAD-binding domain	ascD	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_729076_2	1122180.Lokhon_02951	3.81e-27	102.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2U93P@28211|Alphaproteobacteria,2P8YJ@245186|Loktanella	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_827139_1	279714.FuraDRAFT_1546	1.5e-168	489.0	COG0598@1|root,COG0598@2|Bacteria,1R7FC@1224|Proteobacteria,2VKBA@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Magnesium transport protein CorA	-	-	-	-	-	-	-	-	-	-	-	-	CorA
k59_500650_1	543728.Vapar_0779	1.1e-69	216.0	COG5588@1|root,COG5588@2|Bacteria,1MWK3@1224|Proteobacteria,2VMAI@28216|Betaproteobacteria,4AHFW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
k59_434495_1	330214.NIDE1131	7.06e-202	583.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
k59_989471_1	1052684.PPM_2152	3.01e-37	137.0	COG0500@1|root,COG2226@2|Bacteria,1V0UT@1239|Firmicutes,4IT1S@91061|Bacilli,2777J@186822|Paenibacillaceae	91061|Bacilli	Q	sAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_598280_1	1123355.JHYO01000019_gene1689	7.16e-71	228.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2TTAH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	MA20_26550	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_827141_1	864051.BurJ1DRAFT_3799	3.05e-58	197.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,2W5VT@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1017039_1	639282.DEFDS_1656	1.63e-27	114.0	2B54A@1|root,311EQ@2|Bacteria,2GFM3@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_565857_1	1038859.AXAU01000008_gene2022	1.95e-136	402.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3JVBW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_859053_1	1132855.KB913035_gene2243	6.73e-53	186.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KKYV@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_989485_1	330214.NIDE0601	4.89e-36	132.0	COG1295@1|root,COG1295@2|Bacteria,3J17V@40117|Nitrospirae	40117|Nitrospirae	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_925035_1	323848.Nmul_A0474	2.87e-84	265.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,372AD@32003|Nitrosomonadales	28216|Betaproteobacteria	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_630749_2	1379281.AVAG01000033_gene426	6.77e-22	92.4	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,2M7SR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_400547_1	697282.Mettu_3282	1.2e-138	403.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XEVC@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4478)	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
k59_925039_1	864069.MicloDRAFT_00027180	3.55e-108	319.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_141270_1	1136417.AZWE01000077_gene274	1.08e-25	107.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,4DE6S@85008|Micromonosporales	201174|Actinobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_630757_1	1397527.Q670_13075	6.65e-10	60.5	COG3203@1|root,COG3203@2|Bacteria,1MWUN@1224|Proteobacteria,1RZ26@1236|Gammaproteobacteria,1XJPW@135619|Oceanospirillales	135619|Oceanospirillales	M	COG3203 Outer membrane protein (porin)	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
k59_786972_1	670307.HYPDE_38973	2.03e-67	205.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,3N6Z8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
k59_434525_1	987059.RBXJA2T_02220	5.05e-98	296.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,1KJGH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_565885_1	1192759.AKIB01000088_gene2333	2.73e-06	53.1	COG4773@1|root,COG4773@2|Bacteria,1Q323@1224|Proteobacteria,2TW33@28211|Alphaproteobacteria,2K10M@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_141278_1	1267535.KB906767_gene4734	2.44e-57	193.0	COG0215@1|root,COG0215@2|Bacteria,3Y2PW@57723|Acidobacteria,2JHIQ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_369320_1	323848.Nmul_A0590	2.91e-55	181.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,37239@32003|Nitrosomonadales	28216|Betaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_663897_1	743720.Psefu_1286	1.84e-23	99.0	2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,1S8Z8@1236|Gammaproteobacteria,1YWQG@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Thermostable hemolysin	-	-	-	-	-	-	-	-	-	-	-	-	T_hemolysin
k59_696658_1	880073.Calab_1842	2.6e-35	137.0	COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_529397_1	742733.HMPREF9469_05017	1.73e-54	184.0	292XD@1|root,2ZQEV@2|Bacteria,1V48I@1239|Firmicutes,24GZD@186801|Clostridia,221AZ@1506553|Lachnoclostridium	186801|Clostridia	S	COG NOG18825 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_407536_1	1155718.KB891895_gene2407	1.3e-66	225.0	COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,2I9Q1@201174|Actinobacteria	201174|Actinobacteria	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_182165_1	1122236.KB905141_gene1811	3.47e-12	62.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KMZ0@206350|Nitrosomonadales	206350|Nitrosomonadales	C	PFAM cytochrome c, class I	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
k59_182165_2	1207063.P24_18531	4.31e-44	152.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JQSZ@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_84751_1	880073.Calab_2451	1.1e-35	127.0	COG2391@1|root,COG2391@2|Bacteria,2NRQM@2323|unclassified Bacteria	2|Bacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Rhodanese,Sulf_transp
k59_84751_2	452637.Oter_1463	9.57e-49	159.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_214477_1	323848.Nmul_A1846	2.08e-146	424.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VJ6T@28216|Betaproteobacteria,372WA@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3501
k59_574383_2	582744.Msip34_0053	6.01e-229	653.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KKTM@206350|Nitrosomonadales	206350|Nitrosomonadales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_19353_1	1101195.Meth11DRAFT_1813	1.08e-15	84.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,2KNF2@206350|Nitrosomonadales	206350|Nitrosomonadales	Q	TIGRFAM outer membrane adhesin like proteiin	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind
k59_377330_1	1173029.JH980292_gene1484	5.02e-52	179.0	COG0104@1|root,COG0104@2|Bacteria,1G147@1117|Cyanobacteria,1H831@1150|Oscillatoriales	1117|Cyanobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_672533_1	243231.GSU2518	8.16e-18	80.5	COG0607@1|root,COG0607@2|Bacteria,1RM5B@1224|Proteobacteria,42TBJ@68525|delta/epsilon subdivisions,2WPIJ@28221|Deltaproteobacteria,43VER@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_182179_1	58123.JOFJ01000018_gene4377	3.59e-15	72.4	COG0745@1|root,COG0745@2|Bacteria,2IQWH@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ompR	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_182179_2	1033733.CAEK01000007_gene1601	4.57e-06	50.4	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,22GF2@1570339|Peptoniphilaceae	186801|Clostridia	KLT	Kinase domain protein	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_244265_1	1082931.KKY_2603	5.48e-92	275.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,3N8SG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_766590_1	1191523.MROS_2770	7.44e-05	46.2	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	usp-3	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_766590_2	1123376.AUIU01000011_gene980	2.55e-36	131.0	2C5J8@1|root,30F9Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_997765_1	215803.DB30_0041	8.24e-29	117.0	COG0457@1|root,COG0457@2|Bacteria,1R64F@1224|Proteobacteria,42Q6D@68525|delta/epsilon subdivisions,2WKT0@28221|Deltaproteobacteria,2YYVN@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
k59_377341_1	234267.Acid_1641	2.16e-36	134.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.1.3.15,1.1.3.46	ko:K00104,ko:K16422	ko00261,ko00630,ko01055,ko01100,ko01110,ko01120,ko01130,map00261,map00630,map01055,map01100,map01110,map01120,map01130	-	R00475,R06633	RC00042,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_51465_1	1149133.ppKF707_1116	5e-61	214.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,1TBFS@1236|Gammaproteobacteria,1YHD1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_442617_1	395493.BegalDRAFT_1747	2.23e-74	238.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,46009@72273|Thiotrichales	72273|Thiotrichales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_966252_1	159087.Daro_0584	1.85e-07	52.0	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,2VHA4@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_966252_2	765911.Thivi_2590	2.14e-46	155.0	COG1047@1|root,COG1047@2|Bacteria,1RH9C@1224|Proteobacteria,1S63R@1236|Gammaproteobacteria,1X2G4@135613|Chromatiales	135613|Chromatiales	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_790131_1	933262.AXAM01000022_gene3233	4.5e-144	410.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MI6N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	qrcC	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
k59_933653_1	1121396.KB892913_gene117	3.94e-62	201.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2X5JU@28221|Deltaproteobacteria,2MPFA@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_472695_1	1396141.BATP01000019_gene1716	1.17e-16	77.4	COG1131@1|root,COG1131@2|Bacteria,46UCI@74201|Verrucomicrobia,2IU5T@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_472695_2	644801.Psest_1613	4.74e-72	224.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1Z17S@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_214519_1	272558.10173025	1.05e-42	149.0	COG2808@1|root,COG2808@2|Bacteria,1TXED@1239|Firmicutes,4HEZS@91061|Bacilli,1ZDPR@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	paiB	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
k59_311410_1	305700.B447_02096	7.56e-66	214.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,2KUHY@206389|Rhodocyclales	206389|Rhodocyclales	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_311410_2	216591.BCAL3014	4.82e-07	50.1	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2VIGI@28216|Betaproteobacteria,1K0EK@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_182213_1	1189612.A33Q_0323	1.07e-57	195.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes	976|Bacteroidetes	Q	COG1228 Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_933659_1	1123257.AUFV01000016_gene3459	2.65e-14	73.2	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1X8XV@135614|Xanthomonadales	135614|Xanthomonadales	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_442635_2	713586.KB900536_gene305	2.31e-76	235.0	COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,1RQ95@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the SfsA family	sfsA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044238,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
k59_933660_1	1469245.JFBG01000009_gene562	2.28e-50	177.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,1RRJR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EH	Belongs to the TPP enzyme family	mdlC	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_509154_1	1229909.NSED_09115	1.06e-95	291.0	COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota	651137|Thaumarchaeota	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_509154_2	436308.Nmar_1713	1.07e-62	196.0	COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
k59_377374_1	314345.SPV1_00857	3.5e-46	161.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria	1224|Proteobacteria	S	Major facilitator Superfamily	MA20_25070	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_377374_2	391165.GbCGDNIH1_2046	1.89e-17	77.4	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,2JSWF@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the UPF0260 family	-	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_606657_1	331869.BAL199_24289	5.16e-29	109.0	COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,2VC8M@28211|Alphaproteobacteria,4BSKF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_606657_2	620914.JH621248_gene3101	7.57e-25	97.4	COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,1HYH3@117743|Flavobacteriia,2YH7A@290174|Aquimarina	976|Bacteroidetes	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_899127_1	795666.MW7_1377	4.3e-05	48.5	COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2VIES@28216|Betaproteobacteria,1K1UM@119060|Burkholderiaceae	28216|Betaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_899127_2	365046.Rta_22820	6.8e-44	152.0	COG0845@1|root,COG0845@2|Bacteria,1R99C@1224|Proteobacteria,2VQDD@28216|Betaproteobacteria,4AI1Y@80864|Comamonadaceae	28216|Betaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
k59_705425_1	1173020.Cha6605_4325	4.22e-35	129.0	COG0730@1|root,COG0730@2|Bacteria,1G72I@1117|Cyanobacteria	1117|Cyanobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_672594_1	195250.CM001776_gene3418	1.09e-10	63.9	COG0745@1|root,COG0745@2|Bacteria,1GHYV@1117|Cyanobacteria,1H36Y@1129|Synechococcus	1117|Cyanobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_244313_1	2340.JV46_20180	8.78e-31	115.0	2C8PG@1|root,32RMK@2|Bacteria,1N0UQ@1224|Proteobacteria,1SBBP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_244313_2	391735.Veis_0237	1.44e-11	67.4	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,4AJ1A@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_149792_1	1385517.N800_13180	2.96e-42	157.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_672598_1	247490.KSU1_B0100	1.62e-54	181.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_407602_1	582744.Msip34_0554	4.63e-59	187.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2VQ1Q@28216|Betaproteobacteria,2KMSR@206350|Nitrosomonadales	206350|Nitrosomonadales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_407602_2	1122599.AUGR01000025_gene1455	7.39e-35	124.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria,1XK11@135619|Oceanospirillales	135619|Oceanospirillales	O	Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
k59_899138_1	1123517.JOMR01000001_gene620	9.73e-35	133.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,460DY@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_509175_1	765912.Thimo_0089	5e-64	207.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_835975_1	190650.CC_0808	2.92e-07	52.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSW4@28211|Alphaproteobacteria,2KI69@204458|Caulobacterales	204458|Caulobacterales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_835975_2	28229.ND2E_3370	4.8e-54	189.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q61E@267889|Colwelliaceae	1236|Gammaproteobacteria	U	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_19441_1	983544.Lacal_1140	8.44e-13	67.8	COG1108@1|root,COG1108@2|Bacteria,4NH3D@976|Bacteroidetes,1HY97@117743|Flavobacteriia	976|Bacteroidetes	P	ABC-type Mn2 Zn2 transport systems permease components	mntD	-	-	ko:K11709	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC-3
k59_19441_2	880073.Calab_1771	1.76e-38	140.0	COG1108@1|root,COG1108@2|Bacteria,2NPC2@2323|unclassified Bacteria	2|Bacteria	U	ABC 3 transport family	mntC	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944	-	ko:K11708	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC-3,Fe_dep_repr_C
k59_766650_1	330214.NIDE2655	2.2e-98	307.0	COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,3J11V@40117|Nitrospirae	40117|Nitrospirae	T	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	HAMP,MCPsignal
k59_51520_1	1411123.JQNH01000001_gene58	7.67e-96	288.0	COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria,2TTT8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	TRAP-type C4-dicarboxylate transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_639055_1	247634.GPB2148_1120	2.98e-95	296.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J88C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
k59_705457_1	1120792.JAFV01000001_gene2602	9.49e-48	162.0	COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,2U5XC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
k59_19447_1	234267.Acid_6996	4.44e-133	412.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,3Y415@57723|Acidobacteria	57723|Acidobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_19451_1	402881.Plav_3632	6.31e-83	266.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,1JN2P@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_345393_2	370438.PTH_0467	3.55e-54	184.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,26152@186807|Peptococcaceae	186801|Clostridia	S	pfam ammecr1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
k59_509204_1	911239.CF149_13390	1.35e-20	90.1	COG3194@1|root,COG3194@2|Bacteria,1RE91@1224|Proteobacteria,1S4PA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source	allA	-	4.3.2.3	ko:K01483	ko00230,ko01100,map00230,map01100	-	R00776	RC00153,RC00379	ko00000,ko00001,ko01000	-	-	-	Ureidogly_lyase
k59_533536_1	335543.Sfum_1324	1.89e-23	98.6	COG4012@1|root,COG4012@2|Bacteria,1R94F@1224|Proteobacteria,42Q7K@68525|delta/epsilon subdivisions,2WK3Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Domain of unkown function DUF1786	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
k59_533536_2	1380391.JIAS01000020_gene1537	3.34e-10	61.6	COG1744@1|root,COG1744@2|Bacteria,1MVU5@1224|Proteobacteria,2TTTH@28211|Alphaproteobacteria,2JQGQ@204441|Rhodospirillales	204441|Rhodospirillales	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	-	-	-	-	-	-	-	-	-	Bmp
k59_51535_1	1121943.KB899993_gene235	5.33e-44	159.0	COG0637@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,1RNIQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495	Trehalose_PPase
k59_377424_1	1121405.dsmv_3107	3.75e-72	241.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MJ5T@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_345397_1	945713.IALB_1775	9.47e-73	235.0	COG0587@1|root,COG0587@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	dnaE-2	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
k59_509206_1	1380394.JADL01000014_gene240	2.59e-106	317.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,2JRNW@204441|Rhodospirillales	204441|Rhodospirillales	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_509206_2	396588.Tgr7_1820	1.12e-15	72.0	COG1977@1|root,COG1977@2|Bacteria,1N9QE@1224|Proteobacteria	1224|Proteobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_899172_1	706587.Desti_3348	1.25e-77	243.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,42MEN@68525|delta/epsilon subdivisions,2WIYF@28221|Deltaproteobacteria,2MRF9@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_84864_1	159087.Daro_1204	1.65e-115	348.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,2KV9F@206389|Rhodocyclales	206389|Rhodocyclales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_966330_1	868864.Dester_0907	7.64e-19	84.7	COG0663@1|root,COG0663@2|Bacteria,2G3ZR@200783|Aquificae	200783|Aquificae	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_311478_1	1205680.CAKO01000042_gene5416	3.09e-17	80.9	COG0715@1|root,COG0715@2|Bacteria,1MWC5@1224|Proteobacteria,2TSS8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_534027_1	436308.Nmar_1761	5.59e-62	196.0	COG1878@1|root,arCOG02462@2157|Archaea,41SK8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_534027_2	436308.Nmar_1762	9.05e-44	143.0	COG1522@1|root,arCOG01117@2157|Archaea,41T58@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
k59_346424_1	1123290.AUDQ01000004_gene243	1.28e-38	138.0	COG0819@1|root,COG0819@2|Bacteria,1TPK0@1239|Firmicutes,4HD73@91061|Bacilli,26I5H@186818|Planococcaceae	91061|Bacilli	K	TENA/THI-4/PQQC family	tenA	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
k59_215593_1	1229909.NSED_06295	3.07e-49	158.0	arCOG08700@1|root,arCOG08700@2157|Archaea,41SV2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_215593_2	1229909.NSED_06300	3.03e-21	85.9	arCOG10573@1|root,arCOG10573@2157|Archaea,41T8W@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_767616_1	323848.Nmul_A2468	3.33e-50	179.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_319314_1	1415778.JQMM01000001_gene398	5.77e-79	262.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1J52Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_28197_1	326427.Cagg_3712	4.04e-07	51.2	COG2359@1|root,COG2359@2|Bacteria,2G77N@200795|Chloroflexi,375SU@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Stage V sporulation protein S	-	-	-	ko:K06416	-	-	-	-	ko00000	-	-	-	SpoVS
k59_28197_2	329726.AM1_1841	9.98e-06	48.9	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1GQUE@1117|Cyanobacteria	1117|Cyanobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF
k59_190548_1	580332.Slit_2572	1.6e-53	174.0	arCOG09454@1|root,30G4A@2|Bacteria,1N61J@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_223002_1	1232410.KI421413_gene844	1.18e-106	318.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,43S8G@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-2	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,Molybdopterin,Molydop_binding
k59_223002_2	1232410.KI421413_gene845	5.87e-68	209.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,42V63@68525|delta/epsilon subdivisions,2WRVB@28221|Deltaproteobacteria,43SKF@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_59838_1	41431.PCC8801_0005	2.45e-68	215.0	COG2020@1|root,COG2020@2|Bacteria,1G4HN@1117|Cyanobacteria,3KGIV@43988|Cyanothece	1117|Cyanobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
k59_415203_1	1123228.AUIH01000006_gene2285	3.22e-52	175.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1XINF@135619|Oceanospirillales	135619|Oceanospirillales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_774443_1	420662.Mpe_A3762	8.24e-99	296.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,1KJHY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_59844_1	3988.XP_002536083.1	5.67e-62	197.0	COG1131@1|root,KOG0059@2759|Eukaryota	2759|Eukaryota	V	ATPase activity, coupled to transmembrane movement of substances	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_190558_1	945713.IALB_1751	6.36e-47	173.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	CP_0155	-	-	ko:K08307,ko:K12204	-	-	-	-	ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	LysM,SLT,T4SS_TraI
k59_354083_1	153948.NAL212_3155	5.69e-17	73.9	2EPEP@1|root,33H1B@2|Bacteria,1NHDJ@1224|Proteobacteria,2VXNY@28216|Betaproteobacteria,373N9@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3460
k59_354083_2	305900.GV64_09685	1.22e-26	107.0	28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria,1RP8T@1236|Gammaproteobacteria,1XIH6@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_480113_1	290397.Adeh_2927	4.04e-38	145.0	COG5492@1|root,COG5492@2|Bacteria,1QY8X@1224|Proteobacteria,43CAR@68525|delta/epsilon subdivisions,2X7M8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_28215_1	1123392.AQWL01000002_gene1728	1.88e-11	60.5	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2VSJ0@28216|Betaproteobacteria,1KRPA@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
k59_28215_2	1244869.H261_18180	3.19e-07	54.7	COG0589@1|root,COG0589@2|Bacteria,1RG30@1224|Proteobacteria,2U7DC@28211|Alphaproteobacteria,2JRXD@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_518220_1	1123392.AQWL01000004_gene2637	5.23e-99	315.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_907568_1	1123255.JHYS01000002_gene2487	5.92e-60	200.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,2WGIZ@28216|Betaproteobacteria,4A9M2@80864|Comamonadaceae	28216|Betaproteobacteria	G	Major facilitator superfamily	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
k59_647696_1	177437.HRM2_04880	1.14e-116	357.0	COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_845161_1	580332.Slit_1269	3.5e-27	109.0	COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,PEGA
k59_845161_2	1266925.JHVX01000009_gene151	2.23e-46	166.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,372I1@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_518237_1	102125.Xen7305DRAFT_00043610	9.33e-32	122.0	COG0589@1|root,COG0589@2|Bacteria,1GDD7@1117|Cyanobacteria	1117|Cyanobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_583626_1	1458275.AZ34_10180	6.63e-44	154.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,4AABT@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_583626_2	1366050.N234_35125	2.1e-45	150.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VQ0S@28216|Betaproteobacteria,1K79X@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
k59_518242_1	945713.IALB_0746	2.17e-43	160.0	COG1086@1|root,COG1216@1|root,COG2148@1|root,COG1086@2|Bacteria,COG1216@2|Bacteria,COG2148@2|Bacteria	2|Bacteria	M	undecaprenyl-phosphate glucose phosphotransferase activity	wbbL	-	-	ko:K03606,ko:K07011	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
k59_59871_1	1211115.ALIQ01000225_gene1776	1.82e-44	155.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria,3N9ZJ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding protein	potF	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_6,SBP_bac_8
k59_59871_2	84531.JMTZ01000036_gene490	1.49e-16	79.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1X37D@135614|Xanthomonadales	135614|Xanthomonadales	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	-	ko:K11076	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	ABC_tran,TOBE_2
k59_1006289_1	1232410.KI421424_gene1839	1.35e-97	301.0	COG0477@1|root,COG2814@2|Bacteria,1QUY6@1224|Proteobacteria,43DH9@68525|delta/epsilon subdivisions,2X8P2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_845174_2	547045.NEISICOT_00357	1.4e-30	119.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,2KPIR@206351|Neisseriales	206351|Neisseriales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_385606_1	323848.Nmul_A0884	2.62e-56	195.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,372I7@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_125873_1	580332.Slit_1228	8.92e-85	274.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria	1224|Proteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_681792_2	926569.ANT_05300	8.32e-75	243.0	COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_907594_1	644282.Deba_0527	8.51e-34	129.0	COG0845@1|root,COG0845@2|Bacteria,1R3U4@1224|Proteobacteria,43D29@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	HlyD family secretion protein	MA20_09450	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_942730_1	395495.Lcho_1780	3.39e-119	358.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VHHD@28216|Betaproteobacteria,1KJ5Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TRAP dicarboxylate transporter, DctM subunit	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	DctM
k59_537925_1	1118054.CAGW01000033_gene4061	1e-52	179.0	COG0111@1|root,COG0111@2|Bacteria,1TQ7W@1239|Firmicutes,4HDEC@91061|Bacilli,26WIR@186822|Paenibacillaceae	91061|Bacilli	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_845179_1	1122929.KB908219_gene1726	8.35e-15	75.9	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phenazine biosynthesis protein PhzF	phzF	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
k59_845179_2	452637.Oter_4105	1.85e-64	202.0	COG2818@1|root,COG2818@2|Bacteria,46VJV@74201|Verrucomicrobia,3K9KD@414999|Opitutae	414999|Opitutae	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_747005_1	1382306.JNIM01000001_gene466	1.58e-58	199.0	COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi	200795|Chloroflexi	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_714527_1	794903.OPIT5_26535	7.32e-70	220.0	COG0778@1|root,COG0778@2|Bacteria,46YQM@74201|Verrucomicrobia,3KA08@414999|Opitutae	414999|Opitutae	C	Nitroreductase family	-	-	1.5.1.39	ko:K19286	ko00740,ko01100,map00740,map01100	-	R05705,R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
k59_59891_1	395495.Lcho_3916	1.1e-105	327.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1KIY8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
k59_793704_1	335283.Neut_2392	1.44e-75	233.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,372K7@32003|Nitrosomonadales	28216|Betaproteobacteria	C	cytochrome c oxidase, subunit III	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_451182_1	420662.Mpe_A1015	2.19e-49	167.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2VIRF@28216|Betaproteobacteria,1KJBP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_942746_1	1357423.S5MCZ1_9CAUD	1.98e-39	140.0	4QDKB@10239|Viruses,4QVIT@35237|dsDNA viruses  no RNA stage,4QPPF@28883|Caudovirales,4QINJ@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1006312_1	330214.NIDE1681	2.35e-88	266.0	COG0805@1|root,COG0805@2|Bacteria,3J0PJ@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_158539_1	937777.Deipe_3230	1.08e-49	178.0	COG4666@1|root,COG4666@2|Bacteria,1WIWE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_451187_1	443598.AUFA01000011_gene564	3.29e-27	102.0	COG4274@1|root,COG4274@2|Bacteria,1RHJ3@1224|Proteobacteria,2U9XS@28211|Alphaproteobacteria,3JZUN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
k59_451187_2	316274.Haur_1478	4.17e-15	73.9	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi,375BD@32061|Chloroflexia	32061|Chloroflexia	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_747024_1	323848.Nmul_A1097	7.02e-109	336.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,372H6@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_907621_1	1123504.JQKD01000019_gene5539	1.4e-65	219.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,2VH0U@28216|Betaproteobacteria,4AAMR@80864|Comamonadaceae	28216|Betaproteobacteria	J	Translation elongation factor	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_354152_1	414684.RC1_0713	1.7e-30	110.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria,2JT6W@204441|Rhodospirillales	204441|Rhodospirillales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_354152_2	990285.RGCCGE502_07486	1.88e-26	104.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,4B9GD@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_451189_1	864051.BurJ1DRAFT_2877	7.54e-45	150.0	2AIHJ@1|root,318ZE@2|Bacteria,1Q18Q@1224|Proteobacteria,2W6AT@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_681823_1	580332.Slit_2233	6e-116	365.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,44UYD@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_538593_1	228410.NE1473	1.62e-84	272.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,3727Q@32003|Nitrosomonadales	28216|Betaproteobacteria	L	UvrD REP	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_61065_1	582744.Msip34_0969	1.31e-106	312.0	COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,2VH6D@28216|Betaproteobacteria,2KM8N@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
k59_127078_1	864073.HFRIS_003073	3.69e-44	160.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,473A1@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain, Two-component sensor kinase N-terminal	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_224207_1	748280.NH8B_3079	4.78e-64	203.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,2KQEW@206351|Neisseriales	206351|Neisseriales	I	squalene synthase HpnC	hpnC	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
k59_61069_1	1254432.SCE1572_29485	1.27e-31	124.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	alkR	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
k59_95179_2	1479237.JMLY01000001_gene2920	4.06e-35	132.0	28H52@1|root,2ZADT@2|Bacteria,1R8NH@1224|Proteobacteria,1RQUB@1236|Gammaproteobacteria,46DG6@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_683065_1	177437.HRM2_36780	3.95e-33	129.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_943981_1	399739.Pmen_2424	1.02e-39	147.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1YEWN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iEC042_1314.EC042_2517,iSbBS512_1146.SbBS512_E2652	Proton_antipo_M
k59_416378_1	216591.BCAL1138	4.47e-21	89.0	COG5516@1|root,COG5516@2|Bacteria,1REGN@1224|Proteobacteria,2VU4F@28216|Betaproteobacteria,1K1MG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
k59_224214_1	1235793.C809_03706	1.18e-51	192.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,27JAZ@186928|unclassified Lachnospiraceae	186801|Clostridia	KLT	PASTA	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_127093_1	203122.Sde_1598	4.41e-83	266.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,46466@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	arginine decarboxylase	speA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283	Orn_Arg_deC_N
k59_224216_2	545276.KB898725_gene763	2.94e-38	133.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1WYWV@135613|Chromatiales	135613|Chromatiales	S	Stringent starvation protein B	-	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
k59_943990_1	686578.AFFX01000006_gene3133	1.31e-62	199.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	phosphate regulon transcriptional regulatory protein PhoB	phoB	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_320514_1	882378.RBRH_02206	4.75e-23	99.8	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,1K0BN@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Ammonium transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_320514_2	536019.Mesop_1067	3.75e-40	135.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,43K0V@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_877265_1	330214.NIDE1735	1.33e-33	126.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	VP1245	-	-	-	-	-	-	-	-	-	-	-	DUF3369,EAL,GAF_2,GGDEF,HATPase_c,HD,HisKA,Response_reg,cNMP_binding
k59_519513_2	1131266.ARWQ01000010_gene52	2.41e-32	121.0	COG1948@1|root,arCOG04206@2157|Archaea,41SIH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	ERCC4 domain	-	-	-	ko:K10848	ko03420,ko03460,map03420,map03460	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	ERCC4,HHH_5
k59_748313_1	1337093.MBE-LCI_3064	5.35e-48	170.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,2P8F7@245186|Loktanella	28211|Alphaproteobacteria	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_355419_1	566466.NOR53_2871	4.1e-68	218.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,1J8IM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Glucose / Sorbosone dehydrogenase	yliI	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
k59_648954_1	706587.Desti_3265	5.86e-124	371.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_95210_2	765914.ThisiDRAFT_2006	3.21e-89	269.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,1SZ29@1236|Gammaproteobacteria,1X2IZ@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_416402_1	671143.DAMO_3015	1.47e-54	192.0	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
k59_519524_1	1244869.H261_16336	3.15e-07	58.2	COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,2TW0C@28211|Alphaproteobacteria,2JZ4C@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0591 Na proline symporter	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_7,Response_reg
k59_584994_1	717785.HYPMC_1228	4.42e-31	115.0	2E6JI@1|root,3316K@2|Bacteria,1PP48@1224|Proteobacteria,2UT9Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_720493_2	744979.R2A130_3241	9.14e-122	362.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2TR1C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0226 ABC-type phosphate transport system, periplasmic component	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_883419_1	685035.ADAE01000019_gene357	1.61e-23	104.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,2U17C@28211|Alphaproteobacteria,2K07Y@204457|Sphingomonadales	204457|Sphingomonadales	P	permease	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
k59_492111_1	1255043.TVNIR_0952	9.31e-63	203.0	COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,1S4TK@1236|Gammaproteobacteria,1X0P2@135613|Chromatiales	135613|Chromatiales	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_492111_2	713586.KB900536_gene937	2.02e-19	87.8	COG4191@1|root,COG4191@2|Bacteria,1QVHZ@1224|Proteobacteria,1S2DC@1236|Gammaproteobacteria,1WZY5@135613|Chromatiales	135613|Chromatiales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_720496_1	1163408.UU9_06289	2.75e-26	101.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1X6FA@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaC
k59_720496_2	272942.RCAP_rcc02842	8.74e-11	59.7	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2UF4F@28211|Alphaproteobacteria,1FC2G@1060|Rhodobacter	28211|Alphaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_948934_1	1395587.P364_0129205	2.98e-07	50.8	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,4HGZU@91061|Bacilli,26TQV@186822|Paenibacillaceae	91061|Bacilli	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_688019_1	296591.Bpro_4692	2.29e-86	266.0	COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria,2VM3U@28216|Betaproteobacteria,4ABJX@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	3.11.1.2	ko:K19670	ko00440,map00440	-	R00318	RC01309	ko00000,ko00001,ko01000	-	-	-	Phosphodiest
k59_818637_1	56780.SYN_03159	3.03e-27	113.0	COG3547@1|root,COG3547@2|Bacteria,1NCHY@1224|Proteobacteria,42TM4@68525|delta/epsilon subdivisions,2WR4U@28221|Deltaproteobacteria,2MSGS@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_328700_1	62928.azo1147	2.25e-97	295.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,2KUTI@206389|Rhodocyclales	206389|Rhodocyclales	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_818644_1	640081.Dsui_0118	1.58e-33	117.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2VSCX@28216|Betaproteobacteria,2KWQF@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
k59_818644_2	379731.PST_3181	5.88e-37	134.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1Z0B8@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006464,GO:0006479,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0016043,GO:0016740,GO:0016741,GO:0018364,GO:0019222,GO:0019538,GO:0022411,GO:0032259,GO:0032984,GO:0034641,GO:0034645,GO:0036009,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043414,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_426537_1	1265502.KB905931_gene1748	1.57e-108	325.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2VMN7@28216|Betaproteobacteria,4AC7E@80864|Comamonadaceae	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.215,1.1.1.79,1.1.1.81	ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R01739	RC00031,RC00042,RC00084	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_524660_1	1220582.RRU01S_29_01180	5.69e-203	573.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria,4BP2N@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	tnp*	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_752717_1	1123256.KB907926_gene913	1.98e-32	129.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1X47B@135614|Xanthomonadales	135614|Xanthomonadales	S	DNA internalization-related competence protein ComEC Rec2	comA	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_655372_1	1279019.ARQK01000022_gene162	1.09e-102	305.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales	135613|Chromatiales	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_818670_1	580332.Slit_2472	1.07e-62	201.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2VSTA@28216|Betaproteobacteria,44W6B@713636|Nitrosomonadales	28216|Betaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
k59_883470_1	330214.NIDE1425	2.46e-82	260.0	COG0173@1|root,COG0173@2|Bacteria,3J0FR@40117|Nitrospirae	40117|Nitrospirae	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_883470_2	330214.NIDE1423	1.86e-40	146.0	COG1187@1|root,COG1187@2|Bacteria,3J0RN@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.20,5.4.99.21,5.4.99.22	ko:K06178,ko:K06181,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_67713_1	1304872.JAGC01000003_gene2613	3.03e-41	156.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,42S9Y@68525|delta/epsilon subdivisions,2WNFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_655377_1	1123248.KB893348_gene291	5.19e-42	161.0	COG4585@1|root,COG5002@1|root,COG4585@2|Bacteria,COG5002@2|Bacteria,4NG0M@976|Bacteroidetes,1IXEX@117747|Sphingobacteriia	976|Bacteroidetes	T	Histidine kinase	narQ	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9,PilJ
k59_524682_1	1457250.BBMO01000001_gene1351	1.18e-47	166.0	arCOG06187@1|root,arCOG06187@2157|Archaea,2XTSP@28890|Euryarchaeota,23S9E@183963|Halobacteria	183963|Halobacteria	D	COG1077 Actin-like ATPase involved in cell morphogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_230600_1	522306.CAP2UW1_2025	1.55e-93	292.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,1KPNB@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_35013_1	1089552.KI911559_gene1781	1.85e-12	73.9	COG1352@1|root,COG2201@1|root,COG3920@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2TW1K@28211|Alphaproteobacteria,2JZ0T@204441|Rhodospirillales	204441|Rhodospirillales	NT	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CheB_methylest,CheR,CheR_N,HWE_HK,PAS_10
k59_198230_1	357808.RoseRS_0353	5.14e-57	192.0	COG4467@1|root,COG4467@2|Bacteria,2G8CX@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
k59_426570_1	1163617.SCD_n01470	7.47e-90	293.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_948998_1	1380387.JADM01000002_gene2011	1.4e-52	184.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_100256_2	1182590.BN5_00336	3.47e-58	194.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,1YDBV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_2227_1	862908.BMS_0013	2.02e-67	216.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2MU0C@213481|Bdellovibrionales,2WIP2@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1624	RibD_C,dCMP_cyt_deam_1
k59_492190_2	1054213.HMPREF9946_01700	7.7e-05	44.3	COG4101@1|root,COG4101@2|Bacteria,1RB8W@1224|Proteobacteria,2TUPM@28211|Alphaproteobacteria,2JW9D@204441|Rhodospirillales	204441|Rhodospirillales	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_328756_1	1205753.A989_08469	1.36e-37	144.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5CT@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_296018_1	717231.Flexsi_0289	1.22e-28	116.0	COG1530@1|root,COG1530@2|Bacteria,2GEQF@200930|Deferribacteres	200930|Deferribacteres	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
k59_623629_2	935261.JAGL01000010_gene1908	1.39e-10	60.8	COG1177@1|root,COG1177@2|Bacteria,1NGDC@1224|Proteobacteria,2U2G2@28211|Alphaproteobacteria,43HUT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	cysT	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
k59_459946_1	1163617.SCD_n02621	4.25e-81	249.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_394693_1	1458357.BG58_01485	5.34e-73	238.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2VJ44@28216|Betaproteobacteria,1K0NB@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_721603_1	232721.Ajs_1080	7.43e-117	350.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,4AA7T@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	matB	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_851965_1	648757.Rvan_0355	5.27e-24	105.0	COG2989@1|root,COG3170@1|root,COG2989@2|Bacteria,COG3170@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N69H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_591000_1	323848.Nmul_A2689	1.27e-24	100.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria,371TG@32003|Nitrosomonadales	28216|Betaproteobacteria	H	uroporphyrinogen III synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_753652_1	568706.BN118_1851	7.79e-59	205.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,3T1HA@506|Alcaligenaceae	28216|Betaproteobacteria	EQ	5-oxoprolinase	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_394701_2	448385.sce1378	5.48e-33	121.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,433GE@68525|delta/epsilon subdivisions,2WYHA@28221|Deltaproteobacteria,2YVI4@29|Myxococcales	28221|Deltaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_784636_1	436308.Nmar_0429	1.1e-25	99.8	arCOG08684@1|root,arCOG08684@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_784636_2	436308.Nmar_1300	3.66e-35	122.0	COG0589@1|root,arCOG02053@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,KdpD,Usp
k59_329712_1	880073.Calab_0240	1.82e-21	90.5	COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_362236_1	595537.Varpa_1731	1.11e-83	262.0	COG0477@1|root,COG2814@2|Bacteria,1MVKJ@1224|Proteobacteria,2VK6H@28216|Betaproteobacteria,4AD0T@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
k59_525693_1	876044.IMCC3088_1268	5.34e-73	229.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1J56Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_525693_2	1227457.C451_09285	1.53e-06	49.7	COG0280@1|root,arCOG00855@2157|Archaea,2Y7FX@28890|Euryarchaeota,241GM@183963|Halobacteria	183963|Halobacteria	C	Phosphate acetyl/butaryl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PTA_PTB
k59_982437_1	1229780.BN381_60085	7.17e-26	109.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,3UX3R@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_623655_1	582744.Msip34_0571	4.7e-111	331.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,2KKRJ@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_362241_1	28444.JODQ01000007_gene5160	3e-15	81.3	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4EHQR@85012|Streptosporangiales	201174|Actinobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM,NPCBM_assoc,Sulfatase
k59_459966_1	675635.Psed_0218	4.13e-12	66.6	COG0662@1|root,COG0662@2|Bacteria,2I41N@201174|Actinobacteria,4EANN@85010|Pseudonocardiales	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_819740_1	1278073.MYSTI_05074	1.39e-17	84.0	COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,42SZT@68525|delta/epsilon subdivisions,2WPTX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	Transport permease protein	-	-	-	ko:K09688,ko:K09690	ko02010,map02010	M00249,M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.101,3.A.1.103	-	-	ABC2_membrane
k59_591013_2	1168059.KB899087_gene3084	1.36e-65	213.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,3EY75@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Elongator protein 3	MA20_42330	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_101288_1	935863.AWZR01000005_gene2276	4.18e-64	196.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1X6V9@135614|Xanthomonadales	135614|Xanthomonadales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	VM57_07835	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
k59_819746_1	1042377.AFPJ01000007_gene1863	4.41e-59	204.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,464MR@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Insulinase (Peptidase family M16)	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_851978_2	1357423.S5MV15_9CAUD	1.81e-169	490.0	4QAJ5@10239|Viruses,4QUS9@35237|dsDNA viruses  no RNA stage,4QPY5@28883|Caudovirales,4QHUT@10662|Myoviridae	10662|Myoviridae	S	Major capsid protein Gp23	-	GO:0005575,GO:0019012,GO:0019028,GO:0044423	-	-	-	-	-	-	-	-	-	-	-
k59_3311_1	631454.N177_2471	0.00024	43.1	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,1JNI0@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	GcpE protein	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_3311_2	335283.Neut_2167	1.54e-92	282.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,371PK@32003|Nitrosomonadales	28216|Betaproteobacteria	J	synthetase, class II (G H P	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_591027_1	1298858.AUEL01000012_gene5203	1.77e-12	71.2	COG3735@1|root,COG3735@2|Bacteria,1RBFT@1224|Proteobacteria,2U5YM@28211|Alphaproteobacteria,43I41@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	GumN family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_689141_2	1111732.AZOD01000016_gene214	1.43e-18	87.4	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1X3CZ@135614|Xanthomonadales	135614|Xanthomonadales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_819763_1	436308.Nmar_0518	6.41e-43	140.0	COG3277@1|root,arCOG02466@2157|Archaea,41SVG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	RNA-binding protein involved in rRNA processing	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
k59_819763_2	1229909.NSED_02600	1.44e-27	107.0	COG1405@1|root,arCOG01981@2157|Archaea,41S8Y@651137|Thaumarchaeota	651137|Thaumarchaeota	K	factor TFIIB	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k59_166622_1	933262.AXAM01000093_gene1591	1.28e-35	128.0	COG4887@1|root,COG4887@2|Bacteria,1RCNI@1224|Proteobacteria,43B8A@68525|delta/epsilon subdivisions,2WN0Y@28221|Deltaproteobacteria,2MNBY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1847)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1847
k59_721663_1	1545915.JROG01000004_gene2126	6.67e-32	127.0	COG1228@1|root,COG1228@2|Bacteria,1R40Z@1224|Proteobacteria,2U85Z@28211|Alphaproteobacteria,2KDVN@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_558537_1	471852.Tcur_4456	1.67e-62	200.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4EMMN@85012|Streptosporangiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_459997_1	314254.OA2633_01681	1.42e-48	163.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,43WJ8@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_459997_2	740709.A10D4_09534	3.58e-08	53.5	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,2QG23@267893|Idiomarinaceae	1236|Gammaproteobacteria	E	Histidine biosynthesis bifunctional protein HisIE	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186	PRA-CH,PRA-PH
k59_427624_1	710687.KI912270_gene2240	2.58e-18	87.8	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,235TR@1762|Mycobacteriaceae	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_884479_1	1007105.PT7_0061	4.39e-06	47.8	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria,3T3JR@506|Alcaligenaceae	28216|Betaproteobacteria	L	Belongs to the DnaA family	hda	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
k59_884479_2	497321.C664_13669	3.57e-68	216.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,2KVM3@206389|Rhodocyclales	206389|Rhodocyclales	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_329768_1	292415.Tbd_0019	8.22e-35	131.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,1KRMI@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2
k59_631125_7	399741.Spro_4945	1.16e-28	106.0	2E3AH@1|root,32YA0@2|Bacteria,1NBUZ@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1064)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1064
k59_631125_8	857293.CAAU_0781	8.29e-84	267.0	COG3723@1|root,COG3723@2|Bacteria,1UNDF@1239|Firmicutes,24ECD@186801|Clostridia,36HN4@31979|Clostridiaceae	186801|Clostridia	L	RecT family	-	-	-	ko:K07455	-	-	-	-	ko00000,ko03400	-	-	-	RecT
k59_631125_14	709032.Sulku_2622	1.94e-86	260.0	COG1961@1|root,COG1961@2|Bacteria,1RIV6@1224|Proteobacteria,42UK1@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	PFAM Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
k59_631125_15	1415778.JQMM01000001_gene30	4.95e-161	458.0	COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1RPM4@1236|Gammaproteobacteria,1J6YE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	C-5 cytosine-specific DNA methylase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
k59_466031_1	935261.JAGL01000079_gene1065	3.09e-51	176.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,43KZJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Transposase C of IS166 homeodomain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_141696_1	398767.Glov_2526	7.7e-20	85.9	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,43UAY@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1885	PdxJ
k59_141696_2	945713.IALB_2177	3.76e-70	219.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_369705_1	1123368.AUIS01000001_gene2001	1.98e-07	54.3	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,2NBR3@225057|Acidithiobacillales	225057|Acidithiobacillales	P	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_369705_2	1168034.FH5T_20250	8.14e-21	85.9	COG3829@1|root,COG3829@2|Bacteria,4NV2J@976|Bacteroidetes,2FTA0@200643|Bacteroidia	976|Bacteroidetes	KT	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9
k59_175445_1	1449351.RISW2_04865	1.55e-17	82.8	COG4604@1|root,COG4604@2|Bacteria,1QU78@1224|Proteobacteria,2TUJ3@28211|Alphaproteobacteria,4KNMD@93682|Roseivivax	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	ceuD	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_175445_2	883126.HMPREF9710_03123	5.56e-08	51.6	COG2076@1|root,COG2076@2|Bacteria,1MZ54@1224|Proteobacteria,2VU4A@28216|Betaproteobacteria,474UZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Small Multidrug Resistance protein	emrE	-	-	ko:K03297	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
k59_760720_1	388051.AUFE01000007_gene1446	4.69e-36	137.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,1K1H4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_760720_2	1485544.JQKP01000007_gene1951	3.48e-129	394.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,44VJV@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_466920_1	754477.Q7C_645	9.94e-49	166.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,45ZZF@72273|Thiotrichales	72273|Thiotrichales	S	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_272467_1	1007105.PT7_2623	8.51e-80	257.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,3T6UJ@506|Alcaligenaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF3394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_401758_1	580332.Slit_0530	1.5e-26	112.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria	28216|Betaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
k59_991003_1	999611.KI421504_gene3116	2.55e-12	71.2	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria,28079@191028|Leisingera	28211|Alphaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_991003_2	1454004.AW11_01098	6.04e-22	94.4	COG2176@1|root,COG5002@1|root,COG2176@2|Bacteria,COG5002@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria	28216|Betaproteobacteria	L	dna polymerase iii	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_892723_1	234267.Acid_5940	2.93e-19	90.9	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_401768_1	1323663.AROI01000020_gene671	2.2e-23	95.9	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	cell division ATP-binding protein FtsE	ftsE	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_632249_1	706587.Desti_1938	9.83e-104	319.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42Q3E@68525|delta/epsilon subdivisions,2WJCW@28221|Deltaproteobacteria,2MQV4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_272480_1	1288494.EBAPG3_7390	2.64e-108	322.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,372NZ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_338486_1	351348.Maqu_0966	1.26e-123	363.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,465C7@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_926635_1	1184609.KILIM_085_00150	2.34e-17	83.6	COG3836@1|root,COG3836@2|Bacteria,2HGEA@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_828780_1	1123393.KB891331_gene2911	3.87e-88	279.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,1KRI8@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_892740_1	448385.sce4315	2.74e-31	120.0	COG0811@1|root,COG0811@2|Bacteria,1RK2P@1224|Proteobacteria,42TPV@68525|delta/epsilon subdivisions,2X5KN@28221|Deltaproteobacteria,2YXI5@29|Myxococcales	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_892740_2	1254432.SCE1572_26065	0.000106	43.5	COG0848@1|root,COG0848@2|Bacteria,1N9DN@1224|Proteobacteria,42V0H@68525|delta/epsilon subdivisions,2WQGB@28221|Deltaproteobacteria,2Z0IY@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_401783_1	395494.Galf_1676	1.45e-10	62.8	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,44VIT@713636|Nitrosomonadales	28216|Betaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_632259_1	420324.KI911999_gene8064	1.27e-29	119.0	28JZZ@1|root,2Z9PZ@2|Bacteria,1N3C6@1224|Proteobacteria,2TSCX@28211|Alphaproteobacteria,1JTZB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_502271_1	1499967.BAYZ01000028_gene1283	3.83e-99	301.0	COG0065@1|root,COG0065@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0030312,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.3,4.2.1.33,4.2.1.35,4.2.1.85	ko:K01681,ko:K01703,ko:K17749,ko:K20452	ko00020,ko00290,ko00400,ko00630,ko00660,ko00720,ko00760,ko00966,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00400,map00630,map00660,map00720,map00760,map00966,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00432,M00535,M00740	R01324,R01325,R01900,R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170,R10501	RC00497,RC00498,RC00618,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iHN637.CLJU_RS04465,iPC815.YPO0531,iSB619.SA_RS10700	Aconitase
k59_567433_1	1424334.W822_01775	4.68e-43	150.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2VIJM@28216|Betaproteobacteria,3T5HA@506|Alcaligenaceae	28216|Betaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.77	ko:K01459	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_665479_1	2340.JV46_05690	2.85e-129	379.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_12483_1	595537.Varpa_1913	3.55e-10	64.3	COG1309@1|root,COG1309@2|Bacteria,1RHYT@1224|Proteobacteria,2VUI8@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator TetR	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
k59_142874_2	983917.RGE_42110	3.98e-77	231.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,1KKU5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	cheY-homologous receiver domain	pilG	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_760761_1	452637.Oter_1015	4.68e-111	334.0	COG2211@1|root,COG2211@2|Bacteria,46UGM@74201|Verrucomicrobia	74201|Verrucomicrobia	G	MFS/sugar transport protein	-	-	-	ko:K16211	-	-	-	-	ko00000,ko02000	2.A.2.6	-	-	MFS_1
k59_828801_1	1157708.KB907462_gene880	1.09e-44	150.0	COG3945@1|root,COG3945@2|Bacteria,1N12K@1224|Proteobacteria,2VUPY@28216|Betaproteobacteria,4AENF@80864|Comamonadaceae	28216|Betaproteobacteria	T	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_272488_2	1532558.JL39_11895	4.03e-08	53.5	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2TV26@28211|Alphaproteobacteria,4B7RY@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_370783_1	1144319.PMI16_00951	5.16e-148	431.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,473DJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	AAA-like domain	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_142887_1	945713.IALB_0635	3.22e-99	313.0	COG0178@1|root,COG0178@2|Bacteria	2|Bacteria	L	nucleotide-excision repair	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_698305_1	748247.AZKH_1968	7.14e-59	203.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,2KVRF@206389|Rhodocyclales	206389|Rhodocyclales	S	exporters of the RND superfamily	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_110203_1	105559.Nwat_2073	3.89e-68	217.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WZ4R@135613|Chromatiales	135613|Chromatiales	BQ	PFAM histone deacetylase superfamily	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_1017953_1	864051.BurJ1DRAFT_4157	1.53e-124	364.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,1KJVF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_44816_1	330214.NIDE1871	8.07e-90	269.0	COG0689@1|root,COG0689@2|Bacteria,3J0B8@40117|Nitrospirae	40117|Nitrospirae	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_959200_2	7070.TC006914-PA	1.16e-38	147.0	2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,41XP3@6656|Arthropoda,3SQBU@50557|Insecta	33208|Metazoa	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2,Endonuclease_7
k59_860544_1	910964.GEAM_3585	2.46e-31	116.0	COG0454@1|root,COG0456@2|Bacteria,1N6BV@1224|Proteobacteria,1SAMT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_567463_1	269796.Rru_A1016	5.64e-101	303.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2TSFD@28211|Alphaproteobacteria,2JQTE@204441|Rhodospirillales	204441|Rhodospirillales	E	Putrescine transport system permease	potH	-	-	ko:K11075	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	BPD_transp_1
k59_305143_1	1499967.BAYZ01000185_gene4523	1.5e-67	221.0	COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria	2|Bacteria	S	Amidohydrolase family	ytcJ	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_272499_1	1121035.AUCH01000009_gene813	3.94e-84	262.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,2KU9H@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_760783_1	439235.Dalk_3994	8.95e-20	94.7	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,42U8I@68525|delta/epsilon subdivisions,2WQCY@28221|Deltaproteobacteria,2MNWM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_436093_1	864051.BurJ1DRAFT_3964	8.73e-90	273.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2VKXM@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_44845_1	864051.BurJ1DRAFT_2712	1.01e-96	295.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,1KJV6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_436099_1	323848.Nmul_A1403	2.32e-124	375.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VJDX@28216|Betaproteobacteria,37407@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Domain of unknown function (DUF3459)	treZ	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_892807_1	439496.RBY4I_732	4.57e-34	135.0	COG2931@1|root,COG5549@1|root,COG2931@2|Bacteria,COG5549@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,HemolysinCabind,Reprolysin_4
k59_959235_1	266117.Rxyl_0314	9.51e-48	171.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4CP80@84995|Rubrobacteria	84995|Rubrobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_238565_2	555779.Dthio_PD3053	8.09e-16	72.4	COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,42WU5@68525|delta/epsilon subdivisions,2WSUR@28221|Deltaproteobacteria,2ME4G@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
k59_238565_3	883.DvMF_2382	3.37e-12	65.5	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2M9IV@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_401843_1	748247.AZKH_2251	8.15e-92	294.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,2KV2V@206389|Rhodocyclales	206389|Rhodocyclales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_436103_1	330214.NIDE4234	1.89e-122	355.0	COG0284@1|root,COG0284@2|Bacteria,3J0SC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_467032_1	1454004.AW11_01612	7.73e-28	110.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,1KQ8B@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Peptidase family M50	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_467032_2	640081.Dsui_2686	2.15e-53	186.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales	206389|Rhodocyclales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_828872_1	519989.ECTPHS_07791	1.52e-53	186.0	COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,1RNHS@1236|Gammaproteobacteria,1X2DE@135613|Chromatiales	135613|Chromatiales	F	Ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,LAGLIDADG_3,NRDD
k59_110256_1	1265505.ATUG01000002_gene2071	3.21e-55	180.0	29GM5@1|root,303IT@2|Bacteria,1RG3T@1224|Proteobacteria,42RUX@68525|delta/epsilon subdivisions,2WNMJ@28221|Deltaproteobacteria,2MJY1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_768055_1	323848.Nmul_A0502	5.09e-89	273.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,3723P@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,S4_2,tRNA-synt_1b
k59_640643_1	330214.NIDE3315	3.78e-61	199.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Cu_amine_oxidN1,F5_F8_type_C,IgGFc_binding,PKD
k59_707077_1	330214.NIDE4079	6.23e-63	210.0	COG2274@1|root,COG2274@2|Bacteria	2|Bacteria	V	protein secretion by the type I secretion system	-	-	-	ko:K02021	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_640644_1	395495.Lcho_3744	4.35e-86	280.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KJIC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_346941_1	365659.smi_0596	5.36e-13	72.8	COG3547@1|root,COG3547@2|Bacteria,1VX5K@1239|Firmicutes,4I4PZ@91061|Bacilli,2TQDR@28037|Streptococcus mitis	91061|Bacilli	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_20
k59_608314_1	292415.Tbd_0928	9.97e-131	375.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,1KTIC@119069|Hydrogenophilales	119069|Hydrogenophilales	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_378894_1	1122207.MUS1_01085	3.32e-15	79.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,1RSC6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_216118_1	556268.OFAG_00241	2.96e-117	343.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2VGZK@28216|Betaproteobacteria,472XW@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_21079_1	177437.HRM2_23070	6.21e-08	51.6	2EIY1@1|root,33CP7@2|Bacteria,1NIFZ@1224|Proteobacteria,42XDK@68525|delta/epsilon subdivisions,2WTBK@28221|Deltaproteobacteria,2MM9X@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_21079_2	357808.RoseRS_2302	1.22e-40	143.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi,37631@32061|Chloroflexia	32061|Chloroflexia	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_53016_1	562970.Btus_1824	1.08e-87	270.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,4H9PW@91061|Bacilli,2784U@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08945	DHBP_synthase,GTP_cyclohydro2
k59_378898_1	331113.SNE_A20240	8.23e-57	189.0	COG0686@1|root,COG0686@2|Bacteria,2JFCH@204428|Chlamydiae	204428|Chlamydiae	C	Alanine dehydrogenase/PNT, N-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_216122_1	765912.Thimo_3047	9.21e-91	283.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales	135613|Chromatiales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_245710_1	1131814.JAFO01000001_gene4131	6.15e-34	129.0	COG0372@1|root,COG0372@2|Bacteria,1MUII@1224|Proteobacteria,2TSDI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	citrate synthase	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_576118_1	987059.RBXJA2T_11648	4.1e-98	289.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria,1KJ0X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_576118_2	1286631.X805_32040	3.19e-21	92.4	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,1KK5E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_444273_1	945713.IALB_2290	5.68e-49	160.0	2AQ71@1|root,31FCR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_408987_1	56780.SYN_01091	4.31e-30	118.0	COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria,2MQZY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Cation transport protein	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_408987_2	1121405.dsmv_0675	5.93e-40	145.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2MJ0H@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_935375_1	1038869.AXAN01000188_gene5591	5.56e-15	75.5	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1K2WH@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k59_935375_2	396595.TK90_1017	1.23e-18	87.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WXH8@135613|Chromatiales	135613|Chromatiales	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
k59_674343_1	37659.JNLN01000001_gene1994	1.19e-33	133.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1TQXZ@1239|Firmicutes,249E6@186801|Clostridia,36DCZ@31979|Clostridiaceae	186801|Clostridia	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	BatA,GATase1_like,VWA,VWA_2,VWA_3
k59_768102_1	83406.HDN1F_21760	4.9e-28	109.0	COG3063@1|root,COG3063@2|Bacteria,1RAFJ@1224|Proteobacteria,1S5H6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Pilus assembly protein	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_12,TPR_16,TPR_19,TPR_2,TPR_8
k59_790830_1	565045.NOR51B_1324	6.56e-91	285.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_346975_1	658187.LDG_6140	1.75e-104	319.0	COG3464@1|root,COG3464@2|Bacteria,1QC9Y@1224|Proteobacteria,1T7ZK@1236|Gammaproteobacteria,1JG2Q@118969|Legionellales	118969|Legionellales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_869040_2	1123368.AUIS01000031_gene1418	1.09e-62	202.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,1T8C8@1236|Gammaproteobacteria,2NCKI@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_276735_1	570967.JMLV01000001_gene2804	1.92e-53	186.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,2JPAU@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_968015_2	335543.Sfum_3496	4.47e-58	193.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2X5CN@28221|Deltaproteobacteria,2MRN0@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	TOBE domain	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_674361_1	933262.AXAM01000022_gene3241	2.15e-84	278.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_900720_1	314231.FP2506_16854	7.97e-62	201.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_576151_1	1229909.NSED_08025	6.24e-79	241.0	COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
k59_409019_1	1232410.KI421426_gene1474	1.61e-59	201.0	COG3264@1|root,COG3264@2|Bacteria,1QUDC@1224|Proteobacteria,43DHA@68525|delta/epsilon subdivisions,2X8P3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_608360_1	1120968.AUBX01000016_gene1808	1.48e-14	79.0	COG2373@1|root,COG2373@2|Bacteria,4NGYZ@976|Bacteroidetes	976|Bacteroidetes	S	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_707157_1	1562701.BBOF01000067_gene2052	2.41e-46	155.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2VSEP@28216|Betaproteobacteria,1K1IQ@119060|Burkholderiaceae	28216|Betaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
k59_216167_1	85643.Tmz1t_2674	7.73e-42	148.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,2KUUD@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_276744_1	404589.Anae109_0696	3.62e-11	70.5	COG0457@1|root,COG3170@1|root,COG0457@2|Bacteria,COG3170@2|Bacteria,1R7RK@1224|Proteobacteria,42PPY@68525|delta/epsilon subdivisions,2WKX6@28221|Deltaproteobacteria,2YUCP@29|Myxococcales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19
k59_276744_2	717231.Flexsi_1857	0.000231	43.9	COG1052@1|root,COG1052@2|Bacteria,2GEPS@200930|Deferribacteres	200930|Deferribacteres	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_707164_1	1123367.C666_10755	6.88e-83	269.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KVJC@206389|Rhodocyclales	206389|Rhodocyclales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_576170_1	1469245.JFBG01000074_gene98	1.38e-60	199.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales	135613|Chromatiales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_576170_2	472759.Nhal_3844	7.7e-07	50.1	COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria,1S423@1236|Gammaproteobacteria,1WWQ9@135613|Chromatiales	135613|Chromatiales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
k59_837706_1	504832.OCAR_7524	2.01e-80	248.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRS8@28211|Alphaproteobacteria,3JS1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	nikB	-	-	ko:K02033,ko:K15585	ko02010,ko02024,map02010,map02024	M00239,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_640716_1	1283284.AZUK01000001_gene787	1.59e-36	140.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1Y51C@135624|Aeromonadales	1236|Gammaproteobacteria	NU	Neisseria PilC beta-propeller domain	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
k59_118822_1	296591.Bpro_3216	9.17e-64	205.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VKXZ@28216|Betaproteobacteria,4A9K4@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily	phnW	-	2.6.1.37	ko:K03430	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R04152	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_5
k59_118822_2	296591.Bpro_3217	7.01e-20	89.4	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2VI17@28216|Betaproteobacteria,4ACCU@80864|Comamonadaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_183833_2	1123499.KB908025_gene1504	1.53e-55	184.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,2KQ7Q@206351|Neisseriales	206351|Neisseriales	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
k59_118825_1	1528106.JRJE01000031_gene3353	5.33e-73	229.0	COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,2TU6M@28211|Alphaproteobacteria,2JRRQ@204441|Rhodospirillales	204441|Rhodospirillales	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_576185_1	999541.bgla_1g26410	1.38e-66	219.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,1K27M@119060|Burkholderiaceae	28216|Betaproteobacteria	E	gamma-glutamyltransferase	ggt1	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_444339_1	519989.ECTPHS_05085	5.63e-65	205.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1S1PR@1236|Gammaproteobacteria,1WY6G@135613|Chromatiales	135613|Chromatiales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_444339_2	338963.Pcar_2751	1.78e-11	64.3	COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,42SPY@68525|delta/epsilon subdivisions,2WP3D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_739642_1	667632.KB890173_gene3882	2.77e-44	152.0	COG1309@1|root,COG1309@2|Bacteria,1N659@1224|Proteobacteria,2VS47@28216|Betaproteobacteria,1K29V@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	acrR	-	-	ko:K03577	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	TetR_C_2,TetR_N
k59_118831_1	696281.Desru_2408	6.28e-28	110.0	COG4303@1|root,COG4303@2|Bacteria,1TP15@1239|Firmicutes,248P5@186801|Clostridia,260JB@186807|Peptococcaceae	186801|Clostridia	E	PFAM Ethanolamine ammonia lyase large subunit	eutB	-	4.3.1.7	ko:K03735	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutB
k59_118831_2	1144342.PMI40_01289	1.35e-08	61.2	COG4302@1|root,COG4302@2|Bacteria,1MWQI@1224|Proteobacteria,2VJ8Y@28216|Betaproteobacteria,473X3@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Belongs to the EutC family	eutC	-	4.3.1.7	ko:K03736	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutC
k59_21162_1	641491.DND132_2614	4.56e-46	164.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_53102_1	1121035.AUCH01000001_gene1902	2.49e-25	105.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,2KUYX@206389|Rhodocyclales	206389|Rhodocyclales	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_640740_2	1502770.JQMG01000001_gene457	6.45e-09	56.2	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,2KME5@206350|Nitrosomonadales	206350|Nitrosomonadales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_768165_1	243159.AFE_2600	2.1e-30	108.0	COG0425@1|root,COG0425@2|Bacteria,1NDVB@1224|Proteobacteria,1T176@1236|Gammaproteobacteria,2ND8U@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
k59_151499_1	1286631.X805_40950	1.73e-132	389.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,1KIWD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_968079_1	999141.GME_08534	4.5e-57	197.0	COG0524@1|root,COG3892@1|root,COG0524@2|Bacteria,COG3892@2|Bacteria,1MV6I@1224|Proteobacteria,1RQGH@1236|Gammaproteobacteria,1XIYQ@135619|Oceanospirillales	135619|Oceanospirillales	G	5-dehydro-2-deoxygluconokinase	-	-	2.7.1.92	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R05661	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DUF2090,PfkB
k59_347047_1	1538295.JY96_13095	1.34e-45	155.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,1KJQ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	cyc	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_347047_2	1454004.AW11_00143	1.89e-09	57.8	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2VIKF@28216|Betaproteobacteria,1KQ2M@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_739666_1	159087.Daro_0962	3.02e-119	356.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,2KUBM@206389|Rhodocyclales	206389|Rhodocyclales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_837752_1	1131553.JIBI01000021_gene263	7.9e-82	258.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,371U0@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_576216_1	977880.RALTA_A1983	1.18e-110	348.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1K2N9@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_935469_1	365044.Pnap_1064	3.22e-76	251.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,4ABDP@80864|Comamonadaceae	28216|Betaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_739676_1	452637.Oter_1514	1.66e-36	129.0	COG1136@1|root,COG1136@2|Bacteria,46YZ8@74201|Verrucomicrobia,3K9FX@414999|Opitutae	414999|Opitutae	P	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_768989_1	859657.RPSI07_1651	1.04e-93	286.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,1K1VP@119060|Burkholderiaceae	28216|Betaproteobacteria	E	o-acetylhomoserine	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_708162_1	926569.ANT_06310	5.42e-49	167.0	COG1134@1|root,COG1134@2|Bacteria	2|Bacteria	GM	teichoic acid transport	-	-	3.6.3.38	ko:K01990,ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
k59_313801_1	696747.NIES39_G01010	9.96e-17	80.5	COG3415@1|root,COG3415@2|Bacteria,1G7ZW@1117|Cyanobacteria,1HB54@1150|Oscillatoriales	1117|Cyanobacteria	L	Winged helix-turn helix	-	-	-	ko:K07499	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_28,HTH_29,HTH_32
k59_347962_1	880073.Calab_1953	9.24e-37	135.0	COG0579@1|root,COG0579@2|Bacteria,2NPCR@2323|unclassified Bacteria	2|Bacteria	C	FAD dependent oxidoreductase	lhgO	-	1.1.99.2	ko:K00109,ko:K15736	ko00650,map00650	-	R03534	RC00031	ko00000,ko00001,ko01000	-	-	-	DAO
k59_347962_2	1499967.BAYZ01000194_gene3120	7.71e-36	126.0	COG2905@1|root,COG2905@2|Bacteria,2NQ7R@2323|unclassified Bacteria	2|Bacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_641673_1	1129374.AJE_05231	2.96e-76	249.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,1RQIV@1236|Gammaproteobacteria,466HD@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Protein of unknown function (DUF3300)	yacH	-	-	-	-	-	-	-	-	-	-	-	DUF3300
k59_675398_1	436308.Nmar_1589	6.21e-27	99.8	arCOG10591@1|root,arCOG10591@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_159580_1	1124780.ANNU01000038_gene206	1.64e-28	118.0	COG1629@1|root,COG1629@2|Bacteria,4P4MW@976|Bacteroidetes,47JAS@768503|Cytophagia	976|Bacteroidetes	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug
k59_794072_1	522306.CAP2UW1_1545	2.06e-41	150.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1KQED@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	degQ	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_748141_1	1459636.NTE_03484	3.25e-150	434.0	COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_252942_1	292.DM42_1677	3.64e-68	222.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,1K1JD@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_252942_2	582744.Msip34_2816	1.58e-130	378.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,2KKJZ@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_386624_1	1223410.KN050846_gene566	3.18e-08	61.6	COG2815@1|root,COG2815@2|Bacteria,4NXFG@976|Bacteroidetes,1I6HM@117743|Flavobacteriia	976|Bacteroidetes	S	TIR domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	TIR_2
k59_29324_1	1049564.TevJSym_bb00050	1.68e-89	283.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_846321_1	404589.Anae109_0418	8.7e-43	152.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria,2YVQ5@29|Myxococcales	28221|Deltaproteobacteria	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_452204_1	289376.THEYE_A0559	9.24e-90	275.0	COG0777@1|root,COG0777@2|Bacteria,3J0CK@40117|Nitrospirae	40117|Nitrospirae	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1007318_1	1125863.JAFN01000001_gene1861	4.45e-81	255.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42N74@68525|delta/epsilon subdivisions,2WKUN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	extracellular solute-binding protein, family 5	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_846328_1	42256.RradSPS_1314	7.77e-63	212.0	COG3960@1|root,COG3960@2|Bacteria,2GJY3@201174|Actinobacteria,4CU2P@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the TPP enzyme family	-	-	4.1.1.47	ko:K01608	ko00630,ko01100,map00630,map01100	-	R00013	RC00899	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_616520_1	713586.KB900536_gene2234	1.32e-79	259.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_616520_2	1260251.SPISAL_00265	4.28e-07	50.1	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales	135613|Chromatiales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
k59_320391_2	1231391.AMZF01000009_gene1749	6.58e-72	225.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VJJU@28216|Betaproteobacteria,3T8WN@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_748163_1	1461693.ATO10_15300	1e-25	110.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_908642_1	330214.NIDE4377	1.68e-37	138.0	COG0488@1|root,COG0488@2|Bacteria,3J0WR@40117|Nitrospirae	40117|Nitrospirae	S	ABC transporter	-	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
k59_519383_1	448385.sce9162	6.01e-56	191.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,430KD@68525|delta/epsilon subdivisions,2WVSS@28221|Deltaproteobacteria,2YZ09@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
k59_748172_2	204669.Acid345_1213	9.86e-28	111.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria,2JIRS@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_386653_1	1000565.METUNv1_02910	8.14e-59	188.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,2KUPA@206389|Rhodocyclales	206389|Rhodocyclales	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_386653_2	522306.CAP2UW1_2740	3.58e-19	82.4	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE8	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_224121_1	497321.C664_02750	6.03e-106	319.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,2KUMC@206389|Rhodocyclales	206389|Rhodocyclales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_943880_1	671143.DAMO_2072	1.01e-59	207.0	COG1075@1|root,COG4995@1|root,COG1075@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TPR_12
k59_715678_1	316055.RPE_4485	1.09e-31	121.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,2U26E@28211|Alphaproteobacteria,3K2QG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_715678_2	1449350.OCH239_20365	1.03e-44	155.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_943881_1	1366050.N234_27780	2.62e-54	184.0	COG5380@1|root,COG5380@2|Bacteria,1N6UY@1224|Proteobacteria,2VRU4@28216|Betaproteobacteria,1K5X7@119060|Burkholderiaceae	28216|Betaproteobacteria	O	lipid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_126998_1	1229909.NSED_05700	1.19e-25	99.0	COG2236@1|root,arCOG00040@2157|Archaea,41TA1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	phosphoribosyltransferase	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	-
k59_252979_2	1120999.JONM01000008_gene2006	4.78e-29	111.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,2KSUN@206351|Neisseriales	206351|Neisseriales	KT	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_29369_1	360910.BAV0452	2.79e-93	288.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,3T1HR@506|Alcaligenaceae	28216|Betaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_877174_1	1121918.ARWE01000001_gene2821	1.26e-104	314.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42N83@68525|delta/epsilon subdivisions,2WJFF@28221|Deltaproteobacteria,43T0V@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_224130_1	1411123.JQNH01000001_gene3814	4.29e-20	88.2	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TV99@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the citrate synthase family	prpC	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_224130_2	1408164.MOLA814_01208	1.88e-09	60.8	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2VKPZ@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_481176_1	1121920.AUAU01000020_gene2550	5.14e-80	252.0	COG0433@1|root,COG0433@2|Bacteria,3Y69X@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	-	-	-	-	-	-	-	-	-	DUF853
k59_355312_1	1288494.EBAPG3_25940	3.25e-81	254.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,372X1@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	Sugar (and other) transporter	yajR	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_191738_1	640081.Dsui_0298	1.85e-101	305.0	COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,2VI48@28216|Betaproteobacteria,2KXHY@206389|Rhodocyclales	206389|Rhodocyclales	J	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
k59_320427_1	1288494.EBAPG3_26760	2.72e-121	362.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,371ZV@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_416315_1	269482.Bcep1808_3694	2.54e-39	145.0	COG0526@1|root,COG0526@2|Bacteria,1MWU8@1224|Proteobacteria,2VPNK@28216|Betaproteobacteria,1K2PC@119060|Burkholderiaceae	28216|Betaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2,Thioredoxin_7
k59_616573_1	945713.IALB_2016	2.59e-97	295.0	COG0389@1|root,COG0389@2|Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_976722_1	1229909.NSED_08130	8.1e-47	167.0	COG1012@1|root,arCOG01252@2157|Archaea,41T12@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_416318_2	582744.Msip34_0722	9.04e-26	108.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,2KM1R@206350|Nitrosomonadales	206350|Nitrosomonadales	J	TIGRFAM phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_715722_1	945713.IALB_0712	2.09e-29	113.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,DUF1460
k59_715722_2	1191523.MROS_1701	4.21e-15	75.1	COG1091@1|root,COG1091@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose reductase activity	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_452277_1	1348114.OM33_16930	1.03e-47	174.0	COG1215@1|root,COG1215@2|Bacteria,1R18D@1224|Proteobacteria,1T4WJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Bacterial cellulose synthase subunit	-	-	-	ko:K20541	-	-	-	-	ko00000,ko02000	4.D.3.1.6	-	-	BcsB
k59_1026310_1	1366050.N234_10650	1.04e-24	106.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VM0F@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_481196_1	349521.HCH_03588	8.94e-33	134.0	COG0745@1|root,COG0784@1|root,COG5000@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,CHASE3,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_715725_1	987059.RBXJA2T_12157	6.61e-125	377.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,1KIW8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	RNB	rnb	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
k59_355340_1	583355.Caka_0018	1.1e-62	217.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,46S66@74201|Verrucomicrobia,3K7GM@414999|Opitutae	414999|Opitutae	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
k59_775580_1	1232410.KI421428_gene1220	6.92e-106	309.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2WJ1Z@28221|Deltaproteobacteria,43T6A@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_95127_1	617140.AJZE01000101_gene3102	1.21e-32	120.0	2E4R1@1|root,32ZJK@2|Bacteria,1N8FZ@1224|Proteobacteria,1SAJ2@1236|Gammaproteobacteria,1XXUY@135623|Vibrionales	135623|Vibrionales	S	Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
k59_95127_2	358220.C380_20080	4.4e-05	45.4	COG3597@1|root,COG3597@2|Bacteria,1QG9J@1224|Proteobacteria,2VIRR@28216|Betaproteobacteria,4AATU@80864|Comamonadaceae	28216|Betaproteobacteria	P	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	DUF533,TerB
k59_846412_1	2002.JOEQ01000023_gene1210	2.63e-20	96.3	COG0477@1|root,COG1020@1|root,COG0477@2|Bacteria,COG1020@2|Bacteria,2H43Q@201174|Actinobacteria,4EN5B@85012|Streptosporangiales	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related protein-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,MFS_1,PP-binding,Thioesterase
k59_616597_1	1158150.KB906241_gene1253	3.91e-08	58.5	COG4648@1|root,COG4648@2|Bacteria,1NCP1@1224|Proteobacteria,1SEHE@1236|Gammaproteobacteria,1WZPK@135613|Chromatiales	135613|Chromatiales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_355351_1	269799.Gmet_0177	1.72e-21	99.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42YF8@68525|delta/epsilon subdivisions,2WU6H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA-3	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_584929_1	977880.RALTA_A0243	5.05e-67	212.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2VJ8M@28216|Betaproteobacteria,1K1NE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
k59_584929_2	568706.BN118_1180	2.88e-45	155.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VI3G@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit is responsible for energy coupling to the transport system	nodI	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
k59_683032_1	105559.Nwat_0059	2.31e-101	333.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_908710_1	316067.Geob_1840	4.98e-24	96.3	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,43BI9@68525|delta/epsilon subdivisions,2X6WN@28221|Deltaproteobacteria,43U6T@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_908710_2	929556.Solca_0144	1.33e-17	81.6	COG3571@1|root,COG3571@2|Bacteria,4NEGG@976|Bacteroidetes,1IUJ8@117747|Sphingobacteriia	976|Bacteroidetes	S	Alpha/beta hydrolase family	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_5
k59_715741_1	1229909.NSED_00255	2.2e-77	232.0	COG0432@1|root,arCOG04214@2157|Archaea,41T31@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_715741_2	436308.Nmar_0110	1.73e-41	139.0	arCOG08723@1|root,arCOG08723@2157|Archaea,41SPX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_355358_1	96561.Dole_1488	5.94e-07	50.4	COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria,2MIKC@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
k59_355358_2	177437.HRM2_28820	4.52e-50	168.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MJIG@213118|Desulfobacterales	28221|Deltaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_29428_1	95619.PM1_0226030	1.56e-18	84.3	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	(ABC) transporter	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_29428_2	344747.PM8797T_24521	8.12e-12	67.0	2ECB1@1|root,3369C@2|Bacteria,2J4U8@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1026322_1	1037409.BJ6T_23810	2.49e-134	393.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,3JSHP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_877219_1	102125.Xen7305DRAFT_00020060	0.000873	52.4	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CW_binding_1,VCBS
k59_648903_1	653733.Selin_1987	1.48e-28	108.0	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_683048_1	1266914.ATUK01000013_gene1979	1.72e-85	274.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_649980_1	1229909.NSED_05055	7.06e-60	187.0	arCOG08684@1|root,arCOG08684@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_649980_2	1229909.NSED_08230	2.59e-39	140.0	arCOG08642@1|root,arCOG08642@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_520606_1	1042209.HK44_021515	1.15e-06	54.7	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_520606_2	983920.Y88_1815	9.47e-12	65.1	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,2K085@204457|Sphingomonadales	204457|Sphingomonadales	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
k59_776650_1	879212.DespoDRAFT_01512	1.43e-40	140.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WJX8@28221|Deltaproteobacteria,2MJAF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	ehrS	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2596	Fer4,Fer4_7,Oxidored_q6
k59_776650_2	526222.Desal_3509	2.19e-24	102.0	COG0663@1|root,COG0663@2|Bacteria,1N42I@1224|Proteobacteria,42NWC@68525|delta/epsilon subdivisions,2WIYQ@28221|Deltaproteobacteria,2M93V@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_321456_1	566466.NOR53_2087	9.87e-102	310.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RYI9@1236|Gammaproteobacteria,1J9PP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_30546_1	306281.AJLK01000189_gene1817	1.31e-11	66.6	COG0466@1|root,COG0466@2|Bacteria,1G3NF@1117|Cyanobacteria	1117|Cyanobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	-	-	-	-	-	-	-	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_30546_2	1040989.AWZU01000009_gene1157	0.000283	45.8	COG0745@1|root,COG0745@2|Bacteria,1NBC8@1224|Proteobacteria,2U0UQ@28211|Alphaproteobacteria,3JTV8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	virG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_847614_1	1485544.JQKP01000018_gene571	5.12e-61	200.0	COG1819@1|root,COG1819@2|Bacteria,1MVJM@1224|Proteobacteria,2VME8@28216|Betaproteobacteria,44V3H@713636|Nitrosomonadales	28216|Betaproteobacteria	CG	glycosyl	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_847614_2	880070.Cycma_2501	3.71e-32	118.0	COG0589@1|root,COG0589@2|Bacteria,4NNMW@976|Bacteroidetes,47UY4@768503|Cytophagia	976|Bacteroidetes	T	COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_649991_1	1502770.JQMG01000001_gene1332	4.1e-53	173.0	COG3832@1|root,COG3832@2|Bacteria,1QZAY@1224|Proteobacteria	1224|Proteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_160811_1	331869.BAL199_25144	4.53e-54	181.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2TQXZ@28211|Alphaproteobacteria,4BQ5E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_96291_1	1131553.JIBI01000011_gene721	1.08e-73	224.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2VR9P@28216|Betaproteobacteria,3732R@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_716910_1	1485544.JQKP01000003_gene265	8.46e-109	320.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,44VM7@713636|Nitrosomonadales	28216|Betaproteobacteria	M	DAHP synthetase I family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_295394_1	1123393.KB891327_gene374	6.41e-82	251.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,1KRM4@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	-	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_621967_1	1232410.KI421414_gene2842	1.6e-94	286.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,43T3I@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_360569_1	1288494.EBAPG3_13360	1.25e-84	268.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,372U6@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Orn/Lys/Arg decarboxylase, C-terminal domain	-	-	4.1.1.19	ko:K01583	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
k59_99547_1	1232410.KI421412_gene332	1.54e-62	198.0	COG3155@1|root,COG3155@2|Bacteria,1MW2K@1224|Proteobacteria,42R54@68525|delta/epsilon subdivisions,2WMNZ@28221|Deltaproteobacteria,43SYS@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	DJ-1/PfpI family	elbB	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
k59_621973_1	485913.Krac_8942	1.88e-26	108.0	COG2141@1|root,COG2141@2|Bacteria,2G8CA@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_752253_1	339670.Bamb_0143	8.55e-80	249.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,1K5SS@119060|Burkholderiaceae	28216|Betaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.59	ko:K02805	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_328057_1	1266925.JHVX01000018_gene1814	1.18e-34	120.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2VU2G@28216|Betaproteobacteria,373HA@32003|Nitrosomonadales	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_328057_2	1424334.W822_05385	7.09e-18	76.6	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2VVNT@28216|Betaproteobacteria,3T4QD@506|Alcaligenaceae	28216|Betaproteobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_948370_1	1123368.AUIS01000007_gene2782	4.94e-81	248.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,1SHQ0@1236|Gammaproteobacteria,2NBRI@225057|Acidithiobacillales	225057|Acidithiobacillales	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17
k59_948370_2	765914.ThisiDRAFT_1534	2.97e-12	65.1	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_589325_2	880072.Desac_1765	1.01e-35	130.0	COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria	1224|Proteobacteria	M	Acetyltransferase (GNAT) domain	MA20_16670	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_164889_1	748247.AZKH_1952	3e-74	231.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2VJ9I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_980965_1	1041146.ATZB01000112_gene3782	1.7e-95	288.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,4BA6V@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_524046_1	497321.C664_05606	6.78e-107	325.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2VRA9@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_132299_1	926569.ANT_29200	1.98e-61	211.0	COG4412@1|root,COG4412@2|Bacteria,2G622@200795|Chloroflexi	200795|Chloroflexi	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
k59_67025_1	1121875.KB907553_gene20	1.65e-71	230.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_67030_1	1040987.AZUY01000072_gene1504	2.79e-82	246.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria	1224|Proteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,rve,rve_3
k59_328098_1	518766.Rmar_2279	2.07e-49	164.0	COG3090@1|root,COG3090@2|Bacteria,4NNRW@976|Bacteroidetes	976|Bacteroidetes	G	TRAP-type C4-dicarboxylate transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_328098_2	1121931.AUHG01000010_gene447	5.58e-14	72.0	COG1638@1|root,COG1638@2|Bacteria,4NGV4@976|Bacteroidetes,1HZ02@117743|Flavobacteriia	976|Bacteroidetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_524053_1	580332.Slit_2233	5.61e-19	86.7	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,44UYD@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_524053_2	935866.JAER01000003_gene1208	1.21e-17	85.5	2DM04@1|root,3139Z@2|Bacteria,2IBU0@201174|Actinobacteria,4DQKU@85009|Propionibacteriales	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_589359_1	948106.AWZT01000016_gene204	1.67e-42	146.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,2VK31@28216|Betaproteobacteria,1K0XM@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Nitrate reductase	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
k59_589359_2	1192868.CAIU01000009_gene1209	7.55e-36	130.0	COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,2U3I3@28211|Alphaproteobacteria,43M1J@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
k59_262930_1	568706.BN118_0616	3.17e-57	195.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2VKAQ@28216|Betaproteobacteria,3T8XH@506|Alcaligenaceae	28216|Betaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_164925_1	1509405.GV67_06560	4.84e-78	244.0	COG1840@1|root,COG1840@2|Bacteria,1Q13Q@1224|Proteobacteria,2TS7Y@28211|Alphaproteobacteria,4B8Z6@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6
k59_622013_1	1288494.EBAPG3_2720	8.16e-110	343.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,372B8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_850369_1	261292.Nit79A3_1064	3.45e-67	209.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,2VITY@28216|Betaproteobacteria,372XK@32003|Nitrosomonadales	28216|Betaproteobacteria	U	MotA TolQ ExbB proton channel	exbB2	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_230072_1	498761.HM1_1431	4.51e-90	278.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia	186801|Clostridia	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_34376_1	335543.Sfum_0443	1.61e-50	170.0	COG3218@1|root,COG3218@2|Bacteria,1QWQA@1224|Proteobacteria,42VJ7@68525|delta/epsilon subdivisions,2WS0Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
k59_295453_1	1304885.AUEY01000006_gene718	3.99e-101	320.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2MIFX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
k59_230078_1	265072.Mfla_0392	1.29e-50	171.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,2KKR6@206350|Nitrosomonadales	206350|Nitrosomonadales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_230078_2	95619.PM1_0221165	5.21e-08	53.5	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_654770_1	580332.Slit_1178	2.82e-83	261.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,44V74@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_818042_1	335659.S23_59300	3.6e-15	80.5	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria,3JRMI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	MA20_04810	-	3.5.1.82	ko:K01461	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_3
k59_164942_1	987059.RBXJA2T_17162	2.05e-103	317.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,1KJ66@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_980996_2	557598.LHK_00704	7.8e-113	328.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VIJC@28216|Betaproteobacteria,2KPI7@206351|Neisseriales	206351|Neisseriales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_980996_3	1163617.SCD_n00875	1e-181	514.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria	28216|Betaproteobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_393304_2	6087.XP_002169158.2	1.94e-42	153.0	2D12R@1|root,2SGHE@2759|Eukaryota,3AD4C@33154|Opisthokonta,3C0QR@33208|Metazoa	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Pox_A32
k59_230101_1	232348.ADXL01000091_gene455	1.87e-26	110.0	COG2801@1|root,COG2801@2|Bacteria,1G5RM@1117|Cyanobacteria,1GZMX@1129|Synechococcus	1117|Cyanobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k59_687437_1	1449353.JQMQ01000004_gene5931	1.18e-85	265.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,2NESD@228398|Streptacidiphilus	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
k59_948433_1	497965.Cyan7822_2491	1.63e-78	250.0	COG0033@1|root,COG0033@2|Bacteria,1G4TU@1117|Cyanobacteria,3KJFW@43988|Cyanothece	1117|Cyanobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.pgm	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_491587_1	640510.BC1001_0255	4.82e-58	187.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,1K0UQ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	PFAM UBA THIF-type NAD FAD binding protein	thiF	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_132350_1	338963.Pcar_2069	3.12e-40	142.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,42QRZ@68525|delta/epsilon subdivisions,2WMZS@28221|Deltaproteobacteria,43SGM@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_752324_1	1382356.JQMP01000001_gene1147	2.73e-87	272.0	COG0683@1|root,COG0683@2|Bacteria,2G7TX@200795|Chloroflexi,27YY0@189775|Thermomicrobia	189775|Thermomicrobia	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_132355_1	83406.HDN1F_35820	7.99e-08	53.5	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1J4N8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component	ybbP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_132355_2	1116472.MGMO_175c00090	1.93e-59	190.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1XE9K@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_491592_1	395494.Galf_0315	1.84e-53	187.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,44V3U@713636|Nitrosomonadales	28216|Betaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K02021,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_981023_1	517417.Cpar_2041	2.96e-36	134.0	COG3187@1|root,COG3187@2|Bacteria	2|Bacteria	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	META
k59_882953_1	509190.Cseg_1544	9.75e-30	114.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2TT2D@28211|Alphaproteobacteria,2KG42@204458|Caulobacterales	204458|Caulobacterales	H	Sulfate adenylyltransferase	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_882953_2	85643.Tmz1t_1627	1.47e-11	67.0	2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,2VNEU@28216|Betaproteobacteria,2KZPB@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_850410_1	110319.CF8_1813	5.81e-42	154.0	COG3666@1|root,COG3666@2|Bacteria,2IA0I@201174|Actinobacteria,4DW5K@85009|Propionibacteriales	201174|Actinobacteria	L	Protein involved in DNA binding, transposase activity and DNA transposition	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_394069_2	766499.C357_01310	1.43e-11	64.7	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_981721_1	1265502.KB905934_gene3271	9.95e-77	236.0	COG3279@1|root,COG3279@2|Bacteria,1MVJI@1224|Proteobacteria,2VPZX@28216|Betaproteobacteria,4AA5R@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM response regulator receiver	algR	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_784432_1	414684.RC1_3123	3.28e-47	164.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,2JQ3B@204441|Rhodospirillales	204441|Rhodospirillales	ET	general L-amino acid-binding periplasmic protein AapJ	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k59_784432_2	1123020.AUIE01000031_gene2800	1.67e-10	61.2	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria,1YFJX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
k59_165867_1	706587.Desti_0804	8.11e-56	187.0	COG2006@1|root,COG2006@2|Bacteria,1R6CE@1224|Proteobacteria,42QI7@68525|delta/epsilon subdivisions,2WJA0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_296272_2	1082933.MEA186_18517	2.21e-84	262.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2TT55@28211|Alphaproteobacteria,43JJ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	soxF	-	1.8.2.3,1.8.5.4	ko:K17218,ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499,R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
k59_492494_1	1499967.BAYZ01000104_gene3677	1.79e-52	183.0	COG2414@1|root,COG2414@2|Bacteria,2NP2Q@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_622936_1	1038859.AXAU01000015_gene937	1.26e-47	168.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVRF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_459349_2	323848.Nmul_A2296	8.76e-40	142.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,371XF@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Beta-lactamase enzyme family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_981734_1	545694.TREPR_2670	9.52e-26	104.0	COG0052@1|root,COG0052@2|Bacteria,2J5GZ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_981734_2	272626.lin1529	3.99e-07	53.1	COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,4HB8K@91061|Bacilli,26K3K@186820|Listeriaceae	91061|Bacilli	F	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_230876_1	1297742.A176_04424	1.26e-100	323.0	COG0308@1|root,COG0308@2|Bacteria,1NQIW@1224|Proteobacteria,4391T@68525|delta/epsilon subdivisions,2X47D@28221|Deltaproteobacteria,2YYES@29|Myxococcales	28221|Deltaproteobacteria	E	Phospholipase B	-	-	-	-	-	-	-	-	-	-	-	-	Phospholip_B
k59_784436_1	864051.BurJ1DRAFT_2686	1.19e-38	133.0	COG2391@1|root,COG2391@2|Bacteria,1N3PQ@1224|Proteobacteria,2VXAQ@28216|Betaproteobacteria,1KP4P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_784436_2	864051.BurJ1DRAFT_2687	5.28e-97	294.0	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,2VWMP@28216|Betaproteobacteria,1KNZM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_133302_1	1192034.CAP_6809	1.07e-41	153.0	COG3349@1|root,COG3349@2|Bacteria,1RAVN@1224|Proteobacteria,433WH@68525|delta/epsilon subdivisions,2X3VQ@28221|Deltaproteobacteria,2YX9K@29|Myxococcales	28221|Deltaproteobacteria	Q	FAD dependent oxidoreductase	-	-	-	ko:K09879	ko00906,map00906	-	R07541,R07560,R07857,R07858	RC01901,RC01965	ko00000,ko00001	-	-	-	Amino_oxidase
k59_263886_1	323848.Nmul_A2758	7.79e-96	293.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2VKNE@28216|Betaproteobacteria,372VG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_2544_1	330214.NIDE0204	2.18e-30	115.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,3J13F@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_2544_2	330214.NIDE0203	5.8e-124	367.0	COG0415@1|root,COG0415@2|Bacteria,3J0IW@40117|Nitrospirae	40117|Nitrospirae	H	Belongs to the DNA photolyase family	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_883794_1	926569.ANT_16350	2.85e-73	237.0	COG0449@1|root,COG0449@2|Bacteria,2G5T5@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_492512_1	1121405.dsmv_1594	2.13e-162	465.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,42MPB@68525|delta/epsilon subdivisions,2WJUV@28221|Deltaproteobacteria,2MJ5P@213118|Desulfobacterales	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_525014_1	640081.Dsui_0728	2.84e-103	313.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,2KUM9@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_426908_1	1123376.AUIU01000007_gene1178	1.9e-14	73.2	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,3J0E0@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_426908_2	1358423.N180_16765	1.2e-76	233.0	COG0302@1|root,COG0302@2|Bacteria,4NFC2@976|Bacteroidetes,1IPBD@117747|Sphingobacteriia	976|Bacteroidetes	H	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_784438_1	296591.Bpro_2800	2.19e-98	302.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VHRD@28216|Betaproteobacteria,4ABWV@80864|Comamonadaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	oxc	-	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100	-	R01908	RC00620	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_916953_1	557599.MKAN_14065	4.06e-34	137.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_329057_1	1123253.AUBD01000008_gene323	2.79e-46	163.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1X3E5@135614|Xanthomonadales	135614|Xanthomonadales	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_35357_1	67332.FM21_32410	8.8e-66	217.0	COG4993@1|root,COG4993@2|Bacteria,2I3R4@201174|Actinobacteria	201174|Actinobacteria	G	PQQ enzyme repeat	exaA	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2,PQQ_3
k59_263901_1	1268622.AVS7_03604	8.08e-79	248.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,4A9J9@80864|Comamonadaceae	28216|Betaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_916954_1	265072.Mfla_0994	2.14e-43	150.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,2KMT4@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_949342_1	29581.BW37_03040	4.36e-06	47.8	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2VQ7A@28216|Betaproteobacteria,4742P@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_1017368_2	555079.Toce_0370	1.34e-07	55.8	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,24FZX@186801|Clostridia,42EM3@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	degU	-	-	ko:K07692	ko02020,ko02024,map02020,map02024	M00478	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_566386_1	1110502.TMO_1372	1.98e-09	62.8	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2JPPM@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_566387_1	70601.3257003	6.66e-28	115.0	COG1052@1|root,arCOG01755@2157|Archaea,2XVDY@28890|Euryarchaeota,2432P@183968|Thermococci	183968|Thermococci	C	glyoxylate reductase activity	gyaR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_369798_1	114615.BRADO6815	5.81e-48	167.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TUIP@28211|Alphaproteobacteria,3JW9Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_109163_1	1161401.ASJA01000021_gene660	2.69e-30	112.0	2C7KN@1|root,336M6@2|Bacteria,1N4WC@1224|Proteobacteria,2UF7X@28211|Alphaproteobacteria,43YQA@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_109163_2	1121013.P873_09615	1.36e-21	93.6	COG0400@1|root,COG0400@2|Bacteria,1R1F5@1224|Proteobacteria,1T50A@1236|Gammaproteobacteria,1X5JJ@135614|Xanthomonadales	135614|Xanthomonadales	S	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
k59_697192_1	1485544.JQKP01000007_gene2023	4.02e-23	96.7	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,44V8D@713636|Nitrosomonadales	28216|Betaproteobacteria	HL	Thiamine monophosphate synthase	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,TMP-TENI
k59_697192_2	1031711.RSPO_c00678	1.48e-23	91.3	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2VXRV@28216|Betaproteobacteria,1KA41@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
k59_697192_3	1000565.METUNv1_00089	0.000135	43.5	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,2KUR3@206389|Rhodocyclales	206389|Rhodocyclales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_990029_1	1232410.KI421424_gene1640	3.54e-69	224.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2WNZJ@28221|Deltaproteobacteria,43TNK@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_466109_1	395965.Msil_1290	2.34e-80	252.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3NBII@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_631220_1	1210884.HG799464_gene10933	3.94e-22	96.3	COG3385@1|root,32DHU@2|Bacteria,2J3US@203682|Planctomycetes	1210884.HG799464_gene10933|-	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_337499_1	1357279.N018_15015	1.97e-15	84.0	COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,1RNF2@1236|Gammaproteobacteria,1Z8NR@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	gfo	-	1.1.1.361	ko:K18652	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_237694_1	391625.PPSIR1_12053	1.22e-67	218.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,42RMS@68525|delta/epsilon subdivisions,2WNG3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
k59_237694_2	1452718.JBOY01000013_gene893	7.58e-06	47.4	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
k59_1017378_1	983917.RGE_41630	1.6e-88	274.0	COG3170@1|root,COG3170@2|Bacteria,1MWZB@1224|Proteobacteria,2VNBQ@28216|Betaproteobacteria,1KK1P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
k59_109171_1	1454004.AW11_02718	5.92e-87	270.0	COG0591@1|root,COG0591@2|Bacteria,1PKDE@1224|Proteobacteria	1224|Proteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_109172_1	1163617.SCD_n00466	1.33e-27	109.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2VP72@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_206789_1	198094.BA_0311	2.38e-16	75.9	COG1335@1|root,COG1335@2|Bacteria,1V7MY@1239|Firmicutes,4HDR2@91061|Bacilli,1ZD1Q@1386|Bacillus	91061|Bacilli	Q	Isochorismatase family	yddQ	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_466126_1	945713.IALB_0185	3.57e-29	120.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
k59_891798_1	1126627.BAWE01000004_gene2715	5.9e-14	73.6	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2TQS4@28211|Alphaproteobacteria,3JUJ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	MA20_07165	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_891798_2	85643.Tmz1t_2272	2.67e-10	60.8	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,2KVF2@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_827747_1	323848.Nmul_A2627	3.1e-30	114.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,371SJ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_827747_2	339670.Bamb_0735	5.91e-31	109.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,1KA31@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Rubredoxin-type Fe(Cys)4 protein	rubA	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
k59_729642_2	314607.KB13_1178	5.99e-62	203.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,1KPR6@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_891800_1	266117.Rxyl_0931	1.03e-05	50.1	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_891800_2	1227454.C446_16515	2.48e-11	62.0	COG0346@1|root,arCOG02708@2157|Archaea,2XWTX@28890|Euryarchaeota,23VNA@183963|Halobacteria	183963|Halobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_730537_1	483219.LILAB_12355	1.97e-48	162.0	28R6X@1|root,2ZDKX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_207640_1	196367.JNFG01000031_gene8767	1.85e-97	305.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,1K1NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aconitate hydratase	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
k59_530167_1	1182553.XP_007751375.1	1.69e-53	189.0	COG2303@1|root,KOG1238@2759|Eukaryota,39T59@33154|Opisthokonta,3NWR9@4751|Fungi,3QNXB@4890|Ascomycota,20DZV@147545|Eurotiomycetes,3MQ7C@451870|Chaetothyriomycetidae	4751|Fungi	E	GMC oxidoreductase	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_665300_1	543913.D521_0815	8.35e-48	155.0	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2VSYU@28216|Betaproteobacteria	28216|Betaproteobacteria	E	4-carboxymuconolactone decarboxylase	pcaC	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,CMD
k59_665300_2	1121874.KB892380_gene1688	2.16e-16	80.9	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,3VPBB@526524|Erysipelotrichia	526524|Erysipelotrichia	D	Sporulation initiation inhibitor protein Soj	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_338319_1	330214.NIDE1304	3.74e-109	347.0	COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_110014_1	713586.KB900536_gene2860	2.52e-08	57.0	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K06149,ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_110014_2	557436.Lreu_1272	4.33e-09	59.7	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,4HB0Z@91061|Bacilli,3F3RM@33958|Lactobacillaceae	91061|Bacilli	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
k59_142689_1	1408254.T458_14780	2.01e-63	207.0	COG2234@1|root,COG2234@2|Bacteria,1UWII@1239|Firmicutes,4IA2X@91061|Bacilli,272AH@186822|Paenibacillaceae	91061|Bacilli	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_370622_1	1366050.N234_24800	2.16e-119	362.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2VHEX@28216|Betaproteobacteria,1K5MH@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_926477_1	1288494.EBAPG3_7950	3.83e-88	281.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3725J@32003|Nitrosomonadales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_828618_1	391165.GbCGDNIH1_0192	4.89e-17	78.2	COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2U98I@28211|Alphaproteobacteria,2JSWH@204441|Rhodospirillales	204441|Rhodospirillales	M	COG1247 Sortase and related acyltransferases	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
k59_828618_2	1216976.AX27061_0723	8.69e-12	67.4	COG3181@1|root,COG3181@2|Bacteria,1R8PF@1224|Proteobacteria,2VP6F@28216|Betaproteobacteria,3T5FE@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_304958_2	6238.CBG25534	6.85e-59	201.0	KOG4740@1|root,KOG4740@2759|Eukaryota,3A4S6@33154|Opisthokonta,3BUQE@33208|Metazoa,3E551@33213|Bilateria,40FH4@6231|Nematoda,1KYF2@119089|Chromadorea,4150V@6236|Rhabditida	33208|Metazoa	S	proton channel activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_599723_2	1458427.BAWN01000028_gene1631	3.53e-23	102.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,4AB39@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_435895_1	864051.BurJ1DRAFT_1065	3.05e-15	70.5	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,1KKPH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_730555_1	1095767.CAHD01000193_gene195	1.53e-48	175.0	COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4F134@85016|Cellulomonadaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65, C-terminal domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
k59_730555_2	1232410.KI421424_gene1796	2e-32	115.0	COG1554@1|root,COG1554@2|Bacteria	2|Bacteria	G	hydrolase, family 65, central catalytic	-	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0030312,GO:0044464,GO:0071944	2.4.1.230,2.4.1.64	ko:K05342,ko:K10231	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_892599_1	398525.KB900701_gene6497	2.95e-71	229.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TU6U@28211|Alphaproteobacteria,3JXF6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_304967_2	1424334.W822_03990	1.38e-15	77.4	COG3836@1|root,COG3836@2|Bacteria,1PE5B@1224|Proteobacteria,2W9U5@28216|Betaproteobacteria,3T7EH@506|Alcaligenaceae	28216|Betaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_238402_1	391615.ABSJ01000026_gene121	7.4e-47	163.0	2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_959011_1	649638.Trad_0749	2.23e-130	387.0	COG0033@1|root,COG0033@2|Bacteria,1WJDJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_892601_1	330214.NIDE2173	7.71e-22	102.0	COG4774@1|root,COG4774@2|Bacteria	2|Bacteria	P	siderophore transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,STN,TonB_dep_Rec
k59_926496_2	436308.Nmar_0597	9.21e-39	132.0	COG0073@1|root,arCOG01136@2157|Archaea,41SSY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Putative tRNA binding domain	-	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
k59_530180_1	933262.AXAM01000009_gene1489	2.8e-108	330.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria,2MHWQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	reductase, alpha subunit	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_175352_1	345341.KUTG_03857	1.89e-21	95.5	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria	201174|Actinobacteria	P	sulfurtransferase	sseA2	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_175352_2	543913.D521_0582	7.14e-63	201.0	COG3386@1|root,COG3386@2|Bacteria,1MXVD@1224|Proteobacteria,2VHTM@28216|Betaproteobacteria	28216|Betaproteobacteria	G	gluconolactonase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_665338_1	298386.PBPRA1562	8.07e-12	67.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1XSXA@135623|Vibrionales	135623|Vibrionales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_502142_1	398767.Glov_3615	1.56e-32	125.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
k59_502142_2	1444306.JFZC01000011_gene1964	1.11e-07	53.5	COG1028@1|root,COG1028@2|Bacteria,1TZY6@1239|Firmicutes,4HEU2@91061|Bacilli,26NVW@186821|Sporolactobacillaceae	91061|Bacilli	IQ	KR domain	ymfI	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_142731_3	1238182.C882_3454	2.83e-23	94.4	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VGB4@28211|Alphaproteobacteria,2JS51@204441|Rhodospirillales	204441|Rhodospirillales	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_632140_1	1121015.N789_00545	6.65e-86	275.0	COG0277@1|root,COG4798@1|root,COG0277@2|Bacteria,COG4798@2|Bacteria,1MV1Q@1224|Proteobacteria,1RSC3@1236|Gammaproteobacteria,1X35W@135614|Xanthomonadales	135614|Xanthomonadales	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4,Methyltransf_11
k59_760653_2	1185876.BN8_03039	6.71e-28	107.0	28K10@1|root,2Z9QW@2|Bacteria,4NF8J@976|Bacteroidetes,47KRG@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4918)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4918
k59_599757_1	945713.IALB_1461	6.97e-47	156.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_110070_1	391625.PPSIR1_07887	2.73e-30	120.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2YVU0@29|Myxococcales	28221|Deltaproteobacteria	T	Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos,Metallophos_2
k59_787477_1	1454004.AW11_03689	8.8e-153	441.0	2C8FN@1|root,2ZBER@2|Bacteria,1RK02@1224|Proteobacteria,2WG0U@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_787477_2	565045.NOR51B_1271	1.1e-41	147.0	COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Secreted protein, containing von Willebrand factor (VWF) type	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_860402_1	1336208.JADY01000004_gene3585	5.43e-48	169.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales	204441|Rhodospirillales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
k59_632153_1	313606.M23134_03375	1.53e-39	148.0	COG3975@1|root,COG3975@2|Bacteria,4NE4D@976|Bacteroidetes,47NWB@768503|Cytophagia	976|Bacteroidetes	S	M61 glycyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
k59_401697_1	1163617.SCD_n00209	7.38e-128	375.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2VH1E@28216|Betaproteobacteria	28216|Betaproteobacteria	F	dihydroorotase	pyrX	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_599768_1	406818.XBJ1_3918	4.9e-45	160.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	IS30 family	ISPlu1B	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_828677_1	329726.AM1_6037	3.87e-68	218.0	COG3547@1|root,COG3547@2|Bacteria,1G1N1@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase is116 is110 is902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_435935_1	1172188.KB911821_gene2076	5.16e-90	278.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,2GNPX@201174|Actinobacteria,4FFVN@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	osaB	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_860404_1	1123504.JQKD01000024_gene294	1.01e-12	68.2	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,4AA9X@80864|Comamonadaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_860404_2	1380394.JADL01000001_gene2257	4.3e-39	140.0	COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,2U4JI@28211|Alphaproteobacteria,2JUE6@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_207711_1	1049564.TevJSym_ac00600	1.84e-82	262.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
k59_959058_1	257313.BP3240	7.81e-68	231.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_860418_1	671143.DAMO_2166	1.02e-07	50.8	COG4451@1|root,COG4451@2|Bacteria	2|Bacteria	C	ribulose-bisphosphate carboxylase activity	cbbS	-	4.1.1.39	ko:K01602	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_small
k59_860418_2	305700.B447_09153	5.95e-119	352.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,2KV1C@206389|Rhodocyclales	206389|Rhodocyclales	H	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_896951_1	1288494.EBAPG3_10330	3.09e-89	275.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,3724N@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_896951_2	1286093.C266_02863	2.49e-48	170.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2VJGZ@28216|Betaproteobacteria,1JZZ7@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Lytic murein transglycosylase B	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_833553_1	555779.Dthio_PD0022	2.84e-27	117.0	COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_572061_1	506534.Rhein_1957	4.58e-17	89.0	COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RZW9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Reg_prop,Y_Y_Y
k59_49222_1	1340493.JNIF01000003_gene4392	3.77e-19	85.9	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07499	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_29,HTH_32,HTH_33
k59_49222_2	1267535.KB906767_gene2036	3.78e-57	184.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
k59_147424_1	945713.IALB_2113	3.44e-45	164.0	COG0323@1|root,COG0323@2|Bacteria	2|Bacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	2.1.1.37	ko:K00558,ko:K03572	ko00270,ko01100,ko03430,ko05206,map00270,map01100,map03430,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036,ko03400	-	-	-	DNA_mis_repair,HATPase_c,HATPase_c_3,MutL_C
k59_17065_1	1304885.AUEY01000030_gene2426	1.34e-48	177.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MIBK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_506787_1	1229909.NSED_09790	1.69e-52	166.0	COG3432@1|root,arCOG01055@2157|Archaea,41T3P@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
k59_506787_2	1229909.NSED_09795	6.83e-37	134.0	COG2512@1|root,arCOG00374@2157|Archaea,41SUX@651137|Thaumarchaeota	651137|Thaumarchaeota	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114730_2	472759.Nhal_3572	6.47e-63	201.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1WW93@135613|Chromatiales	135613|Chromatiales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_735391_1	1121381.JNIV01000032_gene2525	5.01e-24	110.0	COG3055@1|root,COG3250@1|root,COG3055@2|Bacteria,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060,Kelch_1,Kelch_6,NPCBM,SpoIIE
k59_735391_2	305700.B447_11277	1.27e-26	104.0	COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,2VRCD@28216|Betaproteobacteria,2KWCR@206389|Rhodocyclales	206389|Rhodocyclales	S	Uncharacterised protein family (UPF0227)	-	-	-	ko:K07000	-	-	-	-	ko00000	-	-	-	UPF0227
k59_375127_1	589865.DaAHT2_1555	4.98e-23	94.4	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,42YY2@68525|delta/epsilon subdivisions,2WUI6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_375127_2	1123368.AUIS01000004_gene171	2.13e-08	55.1	COG0848@1|root,COG0848@2|Bacteria,1NE2R@1224|Proteobacteria,1TDF9@1236|Gammaproteobacteria,2NCUK@225057|Acidithiobacillales	225057|Acidithiobacillales	U	Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_865036_1	945713.IALB_1543	4.79e-73	234.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	fadL	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_931971_1	1454004.AW11_02080	8.31e-15	73.2	COG0166@1|root,COG0166@2|Bacteria,1PQU4@1224|Proteobacteria,2VKX3@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the GPI family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_375802_1	626418.bglu_1g24480	1.58e-60	199.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,1K4UW@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_343712_1	330214.NIDE1575	3.63e-29	114.0	COG2215@1|root,COG2215@2|Bacteria	2|Bacteria	O	Belongs to the NiCoT transporter (TC 2.A.52) family	ureH	-	-	-	-	-	-	-	-	-	-	-	DsbD_2,NicO
k59_343712_2	330214.NIDE1574	4.03e-50	169.0	COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_14,Mob_synth_C,Radical_SAM
k59_212925_1	273068.TTE0188	5.89e-46	163.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,247Q5@186801|Clostridia,42FAB@68295|Thermoanaerobacterales	186801|Clostridia	C	of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_406160_2	1173022.Cri9333_4567	7.56e-09	55.8	COG4249@1|root,COG4249@2|Bacteria,1GQXT@1117|Cyanobacteria,1HBPN@1150|Oscillatoriales	1117|Cyanobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
k59_406160_3	631454.N177_0240	3.76e-33	122.0	COG3439@1|root,COG3439@2|Bacteria,1RHPD@1224|Proteobacteria,2U95F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_83128_1	237368.SCABRO_02892	1.88e-118	357.0	28HMZ@1|root,2Z7WD@2|Bacteria,2J2EK@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_834248_1	436308.Nmar_1111	1.75e-69	223.0	COG2379@1|root,arCOG04170@2157|Archaea,41SJF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_180617_1	1288494.EBAPG3_7770	3.08e-19	83.2	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,2VTYZ@28216|Betaproteobacteria,3739X@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
k59_180617_2	1266925.JHVX01000008_gene347	1.06e-130	395.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,371VQ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_637409_1	1485544.JQKP01000003_gene126	9.9e-47	159.0	COG3448@1|root,COG3448@2|Bacteria,1QUQ5@1224|Proteobacteria,2WGXX@28216|Betaproteobacteria,44VRR@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_180618_1	318996.AXAZ01000120_gene2538	6.91e-35	130.0	COG0454@1|root,COG0456@2|Bacteria,1R8G2@1224|Proteobacteria,2U8TP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_834251_1	880072.Desac_2527	4.65e-63	201.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,2MQE6@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_736142_1	330214.NIDE2085	2.38e-33	132.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
k59_17761_2	653045.Strvi_7747	1.11e-45	155.0	COG3740@1|root,COG3740@2|Bacteria,2IDPK@201174|Actinobacteria	201174|Actinobacteria	S	Caudovirus prohead serine protease	-	-	-	ko:K06904	-	-	-	-	ko00000	-	-	-	Peptidase_S78
k59_343728_1	29581.BW37_05180	1.89e-94	280.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2VJVJ@28216|Betaproteobacteria,4724K@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
k59_115437_1	330214.NIDE3564	1.38e-74	249.0	COG4548@1|root,COG4548@2|Bacteria	2|Bacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_931992_1	329726.AM1_4072	6.36e-29	122.0	COG1716@1|root,COG2202@1|root,COG5001@1|root,COG1716@2|Bacteria,COG2202@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GGDEF,PAS_3
k59_507522_1	1163617.SCD_n00156	3.99e-79	243.0	COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,2VJ7R@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Transport permease protein	nodJ	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
k59_507522_2	1286093.C266_05204	3.66e-05	44.7	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VI3G@28216|Betaproteobacteria,1JZWV@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit is responsible for energy coupling to the transport system	nodI	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
k59_865758_1	34506.g2924	1.95e-56	199.0	COG5013@1|root,2RPGA@2759|Eukaryota,3AFF8@33154|Opisthokonta,3BXZ5@33208|Metazoa,3DE38@33213|Bilateria	33208|Metazoa	C	Respiratory nitrate reductase alpha N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_115442_1	1167006.UWK_02567	6.73e-22	95.9	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WM55@28221|Deltaproteobacteria,2MPY6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_964611_1	391593.RCCS2_01518	4.97e-37	132.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U75U@28211|Alphaproteobacteria,2P371@2433|Roseobacter	28211|Alphaproteobacteria	Q	COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_964611_2	402881.Plav_2880	1.52e-56	191.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,1JNDU@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_605046_1	391589.RGAI101_1820	3.95e-42	149.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,2P43F@2433|Roseobacter	28211|Alphaproteobacteria	I	COG1024 Enoyl-CoA hydratase carnithine racemase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_897595_1	1384054.N790_01970	6.01e-53	175.0	COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,1S772@1236|Gammaproteobacteria,1X6G4@135614|Xanthomonadales	135614|Xanthomonadales	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_897595_2	1095769.CAHF01000001_gene3553	2.66e-38	136.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VHFS@28216|Betaproteobacteria,4737I@75682|Oxalobacteraceae	28216|Betaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	gltI	-	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_703763_1	1313172.YM304_05680	1.4e-33	119.0	2AEFI@1|root,314AK@2|Bacteria,2HDRV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_532764_1	420662.Mpe_A2424	2.07e-50	162.0	COG0640@1|root,COG0640@2|Bacteria,1Q9DY@1224|Proteobacteria,2VVWF@28216|Betaproteobacteria,1KMER@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_212953_1	859657.RPSI07_1192	2.06e-69	234.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1K0FY@119060|Burkholderiaceae	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_670935_1	926569.ANT_11390	1.92e-71	224.0	COG0005@1|root,COG0005@2|Bacteria,2G5JP@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_275104_1	697282.Mettu_3259	5.4e-136	396.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XEUM@135618|Methylococcales	135618|Methylococcales	P	PFAM Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_932019_1	452637.Oter_3284	1.46e-29	118.0	COG2909@1|root,COG3710@1|root,COG2909@2|Bacteria,COG3710@2|Bacteria,46UY3@74201|Verrucomicrobia	74201|Verrucomicrobia	K	PFAM transcriptional regulator domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
k59_834283_1	1229172.JQFA01000005_gene80	2.57e-25	110.0	COG0859@1|root,COG0859@2|Bacteria,1G4H4@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
k59_507545_1	1485544.JQKP01000011_gene728	7.33e-107	323.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,44VP0@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_507545_2	1121396.KB893131_gene3666	9.32e-07	50.1	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,2MJ22@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
k59_670941_1	1056820.KB900629_gene1768	1.58e-24	102.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,2PPWD@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_343761_1	1049564.TevJSym_bh00140	7.14e-100	298.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1J4N9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0714 MoxR-like ATPases	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_670946_2	1038866.KB902768_gene5005	4.93e-16	82.4	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_507567_1	330214.NIDE1005	4.81e-84	258.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_637469_1	1123392.AQWL01000005_gene3107	5.9e-81	248.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,1KRR5@119069|Hydrogenophilales	119069|Hydrogenophilales	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_212999_1	713586.KB900536_gene2525	1.69e-73	232.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_532787_2	492774.JQMB01000017_gene747	3.28e-19	89.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,4B8YA@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Glycolate oxidase subunit	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_834327_1	388051.AUFE01000005_gene1094	1.65e-82	251.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHZW@28216|Betaproteobacteria,1K11F@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_115504_1	261292.Nit79A3_1902	4.01e-07	50.1	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,372UA@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_115504_2	395493.BegalDRAFT_2635	3.55e-45	159.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,45ZW6@72273|Thiotrichales	72273|Thiotrichales	J	ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_736219_1	338969.Rfer_4052	3.72e-44	149.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,4AE3J@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	aut	-	2.7.7.70	ko:K21345	ko00540,ko01100,map00540,map01100	M00064	R05644	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_736219_2	666681.M301_2437	5.1e-47	160.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria,2KMN0@206350|Nitrosomonadales	206350|Nitrosomonadales	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_736219_3	296591.Bpro_0392	5.53e-16	74.3	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria,4ABNW@80864|Comamonadaceae	28216|Betaproteobacteria	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
k59_605115_1	247639.MGP2080_13909	8.53e-47	171.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_213015_1	1123296.JQKE01000017_gene1799	7.22e-50	170.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,2KQ69@206351|Neisseriales	206351|Neisseriales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_213015_2	105559.Nwat_0350	6.02e-62	198.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1WWA2@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_637498_1	1121355.KB903376_gene1072	5.59e-10	62.0	COG2860@1|root,COG2860@2|Bacteria,2GMI4@201174|Actinobacteria,22KMW@1653|Corynebacteriaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
k59_637498_2	216594.MMAR_1579	1.48e-87	279.0	COG1574@1|root,COG1574@2|Bacteria,2IBQ5@201174|Actinobacteria,23CEY@1762|Mycobacteriaceae	201174|Actinobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_964693_1	485913.Krac_4763	9.14e-31	122.0	COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_148231_2	196367.JNFG01000202_gene2562	2.75e-36	130.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VQAE@28216|Betaproteobacteria,1KH7X@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_213023_1	349163.Acry_0334	3.07e-19	85.5	COG3118@1|root,COG3118@2|Bacteria,1QVD0@1224|Proteobacteria,2UAGJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	hydrogenase expression formation protein	hupG	-	-	ko:K03619	-	-	-	-	ko00000	-	-	-	HyaE
k59_532802_1	522306.CAP2UW1_0301	5.82e-45	154.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2VHC6@28216|Betaproteobacteria,1KQI4@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_532802_2	640081.Dsui_1307	1.7e-16	76.3	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,2VQ4C@28216|Betaproteobacteria,2KYC0@206389|Rhodocyclales	206389|Rhodocyclales	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K05501	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	TetR_N
k59_834365_1	1333998.M2A_0658	9.11e-32	119.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TTVF@28211|Alphaproteobacteria,4BRV0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	idnO	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_679403_2	1123367.C666_08860	2.36e-24	93.2	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2VVUH@28216|Betaproteobacteria,2KX71@206389|Rhodocyclales	206389|Rhodocyclales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_679403_3	1266925.JHVX01000008_gene286	3.28e-59	201.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,372JH@32003|Nitrosomonadales	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1004087_1	580332.Slit_2285	4.45e-33	119.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VRCR@28216|Betaproteobacteria,44WEK@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Bacterial protein of unknown function (DUF899)	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_1004087_2	882378.RBRH_03973	4.93e-57	183.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2VQA2@28216|Betaproteobacteria,1JZN6@119060|Burkholderiaceae	28216|Betaproteobacteria	G	peptidyl-prolyl	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_1004087_3	395495.Lcho_3483	8.71e-20	90.5	COG1408@1|root,COG1408@2|Bacteria,1QW5K@1224|Proteobacteria,2WH7T@28216|Betaproteobacteria	28216|Betaproteobacteria	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_581228_1	1121035.AUCH01000003_gene1378	2.89e-146	464.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KUBP@206389|Rhodocyclales	206389|Rhodocyclales	KNT	COG0643 Chemotaxis protein histidine kinase and related kinases	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
k59_123573_1	247633.GP2143_11459	3.66e-46	162.0	COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,1RMS4@1236|Gammaproteobacteria,1J9UQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferase family 21	pgaC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0007155,GO:0008150,GO:0008194,GO:0008375,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044464,GO:0044764,GO:0051704,GO:0071944,GO:0090605	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
k59_279293_1	1463857.JOFZ01000007_gene163	3.3e-159	461.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_1004100_1	592029.DDD_1447	5.24e-38	144.0	COG2264@1|root,COG2264@2|Bacteria	2|Bacteria	J	protein methyltransferase activity	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_21,Methyltransf_23,PrmA,rRNA_methylase
k59_188327_1	426114.THI_0388	1.77e-71	223.0	COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,2VJ8A@28216|Betaproteobacteria,1KK9S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	gltJ	-	-	ko:K02029,ko:K10003	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	BPD_transp_1
k59_478341_1	713587.THITH_03965	5.15e-27	107.0	COG1416@1|root,COG1416@2|Bacteria,1N64N@1224|Proteobacteria,1SNQX@1236|Gammaproteobacteria,1X1RU@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_413409_1	765911.Thivi_0796	5.23e-28	112.0	COG4262@1|root,COG4262@2|Bacteria,1RFZS@1224|Proteobacteria,1S1NP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_842808_1	381666.H16_A1821	4.17e-123	359.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKD3@28216|Betaproteobacteria,1K0J2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF2063,DUF692
k59_383450_1	414684.RC1_3768	6.22e-80	244.0	COG1083@1|root,COG1083@2|Bacteria,1QACI@1224|Proteobacteria,2U5PV@28211|Alphaproteobacteria,2JU2N@204441|Rhodospirillales	204441|Rhodospirillales	M	Cytidylyltransferase	-	-	2.7.7.43	ko:K00983	ko00520,ko01100,map00520,map01100	-	R01117,R04215	RC00152	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3
k59_383450_2	316055.RPE_4238	1.67e-16	80.9	COG0021@1|root,COG0021@2|Bacteria,1QYA4@1224|Proteobacteria,2TXK4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	XFP N-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_188331_1	522306.CAP2UW1_2222	4.64e-113	337.0	28IWG@1|root,2Z8US@2|Bacteria,1NHDW@1224|Proteobacteria,2VPYM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
k59_91562_2	1089544.KB912942_gene7340	2.99e-10	66.2	COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria,4E25R@85010|Pseudonocardiales	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.103,4.1.1.46	ko:K14333,ko:K20941	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R00821,R11353	RC00390,RC00569	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_156333_1	83406.HDN1F_24010	1.63e-109	328.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_123590_1	1415779.JOMH01000001_gene179	4.37e-92	280.0	COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Pfam MotA TolQ ExbB proton channel family	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_250101_1	648996.Theam_0649	2.79e-38	142.0	COG0405@1|root,COG0405@2|Bacteria,2G3M5@200783|Aquificae	200783|Aquificae	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_842813_1	1001585.MDS_2815	4.93e-89	276.0	COG3385@1|root,COG3385@2|Bacteria,1PQZT@1224|Proteobacteria,1TBQQ@1236|Gammaproteobacteria,1YIJZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_645537_1	98439.AJLL01000101_gene419	1.48e-15	70.5	COG2343@1|root,COG2343@2|Bacteria,1G7U6@1117|Cyanobacteria,1JIWP@1189|Stigonemataceae	1117|Cyanobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_645537_2	1395571.TMS3_0107090	5.66e-52	177.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	methyltransferase	sumf2	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_91575_1	1227349.C170_12360	3.74e-53	179.0	COG2141@1|root,COG2141@2|Bacteria,1TT4S@1239|Firmicutes,4HBJB@91061|Bacilli,26SP5@186822|Paenibacillaceae	91061|Bacilli	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	luxA_2	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_744649_1	1397666.RS24_01980	1.19e-117	346.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,4BPNQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_940418_1	330214.NIDE1017	1.01e-69	220.0	COG0772@1|root,COG0772@2|Bacteria,3J0IA@40117|Nitrospirae	40117|Nitrospirae	D	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_279305_1	574087.Acear_0633	3.34e-19	92.8	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,3WBDT@53433|Halanaerobiales	186801|Clostridia	E	PFAM extracellular solute-binding protein family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_220873_1	998088.B565_0949	2.04e-24	97.8	COG3029@1|root,COG3029@2|Bacteria,1RD34@1224|Proteobacteria,1S419@1236|Gammaproteobacteria,1Y4RQ@135624|Aeromonadales	135624|Aeromonadales	C	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane	frdC	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Fumarate_red_C
k59_220873_2	987059.RBXJA2T_17052	4.99e-138	395.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VNVE@28216|Betaproteobacteria,1KN4J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	frdB	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
k59_91580_2	215803.DB30_4843	4.09e-33	119.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,4360E@68525|delta/epsilon subdivisions,2X0HX@28221|Deltaproteobacteria,2Z0TS@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_26001_1	509191.AEDB02000035_gene2165	2.02e-30	123.0	COG0464@1|root,COG0464@2|Bacteria,1TQTZ@1239|Firmicutes,24C5G@186801|Clostridia,3WHT1@541000|Ruminococcaceae	186801|Clostridia	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_873820_2	1268068.PG5_61520	4.13e-52	173.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_91584_1	330214.NIDE4362	7.69e-57	181.0	COG1611@1|root,COG1611@2|Bacteria,3J0TX@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	-
k59_91584_2	330214.NIDE4360	1.44e-49	164.0	COG0225@1|root,COG0225@2|Bacteria	2|Bacteria	O	peptide-methionine (S)-S-oxide reductase activity	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_792865_1	189753.AXAS01000012_gene4270	1.45e-120	363.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,3JVT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_581287_1	1163617.SCD_n02108	5.15e-74	233.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_220883_1	985665.HPL003_20485	1.66e-19	92.4	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26TIQ@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1004146_1	748247.AZKH_2240	4.78e-61	200.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,2KVBK@206389|Rhodocyclales	206389|Rhodocyclales	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_744673_1	268407.PWYN_12330	1.02e-28	112.0	COG5263@1|root,COG5263@2|Bacteria	2|Bacteria	S	dextransucrase activity	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_1,Lyase_8,Lyase_8_C,Lyase_8_N,Pentapeptide_2,Peptidase_C69,SLH,WG_beta_rep
k59_478384_1	190650.CC_2729	7.56e-125	363.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,2KK21@204458|Caulobacterales	204458|Caulobacterales	L	leucine-zipper of insertion element IS481	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,rve
k59_478384_2	883078.HMPREF9695_00466	4.3e-61	190.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,3JZ99@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_645571_1	1173024.KI912151_gene2197	6.55e-84	265.0	COG1894@1|root,COG1894@2|Bacteria,1G2KY@1117|Cyanobacteria,1JKPW@1189|Stigonemataceae	1117|Cyanobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	hoxF	-	1.6.5.3	ko:K05587	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_123635_1	1131266.ARWQ01000010_gene36	1.34e-26	97.8	arCOG11928@1|root,arCOG11928@2157|Archaea,41T8Q@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_123635_2	1229909.NSED_02355	1.08e-31	122.0	arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_873840_1	765911.Thivi_3855	4.48e-60	208.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales	135613|Chromatiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_317336_1	573063.Metin_0089	1.08e-77	240.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,23QFB@183939|Methanococci	183939|Methanococci	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_973133_1	621372.ACIH01000243_gene1315	4.08e-28	112.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,4H9X5@91061|Bacilli,26R33@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_712256_1	330214.NIDE3293	2.19e-13	70.5	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,DHOR,DUF3365,FixO,PSCyt1
k59_712256_2	330214.NIDE3294	5.03e-135	388.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_1024559_1	330214.NIDE4173	3.54e-107	324.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
k59_712260_1	1123013.AUIC01000003_gene407	4.45e-52	183.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4FKZJ@85023|Microbacteriaceae	201174|Actinobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
k59_156394_1	1238182.C882_0228	7.33e-86	280.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JRMJ@204441|Rhodospirillales	204441|Rhodospirillales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_123644_1	935948.KE386494_gene944	1.09e-49	171.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_156395_1	95619.PM1_0219330	1.39e-39	149.0	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	ykoW	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_973144_1	330214.NIDE0352	8.39e-58	202.0	COG0308@1|root,COG0308@2|Bacteria,3J0Y4@40117|Nitrospirae	40117|Nitrospirae	E	Peptidase family M1 domain	-	-	-	ko:K08776	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_413474_2	883126.HMPREF9710_02007	1.84e-67	213.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,472Y8@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_449039_1	1266925.JHVX01000006_gene2154	9.86e-85	263.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,372CM@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Domain of unknown function DUF21	corB	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_772709_2	426355.Mrad2831_4009	2.08e-26	109.0	COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,2TTFI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp,EamA
k59_1024566_1	864051.BurJ1DRAFT_4690	1.14e-85	285.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_26046_1	397948.Cmaq_0649	3.55e-79	247.0	COG1082@1|root,arCOG01895@2157|Archaea	2157|Archaea	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
k59_57730_1	1229909.NSED_02310	6.11e-78	245.0	COG0475@1|root,arCOG01955@2157|Archaea,41SG1@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
k59_679498_1	1297569.MESS2_1060013	3.09e-30	116.0	COG0697@1|root,COG0697@2|Bacteria,1MXPW@1224|Proteobacteria,2TRXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
k59_679498_2	1432055.GLUCORHAEAF1_14665	8.76e-22	91.3	COG1028@1|root,COG1028@2|Bacteria,1MXE0@1224|Proteobacteria,2U1P2@28211|Alphaproteobacteria,2JSC5@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_156405_1	1122247.C731_4351	7.37e-19	85.1	COG5517@1|root,COG5517@2|Bacteria,2GR5G@201174|Actinobacteria,23BED@1762|Mycobacteriaceae	201174|Actinobacteria	Q	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
k59_744716_1	1288494.EBAPG3_21660	1.02e-111	335.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,372E5@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_188420_1	1191523.MROS_2609	2.57e-62	208.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,PSII_BNR
k59_905480_1	196490.AUEZ01000063_gene1544	1.01e-48	166.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_905480_2	1054213.HMPREF9946_01848	7.96e-14	73.9	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_383532_1	926550.CLDAP_40100	5.18e-104	313.0	COG1879@1|root,COG1879@2|Bacteria,2G8BJ@200795|Chloroflexi	200795|Chloroflexi	G	Periplasmic binding protein domain	-	-	-	ko:K10559	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	Peripla_BP_4
k59_515966_1	497321.C664_06423	1.38e-11	64.7	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,2KW06@206389|Rhodocyclales	206389|Rhodocyclales	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_515966_2	522306.CAP2UW1_3199	2.57e-23	96.3	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VSIN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Molybdopterin-guanine dinucleotide biosynthesis protein MobA	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_613256_1	28229.ND2E_2955	1.99e-16	83.2	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,2Q646@267889|Colwelliaceae	1236|Gammaproteobacteria	C	Cytochrome c	cc4	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_613256_2	765911.Thivi_1817	3.06e-21	97.8	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,1S0TR@1236|Gammaproteobacteria,1WZ58@135613|Chromatiales	135613|Chromatiales	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_413494_2	237368.SCABRO_01661	1.82e-62	199.0	COG1611@1|root,COG1611@2|Bacteria,2IZK9@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_57750_1	1286631.X805_10550	1.46e-73	238.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2VJWM@28216|Betaproteobacteria,1KKIB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Na+/Pi-cotransporter	nptA	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_124434_1	1502851.FG93_01001	4.31e-194	552.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JX4Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_646344_1	935863.AWZR01000001_gene1769	1.79e-20	91.3	COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,1RR61@1236|Gammaproteobacteria,1X54U@135614|Xanthomonadales	135614|Xanthomonadales	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
k59_195616_2	1177154.Y5S_01215	6.3e-08	53.5	COG3295@1|root,COG3295@2|Bacteria,1N1RD@1224|Proteobacteria,1S8VS@1236|Gammaproteobacteria,1XMJ5@135619|Oceanospirillales	135619|Oceanospirillales	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
k59_227919_1	926550.CLDAP_02700	4.33e-105	326.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_195628_1	1121875.KB907548_gene1638	1.74e-34	130.0	COG0644@1|root,COG0644@2|Bacteria,4P040@976|Bacteroidetes	976|Bacteroidetes	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_620323_1	945713.IALB_2800	4.12e-88	271.0	COG0174@1|root,COG0174@2|Bacteria	2|Bacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1011039_1	1123504.JQKD01000044_gene2150	8.97e-37	139.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,4ABB4@80864|Comamonadaceae	28216|Betaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_324067_1	1121405.dsmv_0691	2.67e-210	597.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_64868_1	196490.AUEZ01000046_gene6789	3.93e-81	248.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2U18X@28211|Alphaproteobacteria,3JTGT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	MA20_28785	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_390818_1	675815.VOA_001043	1.25e-36	140.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria,1Y32Z@135623|Vibrionales	135623|Vibrionales	T	COG0642 Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,Response_reg,SBP_bac_3
k59_484467_1	1040987.AZUY01000002_gene3855	1.82e-11	64.3	COG1309@1|root,COG1309@2|Bacteria,1RDM7@1224|Proteobacteria,2U83S@28211|Alphaproteobacteria,43HPZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	ko:K02167	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_6,TetR_N
k59_484467_2	1122135.KB893134_gene3130	2e-31	120.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TU8Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,CTP_transf_3
k59_324078_2	497321.C664_19936	9.45e-95	283.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2W1UV@28216|Betaproteobacteria,2M00P@206389|Rhodocyclales	28216|Betaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_880882_1	1121875.KB907546_gene2451	2.9e-55	190.0	COG3118@1|root,COG3118@2|Bacteria,4PMAJ@976|Bacteroidetes,1IJPK@117743|Flavobacteriia	976|Bacteroidetes	O	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
k59_456172_1	795666.MW7_0758	1.42e-61	208.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,1K50V@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
k59_195664_1	926569.ANT_03990	3.35e-82	254.0	COG3684@1|root,COG3684@2|Bacteria,2G5XK@200795|Chloroflexi	200795|Chloroflexi	G	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	lacD	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
k59_540595_1	748247.AZKH_4585	1.1e-61	204.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2VJYX@28216|Betaproteobacteria,2KUE8@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_540595_2	85643.Tmz1t_3940	2.44e-08	54.3	COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,2VMRF@28216|Betaproteobacteria,2KWN7@206389|Rhodocyclales	206389|Rhodocyclales	O	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly	ureE	-	-	ko:K03187	-	-	-	-	ko00000	-	-	-	UreE_C,UreE_N
k59_419786_1	261292.Nit79A3_3209	4.27e-14	72.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,371XE@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_227962_1	204773.HEAR0765	7.57e-28	102.0	2DNSI@1|root,32YXC@2|Bacteria,1N7K2@1224|Proteobacteria,2VVXF@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_195677_1	1125863.JAFN01000001_gene2444	2.89e-96	291.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_652610_7	1097668.BYI23_B000570	1.29e-18	82.4	2DP7B@1|root,330UW@2|Bacteria,1N84K@1224|Proteobacteria,2VWFY@28216|Betaproteobacteria,1K8JU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4406)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4406
k59_256423_1	1123072.AUDH01000005_gene1662	9.28e-83	253.0	COG1024@1|root,COG1024@2|Bacteria,1MW41@1224|Proteobacteria,2TUR5@28211|Alphaproteobacteria,2JVHC@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_912397_1	671143.DAMO_2498	1.44e-95	288.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_912402_1	1459636.NTE_03212	8.58e-68	223.0	COG0516@1|root,arCOG00612@2157|Archaea,41S7R@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_324134_1	1117318.PRUB_18297	2.42e-10	62.4	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,2PZJ0@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	Belongs to the DnaA family. HdA subfamily	hda	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
k59_324134_2	243233.MCA0372	1.7e-07	54.7	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1XGEW@135618|Methylococcales	135618|Methylococcales	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_880926_1	926566.Terro_0945	9.96e-06	53.9	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_283251_1	1121441.AUCX01000005_gene1259	2.37e-18	87.8	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2M9GU@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_256438_1	497321.C664_19630	3.13e-55	177.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2VQ2M@28216|Betaproteobacteria,2KWIS@206389|Rhodocyclales	206389|Rhodocyclales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_195727_1	987059.RBXJA2T_12202	1.23e-43	156.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,1KKBU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_195727_2	580332.Slit_1833	2.28e-43	151.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria,44WDD@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase GroES domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1011117_1	1166948.JPZL01000002_gene1215	2.55e-68	222.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XJ03@135619|Oceanospirillales	135619|Oceanospirillales	P	Trk system potassium uptake protein	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_795633_1	335283.Neut_1808	4.68e-65	219.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,37235@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM glycosyl transferase, family 51	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_795633_2	1163617.SCD_n02941	8.86e-20	88.6	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_1011119_1	269796.Rru_A0360	6.46e-16	77.4	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,2JQQJ@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_456251_1	666684.AfiDRAFT_1915	1.02e-51	181.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TUYS@28211|Alphaproteobacteria,3JRDP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	MA20_25925	-	2.7.13.3	ko:K07716	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_1011127_1	1120999.JONM01000002_gene951	4.48e-42	145.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	cmk	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase,Cytidylate_kin
k59_64971_1	234267.Acid_0583	2.81e-12	67.8	COG3191@1|root,COG3191@2|Bacteria,3Y6EN@57723|Acidobacteria	57723|Acidobacteria	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
k59_64971_2	671143.DAMO_0089	1.64e-22	88.2	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_540631_1	153948.NAL212_2412	1.41e-58	201.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,372CB@32003|Nitrosomonadales	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_880967_1	1211114.ALIP01000099_gene1885	6.94e-06	47.8	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1S6G7@1236|Gammaproteobacteria,1X6FR@135614|Xanthomonadales	135614|Xanthomonadales	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_880967_2	414684.RC1_1718	1.11e-76	243.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales	204441|Rhodospirillales	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_912451_1	439235.Dalk_0710	1.27e-47	162.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MI6F@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_912451_2	1304885.AUEY01000028_gene2790	8.71e-146	419.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2WIXY@28221|Deltaproteobacteria,2MHNK@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1844	AIRS,AIRS_C
k59_195770_1	1415630.U771_05062	9.82e-19	90.1	2DMKC@1|root,32S64@2|Bacteria,1N3QF@1224|Proteobacteria,1S8NZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3
k59_195770_2	525373.HMPREF0766_14337	1.11e-104	306.0	COG1961@1|root,COG1961@2|Bacteria,4NJM8@976|Bacteroidetes,1ITQV@117747|Sphingobacteriia	976|Bacteroidetes	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,Resolvase
k59_419861_1	1417296.U879_01200	7.44e-18	87.0	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2TTBR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	MA20_23245	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_195775_1	1385517.N800_03270	5.07e-73	235.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RMUK@1236|Gammaproteobacteria,1X40E@135614|Xanthomonadales	135614|Xanthomonadales	P	Nitrate nitrite transporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_1011153_1	301.JNHE01000009_gene3304	7.41e-111	338.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,1RPNW@1236|Gammaproteobacteria,1YDMH@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	L-lactate permease	lldP	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
k59_880994_1	909663.KI867150_gene908	2.83e-24	106.0	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,42M50@68525|delta/epsilon subdivisions,2WIP4@28221|Deltaproteobacteria,2MQYM@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_228083_1	1532557.JL37_10315	5.32e-10	60.1	COG0028@1|root,COG0028@2|Bacteria,1R6FF@1224|Proteobacteria,2WF6X@28216|Betaproteobacteria,3T1CR@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_228083_2	94624.Bpet0414	3.26e-233	647.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VK3Y@28216|Betaproteobacteria,3T6WH@506|Alcaligenaceae	28216|Betaproteobacteria	G	D-galactarate dehydratase	-	-	4.2.1.7,4.4.1.24	ko:K16846,ko:K16850	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
k59_390981_1	1123376.AUIU01000013_gene1796	3.13e-21	96.3	COG0750@1|root,COG0750@2|Bacteria,3J0GI@40117|Nitrospirae	40117|Nitrospirae	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
k59_65029_1	765911.Thivi_4543	1.61e-23	106.0	COG0515@1|root,COG1262@1|root,COG2909@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG2909@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria,1X2K2@135613|Chromatiales	135613|Chromatiales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,Pkinase
k59_195806_1	1111732.AZOD01000001_gene1546	5.94e-08	53.1	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1X58Z@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_195806_2	1125863.JAFN01000001_gene568	6.94e-61	201.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
k59_1011176_1	987059.RBXJA2T_07145	4.36e-38	132.0	COG3152@1|root,COG3152@2|Bacteria,1QECM@1224|Proteobacteria,2VXXF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF805
k59_1011176_2	189425.PGRAT_13805	1.66e-08	53.9	COG0454@1|root,COG0456@2|Bacteria,1UI4D@1239|Firmicutes,4HX00@91061|Bacilli,26X6W@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase	ysnE	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_391000_1	1279015.KB908459_gene2688	1.63e-24	105.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1Y400@135624|Aeromonadales	135624|Aeromonadales	T	Nitrogen regulation protein NR(II)	glnL	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
k59_65046_2	1128421.JAGA01000003_gene3564	5.07e-44	153.0	COG1216@1|root,COG1216@2|Bacteria,2NNYJ@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl transferase family 2	dpm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_1028375_1	279714.FuraDRAFT_2279	4.32e-103	309.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,2KRDG@206351|Neisseriales	206351|Neisseriales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1029984_2	314345.SPV1_13914	4.26e-13	68.9	COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria	1224|Proteobacteria	S	PeriplasmiC protein	lapF	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
k59_543870_1	1288494.EBAPG3_600	1.75e-72	229.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,371RC@32003|Nitrosomonadales	28216|Betaproteobacteria	E	PFAM Aminotransferase, class V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_259472_1	1189612.A33Q_2828	5.89e-12	72.0	COG2866@1|root,COG2866@2|Bacteria,4NF3D@976|Bacteroidetes,47MVZ@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_487598_1	204669.Acid345_1270	1.39e-196	565.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
k59_1029985_1	1150599.MPHLEI_27062	3.61e-62	202.0	COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria,23402@1762|Mycobacteriaceae	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_1029985_2	298655.KI912266_gene3948	5.35e-18	82.8	COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria,4EUJC@85013|Frankiales	201174|Actinobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_782275_1	1123060.JONP01000046_gene5301	1.62e-47	170.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,2JWQZ@204441|Rhodospirillales	204441|Rhodospirillales	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_423156_1	251221.35211835	1.64e-12	70.5	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_423156_2	234267.Acid_6481	2.74e-11	63.5	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_284943_1	580332.Slit_0824	5.02e-95	290.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VNWB@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM aminotransferase class V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_487655_1	261292.Nit79A3_3118	9.62e-105	328.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,371QF@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_423246_1	1121405.dsmv_0150	1.83e-79	244.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2WKMR@28221|Deltaproteobacteria,2MIXA@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_259565_1	1267535.KB906767_gene2153	1.7e-05	49.3	COG0842@1|root,COG1228@1|root,COG0842@2|Bacteria,COG1228@2|Bacteria,3Y750@57723|Acidobacteria	57723|Acidobacteria	QV	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,Amidohydro_1
k59_543986_1	1163617.SCD_n01166	2.2e-66	210.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_423260_1	1235457.C404_08770	9.26e-101	305.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,1K0TV@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_487716_1	387631.Asulf_01706	9.16e-56	179.0	COG1814@1|root,arCOG01096@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_487724_1	1031711.RSPO_c02160	4.09e-48	172.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,1K251@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_782390_2	177439.DP3005	3.09e-103	306.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42PNX@68525|delta/epsilon subdivisions,2WK8F@28221|Deltaproteobacteria,2MJU9@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_822360_1	365044.Pnap_3108	6.82e-52	174.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VK20@28216|Betaproteobacteria,4AJA5@80864|Comamonadaceae	28216|Betaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_724280_1	1038859.AXAU01000013_gene6462	2.32e-50	162.0	2BSW3@1|root,32MZQ@2|Bacteria,1RB9D@1224|Proteobacteria,2U9SS@28211|Alphaproteobacteria,3JZH5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Family of unknown function (DUF5413)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5413
k59_952745_2	1219035.NT2_02_05190	8.51e-23	98.2	COG1335@1|root,COG1335@2|Bacteria,1QK2B@1224|Proteobacteria,2U5X9@28211|Alphaproteobacteria,2K43F@204457|Sphingomonadales	204457|Sphingomonadales	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_755767_1	1126627.BAWE01000004_gene2799	3.37e-111	331.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,2TRU1@28211|Alphaproteobacteria,3JQR0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	mdoG	GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:1901576	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
k59_332382_2	56780.SYN_01092	3.12e-91	273.0	COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,42PJH@68525|delta/epsilon subdivisions,2WMZT@28221|Deltaproteobacteria,2MRMS@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	TrkA-N domain	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_822381_1	262724.TT_C1163	1.75e-09	65.1	COG0604@1|root,COG0604@2|Bacteria,1WI1Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG0604 NADPH quinone reductase and related Zn-dependent	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_854533_1	375451.RD1_3788	1.64e-53	181.0	COG0673@1|root,COG0673@2|Bacteria,1MW74@1224|Proteobacteria,2TSFH@28211|Alphaproteobacteria,2P1ES@2433|Roseobacter	28211|Alphaproteobacteria	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_854533_2	420324.KI912010_gene8961	6.51e-17	80.1	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2TS85@28211|Alphaproteobacteria,1JSJA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	2.7.1.217	ko:K21948	-	-	R11706,R11707	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
k59_71513_1	1121033.AUCF01000010_gene4576	5.45e-101	315.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria,2JPVC@204441|Rhodospirillales	204441|Rhodospirillales	G	Malonyl-CoA decarboxylase N-terminal domain	-	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
k59_299391_1	395019.Bmul_4820	5.58e-140	416.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,1K2IB@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_6060_1	1430440.MGMSRv2_2525	3.3e-26	100.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,2JPS1@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the GST superfamily	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_N,GST_N_3
k59_561166_1	1379698.RBG1_1C00001G0623	7.38e-43	148.0	COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	ybhF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_561166_2	497964.CfE428DRAFT_4552	6.24e-40	141.0	COG1566@1|root,COG1566@2|Bacteria,46V9F@74201|Verrucomicrobia	74201|Verrucomicrobia	V	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
k59_495991_2	795666.MW7_0756	1.85e-22	99.0	COG0845@1|root,COG0845@2|Bacteria,1RGVI@1224|Proteobacteria,2WEMG@28216|Betaproteobacteria,1K3FZ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_332403_1	671143.DAMO_1101	9.06e-17	83.6	COG0581@1|root,COG0581@2|Bacteria,2NPJS@2323|unclassified Bacteria	2|Bacteria	P	phosphate transport system permease protein	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_332403_2	1415779.JOMH01000001_gene1378	2.3e-16	79.0	COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,1T1GK@1236|Gammaproteobacteria,1XDHG@135614|Xanthomonadales	135614|Xanthomonadales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_854553_1	987059.RBXJA2T_10474	2.33e-91	276.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,1KIXQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
k59_233617_1	1366050.N234_10650	0.000421	42.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VM0F@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_233617_2	469381.Dpep_0655	3.41e-41	153.0	COG3181@1|root,COG3181@2|Bacteria,3TC72@508458|Synergistetes	508458|Synergistetes	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_201806_1	1448389.BAVQ01000011_gene3958	3.33e-15	80.1	COG0160@1|root,COG0160@2|Bacteria,2GIS9@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_495992_1	292415.Tbd_2727	2.86e-114	352.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2VKKI@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_299416_1	247633.GP2143_07474	4.8e-113	342.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_920349_1	96561.Dole_3043	6.11e-57	180.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,2MJW2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_920349_2	1285586.H131_16143	1.75e-09	53.9	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,4HNIQ@91061|Bacilli,3IYJB@400634|Lysinibacillus	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_364820_1	1217718.ALOU01000016_gene3272	7.88e-130	377.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,1K1ZY@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_38657_1	1105031.HMPREF1141_0283	0.000933	45.8	COG1309@1|root,COG1309@2|Bacteria,1VCGN@1239|Firmicutes,24T8E@186801|Clostridia,36KWI@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_6085_2	945713.IALB_2427	4.77e-47	163.0	COG5557@1|root,COG5557@2|Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	hmcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	NrfD
k59_71550_1	1499967.BAYZ01000056_gene4882	2.3e-30	122.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,PEP_hydrolase,Sigma54_activat
k59_71551_1	1163617.SCD_n01951	4.68e-84	271.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	type II secretion system protein E	-	-	-	ko:K02454,ko:K02652,ko:K12276	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GAF,T2SSE,T2SSE_N
k59_593695_1	1218084.BBJK01000105_gene6541	4.67e-90	278.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VHC1@28216|Betaproteobacteria,1K09M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520,ko:K21739	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_201826_1	998088.B565_0466	1.63e-51	166.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,1S45S@1236|Gammaproteobacteria,1Y4HC@135624|Aeromonadales	135624|Aeromonadales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_201826_2	1158760.AQXP01000053_gene1380	4.26e-25	103.0	COG0596@1|root,COG0596@2|Bacteria,1RJQK@1224|Proteobacteria,1SAH5@1236|Gammaproteobacteria,1X142@135613|Chromatiales	135613|Chromatiales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_985077_1	383372.Rcas_2866	6.91e-20	89.0	COG4974@1|root,COG4974@2|Bacteria,2G7RJ@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_952797_1	94624.Bpet4183	7.45e-29	105.0	COG3293@1|root,COG3293@2|Bacteria,1N0VW@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_952797_2	358220.C380_11715	7.43e-69	213.0	COG3293@1|root,COG3293@2|Bacteria,1N8GF@1224|Proteobacteria,2WESM@28216|Betaproteobacteria,4AJPE@80864|Comamonadaceae	28216|Betaproteobacteria	L	COG3293 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_103985_1	1454004.AW11_03569	3.14e-96	289.0	COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,2VKYT@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Pseudouridine synthase	truC	-	5.4.99.26	ko:K06175	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_2
k59_985079_1	76114.ebA4794	1.6e-95	296.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KVAY@206389|Rhodocyclales	206389|Rhodocyclales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_267216_1	398525.KB900701_gene5174	1.09e-61	194.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,3JR9A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_300289_2	439235.Dalk_4744	8.8e-61	202.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,2MICX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_431009_1	649638.Trad_0147	6.98e-96	305.0	COG1048@1|root,COG1048@2|Bacteria,1WIMG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acn	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_333343_1	391735.Veis_1429	7.2e-32	123.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4AHEG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_725295_1	497321.C664_09095	1.39e-109	349.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,2KUZA@206389|Rhodocyclales	206389|Rhodocyclales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_985964_1	228410.NE0356	1.47e-65	207.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,372UA@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_985964_2	1131553.JIBI01000001_gene1501	1.29e-07	52.4	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,372DK@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Ribonuclease E/G family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_887811_1	1121405.dsmv_2116	5.59e-74	225.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,42SDX@68525|delta/epsilon subdivisions,2WP41@28221|Deltaproteobacteria,2MK62@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_921318_1	522306.CAP2UW1_1940	1.41e-103	315.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,2VJQH@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_887814_1	1068980.ARVW01000001_gene4752	4.84e-21	92.4	COG1024@1|root,COG1024@2|Bacteria,2HHR6@201174|Actinobacteria,4DXU9@85010|Pseudonocardiales	201174|Actinobacteria	I	enoyl-CoA hydratase	Echdc	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_887814_2	1268622.AVS7_02980	2.12e-22	96.7	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,4AAG0@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_756459_1	869213.JCM21142_257	6.29e-34	132.0	COG0466@1|root,COG0466@2|Bacteria,4NE1G@976|Bacteroidetes,47M84@768503|Cytophagia	976|Bacteroidetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_985984_1	436308.Nmar_0190	1.22e-26	102.0	COG0500@1|root,arCOG01773@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
k59_202753_1	986075.CathTA2_3008	2.42e-88	275.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,4HAIS@91061|Bacilli	91061|Bacilli	L	ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_527452_1	420662.Mpe_A3262	1.74e-48	167.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,1KJH9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_527452_2	1051006.HMPREF1162_0361	6.39e-13	66.2	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4DQJU@85009|Propionibacteriales	201174|Actinobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_72535_1	717773.Thicy_0002	1.21e-11	65.5	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,4601X@72273|Thiotrichales	72273|Thiotrichales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_72535_2	393595.ABO_0001	1.72e-13	69.3	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1XHHN@135619|Oceanospirillales	135619|Oceanospirillales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_953824_1	575540.Isop_2274	2.38e-10	58.9	COG2363@1|root,COG2363@2|Bacteria,2J0QQ@203682|Planctomycetes	203682|Planctomycetes	S	small membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
k59_756464_1	1226322.HMPREF1545_01557	1.15e-12	69.7	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,2N6EJ@216572|Oscillospiraceae	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_756464_2	330214.NIDE0369	1.57e-62	196.0	COG0712@1|root,COG0712@2|Bacteria,3J1BY@40117|Nitrospirae	40117|Nitrospirae	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_496973_1	1340493.JNIF01000003_gene2249	3.45e-08	55.8	COG1309@1|root,COG1309@2|Bacteria,3Y4ER@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_13,TetR_N
k59_104951_1	1458357.BG58_07285	3.59e-96	293.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2VMN7@28216|Betaproteobacteria,1K3PN@119060|Burkholderiaceae	28216|Betaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	-	1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81	ko:K00015,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R00717,R01388,R01392,R01739	RC00031,RC00042,RC00084	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_431052_1	399739.Pmen_2167	1.17e-51	181.0	COG2010@1|root,COG2010@2|Bacteria,1MVYK@1224|Proteobacteria,1RQH2@1236|Gammaproteobacteria,1YEVD@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_887847_1	1121405.dsmv_0499	1.98e-51	177.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MIF0@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0470	CPT,CbiA,GATase_3
k59_887847_2	156889.Mmc1_3134	6.92e-11	61.2	COG2082@1|root,COG2082@2|Bacteria,1MX1E@1224|Proteobacteria,2TRRB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Precorrin-8X methylmutase	cobH	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiC
k59_1015123_1	1163617.SCD_n02012	1.7e-92	285.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_462674_1	335543.Sfum_2956	9.19e-96	301.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,2MQ9F@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_692860_1	357808.RoseRS_0426	2.25e-11	63.5	COG1825@1|root,COG1825@2|Bacteria,2G6YX@200795|Chloroflexi,375RP@32061|Chloroflexia	32061|Chloroflexia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_692860_2	1089544.KB912942_gene5210	4.76e-07	51.2	COG0745@1|root,COG0745@2|Bacteria,2GJRR@201174|Actinobacteria,4DYIR@85010|Pseudonocardiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_365802_1	926550.CLDAP_00560	4.87e-51	180.0	COG2373@1|root,COG2373@2|Bacteria,2G5XN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1
k59_72550_2	933262.AXAM01000013_gene1334	1.09e-39	137.0	COG1848@1|root,COG1848@2|Bacteria,1NY2U@1224|Proteobacteria,430C7@68525|delta/epsilon subdivisions,2WW5R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_72550_3	237368.SCABRO_03923	1.48e-12	63.9	COG2002@1|root,COG2002@2|Bacteria,2J3S7@203682|Planctomycetes	203682|Planctomycetes	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
k59_921375_1	436308.Nmar_1790	2.68e-38	139.0	COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_921375_2	1229909.NSED_09580	2.16e-88	263.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
k59_431071_1	257310.BB1746	6.62e-17	83.6	COG2267@1|root,COG2267@2|Bacteria,1MVAI@1224|Proteobacteria,2VVKH@28216|Betaproteobacteria	28216|Betaproteobacteria	I	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation	rutD	-	-	ko:K09023	ko00240,ko01100,map00240,map01100	-	R09983	RC02769	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_365811_1	1123060.JONP01000032_gene1847	2.11e-15	78.2	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JSUV@204441|Rhodospirillales	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_365811_2	1125973.JNLC01000011_gene582	6.27e-27	103.0	COG1917@1|root,COG1917@2|Bacteria,1MYMN@1224|Proteobacteria,2UR93@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_333411_1	1205908.AKXW01000108_gene1252	3.12e-141	409.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,1RNSQ@1236|Gammaproteobacteria,1XU5I@135623|Vibrionales	135623|Vibrionales	E	Belongs to the group II decarboxylase family	gadB	GO:0003674,GO:0003824,GO:0004351,GO:0006082,GO:0006520,GO:0006536,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
k59_594696_1	1469607.KK073768_gene4812	5.21e-36	128.0	COG3415@1|root,COG3415@2|Bacteria,1GFZ6@1117|Cyanobacteria	1117|Cyanobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_594696_2	1469607.KK073768_gene3310	1.01e-11	62.8	COG3335@1|root,COG3335@2|Bacteria,1G5W5@1117|Cyanobacteria,1HSB3@1161|Nostocales	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_636118_1	1267534.KB906758_gene2484	2.72e-14	71.6	COG2010@1|root,COG2010@2|Bacteria,3Y2FX@57723|Acidobacteria,2JINQ@204432|Acidobacteriia	204432|Acidobacteriia	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460,Haem_bd
k59_506119_1	857087.Metme_4591	0.000125	44.3	2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,1SDBT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
k59_506119_2	1237149.C900_00064	0.000886	45.8	COG4251@1|root,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_9,Reg_prop,Response_reg,Y_Y_Y
k59_342351_1	292415.Tbd_1860	4.54e-102	303.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,1KRES@119069|Hydrogenophilales	119069|Hydrogenophilales	IM	LytB protein	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_702317_1	261292.Nit79A3_3381	1.12e-126	395.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales	28216|Betaproteobacteria	CEH	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_374471_1	318161.Sden_3424	1.19e-52	188.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q8ZG@267890|Shewanellaceae	1236|Gammaproteobacteria	T	Two component regulator three Y domain protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_9,Reg_prop,Y_Y_Y
k59_832859_2	945713.IALB_0312	1.18e-46	161.0	COG1219@1|root,COG1219@2|Bacteria	2|Bacteria	O	unfolded protein binding	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_16388_1	1042876.PPS_2397	2.75e-31	115.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria	1224|Proteobacteria	K	amidohydrolase	bamU	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_16388_2	1323361.JPOC01000048_gene399	1.9e-22	93.6	2CJXB@1|root,2ZIFC@2|Bacteria,2H9YF@201174|Actinobacteria,4G6W7@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_994804_1	1216976.AX27061_6046	1.07e-35	135.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,3T2FH@506|Alcaligenaceae	28216|Betaproteobacteria	P	Sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_994804_2	365044.Pnap_0869	2.65e-89	277.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_832866_1	330214.NIDE3976	7.87e-60	191.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3,Thioredoxin_4
k59_1019838_1	1131553.JIBI01000004_gene391	0.000658	41.6	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2VMPA@28216|Betaproteobacteria,37223@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	PFAM Methionine biosynthesis MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
k59_1019838_2	335283.Neut_0528	2.1e-78	244.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,371VZ@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metXS	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_211583_1	325452.fgenesh_scip_prom.46568.6658	6.76e-15	73.2	2D6ED@1|root,2S56W@2759|Eukaryota,3QFVE@4776|Peronosporales	4776|Peronosporales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_763977_1	1340493.JNIF01000003_gene3310	9.32e-26	104.0	COG3279@1|root,COG3279@2|Bacteria,3Y3HR@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_211587_1	234267.Acid_4184	9.53e-40	147.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3Y37Y@57723|Acidobacteria	57723|Acidobacteria	E	Vitamin B12 dependent methionine synthase activation	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_832880_1	436308.Nmar_0382	2.04e-91	272.0	COG0081@1|root,arCOG04289@2157|Archaea,41SHF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_1019841_1	580332.Slit_0536	1.13e-73	243.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,44VNC@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	General secretory system II protein E domain protein	-	-	-	ko:K02454,ko:K02652,ko:K12276	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GAF,T2SSE,T2SSE_N
k59_16405_1	1266925.JHVX01000016_gene179	1.22e-46	157.0	COG0524@1|root,COG0524@2|Bacteria,1PDQE@1224|Proteobacteria,2VHMF@28216|Betaproteobacteria,372FP@32003|Nitrosomonadales	28216|Betaproteobacteria	H	pfkB family carbohydrate kinase	adoK	-	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100	-	R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_308690_1	864563.HMPREF9166_2267	6.45e-15	79.3	COG0535@1|root,COG0535@2|Bacteria,1VD3I@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_669552_1	330214.NIDE3256	1.53e-142	410.0	COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae	2|Bacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ddhB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.5.1	ko:K00371,ko:K16965,ko:K17048,ko:K17051	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9	-	-	Fer4_11
k59_81795_1	265072.Mfla_0682	6.73e-111	329.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VJ2B@28216|Betaproteobacteria,2KM5I@206350|Nitrosomonadales	206350|Nitrosomonadales	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_636159_1	99598.Cal7507_3848	2.29e-50	174.0	COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,1HMN9@1161|Nostocales	1117|Cyanobacteria	GM	ABC-type polysaccharide polyol phosphate transport system ATPase component	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
k59_896427_1	436308.Nmar_0450	2e-28	108.0	COG1676@1|root,arCOG01701@2157|Archaea,41SJY@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
k59_896427_2	436308.Nmar_0213	1.16e-39	132.0	arCOG10521@1|root,arCOG10521@2157|Archaea,41T8A@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_439786_1	338969.Rfer_3082	1.96e-57	185.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VM61@28216|Betaproteobacteria,4A9SU@80864|Comamonadaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_16431_2	1123392.AQWL01000007_gene959	2.31e-23	94.7	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2VTY7@28216|Betaproteobacteria,1KT9W@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Copper chaperone PCu(A)C	-	-	-	-	-	-	-	-	-	-	-	-	PCuAC
k59_49661_2	983917.RGE_45300	1.11e-25	109.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,1KJ74@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_637168_1	1323663.AROI01000016_gene525	8.36e-190	546.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Gamma-glutamyltransferase	ggt1	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_507242_1	391615.ABSJ01000026_gene121	2.63e-88	273.0	2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_375563_1	998674.ATTE01000001_gene3608	1.12e-12	68.6	COG3386@1|root,COG3386@2|Bacteria,1QN8Y@1224|Proteobacteria,1S5PU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_532639_1	159087.Daro_2836	6.41e-52	177.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KVIV@206389|Rhodocyclales	206389|Rhodocyclales	M	lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_532639_2	323848.Nmul_A2508	4.86e-06	47.8	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,372YT@32003|Nitrosomonadales	28216|Betaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_833998_1	999541.bgla_1g02630	7.99e-73	224.0	COG0461@1|root,COG0461@2|Bacteria,1MVP7@1224|Proteobacteria,2VSR8@28216|Betaproteobacteria,1K1C7@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_865485_1	1280390.CBQR020000071_gene1484	8.92e-105	326.0	COG0577@1|root,COG0577@2|Bacteria,1TQ3S@1239|Firmicutes,4HCJ4@91061|Bacilli,26RXF@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_764976_1	1047013.AQSP01000139_gene2352	2.2e-51	184.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
k59_309659_1	228410.NE0771	9.14e-38	142.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,3722S@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Tetratricopeptide repeat	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
k59_17508_1	945713.IALB_2613	4.93e-62	195.0	COG1392@1|root,COG1392@2|Bacteria	2|Bacteria	P	Protein of unknown function DUF47	MA20_27875	-	-	ko:K02039,ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_507259_1	745014.OMB55_00020910	4.22e-34	129.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1J4ZP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_49683_1	1366050.N234_20040	4.79e-52	178.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VIGB@28216|Betaproteobacteria,1KD54@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_405975_1	243233.MCA2607	2.33e-111	341.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,1RMG4@1236|Gammaproteobacteria,1XDRS@135618|Methylococcales	135618|Methylococcales	T	Carbon starvation protein CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
k59_405975_2	1122236.KB905141_gene1815	9.18e-10	55.1	COG2879@1|root,COG2879@2|Bacteria,1NQ41@1224|Proteobacteria,2WFEQ@28216|Betaproteobacteria,2KN8N@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Selenoprotein, putative	-	-	-	-	-	-	-	-	-	-	-	-	Sel_put
k59_115186_1	1297570.MESS4_170003	1.57e-10	62.8	COG3181@1|root,COG3181@2|Bacteria,1PGZ7@1224|Proteobacteria,2V8QA@28211|Alphaproteobacteria,43QSJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_115186_2	1266998.ATUJ01000003_gene1551	5.62e-18	85.5	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,2PUXM@265|Paracoccus	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA,TctB
k59_964352_1	1041138.KB890258_gene2873	1.39e-99	305.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria,4BAZE@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_532649_1	686340.Metal_0315	3.97e-43	162.0	COG2319@1|root,COG2372@1|root,COG2319@2|Bacteria,COG2372@2|Bacteria,1MWJA@1224|Proteobacteria,1S1AJ@1236|Gammaproteobacteria,1XF66@135618|Methylococcales	135618|Methylococcales	N	WD40 repeat, subgroup	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,WD40
k59_764997_1	1217718.ALOU01000005_gene1447	7.01e-148	425.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,1JZRA@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_995948_1	1158762.KB898048_gene671	2.02e-98	300.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1SEJ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored,GIDA,Lycopene_cycl
k59_180407_1	426114.THI_3367	6.26e-65	212.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,1KJ18@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_343512_1	1458275.AZ34_09600	7.86e-23	98.6	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,4AD7T@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,EAL,GGDEF,HAMP,MASE1,PAS,PAS_3,PAS_4,PAS_8,PAS_9
k59_343512_2	1157708.KB907450_gene6083	1.58e-33	117.0	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,2VTYU@28216|Betaproteobacteria,4AEC5@80864|Comamonadaceae	28216|Betaproteobacteria	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	yggX	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
k59_834030_1	436308.Nmar_0616	1.79e-101	327.0	arCOG08231@1|root,arCOG08231@2157|Archaea,41T6Q@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	LTD
k59_637212_1	1267005.KB911265_gene3604	7.03e-07	49.7	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2UFPB@28211|Alphaproteobacteria,3N7EH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	HPr Serine kinase C-terminal domain	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C
k59_637212_2	1437448.AZRT01000037_gene3227	7.92e-42	155.0	COG5002@1|root,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,2TWBW@28211|Alphaproteobacteria,1J2AA@118882|Brucellaceae	28211|Alphaproteobacteria	T	Stimulus-sensing domain	chvG	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
k59_147920_1	269799.Gmet_0813	1.68e-54	186.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,43SBZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
k59_931791_1	562970.Btus_1426	7.41e-46	171.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,277VY@186823|Alicyclobacillaceae	91061|Bacilli	KLT	Serine/Threonine protein kinases, catalytic domain	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_180414_1	335543.Sfum_2646	9.58e-69	222.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria,2MRDY@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_572561_2	243233.MCA0774	4.26e-13	70.9	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1XEE4@135618|Methylococcales	135618|Methylococcales	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
k59_440869_1	1279017.AQYJ01000019_gene1516	4.38e-30	116.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,46691@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_440869_2	717773.Thicy_1125	9e-15	73.9	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,45ZNG@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_604822_1	716544.wcw_0789	1.86e-23	99.8	COG0095@1|root,COG0095@2|Bacteria,2JG15@204428|Chlamydiae	204428|Chlamydiae	H	Biotin/lipoate A/B protein ligase family	lplA_1	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_82931_1	1462527.CCDM010000003_gene3982	2.06e-20	94.4	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,4HBCE@91061|Bacilli,23JT8@182709|Oceanobacillus	91061|Bacilli	M	Penicillin-binding protein 5, C-terminal domain	dacF	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_789375_1	1304883.KI912532_gene2260	1.55e-35	127.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales	206389|Rhodocyclales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_789375_2	1266925.JHVX01000009_gene80	1.61e-57	191.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,37224@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase,HTH_6,SIS
k59_440880_1	1485544.JQKP01000001_gene933	2.32e-06	48.1	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,44UZR@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_834052_1	1379698.RBG1_1C00001G0346	6.92e-62	201.0	COG0341@1|root,COG0341@2|Bacteria,2NP4P@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_17554_1	1163617.SCD_n02200	2.19e-117	351.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria	28216|Betaproteobacteria	U	SMART AAA ATPase	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_147939_1	1268068.PG5_61530	5.73e-39	138.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	polyphosphate kinase	ppk2	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_147939_2	1458357.BG58_09870	3.27e-52	180.0	COG1538@1|root,COG1538@2|Bacteria,1REC6@1224|Proteobacteria,2VZ9S@28216|Betaproteobacteria,1KBKV@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_964397_1	1411123.JQNH01000001_gene503	3.56e-77	250.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_212751_1	886293.Sinac_2356	6.02e-14	74.7	COG1215@1|root,COG1215@2|Bacteria,2J02Q@203682|Planctomycetes	203682|Planctomycetes	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_765032_1	330214.NIDE0860	6.99e-86	281.0	COG1196@1|root,COG1196@2|Bacteria,3J0W4@40117|Nitrospirae	40117|Nitrospirae	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
k59_677867_1	335283.Neut_0207	1.27e-48	156.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2VSKJ@28216|Betaproteobacteria,373D1@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_903928_1	1121439.dsat_1636	1.63e-93	284.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2WJX5@28221|Deltaproteobacteria,2MA0E@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_122062_1	945713.IALB_0490	1.69e-80	266.0	COG0784@1|root,COG2202@1|root,COG4251@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	luxN	-	2.7.13.3	ko:K15850	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_872361_1	1485544.JQKP01000002_gene1412	5.92e-49	162.0	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria,44VSN@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
k59_611672_2	1121127.JAFA01000031_gene4654	5.79e-34	129.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VJ40@28216|Betaproteobacteria,1K4VW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_677872_1	1026882.MAMP_01424	3.42e-26	107.0	COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,1RSI6@1236|Gammaproteobacteria,463PE@72273|Thiotrichales	72273|Thiotrichales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_938886_1	396588.Tgr7_2124	3.36e-18	89.4	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales	135613|Chromatiales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_350356_1	1121405.dsmv_3225	5.21e-139	415.0	COG0031@1|root,COG0215@1|root,COG0031@2|Bacteria,COG0215@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,2MIN1@213118|Desulfobacterales	28221|Deltaproteobacteria	J	cysteinyl-tRNA synthetase	cysM	-	2.5.1.47,6.1.1.16	ko:K01738,ko:K01883,ko:K12339	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,PALP,tRNA-synt_1e
k59_219421_1	641491.DND132_1546	6.73e-116	344.0	COG0247@1|root,COG0247@2|Bacteria,1R467@1224|Proteobacteria,42NIQ@68525|delta/epsilon subdivisions,2WIUU@28221|Deltaproteobacteria,2MGJ7@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hmcF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17
k59_248742_2	1120949.KB903357_gene4895	1.14e-74	242.0	COG0028@1|root,COG0028@2|Bacteria,2I9V6@201174|Actinobacteria	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_644979_2	436308.Nmar_0345	1.29e-26	105.0	arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota	651137|Thaumarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_249583_1	1121405.dsmv_3644	3.17e-88	290.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MIYJ@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_249583_2	933262.AXAM01000079_gene2200	4.36e-25	97.1	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,42RDQ@68525|delta/epsilon subdivisions,2WND8@28221|Deltaproteobacteria,2MJVJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k59_477868_1	401053.AciPR4_0206	2.17e-30	124.0	COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,3Y3YU@57723|Acidobacteria,2JIXB@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Reg_prop,Y_Y_Y
k59_678859_1	1384056.N787_08795	5.45e-62	204.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1X34E@135614|Xanthomonadales	135614|Xanthomonadales	E	aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_711627_1	1123008.KB905701_gene2172	4.05e-15	81.6	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia,22XI5@171551|Porphyromonadaceae	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_580697_1	330214.NIDE0827	6.45e-171	486.0	COG0674@1|root,COG0674@2|Bacteria,3J105@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_412921_2	335543.Sfum_0648	3.52e-55	177.0	COG2204@1|root,COG2204@2|Bacteria,1RKC4@1224|Proteobacteria,42SJ3@68525|delta/epsilon subdivisions,2WPI1@28221|Deltaproteobacteria,2MRU7@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_972534_1	709797.CSIRO_1973	7.99e-26	106.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,3JRNY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_972534_2	1211115.ALIQ01000198_gene446	9.01e-28	110.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3NC6F@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.39	ko:K00128,ko:K00146	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_448452_1	56107.Cylst_1537	7.12e-05	46.2	COG3170@1|root,COG3170@2|Bacteria,1G6DU@1117|Cyanobacteria,1HN5Y@1161|Nostocales	1117|Cyanobacteria	NU	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
k59_904878_1	1038867.AXAY01000022_gene2806	4.53e-18	84.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,3JSHP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_612642_1	95619.PM1_0216340	2.56e-42	160.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_412932_1	1123393.KB891316_gene1630	4.95e-71	240.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KSAB@119069|Hydrogenophilales	119069|Hydrogenophilales	V	Patched family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_351314_1	387092.NIS_1536	1.69e-17	80.5	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2YMQW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_351314_2	945713.IALB_0698	3.51e-103	308.0	COG0052@1|root,COG0052@2|Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_477900_2	999541.bgla_1g36700	4.16e-119	349.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,1K0VT@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_279020_1	1266925.JHVX01000004_gene1185	8.04e-100	297.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2VHYC@28216|Betaproteobacteria,371MW@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	potB	-	-	ko:K02054,ko:K11071	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	BPD_transp_1
k59_155821_1	204773.HEAR1431	2.6e-35	124.0	COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,2VUWN@28216|Betaproteobacteria,474VE@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Invasion gene expression up-regulator, SirB	sirB	-	-	-	-	-	-	-	-	-	-	-	SirB
k59_155821_2	1244869.H261_06576	2.03e-67	219.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales	204441|Rhodospirillales	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_972562_1	29581.BW37_05245	1.72e-126	369.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4730X@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_939870_1	1266925.JHVX01000001_gene2483	7.77e-145	421.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_939870_2	1244869.H261_06576	3.42e-123	374.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales	204441|Rhodospirillales	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_678901_1	330214.NIDE0228	1.78e-26	108.0	COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae	40117|Nitrospirae	CP	NADH-quinone oxidoreductase	-	-	1.6.5.3	ko:K00341,ko:K05568,ko:K12139	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_477903_1	502025.Hoch_2631	1.64e-113	344.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,42QCJ@68525|delta/epsilon subdivisions,2WKE7@28221|Deltaproteobacteria,2YUF8@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	DUF547,Glyco_hydro_15
k59_249623_1	105559.Nwat_1995	1.22e-09	58.9	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1WWRR@135613|Chromatiales	135613|Chromatiales	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_249623_2	244447.XP_008318269.1	1.34e-26	107.0	COG0005@1|root,KOG3984@2759|Eukaryota,38BI3@33154|Opisthokonta,3BDDV@33208|Metazoa,3CUH9@33213|Bilateria,47ZIF@7711|Chordata,48XWD@7742|Vertebrata,49U2I@7898|Actinopterygii	33208|Metazoa	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	PNP	GO:0001775,GO:0001816,GO:0001882,GO:0001910,GO:0001912,GO:0001914,GO:0001916,GO:0002054,GO:0002060,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002682,GO:0002684,GO:0002694,GO:0002696,GO:0002697,GO:0002699,GO:0002703,GO:0002705,GO:0002706,GO:0002708,GO:0002709,GO:0002711,GO:0002790,GO:0002819,GO:0002821,GO:0002822,GO:0002824,GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006148,GO:0006149,GO:0006152,GO:0006161,GO:0006163,GO:0006164,GO:0006183,GO:0006195,GO:0006282,GO:0006725,GO:0006732,GO:0006733,GO:0006738,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006915,GO:0006950,GO:0006955,GO:0006974,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0008219,GO:0008284,GO:0008617,GO:0008630,GO:0008637,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009120,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009151,GO:0009152,GO:0009163,GO:0009164,GO:0009165,GO:0009166,GO:0009199,GO:0009200,GO:0009201,GO:0009205,GO:0009206,GO:0009215,GO:0009259,GO:0009260,GO:0009262,GO:0009306,GO:0009314,GO:0009394,GO:0009435,GO:0009628,GO:0009893,GO:0009987,GO:0010212,GO:0010332,GO:0010604,GO:0010941,GO:0012501,GO:0012505,GO:0015031,GO:0015833,GO:0016043,GO:0016192,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019692,GO:0019693,GO:0022407,GO:0022409,GO:0023052,GO:0030141,GO:0030155,GO:0031323,GO:0031325,GO:0031341,GO:0031343,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032501,GO:0032623,GO:0032940,GO:0032944,GO:0032946,GO:0033036,GO:0033554,GO:0034356,GO:0034404,GO:0034418,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0034774,GO:0035556,GO:0036094,GO:0036230,GO:0042102,GO:0042119,GO:0042127,GO:0042129,GO:0042221,GO:0042278,GO:0042301,GO:0042451,GO:0042453,GO:0042454,GO:0042455,GO:0042493,GO:0042886,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043094,GO:0043101,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045184,GO:0045321,GO:0045577,GO:0045579,GO:0045580,GO:0045582,GO:0045595,GO:0045597,GO:0045619,GO:0045621,GO:0045739,GO:0045785,GO:0045935,GO:0046039,GO:0046070,GO:0046094,GO:0046102,GO:0046115,GO:0046121,GO:0046122,GO:0046124,GO:0046128,GO:0046129,GO:0046130,GO:0046390,GO:0046415,GO:0046434,GO:0046483,GO:0046495,GO:0046496,GO:0046634,GO:0046635,GO:0046637,GO:0046638,GO:0046700,GO:0046903,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0050663,GO:0050670,GO:0050671,GO:0050776,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050863,GO:0050864,GO:0050865,GO:0050867,GO:0050870,GO:0050871,GO:0050896,GO:0051052,GO:0051054,GO:0051094,GO:0051171,GO:0051173,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0051239,GO:0051240,GO:0051249,GO:0051251,GO:0051716,GO:0055086,GO:0060205,GO:0060255,GO:0060548,GO:0065007,GO:0070013,GO:0070228,GO:0070229,GO:0070232,GO:0070233,GO:0070637,GO:0070638,GO:0070663,GO:0070665,GO:0070970,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072521,GO:0072522,GO:0072523,GO:0072524,GO:0072525,GO:0072526,GO:0080090,GO:0080134,GO:0080135,GO:0090407,GO:0097159,GO:0097190,GO:0097193,GO:0097367,GO:0097708,GO:0099503,GO:0101002,GO:1901068,GO:1901069,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659,GO:1902105,GO:1902107,GO:1903037,GO:1903039,GO:1903706,GO:1903708,GO:1904813,GO:2000026,GO:2000106,GO:2000107,GO:2001020,GO:2001022	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
k59_220371_1	272558.10174253	1.92e-30	120.0	COG0539@1|root,COG0539@2|Bacteria,1TQ9N@1239|Firmicutes,4H9PX@91061|Bacilli,1ZARR@1386|Bacillus	91061|Bacilli	J	Ribosomal protein S1	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_412948_1	305700.B447_04387	8.52e-132	388.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,2KUE1@206389|Rhodocyclales	206389|Rhodocyclales	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_477910_1	404589.Anae109_3945	3.26e-40	149.0	COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,42Z7G@68525|delta/epsilon subdivisions,2WU0D@28221|Deltaproteobacteria,2YU48@29|Myxococcales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_382958_1	85643.Tmz1t_2573	6.41e-83	261.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,2KUMA@206389|Rhodocyclales	206389|Rhodocyclales	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_123090_1	694431.DESACE_08065	2.57e-06	49.3	COG1102@1|root,COG1102@2|Bacteria,1RCTZ@1224|Proteobacteria,42R0B@68525|delta/epsilon subdivisions,2WMVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
k59_580741_1	398767.Glov_3284	5.97e-24	99.8	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42PF7@68525|delta/epsilon subdivisions,2WJB5@28221|Deltaproteobacteria,43TV1@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cellulose biosynthesis protein BcsQ	flhG	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
k59_220377_1	1123376.AUIU01000004_gene1162	3.75e-39	140.0	COG2025@1|root,COG2025@2|Bacteria	2|Bacteria	C	fatty acid beta-oxidation using acyl-CoA dehydrogenase	fixB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	iAF987.Gmet_2066,iAF987.Gmet_2257	ETF,ETF_alpha,Fer4
k59_220377_2	1009370.ALO_04286	1.86e-50	170.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4H21S@909932|Negativicutes	909932|Negativicutes	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_412955_1	864051.BurJ1DRAFT_0792	3.37e-38	146.0	COG3303@1|root,COG3303@2|Bacteria,1R8WP@1224|Proteobacteria,2VZZU@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_744110_1	1525715.IX54_06500	1.25e-17	87.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TR8F@28211|Alphaproteobacteria,2PUA6@265|Paracoccus	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_744110_2	420662.Mpe_A3398	7.28e-05	43.9	2C7YM@1|root,32RK3@2|Bacteria,1N2IQ@1224|Proteobacteria,2VX9I@28216|Betaproteobacteria,1KMEU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_580746_1	436308.Nmar_0863	8.68e-15	73.6	COG1915@1|root,arCOG04422@2157|Archaea,41SBQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
k59_580746_2	436308.Nmar_0862	2.06e-57	180.0	arCOG08655@1|root,arCOG08655@2157|Archaea,41SR9@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_249643_1	582744.Msip34_0519	3e-75	240.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,2KKBE@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_155846_1	519989.ECTPHS_00170	3.02e-126	372.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales	135613|Chromatiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_612686_1	436308.Nmar_1690	2.77e-187	528.0	COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_711701_1	1244869.H261_10432	1.9e-50	172.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTYY@28211|Alphaproteobacteria,2JRF3@204441|Rhodospirillales	204441|Rhodospirillales	S	alcohol dehydrogenase	-	-	-	ko:K18382	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_57193_1	351348.Maqu_0982	1.56e-47	167.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,1T44C@1236|Gammaproteobacteria,46D6Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_873324_1	1038860.AXAP01000015_gene2094	1.18e-102	319.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,3JRH2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	aldehyde-lyase activity	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_580758_1	1007105.PT7_0050	2.44e-29	122.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,3T227@506|Alcaligenaceae	28216|Betaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_412968_1	1487953.JMKF01000011_gene5920	0.000384	44.7	COG2340@1|root,COG2340@2|Bacteria,1G6I4@1117|Cyanobacteria,1HBFT@1150|Oscillatoriales	1117|Cyanobacteria	S	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP
k59_515390_1	1125863.JAFN01000001_gene1391	6.55e-84	276.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1PEPK@1224|Proteobacteria,42NJ8@68525|delta/epsilon subdivisions,2WM57@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0348	Peptidase_M1
k59_744132_1	1071073.KI530539_gene126	4.33e-12	72.8	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,1ZBG8@1386|Bacillus	91061|Bacilli	E	COG0747 ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_772196_1	794903.OPIT5_19280	2.23e-55	177.0	COG0614@1|root,COG0614@2|Bacteria,46XU2@74201|Verrucomicrobia,3K9Q9@414999|Opitutae	414999|Opitutae	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
k59_939915_1	748247.AZKH_2214	5.15e-43	155.0	COG3290@1|root,COG4191@1|root,COG3290@2|Bacteria,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,2WEZZ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_249663_1	977880.RALTA_A2160	6.73e-91	288.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,1K0F8@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_412977_1	710686.Mycsm_05706	6.42e-46	167.0	COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,23FDA@1762|Mycobacteriaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
k59_939919_1	926550.CLDAP_27900	4.46e-42	152.0	COG0438@1|root,COG0438@2|Bacteria,2G60E@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
k59_412980_1	177437.HRM2_16570	3.89e-30	112.0	COG4109@1|root,COG4109@2|Bacteria,1N96M@1224|Proteobacteria,42V82@68525|delta/epsilon subdivisions,2WS7X@28221|Deltaproteobacteria,2MNU8@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
k59_842344_1	936455.KI421499_gene7029	4.07e-47	163.0	COG0683@1|root,COG0683@2|Bacteria,1N3V5@1224|Proteobacteria,2U1KS@28211|Alphaproteobacteria,3JVMY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	MA20_22595	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_279052_1	388413.ALPR1_05870	2.7e-65	206.0	COG3264@1|root,COG3264@2|Bacteria,4PMKM@976|Bacteroidetes	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_279052_2	313598.MED152_09025	1.98e-09	58.2	COG0457@1|root,COG3103@1|root,COG0457@2|Bacteria,COG3103@2|Bacteria,4NF5V@976|Bacteroidetes,1HYKU@117743|Flavobacteriia,3VVPU@52959|Polaribacter	976|Bacteroidetes	T	Bacterial SH3 domain homologues	batE	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2
k59_1003650_1	1121104.AQXH01000002_gene507	1.81e-45	157.0	COG1250@1|root,COG1250@2|Bacteria,4NGU8@976|Bacteroidetes,1IP70@117747|Sphingobacteriia	976|Bacteroidetes	I	3-hydroxyacyl-CoA dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_448536_1	768704.Desmer_4321	1.9e-112	343.0	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia,26246@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_25533_1	1168065.DOK_05290	4.24e-19	84.0	COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,1S4EZ@1236|Gammaproteobacteria,1J6QY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	paaI	GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	iBWG_1329.BWG_1225,iEC55989_1330.EC55989_1532,iECDH10B_1368.ECDH10B_1521,iECDH1ME8569_1439.EcDH1_2249,iECIAI1_1343.ECIAI1_1396,iECO103_1326.ECO103_1533,iECO111_1330.ECO111_1790,iECO26_1355.ECO26_2000,iECSE_1348.ECSE_1481,iEKO11_1354.EKO11_2417,iETEC_1333.ETEC_1471,iEcDH1_1363.EcDH1_2249,iEcE24377_1341.EcE24377A_1581,iEcHS_1320.EcHS_A1483,iEcolC_1368.EcolC_2259,iUMNK88_1353.UMNK88_1803,iY75_1357.Y75_RS07340	4HBT
k59_25533_2	883078.HMPREF9695_01738	1.94e-57	186.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,3JSP8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1011202_1	635013.TherJR_1768	6.91e-28	113.0	COG0805@1|root,COG0805@2|Bacteria,1U7N7@1239|Firmicutes,24KCD@186801|Clostridia,261Q1@186807|Peptococcaceae	186801|Clostridia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_195847_1	1235457.C404_14925	8.24e-14	69.3	COG2963@1|root,COG2963@2|Bacteria,1N7SX@1224|Proteobacteria,2VVQR@28216|Betaproteobacteria,1K8NW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_419918_1	1288494.EBAPG3_28580	1.66e-158	469.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,372M8@32003|Nitrosomonadales	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_391035_1	1121127.JAFA01000070_gene6095	1.99e-37	139.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,2W5BV@28216|Betaproteobacteria,1K5NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_795679_1	357808.RoseRS_2499	3.56e-11	68.6	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2G790@200795|Chloroflexi,375DF@32061|Chloroflexia	32061|Chloroflexia	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,SpoIIE
k59_881077_1	247633.GP2143_17896	1.23e-48	175.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
k59_419947_1	1183438.GKIL_1664	4.02e-41	142.0	COG3415@1|root,COG3415@2|Bacteria,1G802@1117|Cyanobacteria	1117|Cyanobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_32
k59_391066_1	686340.Metal_1493	1.58e-70	229.0	COG2110@1|root,COG2110@2|Bacteria	2|Bacteria	P	phosphatase homologous to the C-terminal domain of histone macroH2A1	CP_0667	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	Macro
k59_324327_1	477184.KYC_01380	3.22e-157	459.0	COG1178@1|root,COG1178@2|Bacteria,1R0MN@1224|Proteobacteria,2VK7P@28216|Betaproteobacteria,3T76X@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_65113_1	999141.GME_06884	7.63e-63	204.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1XHQS@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_912563_1	931277.C448_07127	5.17e-57	187.0	COG3246@1|root,arCOG06125@2157|Archaea,2XUGZ@28890|Euryarchaeota,23SF9@183963|Halobacteria	183963|Halobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
k59_228198_1	330214.NIDE2742	4.02e-19	80.5	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	opuCA	-	2.7.7.7	ko:K02342,ko:K05847,ko:K07182	ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440	M00209,M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400	3.A.1.12	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_228198_2	330214.NIDE2741	1.24e-71	224.0	COG0113@1|root,COG0113@2|Bacteria,3J0DV@40117|Nitrospirae	40117|Nitrospirae	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_484655_1	1163409.UUA_08054	2.8e-38	140.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1X3UD@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the prokaryotic GSH synthase family	gshB	GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_256590_1	485913.Krac_0278	3.9e-50	170.0	COG0604@1|root,COG0604@2|Bacteria,2G84Q@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_1028414_1	247634.GPB2148_3294	1.44e-26	101.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1RXCG@1236|Gammaproteobacteria,1JBB2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_324348_1	640081.Dsui_2483	9.02e-28	107.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,2KVQS@206389|Rhodocyclales	206389|Rhodocyclales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_324348_2	794846.AJQU01000006_gene877	8.43e-28	104.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,4B9TA@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k59_652866_1	1380394.JADL01000014_gene153	4.44e-91	292.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JP8A@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_391110_1	266264.Rmet_5216	1.21e-17	89.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WBWX@28216|Betaproteobacteria,1K6U7@119060|Burkholderiaceae	28216|Betaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_65143_1	697284.ERIC2_c20330	1.23e-11	69.3	COG0489@1|root,COG0489@2|Bacteria,1TS4R@1239|Firmicutes,4HCEN@91061|Bacilli,26TAD@186822|Paenibacillaceae	91061|Bacilli	D	capsular	ywqD	-	2.7.10.2	ko:K00903	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_31,ParA
k59_912585_1	247490.KSU1_B0100	4.74e-101	304.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_456458_2	261292.Nit79A3_1944	1.29e-129	378.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,372E1@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1011282_1	1034943.BN1094_01087	2.25e-55	186.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1JF9E@118969|Legionellales	118969|Legionellales	L	Transposase IS116/IS110/IS902 family	-	GO:0003674,GO:0003824,GO:0004803,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_256614_1	926569.ANT_24720	3.07e-75	244.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G88D@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA_3
k59_881130_1	1286093.C266_15819	6.14e-98	290.0	COG0461@1|root,COG0461@2|Bacteria,1MVP7@1224|Proteobacteria,2VSR8@28216|Betaproteobacteria,1K1C7@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_324377_1	351160.RRC299	5.27e-31	113.0	COG0454@1|root,arCOG00826@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	ko:K03829	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_256625_1	1163617.SCD_n02429	2.49e-56	183.0	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2WFQP@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM Conserved TM helix repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_65177_1	665029.EAMY_3484	2.52e-37	140.0	COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,1RRH3@1236|Gammaproteobacteria,3X5M4@551|Erwinia	1236|Gammaproteobacteria	P	Sn-glycerol-3-phosphate ABC	ugpB	GO:0001407,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0015748,GO:0015794,GO:0030288,GO:0030313,GO:0031975,GO:0034220,GO:0042597,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	iEcE24377_1341.EcE24377A_3931	SBP_bac_8
k59_912616_1	290315.Clim_2069	2.67e-40	152.0	COG2989@1|root,COG2989@2|Bacteria,1FEJK@1090|Chlorobi	1090|Chlorobi	S	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1011312_1	1121104.AQXH01000001_gene1307	2.33e-18	89.7	COG1361@1|root,COG2304@1|root,COG2931@1|root,COG3420@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3420@2|Bacteria,COG4932@2|Bacteria,4NMB8@976|Bacteroidetes,1IQMS@117747|Sphingobacteriia	976|Bacteroidetes	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,HYR,SdrD_B
k59_484713_1	1123279.ATUS01000001_gene2264	2.39e-32	119.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1028454_1	1121098.HMPREF1534_00320	2.66e-41	152.0	COG4231@1|root,COG4231@2|Bacteria,4NJM1@976|Bacteroidetes,2FMYS@200643|Bacteroidia,4AN7N@815|Bacteroidaceae	976|Bacteroidetes	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C
k59_779275_2	153948.NAL212_2615	1.44e-49	172.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,3720Q@32003|Nitrosomonadales	28216|Betaproteobacteria	C	TrkA-N domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_324426_1	1380394.JADL01000012_gene926	1.77e-58	192.0	COG3836@1|root,COG3836@2|Bacteria,1RAYB@1224|Proteobacteria,2U6PQ@28211|Alphaproteobacteria,2JWG7@204441|Rhodospirillales	204441|Rhodospirillales	G	HpcH/HpaI aldolase/citrate lyase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_324426_2	1380394.JADL01000006_gene5324	2.78e-55	191.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_256659_1	438753.AZC_4367	2.44e-20	85.9	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2U5JQ@28211|Alphaproteobacteria,3EZZU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Carboxymuconolactone decarboxylase family	MA20_20490	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_256659_2	391937.NA2_14332	2.07e-74	232.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0235, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_540750_1	1304872.JAGC01000003_gene3559	2.99e-40	151.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WKZE@28221|Deltaproteobacteria,2MGCG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	transporter antisigma-factor antagonist STAS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_420044_1	706587.Desti_5385	7.74e-49	177.0	COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481,ko:K07712,ko:K07713	ko02020,map02020	M00497,M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,PAS_4,Response_reg,Sigma54_activat
k59_1028463_1	1123487.KB892866_gene1651	1.52e-83	263.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,2KVUU@206389|Rhodocyclales	206389|Rhodocyclales	C	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_881188_1	1123368.AUIS01000009_gene2439	4.87e-143	431.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Glyco_hydro_77
k59_456550_2	1121035.AUCH01000012_gene3017	2.46e-18	85.9	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,2KWIW@206389|Rhodocyclales	206389|Rhodocyclales	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
k59_795737_1	323848.Nmul_A0699	5.81e-104	312.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,371MB@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_65245_1	344747.PM8797T_02389	1.25e-70	229.0	COG3385@1|root,COG3385@2|Bacteria,2IYW8@203682|Planctomycetes	203682|Planctomycetes	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_779308_1	640081.Dsui_1968	7.11e-88	264.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,2KU8F@206389|Rhodocyclales	206389|Rhodocyclales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_484776_1	1230343.CANP01000039_gene2942	1.29e-80	255.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1JCJI@118969|Legionellales	118969|Legionellales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009986,GO:0009987,GO:0016465,GO:0018995,GO:0022610,GO:0030430,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0050789,GO:0051082,GO:0051704,GO:0061077,GO:0065007,GO:0101031,GO:1990220,GO:2000535	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_456591_1	1232410.KI421425_gene1545	5.81e-27	102.0	COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,43UYT@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
k59_456591_2	1232410.KI421425_gene1546	2.16e-52	170.0	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria,43TGA@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_391244_2	999419.HMPREF1077_01848	1.49e-49	175.0	COG0178@1|root,COG0178@2|Bacteria,4NEHM@976|Bacteroidetes,2FNFZ@200643|Bacteroidia,22X2V@171551|Porphyromonadaceae	976|Bacteroidetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_21,ABC_tran
k59_653020_1	1121405.dsmv_2727	7.63e-33	128.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MHRD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_653020_2	933262.AXAM01000002_gene557	7.08e-53	171.0	COG0071@1|root,COG0071@2|Bacteria,1RE2H@1224|Proteobacteria,42RP0@68525|delta/epsilon subdivisions,2WNC4@28221|Deltaproteobacteria,2MK0Y@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_1011404_1	265072.Mfla_2443	1.15e-91	283.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,2KKUY@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_484783_3	1540257.JQMW01000004_gene441	6.76e-46	168.0	COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,247TB@186801|Clostridia,36EZ3@31979|Clostridiaceae	186801|Clostridia	L	Protein of unknown function (DUF2800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2800
k59_228411_1	1116472.MGMO_45c00320	7.08e-34	134.0	COG0577@1|root,COG0577@2|Bacteria,1PJZX@1224|Proteobacteria,1RU56@1236|Gammaproteobacteria,1XDTW@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_391279_1	292415.Tbd_2370	4.6e-110	333.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1KRC1@119069|Hydrogenophilales	119069|Hydrogenophilales	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_881258_2	1267005.KB911258_gene362	5.92e-51	171.0	COG5402@1|root,COG5402@2|Bacteria,1N26C@1224|Proteobacteria,2TT9K@28211|Alphaproteobacteria,3N79F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1214)	MA20_15585	-	-	-	-	-	-	-	-	-	-	-	DUF1214
k59_484805_2	1255043.TVNIR_3026	3.82e-73	234.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_779360_1	1121374.KB891575_gene794	8.44e-63	207.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1011454_1	1538644.KO02_23300	3.02e-09	63.2	COG4485@1|root,COG4485@2|Bacteria,4NEE5@976|Bacteroidetes,1IP87@117747|Sphingobacteriia	976|Bacteroidetes	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
k59_256762_1	323097.Nham_3895	1.92e-137	395.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,3JWD8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k59_283436_1	926569.ANT_12050	2.94e-60	193.0	COG3634@1|root,COG3634@2|Bacteria,2G6SQ@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM glutaredoxin-like domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
k59_488373_1	1191523.MROS_1036	8.21e-36	132.0	COG0592@1|root,COG0592@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_922204_1	257313.BP2116	5.17e-31	121.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,3T21B@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_398151_1	945713.IALB_3182	6.27e-47	172.0	COG0745@1|root,COG3291@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3291@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HTH_18,HisKA,PAS_4,PKD,Reg_prop,Response_reg,Y_Y_Y
k59_693724_1	266264.Rmet_4835	5.47e-87	282.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VJKJ@28216|Betaproteobacteria,1K04G@119060|Burkholderiaceae	28216|Betaproteobacteria	M	penicillin-binding protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_334230_1	1056512.D515_01202	3.77e-30	123.0	COG3385@1|root,COG3385@2|Bacteria,1R55Y@1224|Proteobacteria,1RRSD@1236|Gammaproteobacteria,1XVIP@135623|Vibrionales	135623|Vibrionales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_431861_1	323261.Noc_0962	3.38e-99	298.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WZ4R@135613|Chromatiales	135613|Chromatiales	BQ	PFAM histone deacetylase superfamily	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_986819_1	279714.FuraDRAFT_3506	9.75e-63	198.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2VIMK@28216|Betaproteobacteria,2KRTA@206351|Neisseriales	206351|Neisseriales	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
k59_301107_1	159087.Daro_1631	1.76e-28	115.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,2KUB6@206389|Rhodocyclales	206389|Rhodocyclales	ET	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_301107_2	883168.HMPREF9318_00836	1.69e-25	103.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli	91061|Bacilli	KT	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_234907_1	631454.N177_1017	4.64e-47	160.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TRA8@28211|Alphaproteobacteria,1JN92@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_138527_1	324925.Ppha_0758	1.82e-68	214.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_595539_1	1121098.HMPREF1534_02341	7.59e-06	47.8	COG2738@1|root,COG2738@2|Bacteria,4NDWG@976|Bacteroidetes,2FPBQ@200643|Bacteroidia,4AKB8@815|Bacteroidaceae	976|Bacteroidetes	S	neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
k59_8023_1	864051.BurJ1DRAFT_4384	6.39e-96	296.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1KJB3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	pilB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_888650_2	1189612.A33Q_2376	1.27e-19	92.4	COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SnoaL_3
k59_334249_1	640081.Dsui_3081	4.52e-96	298.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KVAY@206389|Rhodocyclales	206389|Rhodocyclales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_856363_1	717785.HYPMC_3809	2.12e-46	163.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2TTQ4@28211|Alphaproteobacteria,3N73Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Histidyl-tRNA synthetase	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_757115_1	1096769.Pelub83DRAFT_0317	3.5e-72	234.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2TSN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase fumarate reductase, flavoprotein subunit	MA20_14860	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_40451_1	744872.Spica_2598	2.33e-06	55.8	COG4206@1|root,COG4206@2|Bacteria,2JBKG@203691|Spirochaetes	203691|Spirochaetes	H	Outer membrane protein beta-barrel family	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_366621_1	1125971.ASJB01000030_gene1103	1.74e-27	103.0	COG0346@1|root,COG0346@2|Bacteria,2IKRF@201174|Actinobacteria,4E4DZ@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_366621_2	935866.JAER01000012_gene3546	7.02e-26	98.2	COG5649@1|root,COG5649@2|Bacteria,2IHVG@201174|Actinobacteria,4DR41@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_954713_1	298655.KI912266_gene4779	3.08e-53	182.0	COG4638@1|root,COG4638@2|Bacteria,2GM3P@201174|Actinobacteria,4EVJD@85013|Frankiales	201174|Actinobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
k59_73425_1	1249627.D779_3882	1.33e-108	333.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales	135613|Chromatiales	U	sulphate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_138540_2	1347393.HG726020_gene1651	3.64e-23	97.8	COG0667@1|root,COG0667@2|Bacteria,4NFCN@976|Bacteroidetes,2FMAG@200643|Bacteroidia,4AKEC@815|Bacteroidaceae	976|Bacteroidetes	C	Oxidoreductase, aldo keto reductase family protein	gpr	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_888659_1	690850.Desaf_0199	1.35e-88	277.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2M915@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_563102_1	1123070.KB899259_gene1957	2.11e-53	179.0	COG0545@1|root,COG0545@2|Bacteria,46U5S@74201|Verrucomicrobia,2IVK3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
k59_366630_2	1121015.N789_00865	6.62e-59	202.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	HJ	GNAT family acetyltransferase	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	ATP-grasp_5,CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK
k59_661116_1	237368.SCABRO_01997	9.77e-60	201.0	COG1007@1|root,COG1007@2|Bacteria,2IXC6@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_954722_1	331869.BAL199_06164	2.73e-88	276.0	COG0477@1|root,COG2814@2|Bacteria,1MUDA@1224|Proteobacteria,2TS0P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_726253_1	926550.CLDAP_01400	3.11e-31	113.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	ATC_hydrolase,SWIM
k59_1015596_1	864051.BurJ1DRAFT_3978	2.59e-81	255.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KK5X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_888668_1	1288494.EBAPG3_13740	4.83e-55	180.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,371Q5@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	fabG	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_497896_1	305700.B447_12157	5.43e-76	236.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,2KUWU@206389|Rhodocyclales	206389|Rhodocyclales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_73443_1	1458427.BAWN01000017_gene1125	1.32e-30	124.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,4AAXQ@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_334289_1	335659.S23_62180	2.74e-83	256.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TTXX@28211|Alphaproteobacteria,3JRKX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	gltI	-	-	ko:K02030,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_138566_1	1147.D082_14880	1.4e-23	101.0	COG0277@1|root,COG0277@2|Bacteria,1G1U2@1117|Cyanobacteria,1H53T@1142|Synechocystis	1117|Cyanobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_138566_2	266117.Rxyl_2832	2.86e-20	92.4	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4CRXQ@84995|Rubrobacteria	84995|Rubrobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_824375_1	945713.IALB_0586	1.31e-63	219.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2
k59_138569_2	1198232.CYCME_1419	1.61e-08	59.7	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,1RNJD@1236|Gammaproteobacteria,46189@72273|Thiotrichales	72273|Thiotrichales	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_171160_2	497321.C664_08623	1.58e-59	192.0	COG0437@1|root,COG0437@2|Bacteria,1N9WY@1224|Proteobacteria,2VKT4@28216|Betaproteobacteria,2KUVH@206389|Rhodocyclales	206389|Rhodocyclales	C	MauM NapG family ferredoxin-type protein	napG	-	-	ko:K02573	-	-	-	-	ko00000	-	-	-	Fer4_4,Fer4_7
k59_563126_1	395495.Lcho_0484	2.44e-51	182.0	COG2227@1|root,COG2520@1|root,COG2227@2|Bacteria,COG2520@2|Bacteria	2|Bacteria	J	tRNA (guanine(37)-N(1))-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11,Methyltransf_21,Methyltransf_23,Methyltransf_25
k59_497913_1	713586.KB900536_gene245	1.25e-39	137.0	COG0599@1|root,COG2146@1|root,COG0599@2|Bacteria,COG2146@2|Bacteria,1RCCG@1224|Proteobacteria	1224|Proteobacteria	P	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Rieske
k59_563127_1	768671.ThimaDRAFT_4355	6.39e-62	210.0	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,1SKFJ@1236|Gammaproteobacteria,1X099@135613|Chromatiales	135613|Chromatiales	L	COG0841 Cation multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_628073_1	926569.ANT_26670	4.9e-141	414.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi	200795|Chloroflexi	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_922288_1	1366050.N234_01095	3.56e-49	170.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2VJYY@28216|Betaproteobacteria	28216|Betaproteobacteria	G	ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
k59_922288_2	2074.JNYD01000004_gene4949	9.03e-59	192.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4E1T7@85010|Pseudonocardiales	201174|Actinobacteria	E	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
k59_661145_1	1121033.AUCF01000029_gene293	2.74e-54	182.0	2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2TTH2@28211|Alphaproteobacteria,2JR3R@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_171162_1	96561.Dole_1171	3.42e-105	337.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MIS3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_431926_1	1288494.EBAPG3_7550	1.73e-94	300.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_922293_1	1288494.EBAPG3_18220	1.27e-98	301.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,372FT@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
k59_824388_1	298655.KI912267_gene7902	0.000165	49.7	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4ETGG@85013|Frankiales	201174|Actinobacteria	K	transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C
k59_269079_2	1128427.KB904821_gene361	6.77e-46	169.0	COG2114@1|root,COG2202@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769,ko:K11959	ko00230,ko02010,ko02025,ko04113,ko04213,map00230,map02010,map02025,map04113,map04213	M00323,M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Guanylate_cyc,PAS_4,PAS_9,Peripla_BP_5
k59_954765_1	990285.RGCCGE502_20515	2.39e-20	89.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TUQB@28211|Alphaproteobacteria,4BA11@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component	-	GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039	-	ko:K01995,ko:K11957	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	ABC_tran,BCA_ABC_TP_C
k59_954765_2	1231391.AMZF01000008_gene1609	1.62e-37	135.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,3T3A2@506|Alcaligenaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2,DUF3382
k59_138594_1	1207063.P24_03830	1.79e-66	226.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JP8A@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_856419_1	1123054.KB907706_gene2369	4.25e-51	178.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1X0AF@135613|Chromatiales	135613|Chromatiales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_563145_1	639283.Snov_0188	3.11e-55	185.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,3EYRF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_563145_2	1125973.JNLC01000010_gene1417	3.78e-108	331.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,3JZ96@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_497943_1	1123504.JQKD01000002_gene3682	6.29e-111	328.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VH77@28216|Betaproteobacteria,4AAT7@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FMN-dependent alpha-hydroxy acid dehydrogenase	lldD	-	1.1.2.3,1.1.3.15	ko:K00101,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00196,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_888701_1	384676.PSEEN0248	3.02e-07	55.1	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	dctD	-	-	ko:K10126	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_888701_2	933262.AXAM01000005_gene2487	1.34e-14	73.2	COG1639@1|root,COG1639@2|Bacteria,1RKNA@1224|Proteobacteria,42TE8@68525|delta/epsilon subdivisions,2WPCE@28221|Deltaproteobacteria,2MPXW@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k59_954770_1	1034347.CAHJ01000072_gene2723	3.34e-41	144.0	COG2197@1|root,COG2197@2|Bacteria,1TSBV@1239|Firmicutes,4HC74@91061|Bacilli,1ZC5P@1386|Bacillus	91061|Bacilli	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	nreC	-	-	ko:K07696	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_8101_1	688269.Theth_0801	6.52e-20	90.5	COG0154@1|root,COG0154@2|Bacteria,2GBX2@200918|Thermotogae	200918|Thermotogae	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_8101_2	1151122.AQYD01000007_gene24	2.29e-22	96.7	COG2227@1|root,COG2227@2|Bacteria,2IIE2@201174|Actinobacteria,4FS38@85023|Microbacteriaceae	201174|Actinobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.11	ko:K03428	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
k59_40515_1	945713.IALB_0595	3.48e-13	63.9	COG0238@1|root,COG0238@2|Bacteria	2|Bacteria	J	rRNA binding	rpsR	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_40515_2	945713.IALB_0594	6.07e-85	253.0	COG0629@1|root,COG0629@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_40515_3	945713.IALB_0593	1.77e-24	97.1	COG0360@1|root,COG0360@2|Bacteria	2|Bacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
k59_825372_2	795666.MW7_1233	9.31e-14	70.1	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2VN4W@28216|Betaproteobacteria,1K58I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	DMSO reductase	dmsC	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
k59_399066_1	1042326.AZNV01000012_gene1947	3.77e-178	502.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,4BCDD@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
k59_74425_1	1123319.AUBE01000023_gene5814	1.35e-14	79.0	COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_987825_1	1485544.JQKP01000005_gene289	1.19e-08	55.1	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,44W1Q@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
k59_335231_1	583345.Mmol_0241	4.32e-08	59.3	COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VMD2@28216|Betaproteobacteria,2KKBN@206350|Nitrosomonadales	206350|Nitrosomonadales	U	PFAM Sporulation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,SPOR
k59_1016097_1	1158292.JPOE01000002_gene2250	6.67e-52	173.0	COG0500@1|root,COG2226@2|Bacteria,1NRR4@1224|Proteobacteria,2W05F@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_335235_1	1121106.JQKB01000034_gene5956	5.9e-18	87.4	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,2JSNM@204441|Rhodospirillales	204441|Rhodospirillales	S	Phenazine biosynthesis-like protein	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
k59_662152_1	1123393.KB891316_gene1510	4.93e-65	210.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,1KSI6@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_172120_1	511062.GU3_00725	1.57e-12	64.7	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1Y4SJ@135624|Aeromonadales	135624|Aeromonadales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
k59_139563_1	1163617.SCD_n00796	1.07e-66	218.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	peptidase m48, ste24p	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_74450_2	312153.Pnuc_0466	2.58e-53	178.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2VHG7@28216|Betaproteobacteria,1K2W7@119060|Burkholderiaceae	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_335244_1	266265.Bxe_C1130	8.63e-52	179.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,1K1TG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_274932_1	1229909.NSED_01160	2.81e-38	133.0	COG1056@1|root,arCOG00972@2157|Archaea,41SHQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Nicotinamide-nucleotide adenylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_405878_1	247634.GPB2148_3660	9.72e-76	233.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1J5FZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_931650_1	215803.DB30_4995	6.25e-177	533.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA1	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
k59_440732_2	861208.AGROH133_04621	6.56e-17	79.0	COG0656@1|root,COG0656@2|Bacteria,1MWFS@1224|Proteobacteria,2TT2Q@28211|Alphaproteobacteria,4BBW3@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Aldo keto reductases, related to diketogulonate reductase	dkgB	-	1.1.1.346	ko:K06222	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_274935_2	555779.Dthio_PD2281	1.4e-43	158.0	COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WPR9@28221|Deltaproteobacteria,2M7TV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k59_115065_1	460265.Mnod_2285	3.38e-156	465.0	28JZZ@1|root,2Z9PZ@2|Bacteria,1N3C6@1224|Proteobacteria,2TSCX@28211|Alphaproteobacteria,1JTZB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_995825_1	1077972.ARGLB_113_00410	5.22e-26	110.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,1W8B3@1268|Micrococcaceae	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,VCBS
k59_670546_1	382245.ASA_3129	1.88e-25	108.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1Y3V8@135624|Aeromonadales	135624|Aeromonadales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_343385_1	1415778.JQMM01000001_gene137	2.79e-59	189.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1J84B@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Proteasome subunit	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
k59_343385_2	1168065.DOK_08339	1.58e-17	80.9	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria,1J6Y9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_670550_1	640081.Dsui_1105	1.4e-130	400.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,2KVJX@206389|Rhodocyclales	206389|Rhodocyclales	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_212604_1	1123256.KB907939_gene284	5.67e-13	64.7	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1X6CE@135614|Xanthomonadales	135614|Xanthomonadales	J	endoribonuclease	yjgF	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_212604_2	1123504.JQKD01000004_gene5020	1.92e-71	228.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VK7F@28216|Betaproteobacteria,4AJ1Q@80864|Comamonadaceae	28216|Betaproteobacteria	C	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_440752_1	1454004.AW11_01012	6.35e-75	233.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator crp fnr family	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_572435_1	1128111.HMPREF0870_01675	9.82e-11	60.8	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,4H4HZ@909932|Negativicutes	909932|Negativicutes	H	cob(I)yrinic acid a,c-diamide adenosyltransferase	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
k59_532607_1	509190.Cseg_3750	0.000109	48.5	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2TRQ3@28211|Alphaproteobacteria,2KGC1@204458|Caulobacterales	204458|Caulobacterales	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
k59_375496_1	452637.Oter_0894	2.61e-119	377.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae	414999|Opitutae	E	glutamate synthase	-	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_604700_1	522306.CAP2UW1_1752	4.57e-60	193.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_931681_1	795666.MW7_1513	2.16e-52	180.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VHHD@28216|Betaproteobacteria,1K6CI@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	DctM
k59_931681_2	869210.Marky_0296	2.38e-74	235.0	COG4663@1|root,COG4663@2|Bacteria,1WJ6R@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
k59_735806_2	926569.ANT_01570	1.73e-116	350.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_471042_1	1266925.JHVX01000004_gene1257	2.26e-86	261.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,371WB@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Glutathione S-transferase, N-terminal domain	gstI	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_2
k59_309612_1	402881.Plav_2848	9.66e-25	98.6	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,1JPKX@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	MA20_22025	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_309612_2	266264.Rmet_0179	4.31e-11	66.2	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1K1SK@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_931692_1	1122927.KB895416_gene3423	3.7e-60	196.0	COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,4H9TV@91061|Bacilli,26RBP@186822|Paenibacillaceae	91061|Bacilli	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_637125_1	936455.KI421499_gene690	1.13e-85	257.0	COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,2TSPZ@28211|Alphaproteobacteria,3JRYQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GK	Transcriptional regulator sugar kinase	-	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_637125_2	1128111.HMPREF0870_00304	1.92e-14	71.2	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H407@909932|Negativicutes	909932|Negativicutes	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_147828_1	95619.PM1_0224375	1.11e-16	82.4	COG0664@1|root,COG0664@2|Bacteria,1N94I@1224|Proteobacteria,1SC9S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_440774_1	1163617.SCD_n02240	4.55e-92	277.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VQEJ@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
k59_440774_2	472759.Nhal_1714	1.4e-29	110.0	COG2128@1|root,COG2128@2|Bacteria,1RC52@1224|Proteobacteria,1S2A0@1236|Gammaproteobacteria,1X15W@135613|Chromatiales	135613|Chromatiales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_931697_1	292415.Tbd_1124	1.33e-29	118.0	COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,2VRC6@28216|Betaproteobacteria,1KRTV@119069|Hydrogenophilales	119069|Hydrogenophilales	J	SmpA / OmlA family	-	-	-	ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	SmpA_OmlA
k59_604730_1	1242864.D187_005763	2.76e-86	271.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1020329_1	62928.azo0472	1.47e-88	273.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,2KV3P@206389|Rhodocyclales	206389|Rhodocyclales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_833960_1	1485544.JQKP01000002_gene1376	2.5e-107	347.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,44V4V@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	Neisseria PilC beta-propeller domain	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_274960_2	762983.HMPREF9444_01402	1.77e-33	122.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,1Y4HI@135624|Aeromonadales	135624|Aeromonadales	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_212638_1	1121861.KB899935_gene468	7.97e-93	281.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,2JQ3B@204441|Rhodospirillales	204441|Rhodospirillales	ET	general L-amino acid-binding periplasmic protein AapJ	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k59_212638_2	1234364.AMSF01000017_gene1473	1.47e-27	104.0	COG1993@1|root,COG1993@2|Bacteria,1RH30@1224|Proteobacteria,1SFPH@1236|Gammaproteobacteria,1X85A@135614|Xanthomonadales	135614|Xanthomonadales	S	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	DUF190
k59_405933_1	1121405.dsmv_2844	2.56e-115	342.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria,2MJN6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
k59_147842_1	179408.Osc7112_0508	5e-83	278.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3322@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3322@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H82F@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF,GAF_3,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_405936_1	1411123.JQNH01000001_gene2121	1.28e-163	478.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TQYI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	CoA binding domain	MA20_15065	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_309632_1	392499.Swit_3144	4.53e-69	238.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_17470_1	177437.HRM2_16900	3.82e-53	184.0	COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,42MPF@68525|delta/epsilon subdivisions,2X5BJ@28221|Deltaproteobacteria,2MISB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fer4,Fer4_20,Fer4_9,Pyr_redox_2
k59_17470_2	1410622.JNKY01000019_gene1762	9.98e-22	95.5	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,27KNR@186928|unclassified Lachnospiraceae	186801|Clostridia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	hymB	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_670612_1	365044.Pnap_1319	4.42e-11	68.2	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N6EM@1224|Proteobacteria,2WEXT@28216|Betaproteobacteria,4ADTI@80864|Comamonadaceae	28216|Betaproteobacteria	JM	OmpA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,SmpA_OmlA
k59_309634_1	926550.CLDAP_08540	4.99e-09	57.0	COG3845@1|root,COG3845@2|Bacteria,2G625@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_309634_2	926569.ANT_14800	2.32e-32	121.0	COG1319@1|root,COG1319@2|Bacteria,2G8QC@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_17474_1	1547437.LL06_14125	2.01e-60	207.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,43IQI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_637155_1	926562.Oweho_1053	1.12e-98	306.0	COG1164@1|root,COG1164@2|Bacteria,4NJFW@976|Bacteroidetes,1I88A@117743|Flavobacteriia	976|Bacteroidetes	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
k59_735860_1	444875.E3SMF7_9CAUD	6.24e-11	68.9	4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses  no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae	10744|Podoviridae	S	outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_995905_1	1485544.JQKP01000002_gene1376	2.05e-169	519.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,44V4V@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	Neisseria PilC beta-propeller domain	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_604768_1	1121405.dsmv_1091	1.05e-53	188.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2MJNU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
k59_638188_1	522306.CAP2UW1_3419	2.6e-108	334.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2VM8J@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
k59_1020837_2	1288494.EBAPG3_14260	1.89e-48	162.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,371PT@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_932830_2	247490.KSU1_D0031	9.37e-49	159.0	COG1145@1|root,COG1145@2|Bacteria,2J2T6@203682|Planctomycetes	203682|Planctomycetes	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_605857_2	933262.AXAM01000001_gene419	1.2e-105	316.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MHXJ@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	pilT1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_638190_1	1121943.KB899991_gene2417	1.67e-75	231.0	COG4122@1|root,COG4122@2|Bacteria,1N57D@1224|Proteobacteria,1S6JT@1236|Gammaproteobacteria,1XK1C@135619|Oceanospirillales	135619|Oceanospirillales	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
k59_116255_1	365044.Pnap_4087	1.39e-23	108.0	COG3391@1|root,COG3391@2|Bacteria,1NQKS@1224|Proteobacteria	1224|Proteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_18585_1	243233.MCA1658	8.26e-62	202.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1XEHV@135618|Methylococcales	135618|Methylococcales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_965463_1	1123367.C666_03060	1.69e-70	224.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2VK3K@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_573632_1	1051985.l11_16470	3.3e-53	184.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,2KPRW@206351|Neisseriales	206351|Neisseriales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_898371_1	1121447.JONL01000022_gene3720	7.69e-17	77.4	2EPJ6@1|root,33H5U@2|Bacteria	2|Bacteria	S	Unextendable partial coding region	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_898371_2	1121422.AUMW01000065_gene1310	4.79e-23	91.3	arCOG05874@1|root,2ZJ01@2|Bacteria,1V450@1239|Firmicutes,24NM6@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_573635_1	96561.Dole_0660	1.41e-46	163.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_835121_1	1121930.AQXG01000002_gene1932	3.25e-80	259.0	COG2217@1|root,COG2217@2|Bacteria,4NERS@976|Bacteroidetes,1IP48@117747|Sphingobacteriia	976|Bacteroidetes	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_508343_1	1304275.C41B8_10920	1.74e-71	239.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_181459_1	987059.RBXJA2T_02862	3.76e-70	217.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2VSP2@28216|Betaproteobacteria,1KM28@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
k59_605887_1	768066.HELO_3976	1.31e-56	199.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XHKJ@135619|Oceanospirillales	135619|Oceanospirillales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_835133_1	296591.Bpro_1911	3.73e-58	193.0	COG3181@1|root,COG3181@2|Bacteria,1R80C@1224|Proteobacteria,2VMJY@28216|Betaproteobacteria,4ACBP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_835133_2	420324.KI912045_gene4445	1.73e-77	247.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_23605	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_835133_3	1071679.BG57_10545	4.06e-25	103.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria,1K5KG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B	ligB	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
k59_965490_1	706587.Desti_4548	3.37e-91	281.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_243641_1	96561.Dole_1677	2.68e-62	215.0	COG0764@1|root,COG3321@1|root,COG0764@2|Bacteria,COG3321@2|Bacteria,1QUWM@1224|Proteobacteria,43BRB@68525|delta/epsilon subdivisions,2WJJ6@28221|Deltaproteobacteria,2MI1Q@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Acyltransferase,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt
k59_638230_1	261292.Nit79A3_0469	1.8e-12	68.9	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,3728D@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_638230_2	1131553.JIBI01000071_gene2157	6.43e-41	148.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,3728D@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_275515_1	1382358.JHVN01000004_gene2603	1.25e-45	159.0	COG1960@1|root,COG1960@2|Bacteria,1TSN3@1239|Firmicutes,4HB0T@91061|Bacilli,21WK8@150247|Anoxybacillus	91061|Bacilli	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_50760_1	987059.RBXJA2T_03798	6.28e-88	268.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,1KJ8A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_573668_1	926569.ANT_17260	2.01e-25	104.0	COG0161@1|root,COG0161@2|Bacteria	2|Bacteria	H	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
k59_573668_2	861450.HMPREF0080_01654	1.08e-13	67.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,4H57T@909932|Negativicutes	909932|Negativicutes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
k59_704627_2	330214.NIDE4330	1.03e-11	64.7	COG3762@1|root,COG3762@2|Bacteria	2|Bacteria	S	Membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
k59_866614_1	436308.Nmar_0105	1.07e-82	251.0	COG0037@1|root,arCOG00042@2157|Archaea,41S84@651137|Thaumarchaeota	651137|Thaumarchaeota	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
k59_310699_1	420662.Mpe_A1346	3.29e-101	306.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,1KJYN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_352125_1	643867.Ftrac_0983	1.86e-38	140.0	COG3958@1|root,COG3958@2|Bacteria,4NEI8@976|Bacteroidetes,47JQN@768503|Cytophagia	976|Bacteroidetes	G	PFAM Transketolase, C-terminal domain	dxs	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_744901_1	1381123.AYOD01000005_gene1210	7.57e-59	185.0	COG2128@1|root,COG2128@2|Bacteria,1RD2I@1224|Proteobacteria,2U7MW@28211|Alphaproteobacteria,43KM1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_250327_1	1095769.CAHF01000005_gene1630	2.19e-93	290.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,473DD@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_250327_2	1123072.AUDH01000002_gene2565	4.3e-30	118.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JSUV@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_973364_1	933262.AXAM01000043_gene1194	2.87e-19	86.7	COG0517@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0618@2|Bacteria,1QW11@1224|Proteobacteria,42Q56@68525|delta/epsilon subdivisions,2WJXU@28221|Deltaproteobacteria,2MI8T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DHH,DHHA1
k59_973364_2	1121405.dsmv_0992	3.96e-48	160.0	COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,42RTX@68525|delta/epsilon subdivisions,2WPGC@28221|Deltaproteobacteria,2MJZX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ACT domain	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
k59_156599_1	1123393.KB891333_gene2506	1.1e-25	96.7	2ESIQ@1|root,33K3E@2|Bacteria,1NJ20@1224|Proteobacteria,2WCCZ@28216|Betaproteobacteria,1KTFU@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_156599_2	292415.Tbd_1502	7.39e-50	169.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,1KRDF@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_613458_1	83406.HDN1F_15960	7.04e-46	169.0	COG3209@1|root,COG3291@1|root,COG4886@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4886@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1J6H5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	silverDB	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,RHS,RHS_repeat
k59_352135_1	420662.Mpe_A1210	3.58e-69	213.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,1KKN4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Periplasmic protein thiol	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
k59_352135_2	864051.BurJ1DRAFT_4181	3.86e-38	132.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,1KM3E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
k59_940707_1	331869.BAL199_27980	4.57e-76	238.0	COG0346@1|root,COG0346@2|Bacteria,1MX75@1224|Proteobacteria,2TRQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_772893_1	1229909.NSED_08235	1.47e-115	332.0	COG0526@1|root,arCOG00314@2157|Archaea,41SKE@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_772893_2	1229909.NSED_08230	4.59e-16	78.6	arCOG08642@1|root,arCOG08642@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_843113_1	292415.Tbd_0873	3.54e-06	47.0	COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,2W1W6@28216|Betaproteobacteria,1KSRH@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Adenosine-5'-phosphosulfate reductase beta subunit	-	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4_9
k59_843113_2	1123392.AQWL01000009_gene1117	8.58e-88	276.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria,1KS3F@119069|Hydrogenophilales	119069|Hydrogenophilales	C	FAD binding domain	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_250338_1	1038869.AXAN01000062_gene2297	2.29e-120	364.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VITF@28216|Betaproteobacteria,1K3N4@119060|Burkholderiaceae	28216|Betaproteobacteria	EQ	Hydantoinase B/oxoprolinase	acxB	-	6.4.1.6	ko:K10854	-	-	-	-	ko00000,ko01000	-	-	-	Hydantoinase_B
k59_712492_1	671143.DAMO_1375	3.21e-69	212.0	COG1259@1|root,COG1259@2|Bacteria,2NP7X@2323|unclassified Bacteria	2|Bacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03617,ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
k59_712492_2	1163730.FFONT_0979	2.23e-48	160.0	COG0537@1|root,arCOG00419@2157|Archaea,2XQK8@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
k59_123876_1	365046.Rta_28820	2.41e-12	65.9	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VJ9Y@28216|Betaproteobacteria,4AC5K@80864|Comamonadaceae	28216|Betaproteobacteria	K	LuxR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_123876_2	1286093.C266_19860	4.37e-55	182.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ9H@28216|Betaproteobacteria,1K0W8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1004411_1	1114964.L485_17130	3.1e-62	206.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_449256_1	375286.mma_1291	1.32e-51	174.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VJTU@28216|Betaproteobacteria,477DI@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_57957_1	296591.Bpro_3022	9.13e-31	117.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VMVX@28216|Betaproteobacteria,4A9VB@80864|Comamonadaceae	28216|Betaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_57957_2	1205680.CAKO01000029_gene5125	1.76e-15	77.8	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_1024693_1	1172186.KB911482_gene4144	2.83e-56	189.0	COG5285@1|root,COG5285@2|Bacteria,2IC8K@201174|Actinobacteria,2373M@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
k59_352154_1	395493.BegalDRAFT_0086	8.65e-89	293.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,460BV@72273|Thiotrichales	72273|Thiotrichales	E	Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_940726_1	1163617.SCD_n00808	1.03e-78	258.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_478606_1	323850.Shew_1876	1.09e-93	293.0	COG1082@1|root,COG1082@2|Bacteria,1NNTS@1224|Proteobacteria,1RP3I@1236|Gammaproteobacteria,2QAKD@267890|Shewanellaceae	1236|Gammaproteobacteria	G	Glycosyl-hydrolase 97 C-terminal, oligomerisation	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
k59_645841_1	717605.Theco_0956	1.53e-34	130.0	COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,4HARP@91061|Bacilli,26SCK@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	GO:0005975,GO:0005996,GO:0006012,GO:0008150,GO:0008152,GO:0019318,GO:0044238,GO:0044281,GO:0071704	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
k59_188637_1	479434.Sthe_0190	3.42e-122	362.0	COG0665@1|root,COG0665@2|Bacteria,2G80C@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00301	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
k59_221165_1	1472716.KBK24_0108755	9.95e-28	113.0	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2VKHW@28216|Betaproteobacteria,1K0FC@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_91895_1	1123368.AUIS01000009_gene2449	9.98e-47	163.0	COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,1RPGR@1236|Gammaproteobacteria,2NCP1@225057|Acidithiobacillales	225057|Acidithiobacillales	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
k59_792967_1	323848.Nmul_A0552	1.31e-126	377.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,37222@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_843145_1	1469245.JFBG01000066_gene134	0.000142	44.7	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_279485_1	1163617.SCD_n02434	7.08e-155	484.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_516222_1	234267.Acid_7641	8.98e-59	194.0	COG4974@1|root,COG4974@2|Bacteria,3Y6KW@57723|Acidobacteria	57723|Acidobacteria	L	phage integrase domain protein SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_352998_1	481448.Minf_1922	5.95e-30	117.0	COG2242@1|root,COG2242@2|Bacteria,46X40@74201|Verrucomicrobia,37H8U@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Met-10+ like-protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_906520_1	247490.KSU1_D1000	1.13e-21	105.0	COG0642@1|root,COG4191@1|root,COG5000@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,2IZWU@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_646645_1	864051.BurJ1DRAFT_3336	6.9e-138	399.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,2VPWJ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	sulfite reductase, dissimilatory-type alpha subunit	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_27115_1	305700.B447_16532	1.85e-75	234.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,2VK0H@28216|Betaproteobacteria,2KW12@206389|Rhodocyclales	206389|Rhodocyclales	S	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_537392_1	414684.RC1_3244	3.83e-27	112.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPRP@204441|Rhodospirillales	204441|Rhodospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_713366_1	1122197.ATWI01000011_gene208	6.51e-05	47.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	4.2.2.3	ko:K01729,ko:K20276	ko00051,ko02024,map00051,map02024	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Big_3_2,CBM_35,CBM_6,He_PIG,VPEP
k59_414325_1	1245471.PCA10_50090	1.91e-57	194.0	2E2YT@1|root,32XZH@2|Bacteria,1MYTS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_157428_1	519989.ECTPHS_11727	1.18e-64	218.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1WW2Y@135613|Chromatiales	135613|Chromatiales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_450114_1	426114.THI_1641	5.51e-79	246.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1KJB6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Belongs to the thiolase family	phbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_92783_1	387093.SUN_1413	1.08e-135	398.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	PFAM sulfatase	atsA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_974321_1	158500.BV97_05755	6.21e-82	258.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_27129_1	864051.BurJ1DRAFT_3327	2e-15	75.5	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,1KKEG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NADPH-dependent glutamate synthase beta	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_21,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_27129_2	713587.THITH_12015	7.2e-172	492.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_844022_1	1266925.JHVX01000013_gene1619	1.26e-68	226.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,37242@32003|Nitrosomonadales	28216|Betaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_974329_1	243231.GSU0222	4.2e-79	244.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions,2WM4F@28221|Deltaproteobacteria,43T32@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.10.3.10,1.9.3.1	ko:K02275,ko:K02297	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3
k59_27135_1	1380394.JADL01000004_gene5821	1.94e-73	248.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,2JPDT@204441|Rhodospirillales	204441|Rhodospirillales	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_537406_1	1038859.AXAU01000001_gene3650	1.41e-57	183.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2UBPX@28211|Alphaproteobacteria,3K2R5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_537406_2	1096769.Pelub83DRAFT_0294	2.12e-07	52.8	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BRA7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	TIGRFAM TRAP transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_479252_1	1122603.ATVI01000005_gene3042	6.99e-63	202.0	COG0668@1|root,COG0668@2|Bacteria,1N4UN@1224|Proteobacteria,1T9TX@1236|Gammaproteobacteria,1XBUR@135614|Xanthomonadales	135614|Xanthomonadales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_251038_1	395019.Bmul_0770	5.32e-10	60.1	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,1K0EF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Isocitrate dehydrogenase	icd	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_251038_2	305700.B447_05088	1.06e-59	192.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,2KVHM@206389|Rhodocyclales	206389|Rhodocyclales	G	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_1025152_1	93220.LV28_09790	7.07e-68	218.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,1K0VW@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	2.7.8.7,3.2.1.52	ko:K00997,ko:K01207	ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501	M00628	R00022,R01625,R05963,R07809,R07810,R10831	RC00002,RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
k59_27147_1	1131266.ARWQ01000081_gene704	5.29e-15	76.3	COG3119@1|root,arCOG02785@2157|Archaea	2157|Archaea	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1005272_1	365046.Rta_10110	3.21e-38	142.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,4AC69@80864|Comamonadaceae	28216|Betaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_1005272_2	267608.RSc0244	2.98e-44	152.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VGZU@28216|Betaproteobacteria,1K0VY@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Dehydrogenase	paaH1	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_941643_2	640081.Dsui_1592	1.51e-18	85.1	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VKV7@28216|Betaproteobacteria,2KV4R@206389|Rhodocyclales	206389|Rhodocyclales	CH	UbiH UbiF VisC COQ6 family	ubiH	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_221993_1	869210.Marky_1642	6.52e-78	246.0	COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_92821_1	1265505.ATUG01000002_gene1543	1.13e-68	227.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2MHS3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_537416_1	709986.Deima_2378	6.58e-53	177.0	COG1023@1|root,COG1023@2|Bacteria,1WIJ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	NAD binding domain of 6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_646694_1	1288494.EBAPG3_7950	2.17e-99	311.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3725J@32003|Nitrosomonadales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_353055_1	1123242.JH636436_gene333	3.73e-09	57.4	COG0836@1|root,COG0836@2|Bacteria,2IXAR@203682|Planctomycetes	203682|Planctomycetes	M	Mannose-1-phosphate guanylyltransferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_353055_2	1123376.AUIU01000011_gene937	2.5e-28	110.0	COG2928@1|root,COG2928@2|Bacteria,3J0R2@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_974352_1	375286.mma_1970	1.68e-164	492.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,472J6@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_582512_1	1267005.KB911255_gene2394	3.48e-83	256.0	COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,2TTPI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Choloylglycine hydrolase	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
k59_92826_1	330214.NIDE0370	1.03e-112	337.0	COG0056@1|root,COG0056@2|Bacteria,3J0CZ@40117|Nitrospirae	40117|Nitrospirae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_773595_1	1122139.KB907864_gene2119	1.83e-21	94.4	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,1RYTA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_773595_2	1121374.KB891576_gene438	0.000232	43.9	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_745882_1	483219.LILAB_18035	1.88e-42	147.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria	1224|Proteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_745882_2	1121459.AQXE01000009_gene477	1.12e-11	65.1	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2WQ4P@28221|Deltaproteobacteria,2MCND@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_353062_2	1499967.BAYZ01000054_gene4817	2.27e-53	176.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	appB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_157473_1	96561.Dole_2493	4.68e-130	381.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,2MHRT@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM acetylornithine and succinylornithine	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204	Aminotran_3
k59_92828_1	522306.CAP2UW1_3929	4.3e-55	181.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,1KQQC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_92828_2	323848.Nmul_A1621	4.33e-08	53.5	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,37229@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_318405_2	765910.MARPU_10270	1.44e-48	165.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales	135613|Chromatiales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_614378_1	395494.Galf_0397	6.13e-101	298.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2VJ8T@28216|Betaproteobacteria,44VMJ@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
k59_801716_1	1125973.JNLC01000010_gene1358	4.69e-65	214.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JX4Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_1033747_1	1041146.ATZB01000024_gene2525	9.71e-75	230.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,4B9HM@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type molybdate transport system, permease component	modB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
k59_548818_1	1198232.CYCME_1779	2.37e-110	335.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,461RW@72273|Thiotrichales	72273|Thiotrichales	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_801773_1	1122609.AUGT01000008_gene2868	4.02e-19	93.2	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
k59_289533_2	911045.PSE_3483	1.42e-19	94.4	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2TV7R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mechanosensitive ion channel	-	-	-	ko:K16052,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3,1.A.23.4	-	-	MS_channel
k59_548859_1	1158292.JPOE01000005_gene275	1.09e-41	149.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2VTTR@28216|Betaproteobacteria,1KIVH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Tryptophan halogenase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
k59_801797_2	696281.Desru_3187	0.000457	42.0	COG1595@1|root,COG1595@2|Bacteria,1V4E2@1239|Firmicutes,24GZP@186801|Clostridia,262C3@186807|Peptococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_548883_1	1569209.BBPH01000256_gene3863	1.14e-12	68.2	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,2PVGJ@265|Paracoccus	28211|Alphaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_801833_1	1191523.MROS_0856	4.96e-21	88.6	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_554448_2	640081.Dsui_1632	1.1e-32	119.0	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria,2KX1A@206389|Rhodocyclales	206389|Rhodocyclales	S	FixH family	-	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
k59_554545_1	56107.Cylst_2729	1.31e-26	102.0	COG2852@1|root,COG2852@2|Bacteria,1GNS3@1117|Cyanobacteria,1HP42@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
k59_554572_2	880071.Fleli_1106	8.86e-14	68.6	2C9BK@1|root,32RP1@2|Bacteria,4NSPA@976|Bacteroidetes,47RVQ@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4286)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4286
k59_807701_1	396588.Tgr7_0824	1.33e-10	60.8	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales	135613|Chromatiales	T	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_807701_2	999550.KI421507_gene588	4.54e-41	153.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_807703_1	523791.Kkor_1536	2.93e-49	173.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,1RQFF@1236|Gammaproteobacteria,1XICC@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
k59_554631_1	1054213.HMPREF9946_03934	1.28e-12	67.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_554631_2	1408224.SAMCCGM7_c1040	1.91e-24	104.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,4B71V@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	NADPH quinone reductase and related Zn-dependent oxidoreductases	qor	GO:0000166,GO:0003674,GO:0003824,GO:0003960,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0010941,GO:0016491,GO:0016651,GO:0016655,GO:0019362,GO:0019637,GO:0034641,GO:0036094,GO:0042802,GO:0042803,GO:0042981,GO:0043067,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0048038,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0051186,GO:0055086,GO:0055114,GO:0065007,GO:0070402,GO:0071704,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_807749_1	631362.Thi970DRAFT_01377	4.28e-13	69.3	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,1RR1J@1236|Gammaproteobacteria,1WVZY@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_807749_2	1163617.SCD_n02705	4.06e-29	108.0	COG0316@1|root,COG0316@2|Bacteria,1N8ZN@1224|Proteobacteria,2W5FR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Iron-sulphur cluster biosynthesis	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_554640_1	290317.Cpha266_2038	1.91e-41	152.0	COG1207@1|root,COG1207@2|Bacteria,1FDS8@1090|Chlorobi	1090|Chlorobi	M	Sugar nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,NTP_transf_4
k59_807761_1	945713.IALB_2729	2.07e-41	156.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	-	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,SurA_N_3
k59_807776_1	436308.Nmar_0506	1.04e-34	124.0	arCOG03119@1|root,arCOG03119@2157|Archaea,41T0Y@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_554698_1	365044.Pnap_0425	3.59e-39	145.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2VK8B@28216|Betaproteobacteria,4ABJ1@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_807815_1	436308.Nmar_0975	5.19e-95	287.0	COG1602@1|root,arCOG04269@2157|Archaea,41S7H@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
k59_554738_1	926550.CLDAP_05500	1.15e-31	127.0	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_III,MutS_V,Smr
k59_1038302_1	438753.AZC_0555	6.67e-84	258.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2TT2W@28211|Alphaproteobacteria,3EYS7@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.2.20,4.1.2.52	ko:K01630,ko:K02510	ko00053,ko00350,ko01120,map00053,map00350,map01120	-	R01645,R01647,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_554743_1	991905.SL003B_0832	2.81e-24	98.6	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,4BRCY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	cysA	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_554743_2	62928.azo3447	9.57e-90	283.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,2KV98@206389|Rhodocyclales	206389|Rhodocyclales	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_807847_1	1380355.JNIJ01000050_gene129	3.36e-49	176.0	COG3889@1|root,COG3889@2|Bacteria,1R6EI@1224|Proteobacteria,2UQR6@28211|Alphaproteobacteria,3K2HR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_554750_1	292415.Tbd_2459	1.02e-32	124.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,1KS4T@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Phosphoribosylglycinamide synthetase, C domain	-	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_554750_2	582744.Msip34_0381	3.01e-67	219.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,2KKHT@206350|Nitrosomonadales	206350|Nitrosomonadales	F	TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_807864_1	228410.NE0993	2.49e-68	218.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,3725K@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_554760_1	385682.AFSL01000008_gene2581	2.18e-49	177.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,4NICW@976|Bacteroidetes,2G24S@200643|Bacteroidia,3XJSA@558415|Marinilabiliaceae	976|Bacteroidetes	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,PAS_9
k59_1038333_1	693977.Deipr_0286	9.35e-44	159.0	COG0651@1|root,COG0651@2|Bacteria,1WJR3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_554832_1	1380386.JIAW01000006_gene1238	3.96e-07	55.5	COG1309@1|root,COG1309@2|Bacteria,2GMBW@201174|Actinobacteria,2358A@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	icaR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1038382_1	290397.Adeh_2207	6.24e-34	130.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria	1224|Proteobacteria	H	Methyl-transferase	egtB	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
k59_808002_1	83406.HDN1F_30620	1.33e-84	265.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1J4PV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the GMC oxidoreductase family	alkJ	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_808003_1	1190603.AJYD01000026_gene3336	3.34e-62	210.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria,1XUNK@135623|Vibrionales	135623|Vibrionales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_808009_2	945713.IALB_0413	4.53e-90	277.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_554953_1	1131553.JIBI01000015_gene656	1.28e-65	217.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,3722A@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_554953_2	1123354.AUDR01000017_gene86	1.57e-17	78.6	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2VSEQ@28216|Betaproteobacteria,1KRM6@119069|Hydrogenophilales	119069|Hydrogenophilales	O	GrpE	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_554965_1	269796.Rru_A2861	2.35e-65	205.0	COG4627@1|root,COG4627@2|Bacteria,1RKW8@1224|Proteobacteria,2UA2Z@28211|Alphaproteobacteria,2JWM7@204441|Rhodospirillales	204441|Rhodospirillales	S	Pfam Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_808085_1	557598.LHK_02116	1.2e-31	116.0	2CGNP@1|root,32S4A@2|Bacteria,1N1J7@1224|Proteobacteria,2VUN9@28216|Betaproteobacteria,2KRN5@206351|Neisseriales	206351|Neisseriales	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_808085_2	228410.NE0025	5.77e-48	166.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,371M1@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_808087_4	268747.Q58LF1_BPPRS	6.85e-26	104.0	4QASV@10239|Viruses,4QWD9@35237|dsDNA viruses  no RNA stage,4QQ4N@28883|Caudovirales,4QIBN@10662|Myoviridae	10662|Myoviridae	S	recA bacterial DNA recombination protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_555006_1	45351.EDO46109	1.03e-51	189.0	KOG0621@1|root,KOG0621@2759|Eukaryota,38I3R@33154|Opisthokonta,3BBDE@33208|Metazoa	33208|Metazoa	M	phospholipid scrambling	PLSCR3	GO:0000981,GO:0000982,GO:0001077,GO:0001228,GO:0001775,GO:0002237,GO:0002252,GO:0002376,GO:0002520,GO:0002526,GO:0002682,GO:0002684,GO:0002694,GO:0003674,GO:0003700,GO:0005102,GO:0005154,GO:0005215,GO:0005319,GO:0005488,GO:0005509,GO:0005515,GO:0005548,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006575,GO:0006629,GO:0006644,GO:0006650,GO:0006658,GO:0006659,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006915,GO:0006950,GO:0006952,GO:0006953,GO:0006954,GO:0006955,GO:0007009,GO:0007154,GO:0007165,GO:0007275,GO:0007596,GO:0007599,GO:0008150,GO:0008152,GO:0008219,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009605,GO:0009607,GO:0009611,GO:0009615,GO:0009617,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010256,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010646,GO:0010647,GO:0010876,GO:0010911,GO:0010912,GO:0010941,GO:0010942,GO:0012501,GO:0012505,GO:0015711,GO:0015748,GO:0015914,GO:0016020,GO:0016021,GO:0016043,GO:0016070,GO:0017121,GO:0017124,GO:0017128,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019899,GO:0019904,GO:0023051,GO:0023052,GO:0023056,GO:0030097,GO:0030099,GO:0030154,GO:0030168,GO:0031012,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031347,GO:0031349,GO:0031974,GO:0031981,GO:0032091,GO:0032496,GO:0032501,GO:0032502,GO:0032774,GO:0032781,GO:0033003,GO:0033036,GO:0033500,GO:0033993,GO:0034097,GO:0034641,GO:0034645,GO:0034654,GO:0035455,GO:0035456,GO:0035556,GO:0042060,GO:0042221,GO:0042398,GO:0042592,GO:0042593,GO:0042609,GO:0042632,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043393,GO:0043462,GO:0043900,GO:0043901,GO:0043903,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044271,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045017,GO:0045069,GO:0045071,GO:0045088,GO:0045089,GO:0045121,GO:0045893,GO:0045935,GO:0045944,GO:0046474,GO:0046483,GO:0046486,GO:0046872,GO:0048306,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048525,GO:0048534,GO:0048583,GO:0048584,GO:0048731,GO:0048856,GO:0048869,GO:0048878,GO:0050776,GO:0050778,GO:0050789,GO:0050790,GO:0050792,GO:0050794,GO:0050817,GO:0050865,GO:0050878,GO:0050896,GO:0051098,GO:0051100,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051252,GO:0051254,GO:0051336,GO:0051345,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055088,GO:0055092,GO:0060255,GO:0060368,GO:0061024,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070782,GO:0070851,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071310,GO:0071345,GO:0071396,GO:0071702,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0090407,GO:0097035,GO:0097190,GO:0097193,GO:0097194,GO:0097659,GO:0098542,GO:0098589,GO:0098805,GO:0098857,GO:0140110,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1901701,GO:1902229,GO:1902231,GO:1902531,GO:1902533,GO:1902680,GO:1903506,GO:1903508,GO:1903900,GO:1903901,GO:2000112,GO:2000371,GO:2000373,GO:2001020,GO:2001022,GO:2001141,GO:2001233,GO:2001235,GO:2001242,GO:2001244	-	-	-	-	-	-	-	-	-	-	Scramblase
k59_808097_1	379066.GAU_3169	5.49e-116	343.0	COG0332@1|root,COG0332@2|Bacteria,1ZU9P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_808100_1	1131553.JIBI01000017_gene563	7.72e-35	137.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,371VE@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_808142_1	1207076.ALAT01000036_gene4201	8.63e-165	464.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1Z0R4@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Belongs to the KdsA family	kdsA	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008676,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016043,GO:0016051,GO:0016053,GO:0016740,GO:0016765,GO:0019294,GO:0019752,GO:0022607,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_808161_1	330214.NIDE2458	2.4e-34	129.0	COG0533@1|root,COG0533@2|Bacteria,3J0I3@40117|Nitrospirae	40117|Nitrospirae	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_808191_1	323848.Nmul_A0354	2.94e-121	355.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,372UE@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_808206_1	1122147.AUEH01000001_gene474	1.55e-44	159.0	COG0539@1|root,COG0539@2|Bacteria,1TQ9N@1239|Firmicutes,4H9PX@91061|Bacilli,3F4DQ@33958|Lactobacillaceae	91061|Bacilli	J	Ribosomal protein S1	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_808290_1	1238450.VIBNISOn1_1760055	7.56e-80	248.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1Y0M7@135623|Vibrionales	135623|Vibrionales	M	Conserved TM helix	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_808307_1	522306.CAP2UW1_0353	2.7e-140	410.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPYJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1038656_1	552811.Dehly_0649	6.38e-80	261.0	COG3039@1|root,COG4198@1|root,COG3039@2|Bacteria,COG4198@2|Bacteria,2G9US@200795|Chloroflexi,34D8F@301297|Dehalococcoidia	2|Bacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF1015,DUF772
k59_1038661_1	272134.KB731324_gene1216	2.96e-110	333.0	COG0129@1|root,COG0129@2|Bacteria,1G0KD@1117|Cyanobacteria,1H8V6@1150|Oscillatoriales	1117|Cyanobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_808338_1	399550.Smar_0687	9.09e-06	52.8	COG0591@1|root,arCOG01316@2157|Archaea,2XR75@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_808351_1	330214.NIDE3915	7.51e-122	361.0	COG1538@1|root,COG1538@2|Bacteria,3J19C@40117|Nitrospirae	40117|Nitrospirae	MU	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_808363_2	395965.Msil_2886	4.56e-42	146.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2U9UT@28211|Alphaproteobacteria,3NBAK@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_1038711_1	525897.Dbac_2881	0.000102	43.9	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria,2MB0F@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_1038711_2	666684.AfiDRAFT_1589	4.89e-47	168.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,3JQXK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1038725_1	1121127.JAFA01000065_gene4737	1.95e-61	200.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,1K1XI@119060|Burkholderiaceae	28216|Betaproteobacteria	O	XdhC and CoxI family	coxI	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_808432_2	1123257.AUFV01000008_gene586	1.94e-47	172.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1X47B@135614|Xanthomonadales	135614|Xanthomonadales	S	DNA internalization-related competence protein ComEC Rec2	comA	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_1038734_1	521719.ATXQ01000005_gene1518	2.51e-13	75.1	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,1S8ED@1236|Gammaproteobacteria,1YDIA@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_808481_1	1502770.JQMG01000001_gene608	4.52e-87	283.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,2KKG3@206350|Nitrosomonadales	206350|Nitrosomonadales	M	TIGRFAM penicillin-binding protein, 1A family	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_808545_1	671143.DAMO_2706	6.72e-107	329.0	COG1009@1|root,COG1009@2|Bacteria,2NNM8@2323|unclassified Bacteria	2|Bacteria	CP	NADH-quinone oxidoreductase chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1038852_1	983917.RGE_44900	6.27e-88	271.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,1KK8T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
k59_808638_1	7213.XP_004532366.1	1.04e-11	63.9	COG0486@1|root,KOG1191@2759|Eukaryota,39Y5T@33154|Opisthokonta,3BNTI@33208|Metazoa	33208|Metazoa	J	Ferrous iron transport protein B	-	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_808638_2	1163617.SCD_n01806	1.76e-82	256.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_1038931_1	401526.TcarDRAFT_1865	1.84e-71	226.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4H3R9@909932|Negativicutes	909932|Negativicutes	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_808719_1	580332.Slit_1711	2.39e-110	343.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,44WAX@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_197827_1	1123256.KB907926_gene668	6.05e-50	177.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1X31T@135614|Xanthomonadales	135614|Xanthomonadales	OU	signal peptide peptidase	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_850546_2	1031711.RSPO_c02300	5.8e-43	147.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2VHY7@28216|Betaproteobacteria,1K06W@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
k59_524270_1	349163.Acry_2092	2.33e-12	72.0	COG1716@1|root,COG3456@1|root,COG1716@2|Bacteria,COG3456@2|Bacteria,1R3R7@1224|Proteobacteria,2TUSB@28211|Alphaproteobacteria,2JW3T@204441|Rhodospirillales	204441|Rhodospirillales	T	Forkhead associated domain	-	-	-	ko:K11894	-	-	-	-	ko00000,ko02044	3.A.23.1	-	-	FHA
k59_818247_1	1120792.JAFV01000001_gene3898	1.24e-76	245.0	COG0747@1|root,COG0747@2|Bacteria,1MWR7@1224|Proteobacteria,2TS51@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	MA20_22710	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5,TAT_signal
k59_557059_1	745310.G432_17600	4.44e-24	104.0	COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,2TW6R@28211|Alphaproteobacteria,2K3JU@204457|Sphingomonadales	204457|Sphingomonadales	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3
k59_948591_1	472759.Nhal_0582	1.53e-55	178.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1WX8C@135613|Chromatiales	135613|Chromatiales	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_426182_1	1187851.A33M_2603	6.82e-13	67.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3FD1Y@34008|Rhodovulum	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_426182_2	1298867.AUES01000026_gene3023	3.54e-60	195.0	COG0411@1|root,COG0411@2|Bacteria,1R3YN@1224|Proteobacteria,2U2IG@28211|Alphaproteobacteria,3JXXI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
k59_263162_1	887062.HGR_03867	4.36e-12	63.2	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2VSJV@28216|Betaproteobacteria,4ADN2@80864|Comamonadaceae	28216|Betaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_263162_2	1265502.KB905966_gene1210	5.1e-107	322.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,4AAYA@80864|Comamonadaceae	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_687646_1	69328.PVLB_00585	2.15e-66	213.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_524289_1	933262.AXAM01000002_gene501	1.75e-92	283.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria,2MI35@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_720163_1	312153.Pnuc_1158	1.47e-58	202.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1JZMH@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_295656_1	1000565.METUNv1_00673	2.95e-09	57.4	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,2KVDU@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
k59_295656_2	525897.Dbac_3070	3.37e-13	72.0	COG1450@1|root,COG1450@2|Bacteria,1NC06@1224|Proteobacteria	1224|Proteobacteria	NU	Type ii and iii secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,Secretin_N
k59_687651_1	1121440.AUMA01000014_gene1924	6.86e-13	73.9	COG2931@1|root,COG4254@1|root,COG2931@2|Bacteria,COG4254@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2WMD9@28221|Deltaproteobacteria,2M8AQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Hemolysin-type calcium-binding region	-	-	-	-	-	-	-	-	-	-	-	-	FecR,HemolysinCabind,VWA,VWA_2
k59_34607_1	935845.JADQ01000020_gene4199	1.48e-13	73.2	COG0667@1|root,COG0667@2|Bacteria,1UKPC@1239|Firmicutes,4HCHM@91061|Bacilli,26QKW@186822|Paenibacillaceae	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_34607_2	1336243.JAEA01000001_gene1814	1.6e-63	205.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TYVX@28211|Alphaproteobacteria,1JSWN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_1824_1	882.DVU_1851	1.51e-56	192.0	COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria,2M7ZK@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_557089_1	330214.NIDE3937	9.66e-116	367.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
k59_916221_1	83406.HDN1F_00590	2.76e-115	338.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1J4VP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760	Coprogen_oxidas
k59_1831_1	1387312.BAUS01000001_gene1343	8.45e-33	125.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,2VRRA@28216|Betaproteobacteria,2KP9X@206350|Nitrosomonadales	206350|Nitrosomonadales	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_426217_2	1163617.SCD_n01118	7.97e-83	252.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VQ3B@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_883142_1	1120956.JHZK01000003_gene413	4.83e-91	274.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,1JNBJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	AAA domain (dynein-related subfamily)	MA20_09400	-	-	-	-	-	-	-	-	-	-	-	AAA_5
k59_67315_1	933262.AXAM01000015_gene116	1.58e-41	153.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MIBD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_622274_1	1333998.M2A_0365	3.67e-90	275.0	COG1633@1|root,COG1633@2|Bacteria,1R02H@1224|Proteobacteria,2TYHQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
k59_263198_1	1509405.GV67_03245	1.6e-48	167.0	COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,2U66Q@28211|Alphaproteobacteria,4B9R5@82115|Rhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_263198_2	1121861.KB899920_gene2890	2.51e-48	165.0	COG0596@1|root,COG0596@2|Bacteria,1NJ2B@1224|Proteobacteria,2TR54@28211|Alphaproteobacteria,2JV21@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_426231_1	880073.Calab_0923	1.53e-17	87.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	ebh	-	-	-	-	-	-	-	-	-	-	-	DUF1611,Inhibitor_I9,Peptidase_S8,SLH
k59_916237_1	1173024.KI912148_gene3523	1.39e-90	280.0	COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria	1117|Cyanobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	cobW
k59_948650_1	1123276.KB893251_gene3581	2.5e-06	50.1	COG0300@1|root,COG0300@2|Bacteria,4NEMK@976|Bacteroidetes,47JGN@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_197893_1	1121405.dsmv_0205	4.07e-25	109.0	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MI01@213118|Desulfobacterales	28221|Deltaproteobacteria	S	metal-dependent phosphohydrolase 7TM intracellular region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_67330_1	596154.Alide2_1066	1.78e-31	124.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VJNE@28216|Betaproteobacteria,4ACWM@80864|Comamonadaceae	28216|Betaproteobacteria	C	Homoaconitate hydratase family protein	leuC1	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_916241_1	62928.azo1947	3.67e-85	256.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,2KXUS@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S binding domain	-	-	-	ko:K18362	ko00360,map00360	-	R07222,R07294	RC00004,RC01844,RC01903	ko00000,ko00001	-	-	-	-
k59_263213_1	765420.OSCT_2170	3.65e-09	57.4	COG1595@1|root,COG1595@2|Bacteria,2G6PJ@200795|Chloroflexi,375U9@32061|Chloroflexia	32061|Chloroflexia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_916245_1	1123023.JIAI01000002_gene4751	9.96e-75	234.0	COG4948@1|root,COG4948@2|Bacteria,2GT81@201174|Actinobacteria,4E10Q@85010|Pseudonocardiales	201174|Actinobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.156,4.2.1.42	ko:K20023	ko00053,map00053	-	R05608	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_916245_2	580332.Slit_2516	4.07e-09	54.7	COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,2VUM5@28216|Betaproteobacteria,44VVX@713636|Nitrosomonadales	28216|Betaproteobacteria	S	membrane	yqaA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_850620_1	742738.HMPREF9460_02759	1.27e-11	70.1	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,267UY@186813|unclassified Clostridiales	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_948662_1	330214.NIDE0608	1.11e-60	199.0	COG1005@1|root,COG1005@2|Bacteria,3J0E2@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_752499_1	228410.NE2391	1.83e-56	192.0	COG1477@1|root,COG2991@1|root,COG1477@2|Bacteria,COG2991@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,371SS@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_850622_1	436308.Nmar_0001	5.29e-53	177.0	COG1474@1|root,arCOG00467@2157|Archaea,41SED@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
k59_850622_2	436308.Nmar_0002	6.1e-53	178.0	COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B
k59_165205_1	983917.RGE_20990	3.75e-112	333.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2VKUY@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_752501_1	96561.Dole_0888	8.02e-73	238.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria,2MMH4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
k59_916258_1	400682.PAC_15710327	1.8e-34	128.0	COG4579@1|root,2S4PR@2759|Eukaryota,39ZYX@33154|Opisthokonta,3BPWJ@33208|Metazoa	33208|Metazoa	T	Isocitrate dehydrogenase kinase/phosphatase (AceK)	-	-	-	-	-	-	-	-	-	-	-	-	AceK
k59_752503_1	76114.ebA1283	2.81e-32	123.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,2KV5H@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the peptidase S1C family	-	-	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_752503_2	1163617.SCD_n00597	1.2e-38	137.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_981227_1	977880.RALTA_A1395	1.68e-85	273.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2VJZW@28216|Betaproteobacteria,1K3Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
k59_557140_1	768710.DesyoDRAFT_3462	2.75e-40	149.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
k59_524355_1	338966.Ppro_0061	2.4e-49	175.0	COG1132@1|root,COG1132@2|Bacteria,1MXC2@1224|Proteobacteria,42PQK@68525|delta/epsilon subdivisions,2WJCT@28221|Deltaproteobacteria,43T12@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_263235_1	382464.ABSI01000010_gene3669	4.15e-29	111.0	COG1622@1|root,COG1622@2|Bacteria,46SPQ@74201|Verrucomicrobia,2IU8P@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	COX2
k59_263235_2	382464.ABSI01000010_gene3668	5.16e-26	107.0	COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia,2ITKY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
k59_458837_1	56780.SYN_02371	1.84e-96	294.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MQ94@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_230337_1	1500897.JQNA01000002_gene396	1.25e-103	323.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,1K41J@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_557149_1	485913.Krac_4763	1.24e-55	189.0	COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_328423_1	1499689.CCNN01000014_gene3273	2.01e-53	175.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia,36FEF@31979|Clostridiaceae	186801|Clostridia	P	Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
k59_328423_2	1123075.AUDP01000022_gene3650	0.000117	45.1	COG0407@1|root,COG0407@2|Bacteria,1V5GX@1239|Firmicutes	1239|Firmicutes	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_850647_1	1116472.MGMO_149c00020	9.57e-37	129.0	2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,1S80C@1236|Gammaproteobacteria,1XFEZ@135618|Methylococcales	135618|Methylococcales	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
k59_850647_2	1163617.SCD_n00185	1.94e-20	87.4	COG5662@1|root,COG5662@2|Bacteria,1RK1X@1224|Proteobacteria,2VQDP@28216|Betaproteobacteria	28216|Betaproteobacteria	K	transmembrane transcriptional regulator (Anti-sigma factor)	prtR	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
k59_295731_1	1382306.JNIM01000001_gene631	8.94e-25	103.0	COG1691@1|root,COG1691@2|Bacteria,2G6SZ@200795|Chloroflexi	200795|Chloroflexi	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
k59_981238_2	640081.Dsui_1221	1.83e-18	80.1	2E7W9@1|root,332AX@2|Bacteria,1NAZ7@1224|Proteobacteria,2VVY9@28216|Betaproteobacteria,2KXPE@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_784263_1	1232410.KI421425_gene1543	1.73e-57	192.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,43SUP@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
k59_197933_1	487521.OCU_27710	3.63e-46	164.0	COG4638@1|root,COG4638@2|Bacteria,2GM3P@201174|Actinobacteria,233JP@1762|Mycobacteriaceae	201174|Actinobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
k59_883202_1	760117.JN27_12845	6.29e-46	155.0	COG1051@1|root,COG1051@2|Bacteria,1QX1G@1224|Proteobacteria,2VWUH@28216|Betaproteobacteria,477F3@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_426287_1	926569.ANT_09980	2.05e-59	208.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_687758_1	580332.Slit_2634	6.47e-75	245.0	COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,2WHEY@28216|Betaproteobacteria,44V0X@713636|Nitrosomonadales	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_8
k59_948704_1	987059.RBXJA2T_03733	2.27e-25	109.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria,1KJ09@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,Glyco_hydro_77
k59_948704_2	1163617.SCD_n01925	2.12e-114	341.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1012942_2	622637.KE124770_gene148	5.57e-31	122.0	COG1389@1|root,COG1389@2|Bacteria,1R6T0@1224|Proteobacteria	1224|Proteobacteria	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
k59_883214_1	314278.NB231_13251	4.05e-19	88.2	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RCFZ@1224|Proteobacteria,1S2QS@1236|Gammaproteobacteria,1X1B9@135613|Chromatiales	135613|Chromatiales	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_752535_1	479434.Sthe_0368	3.13e-05	48.9	COG5002@1|root,COG5002@2|Bacteria,2G67W@200795|Chloroflexi,27XFQ@189775|Thermomicrobia	189775|Thermomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
k59_752535_2	999411.HMPREF1092_00949	1.11e-26	104.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,36ESG@31979|Clostridiaceae	186801|Clostridia	T	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_819574_1	1123504.JQKD01000012_gene1305	7.31e-37	135.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4AGIR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_101127_1	1163617.SCD_n01470	3.68e-145	447.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_459822_1	948106.AWZT01000006_gene3265	1.21e-47	164.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,1K0HU@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroG	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_459822_2	887898.HMPREF0551_1669	2.5e-35	129.0	COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,2VX3A@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_602617_2	1184267.A11Q_1833	1.67e-128	389.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2MTH2@213481|Bdellovibrionales,2WIIV@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	aconitate hydratase	aco	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_701218_1	1286106.MPL1_07942	2.6e-27	116.0	COG1361@1|root,COG1361@2|Bacteria,1QV4I@1224|Proteobacteria,1T281@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_993756_1	1411123.JQNH01000001_gene72	1.71e-41	148.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
k59_145662_1	1123366.TH3_08489	1.5e-38	145.0	COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,2JQ75@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_145662_2	1232683.ADIMK_3475	1.65e-40	143.0	COG0601@1|root,COG0601@2|Bacteria,1MWXF@1224|Proteobacteria,1RSBZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_831735_1	926556.Echvi_4590	6.76e-68	221.0	COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes	976|Bacteroidetes	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_570339_1	290512.Paes_1613	1.79e-30	116.0	COG0702@1|root,COG0702@2|Bacteria,1FE8P@1090|Chlorobi	1090|Chlorobi	C	PFAM NADH ubiquinone oxidoreductase complex I intermediate-associated protein 30	-	-	-	-	-	-	-	-	-	-	-	-	CIA30
k59_831739_1	1123487.KB892864_gene2129	7.32e-33	125.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2WA5U@28216|Betaproteobacteria,2KXHH@206389|Rhodocyclales	206389|Rhodocyclales	S	TraB family	-	-	-	-	-	-	-	-	-	-	-	-	TraB
k59_602636_2	880071.Fleli_1928	1.09e-08	60.8	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,4NKPG@976|Bacteroidetes,47TCB@768503|Cytophagia	976|Bacteroidetes	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_929533_1	1185652.USDA257_c26720	4.37e-80	254.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TUN5@28211|Alphaproteobacteria,4BCAP@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Amino acid permease	-	-	-	ko:K03294,ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.2,2.A.3.5	-	-	AA_permease_2
k59_531633_1	330214.NIDE3303	8.18e-27	109.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
k59_47550_1	945713.IALB_0138	1.5e-133	389.0	COG0635@1|root,COG0635@2|Bacteria	2|Bacteria	H	coproporphyrinogen oxidase activity	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_240871_1	314345.SPV1_03033	7.25e-76	234.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria	1224|Proteobacteria	T	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_240871_2	272569.rrnAC3101	2.41e-05	48.1	COG0500@1|root,arCOG01783@2157|Archaea,2XV4B@28890|Euryarchaeota,23TXK@183963|Halobacteria	183963|Halobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_993787_1	305700.B447_10323	5.79e-67	224.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,2KVIF@206389|Rhodocyclales	206389|Rhodocyclales	NU	COG1450 Type II secretory pathway, component PulD	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_240876_1	757424.Hsero_2167	3.18e-90	286.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,47338@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_788551_1	909613.UO65_1685	4.75e-28	115.0	COG0654@1|root,COG1028@1|root,COG0654@2|Bacteria,COG1028@2|Bacteria,2GK88@201174|Actinobacteria,4E1IJ@85010|Pseudonocardiales	201174|Actinobacteria	CH	FAD binding domain	-	-	-	ko:K15927,ko:K15930	ko01057,ko01130,map01057,map01130	-	R06656,R09342,R09346	RC00046,RC02488,RC02489	ko00000,ko00001	-	-	-	FAD_binding_3,adh_short_C2
k59_788551_2	512565.AMIS_18260	2.47e-09	57.4	COG0702@1|root,COG0702@2|Bacteria,2GK1A@201174|Actinobacteria,4DGQQ@85008|Micromonosporales	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
k59_962136_1	324925.Ppha_1651	1.17e-07	50.8	2EGA9@1|root,33A23@2|Bacteria,1FFKZ@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_962136_2	1121405.dsmv_1358	3.19e-33	117.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42W2F@68525|delta/epsilon subdivisions,2WRUM@28221|Deltaproteobacteria,2MKSW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	ihfA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_668467_2	323848.Nmul_A1095	3.12e-78	236.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2VQD9@28216|Betaproteobacteria,371SU@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_570385_1	66897.DJ64_34540	1.96e-16	83.2	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_635100_1	497964.CfE428DRAFT_0911	2.87e-62	199.0	COG0518@1|root,COG0518@2|Bacteria,46V9Z@74201|Verrucomicrobia	74201|Verrucomicrobia	F	PFAM glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
k59_145712_1	426117.M446_2595	2.56e-09	58.9	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,1JS2B@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_145712_2	648757.Rvan_0944	2.41e-41	149.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,3N6J2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_668471_1	595460.RRSWK_00865	7.34e-19	87.4	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_570389_1	1123393.KB891316_gene2124	1.97e-29	108.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,1KTBP@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
k59_113054_1	1187851.A33M_0979	3.76e-105	315.0	COG1305@1|root,COG1305@2|Bacteria,1MY5V@1224|Proteobacteria,2TU99@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	TAT_signal,Transglut_core
k59_469283_1	1123250.KB908407_gene2222	7.42e-15	77.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,4H420@909932|Negativicutes	909932|Negativicutes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_240892_1	323848.Nmul_A2238	6.43e-101	303.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,371YB@32003|Nitrosomonadales	28216|Betaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_570395_1	1123367.C666_14400	1.37e-20	85.1	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria,2KWFV@206389|Rhodocyclales	206389|Rhodocyclales	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
k59_570395_2	272943.RSP_3143	2.08e-35	124.0	2E5W4@1|root,330K6@2|Bacteria,1N893@1224|Proteobacteria,2UGUZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
k59_570395_3	1095769.CAHF01000022_gene349	2.29e-28	112.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2VPP7@28216|Betaproteobacteria,4724Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
k59_210592_1	420662.Mpe_A1634	7.63e-133	388.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VM67@28216|Betaproteobacteria,1KJ85@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_15367_2	237368.SCABRO_03897	3.61e-45	153.0	COG4976@1|root,COG4976@2|Bacteria	2|Bacteria	O	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
k59_145730_1	546262.NEICINOT_04589	6.87e-96	291.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,2KPH1@206351|Neisseriales	206351|Neisseriales	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_404135_1	323850.Shew_0020	7.34e-47	166.0	COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,2Q948@267890|Shewanellaceae	1236|Gammaproteobacteria	E	Splits dipeptides with a prolyl residue in the C- terminal position	pepQ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_993826_1	1121931.AUHG01000013_gene2455	3.49e-17	86.3	COG3209@1|root,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ7S@117743|Flavobacteriia	976|Bacteroidetes	M	SPTR CHU large protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,HYR,Laminin_G_3,SprB
k59_469299_2	1121127.JAFA01000003_gene1908	1.4e-29	116.0	COG0492@1|root,COG0492@2|Bacteria,1MVX2@1224|Proteobacteria,2VM3V@28216|Betaproteobacteria,1K4AE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
k59_505149_1	1459636.NTE_02735	4.1e-90	283.0	COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the MCM family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
k59_668512_1	1121413.JMKT01000009_gene1954	4.47e-41	154.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
k59_240918_1	1506583.JQJY01000003_gene3598	3.45e-18	82.0	COG1309@1|root,COG1309@2|Bacteria,4NP1K@976|Bacteroidetes,1I2H0@117743|Flavobacteriia,2NV4V@237|Flavobacterium	976|Bacteroidetes	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
k59_668516_1	243090.RB783	1.07e-98	297.0	COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes	203682|Planctomycetes	P	COG0798 Arsenite efflux pump ACR3 and related	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_602718_1	945713.IALB_0978	7.16e-41	146.0	COG2971@1|root,COG2971@2|Bacteria	2|Bacteria	G	N-acetylglucosamine kinase activity	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363	2.7.1.59	ko:K00884	ko00520,ko01100,map00520,map01100	-	R01201	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	BcrAD_BadFG
k59_178321_1	1266914.ATUK01000014_gene2206	4.56e-23	97.1	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1WW7B@135613|Chromatiales	135613|Chromatiales	C	reductase, alpha subunit	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_178321_2	1158756.AQXQ01000012_gene1999	9.36e-77	230.0	COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria,1RXXW@1236|Gammaproteobacteria,1WVWW@135613|Chromatiales	135613|Chromatiales	C	reductase beta subunit	-	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
k59_505155_1	1158165.KB898871_gene2150	2.7e-77	239.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1WWYC@135613|Chromatiales	135613|Chromatiales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_896581_1	498761.HM1_2196	2.54e-27	103.0	COG0838@1|root,COG0838@2|Bacteria,1V6P3@1239|Firmicutes,24MPD@186801|Clostridia	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_833080_1	1121127.JAFA01000006_gene5482	3.27e-178	512.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VI6D@28216|Betaproteobacteria,1K5TM@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_342568_1	1122169.AREN01000005_gene1867	7.9e-22	99.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,1JDBA@118969|Legionellales	118969|Legionellales	N	Bacterial flagellin N-terminal helical region	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
k59_571651_1	1121097.JCM15093_3495	2.34e-09	56.6	COG3169@1|root,COG3169@2|Bacteria,4NQH4@976|Bacteroidetes,2FT44@200643|Bacteroidia,4AQJ3@815|Bacteroidaceae	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
k59_571651_2	452637.Oter_0886	1.89e-10	61.2	COG0468@1|root,COG0468@2|Bacteria,46SIZ@74201|Verrucomicrobia,3K737@414999|Opitutae	414999|Opitutae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_342579_1	945713.IALB_1051	5.23e-69	218.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA
k59_702577_1	2340.JV46_17100	2.19e-104	325.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1J4W4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_81996_1	13684.SNOT_12240	6.32e-39	151.0	COG0514@1|root,KOG0351@2759|Eukaryota,38DX0@33154|Opisthokonta,3NWE6@4751|Fungi,3QMPG@4890|Ascomycota,2013J@147541|Dothideomycetes,4KERQ@92860|Pleosporales	4751|Fungi	A	RQC	SGS1	GO:0000003,GO:0000018,GO:0000019,GO:0000070,GO:0000075,GO:0000077,GO:0000166,GO:0000228,GO:0000278,GO:0000280,GO:0000706,GO:0000722,GO:0000723,GO:0000724,GO:0000725,GO:0000729,GO:0000819,GO:0001302,GO:0003006,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0005730,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006265,GO:0006268,GO:0006275,GO:0006281,GO:0006301,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007093,GO:0007346,GO:0007530,GO:0007531,GO:0007533,GO:0007534,GO:0007568,GO:0007569,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009378,GO:0009411,GO:0009416,GO:0009628,GO:0009889,GO:0009892,GO:0009987,GO:0010520,GO:0010556,GO:0010564,GO:0010605,GO:0010639,GO:0010946,GO:0010947,GO:0010948,GO:0016043,GO:0016233,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022402,GO:0022413,GO:0022414,GO:0022616,GO:0030154,GO:0030554,GO:0031292,GO:0031297,GO:0031323,GO:0031324,GO:0031326,GO:0031422,GO:0031570,GO:0031573,GO:0031860,GO:0031974,GO:0031981,GO:0032200,GO:0032392,GO:0032502,GO:0032505,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033043,GO:0033260,GO:0033262,GO:0033554,GO:0034641,GO:0034644,GO:0034645,GO:0035639,GO:0035822,GO:0035861,GO:0036094,GO:0040020,GO:0042592,GO:0042623,GO:0043007,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043570,GO:0043596,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044773,GO:0044774,GO:0044786,GO:0045005,GO:0045128,GO:0045132,GO:0045165,GO:0045786,GO:0045835,GO:0045910,GO:0045930,GO:0045934,GO:0046483,GO:0048285,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051276,GO:0051321,GO:0051445,GO:0051447,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0060249,GO:0060255,GO:0060631,GO:0065007,GO:0065008,GO:0070013,GO:0070035,GO:0070914,GO:0071103,GO:0071139,GO:0071140,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090329,GO:0090734,GO:0097159,GO:0097367,GO:0098813,GO:0104004,GO:0110029,GO:0140013,GO:0140014,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1902298,GO:1902969,GO:1903046,GO:1903047,GO:1903221,GO:1903463,GO:1990426,GO:1990505,GO:2000112,GO:2000241,GO:2000242	3.6.4.12	ko:K10901	ko03440,ko03460,map03440,map03460	M00295,M00414	-	-	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD,HRDC,Helicase_C,Helicase_Sgs1,RQC,RecQ_Zn_bind
k59_506369_1	396588.Tgr7_3240	7.18e-66	210.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales	135613|Chromatiales	C	PFAM Phosphoribulokinase uridine kinase	-	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_1019942_1	1408224.SAMCCGM7_c4032	2.85e-46	174.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_833097_1	323097.Nham_0803	5.42e-31	130.0	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,2TRNA@28211|Alphaproteobacteria,3JW7V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	KL	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
k59_114311_1	261292.Nit79A3_0138	6.27e-164	469.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_32
k59_179523_1	35841.BT1A1_0736	1.32e-08	58.5	COG1175@1|root,COG1175@2|Bacteria,1UVVT@1239|Firmicutes,4HCKP@91061|Bacilli,1ZQ7M@1386|Bacillus	91061|Bacilli	G	COG1175 ABC-type sugar transport systems, permease components	-	-	-	ko:K17316	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
k59_179523_2	1121377.KB906400_gene1256	1.04e-12	68.9	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
k59_506385_1	1232437.KL661965_gene3270	1.35e-84	271.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MJNF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_440003_1	436308.Nmar_0651	4.99e-89	289.0	COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota	651137|Thaumarchaeota	D	SMC proteins Flexible Hinge Domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_308891_1	305700.B447_17983	3.99e-95	283.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,2KVHW@206389|Rhodocyclales	206389|Rhodocyclales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
k59_963436_1	1424334.W822_17565	2.15e-45	160.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,3T21B@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_963436_2	1207076.ALAT01000225_gene707	1.6e-08	55.5	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,1RQIK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols	ligB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0036238,GO:0042537,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	iJN746.PP_2518	LigA,LigB
k59_211825_1	76114.ebA6481	6.65e-90	278.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,2KUIZ@206389|Rhodocyclales	206389|Rhodocyclales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_48820_1	1268622.AVS7_02972	6.23e-27	107.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,4ACU4@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_48820_2	331869.BAL199_03574	1.32e-76	239.0	COG1638@1|root,COG1638@2|Bacteria,1PG0D@1224|Proteobacteria,2TTUQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_702603_1	439481.Aboo_0247	4.85e-10	67.4	COG3039@1|root,arCOG02751@2157|Archaea	2157|Archaea	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_506398_1	509191.AEDB02000094_gene4290	7.37e-36	142.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,PP-binding,ketoacyl-synt
k59_346053_1	1123367.C666_17010	2.49e-108	322.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,2KVAQ@206389|Rhodocyclales	206389|Rhodocyclales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_276266_1	706587.Desti_2892	9.53e-29	115.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_276266_2	439235.Dalk_3802	9.49e-33	121.0	COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,42PNV@68525|delta/epsilon subdivisions,2WJVJ@28221|Deltaproteobacteria,2MK8B@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_836720_1	483219.LILAB_33440	2.53e-36	129.0	COG1595@1|root,COG1595@2|Bacteria,1RINW@1224|Proteobacteria,4385N@68525|delta/epsilon subdivisions,2X3FI@28221|Deltaproteobacteria,2YVVV@29|Myxococcales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
k59_408230_1	1523503.JPMY01000046_gene1284	2.21e-45	162.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1S1YQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1283 Na phosphate symporter	yjbB	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_868124_1	330214.NIDE0686	1.1e-20	95.9	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3J10H@40117|Nitrospirae	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,MEDS,PAS_4,PAS_9,Response_reg
k59_509939_1	1125863.JAFN01000001_gene1563	2.17e-86	260.0	COG1305@1|root,COG1305@2|Bacteria,1R9XR@1224|Proteobacteria,42QTZ@68525|delta/epsilon subdivisions,2WMV1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_673405_1	4565.EPlTAEP00000010100	8.01e-94	296.0	COG1007@1|root,KOG4668@2759|Eukaryota,37NNE@33090|Viridiplantae,3GBUN@35493|Streptophyta,3KM7Q@4447|Liliopsida,3IE0D@38820|Poales	35493|Streptophyta	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	-	-	1.6.5.3	ko:K03883	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
k59_117878_1	204773.HEAR0416	1.64e-28	109.0	29717@1|root,2ZU9N@2|Bacteria,1RJ7P@1224|Proteobacteria,2VT23@28216|Betaproteobacteria,474HM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	tctB4	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_473338_1	526227.Mesil_2700	6.39e-51	175.0	COG3552@1|root,COG3552@2|Bacteria	2|Bacteria	S	VWA domain containing CoxE-like protein	coxE	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_533882_1	1163617.SCD_n01434	7.07e-12	66.6	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1MUAK@1224|Proteobacteria,2WGJC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_533882_2	1163617.SCD_n01435	1.49e-115	337.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria	28216|Betaproteobacteria	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_998558_1	999141.GME_03827	1.96e-21	92.8	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XII4@135619|Oceanospirillales	135619|Oceanospirillales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_998558_2	1268237.G114_11605	5.03e-27	109.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1Y3DJ@135624|Aeromonadales	135624|Aeromonadales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_934471_1	330214.NIDE0546	2.25e-58	200.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_378095_1	1242864.D187_001830	3.36e-44	163.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2YWHV@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12
k59_85635_1	1288494.EBAPG3_330	8.07e-145	420.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2VJMX@28216|Betaproteobacteria,3724U@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_967085_1	1095769.CAHF01000014_gene3041	9.51e-41	140.0	COG3807@1|root,COG3807@2|Bacteria,1MZIA@1224|Proteobacteria,2VUTD@28216|Betaproteobacteria,474KS@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_4
k59_639807_1	323848.Nmul_A2758	2.47e-76	241.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2VKNE@28216|Betaproteobacteria,372VG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_998569_1	644966.Tmar_0947	5.98e-55	186.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,3WCVT@538999|Clostridiales incertae sedis	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_117894_1	521674.Plim_3990	1.84e-14	74.7	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_117894_2	502025.Hoch_2421	5.95e-44	152.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,42RCU@68525|delta/epsilon subdivisions,2X2M1@28221|Deltaproteobacteria,2Z04Y@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_1021582_1	330214.NIDE4322	1.59e-70	220.0	COG0744@1|root,COG0744@2|Bacteria,3J127@40117|Nitrospirae	40117|Nitrospirae	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_738670_1	290397.Adeh_2746	1.02e-44	159.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2YXTZ@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_52226_1	1170562.Cal6303_0240	1.31e-86	271.0	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1HU7J@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_20
k59_20217_1	313628.LNTAR_23894	9.62e-73	239.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_244991_1	983544.Lacal_2815	9.01e-19	92.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,4NK0H@976|Bacteroidetes,1IKC0@117743|Flavobacteriia	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
k59_639820_2	330214.NIDE0808	3.69e-62	197.0	2EGFY@1|root,33A7X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_836775_1	526222.Desal_3328	2.19e-18	89.4	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,1NRP8@1224|Proteobacteria,42PU4@68525|delta/epsilon subdivisions,2WMBQ@28221|Deltaproteobacteria,2M8GC@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_934493_1	522306.CAP2UW1_2800	1.05e-41	154.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_738680_1	987059.RBXJA2T_12127	2.39e-23	99.4	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,1KMIY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	rubredoxin	rubA	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
k59_244994_1	1121033.AUCF01000008_gene5677	2.72e-51	168.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VGB4@28211|Alphaproteobacteria,2JS51@204441|Rhodospirillales	204441|Rhodospirillales	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_244994_2	314271.RB2654_01215	1.95e-64	201.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2U70V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	-	-	-	-	-	-	-	-	-	Macro
k59_967102_1	1158294.JOMI01000002_gene2825	1.58e-30	113.0	COG0394@1|root,COG0394@2|Bacteria,4NNQZ@976|Bacteroidetes,2FM80@200643|Bacteroidia	976|Bacteroidetes	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ptpA	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_967102_2	90814.KL370892_gene2277	2.21e-63	197.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,462A4@72273|Thiotrichales	72273|Thiotrichales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_183001_1	375286.mma_2985	3.44e-41	148.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,472TQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_183001_2	666681.M301_2346	1.21e-71	228.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,2VK0H@28216|Betaproteobacteria,2KKB5@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_443440_1	644283.Micau_3452	2.05e-70	224.0	COG0714@1|root,COG0714@2|Bacteria,2GMBP@201174|Actinobacteria,4D8YE@85008|Micromonosporales	201174|Actinobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
k59_378138_1	1245469.S58_67060	2.29e-28	109.0	COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,2TSQ1@28211|Alphaproteobacteria,3JRBU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_19265	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_378138_2	279238.Saro_2859	7e-16	75.9	COG0596@1|root,COG0596@2|Bacteria,1R3U1@1224|Proteobacteria,2TVFV@28211|Alphaproteobacteria,2KAG5@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_183013_1	945713.IALB_1469	3.39e-74	234.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
k59_934515_1	582744.Msip34_0992	2.65e-161	464.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,2KKN0@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_312148_1	330214.NIDE2812	1.18e-37	132.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	DUF4041,GGDEF,HATPase_c,HisKA,Response_reg,T5orf172,dCache_1
k59_443457_1	1173020.Cha6605_3584	1.57e-12	72.0	COG0857@1|root,COG0857@2|Bacteria,1G0QB@1117|Cyanobacteria	1117|Cyanobacteria	C	BioD-like N-terminal domain of phosphotransacetylase	pta	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
k59_85684_1	1502770.JQMG01000001_gene1014	1.07e-103	317.0	COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VMD2@28216|Betaproteobacteria,2KKBN@206350|Nitrosomonadales	206350|Nitrosomonadales	U	PFAM Sporulation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,SPOR
k59_86782_1	1223542.GM1_016_00720	1.1e-13	77.4	COG1105@1|root,COG1105@2|Bacteria,2GK7E@201174|Actinobacteria,4GA6R@85026|Gordoniaceae	201174|Actinobacteria	H	pfkB family carbohydrate kinase	fruK	-	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_409200_1	411479.BACUNI_04297	5.33e-26	112.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,4NEK3@976|Bacteroidetes,2FPEG@200643|Bacteroidia,4ANMY@815|Bacteroidaceae	976|Bacteroidetes	C	FAD binding domain	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_511121_1	936455.KI421499_gene4168	8.9e-28	116.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_608570_3	365044.Pnap_1254	3.91e-12	63.5	2DVDD@1|root,32UZ7@2|Bacteria,1NGRW@1224|Proteobacteria,2VY85@28216|Betaproteobacteria,4AEXN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2933)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2933
k59_608570_4	1469607.KK073765_gene6508	5.53e-40	138.0	COG2020@1|root,COG2020@2|Bacteria,1G383@1117|Cyanobacteria	1117|Cyanobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
k59_379139_1	1286093.C266_14407	4.23e-42	145.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VJA0@28216|Betaproteobacteria,1K2MJ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Amino acid amide ABC transporter ATP-binding protein 2, HAAT family	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_379139_2	1207063.P24_08014	1.98e-13	70.1	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2TRWV@28211|Alphaproteobacteria,2JR5W@204441|Rhodospirillales	204441|Rhodospirillales	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_739833_1	1349822.NSB1T_03255	3.09e-08	55.8	COG4770@1|root,COG4770@2|Bacteria,4NSWV@976|Bacteroidetes,2FRYI@200643|Bacteroidia,22YBV@171551|Porphyromonadaceae	976|Bacteroidetes	I	Biofilm PGA synthesis protein PgaD	mmdC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
k59_245962_1	395493.BegalDRAFT_1244	1.95e-67	209.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,460XQ@72273|Thiotrichales	72273|Thiotrichales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_739840_1	926569.ANT_11490	7.18e-80	255.0	COG1807@1|root,COG1807@2|Bacteria,2G9HX@200795|Chloroflexi	200795|Chloroflexi	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_216397_2	269796.Rru_A1604	4.57e-10	62.8	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2TVJ1@28211|Alphaproteobacteria,2JQZS@204441|Rhodospirillales	204441|Rhodospirillales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_869301_1	1122211.JMLW01000001_gene2380	1.25e-06	52.4	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XINN@135619|Oceanospirillales	135619|Oceanospirillales	T	response regulator	-	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_86816_1	370438.PTH_1132	8.25e-64	207.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,25ZZM@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_968278_1	748658.KB907312_gene1972	1.88e-114	347.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_768338_1	232721.Ajs_0143	4.21e-56	187.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4AAJP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_276874_1	981085.XP_010104005.1	2.8e-13	74.7	COG0625@1|root,KOG0868@2759|Eukaryota,37R8D@33090|Viridiplantae,3GD1G@35493|Streptophyta,4JGVV@91835|fabids	35493|Streptophyta	O	Glutathione S-transferase zeta	GSTZ1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0016034,GO:0016054,GO:0016853,GO:0016859,GO:0018958,GO:0019336,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042221,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1901999,GO:1902000	5.2.1.2	ko:K01800	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
k59_576421_1	391735.Veis_4881	1.59e-120	356.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,2VMZ8@28216|Betaproteobacteria,4AHWK@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_444552_1	395494.Galf_0597	1.42e-30	115.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,44VD2@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Transporter associated domain	corC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_444552_2	640081.Dsui_1196	2.14e-35	127.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2VSHV@28216|Betaproteobacteria,2KWFT@206389|Rhodocyclales	206389|Rhodocyclales	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
k59_21378_1	1354722.JQLS01000008_gene2267	3.92e-78	252.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_511156_1	243231.GSU1593	4.38e-150	451.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,43TFC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_534447_1	1122962.AULH01000010_gene1241	2.09e-36	125.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria,36YKG@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal L28 family	rpmB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_869317_1	713586.KB900536_gene2500	1.24e-24	108.0	COG4123@1|root,COG4123@2|Bacteria,1N6QK@1224|Proteobacteria,1SKXT@1236|Gammaproteobacteria,1X0IT@135613|Chromatiales	135613|Chromatiales	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
k59_186199_1	1122985.HMPREF1991_02404	1.35e-18	87.4	COG3214@1|root,COG3214@2|Bacteria,4NGF2@976|Bacteroidetes,2FP5R@200643|Bacteroidia	976|Bacteroidetes	S	COG NOG15865 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
k59_938169_1	412597.AEPN01000044_gene133	4.6e-05	46.2	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2PVK7@265|Paracoccus	28211|Alphaproteobacteria	S	Putative peptidoglycan binding domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_938169_3	652103.Rpdx1_4749	3.77e-162	469.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2TWCZ@28211|Alphaproteobacteria,3K6PJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Phosphate	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_578959_1	1120966.AUBU01000013_gene492	1.67e-12	70.5	COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,47NWH@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	pbpE	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_89326_1	290402.Cbei_4870	2.24e-52	177.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,36E9P@31979|Clostridiaceae	186801|Clostridia	G	Transketolase	tktB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_381411_2	404380.Gbem_2091	4.8e-13	70.1	COG5492@1|root,COG5492@2|Bacteria,1QYX0@1224|Proteobacteria	1224|Proteobacteria	N	Protein of unknown function (DUF3443)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF3443
k59_742348_1	1123073.KB899242_gene1686	4e-65	204.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1X3DJ@135614|Xanthomonadales	135614|Xanthomonadales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_677160_1	999541.bgla_1g05340	2.86e-105	314.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,1K06J@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_938184_1	1232410.KI421426_gene1458	2.14e-168	509.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_154170_1	404589.Anae109_0762	3.88e-95	301.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_121515_1	1097668.BYI23_C009420	1.37e-11	65.9	COG0834@1|root,COG0834@2|Bacteria,1MXEJ@1224|Proteobacteria,2WF9K@28216|Betaproteobacteria,1KGCU@119060|Burkholderiaceae	28216|Betaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_611023_1	1333998.M2A_1204	3.8e-91	272.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,4BPIB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_278116_1	265072.Mfla_1710	1.38e-103	310.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,2KM17@206350|Nitrosomonadales	206350|Nitrosomonadales	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_578980_1	1458275.AZ34_00685	1.1e-45	157.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,4A9J7@80864|Comamonadaceae	28216|Betaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_578980_2	999541.bgla_1g03090	1.17e-18	79.7	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2VQ0A@28216|Betaproteobacteria,1K6XR@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_381423_1	987059.RBXJA2T_06185	2.82e-110	335.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,1KJEI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_476420_1	3649.evm.model.supercontig_0.66	5.21e-11	58.5	2CYIR@1|root,2S4NT@2759|Eukaryota,37W8S@33090|Viridiplantae,3GKMR@35493|Streptophyta,3I1J5@3699|Brassicales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_186232_1	998674.ATTE01000001_gene1967	7.25e-53	179.0	COG1638@1|root,COG1638@2|Bacteria,1MUJY@1224|Proteobacteria,1S63M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_446881_1	479434.Sthe_2711	6.81e-19	84.7	COG1335@1|root,COG1335@2|Bacteria,2G922@200795|Chloroflexi,27YMA@189775|Thermomicrobia	189775|Thermomicrobia	Q	Isochorismatase family	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
k59_154188_1	278957.ABEA03000041_gene2224	6.93e-30	115.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_154188_2	713586.KB900536_gene2806	1e-08	59.3	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	acetolactate synthase	-	-	1.2.5.1,2.2.1.6,4.1.1.7	ko:K00156,ko:K01576,ko:K01652	ko00290,ko00620,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00620,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R03145,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC00860,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_154189_1	292415.Tbd_2176	5.84e-40	145.0	28Q1D@1|root,2ZCJS@2|Bacteria,1RF11@1224|Proteobacteria,2VQZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_791979_1	1121937.AUHJ01000001_gene648	7.24e-13	69.3	COG1028@1|root,COG1028@2|Bacteria,1Q737@1224|Proteobacteria,1S7IW@1236|Gammaproteobacteria,467DH@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_938212_1	1121935.AQXX01000139_gene3042	4.49e-45	162.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1XIX7@135619|Oceanospirillales	135619|Oceanospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_938212_2	930169.B5T_03745	2.05e-24	96.7	COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,1SD1Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_186244_1	1245475.ANAE01000075_gene2876	0.000187	44.3	COG0300@1|root,COG0300@2|Bacteria,2IIVW@201174|Actinobacteria,4EQ1E@85012|Streptosporangiales	201174|Actinobacteria	S	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_742375_1	543728.Vapar_2335	5.65e-84	255.0	COG1116@1|root,COG1116@2|Bacteria,1N7FP@1224|Proteobacteria,2VHGX@28216|Betaproteobacteria,4ACTB@80864|Comamonadaceae	28216|Betaproteobacteria	P	SMART AAA ATPase	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_742375_2	1265502.KB905951_gene842	3.85e-27	105.0	COG0600@1|root,COG0600@2|Bacteria,1MVD2@1224|Proteobacteria,2VI9N@28216|Betaproteobacteria,4AC9H@80864|Comamonadaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_710011_1	1429851.X548_18250	4.17e-75	232.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X38I@135614|Xanthomonadales	135614|Xanthomonadales	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_513674_1	76114.ebA2252	1.78e-97	315.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales	206389|Rhodocyclales	E	glutamate synthase	gls1	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_349702_1	640081.Dsui_3444	5.93e-73	230.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,2KU9M@206389|Rhodocyclales	206389|Rhodocyclales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroG	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_903320_1	1266925.JHVX01000006_gene2245	9.61e-82	256.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,372EM@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_938219_1	316275.VSAL_I1197	5.29e-74	235.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,1RNSQ@1236|Gammaproteobacteria,1XU5I@135623|Vibrionales	135623|Vibrionales	E	Belongs to the group II decarboxylase family	gadB	GO:0003674,GO:0003824,GO:0004351,GO:0006082,GO:0006520,GO:0006536,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
k59_579014_1	1123393.KB891316_gene1137	8.41e-74	225.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,2VRTS@28216|Betaproteobacteria,1KRXX@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Pfam:DUF989	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
k59_871745_1	999541.bgla_1g06580	5.79e-82	258.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,1K0Q5@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcD	-	1.1.2.4,1.1.3.15,1.1.5.12	ko:K00102,ko:K00104,ko:K03777	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475,R00704,R11591	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_840561_1	436308.Nmar_1389	4.38e-54	176.0	COG0543@1|root,arCOG02199@2157|Archaea,41SY5@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
k59_840561_2	436308.Nmar_1390	4.37e-40	140.0	COG0167@1|root,arCOG00603@2157|Archaea	2157|Archaea	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1	ko:K00226,ko:K00254,ko:K17723,ko:K17828	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01867,R01868,R01869,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_315367_1	398767.Glov_3666	7.82e-61	201.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_412257_2	864051.BurJ1DRAFT_4175	8.18e-48	170.0	COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria,1KN2G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_350599_1	1485544.JQKP01000004_gene482	9.63e-96	308.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,44V9P@713636|Nitrosomonadales	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_155101_1	794903.OPIT5_07675	2.14e-35	138.0	COG0421@1|root,COG0421@2|Bacteria,46Z5G@74201|Verrucomicrobia,3K91M@414999|Opitutae	414999|Opitutae	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_514612_1	1121405.dsmv_1647	2.09e-64	221.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,2MIAK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578,ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_412263_1	330214.NIDE2746	1.36e-37	134.0	COG0755@1|root,COG0755@2|Bacteria,3J14H@40117|Nitrospirae	40117|Nitrospirae	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_412263_2	1121405.dsmv_3366	9.19e-06	48.5	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2WM37@28221|Deltaproteobacteria,2MI98@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_872611_3	1382306.JNIM01000001_gene1472	8.89e-54	178.0	COG1321@1|root,COG1321@2|Bacteria,2G6N4@200795|Chloroflexi	200795|Chloroflexi	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
k59_382284_1	443598.AUFA01000004_gene5145	2.58e-33	127.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,3JX12@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_56468_1	1499967.BAYZ01000171_gene5541	1.14e-90	273.0	COG2084@1|root,COG2084@2|Bacteria,2NQRW@2323|unclassified Bacteria	2|Bacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	garR	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	iNRG857_1313.NRG857_15520	NAD_binding_11,NAD_binding_2
k59_155115_1	1088721.NSU_3401	1.51e-40	147.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria,2K0RB@204457|Sphingomonadales	204457|Sphingomonadales	C	alcohol dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_155116_1	1121447.JONL01000002_gene1993	3.03e-33	128.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2WKAK@28221|Deltaproteobacteria,2M8H5@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_579991_1	497964.CfE428DRAFT_1571	2.53e-132	389.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	tnp	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_841523_1	522306.CAP2UW1_0807	6.52e-89	300.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1KPY3@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_187144_1	1454004.AW11_03689	4.5e-104	311.0	2C8FN@1|root,2ZBER@2|Bacteria,1RK02@1224|Proteobacteria,2WG0U@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_24765_1	556268.OFAG_00321	1.97e-94	292.0	COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2W8DW@28216|Betaproteobacteria,477HA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Terminase RNAseH like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_3,Terminase_3C
k59_792371_1	251221.35210568	1.03e-105	314.0	COG0226@1|root,COG0226@2|Bacteria,1FZZ0@1117|Cyanobacteria	1117|Cyanobacteria	P	TIGRFAM phosphate binding protein	sphX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like,PBP_like_2
k59_316201_1	357808.RoseRS_0353	2.52e-149	441.0	COG4467@1|root,COG4467@2|Bacteria,2G8CX@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
k59_743353_1	279714.FuraDRAFT_3146	3.58e-196	573.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,2KPRX@206351|Neisseriales	206351|Neisseriales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_841529_1	1144342.PMI40_00312	1.19e-08	57.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,473P8@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_841529_2	1547437.LL06_14215	4.83e-22	87.8	2BZQB@1|root,32Y98@2|Bacteria,1R3P4@1224|Proteobacteria,2UFWD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_187149_1	497321.C664_18242	2.04e-86	262.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,2KUT2@206389|Rhodocyclales	206389|Rhodocyclales	K	RNA polymerase sigma	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_122378_1	640081.Dsui_2436	3.01e-124	380.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,2KV38@206389|Rhodocyclales	206389|Rhodocyclales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_382307_1	265072.Mfla_1714	1.26e-40	141.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ32@28216|Betaproteobacteria,2KKFM@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM response regulator receiver	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_382307_2	1003195.SCAT_3883	5.61e-05	47.4	COG4585@1|root,COG4585@2|Bacteria,2GMAB@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_904228_1	243231.GSU0994	9.85e-81	254.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,43DIW@68525|delta/epsilon subdivisions,2X8Q7@28221|Deltaproteobacteria,43S3E@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_841531_1	795666.MW7_1725	7.21e-65	214.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNBG@28216|Betaproteobacteria,1K297@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
k59_187154_2	1123229.AUBC01000014_gene2879	1.39e-36	125.0	COG2315@1|root,COG2315@2|Bacteria,1N108@1224|Proteobacteria,2UCUB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
k59_187154_3	435908.IDSA_01715	0.000586	42.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,2QFBS@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_611968_1	556268.OFAG_02055	2.66e-20	85.1	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2VRG9@28216|Betaproteobacteria,47429@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_611968_2	1385520.N802_03735	1.96e-64	217.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,4FEPE@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007,ko:K21787	ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00374,M00837,M00838	R00199,R11662,R11673	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_644349_1	391037.Sare_2200	8.48e-40	144.0	COG2040@1|root,COG2040@2|Bacteria,2GIWK@201174|Actinobacteria,4DIG6@85008|Micromonosporales	201174|Actinobacteria	E	Homocysteine S-methyltransferase	mmuM	-	2.1.1.10	ko:K00547,ko:K21169	ko00270,ko01059,ko01100,ko01110,ko01130,map00270,map01059,map01100,map01110,map01130	M00825	R00650	RC00003,RC00035	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
k59_939209_1	1380394.JADL01000011_gene3988	3.7e-13	70.1	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_939209_2	1411123.JQNH01000001_gene999	7.34e-53	175.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TRA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	coxM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_278679_1	330214.NIDE1331	1.73e-101	305.0	COG0201@1|root,COG0201@2|Bacteria,3J0C0@40117|Nitrospirae	40117|Nitrospirae	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_219723_1	335543.Sfum_2052	4.01e-18	83.6	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,42MHN@68525|delta/epsilon subdivisions,2WJU0@28221|Deltaproteobacteria,2MQNQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_56520_2	1163617.SCD_n01755	1.24e-35	131.0	COG0726@1|root,COG0726@2|Bacteria,1N8Q4@1224|Proteobacteria,2VKEP@28216|Betaproteobacteria	28216|Betaproteobacteria	G	polysaccharide deacetylase	arnD	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_971891_1	251221.35211676	8.04e-06	47.8	COG1429@1|root,COG1429@2|Bacteria	2|Bacteria	H	ligase activity, forming nitrogen-metal bonds	cobN	-	6.6.1.1,6.6.1.2	ko:K02230,ko:K03403	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877,R05227	RC01012,RC02000	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel,Glyco_hydro_63
k59_971891_2	1121405.dsmv_1693	1.82e-21	89.7	COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,42S3G@68525|delta/epsilon subdivisions,2WNET@28221|Deltaproteobacteria,2MMB5@213118|Desulfobacterales	28221|Deltaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_696980_1	153496.JNAB01000042_gene2399	5.08e-59	187.0	COG3415@1|root,COG3415@2|Bacteria,1NBHM@1224|Proteobacteria,2UAIZ@28211|Alphaproteobacteria,2JTA0@204441|Rhodospirillales	204441|Rhodospirillales	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,HTH_33
k59_696980_2	316056.RPC_4057	1.42e-45	151.0	COG3335@1|root,COG3335@2|Bacteria,1RDBN@1224|Proteobacteria,2VFA9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	transposable element conserved	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_859383_1	1366050.N234_29910	3.83e-75	242.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,1K1H9@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD4	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_108967_1	338963.Pcar_2557	6.34e-17	82.4	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,43UHA@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Bifunctional transglycosylase second domain	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_926326_1	1100721.ALKO01000017_gene1688	6.16e-83	259.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VK35@28216|Betaproteobacteria,4AA1P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	soxF	-	1.8.2.1,1.8.5.4	ko:K05301,ko:K17218	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00528,R10152	RC00168,RC03155	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2,TAT_signal
k59_926328_1	1116472.MGMO_15c00250	2.77e-32	124.0	COG1721@1|root,COG1721@2|Bacteria,1R69F@1224|Proteobacteria,1S8QT@1236|Gammaproteobacteria,1XEZS@135618|Methylococcales	135618|Methylococcales	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_501976_1	1485544.JQKP01000001_gene1215	7.1e-97	296.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,44VJQ@713636|Nitrosomonadales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	lplT	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_370498_1	706587.Desti_3897	1.76e-22	100.0	COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2MQDN@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	Stage II sporulation	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
k59_926341_1	177437.HRM2_12400	8.1e-33	124.0	COG0057@1|root,COG0057@2|Bacteria,1R8ZT@1224|Proteobacteria,42PY6@68525|delta/epsilon subdivisions,2WKEI@28221|Deltaproteobacteria,2MII4@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_926341_2	194439.CT1682	6.39e-16	79.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1FD96@1090|Chlorobi	1090|Chlorobi	H	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_990767_1	1123319.AUBE01000006_gene3191	3.27e-48	175.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria	201174|Actinobacteria	L	DNA helicase	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_338202_1	1169143.KB911038_gene6199	2.02e-26	103.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,2VXDV@28216|Betaproteobacteria,1K76Z@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG
k59_338202_2	640511.BC1002_5534	1.79e-26	102.0	2ERVI@1|root,32PBH@2|Bacteria,1PIRW@1224|Proteobacteria,2W7B6@28216|Betaproteobacteria,1KE93@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_304851_1	1095769.CAHF01000022_gene40	1.21e-47	160.0	COG5424@1|root,COG5424@2|Bacteria,1QVK0@1224|Proteobacteria	1224|Proteobacteria	H	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
k59_401560_1	1117647.M5M_08260	1.22e-71	242.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5K5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_958864_1	323848.Nmul_A2116	1.29e-96	294.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,37237@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	PFAM Major facilitator superfamily	lplT	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1017793_1	436308.Nmar_1319	6.41e-59	188.0	COG0863@1|root,arCOG00115@2157|Archaea,41SZP@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_1017793_2	436308.Nmar_1318	2.04e-19	82.4	COG1826@1|root,arCOG02694@2157|Archaea,41SRR@651137|Thaumarchaeota	651137|Thaumarchaeota	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_860250_1	930171.Asphe3_22180	1.31e-12	68.9	COG2514@1|root,COG2514@2|Bacteria,2GUZK@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_304856_1	608506.COB47_0049	9.74e-30	115.0	COG1682@1|root,COG1682@2|Bacteria,1V1J2@1239|Firmicutes,25B57@186801|Clostridia,42J3Y@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
k59_272341_1	395494.Galf_2800	8.1e-32	114.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,44VZT@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_272341_2	1485544.JQKP01000002_gene1499	6.45e-151	431.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,44VNI@713636|Nitrosomonadales	28216|Betaproteobacteria	D	TIGRFAM cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_860252_1	330214.NIDE3786	1.13e-55	194.0	COG0474@1|root,COG0474@2|Bacteria,3J0WH@40117|Nitrospirae	40117|Nitrospirae	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_860252_2	420324.KI912045_gene4583	0.000627	45.8	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,1JVY8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_828506_1	381764.Fnod_0983	3.45e-29	117.0	COG1180@1|root,COG1180@2|Bacteria,2GC8W@200918|Thermotogae	200918|Thermotogae	C	Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_631993_1	1283300.ATXB01000001_gene1274	5.59e-42	153.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_567158_1	338966.Ppro_2553	1.89e-25	103.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,43SK7@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_272345_1	926550.CLDAP_26100	3.05e-61	193.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,HTH_33
k59_892489_1	396588.Tgr7_0763	9.25e-55	189.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_338233_1	1125863.JAFN01000001_gene775	1.87e-121	357.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_730441_1	6500.XP_005091913.1	5.47e-30	122.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria	33208|Metazoa	J	protein phosphatase regulator activity	-	-	2.3.1.15,2.4.2.29	ko:K13506,ko:K15407	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R03789,R09380,R10209	RC00004,RC00039,RC00041,RC00063	ko00000,ko00001,ko00002,ko01000,ko01004,ko03016	-	-	-	Exo_endo_phos_2,RVT_1
k59_207567_1	365046.Rta_22800	2.48e-116	359.0	COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2VIUH@28216|Betaproteobacteria,4AF6G@80864|Comamonadaceae	28216|Betaproteobacteria	M	membrane-associated Zn-dependent proteases 1	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_207568_1	1304883.KI912532_gene1360	2.05e-71	221.0	COG3108@1|root,COG3108@2|Bacteria	2|Bacteria	S	Peptidase M15	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	Peptidase_M15_3
k59_502023_1	412597.AEPN01000023_gene760	7.76e-05	44.3	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,2PVYR@265|Paracoccus	28211|Alphaproteobacteria	IQ	KR domain	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_502023_2	1276756.AUEX01000004_gene2353	4.74e-85	266.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_502023_3	266835.14027139	7.35e-11	64.3	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,43JTB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_1017810_1	1121405.dsmv_3099	9.51e-58	186.0	COG2974@1|root,COG2974@2|Bacteria,1N4GC@1224|Proteobacteria,42RPT@68525|delta/epsilon subdivisions,2WQUM@28221|Deltaproteobacteria,2MJSD@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Putative exonuclease, RdgC	-	-	-	-	-	-	-	-	-	-	-	-	RdgC
k59_12215_1	1005048.CFU_0471	8.07e-11	62.0	COG5285@1|root,COG5285@2|Bacteria,1RC3C@1224|Proteobacteria,2VQJ9@28216|Betaproteobacteria,473WG@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	1.14.11.18	ko:K00477	ko04146,map04146	-	-	-	ko00000,ko00001,ko01000	-	-	-	PhyH
k59_12215_2	1122134.KB893651_gene1827	1.78e-26	105.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1S6B5@1236|Gammaproteobacteria,1XK3Q@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_926389_1	330214.NIDE0782	1.45e-49	164.0	COG1825@1|root,COG1825@2|Bacteria,3J0NK@40117|Nitrospirae	40117|Nitrospirae	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_926389_2	330214.NIDE0781	7.53e-127	367.0	COG0462@1|root,COG0462@2|Bacteria,3J0D0@40117|Nitrospirae	40117|Nitrospirae	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_567184_1	330214.NIDE1201	1.26e-90	278.0	COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.6.1.1,1.8.1.4	ko:K00322,ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map00760,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00112,R00209,R01221,R01698,R03815,R07618,R08549	RC00001,RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_142625_1	180332.JTGN01000011_gene464	7.16e-39	144.0	COG1879@1|root,COG1879@2|Bacteria,1VRNE@1239|Firmicutes,24Z7U@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
k59_370561_1	47763.JNZA01000029_gene3606	2.74e-46	167.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_370561_2	1540221.JQNI01000002_gene1179	3.93e-07	50.8	COG1173@1|root,COG1173@2|Bacteria,1WIH4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_990808_1	926554.KI912640_gene1276	6.79e-92	283.0	COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_12242_1	637905.SVI_0107	2.15e-34	130.0	COG1887@1|root,COG1887@2|Bacteria,1R659@1224|Proteobacteria,1RY11@1236|Gammaproteobacteria,2QB3D@267890|Shewanellaceae	1236|Gammaproteobacteria	M	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyphos_transf
k59_828558_1	237609.PSAKL28_31720	7.47e-171	500.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,1RZMQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_435839_1	1122222.AXWR01000006_gene2794	2.26e-08	57.0	COG2366@1|root,COG2366@2|Bacteria,1WJ3J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	peptidase S45, penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_370581_1	93220.LV28_07725	1.44e-05	47.4	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1K0VI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Peptidase M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_370581_2	583345.Mmol_2232	2.42e-46	154.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2VR7B@28216|Betaproteobacteria,2KMT6@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_142647_1	94624.Bpet1982	1.5e-56	190.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2VI11@28216|Betaproteobacteria,3T2Y8@506|Alcaligenaceae	28216|Betaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	ectB	-	2.6.1.76	ko:K00836	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	M00033	R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_142647_2	986075.CathTA2_0629	6.08e-08	51.6	COG1917@1|root,COG1917@2|Bacteria,1V719@1239|Firmicutes,4HIPQ@91061|Bacilli	91061|Bacilli	S	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant	ectC	-	4.2.1.108	ko:K06720	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06979	RC01729	ko00000,ko00001,ko00002,ko01000	-	-	-	Ectoine_synth
k59_828567_1	1267005.KB911256_gene1593	6.06e-142	411.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TUTX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Multi-copper	copA	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_207613_2	1353529.M899_0362	4.68e-17	78.6	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,42S73@68525|delta/epsilon subdivisions,2WNPE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_338289_1	933262.AXAM01000017_gene3141	2.11e-47	162.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,2MI1V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_338289_2	933262.AXAM01000017_gene3142	1.49e-11	63.5	COG1035@1|root,COG4656@1|root,COG1035@2|Bacteria,COG4656@2|Bacteria,1NQN7@1224|Proteobacteria,42MGI@68525|delta/epsilon subdivisions,2WKNC@28221|Deltaproteobacteria,2MIJN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrD	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_17,Fer4_8,FlpD,FrhB_FdhB_C
k59_599685_1	1499967.BAYZ01000009_gene5392	3.29e-108	327.0	COG2719@1|root,COG2719@2|Bacteria	2|Bacteria	S	cellular response to DNA damage stimulus	spoVR	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
k59_370589_2	314285.KT71_13420	4.29e-36	134.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RY8P@1236|Gammaproteobacteria,1J91W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Amino acid permease	frlA	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039	-	ko:K03294,ko:K19540	-	-	-	-	ko00000,ko02000	2.A.3.2,2.A.3.8.17	-	iAF1260.b3370,iB21_1397.B21_03173,iBWG_1329.BWG_3062,iEC042_1314.EC042_3632,iEC55989_1330.EC55989_3776,iECBD_1354.ECBD_0378,iECB_1328.ECB_03221,iECDH10B_1368.ECDH10B_3546,iECDH1ME8569_1439.ECDH1ME8569_3250,iECD_1391.ECD_03221,iECIAI1_1343.ECIAI1_3509,iECO111_1330.ECO111_4180,iECO26_1355.ECO26_4459,iETEC_1333.ETEC_3621,iEcDH1_1363.EcDH1_0342,iJO1366.b3370,iSSON_1240.SSON_3502,iUMNK88_1353.UMNK88_4136,iY75_1357.Y75_RS20365	AA_permease_2
k59_502074_1	879212.DespoDRAFT_00649	3.32e-94	286.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42NHU@68525|delta/epsilon subdivisions,2WIZ1@28221|Deltaproteobacteria,2MIQ6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.99.32	ko:K16173	ko00362,ko01120,map00362,map01120	-	R05579	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_207614_1	331678.Cphamn1_1145	2.76e-35	138.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	int	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_466792_1	1118153.MOY_08042	5.38e-43	155.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1XIU0@135619|Oceanospirillales	135619|Oceanospirillales	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_401631_1	1123060.JONP01000048_gene2417	1.13e-46	163.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JSUV@204441|Rhodospirillales	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_958958_1	522306.CAP2UW1_0537	1.61e-170	489.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,1KPMZ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Translation, ribosomal structure and biogenesis	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_958958_2	748247.AZKH_0533	2.14e-28	113.0	COG0657@1|root,COG0657@2|Bacteria,1MV89@1224|Proteobacteria,2VJJC@28216|Betaproteobacteria,2M03F@206389|Rhodocyclales	206389|Rhodocyclales	I	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
k59_401632_2	94624.Bpet4537	8.38e-74	238.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,3T1UQ@506|Alcaligenaceae	28216|Betaproteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	-	1.8.1.2,1.8.7.1	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858,R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_698088_1	882.DVU_2824	7.92e-111	342.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2M9FS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_599701_1	398767.Glov_2079	1.61e-37	144.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,43TR2@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM Carbamoyl-phosphate synthase L chain ATP-binding	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_207625_1	1485544.JQKP01000013_gene1849	1.47e-40	138.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VRCR@28216|Betaproteobacteria,44WEK@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Bacterial protein of unknown function (DUF899)	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_860338_1	1288494.EBAPG3_22310	8.82e-08	56.6	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,372E9@32003|Nitrosomonadales	28216|Betaproteobacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_860338_2	944435.AXAJ01000019_gene5233	7.17e-54	191.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1K1Q0@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	abc transporter, permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_760612_1	864051.BurJ1DRAFT_1335	5.45e-69	214.0	COG4539@1|root,COG4539@2|Bacteria,1RHUB@1224|Proteobacteria,2VTDF@28216|Betaproteobacteria,1KM7Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
k59_926463_1	2850.Phatr46068	2.7e-47	161.0	2BBKE@1|root,2S0Y6@2759|Eukaryota,2XEU5@2836|Bacillariophyta	2836|Bacillariophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_935484_2	1304883.KI912532_gene1716	5.19e-25	101.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,2KU9M@206389|Rhodocyclales	206389|Rhodocyclales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroG	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_707229_1	395961.Cyan7425_3755	1.2e-32	130.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1G17N@1117|Cyanobacteria,3KFXD@43988|Cyanothece	1117|Cyanobacteria	T	Adenylate guanylate cyclase with Chase sensor	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_837768_1	1266925.JHVX01000001_gene2489	1.63e-68	211.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,3731F@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_312977_1	395495.Lcho_2150	4.91e-38	138.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria,1KK3S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_312977_2	338969.Rfer_2185	9.87e-133	383.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,2VKQX@28216|Betaproteobacteria,4AH00@80864|Comamonadaceae	28216|Betaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	porB	-	1.2.1.58,1.2.7.1	ko:K00170,ko:K18356	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_11,Fer4_6,TPP_enzyme_C
k59_118873_1	349521.HCH_01486	5.96e-52	181.0	COG0457@1|root,COG0457@2|Bacteria,1QZ9R@1224|Proteobacteria,1S0PE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_409094_1	395493.BegalDRAFT_2911	3.18e-94	300.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,45ZWT@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_347075_1	1454004.AW11_03350	1.1e-69	233.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,1KPP9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_768203_1	1385515.N791_02970	5.13e-12	67.8	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1X3VR@135614|Xanthomonadales	135614|Xanthomonadales	O	Membrane-bound serine protease (ClpP class)	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_768203_2	631454.N177_3428	5.88e-49	164.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,1JPBF@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_379019_1	631362.Thi970DRAFT_04980	1.26e-72	224.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1WWMS@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_183883_1	395495.Lcho_0775	6.78e-70	221.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2VICA@28216|Betaproteobacteria,1KPA2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Phage integrase SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_900815_1	47839.CCAU010000017_gene3944	1.35e-14	78.6	COG2041@1|root,COG4117@1|root,COG2041@2|Bacteria,COG4117@2|Bacteria,2GIZH@201174|Actinobacteria,232EE@1762|Mycobacteriaceae	201174|Actinobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
k59_608455_1	582744.Msip34_1248	8.86e-43	160.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KKF5@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_409103_1	1192034.CAP_2917	9.53e-25	96.7	COG0346@1|root,COG0346@2|Bacteria,1QAIR@1224|Proteobacteria,434GN@68525|delta/epsilon subdivisions,2WYU0@28221|Deltaproteobacteria,2Z0M3@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_409103_2	290397.Adeh_2253	1.54e-22	98.6	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales	28221|Deltaproteobacteria	K	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat
k59_1022082_1	234267.Acid_6581	7.03e-93	283.0	COG0183@1|root,COG0183@2|Bacteria,3Y7RP@57723|Acidobacteria	57723|Acidobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
k59_768219_2	1163617.SCD_n02704	1.66e-60	199.0	COG1249@1|root,COG1249@2|Bacteria,1RB5F@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	lpdA_2	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_313000_2	1488328.JMCL01000018_gene551	1.64e-20	94.7	COG2206@1|root,COG2206@2|Bacteria,1MV37@1224|Proteobacteria,1RM9C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0840 Methyl-accepting chemotaxis protein	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,dCache_1
k59_869174_1	977880.RALTA_A1396	1.05e-81	251.0	COG0280@1|root,COG0280@2|Bacteria,1QTXP@1224|Proteobacteria,2VJ4B@28216|Betaproteobacteria,1K2V8@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM phosphate acetyl butaryl transferase	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
k59_869174_2	388051.AUFE01000001_gene1907	2.32e-30	118.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_999563_1	1282876.BAOK01000001_gene2557	9.2e-86	266.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,4BQUU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	OsmC-like protein	MA20_16590	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
k59_1022088_1	349161.Dred_2764	4.71e-19	85.1	COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,263EU@186807|Peptococcaceae	186801|Clostridia	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_86691_1	880072.Desac_0419	8.55e-96	305.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MQZP@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_935528_1	930169.B5T_03700	6.27e-75	241.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1XHV2@135619|Oceanospirillales	135619|Oceanospirillales	E	acetolactate synthase	ilvB-1	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_151576_1	267608.RSp1362	4.58e-107	324.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2VPGV@28216|Betaproteobacteria,1K2CQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_511024_1	1366050.N234_13000	5.65e-81	258.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,1K005@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	ilvG	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_608480_1	397278.JOJN01000005_gene774	4.84e-48	166.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k59_608480_2	756499.Desde_3267	3.48e-07	56.6	COG2267@1|root,COG2267@2|Bacteria,1V4GY@1239|Firmicutes,25EJZ@186801|Clostridia,261ST@186807|Peptococcaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_534387_1	335283.Neut_2511	1.73e-88	277.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria,37263@32003|Nitrosomonadales	28216|Betaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_739731_1	330214.NIDE0606	1.36e-34	124.0	COG0839@1|root,COG0839@2|Bacteria,3J0RP@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_674500_1	1173028.ANKO01000199_gene3576	1.1e-49	178.0	COG0642@1|root,COG2199@1|root,COG2202@1|root,COG3452@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3452@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,1FZWU@1117|Cyanobacteria,1H8MG@1150|Oscillatoriales	1117|Cyanobacteria	T	GGDEF domain'	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_768244_1	864051.BurJ1DRAFT_2867	1.82e-83	273.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ1H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	nolG	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_837833_1	1177179.A11A3_08170	1.25e-93	283.0	COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,1XHZG@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
k59_379066_1	272134.KB731324_gene890	8.18e-17	85.9	COG2931@1|root,COG3210@1|root,COG4932@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1G0DX@1117|Cyanobacteria,1H9Z9@1150|Oscillatoriales	1117|Cyanobacteria	QU	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,Calx-beta,DUF11,DUF4347,HemolysinCabind,Laminin_G_3,VCBS
k59_608499_1	1577887.JSYG01000020_gene1542	3.68e-63	206.0	COG2706@1|root,COG2706@2|Bacteria,1MWGS@1224|Proteobacteria,1RNX2@1236|Gammaproteobacteria,2JCB2@204037|Dickeya	1236|Gammaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
k59_674517_1	1131553.JIBI01000071_gene2158	2.54e-99	304.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,3720Q@32003|Nitrosomonadales	28216|Betaproteobacteria	C	TrkA-N domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_837842_1	1123277.KB893217_gene4649	0.000711	42.7	292UM@1|root,2ZQC9@2|Bacteria,4NTGF@976|Bacteroidetes,47V3C@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_900874_1	395495.Lcho_3623	4.46e-52	182.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KMNN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22,PMT_2
k59_1022103_1	469610.HMPREF0189_02121	2.93e-45	160.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VM4Z@28216|Betaproteobacteria,1KPAK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Peptidase dimerisation domain	yxeP_2	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_313048_1	420662.Mpe_A3162	1.03e-60	201.0	COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,2VKV2@28216|Betaproteobacteria,1KKRF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_409152_1	713587.THITH_04060	2.6e-35	128.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,1WWCR@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_347157_1	398580.Dshi_3398	3.52e-83	249.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_183947_1	436308.Nmar_1790	2.94e-134	392.0	COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_216335_2	3847.GLYMA0405S00215.1	1.35e-13	71.6	COG0199@1|root,KOG1741@2759|Eukaryota,3896F@33090|Viridiplantae,3GY3H@35493|Streptophyta,4JWAW@91835|fabids	35493|Streptophyta	J	Ribosomal protein S14p/S29e	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S14
k59_739782_1	666684.AfiDRAFT_2921	1.88e-21	90.9	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,2TU5T@28211|Alphaproteobacteria,3JXPE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate	tam	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_245916_1	1041930.Mtc_0758	5.34e-59	202.0	COG0340@1|root,COG0439@1|root,arCOG01590@2157|Archaea,arCOG01940@2157|Archaea,2Y8CM@28890|Euryarchaeota,2N91K@224756|Methanomicrobia	224756|Methanomicrobia	I	Carbamoyl-phosphate synthetase large chain domain protein	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_86754_2	1499686.BN1079_02373	1.33e-18	86.3	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	coaT	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_245922_1	1123487.KB892834_gene2802	7.65e-111	327.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VJC7@28216|Betaproteobacteria,2KUUU@206389|Rhodocyclales	206389|Rhodocyclales	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_534413_1	929556.Solca_2367	1.22e-08	66.2	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,HYR,HemolysinCabind,IgGFc_binding
k59_837881_1	1123060.JONP01000005_gene5760	6.44e-39	140.0	COG2267@1|root,COG2267@2|Bacteria,1P7JV@1224|Proteobacteria,2TUWY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	MA20_38155	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Polyketide_cyc2
k59_151635_1	292415.Tbd_1714	7.36e-68	208.0	COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,2VT6I@28216|Betaproteobacteria,1KSD1@119069|Hydrogenophilales	119069|Hydrogenophilales	K	Ferric uptake regulator family	-	-	-	ko:K09826	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_151635_2	795666.MW7_2512	5.58e-100	299.0	COG1028@1|root,COG1028@2|Bacteria,1NBB6@1224|Proteobacteria,2VNXU@28216|Betaproteobacteria,1K116@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_968227_1	1297863.APJF01000005_gene1851	1.3e-70	223.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2TU5K@28211|Alphaproteobacteria,3JUDU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
k59_768294_1	404589.Anae109_1472	1.57e-107	326.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YZR7@29|Myxococcales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_790923_1	675812.VHA_000202	5.19e-67	212.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1XTQ1@135623|Vibrionales	135623|Vibrionales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_739810_1	864051.BurJ1DRAFT_0570	2.82e-38	137.0	COG0767@1|root,COG0767@2|Bacteria,1NSBS@1224|Proteobacteria,2VKK9@28216|Betaproteobacteria,1KN8P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_379123_1	1144275.COCOR_01450	1.11e-180	525.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria	1224|Proteobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_151648_1	647113.Metok_1480	5.32e-68	217.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23Q7Q@183939|Methanococci	183939|Methanococci	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
k59_512438_1	1125863.JAFN01000001_gene2739	2.87e-75	237.0	COG0426@1|root,COG0426@2|Bacteria,1NDXY@1224|Proteobacteria,42N11@68525|delta/epsilon subdivisions,2WJ8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	flavodoxin nitric oxide synthase	roo	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
k59_217613_1	436308.Nmar_0686	2.56e-30	119.0	COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_217613_2	436308.Nmar_0685	1.72e-121	351.0	COG0561@1|root,arCOG01213@2157|Archaea,41SIV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Phosphoglycolate phosphatase	-	-	3.1.3.18	ko:K22223	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
k59_22608_1	330214.NIDE1365	7.44e-77	231.0	COG1513@1|root,COG1513@2|Bacteria	2|Bacteria	P	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide	cynS	-	4.2.1.104	ko:K01725	ko00910,map00910	-	R03546,R10079	RC00952	ko00000,ko00001,ko01000	-	-	-	Cyanate_lyase
k59_936972_1	1123367.C666_02645	1.99e-72	241.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,2KUJG@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_512443_1	882378.RBRH_02095	1.24e-90	284.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1K0F2@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_870562_1	1381123.AYOD01000002_gene643	4.21e-69	227.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,43IGJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_152988_1	404589.Anae109_3749	1.42e-41	157.0	28I8B@1|root,2Z8B5@2|Bacteria,1R013@1224|Proteobacteria,42ZRI@68525|delta/epsilon subdivisions,2WUWF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,Cytochrome_cB
k59_185135_1	313612.L8106_03599	4.15e-41	153.0	COG1653@1|root,COG1653@2|Bacteria,1G04B@1117|Cyanobacteria,1H8YD@1150|Oscillatoriales	1117|Cyanobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
k59_969646_1	643562.Daes_2562	3.01e-98	305.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria,2MBEI@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_356915_1	1349767.GJA_562	8.32e-24	103.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,474YU@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	DUF3369,HD,HD_5,Response_reg
k59_945572_2	640513.Entas_1587	1.95e-35	133.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,3X1F2@547|Enterobacter	1236|Gammaproteobacteria	M	Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)	lpxL	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iSF_1195.SF1061,iS_1188.S1138,iYL1228.KPN_01068	Lip_A_acyltrans
k59_777034_1	1238182.C882_1637	2.26e-34	130.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2TSA1@28211|Alphaproteobacteria,2JR3Q@204441|Rhodospirillales	204441|Rhodospirillales	Q	imidazolonepropionase activity	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_848051_1	428125.CLOLEP_03091	1.1e-42	146.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,3WGN9@541000|Ruminococcaceae	186801|Clostridia	C	thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_848051_2	404589.Anae109_4114	8.66e-06	49.7	COG0674@1|root,COG0674@2|Bacteria,1MWCI@1224|Proteobacteria,42NJY@68525|delta/epsilon subdivisions,2WIW3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	vorA	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1307	PFOR_II,POR_N
k59_282042_1	686340.Metal_1494	7.14e-104	322.0	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RRZM@1236|Gammaproteobacteria,1XH02@135618|Methylococcales	135618|Methylococcales	C	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,SCO1-SenC
k59_777038_1	395961.Cyan7425_3884	2.24e-17	86.7	COG0661@1|root,COG0661@2|Bacteria,1G1KC@1117|Cyanobacteria,3KH08@43988|Cyanothece	1117|Cyanobacteria	S	PFAM ABC-1 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_684675_1	631454.N177_0823	5.76e-86	268.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,1JPPV@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_30973_1	880071.Fleli_3714	2.79e-36	132.0	COG1028@1|root,COG1028@2|Bacteria,4NGZI@976|Bacteroidetes,47M6H@768503|Cytophagia	976|Bacteroidetes	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_30973_2	1000565.METUNv1_00896	3.8e-42	142.0	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,2VQT7@28216|Betaproteobacteria,2KWDI@206389|Rhodocyclales	206389|Rhodocyclales	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_1008912_1	648757.Rvan_3455	9.16e-101	305.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,3N69P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_848064_1	903818.KI912268_gene1284	9.07e-66	219.0	COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_618129_1	768671.ThimaDRAFT_1435	2.64e-114	332.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1WWPE@135613|Chromatiales	135613|Chromatiales	G	HAD-superfamily hydrolase, subfamily IA, variant 3	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_521151_1	933262.AXAM01000022_gene3227	1.4e-43	156.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42N2H@68525|delta/epsilon subdivisions,2WMIR@28221|Deltaproteobacteria,2MIIF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_521151_2	177437.HRM2_35680	4.76e-63	201.0	COG1309@1|root,COG1309@2|Bacteria,1MV2V@1224|Proteobacteria,42NW6@68525|delta/epsilon subdivisions,2WPIG@28221|Deltaproteobacteria,2MI81@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Tetracycline transcriptional regulator YsiA domain protein	-	-	-	ko:K13770	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
k59_482599_1	1163617.SCD_n01394	1.13e-117	349.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	degQ	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_225703_1	1122603.ATVI01000009_gene2515	1.21e-27	115.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1X4RY@135614|Xanthomonadales	135614|Xanthomonadales	NU	secretion system protein	xcsD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_978395_1	1461580.CCAS010000060_gene3848	0.00035	46.6	COG3409@1|root,COG3409@2|Bacteria,1TPV1@1239|Firmicutes,4HI6Q@91061|Bacilli	91061|Bacilli	M	Domain of unknown function (DUF1906)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1906,PG_binding_1
k59_978395_2	1399147.P618_201153	1.52e-11	69.3	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,47F65@766|Rickettsiales	766|Rickettsiales	M	COG0739 Membrane proteins related to metalloendopeptidases	nlpD2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_618140_1	1449351.RISW2_12005	3.55e-07	55.8	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2TQVT@28211|Alphaproteobacteria,4KMDM@93682|Roseivivax	28211|Alphaproteobacteria	G	C4-dicarboxylate ABC transporter	dctP_1	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_978399_1	1288494.EBAPG3_9990	2.58e-60	194.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,372VZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Integrase, catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve_3
k59_482610_1	697281.Mahau_2710	1.08e-47	165.0	COG2855@1|root,COG2855@2|Bacteria,1TQYA@1239|Firmicutes,247X6@186801|Clostridia,42GM3@68295|Thermoanaerobacterales	186801|Clostridia	S	Conserved hypothetical protein 698	yeiH	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_62564_1	76114.ebA7001	2.8e-108	341.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,2KYAT@206389|Rhodocyclales	206389|Rhodocyclales	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_453821_1	126957.SMAR002430-PA	2.14e-28	112.0	COG0127@1|root,KOG3222@2759|Eukaryota,38DZ3@33154|Opisthokonta,3BE5N@33208|Metazoa,3CSAU@33213|Bilateria,41YUF@6656|Arthropoda	33208|Metazoa	F	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions	ITPA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006193,GO:0006195,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009150,GO:0009154,GO:0009166,GO:0009199,GO:0009203,GO:0009205,GO:0009207,GO:0009259,GO:0009261,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046041,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0051276,GO:0055086,GO:0071704,GO:0071840,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	-	ko:K01519	ko00230,ko00983,ko01100,map00230,map00983,map01100	-	R00426,R00720,R01855,R02100,R02720,R03531,R08243	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
k59_482617_1	691883.XP_009497011.1	2.08e-31	125.0	2BCE0@1|root,2S0ZX@2759|Eukaryota,3A2CB@33154|Opisthokonta	33154|Opisthokonta	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_618149_1	1231391.AMZF01000092_gene53	1.42e-28	118.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2VM0Y@28216|Betaproteobacteria,3T3NB@506|Alcaligenaceae	28216|Betaproteobacteria	J	Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_225719_1	977880.RALTA_A0133	3.55e-41	145.0	COG0491@1|root,COG0491@2|Bacteria,1NCIF@1224|Proteobacteria,2VJVR@28216|Betaproteobacteria,1K41C@119060|Burkholderiaceae	28216|Betaproteobacteria	S	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_225719_2	864051.BurJ1DRAFT_1531	2.77e-15	72.4	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2W2SU@28216|Betaproteobacteria,1KNNH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_1027186_1	1136417.AZWE01000029_gene226	6e-14	75.1	COG0543@1|root,COG1017@1|root,COG0543@2|Bacteria,COG1017@2|Bacteria,2GKXT@201174|Actinobacteria,4D9VT@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the globin family	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Globin,NAD_binding_1
k59_878774_1	935548.KI912159_gene2658	3.6e-22	97.1	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,2TRYC@28211|Alphaproteobacteria,43HE9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_848106_2	1121451.DESAM_22149	9.27e-43	147.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKYI@28221|Deltaproteobacteria,2MA7Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
k59_453843_1	420324.KI912003_gene8579	7.96e-22	97.8	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system periplasmic component	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_254509_1	1562701.BBOF01000068_gene2202	9.42e-79	253.0	COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,2WH05@28216|Betaproteobacteria,1K26F@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Pfam Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
k59_417838_1	933262.AXAM01000010_gene1349	5.7e-38	146.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_96794_1	1121028.ARQE01000003_gene786	1.12e-11	65.9	COG0824@1|root,COG0824@2|Bacteria,1PF22@1224|Proteobacteria,2VBGV@28211|Alphaproteobacteria,2PK86@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
k59_978430_1	1121943.KB899989_gene3259	2.41e-19	88.6	COG0625@1|root,COG0625@2|Bacteria,1NA52@1224|Proteobacteria,1SJHZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_N_3
k59_321915_1	765912.Thimo_0707	8.7e-91	286.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales	135613|Chromatiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_521201_2	1411123.JQNH01000001_gene207	7.16e-05	45.4	2EB0P@1|root,3351I@2|Bacteria,1NAEB@1224|Proteobacteria,2UG0E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_848120_1	717605.Theco_3543	1.2e-44	160.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,1TT8V@1239|Firmicutes,4HCE5@91061|Bacilli,26TZA@186822|Paenibacillaceae	91061|Bacilli	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_29,rve
k59_750816_1	543728.Vapar_2221	1.53e-41	146.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VN5P@28216|Betaproteobacteria,4AGSI@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_750816_2	543728.Vapar_2222	9.77e-32	117.0	2E6D9@1|root,3310W@2|Bacteria,1N9Y9@1224|Proteobacteria,2VWRF@28216|Betaproteobacteria,4AHXJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_31901_1	1121935.AQXX01000109_gene480	3.05e-93	300.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_946451_1	375286.mma_0277	1.09e-17	83.6	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,473CU@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	ABC transporter transmembrane region	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_946451_2	196367.JNFG01000044_gene1649	1.46e-14	72.8	COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VJQ5@28216|Betaproteobacteria,1K1H5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_651209_1	595460.RRSWK_03772	1.13e-79	262.0	COG0515@1|root,COG0515@2|Bacteria,2IXG3@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	HDOD,Pkinase,dCache_1
k59_31910_1	351016.RAZWK3B_14688	7.84e-112	326.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,2P546@2433|Roseobacter	28211|Alphaproteobacteria	L	COG3328 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_979264_1	323848.Nmul_A2509	1.03e-99	304.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,372GX@32003|Nitrosomonadales	28216|Betaproteobacteria	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_539862_1	266117.Rxyl_2767	1.4e-21	95.9	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4CQ0A@84995|Rubrobacteria	84995|Rubrobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_129585_1	292415.Tbd_2319	5.23e-152	466.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtC	-	-	ko:K03296,ko:K07788,ko:K07789,ko:K21133	ko02020,map02020	M00648,M00822	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2,2.A.6.2.35	-	-	ACR_tran
k59_97669_1	519989.ECTPHS_04039	2.76e-47	153.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1WYVV@135613|Chromatiales	135613|Chromatiales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_587457_2	378806.STAUR_0634	8.12e-29	109.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,434GM@68525|delta/epsilon subdivisions,2WYTZ@28221|Deltaproteobacteria,2Z0M0@29|Myxococcales	28221|Deltaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
k59_1009730_1	1266925.JHVX01000006_gene2240	3.58e-145	422.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,372X1@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	Sugar (and other) transporter	yajR	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1009730_2	1218084.BBJK01000019_gene2010	1.03e-11	63.9	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,1K1J9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_979282_1	1131553.JIBI01000006_gene1110	2.97e-14	69.7	COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,37363@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Phosphoglycerate mutase family	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_357895_1	75379.Tint_0589	1.25e-104	315.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,1KKIQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	TRAP C4-dicarboxylate transport system permease DctM subunit	dctM	-	-	ko:K11690,ko:K21393	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_282498_1	762376.AXYL_03196	6.69e-143	421.0	COG4623@1|root,COG4623@2|Bacteria	2|Bacteria	M	carbon-oxygen lyase activity, acting on polysaccharides	VP0557	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SLT
k59_129602_1	365046.Rta_15900	2.17e-75	236.0	COG1995@1|root,COG1995@2|Bacteria,1MXGJ@1224|Proteobacteria,2VISV@28216|Betaproteobacteria,4ABVP@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the PdxA family	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_63390_1	1122929.KB908220_gene2737	3.03e-122	363.0	COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,2TST0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
k59_1009741_1	945713.IALB_0288	3.39e-31	124.0	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	1.1.1.3,1.4.1.2,2.7.7.19,2.7.7.42,2.7.7.59,2.7.7.72,2.7.7.89	ko:K00003,ko:K00970,ko:K00974,ko:K00982,ko:K00990,ko:K06950,ko:K15371	ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,ko03013,ko03018,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020,map03013,map03018	M00017,M00018	R00243,R01773,R01775,R09382,R09383,R09384,R09386	RC00006,RC00078,RC00087,RC02799	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2,PolyA_pol,PolyA_pol_RNAbd
k59_136906_3	1304883.KI912532_gene3136	2.08e-05	43.1	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2VU1B@28216|Betaproteobacteria,2KWVC@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_527072_1	1121035.AUCH01000008_gene1072	2.36e-73	231.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,2KVG7@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_38883_1	497964.CfE428DRAFT_1536	9.88e-110	331.0	COG0160@1|root,COG0160@2|Bacteria,46UEH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k59_233777_1	177437.HRM2_41730	6.96e-65	216.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,2MISZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Cytochrome c, bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrome_C554,Cytochrome_cB
k59_136916_1	1217718.ALOU01000049_gene4396	2.95e-20	89.7	COG1802@1|root,COG1802@2|Bacteria,1R96W@1224|Proteobacteria,2VIQU@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_953026_1	1109445.AGSX01000127_gene2416	2.25e-44	151.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,1Z159@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	blh	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
k59_593921_1	179408.Osc7112_5586	3.35e-49	177.0	COG0845@1|root,COG0845@2|Bacteria,1G49W@1117|Cyanobacteria,1HH98@1150|Oscillatoriales	1117|Cyanobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_6319_2	1288298.rosmuc_02668	6.11e-62	196.0	2BZ0R@1|root,2Z7U0@2|Bacteria,1MX37@1224|Proteobacteria,2TSBD@28211|Alphaproteobacteria,46QCF@74030|Roseovarius	28211|Alphaproteobacteria	S	Nitrile hydratase, alpha chain	nthA	-	4.2.1.84	ko:K01721,ko:K20807	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R02828,R04020,R05379,R05596,R07780,R07854	RC00483,RC00792,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_alpha
k59_233785_2	194439.CT0332	4.81e-15	70.1	COG2336@1|root,COG2336@2|Bacteria	2|Bacteria	T	PFAM SpoVT AbrB	-	-	-	ko:K07172,ko:K18842	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
k59_462195_1	666684.AfiDRAFT_1063	4.58e-34	125.0	COG2128@1|root,COG2128@2|Bacteria,1N56H@1224|Proteobacteria,2UABU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_593938_1	748247.AZKH_3053	1.21e-87	273.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,2KUBM@206389|Rhodocyclales	206389|Rhodocyclales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_659473_1	96561.Dole_2676	2.07e-58	194.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,42P57@68525|delta/epsilon subdivisions,2WM7G@28221|Deltaproteobacteria,2MJ9U@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	PFAM nucleoside H symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_38910_1	641524.ADICYQ_5472	6.81e-09	56.2	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47JYR@768503|Cytophagia	976|Bacteroidetes	P	PFAM sulfatase	mdsA	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_38910_2	713586.KB900536_gene708	1.18e-49	160.0	COG2009@1|root,COG2009@2|Bacteria,1N8VA@1224|Proteobacteria	1224|Proteobacteria	C	succinate dehydrogenase	-	-	-	ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_38910_3	1123072.AUDH01000003_gene784	1.11e-31	114.0	COG2142@1|root,COG2142@2|Bacteria,1MZKE@1224|Proteobacteria,2UDDU@28211|Alphaproteobacteria,2JY8A@204441|Rhodospirillales	204441|Rhodospirillales	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	-	-	-	-	-	-	-	-	-	Sdh_cyt
k59_1014742_1	1000565.METUNv1_03322	2.64e-12	71.2	2C5U9@1|root,30FF7@2|Bacteria,1N2U0@1224|Proteobacteria,2VSBN@28216|Betaproteobacteria,2KWHS@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_71799_1	1089552.KI911559_gene908	7e-65	206.0	COG4136@1|root,COG4136@2|Bacteria,1RA88@1224|Proteobacteria,2U67D@28211|Alphaproteobacteria,2JS0J@204441|Rhodospirillales	204441|Rhodospirillales	S	transport system, ATPase component	-	-	-	ko:K05779	-	M00192	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
k59_527081_1	279530.Q6IWR4_9CAUD	3.61e-44	175.0	4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses  no RNA stage,4QPWY@28883|Caudovirales,4QJW9@10662|Myoviridae	10662|Myoviridae	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1014744_1	1229909.NSED_07840	2.2e-31	114.0	COG1383@1|root,arCOG01885@2157|Archaea,41SUH@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
k59_854830_1	323848.Nmul_A0718	7.25e-106	317.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria,372V3@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_6348_1	305700.B447_00961	4.91e-85	275.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KV42@206389|Rhodocyclales	206389|Rhodocyclales	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_6348_2	1121035.AUCH01000001_gene1981	8.86e-78	244.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,2KU7R@206389|Rhodocyclales	206389|Rhodocyclales	DM	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
k59_953065_1	1231391.AMZF01000018_gene1832	1.1e-63	214.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2VTNQ@28216|Betaproteobacteria,3T83X@506|Alcaligenaceae	28216|Betaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_724612_1	1005048.CFU_1751	4.75e-119	352.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,472V7@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_299673_2	945713.IALB_0034	4.23e-12	68.2	COG0810@1|root,COG1595@1|root,COG0810@2|Bacteria,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	3.4.16.4	ko:K03088,ko:K03112,ko:K03646,ko:K03832,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011,ko02000,ko03021	2.C.1.1,2.C.1.2	-	-	Gram_pos_anchor,Sigma70_r2,TonB_C
k59_887180_1	391038.Bphy_7653	2.55e-90	273.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,2VPNY@28216|Betaproteobacteria,1K7N5@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32,HTH_33
k59_985338_1	1000565.METUNv1_02729	1.8e-128	379.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,2KUBW@206389|Rhodocyclales	206389|Rhodocyclales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_397074_1	626887.J057_07386	6.08e-38	140.0	COG2220@1|root,COG2220@2|Bacteria,1R5GU@1224|Proteobacteria,1SIPM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_233814_1	1276756.AUEX01000001_gene969	4.32e-12	65.9	COG0457@1|root,COG0457@2|Bacteria,1QV5B@1224|Proteobacteria,2WGRP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
k59_233814_2	1158150.KB906243_gene1650	2.75e-70	231.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_854846_1	323848.Nmul_A0639	7.22e-80	264.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,372K8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_822707_1	1122604.JONR01000039_gene3778	2.04e-89	270.0	COG2521@1|root,COG2521@2|Bacteria,1Q0VI@1224|Proteobacteria,1S18J@1236|Gammaproteobacteria,1XC99@135614|Xanthomonadales	135614|Xanthomonadales	S	Methyl-transferase	-	-	-	ko:K06983	-	-	-	-	ko00000	-	-	-	Methyltransf_30
k59_6365_1	743722.Sph21_0233	2.6e-35	125.0	COG1247@1|root,COG1247@2|Bacteria,4NNGH@976|Bacteroidetes,1ISBX@117747|Sphingobacteriia	976|Bacteroidetes	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
k59_6365_2	886293.Sinac_1104	1.33e-11	61.6	COG2128@1|root,COG2128@2|Bacteria,2IZDY@203682|Planctomycetes	203682|Planctomycetes	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_660750_2	402881.Plav_0272	5.74e-64	204.0	COG2885@1|root,COG2885@2|Bacteria,1PFTP@1224|Proteobacteria,2V8N3@28211|Alphaproteobacteria,1JQEZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_234636_1	243090.RB9587	5.08e-34	135.0	COG4715@1|root,COG4715@2|Bacteria	2|Bacteria	S	zinc ion binding	CP_1020	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
k59_785937_1	935557.ATYB01000014_gene1403	8.89e-11	64.3	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2U12A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,Trans_reg_C
k59_203267_1	56780.SYN_03213	1.77e-34	128.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MR3T@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	bamD	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_203267_2	1121918.ARWE01000001_gene3582	3.97e-75	228.0	COG1142@1|root,COG1142@2|Bacteria,1RBG7@1224|Proteobacteria,42R5G@68525|delta/epsilon subdivisions,2WMV5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	bamC-1	-	-	ko:K19516	ko00362,ko01100,ko01120,map00362,map01100,map01120	M00541	R10961	RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_986500_1	246197.MXAN_6601	2.06e-50	179.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,43850@68525|delta/epsilon subdivisions,2WX9Z@28221|Deltaproteobacteria,2YWVT@29|Myxococcales	28221|Deltaproteobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_463026_1	330214.NIDE1522	3.6e-74	229.0	COG0637@1|root,COG0637@2|Bacteria,3J15X@40117|Nitrospirae	40117|Nitrospirae	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_660756_1	1131553.JIBI01000019_gene473	7.89e-18	79.0	COG3807@1|root,COG3807@2|Bacteria,1MZIA@1224|Proteobacteria,2VUTD@28216|Betaproteobacteria,3739U@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_4
k59_660756_2	519989.ECTPHS_01354	5.86e-22	90.5	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales	135613|Chromatiales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_823980_1	857087.Metme_2492	2.82e-55	188.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1XG8U@135618|Methylococcales	135618|Methylococcales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_203273_1	926569.ANT_08040	3.49e-52	174.0	COG1102@1|root,COG1102@2|Bacteria,2G9BR@200795|Chloroflexi	200795|Chloroflexi	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
k59_497522_1	580332.Slit_1447	5.68e-108	332.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2WHYC@28216|Betaproteobacteria,44WNC@713636|Nitrosomonadales	1224|Proteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7
k59_888349_2	767817.Desgi_1127	7.92e-100	301.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,261NS@186807|Peptococcaceae	186801|Clostridia	C	2-oxoacid ferredoxin oxidoreductase, alpha subunit	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_234648_1	523791.Kkor_0209	1.7e-100	315.0	COG0471@1|root,COG0490@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1XHSW@135619|Oceanospirillales	135619|Oceanospirillales	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_366303_1	1041522.MCOL_V204505	2.95e-64	215.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,235TW@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_431565_1	522306.CAP2UW1_3015	2.27e-18	83.6	COG2704@1|root,COG2704@2|Bacteria,1MVHH@1224|Proteobacteria,2VI3D@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane	-	-	-	ko:K07791,ko:K07792	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.13.1	-	-	DcuA_DcuB
k59_431565_2	522306.CAP2UW1_3016	1.14e-47	165.0	COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,2W02M@28216|Betaproteobacteria,1KQIF@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Fumarase C C-terminus	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_497531_1	221988.MS1653	6.85e-52	173.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1Y74P@135625|Pasteurellales	135625|Pasteurellales	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	frdB	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
k59_203287_1	713586.KB900536_gene2399	3.88e-110	325.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,1RQ15@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR_6
k59_856054_1	1121403.AUCV01000004_gene2008	8.42e-57	190.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,42MR9@68525|delta/epsilon subdivisions,2WIP3@28221|Deltaproteobacteria,2MIXN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Aminotransferase class-V	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
k59_954394_1	653948.CCA28199	2.85e-13	70.1	2CM7T@1|root,2QPJK@2759|Eukaryota	2759|Eukaryota	S	plant mutator transposase zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	DBD_Tnp_Mut,MULE,SWIM
k59_954394_2	115417.EPrPW00000015978	8.23e-05	48.5	2D5IT@1|root,2SYQ5@2759|Eukaryota,1MHYE@121069|Pythiales	121069|Pythiales	S	function. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_268728_1	323848.Nmul_A2245	1.47e-81	253.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,371Y0@32003|Nitrosomonadales	28216|Betaproteobacteria	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	icd	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_497553_1	1349767.GJA_4068	5.67e-41	153.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,4726K@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_463066_1	880073.Calab_0065	3.01e-79	260.0	COG0249@1|root,COG0249@2|Bacteria,2NNN6@2323|unclassified Bacteria	2|Bacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_693461_1	391735.Veis_0218	7.92e-84	258.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VPD1@28216|Betaproteobacteria,4AAIP@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_7714_1	1538295.JY96_17135	2.64e-84	274.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,1KJSP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_756868_1	715451.ambt_20260	1.14e-109	335.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,466AZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_693462_1	1288494.EBAPG3_29000	2.35e-62	209.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,371PW@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Peptidase M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_170848_1	1288826.MSNKSG1_17001	6.83e-56	190.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,463ZU@72275|Alteromonadaceae	1236|Gammaproteobacteria	FP	Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the stringent response , an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities	gppA	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006797,GO:0006798,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008894,GO:0009056,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0042594,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:1901360,GO:1901575	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463,iECIAI39_1322.ECIAI39_2643	HD,Ppx-GppA
k59_595251_1	1191523.MROS_1749	5.19e-14	76.6	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	msbA	-	-	ko:K02021,ko:K06147,ko:K06148,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_73131_1	1288494.EBAPG3_11610	2.79e-73	229.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,3724R@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_562802_1	76114.ebA5738	4.51e-56	194.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVJ3@206389|Rhodocyclales	206389|Rhodocyclales	JKL	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k59_856091_1	666681.M301_1174	1.75e-11	65.1	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,2KMD2@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	pilus assembly protein FimV	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	-
k59_856091_2	1005048.CFU_1869	1.23e-189	536.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,472RP@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_268760_1	102232.GLO73106DRAFT_00000250	3.96e-10	70.1	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS_3,PAS_9
k59_562804_1	373994.Riv7116_4461	1.68e-50	173.0	COG1266@1|root,COG1266@2|Bacteria,1G7B7@1117|Cyanobacteria,1HTU6@1161|Nostocales	1117|Cyanobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_627763_1	768671.ThimaDRAFT_4426	3.38e-125	376.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria,1SQA0@1236|Gammaproteobacteria,1X16W@135613|Chromatiales	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_234698_1	1380394.JADL01000010_gene4343	1.77e-93	283.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR3F@28211|Alphaproteobacteria,2JRH0@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_497597_1	1229909.NSED_09935	1.94e-66	206.0	COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_572144_3	864069.MicloDRAFT_00059320	1.17e-20	89.4	28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,2TU05@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_08580	-	-	-	-	-	-	-	-	-	-	-	Endostatin
k59_17145_1	887898.HMPREF0551_2052	2.29e-237	661.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1K2Y1@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_49308_1	861299.J421_1875	1.31e-104	312.0	COG0662@1|root,COG3193@1|root,COG0662@2|Bacteria,COG3193@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Cupin_2,Haem_degrading
k59_82522_1	926556.Echvi_0555	2.35e-43	160.0	COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,47KYP@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_963954_1	1266925.JHVX01000002_gene1047	3e-42	144.0	2DS8M@1|root,33F0H@2|Bacteria,1QWGK@1224|Proteobacteria,2WGZ4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	A domain in the BMP inhibitor chordin and in microbial proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
k59_963954_2	1122221.JHVI01000028_gene1276	2.82e-17	82.8	COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_897056_1	1123504.JQKD01000034_gene2731	1.42e-08	52.4	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,4ADH4@80864|Comamonadaceae	28216|Betaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_897056_2	1163617.SCD_n02521	2.64e-67	206.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2VR5R@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_636869_1	883126.HMPREF9710_04601	1.9e-10	60.8	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,475HT@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_636869_2	999541.bgla_1g09250	2.08e-27	108.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1JZSY@119060|Burkholderiaceae	28216|Betaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
k59_735514_1	1123279.ATUS01000001_gene1922	1e-28	116.0	COG0457@1|root,COG0457@2|Bacteria,1R9C8@1224|Proteobacteria,1RY5F@1236|Gammaproteobacteria,1J63U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8,Transglut_core
k59_147540_2	671143.DAMO_0804	1.2e-44	154.0	COG0583@1|root,COG0583@2|Bacteria,2NPS6@2323|unclassified Bacteria	2|Bacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_343140_1	1128421.JAGA01000002_gene283	1.06e-33	122.0	COG0629@1|root,COG0629@2|Bacteria,2NPUB@2323|unclassified Bacteria	2|Bacteria	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_833699_1	1131266.ARWQ01000010_gene30	1.8e-108	320.0	COG1180@1|root,arCOG00946@2157|Archaea,41SBZ@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_670311_1	1121937.AUHJ01000003_gene3351	1.22e-84	259.0	COG0657@1|root,COG0657@2|Bacteria,1MVRE@1224|Proteobacteria,1S0ZD@1236|Gammaproteobacteria,468F2@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Pectinacetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	PAE
k59_764698_1	1463900.JOIX01000011_gene3211	1.31e-52	177.0	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_865165_1	1569209.BBPH01000183_gene3424	2.69e-12	68.6	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,2PU3N@265|Paracoccus	28211|Alphaproteobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_865165_2	331869.BAL199_12931	3.17e-40	142.0	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,4BRDF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system permease	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_572187_1	945713.IALB_2754	4.98e-52	182.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1,PTR2
k59_114854_1	987059.RBXJA2T_09732	2.36e-85	257.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,1KIU0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	phosphate regulon transcriptional regulatory protein PhoB	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_17196_1	98439.AJLL01000041_gene2536	1.37e-166	481.0	COG0129@1|root,COG0129@2|Bacteria,1G0KD@1117|Cyanobacteria,1JHZB@1189|Stigonemataceae	1117|Cyanobacteria	EG	Dehydratase family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_82566_1	713586.KB900536_gene354	2.31e-19	87.4	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1WVYK@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_441456_1	880072.Desac_2482	4.5e-25	102.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2MQ5Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_18137_1	944546.ABED_1810	3.89e-34	128.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,43AXH@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
k59_532935_1	999141.GME_14695	4.04e-13	69.7	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1XHV5@135619|Oceanospirillales	135619|Oceanospirillales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_532935_2	1232437.KL662020_gene811	5.22e-20	87.4	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2MIGY@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_344103_1	1047013.AQSP01000111_gene1680	1.5e-28	112.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_376186_1	1187851.A33M_1455	3.33e-82	250.0	COG1024@1|root,COG1024@2|Bacteria,1R3SQ@1224|Proteobacteria,2U0FC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_213312_1	1123487.KB892864_gene2204	4.69e-80	247.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,2KVME@206389|Rhodocyclales	206389|Rhodocyclales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_213312_2	1454004.AW11_02971	8.45e-45	157.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,1KQ72@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_344106_1	1232437.KL662006_gene4388	4.6e-28	106.0	2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
k59_471644_1	497321.C664_04207	1.67e-46	152.0	COG1965@1|root,COG1965@2|Bacteria,1RH9A@1224|Proteobacteria,2VVS3@28216|Betaproteobacteria,2KWZ7@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the frataxin	cyaY	-	-	ko:K06202	-	-	-	-	ko00000	-	-	-	Frataxin_Cyay
k59_441472_1	420324.KI912086_gene7328	9.38e-101	303.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,1JU3D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3,DUF1643
k59_18155_1	990285.RGCCGE502_09015	3.94e-37	140.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,4B79R@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_344117_1	876044.IMCC3088_2538	5.14e-105	321.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RYI9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_765552_1	391625.PPSIR1_08941	1.74e-60	203.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2YU9B@29|Myxococcales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_671314_1	1128421.JAGA01000001_gene2055	2.47e-37	141.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
k59_704155_2	1357423.S5M6V7_9CAUD	1.24e-07	50.4	4QDBG@10239|Viruses,4QU7H@28883|Caudovirales,4QI66@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_213340_1	987059.RBXJA2T_07060	2.24e-66	216.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,1KJ0H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_605455_1	1286631.X805_25240	1.89e-119	365.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,1KJTT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_310297_1	1198232.CYCME_0844	4.18e-71	229.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria,4613D@72273|Thiotrichales	72273|Thiotrichales	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.86	ko:K13745	ko00260,ko01120,map00260,map01120	-	R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
k59_376228_1	1267534.KB906754_gene3843	5.72e-17	79.0	COG4430@1|root,COG4430@2|Bacteria,3Y5B3@57723|Acidobacteria,2JJNK@204432|Acidobacteriia	204432|Acidobacteriia	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
k59_376228_2	1300345.LF41_1863	3.56e-29	110.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,1S24F@1236|Gammaproteobacteria,1X4YF@135614|Xanthomonadales	135614|Xanthomonadales	S	Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_115863_1	330214.NIDE4133	3.13e-84	274.0	COG0532@1|root,COG0532@2|Bacteria,3J0CC@40117|Nitrospirae	40117|Nitrospirae	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_148578_1	68219.JNXI01000007_gene1899	3.29e-65	214.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria	201174|Actinobacteria	F	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_834712_1	864073.HFRIS_002159	1.58e-09	56.6	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2VI59@28216|Betaproteobacteria,473JG@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
k59_834712_2	76114.ebA1295	3.48e-86	259.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,2KUCS@206389|Rhodocyclales	206389|Rhodocyclales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_344141_1	497321.C664_10168	3.36e-78	257.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KVC4@206389|Rhodocyclales	206389|Rhodocyclales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_344144_2	485913.Krac_12608	0.000466	43.5	COG1705@1|root,COG3409@1|root,COG1705@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01446,ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
k59_275312_1	318996.AXAZ01000001_gene4789	2.35e-140	431.0	COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
k59_932444_2	1123354.AUDR01000014_gene1091	2.7e-50	180.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1KRBT@119069|Hydrogenophilales	119069|Hydrogenophilales	CM	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
k59_765581_1	670307.HYPDE_30673	4.1e-21	85.9	2C4KB@1|root,32YM4@2|Bacteria,1N74A@1224|Proteobacteria,2UHJ4@28211|Alphaproteobacteria,3N7F3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_18201_1	1187851.A33M_0090	3.62e-56	186.0	COG1638@1|root,COG1638@2|Bacteria,1PJG1@1224|Proteobacteria,2V8IQ@28211|Alphaproteobacteria,3FEKB@34008|Rhodovulum	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_866206_1	1038859.AXAU01000012_gene4371	1.19e-97	295.0	COG0683@1|root,COG0683@2|Bacteria,1MV1Z@1224|Proteobacteria,2TRTD@28211|Alphaproteobacteria,3JRR8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_671354_1	443144.GM21_2187	3.06e-39	145.0	COG0446@1|root,COG0446@2|Bacteria,1QXXG@1224|Proteobacteria	1224|Proteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_637841_1	1123250.KB908385_gene421	6.39e-39	137.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4H4XP@909932|Negativicutes	909932|Negativicutes	M	transglycosylase	ltg	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_637841_2	1535287.JP74_11615	3.19e-16	76.3	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria,3N6XZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_834736_1	1163617.SCD_n00885	5.49e-107	315.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_441523_1	215803.DB30_5881	3.19e-43	159.0	COG3391@1|root,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42Z2U@68525|delta/epsilon subdivisions,2WTYD@28221|Deltaproteobacteria,2YX64@29|Myxococcales	28221|Deltaproteobacteria	S	Cytochrome D1 heme domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1
k59_637844_1	298654.FraEuI1c_7130	5.88e-09	63.2	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4ETX1@85013|Frankiales	201174|Actinobacteria	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,TPR_12
k59_704203_1	391625.PPSIR1_34807	9.1e-100	307.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,4379P@68525|delta/epsilon subdivisions,2X9XU@28221|Deltaproteobacteria,2Z1Y1@29|Myxococcales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_866218_1	83406.HDN1F_06470	3.81e-35	130.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1J8M1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Sulfate adenylate transferase	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_406590_1	1437425.CSEC_2368	3.06e-136	403.0	COG4108@1|root,COG4108@2|Bacteria,2JFKT@204428|Chlamydiae	204428|Chlamydiae	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	-	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
k59_344177_2	1288494.EBAPG3_1770	1.45e-26	107.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,371WH@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_1020689_1	388399.SSE37_21520	2.3e-40	149.0	COG1335@1|root,COG3386@1|root,COG1335@2|Bacteria,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Gluconolactonase	MA20_13995	-	3.1.1.17	ko:K01053,ko:K14274	ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02427,R02933,R03751	RC00537,RC00713,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Isochorismatase,SGL
k59_573282_1	243365.CV_2494	4.21e-22	95.5	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2VJ99@28216|Betaproteobacteria,2KQHT@206351|Neisseriales	206351|Neisseriales	S	VWA domain containing CoxE-like protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_573282_2	757424.Hsero_1612	1.61e-93	280.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,473K5@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_932479_1	765420.OSCT_1338	2.38e-12	71.6	COG2208@1|root,COG2208@2|Bacteria,2G790@200795|Chloroflexi,3773B@32061|Chloroflexia	32061|Chloroflexia	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
k59_671372_1	946483.Cenrod_2372	3.22e-12	73.2	COG0745@1|root,COG3437@1|root,COG4191@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2WI00@28216|Betaproteobacteria,4AGRW@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
k59_671372_2	1437425.CSEC_2368	1.29e-17	84.0	COG4108@1|root,COG4108@2|Bacteria,2JFKT@204428|Chlamydiae	204428|Chlamydiae	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	-	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
k59_508005_1	1207063.P24_01720	6.94e-34	126.0	COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2UB0B@28211|Alphaproteobacteria,2JVQE@204441|Rhodospirillales	204441|Rhodospirillales	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_508005_2	1249627.D779_1941	3.47e-20	100.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,1RRZK@1236|Gammaproteobacteria,1WYNH@135613|Chromatiales	135613|Chromatiales	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100
k59_508005_3	331869.BAL199_17958	1.14e-41	140.0	2DS7S@1|root,33EWX@2|Bacteria,1NDGE@1224|Proteobacteria,2UH4Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_124290_2	85643.Tmz1t_2956	2.04e-11	63.2	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,2KY5Y@206389|Rhodocyclales	206389|Rhodocyclales	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_92308_1	926569.ANT_03170	1.4e-82	259.0	COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi	200795|Chloroflexi	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_712922_1	330214.NIDE1303	4.55e-106	341.0	COG0085@1|root,COG0085@2|Bacteria,3J0CW@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_773222_1	880073.Calab_1598	9.75e-64	220.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
k59_221538_1	1168034.FH5T_01625	4.61e-93	286.0	COG5557@1|root,COG5557@2|Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	hmcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	NrfD
k59_647444_3	1163617.SCD_n02941	3.82e-48	164.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_59608_2	671143.DAMO_0014	1.47e-14	68.9	COG4980@1|root,COG4980@2|Bacteria	2|Bacteria	D	gas vesicle protein	XK27_07760	-	-	-	-	-	-	-	-	-	-	-	YtxH
k59_942445_2	306281.AJLK01000033_gene1523	2.51e-08	58.2	COG0811@1|root,COG0811@2|Bacteria,1G1RE@1117|Cyanobacteria,1JJAZ@1189|Stigonemataceae	1117|Cyanobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_93614_1	1165096.ARWF01000001_gene1915	2.95e-47	169.0	COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,2VJ3A@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,FabA
k59_647448_1	562970.Btus_2217	1.4e-10	67.8	COG5421@1|root,COG5421@2|Bacteria,1UYTK@1239|Firmicutes,4HFCV@91061|Bacilli,278WA@186823|Alicyclobacillaceae	91061|Bacilli	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4277
k59_746703_2	305700.B447_03878	5.38e-44	146.0	COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,2VU39@28216|Betaproteobacteria,2KX0C@206389|Rhodocyclales	206389|Rhodocyclales	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
k59_942451_1	1485544.JQKP01000003_gene249	1.82e-96	289.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,44V8K@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_942451_2	59374.Fisuc_0176	0.000266	43.5	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria	2|Bacteria	E	phosphoribosylanthranilate isomerase activity	trpF	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K01817,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
k59_537800_1	395494.Galf_0272	6.74e-109	329.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,44V78@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_714221_1	1415779.JOMH01000001_gene2953	8.41e-20	94.4	COG4585@1|root,COG4585@2|Bacteria,1R1TC@1224|Proteobacteria,1S4C7@1236|Gammaproteobacteria,1X7VC@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM
k59_975191_1	1121405.dsmv_0958	4.91e-58	194.0	COG1061@1|root,COG1061@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2WJWA@28221|Deltaproteobacteria,2MHPY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	type III restriction protein res subunit	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
k59_450916_1	1158756.AQXQ01000012_gene1997	1.11e-31	113.0	2BK43@1|root,32EHP@2|Bacteria,1RDAC@1224|Proteobacteria,1S4CA@1236|Gammaproteobacteria,1WY9U@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_450916_2	765913.ThidrDRAFT_1498	1.09e-73	225.0	COG1047@1|root,COG1047@2|Bacteria,1REQ1@1224|Proteobacteria,1S2MS@1236|Gammaproteobacteria,1WY6J@135613|Chromatiales	135613|Chromatiales	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	-
k59_583353_1	945713.IALB_1434	1.14e-51	170.0	COG2173@1|root,COG2173@2|Bacteria	2|Bacteria	M	zinc D-Ala-D-Ala carboxypeptidase activity	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
k59_844916_1	452863.Achl_0436	1.64e-42	154.0	COG0657@1|root,COG0657@2|Bacteria,2GNKU@201174|Actinobacteria,1WBVZ@1268|Micrococcaceae	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
k59_615147_1	76114.c1A29	1.93e-22	95.5	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,2KUA5@206389|Rhodocyclales	206389|Rhodocyclales	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_615147_2	1304883.KI912532_gene1	0.000375	42.7	COG0631@1|root,COG0631@2|Bacteria,1N72S@1224|Proteobacteria,2VK9S@28216|Betaproteobacteria,2KVCJ@206389|Rhodocyclales	206389|Rhodocyclales	T	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
k59_450921_1	330214.NIDE2972	2.27e-71	229.0	COG0860@1|root,COG0860@2|Bacteria,3J0MT@40117|Nitrospirae	40117|Nitrospirae	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_158243_1	113395.AXAI01000030_gene2661	1.23e-98	300.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3JSVT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_27979_1	330214.NIDE3770	1.66e-100	302.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_907349_1	330214.NIDE3944	7.91e-71	225.0	COG0577@1|root,COG0577@2|Bacteria,3J0EW@40117|Nitrospirae	40117|Nitrospirae	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_450923_1	945713.IALB_3000	6.49e-105	305.0	COG5405@1|root,COG5405@2|Bacteria	2|Bacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_844926_1	1254432.SCE1572_47310	1.43e-08	57.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_844926_2	1123073.KB899242_gene1279	6.81e-22	95.9	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1X2ZT@135614|Xanthomonadales	135614|Xanthomonadales	E	Acetylornithine deacetylase Succinyl-diaminopimelate	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_714236_1	330214.NIDE1407	1.56e-80	254.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	ko:K02453,ko:K02660	ko02020,ko02025,ko03070,ko05111,map02020,map02025,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	ANAPC5,CarboxypepD_reg,HTH_18,OmpA,PD40,TPR_16,TPR_8,Wzy_C
k59_450928_1	748247.AZKH_0328	2.07e-66	216.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VH96@28216|Betaproteobacteria,2KZ7Z@206389|Rhodocyclales	206389|Rhodocyclales	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_907355_2	1288826.MSNKSG1_09163	7e-76	248.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,464DK@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1006072_1	864051.BurJ1DRAFT_4689	4.73e-81	271.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_158260_1	945713.IALB_0948	2.46e-87	285.0	COG0209@1|root,COG0209@2|Bacteria	2|Bacteria	F	ribonucleoside-diphosphate reductase activity	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
k59_353854_2	945713.IALB_2724	7.39e-120	359.0	COG2192@1|root,COG2192@2|Bacteria	2|Bacteria	O	nodulation	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_27994_1	1121920.AUAU01000008_gene1626	1.14e-33	122.0	COG2197@1|root,COG2197@2|Bacteria,3Y7XN@57723|Acidobacteria	57723|Acidobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_27994_2	159087.Daro_1573	6.39e-21	94.4	COG3437@1|root,COG4585@1|root,COG3437@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria,2KW7P@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Response_reg
k59_647490_1	1002340.AFCF01000033_gene3890	8.79e-19	90.5	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
k59_59648_1	911045.PSE_1502	1.1e-40	147.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2TU7N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	sam	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
k59_615170_1	925409.KI911562_gene2249	6.94e-105	313.0	COG0538@1|root,COG0538@2|Bacteria,4NDY2@976|Bacteroidetes,1INSE@117747|Sphingobacteriia	976|Bacteroidetes	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_450939_1	1032480.MLP_34470	7.24e-13	73.2	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4DQA0@85009|Propionibacteriales	201174|Actinobacteria	H	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_975225_1	742821.HMPREF9464_00773	6.71e-58	194.0	COG3875@1|root,COG3875@2|Bacteria,1R79Y@1224|Proteobacteria,2W07Q@28216|Betaproteobacteria,4PQSG@995019|Sutterellaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_319145_1	945713.IALB_2620	1.32e-68	229.0	COG1198@1|root,COG1198@2|Bacteria	2|Bacteria	L	DNA replication, synthesis of RNA primer	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_583392_2	987059.RBXJA2T_11403	5.35e-29	110.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,1KJ2T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	epsR	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_28011_2	1336208.JADY01000007_gene1629	2.24e-31	123.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,2TSI5@28211|Alphaproteobacteria,2JQU5@204441|Rhodospirillales	204441|Rhodospirillales	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_844958_1	557599.MKAN_27235	1.24e-11	68.6	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,232PA@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	reductase	fabG1	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0018454,GO:0019752,GO:0030497,GO:0032787,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046459,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070402,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059,ko:K11610	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_415040_1	767817.Desgi_2866	1.32e-68	217.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,2618D@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, ATPase component	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_875841_1	290397.Adeh_0294	4.87e-72	233.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,42PZB@68525|delta/epsilon subdivisions,2WK77@28221|Deltaproteobacteria,2YVA7@29|Myxococcales	28221|Deltaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_583403_1	1122599.AUGR01000022_gene1661	8.35e-19	85.5	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,1S0VB@1236|Gammaproteobacteria,1XQZ9@135619|Oceanospirillales	135619|Oceanospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_583403_2	933262.AXAM01000026_gene3064	1.11e-28	106.0	COG2512@1|root,COG2512@2|Bacteria,1NB2J@1224|Proteobacteria,42VKV@68525|delta/epsilon subdivisions,2WS56@28221|Deltaproteobacteria,2MM6F@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_450958_1	414684.RC1_1514	8.73e-45	154.0	COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2UB0B@28211|Alphaproteobacteria,2JVQE@204441|Rhodospirillales	204441|Rhodospirillales	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_450958_2	261292.Nit79A3_2578	7.03e-15	77.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,2W9WV@28216|Betaproteobacteria,373PI@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1006099_1	593907.Celgi_0312	4.75e-41	147.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4F0TD@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_222841_1	1229909.NSED_01460	2.1e-34	120.0	arCOG08822@1|root,arCOG08822@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_793616_1	232721.Ajs_0612	7.66e-76	233.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,4AAQY@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	gltL	-	-	ko:K10004	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	ABC_tran
k59_774295_1	316067.Geob_1226	1.11e-70	236.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TUU@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_450962_2	1123065.ATWL01000013_gene1139	2.32e-27	110.0	COG3021@1|root,COG3021@2|Bacteria,2IPEX@201174|Actinobacteria	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_537825_1	861299.J421_0680	9.4e-85	263.0	COG2072@1|root,COG2072@2|Bacteria,1ZV84@142182|Gemmatimonadetes	2|Bacteria	P	Flavin-binding monooxygenase-like	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_537825_2	479431.Namu_2396	3.61e-09	58.2	COG0596@1|root,COG2197@1|root,COG0596@2|Bacteria,COG2197@2|Bacteria,2GN4Z@201174|Actinobacteria,4EW1H@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE
k59_158311_1	439235.Dalk_5049	6.95e-61	199.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,42QRA@68525|delta/epsilon subdivisions,2WN1V@28221|Deltaproteobacteria,2MK22@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_907402_1	388051.AUFE01000042_gene3441	1.21e-22	95.5	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,1K2JZ@119060|Burkholderiaceae	28216|Betaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_907402_2	365046.Rta_14950	8.28e-73	226.0	28I6Z@1|root,2Z89U@2|Bacteria,1R8YM@1224|Proteobacteria	1224|Proteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_942527_2	555779.Dthio_PD2877	0.000345	45.8	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2M91Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_975265_1	335543.Sfum_0805	1.48e-109	321.0	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,42S1Q@68525|delta/epsilon subdivisions,2WNNS@28221|Deltaproteobacteria,2MQEU@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_280416_1	1123256.KB907925_gene1115	1.41e-18	87.0	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,1XCJP@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
k59_385415_1	1274524.BSONL12_00892	8.51e-29	112.0	COG1028@1|root,COG1028@2|Bacteria,1TPZN@1239|Firmicutes,4HBJ8@91061|Bacilli,1ZF72@1386|Bacillus	91061|Bacilli	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	yvaG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
k59_385415_2	1242864.D187_004287	3.33e-110	337.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42PZH@68525|delta/epsilon subdivisions,2WJ0T@28221|Deltaproteobacteria,2YTTX@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_222853_1	640081.Dsui_0605	5.59e-101	302.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,2KU9J@206389|Rhodocyclales	206389|Rhodocyclales	NU	twitching motility protein	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_844980_1	1123511.KB905841_gene1286	3.33e-40	145.0	COG0500@1|root,COG2226@2|Bacteria,1V7TR@1239|Firmicutes	1239|Firmicutes	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
k59_844980_2	795666.MW7_1791	5.68e-21	91.7	COG3181@1|root,COG3181@2|Bacteria,1NTB7@1224|Proteobacteria,2W167@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_359251_1	1121106.JQKB01000012_gene4671	2.98e-96	290.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,2JZH4@204441|Rhodospirillales	204441|Rhodospirillales	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_522534_1	864051.BurJ1DRAFT_3569	1.63e-89	271.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2VHAS@28216|Betaproteobacteria,1KJ22@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	LD-carboxypeptidase	ldcA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
k59_751069_1	1121937.AUHJ01000010_gene1746	5.04e-55	188.0	COG4188@1|root,COG4188@2|Bacteria,1R6B7@1224|Proteobacteria,1RZ88@1236|Gammaproteobacteria,46DM7@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
k59_718429_1	247490.KSU1_D0847	7.88e-54	181.0	COG0842@1|root,COG0842@2|Bacteria,2J1QC@203682|Planctomycetes	203682|Planctomycetes	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
k59_914359_1	330214.NIDE3046	2.6e-133	402.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_326644_1	443598.AUFA01000002_gene2424	5.47e-166	481.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,3JW5G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_326644_2	639283.Snov_3242	4.27e-19	86.7	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,3EYCK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	EG	Belongs to the IlvD Edd family	MA20_39205	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_261337_1	1382359.JIAL01000001_gene1830	1.43e-15	72.8	COG4911@1|root,COG4911@2|Bacteria,3Y4VB@57723|Acidobacteria,2JJJA@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
k59_196039_1	349520.PPE_00689	2.74e-16	79.7	COG4191@1|root,COG4191@2|Bacteria,1UJKY@1239|Firmicutes,4ITB2@91061|Bacilli,277B1@186822|Paenibacillaceae	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
k59_196039_2	715226.ABI_29480	1.14e-09	60.8	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2V5S6@28211|Alphaproteobacteria,2KHZ3@204458|Caulobacterales	204458|Caulobacterales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_620488_1	1452718.JBOY01000012_gene3280	3.48e-86	256.0	COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,1S2H7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
k59_881695_1	375286.mma_0820	1.18e-42	143.0	COG1917@1|root,COG1917@2|Bacteria,1MYMN@1224|Proteobacteria	1224|Proteobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_979673_1	331678.Cphamn1_0080	6.5e-42	139.0	COG1320@1|root,COG1320@2|Bacteria,1FFAJ@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_979673_2	331678.Cphamn1_0079	2.11e-31	112.0	COG2212@1|root,COG2212@2|Bacteria,1FFC9@1090|Chlorobi	1090|Chlorobi	P	PFAM multiple resistance and pH regulation protein F	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_326654_1	1198232.CYCME_0943	4.39e-30	114.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,460D8@72273|Thiotrichales	72273|Thiotrichales	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_196053_1	945713.IALB_2214	1.54e-64	207.0	COG0275@1|root,COG0275@2|Bacteria	2|Bacteria	J	rRNA processing	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_881702_1	794903.OPIT5_00620	9.05e-05	48.9	COG1840@1|root,COG1840@2|Bacteria,46SF5@74201|Verrucomicrobia,3K7IW@414999|Opitutae	414999|Opitutae	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
k59_685955_1	1104324.P186_0109	7.72e-20	94.4	COG1449@1|root,arCOG03284@2157|Archaea,2XSQ1@28889|Crenarchaeota	28889|Crenarchaeota	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_196219_1	398580.Dshi_0155	1.4e-15	72.4	COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,2UFFT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	effector of murein hydrolase LrgA	lrgA	-	-	ko:K06518	-	-	-	-	ko00000,ko02000	1.E.14.2	-	-	LrgA
k59_196219_2	640081.Dsui_0028	6.82e-41	142.0	COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,2KVYR@206389|Rhodocyclales	206389|Rhodocyclales	M	of murein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	LrgB
k59_490095_1	1297865.APJD01000011_gene6605	6.95e-77	238.0	COG0400@1|root,COG0400@2|Bacteria,1NXXX@1224|Proteobacteria,2UW6X@28211|Alphaproteobacteria,3JX5B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_522717_1	553385.JEMF01000005_gene3486	2.93e-74	235.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1XI4A@135619|Oceanospirillales	135619|Oceanospirillales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_457395_1	1231391.AMZF01000015_gene2250	7.13e-129	389.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,3T8SB@506|Alcaligenaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_979825_1	1121403.AUCV01000031_gene2857	7.96e-60	201.0	29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria,431AV@68525|delta/epsilon subdivisions,2WWN5@28221|Deltaproteobacteria,2MNY5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_359438_1	1123504.JQKD01000013_gene1007	1.59e-96	289.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VH6G@28216|Betaproteobacteria,4ABRZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_947202_2	1370121.AUWS01000045_gene1803	1.88e-24	105.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,234TY@1762|Mycobacteriaceae	201174|Actinobacteria	P	Transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_392109_1	247490.KSU1_D1047	9.31e-26	109.0	COG1840@1|root,COG1840@2|Bacteria,2J39X@203682|Planctomycetes	203682|Planctomycetes	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
k59_979827_1	1266925.JHVX01000013_gene1664	4.05e-70	222.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,371TY@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_979827_2	1458275.AZ34_13865	2.47e-15	72.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,4A9UU@80864|Comamonadaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_326834_1	338963.Pcar_2204	9.54e-65	212.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,43SC6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mur ligase middle domain	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8
k59_457405_1	1123073.KB899242_gene926	5.29e-87	275.0	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1X3FH@135614|Xanthomonadales	135614|Xanthomonadales	Q	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
k59_849218_1	1123256.KB907925_gene1511	4.29e-11	63.2	COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria,1X61X@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
k59_65634_1	416591.Tlet_1936	1.46e-60	192.0	2DYKZ@1|root,34AAD@2|Bacteria	2|Bacteria	L	LAGLIDADG endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	LAGLIDADG_1
k59_849221_1	323848.Nmul_A1953	2.05e-116	355.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,371V5@32003|Nitrosomonadales	28216|Betaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_816613_1	469381.Dpep_0250	6.35e-15	79.0	COG0795@1|root,COG0795@2|Bacteria,3TAEU@508458|Synergistetes	508458|Synergistetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_359448_1	76114.ebA1004	1.42e-77	245.0	COG0657@1|root,COG0657@2|Bacteria,1MV89@1224|Proteobacteria,2VJJC@28216|Betaproteobacteria,2M03F@206389|Rhodocyclales	206389|Rhodocyclales	I	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
k59_881856_2	1198452.Jab_2c22450	1.2e-40	145.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,2VPJI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Selenium-binding protein	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_392123_1	316067.Geob_3476	1.42e-40	148.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2WIP1@28221|Deltaproteobacteria,43TZM@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_326857_1	264198.Reut_A1951	5.14e-24	100.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,1K4T4@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the malate synthase family	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_326857_2	522306.CAP2UW1_2715	5.12e-11	58.9	2CIC8@1|root,33JK4@2|Bacteria,1NH5Z@1224|Proteobacteria,2VYDU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_718636_1	350058.Mvan_3965	8.63e-54	191.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,235IC@1762|Mycobacteriaceae	201174|Actinobacteria	C	ferredoxin oxidoreductase	korA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_457426_1	42256.RradSPS_2099	2.24e-29	110.0	COG3293@1|root,COG3293@2|Bacteria,2IKID@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_718639_1	330214.NIDE0354	2.21e-49	168.0	COG0837@1|root,COG0837@2|Bacteria,3J13D@40117|Nitrospirae	40117|Nitrospirae	F	Glucokinase	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
k59_979855_1	1298867.AUES01000085_gene3659	3.89e-38	140.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_98287_1	1163617.SCD_n01136	0.000121	43.9	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2VHSU@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_98287_2	543913.D521_1685	1.07e-80	247.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2W9ZY@28216|Betaproteobacteria,1KQWA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	-
k59_98287_3	269796.Rru_A1008	3.11e-106	318.0	COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2U0DV@28211|Alphaproteobacteria,2JRFV@204441|Rhodospirillales	204441|Rhodospirillales	O	ADP-ribosylglycohydrolase	draG	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
k59_914575_1	196367.JNFG01000013_gene5110	6.47e-41	149.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,1JZU5@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GTP-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_359468_1	1123228.AUIH01000054_gene3592	6.72e-27	114.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XIJU@135619|Oceanospirillales	135619|Oceanospirillales	V	(ABC) transporter	-	-	-	ko:K11004,ko:K13409	ko02010,ko03070,ko04626,ko05133,map02010,map03070,map04626,map05133	M00325,M00339,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2,3.A.1.110	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_261582_1	1070319.CAGGBEG34_180009	2.02e-07	53.5	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VM1X@28216|Betaproteobacteria,1K2H7@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	General secretion pathway protein F	gspF	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_261582_2	1217718.ALOU01000080_gene3519	2.74e-107	325.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1K2FT@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_457433_1	702113.PP1Y_AT23821	9.11e-21	87.0	COG3350@1|root,COG3350@2|Bacteria,1NI4P@1224|Proteobacteria,2UUZG@28211|Alphaproteobacteria,2KB28@204457|Sphingomonadales	204457|Sphingomonadales	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
k59_457433_2	28258.KP05_16910	1.41e-28	105.0	2E5JD@1|root,330AQ@2|Bacteria,1N86Q@1224|Proteobacteria,1SC9N@1236|Gammaproteobacteria,1XQHW@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_522765_1	1034769.KB910518_gene1640	5.41e-30	120.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,26TK1@186822|Paenibacillaceae	91061|Bacilli	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_783775_1	945713.IALB_1569	1.36e-54	180.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,Peptidase_M23,SH3_3
k59_816646_2	1266925.JHVX01000003_gene516	7.23e-36	131.0	2C1VH@1|root,2Z7Z3@2|Bacteria,1MY5B@1224|Proteobacteria,2VJW2@28216|Betaproteobacteria,372HB@32003|Nitrosomonadales	28216|Betaproteobacteria	S	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase	wbxY	-	-	-	-	-	-	-	-	-	-	-	Kdo_hydroxy
k59_65677_1	945713.IALB_1373	1.19e-60	207.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	treP	-	-	ko:K07126,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,PD40,POTRA
k59_1012355_1	1382356.JQMP01000001_gene1144	2.36e-91	286.0	COG4177@1|root,COG4177@2|Bacteria,2G6D8@200795|Chloroflexi,27Z3V@189775|Thermomicrobia	189775|Thermomicrobia	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_588095_1	420324.KI911943_gene5251	1.08e-91	272.0	COG3335@1|root,COG3335@2|Bacteria,1PPNS@1224|Proteobacteria,2V24H@28211|Alphaproteobacteria,1JY2A@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_653424_1	1283283.ATXA01000041_gene2236	6.09e-52	182.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4ES0H@85013|Frankiales	201174|Actinobacteria	E	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvB2	GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_424809_1	685778.AORL01000025_gene56	1.31e-05	51.6	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2U5B6@28211|Alphaproteobacteria,2K49D@204457|Sphingomonadales	204457|Sphingomonadales	O	maleylacetoacetate isomerase	-	-	5.2.1.2,5.2.1.4	ko:K01800,ko:K01801	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181,R03868	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_C_2,GST_N,GST_N_3
k59_783779_1	795666.MW7_2026	4.17e-83	263.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,1K005@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	ilvG	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_294230_1	443143.GM18_1490	9.13e-17	83.6	COG0457@1|root,COG0457@2|Bacteria,1MZGK@1224|Proteobacteria,42US4@68525|delta/epsilon subdivisions,2X72T@28221|Deltaproteobacteria,43UUN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
k59_881895_1	6334.EFV50597	8.63e-63	214.0	COG0166@1|root,KOG2446@2759|Eukaryota,38EWT@33154|Opisthokonta,3B93W@33208|Metazoa,3CUZG@33213|Bilateria,40B0X@6231|Nematoda	33208|Metazoa	G	Belongs to the GPI family	GPI	GO:0001701,GO:0001704,GO:0001707,GO:0001775,GO:0002252,GO:0002262,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002637,GO:0002639,GO:0002682,GO:0002684,GO:0002697,GO:0002699,GO:0002700,GO:0002702,GO:0002791,GO:0002793,GO:0003008,GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006950,GO:0006955,GO:0006959,GO:0007275,GO:0007369,GO:0007498,GO:0007599,GO:0007610,GO:0007611,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009410,GO:0009435,GO:0009438,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009888,GO:0009892,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0010466,GO:0010594,GO:0010595,GO:0010605,GO:0010632,GO:0010634,GO:0010941,GO:0010951,GO:0012505,GO:0014070,GO:0014072,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016192,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0016866,GO:0017144,GO:0018130,GO:0019222,GO:0019242,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0019899,GO:0030141,GO:0030162,GO:0030246,GO:0030334,GO:0030335,GO:0031090,GO:0031253,GO:0031323,GO:0031324,GO:0031410,GO:0031625,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032268,GO:0032269,GO:0032355,GO:0032501,GO:0032502,GO:0032570,GO:0032787,GO:0032879,GO:0032880,GO:0032940,GO:0033500,GO:0033574,GO:0033993,GO:0034101,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034774,GO:0035902,GO:0035994,GO:0036094,GO:0036230,GO:0040012,GO:0040017,GO:0042119,GO:0042180,GO:0042181,GO:0042221,GO:0042493,GO:0042592,GO:0042593,GO:0042866,GO:0042981,GO:0042995,GO:0043005,GO:0043009,GO:0043066,GO:0043067,GO:0043069,GO:0043086,GO:0043154,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043278,GO:0043279,GO:0043281,GO:0043299,GO:0043312,GO:0043436,GO:0043523,GO:0043524,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045055,GO:0045321,GO:0045861,GO:0046031,GO:0046034,GO:0046184,GO:0046185,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046686,GO:0046700,GO:0046903,GO:0046939,GO:0048029,GO:0048332,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048545,GO:0048598,GO:0048646,GO:0048729,GO:0048856,GO:0048872,GO:0048878,GO:0050708,GO:0050714,GO:0050789,GO:0050790,GO:0050794,GO:0050877,GO:0050878,GO:0050890,GO:0050896,GO:0051023,GO:0051024,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051156,GO:0051171,GO:0051172,GO:0051179,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051270,GO:0051272,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060170,GO:0060205,GO:0060255,GO:0060359,GO:0060548,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0071704,GO:0071944,GO:0072330,GO:0072347,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097458,GO:0097708,GO:0098588,GO:0098590,GO:0099503,GO:0101002,GO:0120025,GO:0120038,GO:1901135,GO:1901137,GO:1901214,GO:1901215,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901654,GO:1901698,GO:1901700,GO:1903530,GO:1903532,GO:1904813,GO:1904951,GO:2000116,GO:2000117,GO:2000145,GO:2000147	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_979881_1	398525.KB900701_gene6702	5.07e-130	392.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_163650_1	105559.Nwat_2730	3.74e-61	208.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_947255_1	436308.Nmar_1782	7.08e-113	337.0	COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
k59_620747_1	34506.g2227	1.4e-14	75.9	COG0524@1|root,COG0642@1|root,KOG0519@2759|Eukaryota,KOG2855@2759|Eukaryota	2759|Eukaryota	G	carbohydrate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PfkB,Response_reg
k59_620747_2	933262.AXAM01000002_gene562	5.23e-30	112.0	COG2204@1|root,COG2204@2|Bacteria,1RGQT@1224|Proteobacteria,42RK9@68525|delta/epsilon subdivisions,2WMYQ@28221|Deltaproteobacteria,2MJRF@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_620747_3	313595.P700755_003024	2.46e-05	46.2	COG0642@1|root,COG2205@2|Bacteria,4NG0Y@976|Bacteroidetes,1HXCZ@117743|Flavobacteriia,4C348@83612|Psychroflexus	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
k59_359495_1	945713.IALB_0211	5.05e-08	54.3	COG0010@1|root,COG0010@2|Bacteria	2|Bacteria	E	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	rocF	GO:0003674,GO:0003824,GO:0004053,GO:0006082,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_103293_1	1121861.KB899928_gene1505	7.17e-81	250.0	COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria,2TTQ8@28211|Alphaproteobacteria,2JRAH@204441|Rhodospirillales	204441|Rhodospirillales	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_331722_1	43989.cce_3952	2.07e-06	47.8	COG0590@1|root,COG0590@2|Bacteria,1G534@1117|Cyanobacteria,3KHPY@43988|Cyanothece	1117|Cyanobacteria	FJ	PFAM CMP dCMP deaminase zinc-binding	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	MafB19-deam,dCMP_cyt_deam_1
k59_136013_1	1123023.JIAI01000001_gene7333	6.43e-71	229.0	COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,2GKV9@201174|Actinobacteria	201174|Actinobacteria	I	3-oxoacid CoA-transferase, B subunit	pcaJ	-	2.8.3.5	ko:K01027,ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_461472_1	177437.HRM2_22370	3.16e-49	161.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2WP4D@28221|Deltaproteobacteria,2MKC0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Hydrogenase maturation protease	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_461472_2	439235.Dalk_2276	5.31e-78	248.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,2MI12@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hynA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6	ko:K00437,ko:K00533,ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R00019,R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_853886_1	580332.Slit_1466	4.26e-59	197.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,44V7R@713636|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_853886_2	987059.RBXJA2T_14696	1.74e-31	121.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,1KIYR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_724776_1	546271.Selsp_1713	1.67e-68	217.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H2KH@909932|Negativicutes	909932|Negativicutes	E	ABC transporter, ATP-binding protein	glnQ3	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k59_854992_1	945713.IALB_0634	2.39e-47	164.0	COG1463@1|root,COG1463@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	ttg2C	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_202246_1	330214.NIDE1360	1.61e-108	324.0	COG0004@1|root,COG0004@2|Bacteria,3J0IS@40117|Nitrospirae	40117|Nitrospirae	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_692283_1	1229909.NSED_09295	8.95e-62	191.0	arCOG08766@1|root,arCOG08766@2157|Archaea,41T41@651137|Thaumarchaeota	651137|Thaumarchaeota	G	dUTPase	-	-	-	-	-	-	-	-	-	-	-	-	dUTPase_2
k59_692283_2	436308.Nmar_1747	2.15e-43	145.0	COG4063@1|root,arCOG03220@2157|Archaea,41T46@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrahydromethanopterin S-methyltransferase, subunit A	-	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
k59_332867_1	999541.bgla_1g09630	1.39e-46	158.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2VQ2F@28216|Betaproteobacteria,1K2YK@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
k59_332867_2	1123487.KB892838_gene3821	1e-20	90.1	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,2KUWK@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	cmk	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
k59_724788_1	1266925.JHVX01000006_gene2151	1.87e-65	206.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,372G8@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_137141_1	1366050.N234_29405	5.77e-64	214.0	COG2159@1|root,COG2159@2|Bacteria,1N4SA@1224|Proteobacteria,2W2QV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_692285_1	323848.Nmul_A2468	1.12e-99	319.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_692285_2	76114.ebA3910	3.14e-79	242.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VR5A@28216|Betaproteobacteria,2KW48@206389|Rhodocyclales	206389|Rhodocyclales	V	Negative regulator of beta-lactamase expression	ampD	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
k59_267661_1	1133850.SHJG_8047	8.3e-22	88.2	COG4274@1|root,COG4274@2|Bacteria,2IN0N@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
k59_267661_2	629773.AORY01000004_gene21	4.7e-18	82.8	COG0625@1|root,COG0625@2|Bacteria,1N8XH@1224|Proteobacteria,2TTHQ@28211|Alphaproteobacteria,2K1AK@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3
k59_72008_1	395493.BegalDRAFT_1633	3.05e-74	233.0	COG1907@1|root,COG1907@2|Bacteria,1MWHM@1224|Proteobacteria,1RQC1@1236|Gammaproteobacteria,4629S@72273|Thiotrichales	72273|Thiotrichales	S	PFAM GHMP kinases C terminal	-	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_6547_1	926569.ANT_17990	1.19e-83	253.0	COG2345@1|root,COG2345@2|Bacteria,2G79S@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_887351_1	530564.Psta_0890	1.59e-33	125.0	COG3293@1|root,COG3293@2|Bacteria,2IZ9E@203682|Planctomycetes	203682|Planctomycetes	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_785614_1	96561.Dole_0551	5.07e-13	69.7	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2MISS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_785614_2	76114.ebA3154	2.08e-05	47.8	2C5U9@1|root,30FF7@2|Bacteria,1N2U0@1224|Proteobacteria,2WIIE@28216|Betaproteobacteria,2M01U@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_202265_1	1217718.ALOU01000020_gene2166	4.44e-12	66.6	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,1KIFR@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_202265_2	264198.Reut_A1791	5.13e-89	275.0	COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,2W02M@28216|Betaproteobacteria,1K2CS@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Aspartate ammonia-lyase	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_496448_1	1121937.AUHJ01000011_gene2842	2.03e-116	342.0	COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,1S7XK@1236|Gammaproteobacteria,4655T@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_6548_2	675635.Psed_5052	3.88e-06	49.7	COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria	201174|Actinobacteria	CH	amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_822896_1	270374.MELB17_16898	2.04e-06	49.7	COG4665@1|root,COG4665@2|Bacteria,1N0FY@1224|Proteobacteria,1SEJB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_822896_2	388399.SSE37_07183	1.79e-53	179.0	COG1638@1|root,COG1638@2|Bacteria,1MUBS@1224|Proteobacteria,2TUKV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_822898_1	391596.PBAL39_18774	3.27e-41	144.0	COG0500@1|root,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,1IP66@117747|Sphingobacteriia	976|Bacteroidetes	Q	Methylase involved in ubiquinone menaquinone biosynthesis	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
k59_822898_2	1191523.MROS_1043	5.62e-54	172.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_332888_2	1123487.KB892835_gene3501	1.78e-11	60.1	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2VTYY@28216|Betaproteobacteria,2KWZ9@206389|Rhodocyclales	206389|Rhodocyclales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_6557_1	398527.Bphyt_3546	2.03e-51	176.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,1K0VU@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	degQ	-	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_430570_1	1451261.AS96_04890	4.07e-86	276.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,2GJ5U@201174|Actinobacteria,4FK9Z@85023|Microbacteriaceae	201174|Actinobacteria	C	belongs to the CobB CobQ family	pta	GO:0005575,GO:0005576	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_659715_1	1459636.NTE_03123	2.6e-116	348.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k59_887369_1	880073.Calab_1578	6.82e-45	163.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_39137_2	930169.B5T_00016	1.7e-53	173.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,1S25K@1236|Gammaproteobacteria,1XJCI@135619|Oceanospirillales	135619|Oceanospirillales	L	DNA-3-methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_39139_1	1288494.EBAPG3_2050	2.18e-37	125.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,373I5@32003|Nitrosomonadales	28216|Betaproteobacteria	K	PFAM Cold-shock protein, DNA-binding	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_169774_1	365528.KB891283_gene3355	8.03e-44	157.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4EX8X@85013|Frankiales	201174|Actinobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_72037_1	714943.Mucpa_1117	1.35e-12	67.0	COG0821@1|root,COG0821@2|Bacteria,4NE63@976|Bacteroidetes,1IQVN@117747|Sphingobacteriia	976|Bacteroidetes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_72037_2	304371.MCP_2085	4.62e-07	55.1	COG0693@1|root,arCOG00769@2157|Archaea	304371.MCP_2085|-	C	Intracellular protease	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_822923_1	1238186.AOCN01000019_gene498	1.75e-38	139.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria,4FKHG@85023|Microbacteriaceae	201174|Actinobacteria	T	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
k59_6577_1	945713.IALB_2968	1.06e-13	70.1	COG2265@1|root,COG2265@2|Bacteria	2|Bacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_6577_2	945713.IALB_2969	5.9e-59	189.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	bioC	-	2.1.1.187,2.1.1.197	ko:K00563,ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R07233,R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_332911_1	411465.PEPMIC_01548	1.48e-12	67.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,22J74@1570339|Peptoniphilaceae	186801|Clostridia	C	Molybdopterin oxidoreductase Fe4S4 domain	nuoG	-	1.17.1.10,1.6.5.3	ko:K00336,ko:K05299	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_332911_2	1121472.AQWN01000004_gene810	2.43e-26	110.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,260R6@186807|Peptococcaceae	186801|Clostridia	C	NADH dehydrogenase	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_594191_1	335543.Sfum_2118	6.37e-59	200.0	COG0539@1|root,COG1093@1|root,COG0539@2|Bacteria,COG1093@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MR1P@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_724836_1	864073.HFRIS_015651	7.05e-98	308.0	COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2VKMT@28216|Betaproteobacteria,47915@75682|Oxalobacteraceae	28216|Betaproteobacteria	EG	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_496488_1	794903.OPIT5_17850	5.33e-15	74.7	COG2823@1|root,COG2823@2|Bacteria,46XV8@74201|Verrucomicrobia,3K8D0@414999|Opitutae	414999|Opitutae	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_496488_2	754477.Q7C_1944	6.18e-16	77.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,45ZZX@72273|Thiotrichales	72273|Thiotrichales	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	DUF229,HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
k59_985543_1	323848.Nmul_A1055	9.99e-70	227.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,372FQ@32003|Nitrosomonadales	28216|Betaproteobacteria	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_822937_1	264730.PSPPH_A0061	2.93e-61	198.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1Z7QZ@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_137200_1	107636.JQNK01000008_gene4111	2.08e-53	177.0	COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria,2TVHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD, TfdA family	MA20_18150	-	-	ko:K06912	ko00361,ko01120,ko01220,map00361,map01120,map01220	-	R05419,R05493	RC01371,RC01372	ko00000,ko00001,ko01000	-	-	-	TauD
k59_724840_2	1249627.D779_3018	1.39e-23	94.4	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1WYGA@135613|Chromatiales	135613|Chromatiales	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
k59_887394_1	1123053.AUDG01000008_gene3596	9.12e-33	123.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1WY4Z@135613|Chromatiales	135613|Chromatiales	NU	PFAM Fimbrial assembly	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_365340_1	926569.ANT_06670	1.67e-100	309.0	COG0747@1|root,COG0747@2|Bacteria,2G5NA@200795|Chloroflexi	200795|Chloroflexi	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_299901_1	706587.Desti_3484	6.09e-26	113.0	COG3464@1|root,COG3464@2|Bacteria,1QZI9@1224|Proteobacteria,43CJK@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_985554_1	436308.Nmar_1717	1.47e-119	350.0	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
k59_985557_1	395495.Lcho_3893	5.18e-96	313.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_104484_1	991905.SL003B_2672	2.77e-66	216.0	COG0742@1|root,COG0742@2|Bacteria,1MW6A@1224|Proteobacteria,2TQNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ribosomal rna small subunit methyltransferase	MA20_07810	-	-	-	-	-	-	-	-	-	-	-	-
k59_1014877_1	990285.RGCCGE502_05265	1.13e-63	210.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TT6V@28211|Alphaproteobacteria,4BA39@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Chloride channel protein	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_822960_1	497321.C664_17987	6.1e-18	81.6	COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,2KUYN@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0810 Periplasmic protein TonB, links inner and outer membranes	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_822960_2	413404.Rmag_0435	1.35e-49	168.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1J5D3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726	Shikimate_DH,Shikimate_dh_N
k59_430616_1	570967.JMLV01000001_gene2640	2.83e-29	117.0	COG2223@1|root,COG2223@2|Bacteria,1QWEE@1224|Proteobacteria,2TWX6@28211|Alphaproteobacteria,2JYYQ@204441|Rhodospirillales	204441|Rhodospirillales	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_72086_1	257310.BB1998	3.52e-82	261.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,3T5BW@506|Alcaligenaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_561732_1	1288494.EBAPG3_27420	2.38e-77	239.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,371UX@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Exodeoxyribonuclease III xth	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_72092_1	1123367.C666_12140	1.68e-60	192.0	COG0500@1|root,COG0500@2|Bacteria,1QU9M@1224|Proteobacteria,2WGK0@28216|Betaproteobacteria,2KWMJ@206389|Rhodocyclales	206389|Rhodocyclales	Q	tellurite resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
k59_496534_1	639283.Snov_0188	2.28e-141	407.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,3EYRF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_822984_1	323848.Nmul_A0211	6.82e-81	243.0	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,2VQ18@28216|Betaproteobacteria,372RY@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
k59_822984_2	292415.Tbd_0176	1.94e-17	81.6	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2VKQB@28216|Betaproteobacteria	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_985594_1	768671.ThimaDRAFT_3566	4.73e-94	298.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,1T5B8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_104516_2	671143.DAMO_1309	1.93e-83	248.0	COG1943@1|root,COG1943@2|Bacteria,2NRRG@2323|unclassified Bacteria	2|Bacteria	L	Transposase IS200 like	isplu5A	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_299951_1	1459636.NTE_02223	2.69e-59	199.0	COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota	651137|Thaumarchaeota	M	TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_6661_1	314278.NB231_16333	1.81e-88	278.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1WVYK@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_365393_1	1038859.AXAU01000001_gene2808	9.18e-08	51.2	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TU0G@28211|Alphaproteobacteria,3JSWW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_823008_1	1507.HMPREF0262_02680	9.6e-91	285.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,36DE5@31979|Clostridiaceae	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
k59_995606_2	1235457.C404_17925	1.51e-27	108.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,1JZQY@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_636880_6	1206729.BAFZ01000038_gene4895	8.72e-50	196.0	COG1372@1|root,COG1702@1|root,COG1372@2|Bacteria,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4FW6M@85025|Nocardiaceae	201174|Actinobacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_995612_1	1042375.AFPL01000025_gene1198	1.65e-25	101.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
k59_17210_1	159087.Daro_4106	3.24e-11	63.2	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,2KU8M@206389|Rhodocyclales	206389|Rhodocyclales	K	Belongs to the ParB family	spoOJ	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_17210_2	1159870.KB907784_gene1225	1.39e-45	155.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,3T2XR@506|Alcaligenaceae	28216|Betaproteobacteria	D	chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_931453_1	1304885.AUEY01000074_gene592	3.31e-60	197.0	COG2605@1|root,COG2605@2|Bacteria,1QW1A@1224|Proteobacteria,42N0X@68525|delta/epsilon subdivisions,2WJYP@28221|Deltaproteobacteria,2MHZ0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM GHMP kinase	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_789237_1	1296416.JACB01000044_gene4985	0.000647	48.1	COG2267@1|root,COG2267@2|Bacteria,4NKKQ@976|Bacteroidetes,1I718@117743|Flavobacteriia,2YI1X@290174|Aquimarina	976|Bacteroidetes	I	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_440545_1	1122214.AQWH01000039_gene4763	1.07e-86	273.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_470837_1	292415.Tbd_2028	8.96e-141	419.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,1KSX1@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1020210_1	1121405.dsmv_1721	2.12e-69	225.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MIIU@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1020210_2	477974.Daud_0641	2.2e-11	63.5	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,260H7@186807|Peptococcaceae	186801|Clostridia	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_242424_1	358220.C380_13195	1.15e-103	318.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,4AABZ@80864|Comamonadaceae	28216|Betaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,HD_5
k59_309404_1	1454004.AW11_03085	6.76e-104	325.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_180095_1	96561.Dole_0718	6.24e-69	209.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,42RHR@68525|delta/epsilon subdivisions,2WNEK@28221|Deltaproteobacteria,2MJSK@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_180095_2	767817.Desgi_0374	3.52e-16	72.4	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,262K7@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_405736_1	159087.Daro_1003	3.81e-18	87.4	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VM1W@28216|Betaproteobacteria,2KXH9@206389|Rhodocyclales	206389|Rhodocyclales	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
k59_82594_1	228410.NE0105	6.71e-89	268.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2VHEW@28216|Betaproteobacteria,372K4@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_506963_1	1298867.AUES01000066_gene4685	3.2e-45	165.0	COG1572@1|root,COG1572@2|Bacteria,1QVRG@1224|Proteobacteria	1224|Proteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	ko:K20952	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Beta-prism_lec,Calx-beta,DUF5122
k59_995631_2	493475.GARC_0017	2.29e-19	83.6	2C19Z@1|root,2Z826@2|Bacteria,1RBG1@1224|Proteobacteria,1RZFJ@1236|Gammaproteobacteria,466TC@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_789242_1	795666.MW7_2454	5e-84	275.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1K5NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_833751_1	977880.RALTA_A2193	5.92e-77	237.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2VM9Q@28216|Betaproteobacteria,1K4QS@119060|Burkholderiaceae	28216|Betaproteobacteria	P	membrane protein, TerC	terC	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_147607_1	330214.NIDE0784	1.22e-116	345.0	COG5274@1|root,COG5274@2|Bacteria	2|Bacteria	C	heme binding	-	-	1.13.11.52	ko:K00463	ko00380,ko01100,ko05143,map00380,map01100,map05143	M00038	R00678,R02702,R02909,R03628	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyt-b5,FAD_binding_1,IDO,NAD_binding_1
k59_82601_1	204773.HEAR1220	1.55e-28	117.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,473WU@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	LysM domain	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
k59_242450_1	330214.NIDE3730	1.13e-77	244.0	COG0612@1|root,COG0612@2|Bacteria,3J0I5@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_833768_1	338963.Pcar_0550	4.63e-34	121.0	COG0231@1|root,COG0231@2|Bacteria,1NWY9@1224|Proteobacteria,42PYR@68525|delta/epsilon subdivisions,2WJQF@28221|Deltaproteobacteria,43VE8@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Elongation factor P, C-terminal	efp-1	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_833768_2	1232410.KI421415_gene2971	9.43e-35	122.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2WNG7@28221|Deltaproteobacteria,43RYJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Elongation factor P (EF-P) OB domain	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_764759_1	266940.Krad_1722	2.49e-46	165.0	2DBV2@1|root,2ZB9E@2|Bacteria	2|Bacteria	S	Phage portal protein, SPP1 Gp6-like	-	-	-	-	-	-	-	-	-	-	-	-	Phage_prot_Gp6
k59_833772_2	595537.Varpa_1731	1.69e-28	112.0	COG0477@1|root,COG2814@2|Bacteria,1MVKJ@1224|Proteobacteria,2VK6H@28216|Betaproteobacteria,4AD0T@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
k59_670389_1	1123393.KB891326_gene42	3.21e-101	329.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,1KSRI@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_309449_1	1121935.AQXX01000059_gene1971	3.16e-11	66.6	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,1SZTB@1236|Gammaproteobacteria,1XRNY@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114914_1	330214.NIDE4126	1.07e-107	324.0	COG0612@1|root,COG0612@2|Bacteria,3J0GS@40117|Nitrospirae	40117|Nitrospirae	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_17273_1	545264.KB898744_gene2083	5.73e-30	111.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1WXPI@135613|Chromatiales	135613|Chromatiales	F	phosphoribosyltransferase	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_17273_2	292.DM42_963	9.78e-62	200.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,1JZN1@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_670392_1	589924.Ferp_2111	4.6e-52	181.0	COG0111@1|root,COG0440@1|root,arCOG01754@2157|Archaea,arCOG04445@2157|Archaea,2XU9V@28890|Euryarchaeota,246MG@183980|Archaeoglobi	183980|Archaeoglobi	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_572270_1	261292.Nit79A3_1141	1.1e-50	178.0	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,372NQ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_995673_1	483219.LILAB_08880	1.67e-41	155.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions	1224|Proteobacteria	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_440603_2	1158292.JPOE01000005_gene1144	1.2e-68	220.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1KKHM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_17280_1	1123393.KB891316_gene1582	6.66e-76	248.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,1KSPS@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_180162_1	1336208.JADY01000001_gene807	8.34e-75	234.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,2TQS6@28211|Alphaproteobacteria,2JPSI@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
k59_764770_1	1121004.ATVC01000013_gene2062	1.59e-63	206.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,2KPC7@206351|Neisseriales	206351|Neisseriales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_764770_2	1266925.JHVX01000003_gene569	3.05e-143	424.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,3726D@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_764770_3	1000565.METUNv1_02877	1.91e-06	49.3	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
k59_114930_1	1232410.KI421418_gene2194	1.06e-39	144.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,43S6Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	DnaJ_C,Rhomboid
k59_242479_1	639283.Snov_2116	1.63e-73	232.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,3F0VG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
k59_833796_1	748280.NH8B_3981	2.63e-116	358.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,2KPX4@206351|Neisseriales	206351|Neisseriales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_49447_1	349102.Rsph17025_1552	1.88e-17	86.7	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_405793_1	314287.GB2207_03559	5.07e-78	238.0	COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria,1S2SV@1236|Gammaproteobacteria,1J6Q3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Las17-binding protein actin regulator	VPA0371	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_833800_2	556268.OFAG_01429	4e-23	97.1	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VS5A@28216|Betaproteobacteria,478H6@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
k59_865276_2	1288494.EBAPG3_29800	2.47e-69	216.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2VJ3V@28216|Betaproteobacteria,372N2@32003|Nitrosomonadales	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_670422_2	1121004.ATVC01000015_gene2106	2.33e-90	272.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,2KPXQ@206351|Neisseriales	206351|Neisseriales	K	Psort location Cytoplasmic, score 9.97	qseB	-	-	ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_964109_1	909663.KI867150_gene2220	1.24e-66	216.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,43C8U@68525|delta/epsilon subdivisions,2X7J6@28221|Deltaproteobacteria,2MSKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_833806_1	460265.Mnod_6181	1e-78	248.0	COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria,2U4GU@28211|Alphaproteobacteria,1JWE1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Involved in initiation control of chromosome replication	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
k59_82664_1	883126.HMPREF9710_02748	2.22e-95	285.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2VHSP@28216|Betaproteobacteria,475ZF@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	abmC	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_82664_2	1415166.NONO_c06720	5.06e-13	68.9	COG1309@1|root,COG1309@2|Bacteria,2IDV2@201174|Actinobacteria,4FYD0@85025|Nocardiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_242487_1	164757.Mjls_5725	1.16e-27	115.0	COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,236EU@1762|Mycobacteriaceae	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_242487_2	1165096.ARWF01000001_gene2295	5.02e-59	194.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,2KMC3@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_343270_1	553385.JEMF01000006_gene3378	2.17e-12	65.1	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1XI8V@135619|Oceanospirillales	135619|Oceanospirillales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_343270_2	1335757.SPICUR_08290	8.52e-50	168.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales	135613|Chromatiales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_572309_2	652103.Rpdx1_4276	7.18e-49	169.0	COG0742@1|root,COG0742@2|Bacteria,1MW6A@1224|Proteobacteria,2TQNI@28211|Alphaproteobacteria,3JR22@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	ribosomal rna small subunit methyltransferase	MA20_07810	-	-	-	-	-	-	-	-	-	-	-	-
k59_375372_1	1288494.EBAPG3_20640	2.44e-81	255.0	COG1488@1|root,COG1488@2|Bacteria,1QRUH@1224|Proteobacteria,2W9XI@28216|Betaproteobacteria,372JT@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
k59_309492_1	595536.ADVE02000001_gene2744	6.13e-106	320.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2U105@28211|Alphaproteobacteria,36ZBI@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_82677_1	1169143.KB911035_gene2453	1.83e-110	342.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria,1JZQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_931566_1	1100720.ALKN01000052_gene507	2.05e-46	164.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_242503_1	945713.IALB_0801	1.89e-71	231.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7
k59_764804_1	1459636.NTE_01445	6.7e-28	108.0	arCOG08754@1|root,arCOG08754@2157|Archaea,41SUV@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_931573_1	1122604.JONR01000035_gene378	5.37e-06	46.6	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1X5XV@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_931573_2	323848.Nmul_A0361	2.77e-42	143.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2VRRV@28216|Betaproteobacteria,373F4@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_375392_1	987059.RBXJA2T_03708	2.74e-24	108.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,1KNBM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	PAS fold	-	-	2.7.13.3	ko:K11527,ko:K20973	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
k59_670458_1	395495.Lcho_4123	5.79e-54	191.0	COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria,1KN2G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_637015_1	1380355.JNIJ01000041_gene5219	2.06e-77	243.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_50430_1	1205680.CAKO01000006_gene3206	5.84e-37	139.0	COG0405@1|root,COG0405@2|Bacteria,1MXXD@1224|Proteobacteria,2TSB2@28211|Alphaproteobacteria,2JQ6M@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_441580_1	1279019.ARQK01000025_gene2376	3.15e-186	544.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_243358_1	1122132.AQYH01000002_gene1283	5.36e-111	335.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,4BAGU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_181135_1	945713.IALB_0645	4.46e-62	206.0	COG1530@1|root,COG1530@2|Bacteria	2|Bacteria	J	ribonuclease E activity	rng	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_644575_2	1121035.AUCH01000008_gene1047	8.76e-12	63.9	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2VIA5@28216|Betaproteobacteria,2KUG6@206389|Rhodocyclales	206389|Rhodocyclales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_1003124_1	468059.AUHA01000004_gene2346	2.06e-21	98.2	COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,1IVAH@117747|Sphingobacteriia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH,Ig_2,Malectin,PKD,VCBS,fn3
k59_382531_1	1254432.SCE1572_16030	2.89e-129	384.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,42NPA@68525|delta/epsilon subdivisions,2WT46@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_412526_2	1122139.KB907882_gene83	9.87e-33	122.0	COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,1RQHJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate	fbaB	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_2236,iSBO_1134.SBO_0918,iUMNK88_1353.UMNK88_2640	DeoC
k59_187389_1	224911.27351364	5.64e-37	142.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_219947_1	977880.RALTA_A2407	1.92e-111	334.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,1K0Y8@119060|Burkholderiaceae	28216|Betaproteobacteria	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_187390_1	1396418.BATQ01000189_gene762	3.72e-114	347.0	COG3344@1|root,COG3344@2|Bacteria,46TQ6@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_155390_1	948106.AWZT01000006_gene3332	1.91e-85	270.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1K0F2@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_412535_1	189753.AXAS01000008_gene6759	7.76e-16	80.5	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JUJ0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_514896_1	382245.ASA_2131	1.07e-32	120.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,1RP0B@1236|Gammaproteobacteria,1Y5BU@135624|Aeromonadales	135624|Aeromonadales	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
k59_872883_1	945713.IALB_1553	5.93e-53	169.0	COG0736@1|root,COG0736@2|Bacteria	2|Bacteria	I	holo-[acyl-carrier-protein] synthase activity	acpS	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	2.7.6.3,2.7.8.7,3.2.1.52,4.3.1.14,5.1.1.1	ko:K00950,ko:K00997,ko:K01207,ko:K01775,ko:K06133,ko:K06925,ko:K18014	ko00310,ko00473,ko00520,ko00531,ko00770,ko00790,ko01100,ko01501,ko01502,map00310,map00473,map00520,map00531,map00770,map00790,map01100,map01501,map01502	M00126,M00628,M00841	R00022,R00401,R01625,R03030,R03503,R05963,R07809,R07810,R10831	RC00002,RC00017,RC00049,RC00285,RC00833	ko00000,ko00001,ko00002,ko01000,ko01011,ko03016	-	-	iYO844.BSU04620	ACPS
k59_904486_1	748247.AZKH_1721	1.33e-52	187.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,2KUB6@206389|Rhodocyclales	206389|Rhodocyclales	ET	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_155394_1	1033732.CAHI01000030_gene959	1.72e-46	160.0	COG0492@1|root,COG0492@2|Bacteria,4NEVX@976|Bacteroidetes,2FMNF@200643|Bacteroidia,22UAQ@171550|Rikenellaceae	976|Bacteroidetes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_90625_1	330214.NIDE0250	3.31e-101	307.0	COG0531@1|root,COG0531@2|Bacteria,3J0ZY@40117|Nitrospirae	40117|Nitrospirae	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_412545_1	626418.bglu_2g16010	0.000788	47.4	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1K0FY@119060|Burkholderiaceae	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_972112_1	760568.Desku_0598	4.54e-21	97.4	COG2203@1|root,COG3437@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4936@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,267DC@186807|Peptococcaceae	186801|Clostridia	T	Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,PAS,PocR,SBP_bac_3
k59_122660_1	56780.SYN_02978	1.06e-59	192.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,42PCG@68525|delta/epsilon subdivisions,2WM8X@28221|Deltaproteobacteria,2MR9H@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_278811_1	102232.GLO73106DRAFT_00033450	2.36e-78	244.0	COG2089@1|root,COG2089@2|Bacteria,1G78N@1117|Cyanobacteria	1117|Cyanobacteria	M	synthase	spsE	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
k59_25032_1	323848.Nmul_A1845	1.05e-84	254.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2VQUX@28216|Betaproteobacteria,372TE@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
k59_25032_2	1266925.JHVX01000009_gene53	7.31e-39	140.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VJ6T@28216|Betaproteobacteria,372WA@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3501
k59_644613_1	1485544.JQKP01000012_gene2106	1.37e-97	302.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,44V4W@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_382561_1	1121405.dsmv_1965	3.38e-12	65.1	COG0589@1|root,COG0589@2|Bacteria,1PEB7@1224|Proteobacteria,42XVC@68525|delta/epsilon subdivisions,2WSNF@28221|Deltaproteobacteria,2MMDT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_382566_1	1033802.SSPSH_000373	2.64e-72	236.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2015 Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_536334_1	990285.RGCCGE502_14780	4.26e-51	178.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,4B9EB@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase,Sulfatase_C
k59_678483_1	391615.ABSJ01000026_gene110	1.37e-22	98.6	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1J6A4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	PT	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_711270_2	1090320.KB900608_gene239	1.12e-141	419.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,2K06B@204457|Sphingomonadales	204457|Sphingomonadales	P	chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_743677_1	580332.Slit_0368	1.27e-82	268.0	COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,2VHXY@28216|Betaproteobacteria,44WBH@713636|Nitrosomonadales	28216|Betaproteobacteria	S	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
k59_122690_1	887062.HGR_13039	1.19e-90	275.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,4AC49@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_939482_1	1254432.SCE1572_09930	6.33e-06	54.7	COG4677@1|root,COG4677@2|Bacteria,1PXT2@1224|Proteobacteria,434TW@68525|delta/epsilon subdivisions,2WZ4T@28221|Deltaproteobacteria,2Z1BV@29|Myxococcales	28221|Deltaproteobacteria	G	pectinesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	NosD
k59_382591_1	556268.OFAG_01661	4.82e-57	191.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,472HN@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_382591_2	472759.Nhal_3277	3.81e-08	52.8	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1WYUC@135613|Chromatiales	135613|Chromatiales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
k59_187447_1	436308.Nmar_1753	4.72e-77	244.0	arCOG08764@1|root,arCOG08764@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_278832_1	1150469.RSPPHO_00775	1.87e-74	244.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2U0PD@28211|Alphaproteobacteria,2JPZE@204441|Rhodospirillales	204441|Rhodospirillales	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HD_5
k59_249300_1	269482.Bcep1808_4568	7.05e-25	102.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1,HTH_Tnp_IS630
k59_249302_1	1110502.TMO_0510	8.09e-21	91.3	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2TSAC@28211|Alphaproteobacteria,2JPB4@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, middle domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_249302_2	748247.AZKH_3413	1.85e-47	165.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_122722_1	883.DvMF_2681	6.31e-25	107.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,42MBW@68525|delta/epsilon subdivisions,2WK2Z@28221|Deltaproteobacteria,2M972@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	TIGRFAM ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
k59_25097_1	292415.Tbd_2635	4.85e-49	168.0	COG0494@1|root,COG0494@2|Bacteria,1MYSK@1224|Proteobacteria,2W3WC@28216|Betaproteobacteria	28216|Betaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_644677_1	883078.HMPREF9695_00818	1.49e-52	177.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TRVU@28211|Alphaproteobacteria,3JVDQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_678529_1	420662.Mpe_A1955	1.81e-10	60.5	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,1KJR8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_350980_1	179408.Osc7112_2700	7.81e-39	148.0	COG0642@1|root,COG0784@1|root,COG2199@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1GBMR@1117|Cyanobacteria,1HER3@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c,HisKA,Response_reg
k59_743722_1	1121931.AUHG01000010_gene523	4.63e-11	60.8	2E77J@1|root,331RB@2|Bacteria,4NW0U@976|Bacteroidetes,1I5GK@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_580371_1	35703.DQ02_00790	2.44e-106	330.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,3WVNJ@544|Citrobacter	1236|Gammaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_2673	ACT_4,HD_4,RelA_SpoT,TGS
k59_122733_2	323848.Nmul_A0604	5.77e-29	107.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,3738S@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Nudix hydrolase	ntpA	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
k59_155486_1	1047013.AQSP01000115_gene356	6.65e-51	182.0	COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase	aspB	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297	2.6.1.1,2.6.1.14	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052	RC00006,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
k59_155486_2	330214.NIDE2568	5.58e-26	98.6	COG2331@1|root,COG2331@2|Bacteria,3J0V8@40117|Nitrospirae	40117|Nitrospirae	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_249328_1	395493.BegalDRAFT_2678	2.1e-73	244.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,45ZVF@72273|Thiotrichales	72273|Thiotrichales	NU	Type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_939542_1	945713.IALB_2703	6.55e-73	234.0	COG3303@1|root,COG4412@1|root,COG3303@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552,Cytochrome_C554,DUF4859,Paired_CXXCH_1
k59_580391_1	864051.BurJ1DRAFT_0383	8.04e-96	282.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2VQ4W@28216|Betaproteobacteria,1KJY4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_187497_1	1123229.AUBC01000024_gene4585	2.33e-56	198.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JQVN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	MA20_27485	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_904594_1	1057002.KB905370_gene4587	8.56e-23	99.8	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2V7KJ@28211|Alphaproteobacteria,4BJYD@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_90729_1	330214.NIDE3220	4.2e-133	383.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	rhdA	-	2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_123675_1	292415.Tbd_2456	5.68e-98	294.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,1KRF9@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_478425_1	1122212.AULO01000007_gene2499	5.79e-92	280.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1XI4A@135619|Oceanospirillales	135619|Oceanospirillales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_712298_1	1131553.JIBI01000065_gene1017	8.17e-98	304.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VI60@28216|Betaproteobacteria,37330@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Gamma-glutamyltranspeptidase	acyI	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_744731_1	395494.Galf_1437	0.000659	47.8	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,44W46@713636|Nitrosomonadales	28216|Betaproteobacteria	Q	Hemolysin-type calcium-binding region	cyaA	GO:0001906,GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005576,GO:0006873,GO:0006874,GO:0006875,GO:0007204,GO:0008150,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0019725,GO:0019835,GO:0030003,GO:0031640,GO:0035821,GO:0042592,GO:0044179,GO:0044364,GO:0044419,GO:0044764,GO:0048878,GO:0050801,GO:0051480,GO:0051704,GO:0051715,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0072503,GO:0072507,GO:0098771	4.6.1.1	ko:K11005,ko:K11029	ko00230,ko05133,map00230,map05133	M00575	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02000,ko02042	1.C.11	-	-	Anthrax_toxA,DUF4214,HCBP_related,He_PIG,HemolysinCabind,RTX
k59_26071_1	330214.NIDE1728	1.51e-80	258.0	COG0443@1|root,COG0443@2|Bacteria,3J0D2@40117|Nitrospirae	40117|Nitrospirae	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_123679_1	765911.Thivi_3327	9.59e-16	74.3	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1WW0F@135613|Chromatiales	135613|Chromatiales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_123679_2	546274.EIKCOROL_01906	1.03e-43	155.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,2KPIX@206351|Neisseriales	206351|Neisseriales	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_26072_1	138119.DSY0316	6.29e-94	286.0	COG5557@1|root,COG5557@2|Bacteria,1UYGM@1239|Firmicutes,24EQA@186801|Clostridia,263KI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_57768_1	93220.LV28_00775	1.5e-89	287.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,1K41J@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1004220_1	269799.Gmet_0648	2.73e-34	125.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,43TK4@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1004220_2	673862.BABL1_528	9.58e-11	59.3	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions	1224|Proteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_26077_1	765912.Thimo_2864	1.17e-50	164.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1WWE7@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_26081_1	1121861.KB899922_gene3120	2.15e-51	181.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria,2JPWJ@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_351978_1	717774.Marme_2057	2.56e-118	354.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1XIWI@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_317396_1	1502851.FG93_04796	5.06e-33	123.0	COG0400@1|root,COG0400@2|Bacteria,1MUKQ@1224|Proteobacteria,2TUA0@28211|Alphaproteobacteria,3JTR9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_2
k59_156449_1	283942.IL1965	8.48e-07	50.1	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2QFKA@267893|Idiomarinaceae	1236|Gammaproteobacteria	U	General secretion pathway	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1,T2SSB
k59_679550_1	436308.Nmar_1261	2.23e-112	333.0	COG0621@1|root,arCOG01358@2157|Archaea,41SB9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	MiaB-like tRNA modifying enzyme	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
k59_413516_2	243233.MCA2858	7.49e-156	444.0	COG2037@1|root,COG2037@2|Bacteria,1MVSD@1224|Proteobacteria,1S0G2@1236|Gammaproteobacteria,1XGY9@135618|Methylococcales	135618|Methylococcales	H	Formylmethanofuran-tetrahydromethanopterin formyltransferase	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0030270,GO:0043446,GO:0044237,GO:0071704	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
k59_536874_1	1454004.AW11_02798	5.55e-90	283.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria,1KR83@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_390559_1	171693.BN988_03207	1.3e-47	164.0	COG0803@1|root,COG0803@2|Bacteria,1TRKU@1239|Firmicutes,4HAKT@91061|Bacilli,23K1U@182709|Oceanobacillus	91061|Bacilli	P	Zinc-uptake complex component A periplasmic	troA	-	-	ko:K11707	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ZnuA
k59_227704_1	572477.Alvin_2188	7.92e-24	100.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_227704_2	5334.XP_003038078.1	1.28e-11	65.5	COG2867@1|root,KOG3177@2759|Eukaryota,39KQW@33154|Opisthokonta,3P5BB@4751|Fungi,3V20Q@5204|Basidiomycota,229G9@155619|Agaricomycetes,3W81S@5338|Agaricales	4751|Fungi	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
k59_620109_1	246197.MXAN_2513	1.72e-76	247.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YUKY@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_256209_1	1121405.dsmv_2653	2.56e-93	288.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,42RGI@68525|delta/epsilon subdivisions,2WNGP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_33
k59_795518_1	391038.Bphy_4249	1.3e-46	162.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,1K17R@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_455936_1	883078.HMPREF9695_03089	2.6e-54	187.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1QXEH@1224|Proteobacteria,2TX96@28211|Alphaproteobacteria,3K6W1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IT	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,FHA,Guanylate_cyc
k59_227718_1	883080.HMPREF9697_01684	1.84e-109	333.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,3JUBU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	MA20_34330	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_323862_1	1489678.RDMS_03925	6.58e-08	55.1	2DNS7@1|root,32YWC@2|Bacteria,1WKTD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_455944_1	1288494.EBAPG3_8860	2.56e-40	142.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria,371TG@32003|Nitrosomonadales	28216|Betaproteobacteria	H	uroporphyrinogen III synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_419592_2	1485544.JQKP01000003_gene224	1.39e-29	108.0	COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,2VWKA@28216|Betaproteobacteria,44WMD@713636|Nitrosomonadales	28216|Betaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_227723_1	1123367.C666_08615	3.29e-85	264.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,2KVC9@206389|Rhodocyclales	206389|Rhodocyclales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_912178_1	83406.HDN1F_20010	3.88e-77	237.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1J4P1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_419600_1	311402.Avi_5380	2.24e-05	46.2	COG3535@1|root,COG3535@2|Bacteria,1NCBV@1224|Proteobacteria,2TU70@28211|Alphaproteobacteria,4BBA3@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF917)	-	-	-	ko:K09703	-	-	-	-	ko00000	-	-	-	DUF917
k59_419600_2	264732.Moth_0211	1.19e-55	185.0	arCOG05881@1|root,2Z800@2|Bacteria,1TS9C@1239|Firmicutes,24CDW@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1177
k59_540495_1	398578.Daci_3072	9.54e-49	172.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,2VHKW@28216|Betaproteobacteria,4ACF9@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_390622_2	1265502.KB905933_gene2118	1.34e-34	135.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,4AC5G@80864|Comamonadaceae	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_880719_1	211114.JOEF01000035_gene1572	8.73e-05	50.4	COG0477@1|root,COG2814@2|Bacteria,2I2PQ@201174|Actinobacteria,4EDWF@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_880723_1	572480.Arnit_0211	3.65e-61	201.0	COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,42PX0@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	gpgS	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
k59_390635_2	1286631.X805_18000	1.08e-24	94.0	2EGTE@1|root,33AJI@2|Bacteria,1N5DW@1224|Proteobacteria,2VUCZ@28216|Betaproteobacteria,1KMN4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of Unknown Function (DUF350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
k59_323924_1	1382304.JNIL01000001_gene520	2.49e-19	88.2	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,4HAVW@91061|Bacilli,277YU@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_323924_2	1123376.AUIU01000003_gene1636	0.000452	43.1	COG0825@1|root,COG0825@2|Bacteria,3J0CN@40117|Nitrospirae	40117|Nitrospirae	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
k59_484337_2	945713.IALB_0421	6.56e-43	149.0	COG1294@1|root,COG1294@2|Bacteria	2|Bacteria	C	oxidative phosphorylation	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120	Cyt_bd_oxida_II
k59_456002_2	398578.Daci_0844	5.11e-09	58.9	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2VR0Y@28216|Betaproteobacteria,4ACMC@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the ompA family	yiaD_1	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
k59_540517_1	330214.NIDE3513	9.17e-126	365.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_195511_1	640081.Dsui_1125	2.25e-125	370.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2VHK0@28216|Betaproteobacteria,2KUE4@206389|Rhodocyclales	206389|Rhodocyclales	G	Malonyl-CoA decarboxylase N-terminal domain	-	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
k59_195515_1	977880.RALTA_A2566	6.12e-11	63.2	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI85@28216|Betaproteobacteria,1K241@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	dld	-	1.1.2.4,1.1.5.12	ko:K00102,ko:K03777	ko00620,ko01120,map00620,map01120	-	R00197,R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_195515_2	381666.H16_B0689	2.76e-27	100.0	2E7PS@1|root,3325B@2|Bacteria,1PVAH@1224|Proteobacteria,2VVUK@28216|Betaproteobacteria,1KAP4@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_795554_1	1000565.METUNv1_04058	3.75e-116	361.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,2KU82@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_227824_1	583345.Mmol_1936	1.93e-08	52.4	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,2KN55@206350|Nitrosomonadales	206350|Nitrosomonadales	U	TIGRFAM preprotein translocase, YajC subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_227824_2	640081.Dsui_3325	3.13e-42	154.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,2KV11@206389|Rhodocyclales	206389|Rhodocyclales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_778902_2	1274374.CBLK010000085_gene4625	1.9e-24	95.1	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,4HGX6@91061|Bacilli,26XFY@186822|Paenibacillaceae	91061|Bacilli	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_1028238_1	501479.ACNW01000050_gene3484	7.51e-32	123.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_778910_1	1410638.JHXJ01000003_gene1500	7.64e-25	107.0	COG0580@1|root,COG3859@1|root,COG0580@2|Bacteria,COG3859@2|Bacteria,1TP4T@1239|Firmicutes,248U5@186801|Clostridia,3WGG8@541000|Ruminococcaceae	186801|Clostridia	G	Major intrinsic protein	-	-	-	ko:K02440,ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2	-	-	MIP
k59_1028241_1	883126.HMPREF9710_03830	6.06e-08	52.8	COG0664@1|root,COG0664@2|Bacteria,1R64V@1224|Proteobacteria,2VJXN@28216|Betaproteobacteria,472QZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_1028241_2	883078.HMPREF9695_03112	8.01e-60	199.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_15125	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_456044_1	240016.ABIZ01000001_gene3549	9.21e-84	262.0	COG0577@1|root,COG0577@2|Bacteria,46UQN@74201|Verrucomicrobia,2IVBP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_323991_1	754436.JCM19237_5406	2.95e-37	135.0	COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria,1S2SV@1236|Gammaproteobacteria,1XT2Q@135623|Vibrionales	135623|Vibrionales	S	(twin-arginine translocation) pathway signal	VPA0371	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_227849_1	497321.C664_12015	5.15e-46	160.0	COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria,2WGTA@28216|Betaproteobacteria,2KZWK@206389|Rhodocyclales	206389|Rhodocyclales	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_227849_2	1288494.EBAPG3_7180	6.46e-155	473.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,372NK@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_778926_1	315749.Bcer98_3225	1.41e-40	143.0	COG1309@1|root,COG1309@2|Bacteria,1TRSH@1239|Firmicutes,4H9RC@91061|Bacilli,1ZAU5@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	fadR	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K13770	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
k59_1028250_1	671143.DAMO_0860	4.03e-13	73.6	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	glnG	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07712,ko:K07714	ko02020,map02020	M00497,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_781633_2	202954.BBNK01000034_gene3794	1.97e-25	99.4	2A3Q7@1|root,30S7S@2|Bacteria,1NP2K@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_543182_1	640081.Dsui_1401	6.1e-60	193.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,2KW45@206389|Rhodocyclales	206389|Rhodocyclales	M	VacJ family lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_258868_1	330214.NIDE3730	2.91e-18	84.3	COG0612@1|root,COG0612@2|Bacteria,3J0I5@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_258868_2	330214.NIDE3729	1.85e-249	694.0	COG0612@1|root,COG0612@2|Bacteria,3J0BY@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_543197_1	1125699.HMPREF9194_00117	5.4e-31	112.0	COG1970@1|root,COG1970@2|Bacteria,2J7XF@203691|Spirochaetes	203691|Spirochaetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_543197_2	931276.Cspa_c56130	7.5e-16	76.6	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36DZS@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_486885_1	936136.ARRT01000007_gene1333	1.22e-19	85.5	COG0625@1|root,COG0625@2|Bacteria,1N8XH@1224|Proteobacteria,2TTHQ@28211|Alphaproteobacteria,4BBIZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	MA20_08585	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3
k59_422432_1	381666.H16_A0466	5.2e-66	221.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,1K0VC@119060|Burkholderiaceae	28216|Betaproteobacteria	V	abc transporter	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_422432_2	1163617.SCD_n00667	2.11e-93	286.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria	28216|Betaproteobacteria	I	phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsB	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_1029719_1	1123354.AUDR01000014_gene886	7.6e-89	272.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,1KS8U@119069|Hydrogenophilales	119069|Hydrogenophilales	J	S4 RNA-binding domain	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_422470_1	398525.KB900701_gene516	8.25e-79	246.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3JX5H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_486960_1	1120977.JHUX01000003_gene1696	1.34e-15	76.3	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,3NJ8A@468|Moraxellaceae	1236|Gammaproteobacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_486960_2	1089552.KI911559_gene965	6.25e-61	206.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2JQYE@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_258956_1	1089552.KI911559_gene352	3.82e-107	334.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,2JQAA@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_487007_2	1348657.M622_00350	2.36e-62	203.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,2KUUQ@206389|Rhodocyclales	206389|Rhodocyclales	U	Involved in the tonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_422547_1	911045.PSE_p0146	6.62e-82	262.0	COG3385@1|root,COG3385@2|Bacteria,1RCTP@1224|Proteobacteria,2UPV7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_258984_1	1229909.NSED_09745	1.02e-29	116.0	COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_258984_2	1229909.NSED_09735	1.85e-33	118.0	arCOG08804@1|root,arCOG08804@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_258989_1	1229909.NSED_09305	4.17e-98	295.0	COG0399@1|root,arCOG00118@2157|Archaea,41S96@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_543352_2	1348657.M622_05860	2.88e-53	173.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2VHBM@28216|Betaproteobacteria,2KUUC@206389|Rhodocyclales	206389|Rhodocyclales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_781797_1	977880.RALTA_B0210	9.55e-53	178.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6UF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_284701_1	261292.Nit79A3_0451	1.3e-110	333.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,371PC@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
k59_781817_1	404589.Anae109_3035	6.45e-54	193.0	COG2373@1|root,COG3227@1|root,COG4412@1|root,COG2373@2|Bacteria,COG3227@2|Bacteria,COG4412@2|Bacteria,1MWWV@1224|Proteobacteria,42S3D@68525|delta/epsilon subdivisions,2WNYK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Large extracellular alpha-helical protein	-	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C13
k59_487097_1	1286106.MPL1_12191	1.06e-28	107.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,460SP@72273|Thiotrichales	72273|Thiotrichales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_487097_2	1123393.KB891332_gene2797	1.17e-36	124.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,1KRWR@119069|Hydrogenophilales	119069|Hydrogenophilales	C	ATP synthase subunit C	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_543391_1	710686.Mycsm_00730	1.56e-47	165.0	COG1052@1|root,COG1052@2|Bacteria,2HBNQ@201174|Actinobacteria,2346H@1762|Mycobacteriaceae	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_543393_1	1479235.KK366039_gene1869	8.97e-33	122.0	COG2801@1|root,COG2801@2|Bacteria,1R6QN@1224|Proteobacteria,1S7GS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve,rve_3
k59_781839_1	880073.Calab_3530	6.96e-73	233.0	COG1004@1|root,COG1004@2|Bacteria,2NNYN@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_284716_1	1121405.dsmv_3296	1.46e-164	474.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MIPI@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM carboxyl transferase	pccB	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_543402_1	1235457.C404_08220	2.44e-65	212.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,1K0WM@119060|Burkholderiaceae	28216|Betaproteobacteria	M	(Lipo)protein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_422661_1	42565.FP66_05580	3.6e-96	295.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_487151_2	46429.BV95_00894	3.83e-84	254.0	COG1961@1|root,COG1961@2|Bacteria,1MXXT@1224|Proteobacteria,2U9WZ@28211|Alphaproteobacteria,2K3Q6@204457|Sphingomonadales	204457|Sphingomonadales	L	resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
k59_487151_3	880073.Calab_0749	6.44e-23	92.0	2CG0S@1|root,33AN9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_422697_1	330214.NIDE3711	1.67e-82	255.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1029813_1	1191523.MROS_0021	2.54e-94	287.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1,PTR2
k59_1029813_2	945713.IALB_2752	7.04e-07	50.1	COG0482@1|root,COG0482@2|Bacteria	2|Bacteria	J	sulfurtransferase activity	mnmA	GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1029818_1	1229909.NSED_01340	7.64e-12	63.2	COG5424@1|root,arCOG06031@2157|Archaea,41SJK@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_1029818_2	436308.Nmar_0287	1.63e-41	143.0	COG0142@1|root,arCOG01727@2157|Archaea,41SC6@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_259133_1	765910.MARPU_09265	1.33e-33	127.0	COG1524@1|root,COG1524@2|Bacteria,1R2II@1224|Proteobacteria,1RQDZ@1236|Gammaproteobacteria,1X2CP@135613|Chromatiales	135613|Chromatiales	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_855394_1	543728.Vapar_5684	1.66e-27	103.0	COG5569@1|root,COG5569@2|Bacteria,1N8CJ@1224|Proteobacteria,2VVSU@28216|Betaproteobacteria,4AFSA@80864|Comamonadaceae	28216|Betaproteobacteria	S	Copper binding periplasmic protein CusF	cusF	-	-	-	-	-	-	-	-	-	-	-	CusF_Ec
k59_855394_2	204773.HEAR1583	6.92e-42	141.0	COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,2VSDP@28216|Betaproteobacteria,474YT@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,CusF_Ec
k59_562086_1	1288494.EBAPG3_4020	2.43e-112	331.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,371T3@32003|Nitrosomonadales	28216|Betaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_39504_1	204669.Acid345_2313	1.37e-28	113.0	2AZDP@1|root,31RMA@2|Bacteria,3Y4JB@57723|Acidobacteria,2JJ76@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
k59_692731_1	76114.ebA3623	1.52e-70	226.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2VHD1@28216|Betaproteobacteria,2KVBD@206389|Rhodocyclales	206389|Rhodocyclales	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_594572_1	445684.E3SQ80_9CAUD	1.52e-50	184.0	4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses  no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae	10662|Myoviridae	S	Phage tail sheath protein	-	GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027	-	-	-	-	-	-	-	-	-	-	-
k59_725242_1	1049564.TevJSym_al00200	1.68e-73	237.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
k59_496879_1	290402.Cbei_2039	1.12e-09	62.8	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
k59_170192_1	1288494.EBAPG3_26320	2.99e-66	226.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	AMP-dependent synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_170192_2	1007105.PT7_2782	1.21e-19	88.6	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VHFS@28216|Betaproteobacteria,3T37Y@506|Alcaligenaceae	28216|Betaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	gltI	-	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_660162_1	32049.SYNPCC7002_A2814	3.05e-80	250.0	COG2084@1|root,COG2084@2|Bacteria,1G34X@1117|Cyanobacteria,1GYS7@1129|Synechococcus	1117|Cyanobacteria	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases	mmsB	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_430972_1	1288494.EBAPG3_31040	2.78e-74	225.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VRJ0@28216|Betaproteobacteria,374MK@32003|Nitrosomonadales	28216|Betaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
k59_430972_2	1144343.PMI41_00512	1.81e-31	113.0	COG3832@1|root,COG3832@2|Bacteria,1RD0P@1224|Proteobacteria,2U79U@28211|Alphaproteobacteria,43RFS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Activator of Hsp90	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_496899_1	243159.AFE_2692	1.83e-18	90.1	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,2NDXJ@225057|Acidithiobacillales	225057|Acidithiobacillales	M	type I secretion membrane fusion protein, HlyD family	-	-	-	ko:K11003	ko03070,ko05133,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	8.A.1.3.1,8.A.1.3.2	-	-	Biotin_lipoyl_2,HlyD_3
k59_594605_1	323097.Nham_3769	7.18e-38	137.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_985945_1	395495.Lcho_0061	1.04e-50	173.0	COG2143@1|root,COG2143@2|Bacteria,1RB3S@1224|Proteobacteria,2VX2X@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Thioredoxin-like	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	Thioredoxin_2
k59_627114_1	880073.Calab_1196	4.95e-18	88.6	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_660182_1	76114.ebA4808	1.22e-65	217.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,2KUDS@206389|Rhodocyclales	206389|Rhodocyclales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_985951_1	640081.Dsui_0666	5.41e-82	258.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,2KUVM@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_887793_1	517417.Cpar_1684	2.99e-81	249.0	COG1741@1|root,COG1741@2|Bacteria,1FEUN@1090|Chlorobi	1090|Chlorobi	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_72484_1	1267535.KB906767_gene425	1.25e-67	228.0	COG1048@1|root,COG1048@2|Bacteria,3Y34Q@57723|Acidobacteria,2JHMV@204432|Acidobacteriia	204432|Acidobacteriia	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_300289_1	96561.Dole_3028	1.21e-48	160.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,42SJS@68525|delta/epsilon subdivisions,2WP7N@28221|Deltaproteobacteria,2MK9P@213118|Desulfobacterales	28221|Deltaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_170937_1	585.DR95_1485	2.71e-29	119.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,1RS1P@1236|Gammaproteobacteria,3Z2C0@583|Proteus	1236|Gammaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_73231_1	365046.Rta_18760	5.13e-36	136.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2VKCH@28216|Betaproteobacteria,4A9VW@80864|Comamonadaceae	28216|Betaproteobacteria	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
k59_73231_2	1266925.JHVX01000003_gene449	2.74e-12	66.6	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,372IA@32003|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter transmembrane region	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_138350_1	661367.LLO_3249	1.45e-20	94.4	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,1RP9M@1236|Gammaproteobacteria,1JFJI@118969|Legionellales	118969|Legionellales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_138350_2	1040989.AWZU01000008_gene3776	2.71e-32	123.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2U0D0@28211|Alphaproteobacteria,3JURI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_366444_1	314287.GB2207_11293	2.21e-51	180.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,1SYJ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_595348_1	522306.CAP2UW1_2263	4.62e-137	402.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,1KPR6@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_595348_2	1288494.EBAPG3_25730	5.33e-267	740.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,372PF@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Large family of predicted nucleotide-binding domains	phoH	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_824149_1	1469245.JFBG01000077_gene321	4.27e-135	396.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_888499_1	228410.NE0405	4.97e-46	149.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2VSGE@28216|Betaproteobacteria,373AS@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_888499_2	795666.MW7_3221	3.05e-87	264.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,1K0IX@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_7834_1	1123371.ATXH01000004_gene1695	6.54e-08	53.1	COG0060@1|root,COG0060@2|Bacteria,2GGVX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_7834_2	32057.KB217478_gene5852	1.62e-42	148.0	COG1209@1|root,COG1209@2|Bacteria,1G091@1117|Cyanobacteria,1HJMN@1161|Nostocales	1117|Cyanobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_527842_1	85643.Tmz1t_2656	1.1e-78	243.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,2KVFV@206389|Rhodocyclales	206389|Rhodocyclales	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_73252_1	318996.AXAZ01000077_gene1675	3.34e-16	83.2	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,3JR5W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_9,Pkinase
k59_203440_1	1266925.JHVX01000002_gene869	8.35e-77	251.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,371VX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_660941_1	1121405.dsmv_2535	4.42e-16	80.9	COG0683@1|root,COG0683@2|Bacteria,1MYGR@1224|Proteobacteria,42YJT@68525|delta/epsilon subdivisions,2WU23@28221|Deltaproteobacteria,2MN85@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_627877_1	314285.KT71_08350	1.01e-23	99.4	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1J5G2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon2	-	3.4.21.53	ko:K01338,ko:K08675	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03029	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_627877_2	247634.GPB2148_2623	6.04e-50	168.0	COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,1RMQY@1236|Gammaproteobacteria,1J57X@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs	cmoB	GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016740,GO:0016741,GO:0016765,GO:0022607,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_9
k59_463172_1	1120983.KB894571_gene2324	5.78e-08	57.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,1JNTV@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_824170_1	1040989.AWZU01000028_gene2940	4.17e-65	207.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,3JS5I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	MA20_25935	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_824170_2	1349767.GJA_511	6.24e-05	44.7	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,4727A@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_627878_1	655815.ZPR_2487	1.3e-21	99.4	COG0745@1|root,COG2207@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2207@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,1HZEZ@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_888511_2	391038.Bphy_4169	8.76e-08	50.8	2AGR6@1|root,317J0@2|Bacteria,1PYW5@1224|Proteobacteria,2WE0S@28216|Betaproteobacteria,1KBDC@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_431737_1	96561.Dole_2815	7.54e-47	166.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MHQQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_203454_2	391008.Smal_0710	3.01e-10	58.5	COG0640@1|root,COG0640@2|Bacteria,1QVFX@1224|Proteobacteria	1224|Proteobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
k59_726080_1	472759.Nhal_1290	3.14e-78	260.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_824175_1	1168034.FH5T_19015	3e-77	246.0	COG0644@1|root,COG0644@2|Bacteria,4P040@976|Bacteroidetes	976|Bacteroidetes	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_693596_2	228410.NE0010	4.05e-119	361.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,371XW@32003|Nitrosomonadales	28216|Betaproteobacteria	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_756980_1	330214.NIDE2491	3.81e-99	294.0	28MYQ@1|root,2ZB5K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_497708_1	305700.B447_00655	1.67e-76	240.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHGM@28216|Betaproteobacteria,2KVQ7@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_268880_1	1123072.AUDH01000019_gene2222	8.45e-33	119.0	COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TXAJ@28211|Alphaproteobacteria,2JWX2@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
k59_268880_2	1038859.AXAU01000006_gene5613	9.11e-44	148.0	COG4032@1|root,COG4032@2|Bacteria,1P0HU@1224|Proteobacteria,2TRJ2@28211|Alphaproteobacteria,3JQMU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	MA20_16825	-	4.1.1.79	ko:K06034	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
k59_922086_1	314345.SPV1_02292	1.96e-20	90.9	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria	1224|Proteobacteria	P	flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like,Pyr_redox_3
k59_922086_2	1120965.AUBV01000005_gene1570	3.42e-06	49.7	COG2133@1|root,COG2133@2|Bacteria,4PN3W@976|Bacteroidetes,47Y98@768503|Cytophagia	976|Bacteroidetes	G	A domain in the BMP inhibitor chordin and in microbial proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
k59_922094_1	754476.Q7A_2480	2.08e-71	238.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,45ZUW@72273|Thiotrichales	72273|Thiotrichales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_824197_2	1463857.JOFZ01000006_gene3441	4.02e-13	65.5	2DWP5@1|root,3419M@2|Bacteria,2IPG7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_398066_1	1185876.BN8_02234	1.99e-27	118.0	COG0627@1|root,COG0627@2|Bacteria,4NIU8@976|Bacteroidetes,47NUH@768503|Cytophagia	976|Bacteroidetes	E	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_73289_2	177437.HRM2_15150	2.19e-55	186.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,2MMPY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	moz	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
k59_105699_1	1121943.KB899989_gene3196	1.6e-22	101.0	COG3276@1|root,COG3276@2|Bacteria,1QYU8@1224|Proteobacteria,1T3UU@1236|Gammaproteobacteria,1XRZI@135619|Oceanospirillales	135619|Oceanospirillales	J	Elongation factor SelB, winged helix	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_627915_1	614083.AWQR01000033_gene2875	1.18e-93	286.0	COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,2VHAD@28216|Betaproteobacteria,4ABD4@80864|Comamonadaceae	28216|Betaproteobacteria	EG	Drug metabolite transporter	cnrT	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_171011_1	525897.Dbac_1405	1.2e-98	307.0	COG0410@1|root,COG1541@1|root,COG0410@2|Bacteria,COG1541@2|Bacteria,1MXF5@1224|Proteobacteria,42MZA@68525|delta/epsilon subdivisions,2WIUC@28221|Deltaproteobacteria,2M8S0@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-3	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_301020_1	1123377.AUIV01000014_gene458	2.13e-46	165.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1X5AR@135614|Xanthomonadales	135614|Xanthomonadales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_726122_1	1101195.Meth11DRAFT_1563	4.48e-124	364.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,2KKW1@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_268922_1	1125863.JAFN01000001_gene1612	3.17e-43	148.0	COG1418@1|root,COG1418@2|Bacteria,1RJ5H@1224|Proteobacteria,42SFF@68525|delta/epsilon subdivisions,2WP85@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	metal-dependent phosphohydrolase HD	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_888555_1	945713.IALB_1909	3.98e-136	393.0	COG2255@1|root,COG2255@2|Bacteria	2|Bacteria	L	four-way junction helicase activity	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_40349_2	644801.Psest_3735	3.42e-08	57.0	COG2050@1|root,COG2050@2|Bacteria,1N5HF@1224|Proteobacteria,1RNAK@1236|Gammaproteobacteria,1Z22J@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	yigI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	4HBT
k59_531426_1	1163617.SCD_n02131	1.32e-73	246.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_177799_1	1288494.EBAPG3_30060	3.06e-133	385.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,372HG@32003|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_112570_1	471854.Dfer_2426	1.55e-47	164.0	COG3386@1|root,COG3386@2|Bacteria,4NIMX@976|Bacteroidetes,47KMQ@768503|Cytophagia	976|Bacteroidetes	G	PFAM SMP-30 Gluconolaconase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_112570_2	404589.Anae109_4242	1.62e-61	209.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales	28221|Deltaproteobacteria	K	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat
k59_403785_2	640511.BC1002_5941	4.22e-172	491.0	COG0508@1|root,COG0508@2|Bacteria,1MVDC@1224|Proteobacteria,2VPEK@28216|Betaproteobacteria,1K0K3@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_403785_3	1037409.BJ6T_23800	2.79e-31	115.0	COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,2U0MC@28211|Alphaproteobacteria,3JTRU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
k59_504645_1	1231391.AMZF01000025_gene1373	3.44e-71	223.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2VHC8@28216|Betaproteobacteria,3T1PM@506|Alcaligenaceae	28216|Betaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_993368_1	1298608.JCM18900_12	9.17e-05	49.7	COG1403@1|root,COG1403@2|Bacteria,1NMK8@1224|Proteobacteria	1224|Proteobacteria	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_569895_1	930169.B5T_01627	4.02e-23	95.9	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,1RQXB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	gluconolactonase	gnl	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_569895_2	357804.Ping_1235	4.43e-28	112.0	COG0754@1|root,COG3942@1|root,COG0754@2|Bacteria,COG3942@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Glutathionylspermidine synthase	gsp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008884,GO:0008885,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016880,GO:0044424,GO:0044444,GO:0044464	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3484	CHAP,GSP_synth
k59_701768_2	391735.Veis_4204	7.18e-10	59.7	COG3181@1|root,COG3181@2|Bacteria,1R4PJ@1224|Proteobacteria,2VNY9@28216|Betaproteobacteria,4ACK2@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_668941_1	314230.DSM3645_29476	6e-55	185.0	COG2768@1|root,COG2768@2|Bacteria,2IXTH@203682|Planctomycetes	203682|Planctomycetes	C	conserved protein (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_763512_1	485913.Krac_2433	2.58e-47	157.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_763512_2	272558.10176345	6.15e-24	94.4	COG2337@1|root,COG2337@2|Bacteria,1VBXM@1239|Firmicutes,4HM83@91061|Bacilli,1ZHVH@1386|Bacillus	91061|Bacilli	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
k59_962615_1	543632.JOJL01000121_gene9849	8.39e-74	235.0	COG1321@1|root,COG1321@2|Bacteria,2GN2R@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_863778_1	365044.Pnap_3985	4.51e-62	197.0	COG3963@1|root,COG3963@2|Bacteria,1N1KB@1224|Proteobacteria,2VTPN@28216|Betaproteobacteria,4AEPX@80864|Comamonadaceae	28216|Betaproteobacteria	I	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_113498_1	1158756.AQXQ01000009_gene1190	4.45e-40	149.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1WX4U@135613|Chromatiales	135613|Chromatiales	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD_5
k59_701777_1	67267.JNXT01000065_gene528	2.29e-37	141.0	COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_241262_1	1121405.dsmv_2103	3.64e-39	150.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_962624_2	398578.Daci_2530	0.000194	44.3	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQ9@28216|Betaproteobacteria,4AAAF@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
k59_113505_1	945713.IALB_1905	2.55e-98	305.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_241263_1	1121403.AUCV01000088_gene2976	2.93e-15	76.3	COG0703@1|root,COG0703@2|Bacteria,1P4F5@1224|Proteobacteria,433KK@68525|delta/epsilon subdivisions,2WY9G@28221|Deltaproteobacteria,2MP7E@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_15849_1	404589.Anae109_4219	1.08e-23	106.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_505609_1	671143.DAMO_2947	8.6e-88	271.0	COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria	2|Bacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_763528_1	1502851.FG93_02357	2.51e-100	298.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,3JXQY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	dppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_763528_2	460265.Mnod_0487	6.59e-48	162.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,1JR8B@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EP	Belongs to the ABC transporter superfamily	dppD	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678	-	ko:K12371	ko02010,map02010	M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_48054_1	1298867.AUES01000007_gene5083	6.23e-44	158.0	COG0165@1|root,COG0165@2|Bacteria,1MX0X@1224|Proteobacteria,2U2F3@28211|Alphaproteobacteria,3JW1S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Argininosuccinate lyase C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	ASL_C2,Lyase_1
k59_570885_1	1123487.KB892857_gene2536	2.19e-81	265.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA topoisomerase III	-	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
k59_635618_1	391625.PPSIR1_35557	9.74e-30	123.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WTUX@28221|Deltaproteobacteria,2YTTM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_373991_1	1229909.NSED_01605	8.33e-63	201.0	arCOG08038@1|root,arCOG10597@1|root,arCOG08038@2157|Archaea,arCOG10597@2157|Archaea,41SZN@651137|Thaumarchaeota	651137|Thaumarchaeota	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_439274_1	257310.BB0233	9.64e-94	293.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,3T1XK@506|Alcaligenaceae	28216|Betaproteobacteria	I	Long-chain acyl-CoA synthetases (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_274212_1	572477.Alvin_1555	1.14e-37	139.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1WYC8@135613|Chromatiales	135613|Chromatiales	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_505634_1	402626.Rpic_0311	1.98e-121	353.0	COG0463@1|root,COG0463@2|Bacteria,1QTWH@1224|Proteobacteria,2VKU3@28216|Betaproteobacteria,1K330@119060|Burkholderiaceae	28216|Betaproteobacteria	M	glycosyl transferase family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
k59_930118_1	85643.Tmz1t_2643	1.25e-111	327.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,2KV9V@206389|Rhodocyclales	206389|Rhodocyclales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_635633_1	1120956.JHZK01000042_gene3046	9.3e-69	224.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2015, Alkyl sulfatase and related hydrolases	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_211103_1	436308.Nmar_0193	1.7e-131	387.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_178792_1	1288494.EBAPG3_26810	3.77e-19	80.9	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,373FS@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_81300_1	706587.Desti_2026	3.9e-53	189.0	COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Spermine spermidine synthase	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_374010_1	388739.RSK20926_12759	6.14e-28	110.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2TTMG@28211|Alphaproteobacteria,2P1E2@2433|Roseobacter	28211|Alphaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_374010_2	1380391.JIAS01000013_gene3658	2.55e-42	150.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,2JPJE@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_895943_1	219305.MCAG_01227	8.23e-63	204.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4D9JV@85008|Micromonosporales	201174|Actinobacteria	S	ATPase associated with various cellular activities	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_635637_1	443144.GM21_0513	5.97e-38	139.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_81303_1	335543.Sfum_3370	2.1e-108	324.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria,2MQAM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_146250_1	1485544.JQKP01000012_gene2168	7.02e-64	201.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,44VW2@713636|Nitrosomonadales	28216|Betaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_146250_3	1288494.EBAPG3_29130	1.04e-13	68.9	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,372ZX@32003|Nitrosomonadales	28216|Betaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_274226_1	247490.KSU1_D0037	2.21e-59	195.0	COG3408@1|root,COG3408@2|Bacteria,2J3KJ@203682|Planctomycetes	203682|Planctomycetes	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_100
k59_48095_1	439235.Dalk_2650	5.16e-110	325.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MIG5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_635642_1	335543.Sfum_4058	1.6e-88	274.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria,2MQYA@213462|Syntrophobacterales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_341916_1	1266908.AQPB01000052_gene689	8.51e-54	185.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1WWD0@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_763573_2	62928.azo2017	2.87e-35	132.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,2KUEZ@206389|Rhodocyclales	206389|Rhodocyclales	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_113574_1	383372.Rcas_4328	1.21e-43	157.0	COG0477@1|root,COG2814@2|Bacteria,2G7YK@200795|Chloroflexi,376E9@32061|Chloroflexia	32061|Chloroflexia	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1
k59_701847_1	1232437.KL661988_gene125	5.29e-76	239.0	COG3839@1|root,COG3839@2|Bacteria,1PA89@1224|Proteobacteria,42PEJ@68525|delta/epsilon subdivisions,2WJ1D@28221|Deltaproteobacteria,2MIHS@213118|Desulfobacterales	28221|Deltaproteobacteria	G	ABC transporter	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
k59_113577_1	1499967.BAYZ01000016_gene6532	8.98e-09	60.1	COG1196@1|root,COG1361@1|root,COG5301@1|root,COG5306@1|root,COG1196@2|Bacteria,COG1361@2|Bacteria,COG5301@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	G	cellulose 1,4-beta-cellobiosidase activity	exbB2	-	3.4.14.5,4.2.2.1	ko:K01278,ko:K01727,ko:K03561,ko:K12287,ko:K21449	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02044,ko04090,ko04147	1.A.30.2.1,1.B.40.2	PL8	-	DUF2341,Laminin_G_3,MotA_ExbB
k59_570933_1	911045.PSE_4224	3.38e-51	179.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_505669_2	1163617.SCD_n00559	2.22e-60	194.0	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,2VSI4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
k59_895965_1	1121405.dsmv_2190	2.87e-88	279.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria,2MIMN@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM Peptidoglycan-binding domain 1 protein	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_669044_1	864051.BurJ1DRAFT_0795	3.7e-46	156.0	COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2VQPA@28216|Betaproteobacteria,1KN88@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_341942_1	1232437.KL662000_gene4762	1.05e-42	149.0	COG2204@1|root,COG2204@2|Bacteria,1N2Q1@1224|Proteobacteria,42UAG@68525|delta/epsilon subdivisions,2WQU8@28221|Deltaproteobacteria,2MKH3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_341942_2	247490.KSU1_C1352	5.28e-22	100.0	COG2204@1|root,COG2204@2|Bacteria,2IYIG@203682|Planctomycetes	203682|Planctomycetes	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_734280_1	1357714.A0A067XR41_9CAUD	2.26e-45	167.0	4QF7I@10239|Viruses,4QYCA@35237|dsDNA viruses  no RNA stage,4QT9A@28883|Caudovirales,4QKJH@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_832406_2	335543.Sfum_3164	1.29e-79	247.0	COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,42S1H@68525|delta/epsilon subdivisions,2X5V2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K10003	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	BPD_transp_1
k59_505695_2	1288494.EBAPG3_21420	8.5e-63	196.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,3728J@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_81340_1	228410.NE0386	2.31e-135	399.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2VHCJ@28216|Betaproteobacteria,371N2@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_374063_1	555779.Dthio_PD3802	1.07e-88	296.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_635690_1	1229780.BN381_410025	9.75e-99	310.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria	201174|Actinobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k59_930182_2	443598.AUFA01000043_gene4647	1.47e-33	129.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JTDD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_18835	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_734307_2	1454004.AW11_00696	4.81e-117	338.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,1KPTK@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_734307_3	323848.Nmul_A0792	9.87e-14	69.7	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,372HG@32003|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_374075_1	1454004.AW11_03028	7.12e-33	127.0	COG2220@1|root,COG2220@2|Bacteria,1R5GU@1224|Proteobacteria,2VPH1@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_701899_3	592015.HMPREF1705_02338	2.44e-24	100.0	COG1055@1|root,COG1055@2|Bacteria,3TAK5@508458|Synergistetes	508458|Synergistetes	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_962762_1	497964.CfE428DRAFT_1860	3.76e-58	193.0	COG3464@1|root,COG3464@2|Bacteria,46VFX@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_178867_1	1229909.NSED_00705	5.68e-83	257.0	COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the HMG-CoA reductase family	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
k59_1019636_1	1458275.AZ34_09145	5.49e-15	72.8	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VPNH@28216|Betaproteobacteria,4AJ2D@80864|Comamonadaceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1019636_2	1458275.AZ34_09150	9.43e-58	199.0	COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2VKMT@28216|Betaproteobacteria,4AK08@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_439366_1	1229205.BUPH_03632	5.24e-132	390.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,1K1ET@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_635708_1	639030.JHVA01000001_gene2709	8.67e-34	126.0	28KUD@1|root,2ZAB6@2|Bacteria	2|Bacteria	-	-	yndJ	-	-	-	-	-	-	-	-	-	-	-	YndJ
k59_701910_1	420662.Mpe_A3418	1.68e-94	279.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,1KIUD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_374090_1	1304885.AUEY01000009_gene1933	3.26e-51	177.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,42MQ3@68525|delta/epsilon subdivisions,2WJEE@28221|Deltaproteobacteria,2MHM5@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_178873_1	261292.Nit79A3_1256	1.21e-65	211.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,372D3@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	cbbR	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_178873_2	292415.Tbd_2624	2.36e-189	535.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria	28216|Betaproteobacteria	H	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_643882_1	713586.KB900536_gene2892	6.41e-106	312.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales	135613|Chromatiales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_381898_1	1502851.FG93_03676	3.85e-39	142.0	2BKDV@1|root,32EUJ@2|Bacteria,1N9UU@1224|Proteobacteria,2TSMK@28211|Alphaproteobacteria,3JT65@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_121929_20	1081640.AGFU01000049_gene807	3.01e-22	89.4	2CAY2@1|root,33M0K@2|Bacteria,1NQ04@1224|Proteobacteria,2UJYJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_121929_22	1254432.SCE1572_06075	1.64e-07	57.8	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
k59_121929_24	1192034.CAP_2562	1.18e-57	203.0	COG1061@1|root,COG1061@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2WJWA@28221|Deltaproteobacteria,2Z23A@29|Myxococcales	28221|Deltaproteobacteria	L	PFAM type III restriction protein res subunit	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2,ResIII
k59_121929_28	553217.ENHAE0001_2195	0.000108	48.9	COG1974@1|root,COG1974@2|Bacteria,1RIY3@1224|Proteobacteria,1S2IC@1236|Gammaproteobacteria,3NN9Q@468|Moraxellaceae	1236|Gammaproteobacteria	K	Helix-turn-helix XRE-family like proteins	prpA	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_S24
k59_121929_33	1123227.KB899338_gene1086	3.28e-39	145.0	COG1074@1|root,COG1074@2|Bacteria,1QUUZ@1224|Proteobacteria,2UGBZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PDDEXK-like domain of unknown function (DUF3799)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3799
k59_121929_35	716928.AJQT01000026_gene1836	9.2e-56	192.0	COG0468@1|root,COG0468@2|Bacteria,1PK58@1224|Proteobacteria,2UB77@28211|Alphaproteobacteria,4BIMA@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_24
k59_350198_1	876044.IMCC3088_132	2.61e-23	103.0	2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,1S25X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_742886_1	765912.Thimo_2830	2.62e-136	400.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1WWUB@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_219280_2	720554.Clocl_0324	1.84e-31	117.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WIEP@541000|Ruminococcaceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_938743_1	944564.HMPREF9200_0213	2.04e-08	55.8	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1V3P0@1239|Firmicutes,4H2VG@909932|Negativicutes	909932|Negativicutes	H	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
k59_938743_2	744980.TRICHSKD4_0849	1.98e-29	110.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2U94H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
k59_186731_1	999541.bgla_1g17080	1.61e-68	230.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,1K06F@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_535982_1	93220.LV28_07190	1.53e-71	224.0	COG0559@1|root,COG0559@2|Bacteria,1MYEW@1224|Proteobacteria,2VKZN@28216|Betaproteobacteria,1KGKM@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_350221_1	1000565.METUNv1_01169	2.51e-121	363.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales	206389|Rhodocyclales	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_903821_1	289376.THEYE_A0844	3.29e-45	157.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_611565_1	1454004.AW11_03115	5.3e-74	230.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2VHYY@28216|Betaproteobacteria,1KQV0@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	potI	-	-	ko:K11070,ko:K11074	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	BPD_transp_1
k59_611565_2	1453496.AT03_08025	1.21e-06	49.7	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type spermidine putrescine transport system, permease component I	potH	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K11075	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	iAF1260.b0856,iBWG_1329.BWG_0709,iE2348C_1286.E2348C_0853,iECDH10B_1368.ECDH10B_0926,iECDH1ME8569_1439.ECDH1ME8569_0808,iEcDH1_1363.EcDH1_2786,iJO1366.b0856,iJR904.b0856,iY75_1357.Y75_RS04455	BPD_transp_1
k59_677756_1	1121904.ARBP01000013_gene393	1.3e-37	142.0	COG4784@1|root,COG4784@2|Bacteria,4PM59@976|Bacteroidetes,47MK2@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_411902_1	717785.HYPMC_1888	2.39e-125	372.0	COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,2TT1T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Formylmethanofuran dehydrogenase subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
k59_611572_1	398525.KB900701_gene6702	8.79e-84	269.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_710564_1	1198114.AciX9_1841	3.8e-23	106.0	COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JHXZ@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_447415_1	472759.Nhal_2214	1.11e-64	213.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1WWCY@135613|Chromatiales	135613|Chromatiales	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_219323_1	316067.Geob_0005	8.47e-119	365.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,43T5S@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_315846_1	330214.NIDE0408	4.05e-44	149.0	COG0175@1|root,COG0175@2|Bacteria	2|Bacteria	EH	sulfate reduction	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8,2.7.1.25	ko:K00390,ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R02021,R04928	RC00002,RC00007,RC00078,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_315846_2	44251.PDUR_13435	2.81e-15	79.7	COG0547@1|root,COG0547@2|Bacteria,1V119@1239|Firmicutes,4HF7J@91061|Bacilli,26QNK@186822|Paenibacillaceae	91061|Bacilli	E	Anthranilate phosphoribosyltransferase	-	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_476923_1	1122603.ATVI01000005_gene3042	1.94e-48	165.0	COG0668@1|root,COG0668@2|Bacteria,1N4UN@1224|Proteobacteria,1T9TX@1236|Gammaproteobacteria,1XBUR@135614|Xanthomonadales	135614|Xanthomonadales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_381965_2	330214.NIDE0478	2.47e-84	252.0	COG0588@1|root,COG0588@2|Bacteria,3J118@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_514260_1	1485544.JQKP01000019_gene33	2.32e-73	230.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2VI0Q@28216|Betaproteobacteria,44VFP@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_219333_1	1125863.JAFN01000001_gene885	6.97e-83	259.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM AICARFT IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1023736_1	861299.J421_1876	2.53e-122	367.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_971467_1	946483.Cenrod_0414	2.77e-110	333.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,4AD4V@80864|Comamonadaceae	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3
k59_678684_1	648757.Rvan_1702	1.81e-81	249.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,2TTX1@28211|Alphaproteobacteria,3N6WN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Tellurite resistance protein TerB	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
k59_711468_1	243231.GSU2762	3.47e-74	238.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,42M9Z@68525|delta/epsilon subdivisions,2WIYZ@28221|Deltaproteobacteria,43U0G@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_873099_1	463191.SSEG_01282	1.71e-55	181.0	COG1028@1|root,COG1028@2|Bacteria,2IATI@201174|Actinobacteria	201174|Actinobacteria	IQ	KR domain	-	-	-	ko:K07535	ko00362,ko01120,ko01220,map00362,map01120,map01220	M00540	R05582	RC00154	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
k59_842084_1	1121861.KB899910_gene733	1.64e-06	48.9	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_842084_2	1125973.JNLC01000011_gene602	5.92e-56	190.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_351130_1	228410.NE1482	9.55e-137	395.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,371N5@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_25261_1	679199.HMPREF9332_01034	5.53e-14	76.6	COG4866@1|root,COG4866@2|Bacteria,4NGJE@976|Bacteroidetes,2FNB2@200643|Bacteroidia,1WDUI@1283313|Alloprevotella	976|Bacteroidetes	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	Acetyltransf_9,DUF2156
k59_743894_1	436308.Nmar_0781	2.14e-53	180.0	COG0034@1|root,arCOG00093@2157|Archaea,41S7N@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_220185_1	1500257.JQNM01000014_gene2932	1.6e-200	559.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2TVM0@28211|Alphaproteobacteria,4BARU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	ligJ	-	4.1.1.45,4.2.1.83	ko:K03392,ko:K10220	ko00362,ko00380,ko01100,ko01120,map00362,map00380,map01100,map01120	M00038	R04323,R04478	RC00498,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_453379_1	1163617.SCD_n02637	1.59e-142	416.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_128252_1	330214.NIDE2751	1.97e-55	176.0	COG1259@1|root,COG1259@2|Bacteria,3J0RC@40117|Nitrospirae	40117|Nitrospirae	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
k59_321469_1	278957.ABEA03000022_gene2307	4.24e-47	168.0	COG1052@1|root,COG1052@2|Bacteria,46SAN@74201|Verrucomicrobia,3K77J@414999|Opitutae	414999|Opitutae	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_321470_1	598467.BrE312_0608	2.12e-13	74.7	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RZ7A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_62139_1	991905.SL003B_0207	9.54e-24	99.4	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2U0NP@28211|Alphaproteobacteria,4BS2Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_617719_1	765910.MARPU_07835	6.38e-105	328.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_160822_2	1121033.AUCF01000006_gene4241	1.04e-87	267.0	COG0600@1|root,COG0600@2|Bacteria,1PH8M@1224|Proteobacteria,2V8ZI@28211|Alphaproteobacteria,2JXIM@204441|Rhodospirillales	204441|Rhodospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_387781_2	243233.MCA0647	1.11e-14	75.1	COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,1S588@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_160823_1	330214.NIDE3284	1.08e-48	175.0	COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,3J117@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,PAS_4
k59_716923_2	1054213.HMPREF9946_03374	2.09e-55	178.0	29IJ4@1|root,305GB@2|Bacteria,1N0FK@1224|Proteobacteria,2UDQU@28211|Alphaproteobacteria,2JU5M@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF1579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1579
k59_847639_1	1144342.PMI40_00646	1.9e-31	120.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,472RP@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_847639_2	1161401.ASJA01000021_gene641	3.17e-34	130.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TWH9@28211|Alphaproteobacteria,440V4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k59_225288_2	251229.Chro_2222	1e-39	142.0	COG2062@1|root,COG2062@2|Bacteria,1G76N@1117|Cyanobacteria,3VMHX@52604|Pleurocapsales	1117|Cyanobacteria	T	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_160828_1	1120999.JONM01000002_gene762	1.32e-29	116.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,2KTR6@206351|Neisseriales	206351|Neisseriales	P	Periplasmic binding protein	-	-	-	ko:K02016,ko:K06858	ko02010,map02010	M00240,M00241	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.13,3.A.1.14	-	-	Peripla_BP_2
k59_387787_2	365046.Rta_35120	4.18e-107	339.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4ABU2@80864|Comamonadaceae	28216|Betaproteobacteria	V	Transporter, hydrophobe amphiphile efflux-1 (HAE1) family	bepE	-	-	ko:K18902,ko:K19594	-	M00698,M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.25,2.A.6.2.34	-	-	ACR_tran
k59_62152_1	1000565.METUNv1_03576	4e-23	99.4	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,2VW3K@28216|Betaproteobacteria,2KZ9A@206389|Rhodocyclales	206389|Rhodocyclales	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ACPS
k59_160834_1	1254432.SCE1572_24695	6.77e-23	99.0	COG0500@1|root,COG2226@2|Bacteria,1PVPS@1224|Proteobacteria,43DGN@68525|delta/epsilon subdivisions,2X8NF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_586128_1	1121116.KB894765_gene744	1.88e-07	52.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,4AAWK@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_586128_2	342113.DM82_800	1.83e-75	239.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,1K2CP@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_716939_1	1000565.METUNv1_01394	2.49e-210	604.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,2KV9E@206389|Rhodocyclales	206389|Rhodocyclales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_96327_1	330214.NIDE1515	9.27e-97	295.0	COG0312@1|root,COG0312@2|Bacteria,3J0P7@40117|Nitrospirae	40117|Nitrospirae	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_847660_1	1163617.SCD_n01184	5.8e-105	316.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2VHN9@28216|Betaproteobacteria	28216|Betaproteobacteria	L	AAA ATPase central domain protein	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_776707_1	873448.STRPO_0579	9.24e-08	60.1	COG0451@1|root,COG0451@2|Bacteria,1TS59@1239|Firmicutes,4HC1B@91061|Bacilli	91061|Bacilli	GM	Dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_192975_1	1459636.NTE_02309	2.43e-29	112.0	COG0110@1|root,arCOG01848@2157|Archaea,41SJ0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_30602_1	1492738.FEM21_25670	1.17e-92	280.0	COG0620@1|root,COG0620@2|Bacteria,4PJ3I@976|Bacteroidetes,1IGBI@117743|Flavobacteriia,2NZR0@237|Flavobacterium	976|Bacteroidetes	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_909849_2	76114.ebA1293	1.32e-08	55.1	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,2KUM6@206389|Rhodocyclales	206389|Rhodocyclales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_749500_1	1235835.C814_02366	1.51e-05	51.6	COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,247TW@186801|Clostridia,3WHUC@541000|Ruminococcaceae	186801|Clostridia	K	chromosome partitioning protein K03497	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_776720_1	717785.HYPMC_4181	4.66e-110	325.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria,3N64R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase subunit III	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_30611_1	1038859.AXAU01000002_gene262	0.000499	50.1	COG0737@1|root,COG2374@1|root,COG2931@1|root,COG3204@1|root,COG3391@1|root,COG0737@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3204@2|Bacteria,COG3391@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3JV8J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Big_5,DUF4214,HemolysinCabind,Hint_2
k59_1008575_1	1288494.EBAPG3_4450	2.97e-40	144.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2VKAU@28216|Betaproteobacteria,372AN@32003|Nitrosomonadales	28216|Betaproteobacteria	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like,PBP_like_2
k59_684292_1	706587.Desti_2138	1.63e-59	195.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42RU7@68525|delta/epsilon subdivisions,2WNTU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_945229_1	945713.IALB_1898	2.41e-27	110.0	COG0704@1|root,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_281857_1	977880.RALTA_A2260	1.03e-105	311.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHZW@28216|Betaproteobacteria,1K11F@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_847694_1	765913.ThidrDRAFT_0394	6.1e-16	77.4	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1WXUQ@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
k59_847694_2	1384056.N787_08110	4.25e-42	150.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X55Q@135614|Xanthomonadales	135614|Xanthomonadales	EH	component I	pabB	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_225344_1	1485544.JQKP01000001_gene906	1.26e-81	254.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,44UZZ@713636|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_617779_1	1463825.JNXC01000058_gene1067	7.16e-42	147.0	COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria,4EBK8@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_482292_2	397945.Aave_2660	2.04e-79	242.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,4ACE3@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	tsaC	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_128332_1	439235.Dalk_1872	7.3e-35	139.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2MJNU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
k59_945237_2	1527515.A0A088FB27_9CAUD	2.6e-06	54.7	4QCB0@10239|Viruses,4QPFH@28883|Caudovirales,4QKQY@10699|Siphoviridae	10699|Siphoviridae	S	YqaJ-like viral recombinase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_453458_1	411684.HPDFL43_08399	3.1e-24	95.1	2CEUC@1|root,32S0I@2|Bacteria,1MZ90@1224|Proteobacteria,2UCBC@28211|Alphaproteobacteria,43Q82@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_387847_1	338966.Ppro_1339	1.45e-40	144.0	COG2510@1|root,COG2510@2|Bacteria,1QV9N@1224|Proteobacteria,43BNU@68525|delta/epsilon subdivisions,2X704@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_945241_1	640081.Dsui_2360	2.69e-73	234.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KVE6@206389|Rhodocyclales	206389|Rhodocyclales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Sigma54_activat
k59_356592_1	330214.NIDE2519	2.89e-52	177.0	COG1690@1|root,COG1690@2|Bacteria,3J0X0@40117|Nitrospirae	40117|Nitrospirae	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_453465_1	330214.NIDE1931	3.65e-107	325.0	COG1894@1|root,COG1894@2|Bacteria,3J0WX@40117|Nitrospirae	40117|Nitrospirae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S
k59_716994_1	1120983.KB894572_gene2926	0.000825	41.2	COG2141@1|root,COG2141@2|Bacteria,1PFU1@1224|Proteobacteria,2VA1B@28211|Alphaproteobacteria,1JQ6W@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
k59_716994_2	75379.Tint_0707	2.22e-49	164.0	COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,2VT6G@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_281874_1	999541.bgla_2g18740	2.4e-50	179.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,1K16F@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1027008_1	697282.Mettu_4137	2.44e-75	233.0	COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,1RNTH@1236|Gammaproteobacteria,1XF3M@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Nickel-dependent hydrogenase b-type cytochrome subunit	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_776764_1	748280.NH8B_2972	2.13e-85	265.0	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,2VM0X@28216|Betaproteobacteria,2KSQI@206351|Neisseriales	206351|Neisseriales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_945265_1	1452536.JARE01000004_gene686	6.78e-41	136.0	COG0186@1|root,COG0186@2|Bacteria,2IQ68@201174|Actinobacteria,4FP9J@85023|Microbacteriaceae	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_945265_2	981369.JQMJ01000004_gene3177	3.47e-13	64.7	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,2NIPU@228398|Streptacidiphilus	201174|Actinobacteria	J	Ribosomal protein L14p/L23e	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_128366_1	935565.JAEM01000002_gene3704	7.02e-99	302.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,2PUPR@265|Paracoccus	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_617815_1	1249480.B649_05630	8.73e-67	217.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2YME5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_521752_1	670292.JH26_03345	1.19e-33	129.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,1JTRM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	TIGRFAM TRAP transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_685211_2	1123261.AXDW01000003_gene1982	4.66e-106	322.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,1RMY2@1236|Gammaproteobacteria,1XDBK@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_483064_1	640081.Dsui_1101	1.3e-76	247.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,2KVCK@206389|Rhodocyclales	206389|Rhodocyclales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_946137_1	153948.NAL212_0605	5.78e-56	198.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,372K8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_129254_1	857087.Metme_4144	1.28e-27	115.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1XDR6@135618|Methylococcales	135618|Methylococcales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_848616_1	671143.DAMO_1115	7.5e-25	105.0	COG0745@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2NQ9F@2323|unclassified Bacteria	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_322368_1	1122239.AULS01000003_gene2664	7.65e-37	142.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria,4FMRS@85023|Microbacteriaceae	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_193887_1	754027.HMPREF9554_01924	7.31e-17	81.6	COG1281@1|root,COG1281@2|Bacteria,2J58S@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG1281 Disulfide bond chaperones of the HSP33 family	-	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_193887_2	690850.Desaf_3080	1.48e-33	126.0	COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,42MJX@68525|delta/epsilon subdivisions,2WJDM@28221|Deltaproteobacteria,2M8QZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM tRNA synthetase class II (D K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_129257_1	583355.Caka_1160	3.71e-06	50.4	COG0438@1|root,COG0438@2|Bacteria,46TNP@74201|Verrucomicrobia	74201|Verrucomicrobia	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_129257_2	665571.STHERM_c02540	1.1e-20	91.3	COG1215@1|root,COG1215@2|Bacteria,2J64X@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase family 2	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2
k59_685225_1	1286631.X805_00270	6.52e-111	353.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,1KJC4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
k59_388806_1	1267005.KB911265_gene3600	4.33e-52	185.0	COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria,3N6K0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	divL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,PAS_8
k59_418292_1	477184.KYC_08800	4.07e-81	251.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2VM2C@28216|Betaproteobacteria,3T6AI@506|Alcaligenaceae	28216|Betaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_63052_1	556268.OFAG_00266	4.61e-12	66.6	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2VR65@28216|Betaproteobacteria,4740H@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_226204_1	1301098.PKB_2133	2.28e-23	99.8	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RPJY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	flavoprotein involved in K transport	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_3
k59_427759_1	1121918.ARWE01000001_gene2375	1.7e-69	231.0	COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,1MXNJ@1224|Proteobacteria,43A4W@68525|delta/epsilon subdivisions,2X2I0@28221|Deltaproteobacteria,43VI8@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_884607_1	977880.RALTA_A1772	1.53e-33	126.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VKFT@28216|Betaproteobacteria,1K0JH@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	lytT	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
k59_3499_1	1530186.JQEY01000005_gene3527	7.43e-21	92.8	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TQXH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Multi-copper	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_362436_1	1380355.JNIJ01000038_gene4916	6.55e-76	234.0	COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,2U66N@28211|Alphaproteobacteria,3JYD3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
k59_656657_2	1121405.dsmv_1664	2.74e-31	115.0	COG2010@1|root,COG2010@2|Bacteria,1RDVX@1224|Proteobacteria,42WYA@68525|delta/epsilon subdivisions,2WT1Y@28221|Deltaproteobacteria,2MNSF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
k59_689321_1	760117.JN27_17055	1.47e-52	177.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,4730U@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	intramolecular transferase activity, transferring amino groups	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_689321_2	1502850.FG91_00261	7.72e-09	58.5	COG0352@1|root,COG0352@2|Bacteria,1MV42@1224|Proteobacteria,2TSSA@28211|Alphaproteobacteria,2K16H@204457|Sphingomonadales	204457|Sphingomonadales	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
k59_852155_1	426114.THI_0065	1.78e-16	84.3	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VK6J@28216|Betaproteobacteria	28216|Betaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_297122_1	1124780.ANNU01000008_gene2767	5.87e-29	119.0	COG0642@1|root,COG3829@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,4NDXU@976|Bacteroidetes,47JK3@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_36212_1	247633.GP2143_01280	5.95e-53	183.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1J57H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG2148 Sugar transferases involved in lipopolysaccharide synthesis	lthA	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
k59_264778_1	945713.IALB_1578	8.71e-65	222.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	bprV	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_S8
k59_950266_1	1123392.AQWL01000002_gene1876	1.84e-07	50.4	2AG05@1|root,31646@2|Bacteria,1PWTJ@1224|Proteobacteria,2WCCA@28216|Betaproteobacteria,1KTET@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_950266_3	1123392.AQWL01000006_gene707	5.68e-83	258.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,2VZZT@28216|Betaproteobacteria,1KSKS@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_460149_1	278957.ABEA03000203_gene2703	4.47e-17	77.8	COG4747@1|root,COG4747@2|Bacteria,46SXP@74201|Verrucomicrobia,3K816@414999|Opitutae	414999|Opitutae	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_591213_1	572547.Amico_0208	2.07e-125	370.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
k59_297129_2	1192034.CAP_2430	1.75e-31	120.0	COG0746@1|root,COG0746@2|Bacteria,1RKCH@1224|Proteobacteria,42T8X@68525|delta/epsilon subdivisions,2X9X1@28221|Deltaproteobacteria,2YW7C@29|Myxococcales	28221|Deltaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_394895_1	748280.NH8B_1812	2.58e-32	120.0	2A8Q5@1|root,30XSS@2|Bacteria,1RGZW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_394895_2	1266925.JHVX01000002_gene1009	9.57e-76	234.0	COG2345@1|root,COG2345@2|Bacteria,1PW50@1224|Proteobacteria,2VVBN@28216|Betaproteobacteria,37323@32003|Nitrosomonadales	28216|Betaproteobacteria	K	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_5
k59_394895_3	1123487.KB892840_gene76	2.93e-92	274.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,2VQ8C@28216|Betaproteobacteria,2KVM0@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	padE	-	1.2.1.58	ko:K18357	ko00360,map00360	-	R02450	RC00004,RC02860	br01601,ko00000,ko00001,ko01000	-	-	-	POR
k59_753856_1	264198.Reut_B5589	1.12e-27	111.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_753856_2	1157708.KB907456_gene2461	1.44e-28	109.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2VQ5D@28216|Betaproteobacteria,4ADG2@80864|Comamonadaceae	28216|Betaproteobacteria	J	endoribonuclease L-PSP	tdcF2	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
k59_656675_1	153948.NAL212_3050	7.63e-22	90.5	COG2963@1|root,COG3436@1|root,COG2963@2|Bacteria,COG3436@2|Bacteria,1N0VT@1224|Proteobacteria,2VU2C@28216|Betaproteobacteria,373R9@32003|Nitrosomonadales	28216|Betaproteobacteria	L	IS66 Orf2-like	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_656675_2	1123228.AUIH01000144_gene3022	6.62e-11	65.9	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,1SE0M@1236|Gammaproteobacteria,1XRZD@135619|Oceanospirillales	135619|Oceanospirillales	S	IS66 C-terminal element	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C
k59_884630_1	265072.Mfla_0078	1.1e-177	510.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KKZR@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	General secretory system II protein E domain protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_264790_1	330214.NIDE0342	1.41e-72	242.0	COG1305@1|root,COG1305@2|Bacteria,3J150@40117|Nitrospirae	40117|Nitrospirae	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,Transglut_core
k59_721850_1	595460.RRSWK_05503	3.85e-24	107.0	COG1572@1|root,COG2931@1|root,COG3291@1|root,COG3386@1|root,COG3420@1|root,COG4257@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG3420@2|Bacteria,COG4257@2|Bacteria,2J2YS@203682|Planctomycetes	203682|Planctomycetes	P	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_68989_1	1049564.TevJSym_ac01400	1.07e-42	164.0	28N8G@1|root,2ZBCV@2|Bacteria,1NMB1@1224|Proteobacteria,1SMP0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_362468_1	224911.27356077	6.61e-67	208.0	28N0F@1|root,2ZB6V@2|Bacteria,1R4J3@1224|Proteobacteria,2TYJU@28211|Alphaproteobacteria,3JTQM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	MA20_06690	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
k59_134240_1	349124.Hhal_0946	9.64e-21	89.7	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1WWVS@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_134240_2	247634.GPB2148_734	6.58e-21	89.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1J6HX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	integral membrane protein	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_689348_1	436308.Nmar_1714	5.95e-63	203.0	COG4591@1|root,arCOG02313@2157|Archaea,41TBB@651137|Thaumarchaeota	651137|Thaumarchaeota	M	FtsX-like permease family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_69001_1	1265505.ATUG01000001_gene3897	8.13e-96	305.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42YJQ@68525|delta/epsilon subdivisions,2WTJP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_558739_1	1147140.H6WRT2_9CAUD	1.03e-35	145.0	4QBXF@10239|Viruses,4QWG4@35237|dsDNA viruses  no RNA stage,4QRDH@28883|Caudovirales,4QMR4@10699|Siphoviridae	10699|Siphoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_721872_1	502025.Hoch_2529	1.17e-36	144.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2YXGU@29|Myxococcales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_493504_1	987059.RBXJA2T_18989	2.78e-24	101.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,1KITK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_493504_2	870187.Thini_3583	2.44e-12	66.2	2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,1S4JB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2889)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2889
k59_753883_1	269796.Rru_A3160	6.84e-69	219.0	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2TTBR@28211|Alphaproteobacteria,2JS5P@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_852201_1	330214.NIDE0836	3.22e-94	296.0	COG1048@1|root,COG1048@2|Bacteria,3J0E6@40117|Nitrospirae	40117|Nitrospirae	C	Aconitase C-terminal domain	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_852201_2	330214.NIDE0837	1.98e-41	150.0	COG2838@1|root,COG2838@2|Bacteria	2|Bacteria	C	Isocitrate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
k59_917900_1	3218.PP1S133_69V6.1	4.63e-84	265.0	COG1052@1|root,KOG0069@2759|Eukaryota,37IZW@33090|Viridiplantae,3G9SJ@35493|Streptophyta	35493|Streptophyta	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009853,GO:0009854,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0043094,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.237	ko:K15919,ko:K18606	ko00130,ko00260,ko00350,ko00360,ko00630,ko00960,ko01100,ko01110,ko01130,ko01200,map00130,map00260,map00350,map00360,map00630,map00960,map01100,map01110,map01130,map01200	M00532	R01370,R01388,R03336,R03373	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C,NAD_binding_2
k59_917900_2	1205680.CAKO01000010_gene4021	4.62e-05	45.8	COG0477@1|root,COG2814@2|Bacteria,1QUY6@1224|Proteobacteria,2TWZ0@28211|Alphaproteobacteria,2JR9Y@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_950313_1	1123368.AUIS01000004_gene125	3.38e-64	210.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,2NCIC@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_558750_1	1510531.JQJJ01000002_gene4999	2.38e-80	245.0	COG0684@1|root,COG0684@2|Bacteria,1QSHP@1224|Proteobacteria,2U948@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
k59_689377_1	1125863.JAFN01000001_gene1482	1.59e-119	356.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
k59_231723_2	926551.KB900709_gene1123	3.1e-32	123.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,1HZK0@117743|Flavobacteriia,1EQBM@1016|Capnocytophaga	976|Bacteroidetes	K	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
k59_950324_1	1217718.ALOU01000083_gene2978	2.65e-80	263.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1K5NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1013951_1	296591.Bpro_2797	2.84e-148	431.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4AAW5@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_167774_1	1122919.KB905592_gene4179	8.9e-31	119.0	COG3267@1|root,COG3267@2|Bacteria,1TRGM@1239|Firmicutes,4HFK7@91061|Bacilli,26WEG@186822|Paenibacillaceae	91061|Bacilli	U	Type II secretory pathway, component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_428659_1	977880.RALTA_A2961	2.14e-31	115.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2VQ7A@28216|Betaproteobacteria,1K2TS@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_690286_1	330214.NIDE0166	6.5e-119	349.0	COG1063@1|root,COG4585@1|root,COG1063@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	1.1.1.103,2.7.13.3	ko:K00060,ko:K07777	ko00260,ko02020,map00260,map02020	M00478	R01465	RC00525	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA_3,NAS
k59_167775_1	483219.LILAB_01375	3.13e-64	218.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2WIM4@28221|Deltaproteobacteria,2YUC0@29|Myxococcales	28221|Deltaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_722799_1	1121405.dsmv_2974	9.15e-122	377.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2X5GV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_102477_1	1246995.AFR_22465	1.23e-37	135.0	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria,4D8MM@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_102477_2	1187851.A33M_2481	2.63e-07	51.2	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,3FCW3@34008|Rhodovulum	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_01305	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_983574_2	1267005.KB911256_gene1769	8.01e-21	91.3	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2TRZ5@28211|Alphaproteobacteria,3N6SW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_918829_1	1276920.ADIAG_00264	2.34e-16	83.6	COG1262@1|root,COG1262@2|Bacteria,2GN0F@201174|Actinobacteria,1WB41@1268|Micrococcaceae	201174|Actinobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
k59_4494_1	1158294.JOMI01000004_gene3528	1.05e-99	302.0	COG0499@1|root,COG0499@2|Bacteria,4NEKE@976|Bacteroidetes,2FPWZ@200643|Bacteroidia	976|Bacteroidetes	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_784973_2	82654.Pse7367_3563	9.3e-39	138.0	COG0194@1|root,COG0194@2|Bacteria,1G515@1117|Cyanobacteria,1HAKW@1150|Oscillatoriales	1117|Cyanobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_428682_2	305700.B447_13784	2.86e-42	149.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,2KV3P@206389|Rhodocyclales	206389|Rhodocyclales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_754580_1	640081.Dsui_3510	3.74e-140	414.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,2KUSZ@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_657681_1	398767.Glov_1689	1.94e-38	138.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	Nitro_FeMo-Co,ParA
k59_330912_1	1123377.AUIV01000007_gene1302	5.05e-86	267.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1X3PC@135614|Xanthomonadales	135614|Xanthomonadales	C	acetyltransferase component of pyruvate dehydrogenase complex	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_951244_1	397288.C806_03742	7.71e-55	182.0	COG1028@1|root,COG1028@2|Bacteria,1TRYD@1239|Firmicutes,248RG@186801|Clostridia,27KIC@186928|unclassified Lachnospiraceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_298037_1	359.CN09_12330	5.97e-143	412.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,4B8H0@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	dehydrogenase	ivd	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_37211_1	1403819.BATR01000005_gene162	7.01e-75	236.0	COG0451@1|root,COG0451@2|Bacteria,46TXA@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Male sterility protein	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_559705_1	1123366.TH3_15314	7.92e-09	58.5	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,2JQ9I@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0656 Aldo keto reductases, related to diketogulonate reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_559705_2	1205680.CAKO01000035_gene262	6.78e-34	129.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_428709_1	1265502.KB905931_gene1612	4.67e-58	195.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,4AAV7@80864|Comamonadaceae	28216|Betaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360	5.4.4.3,6.3.1.2	ko:K01915,ko:K20712	ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253,R06988,R09284	RC00010,RC01754,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_69987_1	765910.MARPU_15895	2.54e-23	99.4	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales	135613|Chromatiales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_69987_2	519989.ECTPHS_03919	1.1e-120	353.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1WWU0@135613|Chromatiales	135613|Chromatiales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_102518_1	945713.IALB_0217	1.8e-108	341.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_885556_2	765911.Thivi_3041	2.99e-74	229.0	COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,1S0J9@1236|Gammaproteobacteria,1WX5M@135613|Chromatiales	135613|Chromatiales	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
k59_173579_1	1041142.ATTP01000019_gene5198	3.39e-78	243.0	COG3718@1|root,COG3718@2|Bacteria,1MWGD@1224|Proteobacteria,2TUJZ@28211|Alphaproteobacteria,4BBVH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	KduI/IolB family	iolB2	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
k59_173579_2	93220.LV28_08060	6.63e-22	93.6	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VMJ5@28216|Betaproteobacteria,1K4W6@119060|Burkholderiaceae	28216|Betaproteobacteria	P	abc transporter, permease	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_989179_1	1454004.AW11_00944	7.67e-18	84.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,1KQ63@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	acsA_2	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C,PP-binding,Thioesterase
k59_989179_2	1298867.AUES01000067_gene5125	2.29e-07	56.2	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_271409_1	1123269.NX02_17045	2.7e-32	126.0	COG1960@1|root,COG1960@2|Bacteria,1PRJJ@1224|Proteobacteria,2UQWF@28211|Alphaproteobacteria,2K1XZ@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
k59_597983_2	1298867.AUES01000008_gene5160	5.73e-80	246.0	COG0179@1|root,COG0179@2|Bacteria,1R7SI@1224|Proteobacteria,2VFC0@28211|Alphaproteobacteria,3K3FV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_957252_1	1203554.HMPREF1476_01834	2.01e-136	392.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,4PQCI@995019|Sutterellaceae	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
k59_565579_1	1121413.JMKT01000009_gene2187	2.06e-36	144.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2M8F9@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Signal transducing histidine kinase homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_369038_1	671143.DAMO_0537	1.58e-95	290.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_434247_1	1218084.BBJK01000007_gene1059	7.77e-71	234.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,2WHH3@28216|Betaproteobacteria,1KIP3@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
k59_728795_1	981384.AEYW01000007_gene1156	1.9e-48	171.0	COG2114@1|root,COG2343@1|root,COG2114@2|Bacteria,COG2343@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria,4NAW3@97050|Ruegeria	28211|Alphaproteobacteria	T	Adenylate guanylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,NTP_transf_9
k59_663589_1	1121439.dsat_1636	1.97e-47	164.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2WJX5@28221|Deltaproteobacteria,2MA0E@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_400330_1	1265313.HRUBRA_01225	2.04e-68	215.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_400330_2	713586.KB900536_gene1456	3.3e-09	57.4	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,1WZFI@135613|Chromatiales	135613|Chromatiales	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_890966_2	163908.KB235896_gene4823	7.4e-05	43.9	COG1335@1|root,COG1335@2|Bacteria,1G3QK@1117|Cyanobacteria	1117|Cyanobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_303424_1	398525.KB900701_gene6702	2.18e-159	469.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_500408_1	349521.HCH_05407	2.75e-25	107.0	COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,1RMJH@1236|Gammaproteobacteria,1XHTX@135619|Oceanospirillales	135619|Oceanospirillales	M	Phospholipase	pldA	-	3.1.1.32,3.1.1.4	ko:K01058	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110	-	R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000	-	-	-	PLA1
k59_630494_1	795666.MW7_1347	1.18e-56	192.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VNEF@28216|Betaproteobacteria,1K4AV@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_565603_1	1265313.HRUBRA_00929	2.47e-75	241.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_303430_1	153948.NAL212_2991	1.88e-55	189.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,3722Y@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_369067_1	1380394.JADL01000004_gene5935	5e-92	283.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,2JR5U@204441|Rhodospirillales	204441|Rhodospirillales	E	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_173631_1	864702.OsccyDRAFT_3160	7.79e-32	128.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HABM@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
k59_336726_2	266264.Rmet_1388	4.24e-38	141.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VJ8W@28216|Betaproteobacteria,1K21Y@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	dmlR2	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1016893_1	1081640.AGFU01000048_gene638	4.45e-19	85.9	COG2801@1|root,COG2801@2|Bacteria,1MY62@1224|Proteobacteria,2U0GY@28211|Alphaproteobacteria,2K26U@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_1016893_2	748658.KB907316_gene620	8.89e-69	218.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,1RQHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,LZ_Tnp_IS481,rve
k59_205994_1	330214.NIDE0562	2.18e-109	334.0	COG0589@1|root,COG1592@1|root,COG0589@2|Bacteria,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	usp1	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	DinB_2,Rubrerythrin,Usp
k59_10611_1	265072.Mfla_0697	5.02e-32	119.0	COG3165@1|root,COG3165@2|Bacteria,1N314@1224|Proteobacteria,2VU2B@28216|Betaproteobacteria,2KMY8@206350|Nitrosomonadales	206350|Nitrosomonadales	S	SCP-2 sterol transfer family	-	-	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
k59_10611_2	667632.KB890217_gene4825	4.1e-13	68.9	COG4395@1|root,COG4395@2|Bacteria,1RAHC@1224|Proteobacteria,2WFJA@28216|Betaproteobacteria,1KI2S@119060|Burkholderiaceae	28216|Betaproteobacteria	S	import inner membrane translocase, subunit Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
k59_303443_1	1121106.JQKB01000002_gene3483	2.31e-49	177.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VF7J@28211|Alphaproteobacteria,2JRGK@204441|Rhodospirillales	204441|Rhodospirillales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4384,Pkinase
k59_565621_1	395495.Lcho_4204	2.62e-66	218.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,1KJHG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_565621_2	864051.BurJ1DRAFT_0511	2e-49	167.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1KJCD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_465501_1	1205680.CAKO01000042_gene5417	3.35e-65	211.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_759849_1	290400.Jann_1453	1.99e-25	107.0	COG0329@1|root,COG0329@2|Bacteria,1R73B@1224|Proteobacteria,2U0S8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_759849_2	1122599.AUGR01000010_gene1004	8.19e-52	175.0	COG3821@1|root,COG3821@2|Bacteria,1RDXR@1224|Proteobacteria,1S43M@1236|Gammaproteobacteria,1XJVM@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF599
k59_827624_1	1446473.JHWH01000001_gene1328	1.25e-11	73.6	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2PUUF@265|Paracoccus	28211|Alphaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_271890_1	1071679.BG57_28730	1.62e-85	261.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,1K04E@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_925490_1	32042.PstZobell_04626	2.58e-12	69.7	COG2854@1|root,COG2854@2|Bacteria,1QDYR@1224|Proteobacteria,1TA6W@1236|Gammaproteobacteria,1Z1FT@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents, auxiliary component	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_989950_1	883109.HMPREF0380_00993	2.11e-06	50.4	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,3WCN0@538999|Clostridiales incertae sedis	186801|Clostridia	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_989950_2	205918.Psyr_1478	1.65e-09	60.8	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1Z6ED@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	K	Transcriptional regulator	yeiE	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_566315_1	497321.C664_06623	5.8e-93	284.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,2KV2B@206389|Rhodocyclales	206389|Rhodocyclales	E	homoserine dehydrogenase	thrA	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_501128_1	873449.STRCR_1074	5.98e-13	75.1	COG5433@1|root,COG5433@2|Bacteria,1UZWV@1239|Firmicutes	1239|Firmicutes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_664350_1	876269.ARWA01000001_gene2004	1.95e-37	142.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3NCSI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	MA20_01895	-	1.3.99.27	ko:K09845	ko00906,ko01100,map00906,map01100	-	R07517,R07520,R07523,R07534	RC02080	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
k59_598777_1	945713.IALB_1711	5.87e-136	398.0	COG1239@1|root,COG1239@2|Bacteria	2|Bacteria	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0958	Mg_chelatase,Sigma54_activat
k59_304090_1	56780.SYN_02657	3.43e-60	196.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,42TG6@68525|delta/epsilon subdivisions,2WQ8T@28221|Deltaproteobacteria,2MRYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_925513_1	1237500.ANBA01000028_gene4900	6.76e-54	179.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4EIFM@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
k59_697122_1	580332.Slit_0168	5.91e-103	305.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,44VK9@713636|Nitrosomonadales	28216|Betaproteobacteria	IQ	KR domain	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.100,1.5.1.33	ko:K00059,ko:K03793	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_466061_1	479436.Vpar_0709	2.7e-89	287.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4H24Z@909932|Negativicutes	909932|Negativicutes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_76726_1	1000565.METUNv1_02752	6.78e-11	66.2	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,2KU7R@206389|Rhodocyclales	206389|Rhodocyclales	DM	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
k59_729561_1	667632.KB890219_gene647	1.48e-81	258.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,1K4T4@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the malate synthase family	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_529673_1	1521187.JPIM01000021_gene146	2.91e-69	216.0	COG2197@1|root,COG2197@2|Bacteria,2G6T1@200795|Chloroflexi,376HK@32061|Chloroflexia	32061|Chloroflexia	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_729563_1	1276756.AUEX01000001_gene1063	2.44e-96	306.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,4ACV8@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_598790_1	765911.Thivi_3470	3.26e-100	303.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales	135613|Chromatiales	U	Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_206720_1	1000565.METUNv1_03478	6.88e-136	392.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,2KUZ9@206389|Rhodocyclales	206389|Rhodocyclales	E	5,10-methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_206720_2	398527.Bphyt_3758	7.27e-78	245.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,1K11D@119060|Burkholderiaceae	28216|Betaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_925525_1	522306.CAP2UW1_2826	7.71e-68	224.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KQAC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	SNARE associated Golgi protein	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_925525_2	522306.CAP2UW1_2827	3.36e-90	273.0	COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,2VP38@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
k59_664386_1	1048834.TC41_1197	2.65e-41	152.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,4H9T1@91061|Bacilli,2782R@186823|Alicyclobacillaceae	91061|Bacilli	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_174392_1	1485544.JQKP01000011_gene742	1.41e-98	300.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKJI@28216|Betaproteobacteria,44VNF@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_566355_1	398767.Glov_1837	2.25e-13	71.2	COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,43C51@68525|delta/epsilon subdivisions,2X7FD@28221|Deltaproteobacteria,43UVX@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_566355_2	639030.JHVA01000001_gene2045	3.59e-06	51.6	COG1960@1|root,COG1960@2|Bacteria,3Y32R@57723|Acidobacteria,2JIRM@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.99.12	ko:K00248,ko:K09478	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_664387_1	555779.Dthio_PD0327	1.15e-18	82.4	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2M9CC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_664387_2	1121405.dsmv_3590	3.26e-62	191.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria,2MK4M@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_729580_1	1038866.KB902791_gene3232	2.39e-59	192.0	COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,1QWKB@1224|Proteobacteria,2TX0H@28211|Alphaproteobacteria,3K6RB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE,Guanylate_cyc,Hydrolase_4
k59_891730_1	1095769.CAHF01000007_gene1683	1.26e-98	293.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2VHU8@28216|Betaproteobacteria,47273@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	fabG3	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_891730_2	1244869.H261_02306	2.46e-34	134.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1Q44M@1224|Proteobacteria,2V6EC@28211|Alphaproteobacteria,2JQ16@204441|Rhodospirillales	204441|Rhodospirillales	CEH	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_1017361_1	1121406.JAEX01000007_gene2381	6.45e-93	286.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,42NHS@68525|delta/epsilon subdivisions,2WJHI@28221|Deltaproteobacteria,2MAE5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NAD(P) transhydrogenase beta subunit	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_174400_1	1408473.JHXO01000001_gene1993	1.44e-18	82.8	COG1006@1|root,COG1006@2|Bacteria,4NQ8N@976|Bacteroidetes,2FYR7@200643|Bacteroidia	976|Bacteroidetes	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	mrpC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_174400_2	1245471.PCA10_16040	1.13e-23	103.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1YFJI@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	CP	Domain related to MnhB subunit of Na+/H+ antiporter	phaA	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_501181_1	573370.DMR_43530	2.86e-68	218.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,42RYH@68525|delta/epsilon subdivisions,2WNT0@28221|Deltaproteobacteria,2MBQC@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_631192_1	1408473.JHXO01000005_gene1599	1.8e-16	84.0	COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,2FPPN@200643|Bacteroidia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_76753_1	358220.C380_10860	4.67e-17	79.7	COG1670@1|root,COG1670@2|Bacteria,1ND46@1224|Proteobacteria,2W4JU@28216|Betaproteobacteria	28216|Betaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_664399_1	748247.AZKH_4212	7.95e-64	209.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,2KUS9@206389|Rhodocyclales	206389|Rhodocyclales	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_501193_1	945713.IALB_2676	1.3e-75	231.0	COG4947@1|root,COG4947@2|Bacteria	2|Bacteria	P	esterase	XK27_05675	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_174411_1	330214.NIDE0866	4.93e-74	228.0	COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae	40117|Nitrospirae	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_43733_1	1437824.BN940_00826	0.000592	42.7	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,3T2AE@506|Alcaligenaceae	28216|Betaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_43733_2	1266925.JHVX01000008_gene372	1.87e-127	369.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,371Z8@32003|Nitrosomonadales	28216|Betaproteobacteria	D	PFAM Cobyrinic acid a,c-diamide synthase	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_309997_2	388399.SSE37_09123	1.46e-13	72.8	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_471412_1	1384056.N787_10330	1.37e-34	132.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,1X47N@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Major facilitator superfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_572902_1	338966.Ppro_1841	3.99e-91	277.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
k59_637523_1	742823.HMPREF9465_00300	2.04e-113	344.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,4PQQW@995019|Sutterellaceae	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	frdA	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_275148_1	330214.NIDE4115	5.98e-111	328.0	COG0436@1|root,COG0436@2|Bacteria,3J0ED@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_572909_1	177437.HRM2_08570	1.14e-83	256.0	COG0667@1|root,COG0667@2|Bacteria,1QJYC@1224|Proteobacteria,42QD6@68525|delta/epsilon subdivisions,2WJ6W@28221|Deltaproteobacteria,2MIY6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_996302_1	1122603.ATVI01000008_gene2344	8.13e-13	72.0	COG5526@1|root,COG5526@2|Bacteria,1RA0A@1224|Proteobacteria,1S4KY@1236|Gammaproteobacteria,1X9U5@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_897688_1	1173022.Cri9333_4694	2.24e-143	425.0	COG3039@1|root,COG3039@2|Bacteria,1G3YX@1117|Cyanobacteria,1H8DI@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF772
k59_17873_1	1205680.CAKO01000010_gene3933	7.09e-39	137.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria,2JU7K@204441|Rhodospirillales	204441|Rhodospirillales	C	Prokaryotic cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_115556_2	945713.IALB_0930	1.16e-25	95.9	COG1841@1|root,COG1841@2|Bacteria	2|Bacteria	J	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_115556_3	945713.IALB_0931	3.43e-60	189.0	COG0200@1|root,COG0200@2|Bacteria	2|Bacteria	J	rRNA binding	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_83265_2	945713.IALB_1502	1.85e-85	260.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	korB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_376469_1	395019.Bmul_5725	1.96e-82	251.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,1K13F@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_898228_1	1131553.JIBI01000019_gene490	9.2e-31	117.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,3725K@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_898228_2	582744.Msip34_0463	7.24e-23	95.9	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,2KKG2@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_441741_1	1217718.ALOU01000026_gene3554	3.39e-69	213.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,1JZYT@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
k59_573491_1	1517416.IDAT_11085	1.37e-58	190.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,2QFJ3@267893|Idiomarinaceae	1236|Gammaproteobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_533071_1	646529.Desaci_1066	2.21e-77	245.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,24AES@186801|Clostridia,260Y9@186807|Peptococcaceae	186801|Clostridia	Q	Aromatic ring hydroxylase	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
k59_834969_1	945713.IALB_0147	1.71e-55	194.0	COG2234@1|root,COG4412@1|root,COG2234@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.4.11.10,3.4.21.50	ko:K01337,ko:K05994,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF4968,DUF5110,F5_F8_type_C,Glyco_hydro_31,PA,Peptidase_M28,Peptidase_M6,Peptidase_S8,W_rich_C
k59_181305_1	1266925.JHVX01000007_gene2376	7.18e-182	525.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,372MQ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_573493_1	670307.HYPDE_23693	9.64e-63	204.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
k59_765791_2	395495.Lcho_4136	6.25e-10	60.8	COG2010@1|root,COG2010@2|Bacteria,1R6Z0@1224|Proteobacteria,2VRTH@28216|Betaproteobacteria,1KNJH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,DUF302
k59_965353_1	269799.Gmet_2197	7.56e-16	75.9	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42M0D@68525|delta/epsilon subdivisions,2WK8T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_965353_2	614083.AWQR01000011_gene2383	1.59e-52	185.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,4AAB0@80864|Comamonadaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB2	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_508229_1	1142394.PSMK_28660	7.02e-32	125.0	COG0836@1|root,COG0836@2|Bacteria,2IXAR@203682|Planctomycetes	203682|Planctomycetes	M	Mannose-1-phosphate guanylyltransferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_638080_1	1411123.JQNH01000001_gene2713	1.5e-105	324.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_736880_1	257313.BP2307	4.44e-59	197.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,3T257@506|Alcaligenaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_471907_2	272560.BPSS1159	1.2e-74	248.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,1K2CI@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_965355_1	595537.Varpa_0809	1.25e-105	316.0	COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria,2VME7@28216|Betaproteobacteria,4AASE@80864|Comamonadaceae	28216|Betaproteobacteria	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_83891_1	330214.NIDE0422	1.27e-84	258.0	COG0287@1|root,COG0287@2|Bacteria,3J0SQ@40117|Nitrospirae	40117|Nitrospirae	C	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_441774_1	381666.H16_A1819	8.73e-26	104.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,2VHKW@28216|Betaproteobacteria,1JZRD@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_441774_2	381666.H16_A1818	1.28e-117	342.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2VJTG@28216|Betaproteobacteria,1K25X@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_835010_1	887898.HMPREF0551_1003	1.2e-25	102.0	COG0664@1|root,COG0664@2|Bacteria,1RE4X@1224|Proteobacteria,2VRYB@28216|Betaproteobacteria,1K34H@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_835010_2	1123354.AUDR01000018_gene1197	1.36e-05	45.8	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,1KRGV@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_965367_1	1123392.AQWL01000006_gene702	7.4e-06	46.2	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,1KS73@119069|Hydrogenophilales	119069|Hydrogenophilales	T	cheY-homologous receiver domain	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_965367_2	1121004.ATVC01000091_gene645	1.31e-18	86.7	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VKMW@28216|Betaproteobacteria,2KQU1@206351|Neisseriales	206351|Neisseriales	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PhaC_N
k59_508247_1	7955.ENSDARP00000097435	0.000644	41.6	COG0346@1|root,2S0RY@2759|Eukaryota,3A1QJ@33154|Opisthokonta,3CPC2@33208|Metazoa,3E5GR@33213|Bilateria,48RQV@7711|Chordata,49NDA@7742|Vertebrata,4A3TY@7898|Actinopterygii	33208|Metazoa	E	Glyoxalase domain containing 5	GLOD5	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_508247_2	420662.Mpe_A2722	1.52e-64	210.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,1KK8Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_344450_1	1111728.ATYS01000028_gene2659	2.21e-07	53.1	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,1RQ5K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC transporter substrate-binding protein	-	-	5.3.3.7	ko:K02020,ko:K22003	ko00660,ko02010,map00660,map02010	M00189	R02244	RC00668	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_344450_2	3988.XP_002537545.1	1.08e-58	194.0	COG4948@1|root,2QRKX@2759|Eukaryota	2759|Eukaryota	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.90	ko:K12661	ko00051,ko01120,map00051,map01120	-	R03774	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_765824_1	272559.BF9343_2339	4.45e-05	49.7	2ARB9@1|root,31GMA@2|Bacteria,4NRRD@976|Bacteroidetes,2FVP5@200643|Bacteroidia,4ASVQ@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_50640_1	237368.SCABRO_01383	7.48e-20	86.3	2C3ZE@1|root,32TE1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_50640_2	426114.THI_1066	2.22e-52	178.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1N9SU@1224|Proteobacteria,2VI30@28216|Betaproteobacteria,1KIV1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_765825_1	945713.IALB_2662	2.83e-86	281.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT,PMT_2,TPR_19
k59_243548_2	1379698.RBG1_1C00001G1725	8.72e-103	327.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD	-	-	ko:K03296,ko:K18138,ko:K18307	ko01501,ko01503,ko02024,map01501,map01503,map02024	M00644,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.20,2.A.6.2.32	-	-	ACR_tran
k59_50647_1	330214.NIDE3884	2.72e-91	279.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	sorA	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_344464_1	573413.Spirs_0268	5.68e-73	224.0	COG0252@1|root,COG0252@2|Bacteria	2|Bacteria	EJ	asparaginase activity	aspG	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_765834_1	439235.Dalk_3622	1.56e-91	284.0	COG1418@1|root,COG2268@1|root,COG1418@2|Bacteria,COG2268@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MHS7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_181366_1	589865.DaAHT2_2304	3.16e-17	83.2	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,2MI5Y@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_181366_2	1382305.AZUC01000047_gene1024	5.59e-45	151.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,26DNF@186818|Planococcaceae	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_83925_1	330214.NIDE3773	3.22e-228	652.0	COG1067@1|root,COG1067@2|Bacteria,3J0X2@40117|Nitrospirae	40117|Nitrospirae	O	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_638128_1	395494.Galf_1602	1.13e-68	222.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,44V38@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_533100_1	864051.BurJ1DRAFT_0821	6.17e-14	71.2	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,1KJHW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_533100_2	1288494.EBAPG3_7400	1.55e-40	137.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,373ED@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Sigma 54 modulation protein	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_50658_1	1229909.NSED_09935	1.71e-55	182.0	COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_508272_1	1205680.CAKO01000037_gene1197	3.79e-81	253.0	COG2175@1|root,COG2175@2|Bacteria,1NTZJ@1224|Proteobacteria,2U8WF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	'PFAM Taurine catabolism dioxygenase TauD, TfdA family'	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_866500_1	1040989.AWZU01000031_gene3919	3.73e-43	145.0	COG3415@1|root,COG3415@2|Bacteria,1RJ69@1224|Proteobacteria,2UB2N@28211|Alphaproteobacteria,3JYIE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07499	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_32,HTH_Tnp_IS630,PAX
k59_866500_2	1112214.AHIS01000121_gene1326	2.24e-07	49.3	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2URW3@28211|Alphaproteobacteria,2KA1D@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110
k59_83932_1	641491.DND132_2163	2.3e-50	167.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKYI@28221|Deltaproteobacteria,2MA7Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
k59_736936_1	497321.C664_11295	2.03e-26	109.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,2KU8J@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_736936_2	75379.Tint_2521	3.29e-26	106.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1KJ0U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_1020815_1	933262.AXAM01000005_gene2455	6.65e-157	453.0	COG0232@1|root,COG0232@2|Bacteria,1R6QQ@1224|Proteobacteria,42M0H@68525|delta/epsilon subdivisions,2WJ33@28221|Deltaproteobacteria,2MHN1@213118|Desulfobacterales	28221|Deltaproteobacteria	F	SMART metal-dependent phosphohydrolase HD region	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_996945_1	1096756.ATKN01000019_gene1553	6.41e-09	61.6	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,1W7IB@1268|Micrococcaceae	201174|Actinobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_243567_1	292415.Tbd_2098	1.74e-26	108.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,1KRS8@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Aminomethyltransferase folate-binding domain	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T
k59_965414_1	1131266.ARWQ01000004_gene1479	1.25e-51	176.0	arCOG08650@1|root,arCOG08650@2157|Archaea,41SZ5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_704532_1	358220.C380_23275	4.66e-83	275.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4ABWU@80864|Comamonadaceae	28216|Betaproteobacteria	T	Adenylate cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_932790_1	1231190.NA8A_13570	1.42e-13	71.6	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2TQKZ@28211|Alphaproteobacteria,43IFN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	N	Flagellar motor protein	MA20_18060	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
k59_441822_1	864051.BurJ1DRAFT_2252	7.03e-39	149.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KN6Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	CHASE2	-	-	2.7.13.3	ko:K10715	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE2,HATPase_c,HisKA,Hpt,Response_reg
k59_83946_1	386456.JQKN01000001_gene2254	2.82e-09	60.5	COG2203@1|root,COG3920@1|root,arCOG02350@1|root,arCOG06712@1|root,arCOG07605@1|root,arCOG02335@2157|Archaea,arCOG02350@2157|Archaea,arCOG02356@2157|Archaea,arCOG06712@2157|Archaea,arCOG07605@2157|Archaea,2XW2Z@28890|Euryarchaeota	28890|Euryarchaeota	T	COG0642 Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,PAS,PAS_4,PAS_9
k59_243577_1	391038.Bphy_4585	1.13e-59	201.0	COG3264@1|root,COG3264@2|Bacteria,1QUDC@1224|Proteobacteria,2VJMG@28216|Betaproteobacteria,1K793@119060|Burkholderiaceae	28216|Betaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_406860_2	1132836.RCCGE510_17911	3.42e-24	103.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2TSCV@28211|Alphaproteobacteria,4B7I3@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Major facilitator superfamily	MA20_25070	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_866517_1	1304885.AUEY01000016_gene3047	5.02e-51	173.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,2MI7M@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
k59_148921_1	382464.ABSI01000017_gene56	1.97e-101	303.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	yphC	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	iECW_1372.ECW_m2771,iWFL_1372.ECW_m2771	ADH_N,ADH_zinc_N
k59_83952_1	1279017.AQYJ01000026_gene379	1.14e-138	414.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RR0R@1236|Gammaproteobacteria,469YC@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_508303_1	1000565.METUNv1_02790	5.21e-86	273.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,2KU6I@206389|Rhodocyclales	206389|Rhodocyclales	E	extracellular solute-binding protein	oppA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_315484_1	1292034.OR37_00363	2.03e-63	202.0	COG1024@1|root,COG1024@2|Bacteria,1N4N7@1224|Proteobacteria,2TS6T@28211|Alphaproteobacteria,2KF8D@204458|Caulobacterales	204458|Caulobacterales	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_24852_1	1173020.Cha6605_4495	2.86e-136	407.0	COG5659@1|root,COG5659@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_122469_1	95619.PM1_0205320	1.01e-26	106.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006464,GO:0006479,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0016043,GO:0016740,GO:0016741,GO:0018364,GO:0019222,GO:0019538,GO:0022411,GO:0032259,GO:0032984,GO:0034641,GO:0034645,GO:0036009,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043414,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_382397_2	1385517.N800_04200	1.23e-31	128.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1X3A5@135614|Xanthomonadales	135614|Xanthomonadales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_1023967_1	1232410.KI421428_gene1008	5.98e-61	194.0	COG1122@1|root,COG1122@2|Bacteria,1N5X0@1224|Proteobacteria,43ADF@68525|delta/epsilon subdivisions,2WMEV@28221|Deltaproteobacteria,43T54@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006,ko:K16787	ko02010,map02010	M00245,M00246,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
k59_841634_2	522306.CAP2UW1_1540	3.67e-21	91.7	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,1KPQW@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817	2.3.1.179	ko:K00646,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_187245_1	990073.ATHU01000001_gene1162	1.69e-24	103.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,42MQ3@68525|delta/epsilon subdivisions,2YMPC@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_939282_1	335543.Sfum_3634	6.85e-59	193.0	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,2MQGF@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
k59_514744_1	1313172.YM304_24080	4.59e-11	63.9	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CNF1@84992|Acidimicrobiia	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_514744_2	35754.JNYJ01000024_gene9127	1.04e-15	77.0	COG0778@1|root,COG0778@2|Bacteria,2HI8Q@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1023972_1	1122605.KB893635_gene3498	8.41e-106	327.0	COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,1IQ8E@117747|Sphingobacteriia	976|Bacteroidetes	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
k59_56587_1	1123261.AXDW01000001_gene1046	1.5e-71	225.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,1S2MJ@1236|Gammaproteobacteria,1X6B4@135614|Xanthomonadales	135614|Xanthomonadales	S	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_219799_1	1163617.SCD_n02025	1.44e-124	367.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2VKBR@28216|Betaproteobacteria	28216|Betaproteobacteria	CP	NADH Ubiquinone plastoquinone (Complex I)	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
k59_24868_2	330214.NIDE1029	1.8e-16	80.1	COG1477@1|root,COG1477@2|Bacteria	2|Bacteria	H	protein flavinylation	nosX	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_514751_1	935567.JAES01000003_gene234	1.34e-103	311.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_612067_1	557598.LHK_01829	1.2e-44	151.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,2KPQ6@206351|Neisseriales	206351|Neisseriales	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_612067_3	153948.NAL212_0228	5.59e-82	249.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,3731U@32003|Nitrosomonadales	28216|Betaproteobacteria	L	endonuclease III	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_612067_4	1000565.METUNv1_04029	3.06e-09	58.5	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2VSHR@28216|Betaproteobacteria,2KW1R@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
k59_1023974_1	1218075.BAYA01000006_gene2173	8.3e-18	82.8	COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,2VNPX@28216|Betaproteobacteria,1K0J3@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_971969_1	667014.Thein_0579	1.51e-06	52.8	COG0317@1|root,COG0317@2|Bacteria,2GHKR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_971969_2	1229780.BN381_10342	6.04e-15	68.6	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,3UX04@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Ribosomal L28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_219800_1	671143.DAMO_2139	1.05e-138	405.0	COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_743472_1	1231391.AMZF01000069_gene2125	9.02e-68	219.0	COG2271@1|root,COG2271@2|Bacteria,1QTYR@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_316305_1	1121920.AUAU01000011_gene197	1.62e-79	261.0	COG1372@1|root,COG1573@1|root,COG1372@2|Bacteria,COG1573@2|Bacteria,3Y43G@57723|Acidobacteria	57723|Acidobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_187259_2	1267535.KB906767_gene3605	2.78e-14	70.1	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria	57723|Acidobacteria	K	regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_580124_1	397945.Aave_1174	3.64e-13	68.9	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,4AA5K@80864|Comamonadaceae	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_580124_2	1348657.M622_02415	1.18e-109	344.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,2KV38@206389|Rhodocyclales	206389|Rhodocyclales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1023977_1	765910.MARPU_10305	5.96e-74	228.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1WW35@135613|Chromatiales	135613|Chromatiales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_711109_1	1121004.ATVC01000055_gene614	2.01e-16	79.3	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,2KQBE@206351|Neisseriales	206351|Neisseriales	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_711109_2	1121439.dsat_2850	8.62e-49	163.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,42NFH@68525|delta/epsilon subdivisions,2WITT@28221|Deltaproteobacteria,2M8DG@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_219813_1	522306.CAP2UW1_0930	2.65e-43	160.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,1KPUH@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_350772_2	1121921.KB898706_gene2708	9.89e-61	197.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,2PMNS@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	D-ala D-ala ligase N-terminus	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_477409_1	1294143.H681_00310	2.05e-10	63.5	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	protein containing LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_477409_2	987059.RBXJA2T_06210	2.48e-06	49.7	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,1KK7C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	LU	TIGRFAM DNA protecting protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_24891_1	1123257.AUFV01000001_gene1646	6.9e-63	214.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1X4C5@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_971986_1	706587.Desti_3109	6.75e-24	98.6	COG0455@1|root,COG0455@2|Bacteria,1MW3G@1224|Proteobacteria,42NA9@68525|delta/epsilon subdivisions,2WKEE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	GSCFA family	-	-	-	-	-	-	-	-	-	-	-	-	GSCFA
k59_971986_2	439235.Dalk_0577	5.97e-19	85.1	COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,42MDW@68525|delta/epsilon subdivisions,2WKQK@28221|Deltaproteobacteria,2MHSY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
k59_872763_1	713587.THITH_02440	3.9e-37	137.0	COG3642@1|root,COG3642@2|Bacteria,1RDW7@1224|Proteobacteria,1S46R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position	kdkA	-	2.7.1.166	ko:K11211	ko00540,map00540	-	R09767	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Kdo
k59_678323_1	1229909.NSED_03355	6.04e-79	262.0	COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota	651137|Thaumarchaeota	D	SMC proteins Flexible Hinge Domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_447931_1	945713.IALB_0708	1.08e-27	106.0	COG0194@1|root,COG0194@2|Bacteria	2|Bacteria	F	guanylate kinase activity	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8,4.1.1.23	ko:K00942,ko:K01591	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00050,M00051	R00332,R00965,R02090	RC00002,RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193	Guanylate_kin
k59_219823_1	113395.AXAI01000041_gene6360	9.84e-58	194.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,3JW5N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_971994_2	1394178.AWOO02000046_gene6514	1.48e-27	110.0	COG0657@1|root,COG0657@2|Bacteria,2I6Z1@201174|Actinobacteria	201174|Actinobacteria	I	Esterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_711125_1	1121004.ATVC01000032_gene2216	7.85e-70	218.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,2KQ6D@206351|Neisseriales	206351|Neisseriales	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_939328_1	1118054.CAGW01000065_gene2038	4.12e-66	218.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,4HA3U@91061|Bacilli,26RTX@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_90504_1	1248760.ANFZ01000007_gene2883	2.5e-22	95.9	COG1309@1|root,COG1309@2|Bacteria,1PDZ8@1224|Proteobacteria,2UC3D@28211|Alphaproteobacteria,2K77N@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_3,TetR_N
k59_971996_2	1049564.TevJSym_bb00030	3.61e-20	97.1	COG1013@1|root,COG1013@2|Bacteria,1R28U@1224|Proteobacteria	1224|Proteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
k59_382451_1	936136.ARRT01000006_gene2139	1.79e-116	348.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria,4BAZE@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_447944_1	1472716.KBK24_0108845	1.73e-102	319.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,1K1ZS@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_939329_1	477184.KYC_08795	1.75e-130	400.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,3T74P@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig
k59_316341_1	358681.BBR47_19970	1.44e-10	63.5	COG1555@1|root,COG1596@1|root,COG1555@2|Bacteria,COG1596@2|Bacteria,1VA3W@1239|Firmicutes,4HKJ1@91061|Bacilli,26X94@186822|Paenibacillaceae	91061|Bacilli	L	DNA uptake protein and related DNA-binding proteins	comEA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
k59_477438_1	1247963.JPHU01000008_gene2877	4.78e-93	287.0	COG0446@1|root,COG0446@2|Bacteria,1Q0P8@1224|Proteobacteria,2U4CV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Tryptophan halogenase	-	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
k59_90520_1	1123269.NX02_06260	9.9e-87	270.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,2K04G@204457|Sphingomonadales	204457|Sphingomonadales	C	Methylmalonate-semialdehyde dehydrogenase	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_24922_1	396588.Tgr7_0524	2.98e-24	108.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales	135613|Chromatiales	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
k59_972010_1	1353529.M899_2978	8.11e-15	75.9	COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,42QQ8@68525|delta/epsilon subdivisions,2MSNG@213481|Bdellovibrionales,2WMX3@28221|Deltaproteobacteria	213481|Bdellovibrionales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_278755_1	1229909.NSED_02265	3.26e-47	155.0	COG1382@1|root,arCOG01342@2157|Archaea,41SPD@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
k59_447959_1	591167.Sfla_1189	2.66e-25	108.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_678355_1	1120966.AUBU01000006_gene3240	1.49e-29	115.0	COG4974@1|root,COG4974@2|Bacteria,4NMH3@976|Bacteroidetes	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_5,Phage_int_SAM_5,Phage_integrase
k59_678355_2	1150600.ADIARSV_3501	0.000479	43.5	COG0640@1|root,COG0640@2|Bacteria,4PN0I@976|Bacteroidetes,1ITFH@117747|Sphingobacteriia	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
k59_24928_1	1484460.JSWG01000001_gene2205	1.73e-54	182.0	COG4313@1|root,COG4313@2|Bacteria,4NS24@976|Bacteroidetes,1I03V@117743|Flavobacteriia	976|Bacteroidetes	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_514814_2	1230476.C207_01865	3.56e-133	390.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,3JWE8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_477447_1	396588.Tgr7_2474	3.06e-39	138.0	COG0121@1|root,COG0121@2|Bacteria,1PX9X@1224|Proteobacteria,1SBGN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glutamine amidotransferase	egtC	-	-	-	-	-	-	-	-	-	-	-	GATase_4
k59_644518_2	675813.VIB_000196	1.92e-28	105.0	COG3436@1|root,COG3436@2|Bacteria,1N638@1224|Proteobacteria,1SFHC@1236|Gammaproteobacteria,1Y280@135623|Vibrionales	1236|Gammaproteobacteria	L	IS66 Orf2 like protein	-	-	-	-	-	-	-	-	-	-	-	-	TnpB_IS66
k59_841727_1	870187.Thini_4004	1.57e-104	313.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,4607K@72273|Thiotrichales	72273|Thiotrichales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_316360_1	1121434.AULY01000006_gene567	5.8e-10	60.1	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42M8D@68525|delta/epsilon subdivisions,2WJ6E@28221|Deltaproteobacteria,2M8I0@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C,Fer2_BFD
k59_316360_2	406552.NJ7G_1716	6.81e-19	92.4	COG3075@1|root,arCOG04585@2157|Archaea,2XU2M@28890|Euryarchaeota,23T8G@183963|Halobacteria	183963|Halobacteria	E	COG3075 Anaerobic glycerol-3-phosphate dehydrogenase	glpB	-	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
k59_350821_1	330214.NIDE1804	2.12e-195	574.0	COG3696@1|root,COG3696@2|Bacteria,3J0ZR@40117|Nitrospirae	40117|Nitrospirae	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_278763_1	66869.JNXG01000029_gene865	1.08e-19	90.9	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,41CPU@629295|Streptomyces griseus group	201174|Actinobacteria	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_122572_1	864051.BurJ1DRAFT_2040	2.15e-74	225.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2W9FK@28216|Betaproteobacteria,1KKMT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_122572_2	395495.Lcho_2514	7.58e-11	61.2	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1KK4D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_477452_1	1265505.ATUG01000001_gene3405	2.58e-18	90.1	COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N,YbbR
k59_514823_1	997829.HMPREF1121_00236	5.85e-41	152.0	COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,2FM3F@200643|Bacteroidia,22X7T@171551|Porphyromonadaceae	976|Bacteroidetes	M	alginate O-acetyltransferase	algI	-	-	-	-	-	-	-	-	-	-	-	MBOAT
k59_447984_1	103372.F4X663	2.88e-27	113.0	2AAKT@1|root,2RYMC@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_24952_1	1408224.SAMCCGM7_c2373	1.29e-93	280.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,4BDFW@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_25950_2	945713.IALB_0013	7.85e-36	135.0	COG0445@1|root,COG0445@2|Bacteria	2|Bacteria	D	tRNA wobble uridine modification	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_63509_1	395965.Msil_1082	3.63e-08	56.2	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2U7G6@28211|Alphaproteobacteria,3NACU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_358055_1	1472716.KBK24_0108045	1.52e-71	233.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,1JZP5@119060|Burkholderiaceae	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_587615_1	247490.KSU1_B0209	1.83e-49	174.0	COG4467@1|root,COG4467@2|Bacteria,2J4XJ@203682|Planctomycetes	203682|Planctomycetes	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_879691_2	396588.Tgr7_0341	5.58e-29	108.0	COG0622@1|root,COG0622@2|Bacteria,1RCUQ@1224|Proteobacteria,1S2YE@1236|Gammaproteobacteria,1WY1W@135613|Chromatiales	135613|Chromatiales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
k59_619135_1	1042375.AFPL01000026_gene3760	1.75e-26	115.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1T1I1@1236|Gammaproteobacteria,46CYF@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_9
k59_32120_1	436308.Nmar_0537	3.59e-90	276.0	COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota	651137|Thaumarchaeota	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
k59_97872_1	1191523.MROS_2026	2.04e-60	208.0	COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N,Response_reg,SpoIIE
k59_162246_1	1379858.N508_01119	1.41e-35	133.0	COG0739@1|root,COG0739@2|Bacteria,2GF3Z@200930|Deferribacteres	200930|Deferribacteres	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_97883_1	1298880.AUEV01000015_gene53	3.19e-33	129.0	COG0620@1|root,COG0620@2|Bacteria,2I9RI@201174|Actinobacteria	201174|Actinobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_97883_2	1348662.CARG_02785	6.95e-08	54.3	COG1309@1|root,COG1309@2|Bacteria,2I8NQ@201174|Actinobacteria,22JVZ@1653|Corynebacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	amtR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_483477_1	765911.Thivi_0995	8.45e-98	293.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1WWXU@135613|Chromatiales	135613|Chromatiales	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_32160_1	1121861.KB899930_gene218	3.04e-44	155.0	COG0697@1|root,COG0697@2|Bacteria,1R81I@1224|Proteobacteria,2VFWV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_879736_2	107636.JQNK01000002_gene369	8.49e-08	55.1	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,36ZW1@31993|Methylocystaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_389432_1	243233.MCA0712	4.28e-42	155.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1XEC9@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
k59_389432_2	937774.TEQUI_1347	3.49e-07	53.5	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VM32@28216|Betaproteobacteria,3T3S1@506|Alcaligenaceae	28216|Betaproteobacteria	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_946684_1	1254432.SCE1572_25730	1.11e-42	157.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,42M92@68525|delta/epsilon subdivisions,2WJ7J@28221|Deltaproteobacteria,2YVBA@29|Myxococcales	28221|Deltaproteobacteria	M	PFAM MscS Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_389440_1	1382356.JQMP01000001_gene957	0.00023	50.1	COG0477@1|root,COG2814@2|Bacteria,2G6UA@200795|Chloroflexi,27YWF@189775|Thermomicrobia	189775|Thermomicrobia	EGP	Sugar (and other) transporter	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_454865_1	1232410.KI421428_gene975	3.48e-09	55.8	COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,42TMF@68525|delta/epsilon subdivisions,2WQNM@28221|Deltaproteobacteria,43V35@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Cobinamide kinase / cobinamide phosphate guanyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
k59_454865_2	1121937.AUHJ01000004_gene1013	4.39e-114	340.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1T7KM@1236|Gammaproteobacteria,46C37@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_226742_1	1123401.JHYQ01000009_gene2300	9.35e-27	105.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,45ZUF@72273|Thiotrichales	72273|Thiotrichales	S	PFAM AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,CbbQ_C
k59_255406_1	414684.RC1_0236	1.17e-84	266.0	COG3573@1|root,COG3573@2|Bacteria,1R00Y@1224|Proteobacteria	1224|Proteobacteria	C	FAD dependent oxidoreductase	-	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_522425_1	266117.Rxyl_0315	1.88e-101	322.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2GIV1@201174|Actinobacteria,4CPAY@84995|Rubrobacteria	84995|Rubrobacteria	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_795149_1	1276756.AUEX01000004_gene2352	3.49e-33	131.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,4AAAJ@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig
k59_162283_1	883078.HMPREF9695_00228	9.68e-51	172.0	COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,2U255@28211|Alphaproteobacteria,3JX87@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_619190_1	305700.B447_11472	2.61e-79	260.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,2KVUW@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
k59_226755_1	272630.MexAM1_META1p5144	4.7e-05	50.1	COG3827@1|root,COG3827@2|Bacteria,1MX61@1224|Proteobacteria,2TSG8@28211|Alphaproteobacteria,1JUK2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2497)	-	-	-	ko:K09991	-	-	-	-	ko00000	-	-	-	DUF2497
k59_979510_1	331869.BAL199_29922	8.98e-71	219.0	COG5553@1|root,COG5553@2|Bacteria,1RD6A@1224|Proteobacteria,2U7HF@28211|Alphaproteobacteria,4BT3J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent enzyme of the double-stranded beta helix superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_619197_1	221288.JH992901_gene2033	1.69e-05	50.8	COG2199@1|root,COG4252@1|root,COG2199@2|Bacteria,COG4252@2|Bacteria,1G17N@1117|Cyanobacteria,1JHUD@1189|Stigonemataceae	1117|Cyanobacteria	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,GGDEF,PAS,PAS_4
k59_979515_1	59538.XP_005974298.1	3.46e-78	250.0	COG0513@1|root,KOG0331@2759|Eukaryota,39Q3Q@33154|Opisthokonta,3CQZA@33208|Metazoa,3E74N@33213|Bilateria,48SPK@7711|Chordata,49P7B@7742|Vertebrata,3JP3Z@40674|Mammalia	59538.XP_005974298.1|-	A	DEAD-box ATP-dependent RNA helicase 14-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_454894_1	933262.AXAM01000015_gene72	1.52e-22	96.3	2EB4V@1|root,3355H@2|Bacteria,1NDVZ@1224|Proteobacteria,42VK3@68525|delta/epsilon subdivisions,2WSEC@28221|Deltaproteobacteria,2MM22@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_587718_1	637389.Acaty_c2281	7.63e-112	344.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales	225057|Acidithiobacillales	P	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_226773_1	1123242.JH636435_gene2937	8.39e-27	108.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
k59_226773_2	1320556.AVBP01000011_gene3413	7.91e-18	80.9	COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,2U3NC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1009962_1	485913.Krac_0916	1.44e-70	235.0	COG1961@1|root,COG1961@2|Bacteria,2G7BH@200795|Chloroflexi	200795|Chloroflexi	L	COGs COG1961 Site-specific recombinase DNA invertase Pin homologs	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_911307_1	330214.NIDE0991	9.41e-31	118.0	COG1579@1|root,COG1579@2|Bacteria,3J0UV@40117|Nitrospirae	40117|Nitrospirae	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
k59_282638_1	1121957.ATVL01000008_gene4404	2.38e-29	118.0	COG4953@1|root,COG4953@2|Bacteria,4NEG5@976|Bacteroidetes,47KYC@768503|Cytophagia	976|Bacteroidetes	M	penicillin-binding protein 1C	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
k59_619224_1	159087.Daro_3475	1.54e-80	246.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2VIN7@28216|Betaproteobacteria,2KU9A@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_879791_1	349521.HCH_05304	9.38e-104	315.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1XH6X@135619|Oceanospirillales	135619|Oceanospirillales	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1027742_1	1304875.JAFZ01000001_gene945	5.44e-62	203.0	COG0786@1|root,COG0786@2|Bacteria,3TA78@508458|Synergistetes	508458|Synergistetes	E	glutamate:sodium symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_619231_1	748247.AZKH_4217	2.08e-12	68.9	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,2KUHK@206389|Rhodocyclales	206389|Rhodocyclales	U	Type 4 fimbrial biogenesis protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_619231_2	946483.Cenrod_1487	7.18e-17	79.3	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,2VSVR@28216|Betaproteobacteria,4ADYU@80864|Comamonadaceae	28216|Betaproteobacteria	NU	Pilus assembly protein	pilP	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_454930_1	1122134.KB893650_gene1522	4.38e-66	219.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1XHDI@135619|Oceanospirillales	135619|Oceanospirillales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_358225_1	743299.Acife_2330	5.6e-40	147.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,1SDJ1@1236|Gammaproteobacteria,2NDQ9@225057|Acidithiobacillales	225057|Acidithiobacillales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_879808_1	1288494.EBAPG3_24650	3.33e-59	192.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,2VS5T@28216|Betaproteobacteria,373UT@32003|Nitrosomonadales	28216|Betaproteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1027748_1	1123487.KB892867_gene892	1.54e-82	258.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KVE6@206389|Rhodocyclales	206389|Rhodocyclales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Sigma54_activat
k59_879812_1	765910.MARPU_13540	6.13e-64	216.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_226812_1	1304872.JAGC01000009_gene18	9.4e-30	110.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MGUH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_651523_1	1123288.SOV_2c08540	1.04e-43	148.0	COG1014@1|root,COG1014@2|Bacteria,1V3RG@1239|Firmicutes,4H40M@909932|Negativicutes	909932|Negativicutes	C	2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_322986_1	714961.BFZC1_12433	1.25e-23	98.6	COG0492@1|root,COG0492@2|Bacteria,1TRPN@1239|Firmicutes,4HACJ@91061|Bacilli,3IWF5@400634|Lysinibacillus	91061|Bacilli	C	reductase	-	-	1.18.1.2,1.19.1.1	ko:K21567	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_322986_2	983920.Y88_1933	2.56e-16	78.2	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,2K0DQ@204457|Sphingomonadales	204457|Sphingomonadales	S	2-nitropropane dioxygenase	-	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO,ThiG
k59_129887_1	290397.Adeh_0531	6.21e-22	99.4	COG1752@1|root,COG1752@2|Bacteria,1N9HS@1224|Proteobacteria	1224|Proteobacteria	S	Patatin-like phospholipase	suhR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Patatin
k59_255472_1	926569.ANT_06340	6.2e-22	92.4	COG1086@1|root,COG1086@2|Bacteria,2G8BP@200795|Chloroflexi	200795|Chloroflexi	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_2
k59_255472_2	926569.ANT_06330	8.54e-28	108.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_911347_1	1000565.METUNv1_00837	9.67e-124	367.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,2KVE3@206389|Rhodocyclales	206389|Rhodocyclales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_911347_2	1203554.HMPREF1476_00334	7e-08	53.9	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,4PQ9U@995019|Sutterellaceae	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_483563_1	1266925.JHVX01000001_gene2622	2.39e-47	166.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2VNED@28216|Betaproteobacteria,37285@32003|Nitrosomonadales	28216|Betaproteobacteria	L	TIGRFAM DNA polymerase III, delta prime subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_255477_1	557598.LHK_02085	3.7e-39	138.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2VPKX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome c-type protein	napC	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
k59_912297_1	1366050.N234_06785	1.96e-63	218.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria,1K20Q@119060|Burkholderiaceae	28216|Betaproteobacteria	E	NAD-glutamate dehydrogenase	gdhB	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_778940_1	1125863.JAFN01000001_gene2939	4.43e-34	131.0	COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria	1224|Proteobacteria	F	Adenylate cyclase	-	-	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	Adenyl_cycl_N,Adenylate_cycl,Pentapeptide,Pentapeptide_4
k59_778940_2	869210.Marky_1036	3.74e-11	60.5	COG3350@1|root,COG3350@2|Bacteria,1WN5Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
k59_195584_1	864051.BurJ1DRAFT_2972	4.99e-114	353.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,1KJXP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_227878_1	177437.HRM2_32970	7.45e-67	224.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2MIIX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Elongation factor SelB winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_283195_1	76114.ebA1185	2.91e-64	212.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,2KUH8@206389|Rhodocyclales	206389|Rhodocyclales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groEL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_620287_1	330214.NIDE0972	9.27e-127	362.0	COG0226@1|root,COG0226@2|Bacteria,3J0YH@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	-	-	-	-	-	-	-	-	-	CO_dh
k59_620287_2	330214.NIDE0971	6.77e-44	152.0	COG0674@1|root,COG0674@2|Bacteria,3J0WN@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_283197_1	926559.JoomaDRAFT_3436	0.00087	41.2	COG1250@1|root,COG1250@2|Bacteria,4NGU8@976|Bacteroidetes,1HWQX@117743|Flavobacteriia	976|Bacteroidetes	I	Dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_283197_2	717785.HYPMC_3540	8.85e-49	170.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRI3@28211|Alphaproteobacteria,3N6BQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.67	ko:K00128,ko:K21802	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00627,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00627,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05699,R06366,R08146	RC00047,RC00071,RC00075,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_880832_1	626887.J057_12501	3.91e-20	93.2	COG3138@1|root,COG3138@2|Bacteria,1MWHC@1224|Proteobacteria,1RMXG@1236|Gammaproteobacteria,469DX@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG3138 Arginine ornithine N-succinyltransferase beta subunit	astA	-	2.3.1.109	ko:K00673	ko00330,ko01100,map00330,map01100	-	R00832	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_1875	AstA
k59_324042_1	1206731.BAGB01000041_gene8378	9.46e-33	127.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4FWXS@85025|Nocardiaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
k59_390780_1	202955.BBND01000018_gene1805	1.16e-13	69.7	COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,1S95S@1236|Gammaproteobacteria,3NPJV@468|Moraxellaceae	1236|Gammaproteobacteria	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
k59_390780_2	1131730.BAVI_05064	2.31e-07	54.3	COG0477@1|root,COG2814@2|Bacteria,1V1FR@1239|Firmicutes,4HGHP@91061|Bacilli,1ZGSN@1386|Bacillus	91061|Bacilli	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_195616_1	1177181.T9A_01402	3.38e-42	145.0	COG4659@1|root,COG4659@2|Bacteria,1MZVX@1224|Proteobacteria,1S9KJ@1236|Gammaproteobacteria,1XQ3F@135619|Oceanospirillales	135619|Oceanospirillales	C	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
k59_494820_1	330214.NIDE4242	1.31e-81	256.0	COG1160@1|root,COG1160@2|Bacteria,3J0G3@40117|Nitrospirae	40117|Nitrospirae	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	engA	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_168109_1	395492.Rleg2_4409	6.99e-38	142.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria,4B700@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve
k59_37517_1	443598.AUFA01000051_gene26	3.23e-24	107.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_298316_2	864051.BurJ1DRAFT_2327	2.15e-26	108.0	COG3107@1|root,COG3107@2|Bacteria,1NBKY@1224|Proteobacteria,2VXD7@28216|Betaproteobacteria,1KNHB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	peptidoglycan biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_658009_1	1499967.BAYZ01000177_gene5710	7.28e-39	134.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
k59_690626_1	1316936.K678_06607	1.09e-82	274.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,2JRE2@204441|Rhodospirillales	204441|Rhodospirillales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_690632_2	1380394.JADL01000004_gene5741	5.95e-100	295.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2JQE0@204441|Rhodospirillales	204441|Rhodospirillales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_821232_1	257310.BB1585	6.29e-70	223.0	COG0697@1|root,COG0697@2|Bacteria,1MV7Y@1224|Proteobacteria,2VR8Q@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_919185_1	1236976.JCM16418_2927	3.22e-48	166.0	COG0702@1|root,COG0702@2|Bacteria,1VSFK@1239|Firmicutes,4HU1A@91061|Bacilli,26VE1@186822|Paenibacillaceae	91061|Bacilli	GM	NAD-dependent dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_331267_1	945713.IALB_2956	1.06e-121	358.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	-	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_723171_1	630626.EBL_c27870	4.79e-67	225.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RMII@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	namA	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
k59_70318_1	153948.NAL212_2235	2.6e-95	307.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,371WK@32003|Nitrosomonadales	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_4865_1	933262.AXAM01000034_gene1557	1.17e-96	298.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_951585_1	1144307.PMI04_01226	3.75e-40	150.0	COG1680@1|root,COG1680@2|Bacteria,1PQ2Z@1224|Proteobacteria,2U1GN@28211|Alphaproteobacteria,2K210@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_853426_2	296591.Bpro_3450	2.37e-95	291.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2VHUR@28216|Betaproteobacteria,4AJWR@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k59_168136_1	204773.HEAR1405	9.21e-52	176.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,4725J@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_168136_2	62928.azo3487	2.46e-39	137.0	COG0746@1|root,COG0746@2|Bacteria,1QVCV@1224|Proteobacteria,2WGQQ@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Protein of unknown function (DUF3305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3305
k59_821246_2	1123354.AUDR01000015_gene273	9.26e-51	171.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,1KRZ5@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Dihydroorotate dehydrogenase	-	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_232670_1	1304883.KI912532_gene1328	2.13e-46	166.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,2KVAI@206389|Rhodocyclales	206389|Rhodocyclales	H	enzyme of heme biosynthesis	hemY	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N
k59_168138_1	640081.Dsui_0513	1.15e-25	111.0	COG2199@1|root,COG2199@2|Bacteria,1QTT5@1224|Proteobacteria,2VKM3@28216|Betaproteobacteria,2KY09@206389|Rhodocyclales	206389|Rhodocyclales	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
k59_754856_1	1487953.JMKF01000041_gene3125	3.83e-76	244.0	COG3119@1|root,COG3119@2|Bacteria,1G9TI@1117|Cyanobacteria	1117|Cyanobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_331283_1	1000565.METUNv1_01868	1.62e-201	576.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,2KUNY@206389|Rhodocyclales	206389|Rhodocyclales	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_232674_1	765913.ThidrDRAFT_2347	3.92e-101	298.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
k59_560054_1	1125863.JAFN01000001_gene912	5.45e-59	206.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_135555_1	864051.BurJ1DRAFT_2478	2.7e-64	214.0	COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,2VIR7@28216|Betaproteobacteria,1KJ2P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	lytic transglycosylase	mltD	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_592555_1	1232410.KI421426_gene1331	8.41e-94	295.0	COG0070@1|root,COG0493@1|root,COG1145@1|root,COG0070@2|Bacteria,COG0493@2|Bacteria,COG1145@2|Bacteria,1PBEZ@1224|Proteobacteria,42NFW@68525|delta/epsilon subdivisions,2WIQE@28221|Deltaproteobacteria,43TK8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3,ThiF
k59_395916_1	96561.Dole_0426	2.14e-108	333.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2MHU3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,sCache_3_2
k59_102874_1	1190603.AJYD01000022_gene369	2.25e-94	290.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN8T@1236|Gammaproteobacteria,1XXVY@135623|Vibrionales	135623|Vibrionales	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_102874_2	643473.KB235930_gene1344	1.71e-50	169.0	COG3001@1|root,COG3001@2|Bacteria,1G040@1117|Cyanobacteria,1HIFG@1161|Nostocales	1117|Cyanobacteria	G	PFAM Fructosamine kinase	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_951635_1	1123393.KB891326_gene163	3.2e-95	288.0	COG0169@1|root,COG0169@2|Bacteria,1QWHD@1224|Proteobacteria,2WH08@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
k59_560080_1	420662.Mpe_A3181	1.5e-145	418.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,1KJTP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
k59_526495_1	331869.BAL199_18238	1.02e-74	230.0	COG4977@1|root,COG4977@2|Bacteria,1QUTN@1224|Proteobacteria,2TW75@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
k59_526495_2	479435.Kfla_2117	1.92e-24	102.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4DSZJ@85009|Propionibacteriales	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_592580_1	1485544.JQKP01000013_gene1809	2.25e-108	318.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,44VK5@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Bacterial transferase hexapeptide (six repeats)	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
k59_363777_1	766499.C357_02751	4.85e-24	97.4	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_363777_2	1125863.JAFN01000001_gene3237	1.61e-68	215.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1716	ECH_1
k59_885898_1	933262.AXAM01000053_gene2711	6.07e-89	276.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MIPI@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM carboxyl transferase	-	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_659082_1	1223542.GM1_003_01660	3.54e-17	84.0	COG5361@1|root,COG5361@2|Bacteria,2GKTA@201174|Actinobacteria,4GBT8@85026|Gordoniaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_233543_1	331869.BAL199_06826	5.19e-28	111.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,2TSGQ@28211|Alphaproteobacteria,4BQSJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF374)	MA20_05800	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
k59_169171_1	1121440.AUMA01000009_gene749	2.37e-24	102.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2M8ZX@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_136577_1	1380358.JADJ01000007_gene3155	2.05e-18	85.1	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1XH9W@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_136577_2	1411123.JQNH01000001_gene2397	5.2e-80	246.0	COG1173@1|root,COG1173@2|Bacteria,1MVER@1224|Proteobacteria,2TRB3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_822306_1	1040983.AXAE01000030_gene6202	3.6e-17	85.5	COG3745@1|root,COG3745@2|Bacteria,1MYVE@1224|Proteobacteria,2U7QC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Pilus assembly protein CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
k59_364725_1	1232410.KI421413_gene517	5.82e-50	179.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,43RX8@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Translation-initiation factor 2	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_755716_1	1121035.AUCH01000016_gene2143	4.89e-60	197.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,2KUZZ@206389|Rhodocyclales	206389|Rhodocyclales	T	Signal transduction histidine kinase, nitrogen specific	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_233545_1	926569.ANT_10660	1.67e-91	291.0	COG0495@1|root,COG0495@2|Bacteria,2G5MX@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_691716_1	316057.RPD_0991	1.98e-20	90.9	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,3JTE3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_691716_2	1144342.PMI40_01782	1.39e-19	88.6	COG1804@1|root,COG1804@2|Bacteria,1MU4A@1224|Proteobacteria,2VKDA@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	frc_3	-	2.8.3.22	ko:K18289	ko00660,map00660	-	R02407,R03154	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_transf_3
k59_136592_1	449447.MAE_60950	6.05e-72	235.0	COG5433@1|root,COG5433@2|Bacteria,1G3Z6@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_593593_1	477974.Daud_0639	1.38e-36	136.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,260BR@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_103886_1	266265.Bxe_C1199	3.81e-98	289.0	COG3385@1|root,COG3385@2|Bacteria,1NJ4V@1224|Proteobacteria,2W7RP@28216|Betaproteobacteria,1KF14@119060|Burkholderiaceae	28216|Betaproteobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_169191_1	987059.RBXJA2T_03456	9.02e-83	256.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2VJ31@28216|Betaproteobacteria,1KKBT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_169191_2	596154.Alide2_1546	1.45e-08	55.8	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,4ABKZ@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_593597_1	987059.RBXJA2T_08365	1.68e-41	144.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2VHTZ@28216|Betaproteobacteria,1KJT0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_593597_2	999541.bgla_2p0900	4.63e-17	79.0	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,2VUGI@28216|Betaproteobacteria,1K28F@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	imuA	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	-
k59_920269_1	571166.KI421509_gene1121	2.98e-28	118.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_201733_1	983917.RGE_32230	6.27e-63	208.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1KK2E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
k59_364756_2	1163617.SCD_n02026	2.61e-62	205.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2VJ0R@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	hyfG	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
k59_332351_1	944481.JAFP01000001_gene919	4.22e-132	386.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2M6PH@213113|Desulfurellales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_626133_1	1123073.KB899241_gene2898	1.7e-61	213.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1X4W6@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
k59_626133_2	1123253.AUBD01000010_gene2125	8e-16	75.9	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1X4DA@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_136620_1	945713.IALB_1132	1.46e-74	226.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_136620_2	945713.IALB_0026	4e-118	345.0	COG1830@1|root,COG1830@2|Bacteria	2|Bacteria	G	lyase activity	fbaB	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_2236,iSBO_1134.SBO_0918,iUMNK88_1353.UMNK88_2640	DeoC
k59_755750_1	265072.Mfla_0299	2.18e-158	455.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,2KKX5@206350|Nitrosomonadales	206350|Nitrosomonadales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_529902_2	1217712.F971_03118	1.15e-11	63.9	2DHD0@1|root,2ZZ9M@2|Bacteria,1PWCV@1224|Proteobacteria,1RVRY@1236|Gammaproteobacteria,3NS85@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_566726_1	983917.RGE_40720	1.96e-32	127.0	COG4206@1|root,COG4206@2|Bacteria,1QUWU@1224|Proteobacteria,2WGQG@28216|Betaproteobacteria	28216|Betaproteobacteria	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_566727_2	864051.BurJ1DRAFT_3852	4.83e-76	234.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,1KKT8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0234 family	yajQ	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_174773_1	1203605.HMPREF1531_02091	6.83e-24	100.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4DWGD@85009|Propionibacteriales	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
k59_566730_2	1150474.JQJI01000007_gene263	4.23e-20	88.6	COG0105@1|root,COG2199@1|root,COG0105@2|Bacteria,COG3706@2|Bacteria,2GCWQ@200918|Thermotogae	200918|Thermotogae	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_466399_1	94624.Bpet0551	1.74e-84	257.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2VHSP@28216|Betaproteobacteria,3T354@506|Alcaligenaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	abmC	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_466399_2	1144343.PMI41_02922	2.36e-14	73.9	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria,43J1N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_304486_1	1205680.CAKO01000010_gene3810	8.15e-66	227.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_237982_1	378806.STAUR_4939	2.65e-15	75.5	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42NGK@68525|delta/epsilon subdivisions,2WM29@28221|Deltaproteobacteria,2YU1M@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2768	NTP_transferase
k59_237982_2	1265502.KB905947_gene1095	9.11e-09	57.8	COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2VKTC@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_272156_1	438753.AZC_2350	2.03e-74	231.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,3EZCC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	MA20_16895	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_272156_2	1499967.BAYZ01000118_gene3277	1.12e-121	360.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
k59_859894_1	1223545.GS4_34_00510	2.08e-12	67.4	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4GCCZ@85026|Gordoniaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_859894_2	685727.REQ_17230	8.96e-11	61.6	COG1846@1|root,COG1846@2|Bacteria,2GKZA@201174|Actinobacteria,4FUFE@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_566745_1	1532557.JL37_12310	7.27e-19	85.9	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,3T2I4@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_401264_1	522306.CAP2UW1_0488	1.37e-120	362.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2VHAK@28216|Betaproteobacteria,1KQGW@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_11777_1	926569.ANT_23450	5.26e-80	249.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_631589_1	1229909.NSED_01005	7.09e-91	269.0	COG0586@1|root,arCOG03117@2157|Archaea,41SQ5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_529919_1	314278.NB231_13251	1.72e-20	89.7	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RCFZ@1224|Proteobacteria,1S2QS@1236|Gammaproteobacteria,1X1B9@135613|Chromatiales	135613|Chromatiales	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_529919_2	1057002.KB905371_gene120	2.76e-56	182.0	COG3415@1|root,COG3415@2|Bacteria,1RDMQ@1224|Proteobacteria,2U6V9@28211|Alphaproteobacteria,4BEPN@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	protein y4pG y4sC	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,HTH_33
k59_566759_1	595537.Varpa_5974	8.04e-07	50.1	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,4AB6C@80864|Comamonadaceae	28216|Betaproteobacteria	G	Belongs to the transketolase family	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_566759_2	1123393.KB891331_gene2910	5.29e-74	230.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,1KSHN@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_466424_1	1229909.NSED_01410	2.96e-75	227.0	COG0456@1|root,arCOG00833@2157|Archaea,41SIY@651137|Thaumarchaeota	651137|Thaumarchaeota	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
k59_238007_1	402881.Plav_1061	4.27e-39	144.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,1JNM7@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_337882_1	1163617.SCD_n01546	1.07e-61	200.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_566776_1	1163617.SCD_n01896	1.31e-41	153.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_566776_2	573413.Spirs_3714	4.44e-10	64.3	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_828137_1	1232410.KI421413_gene800	3.15e-33	117.0	COG0268@1|root,COG0268@2|Bacteria,1NITA@1224|Proteobacteria,42V4U@68525|delta/epsilon subdivisions,2WR9I@28221|Deltaproteobacteria,43SS9@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein S20	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_207167_1	1266925.JHVX01000003_gene527	6.42e-86	263.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,371UG@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_1018050_1	438753.AZC_3212	4.22e-36	136.0	COG1250@1|root,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2TRAW@28211|Alphaproteobacteria,3F0R2@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_175727_1	1541065.JRFE01000012_gene2421	0.000132	43.5	COG2220@1|root,COG2220@2|Bacteria,1G2CA@1117|Cyanobacteria,3VMCR@52604|Pleurocapsales	1117|Cyanobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_175727_2	670292.JH26_12705	2.46e-80	254.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_23605	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_238710_1	933262.AXAM01000005_gene2472	1.14e-09	58.5	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42YHK@68525|delta/epsilon subdivisions,2WUDF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_238710_2	379731.PST_3286	6.46e-09	57.8	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNR@1236|Gammaproteobacteria,1Z0N8@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_208070_1	436308.Nmar_1070	2.82e-93	286.0	COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_991287_1	1121035.AUCH01000015_gene2502	1.29e-52	186.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,2KVW3@206389|Rhodocyclales	206389|Rhodocyclales	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_110433_1	323848.Nmul_A2333	1.3e-90	273.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,37232@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_110433_2	323848.Nmul_A2332	1.1e-11	64.7	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,372BM@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_272612_1	748247.AZKH_0484	5.26e-117	341.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2VJQG@28216|Betaproteobacteria,2KUXA@206389|Rhodocyclales	206389|Rhodocyclales	H	Bacterial extracellular solute-binding protein	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k59_272612_2	631454.N177_1930	3.52e-50	166.0	COG1126@1|root,COG1126@2|Bacteria,1MWKQ@1224|Proteobacteria,2TSCU@28211|Alphaproteobacteria,1JQ5M@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
k59_632511_1	1288494.EBAPG3_21040	1.96e-63	218.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VHNB@28216|Betaproteobacteria,371VU@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_110434_2	622637.KE124774_gene1328	2.82e-45	159.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_143126_1	977880.RALTA_A1696	9.15e-114	352.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,1K0GW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_530367_1	398511.BpOF4_09670	4.64e-26	102.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,4HAKZ@91061|Bacilli,1ZB9C@1386|Bacillus	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
k59_530367_2	360107.CHAB381_0846	1.15e-17	77.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,42V3S@68525|delta/epsilon subdivisions,2YQ9B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
k59_530367_3	1121927.GOHSU_14_00660	2.81e-07	51.6	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4GANC@85026|Gordoniaceae	201174|Actinobacteria	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_892996_1	1335230.S5VM70_9CAUD	2.97e-44	157.0	4QCDQ@10239|Viruses,4QQ6Y@28883|Caudovirales,4QIT1@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_567699_1	382245.ASA_1070	7.42e-19	90.9	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1Y3M1@135624|Aeromonadales	135624|Aeromonadales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_926911_1	768671.ThimaDRAFT_4037	3.49e-96	294.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,1SDJ1@1236|Gammaproteobacteria,1X0RY@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_371030_2	436308.Nmar_1633	1.77e-153	436.0	COG0388@1|root,arCOG00062@2157|Archaea,41SF8@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_892999_1	388051.AUFE01000007_gene1427	3.82e-42	150.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJH2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_238730_1	748247.AZKH_3249	9.21e-32	123.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,2KU79@206389|Rhodocyclales	206389|Rhodocyclales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_926925_1	1469613.JT55_08805	9.2e-18	85.1	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria,3FDV7@34008|Rhodovulum	28211|Alphaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	ddpB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_991317_2	1123487.KB892858_gene2242	3.31e-33	117.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,2VTIQ@28216|Betaproteobacteria,2KYTR@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_567729_1	987059.RBXJA2T_09934	1.07e-74	234.0	COG2301@1|root,COG2301@2|Bacteria,1Q91U@1224|Proteobacteria,2VJJY@28216|Betaproteobacteria,1KJMT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the HpcH HpaI aldolase family	citE	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_143161_2	1301098.PKB_5481	3.05e-09	57.8	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_893026_1	1366050.N234_29970	5.92e-43	152.0	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,2VHP0@28216|Betaproteobacteria,1K0GB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
k59_502577_1	880072.Desac_1208	8.08e-92	287.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MR8Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5	nuoL-2	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_175781_1	1254432.SCE1572_43755	9.06e-41	152.0	COG0265@1|root,COG1005@1|root,COG0265@2|Bacteria,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2YYND@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh,PDZ_2
k59_1018076_1	933262.AXAM01000010_gene1381	2.44e-22	98.2	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MHV4@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
k59_731029_1	177437.HRM2_21610	3e-47	155.0	COG0822@1|root,COG0822@2|Bacteria,1RK6R@1224|Proteobacteria,42SDR@68525|delta/epsilon subdivisions,2WPJJ@28221|Deltaproteobacteria,2MK9D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_530385_1	1268622.AVS7_00150	5.35e-45	157.0	COG0695@1|root,COG0695@2|Bacteria,1RC6T@1224|Proteobacteria,2VQW9@28216|Betaproteobacteria,4AH6Y@80864|Comamonadaceae	28216|Betaproteobacteria	O	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,Glutaredoxin
k59_530385_2	742159.HMPREF0004_3416	1.59e-10	62.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_78195_1	1469613.JT55_01190	1.93e-11	62.4	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2UF4X@28211|Alphaproteobacteria,3FEFI@34008|Rhodovulum	28211|Alphaproteobacteria	S	YCII-related domain	yciI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_893038_2	1123024.AUII01000006_gene4637	4.47e-28	108.0	COG0845@1|root,COG0845@2|Bacteria,2I53W@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_502592_1	999541.bgla_2g26230	5.08e-120	350.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VKN4@28216|Betaproteobacteria,1K579@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_991347_1	998088.B565_2630	2.84e-27	107.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1Y56W@135624|Aeromonadales	135624|Aeromonadales	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_707026_1	138119.DSY3546	1.55e-28	117.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
k59_935287_2	1229909.NSED_04455	2.64e-27	100.0	COG0255@1|root,arCOG00785@2157|Archaea,41SV8@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_768021_1	395494.Galf_1772	7.52e-96	285.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,44VAM@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_768021_2	391165.GbCGDNIH1_0405	4.61e-15	75.5	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
k59_739484_1	518766.Rmar_2129	2.65e-83	262.0	COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1FIWI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_346895_1	1211115.ALIQ01000174_gene3538	9.12e-106	312.0	COG0395@1|root,COG0395@2|Bacteria,1MXTE@1224|Proteobacteria,2TSM4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_346895_2	234267.Acid_4808	2.78e-13	70.5	COG0524@1|root,COG0524@2|Bacteria,3Y659@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.184	ko:K18478	-	-	R10970	RC00002,RC00017	ko00000,ko01000	-	-	-	PfkB
k59_837586_1	977880.RALTA_A1894	4.3e-26	112.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,1K3JV@119060|Burkholderiaceae	28216|Betaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_216070_1	742740.HMPREF9474_01203	5.59e-31	126.0	COG5280@1|root,COG5283@1|root,COG5412@1|root,COG5280@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,21YY2@1506553|Lachnoclostridium	186801|Clostridia	M	Phage tail tape measure protein, TP901 family	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail,TMP
k59_999358_1	764299.STRIC_2334	4.34e-52	177.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,4HBD5@91061|Bacilli	91061|Bacilli	T	phosphate starvation-inducible protein PhoH	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_739497_2	1174504.AJTN02000184_gene162	7.56e-44	153.0	COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,1ZD7C@1386|Bacillus	91061|Bacilli	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_868967_1	1121396.KB893067_gene1558	4.62e-17	80.1	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MIJV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_868967_2	933262.AXAM01000008_gene1971	2.2e-73	232.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2MI2A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528	Seryl_tRNA_N,tRNA-synt_2b
k59_576062_1	477184.KYC_09906	1.39e-46	162.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2VM8X@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_183727_1	1121920.AUAU01000002_gene2003	8.79e-45	157.0	COG0280@1|root,COG0280@2|Bacteria,3Y6AD@57723|Acidobacteria	57723|Acidobacteria	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
k59_935318_1	1229909.NSED_08115	2.05e-32	117.0	arCOG08684@1|root,arCOG08684@2157|Archaea,41T64@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_674281_1	62928.azo0508	3.29e-56	180.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2VSQF@28216|Betaproteobacteria,2KWIK@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
k59_118717_1	1446473.JHWH01000015_gene3582	1.17e-34	132.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,2PUX7@265|Paracoccus	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_346922_1	1121405.dsmv_2683	2.33e-93	288.0	28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_379981_1	485913.Krac_7606	3.3e-76	240.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G9RC@200795|Chloroflexi	200795|Chloroflexi	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_512045_1	748247.AZKH_0352	6.35e-29	112.0	COG2010@1|root,COG2010@2|Bacteria,1R48P@1224|Proteobacteria,2VPF4@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3
k59_512045_2	323259.Mhun_0966	1.69e-19	85.5	COG2703@1|root,arCOG06577@2157|Archaea,2XX8P@28890|Euryarchaeota,2NBIH@224756|Methanomicrobia	224756|Methanomicrobia	P	Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
k59_512045_3	1283300.ATXB01000001_gene1237	2.64e-11	62.4	COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,1RRYH@1236|Gammaproteobacteria,1XG9S@135618|Methylococcales	135618|Methylococcales	L	Endonuclease V	-	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
k59_348101_1	292459.STH3208	1.45e-29	121.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_577334_2	1231391.AMZF01000013_gene2628	2.71e-99	300.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,3T390@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_708318_1	1117108.PAALTS15_25039	7.06e-54	178.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,26SBQ@186822|Paenibacillaceae	91061|Bacilli	IQ	short-chain	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_1000523_1	1205680.CAKO01000030_gene4922	8.2e-34	129.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_22245_2	402626.Rpic_2120	3.75e-18	82.0	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2VRBU@28216|Betaproteobacteria,1K77V@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Haem-degrading	glcG	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Haem_degrading
k59_791335_1	378806.STAUR_1618	1.47e-37	144.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2WN0Z@28221|Deltaproteobacteria,2YYPW@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 3 C-terminal domain	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
k59_379987_1	1123487.KB892868_gene1268	9.79e-24	105.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,2KVAV@206389|Rhodocyclales	206389|Rhodocyclales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_577336_1	945713.IALB_0464	2.23e-148	430.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
k59_1022590_1	225937.HP15_3896	4.77e-18	88.6	COG3063@1|root,COG3063@2|Bacteria,1QWCK@1224|Proteobacteria,1T2TU@1236|Gammaproteobacteria,46D50@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_901822_1	713586.KB900536_gene617	9.49e-86	261.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1X1MB@135613|Chromatiales	135613|Chromatiales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_769134_1	1380358.JADJ01000007_gene3191	4.78e-52	180.0	COG0169@1|root,COG0408@1|root,COG0169@2|Bacteria,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1XIDG@135619|Oceanospirillales	135619|Oceanospirillales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_769134_2	754331.AEME01000001_gene3803	3.09e-33	123.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,3XN9Z@561|Escherichia	1236|Gammaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate	tsaC	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061710,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
k59_708328_1	297246.lpp2368	4.77e-49	160.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,1S73Y@1236|Gammaproteobacteria,1JEX7@118969|Legionellales	118969|Legionellales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_87742_1	983917.RGE_41730	1.56e-64	221.0	COG2199@1|root,COG3447@1|root,COG3614@1|root,COG5002@1|root,COG3447@2|Bacteria,COG3614@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1R7HC@1224|Proteobacteria,2WI6A@28216|Betaproteobacteria,1KJYG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	CHASE	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,MASE1,Response_reg
k59_246768_1	330214.NIDE1428	7.61e-88	268.0	COG1119@1|root,COG1119@2|Bacteria	2|Bacteria	P	ATPase activity	modF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21,3.6.3.34	ko:K02013,ko:K02028,ko:K05776	ko02010,map02010	M00189,M00236,M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.3	-	-	ABC_tran
k59_641814_1	215803.DB30_0029	1.24e-33	135.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2YUN3@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_512062_1	330214.NIDE2245	4.44e-144	416.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10,Fer4_4,Fer4_5,Fer4_9
k59_769137_1	1144343.PMI41_00008	0.000381	42.0	COG1172@1|root,COG1172@2|Bacteria,1MUDF@1224|Proteobacteria,2U4K2@28211|Alphaproteobacteria,43QWK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_769137_2	1408224.SAMCCGM7_c2367	4.34e-90	270.0	COG1129@1|root,COG1129@2|Bacteria,1MW4I@1224|Proteobacteria,2TY4S@28211|Alphaproteobacteria,4BA4T@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_313942_2	1229909.NSED_01905	1.89e-31	114.0	COG1730@1|root,arCOG01341@2157|Archaea,41SSP@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
k59_791338_1	62928.azo3894	4.83e-30	119.0	COG3515@1|root,COG3515@2|Bacteria,1NK35@1224|Proteobacteria,2VQ1C@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM type VI secretion-associated protein, ImpA family	-	-	-	ko:K11902	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	ImpA_N
k59_277333_1	1268622.AVS7_00926	2.53e-48	168.0	COG3181@1|root,COG3181@2|Bacteria,1NQXP@1224|Proteobacteria,2W14H@28216|Betaproteobacteria,4AH1H@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_901831_1	945713.IALB_0570	3.12e-74	232.0	COG0053@1|root,COG0053@2|Bacteria	2|Bacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_641820_1	743720.Psefu_3840	2.75e-54	191.0	COG2199@1|root,COG2199@2|Bacteria,1R80Z@1224|Proteobacteria,1RZUV@1236|Gammaproteobacteria,1YV6M@136845|Pseudomonas putida group	1236|Gammaproteobacteria	T	Diguanylate cyclase	yliF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	iSBO_1134.SBO_0726	GAPES2,GGDEF
k59_675554_1	1163617.SCD_n01712	5.13e-41	136.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_380005_1	580332.Slit_0533	3.6e-53	189.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_184808_1	1056495.Calag_0332	1.7e-06	55.8	COG0674@1|root,arCOG01606@2157|Archaea,2XQ12@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_87762_1	330214.NIDE0237	4.24e-59	200.0	COG1360@1|root,COG1360@2|Bacteria	2|Bacteria	N	Flagellar Motor Protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
k59_217294_1	1266925.JHVX01000008_gene372	4.14e-48	162.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,371Z8@32003|Nitrosomonadales	28216|Betaproteobacteria	D	PFAM Cobyrinic acid a,c-diamide synthase	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_217294_2	472759.Nhal_3956	1.96e-19	85.5	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1WXDT@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_577371_1	987059.RBXJA2T_09869	3.86e-108	332.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,1KK96@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Methylmalonyl-CoA mutase	icmF	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_708362_1	706587.Desti_1404	5.94e-21	99.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
k59_380023_1	1038858.AXBA01000011_gene1454	2.32e-102	313.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_675578_1	1906.SFRA_29250	9.24e-35	130.0	COG2520@1|root,COG2520@2|Bacteria,2I388@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
k59_313981_2	1459636.NTE_02685	1.3e-30	113.0	COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
k59_445449_1	1454004.AW11_00865	1.05e-19	86.3	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,1KPYA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_87796_1	1229909.NSED_09600	1.84e-16	77.8	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_87796_2	436308.Nmar_1794	9.92e-123	380.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
k59_708376_1	1321778.HMPREF1982_02364	3.24e-18	84.0	29UV3@1|root,316MX@2|Bacteria,1UH1R@1239|Firmicutes,24QZD@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
k59_577392_1	381666.H16_A1481	2.31e-79	256.0	COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,1K1MC@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34	mnmC	-	2.1.1.61	ko:K15461	-	-	R00601,R08702	RC00003,RC00053,RC00060,RC01483	ko00000,ko01000,ko03016	-	-	-	DAO,Methyltransf_30
k59_901870_1	1111479.AXAR01000004_gene2194	2.4e-48	169.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,4HAVY@91061|Bacilli,27837@186823|Alicyclobacillaceae	91061|Bacilli	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU39370	Amidohydro_1,Amidohydro_3
k59_410104_1	1054213.HMPREF9946_05063	1.99e-37	130.0	COG3791@1|root,COG3791@2|Bacteria,1RD31@1224|Proteobacteria,2U7QB@28211|Alphaproteobacteria,2JSST@204441|Rhodospirillales	204441|Rhodospirillales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_120010_1	1123257.AUFV01000013_gene2764	1.04e-100	298.0	COG2801@1|root,COG2801@2|Bacteria,1R6QN@1224|Proteobacteria,1S7GS@1236|Gammaproteobacteria,1X49T@135614|Xanthomonadales	135614|Xanthomonadales	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
k59_512111_1	1123501.KB902294_gene3527	1e-50	180.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1042 Acyl-CoA synthetase (NDP forming)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_512111_2	337075.U4L5F7	7e-05	47.0	COG1024@1|root,KOG0016@2759|Eukaryota,38F2P@33154|Opisthokonta,3NXV1@4751|Fungi,3QNP1@4890|Ascomycota	4751|Fungi	I	isomerase	ECI1	GO:0003674,GO:0003824,GO:0004165,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031974,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:1901575	5.3.3.8	ko:K13239	ko00071,ko04146,map00071,map04146	-	R04756	RC01078	ko00000,ko00001,ko01000	-	-	iMM904.YOR180C	ECH_1
k59_609568_1	384765.SIAM614_29596	1.14e-108	322.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	small subunit	hupS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_184845_2	1545915.JROG01000031_gene52	2.69e-79	236.0	COG3293@1|root,COG3293@2|Bacteria,1QWUI@1224|Proteobacteria,2TX5J@28211|Alphaproteobacteria,2KEGT@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_410111_2	395493.BegalDRAFT_3125	3.53e-82	256.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,1RPTT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iPC815.YPO3806,iSDY_1059.SDY_3605	BPD_transp_2,DUF3382
k59_87808_1	765911.Thivi_1814	7.27e-27	112.0	COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,1RMRM@1236|Gammaproteobacteria,1WZJU@135613|Chromatiales	135613|Chromatiales	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_54185_1	671143.DAMO_1611	3.19e-96	294.0	COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria	2|Bacteria	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
k59_451642_1	330214.NIDE0611	2.57e-111	330.0	COG1894@1|root,COG1894@2|Bacteria,3J0WX@40117|Nitrospirae	40117|Nitrospirae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_386082_1	926690.KE386573_gene2567	6.53e-31	120.0	COG2084@1|root,arCOG00247@2157|Archaea,2XVC8@28890|Euryarchaeota,23V0M@183963|Halobacteria	183963|Halobacteria	I	6-phosphogluconate dehydrogenase NAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
k59_159005_1	292415.Tbd_0386	8.11e-42	145.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria,1KRYI@119069|Hydrogenophilales	119069|Hydrogenophilales	I	GHMP kinases N terminal domain	-	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_845718_1	880072.Desac_2934	3.45e-57	188.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2MQCC@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_386090_1	580332.Slit_1617	9.35e-143	419.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_386090_2	631362.Thi970DRAFT_02661	5.21e-21	87.4	2BU1D@1|root,32PA2@2|Bacteria,1N4TV@1224|Proteobacteria,1SBJ8@1236|Gammaproteobacteria,1WZ1H@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_127339_1	1408418.JNJH01000075_gene221	2.39e-79	259.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2JV23@204441|Rhodospirillales	204441|Rhodospirillales	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_386974_1	706587.Desti_0802	5.2e-44	153.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2MQY0@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_320714_1	330214.NIDE3786	2.71e-129	396.0	COG0474@1|root,COG0474@2|Bacteria,3J0WH@40117|Nitrospirae	40117|Nitrospirae	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_416572_1	1458357.BG58_21650	9.81e-69	216.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,1K3K2@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_416572_2	83406.HDN1F_29570	1.78e-16	79.7	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_977040_1	436229.JOEH01000006_gene2847	9.08e-63	211.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,2NE72@228398|Streptacidiphilus	201174|Actinobacteria	E	Gamma-glutamyltranspeptidase	ggt1	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_585207_1	377629.TERTU_0906	7.05e-25	107.0	COG2885@1|root,COG2885@2|Bacteria,1P1AB@1224|Proteobacteria,1RMCQ@1236|Gammaproteobacteria,2PQ00@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	OmpA family	oprF	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_452570_1	392499.Swit_5197	1.04e-56	192.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria,2K3NU@204457|Sphingomonadales	204457|Sphingomonadales	L	Protein involved in DNA binding and transposition, DNA-mediated	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_95429_1	864051.BurJ1DRAFT_0123	2.5e-90	272.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VJFJ@28216|Betaproteobacteria,1KNAZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR family	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_481466_1	96561.Dole_2586	1.73e-77	251.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MI69@213118|Desulfobacterales	28221|Deltaproteobacteria	D	DNA segregation ATPase, FtsK SpoIIIE family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_775857_1	926569.ANT_19030	5.11e-64	202.0	COG2220@1|root,COG2220@2|Bacteria,2G6IQ@200795|Chloroflexi	200795|Chloroflexi	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_775857_2	926569.ANT_19040	9.5e-15	68.6	2EUFH@1|root,31CAS@2|Bacteria,2G9NZ@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_192059_1	1229205.BUPH_04677	5.52e-84	271.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria,1JZQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1007682_1	990285.RGCCGE502_20605	1.55e-20	95.1	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,4B93D@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_748548_1	1205680.CAKO01000037_gene1270	6.44e-81	256.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_224456_1	1286106.MPL1_10677	2.16e-15	80.9	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,460N9@72273|Thiotrichales	72273|Thiotrichales	NU	TIGRFAM type IV pilus biogenesis stability protein PilW	-	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_2,TPR_8
k59_127363_1	1410653.JHVC01000005_gene2582	9.76e-24	97.4	COG0454@1|root,COG0456@2|Bacteria,1V562@1239|Firmicutes,24G6G@186801|Clostridia,36HZD@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_127363_2	1157708.KB907450_gene5144	1.42e-32	122.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2VJ5B@28216|Betaproteobacteria,4AC0Y@80864|Comamonadaceae	28216|Betaproteobacteria	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
k59_716056_1	314285.KT71_06162	1.55e-82	270.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria,1J7EG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_616909_1	580327.Tthe_1471	5.4e-08	52.8	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,42GJV@68295|Thermoanaerobacterales	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_616909_2	330214.NIDE3071	1.46e-52	173.0	COG0336@1|root,COG0336@2|Bacteria,3J0JN@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_748563_1	1382304.JNIL01000001_gene1975	2.49e-07	50.1	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,4HIGQ@91061|Bacilli,279YN@186823|Alicyclobacillaceae	91061|Bacilli	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_748563_2	948106.AWZT01000076_gene395	1.38e-24	100.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2VQ7A@28216|Betaproteobacteria,1K2TS@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_387006_1	666681.M301_2437	1.37e-37	134.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria,2KMN0@206350|Nitrosomonadales	206350|Nitrosomonadales	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_481494_1	330214.NIDE1291	4.78e-76	247.0	COG0210@1|root,COG0210@2|Bacteria,3J0VX@40117|Nitrospirae	40117|Nitrospirae	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_846761_1	864051.BurJ1DRAFT_0770	1.63e-59	201.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2VICE@28216|Betaproteobacteria,1KN7G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
k59_95467_1	1411123.JQNH01000001_gene3807	9.22e-22	92.4	2E9F1@1|root,333NC@2|Bacteria,1MYU2@1224|Proteobacteria,2UAZF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_519772_2	290315.Clim_1541	3.3e-43	152.0	COG0462@1|root,COG0462@2|Bacteria,1FD7M@1090|Chlorobi	1090|Chlorobi	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_387010_1	1000565.METUNv1_00367	2.71e-71	227.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,2KUP3@206389|Rhodocyclales	206389|Rhodocyclales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_616918_1	1123393.KB891316_gene1296	7e-105	311.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2VIQ5@28216|Betaproteobacteria,1KRE4@119069|Hydrogenophilales	119069|Hydrogenophilales	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_1007712_1	929562.Emtol_0386	6.2e-54	175.0	COG0262@1|root,COG0262@2|Bacteria,4NPJF@976|Bacteroidetes,47Q1T@768503|Cytophagia	976|Bacteroidetes	H	Dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_160012_1	1191523.MROS_0228	3.6e-06	47.4	COG0250@1|root,COG0250@2|Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_160012_2	945713.IALB_0899	6.07e-23	89.0	COG0690@1|root,COG0690@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secE	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_716079_1	113355.CM001775_gene1664	1.19e-59	208.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1G32M@1117|Cyanobacteria	1117|Cyanobacteria	Q	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	PPC,VCBS
k59_944272_2	879212.DespoDRAFT_02754	3.04e-197	561.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42TZ6@68525|delta/epsilon subdivisions,2WQY3@28221|Deltaproteobacteria,2MN04@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_616925_1	1097668.BYI23_C012270	4.78e-18	81.6	COG2040@1|root,COG2040@2|Bacteria,1MUXU@1224|Proteobacteria,2W0DZ@28216|Betaproteobacteria,1KCSK@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Homocysteine S-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	S-methyl_trans
k59_616925_2	472759.Nhal_3005	1.05e-26	105.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_585263_1	1499684.CCNP01000018_gene1450	8.29e-09	64.3	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_9,Reg_prop,Response_reg,Y_Y_Y
k59_794227_1	180281.CPCC7001_1979	5.19e-69	224.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,22SI1@167375|Cyanobium	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_616927_1	987059.RBXJA2T_03738	2.08e-94	295.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,1KJKD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_224489_1	396588.Tgr7_2026	4.19e-84	276.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales	135613|Chromatiales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_716089_1	1415779.JOMH01000001_gene183	8.35e-32	126.0	28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_716089_2	1121937.AUHJ01000017_gene3012	4.33e-11	69.3	2EDVS@1|root,337QX@2|Bacteria,1NEZW@1224|Proteobacteria,1SCKV@1236|Gammaproteobacteria,46C7E@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_616935_1	580332.Slit_0441	1.89e-86	266.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,44V7U@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_29766_1	13689.BV96_00639	4.18e-42	146.0	COG0454@1|root,COG0454@2|Bacteria,1RDBA@1224|Proteobacteria,2UPEY@28211|Alphaproteobacteria,2KD5V@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_95495_1	1163617.SCD_n02229	1.86e-60	211.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Atp-dependent helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_29771_1	760117.JN27_07500	8.53e-35	128.0	COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria,2WBNZ@28216|Betaproteobacteria,4766P@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
k59_29771_2	742727.HMPREF9447_02664	6.31e-10	60.8	COG3534@1|root,COG3534@2|Bacteria,4NECK@976|Bacteroidetes,2FNNB@200643|Bacteroidia,4AMN0@815|Bacteroidaceae	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase domain protein	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_481533_1	1229909.NSED_06795	3.42e-32	113.0	arCOG10408@1|root,arCOG10408@2157|Archaea,41T82@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_775927_1	1229909.NSED_08705	1.18e-125	369.0	COG1012@1|root,arCOG01252@2157|Archaea,41T0F@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135,ko:K18601	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_192127_2	582744.Msip34_0462	3.94e-38	136.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,2KKDP@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_1026506_1	717231.Flexsi_0440	9.58e-60	195.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_95505_1	1123060.JONP01000032_gene1866	3.57e-91	279.0	COG2084@1|root,COG2084@2|Bacteria,1PU4S@1224|Proteobacteria,2TT0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_95505_2	443598.AUFA01000095_gene6164	4.78e-116	345.0	COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria,3K2UT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metC	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_281362_1	330214.NIDE3924	2.64e-26	101.0	COG4244@1|root,COG4244@2|Bacteria	2|Bacteria	E	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
k59_281362_2	330214.NIDE3925	1.01e-44	155.0	COG0446@1|root,COG0446@2|Bacteria,3J102@40117|Nitrospirae	40117|Nitrospirae	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_224521_1	1144305.PMI02_04752	1.14e-107	327.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2K9G5@204457|Sphingomonadales	204457|Sphingomonadales	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_61382_1	553385.JEMF01000131_gene1767	1.13e-17	82.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,1RQ7I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase, catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_61382_2	1366050.N234_36600	1.9e-31	115.0	COG2963@1|root,COG2963@2|Bacteria,1QVMA@1224|Proteobacteria,2WH1K@28216|Betaproteobacteria,1K7HS@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_253361_1	1288494.EBAPG3_18800	7.64e-38	139.0	COG0642@1|root,COG0642@2|Bacteria,1R514@1224|Proteobacteria,2VN33@28216|Betaproteobacteria,372UW@32003|Nitrosomonadales	28216|Betaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1007756_1	1323663.AROI01000003_gene2271	7.85e-81	256.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Mg2 and Co2 transporter CorB	yfjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_481545_1	452637.Oter_1454	3.83e-75	251.0	COG0841@1|root,COG0841@2|Bacteria,46SER@74201|Verrucomicrobia	74201|Verrucomicrobia	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_977138_2	1415756.JQMY01000001_gene733	4.69e-10	60.8	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2PF74@252301|Oceanicola	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_683412_1	1123376.AUIU01000011_gene1085	7.73e-102	315.0	COG1614@1|root,COG1614@2|Bacteria	2|Bacteria	C	CO-methylating acetyl-CoA synthase activity	cdhC	-	2.3.1.169	ko:K00193,ko:K14138	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R08433,R09096,R10219,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_416663_1	1300345.LF41_1761	1.48e-51	166.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,1X72V@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_649252_1	159087.Daro_2028	2.21e-09	56.2	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,2VWEY@28216|Betaproteobacteria,2KXCZ@206389|Rhodocyclales	206389|Rhodocyclales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
k59_649252_2	762376.AXYL_01557	2.75e-49	165.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,3T2V1@506|Alcaligenaceae	28216|Betaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_160065_1	28229.ND2E_0175	1.56e-30	122.0	COG2334@1|root,COG2334@2|Bacteria,1Q18Y@1224|Proteobacteria,1RR8Y@1236|Gammaproteobacteria,2Q7QH@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_355745_1	392499.Swit_4454	3.44e-120	349.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,2K1TH@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_585323_1	572477.Alvin_0464	2.47e-62	204.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1WXDA@135613|Chromatiales	135613|Chromatiales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_519845_1	1123376.AUIU01000014_gene578	7.45e-91	293.0	COG0178@1|root,COG0178@2|Bacteria,3J0C7@40117|Nitrospirae	40117|Nitrospirae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_95532_1	420324.KI911974_gene3127	6.56e-58	191.0	COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,2TVK9@28211|Alphaproteobacteria,1JXXT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_877586_1	330214.NIDE1364	1.42e-119	349.0	COG2116@1|root,COG2116@2|Bacteria	2|Bacteria	P	formate transmembrane transporter activity	nirC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K02598,ko:K06212,ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.2,1.A.16.3	-	iSF_1195.SF3386,iS_1188.S4377	Form_Nir_trans
k59_616996_1	748247.AZKH_3305	4.69e-51	167.0	COG1246@1|root,COG1246@2|Bacteria,1PZIK@1224|Proteobacteria,2W3YD@28216|Betaproteobacteria,2KZ7E@206389|Rhodocyclales	206389|Rhodocyclales	E	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
k59_481570_1	1499967.BAYZ01000135_gene85	2.19e-93	282.0	COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_850696_1	330214.NIDE0790	1.73e-52	167.0	COG0629@1|root,COG0629@2|Bacteria,3J0NB@40117|Nitrospirae	40117|Nitrospirae	L	Single-strand binding protein family	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_850696_2	243231.GSU0666	6.83e-24	94.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2WR7Z@28221|Deltaproteobacteria,43V5M@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_557204_1	1121918.ARWE01000001_gene1756	1.25e-69	225.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,43U00@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_655137_1	265072.Mfla_2755	8.71e-93	290.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,2KMCJ@206350|Nitrosomonadales	206350|Nitrosomonadales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_99983_1	745411.B3C1_04955	3.29e-47	162.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1J54Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0032775,GO:0034641,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140096,GO:0140097,GO:1901360,GO:1901564	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
k59_948738_1	1122211.JMLW01000004_gene2640	3.83e-23	101.0	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1XIJ8@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,2.5.1.19	ko:K00210,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025	R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
k59_948738_2	580332.Slit_2064	7.86e-67	214.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VIPQ@28216|Betaproteobacteria,44V48@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC2	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_197975_2	1116369.KB890024_gene949	9.21e-38	132.0	2D7A9@1|root,32TNM@2|Bacteria,1RJFR@1224|Proteobacteria,2UAED@28211|Alphaproteobacteria,43KG1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_916331_1	330214.NIDE4319	9.62e-12	65.1	COG0760@1|root,COG0760@2|Bacteria,3J16U@40117|Nitrospirae	40117|Nitrospirae	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
k59_916331_2	330214.NIDE4320	4.94e-24	101.0	COG0760@1|root,COG0760@2|Bacteria,3J0SR@40117|Nitrospirae	40117|Nitrospirae	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,SurA_N
k59_818421_1	1229909.NSED_00210	4.88e-85	264.0	COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_99990_2	656024.FsymDg_1057	1.14e-10	66.6	COG0110@1|root,COG0110@2|Bacteria,2GWDX@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
k59_67445_1	768671.ThimaDRAFT_1318	3.43e-53	176.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_916340_1	1340493.JNIF01000003_gene4724	2.13e-83	256.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve,rve_3
k59_850721_1	1265505.ATUG01000001_gene3405	1.82e-47	169.0	COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N,YbbR
k59_360990_1	215803.DB30_7669	1.84e-22	95.1	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42MZF@68525|delta/epsilon subdivisions,2WPA6@28221|Deltaproteobacteria,2YVGB@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_197987_1	400682.PAC_15710332	4.79e-29	119.0	COG1132@1|root,KOG0055@2759|Eukaryota,39YRK@33154|Opisthokonta,3BN4Z@33208|Metazoa	33208|Metazoa	Q	atp-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
k59_197987_2	504832.OCAR_7523	4.26e-125	374.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_295798_1	404589.Anae109_0438	7.68e-83	274.0	COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2YWE1@29|Myxococcales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_295798_2	395495.Lcho_3612	2.27e-112	334.0	COG1638@1|root,COG1638@2|Bacteria,1PMWE@1224|Proteobacteria,2VNJI@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_230412_1	598467.BrE312_4086	1.57e-87	264.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,1SF6X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	catJ	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_230412_2	1304275.C41B8_03206	4.41e-17	79.7	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,1RQB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_360993_1	675813.VIB_002946	2.61e-141	419.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XVS8@135623|Vibrionales	135623|Vibrionales	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_458906_1	1380394.JADL01000009_gene3293	3.35e-81	257.0	COG0477@1|root,COG2814@2|Bacteria,1MVKJ@1224|Proteobacteria,2TUK5@28211|Alphaproteobacteria,2JVMT@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
k59_655176_1	1288494.EBAPG3_27690	5.1e-53	187.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,371PH@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Soluble lytic murein transglycosylase L domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_263334_1	1335757.SPICUR_01345	2.48e-90	270.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_916371_1	292415.Tbd_2545	1.38e-86	268.0	COG2010@1|root,COG3439@1|root,COG2010@2|Bacteria,COG3439@2|Bacteria,1R6Z0@1224|Proteobacteria,2VRTH@28216|Betaproteobacteria,1KSIM@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,DUF302
k59_557252_1	247490.KSU1_D0316	6.61e-85	266.0	COG1008@1|root,COG1008@2|Bacteria,2IX79@203682|Planctomycetes	203682|Planctomycetes	C	proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_491967_1	580332.Slit_0518	8.05e-24	94.4	COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria,44VVP@713636|Nitrosomonadales	28216|Betaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_491967_2	272560.BPSL2761	1.62e-69	218.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,1K1BT@119060|Burkholderiaceae	28216|Betaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_752579_2	444862.E3SM20_9CAUD	1.98e-27	110.0	4QAQQ@10239|Viruses,4QVZX@35237|dsDNA viruses  no RNA stage,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae	10662|Myoviridae	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1997_1	1417296.U879_08045	3.72e-40	145.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2TVK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,FAD_oxidored,Lycopene_cycl,Trp_halogenase
k59_1997_2	1417296.U879_08040	4.98e-63	206.0	COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,2U4HP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k59_263341_1	1288494.EBAPG3_9660	1.88e-149	461.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,371R1@32003|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_458917_1	428126.CLOSPI_01156	3.16e-08	60.1	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,3VPN9@526524|Erysipelotrichia	526524|Erysipelotrichia	C	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_426373_1	1163617.SCD_n02131	4.46e-75	249.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_850763_1	748658.KB907314_gene236	4.39e-47	171.0	COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,1RQ9P@1236|Gammaproteobacteria,1X2BJ@135613|Chromatiales	135613|Chromatiales	M	Cellulose synthase	-	-	-	-	-	-	-	-	-	-	-	-	Cellulose_synt,Glycos_transf_2,PilZ
k59_524479_1	1121422.AUMW01000016_gene2048	7.69e-14	77.0	COG0438@1|root,COG0438@2|Bacteria,1V5W1@1239|Firmicutes,24HV6@186801|Clostridia	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
k59_687857_1	331869.BAL199_26821	1.01e-82	263.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,4BPFM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_883300_1	1535287.JP74_12410	6.86e-05	45.4	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,2TS26@28211|Alphaproteobacteria,3N7MI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
k59_655196_1	396588.Tgr7_0954	6.62e-44	154.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1WXQH@135613|Chromatiales	135613|Chromatiales	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_589803_1	394221.Mmar10_1754	4.81e-33	125.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,43W7R@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_589803_2	522306.CAP2UW1_1138	3.26e-88	269.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2VIRF@28216|Betaproteobacteria,1KQJP@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_230444_1	93220.LV28_24415	1.78e-88	279.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,1JZXX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_720368_1	1121028.ARQE01000006_gene4509	4.44e-57	191.0	2DBB8@1|root,2Z867@2|Bacteria,1R91B@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3383
k59_393669_1	493475.GARC_0808	2.59e-68	219.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,465JF@72275|Alteromonadaceae	1236|Gammaproteobacteria	EH	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_230447_1	485917.Phep_1193	8.09e-53	185.0	COG0466@1|root,COG0466@2|Bacteria,4NE1G@976|Bacteroidetes,1IQDQ@117747|Sphingobacteriia	976|Bacteroidetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_687874_1	402777.KB235906_gene275	1.44e-42	155.0	COG3385@1|root,COG3385@2|Bacteria,1G2NV@1117|Cyanobacteria,1HEUG@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1,DDE_Tnp_2
k59_491999_1	1229909.NSED_03225	7.66e-45	152.0	COG0391@1|root,arCOG04395@2157|Archaea,41SCH@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
k59_491999_2	436308.Nmar_0627	3.26e-29	114.0	arCOG08742@1|root,arCOG08742@2157|Archaea,41SS8@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_883317_1	196367.JNFG01000031_gene8767	6.11e-136	407.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,1K1NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aconitate hydratase	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
k59_948819_1	1198114.AciX9_4522	7.06e-83	257.0	COG3039@1|root,COG3039@2|Bacteria,3Y7QJ@57723|Acidobacteria,2JMPW@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM transposase IS4 family protein	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_720378_1	1266925.JHVX01000003_gene507	1.4e-34	135.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2VHGF@28216|Betaproteobacteria,3725G@32003|Nitrosomonadales	28216|Betaproteobacteria	GM	Polysaccharide biosynthesis protein	capD	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_1012978_1	1125863.JAFN01000001_gene561	5.8e-26	102.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,43AKQ@68525|delta/epsilon subdivisions,2X60P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
k59_1012978_2	1125863.JAFN01000001_gene562	1.7e-59	194.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_100075_1	420662.Mpe_A1986	3.68e-97	294.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,1KKAN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_230456_1	1234364.AMSF01000046_gene1983	1.71e-71	230.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1X37F@135614|Xanthomonadales	135614|Xanthomonadales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
k59_67535_1	395961.Cyan7425_0147	3.35e-27	114.0	COG2433@1|root,COG2433@2|Bacteria,1G2BH@1117|Cyanobacteria,3KKNG@43988|Cyanothece	1117|Cyanobacteria	S	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_981361_1	1395571.TMS3_0118250	1.24e-66	219.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RQR1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	type II secretion system protein	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_198067_1	1173028.ANKO01000008_gene2104	2.19e-88	296.0	COG0642@1|root,COG3829@1|root,COG4251@1|root,COG0642@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1GHC4@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS_2,PAS_3,PAS_9,PHY,Response_reg
k59_622481_1	396588.Tgr7_0991	1.09e-63	206.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_622481_2	1089439.KB902251_gene1590	6.39e-21	87.4	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,460R3@72273|Thiotrichales	72273|Thiotrichales	C	NADH dehydrogenase	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_1012979_1	1121035.AUCH01000003_gene1377	3.09e-21	103.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales	206389|Rhodocyclales	NT	Methyl-accepting chemotaxis protein	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_2057_1	595494.Tola_1844	1.99e-16	80.5	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1Y59U@135624|Aeromonadales	135624|Aeromonadales	P	Cation transporter/ATPase, N-terminus	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_2057_2	237368.SCABRO_03249	3.24e-05	49.7	COG0589@1|root,COG0589@2|Bacteria,2J48V@203682|Planctomycetes	203682|Planctomycetes	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_590727_1	1232437.KL662050_gene5331	2.04e-21	96.3	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1R9T9@1224|Proteobacteria,42PPQ@68525|delta/epsilon subdivisions,2WKI9@28221|Deltaproteobacteria,2MJ5A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
k59_656142_1	261292.Nit79A3_2907	6.06e-95	290.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,371PZ@32003|Nitrosomonadales	28216|Betaproteobacteria	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_35755_1	1411123.JQNH01000001_gene687	1.27e-49	168.0	COG0382@1|root,COG0382@2|Bacteria,1RFNQ@1224|Proteobacteria,2U4XF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
k59_68487_1	649638.Trad_2420	5.87e-138	407.0	COG0405@1|root,COG0405@2|Bacteria,1WI9V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_623382_1	1254432.SCE1572_33210	3.6e-58	201.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria,2Z1M7@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
k59_68491_1	76114.ebA1117	1.44e-29	117.0	COG3271@1|root,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,2VQ1F@28216|Betaproteobacteria,2KXU7@206389|Rhodocyclales	206389|Rhodocyclales	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
k59_264293_1	391600.ABRU01000040_gene1704	1.73e-17	84.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,2KFIJ@204458|Caulobacterales	204458|Caulobacterales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_264293_2	1366050.N234_10410	4.92e-34	128.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6UF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_237731_2	1217718.ALOU01000019_gene2807	7.3e-36	129.0	COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2VMSU@28216|Betaproteobacteria,1K6EE@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_76841_1	1265505.ATUG01000002_gene1621	9.5e-94	299.0	COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2MIPK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9
k59_174493_1	1187851.A33M_3144	1.53e-49	177.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria	1224|Proteobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	aceB	GO:0003674,GO:0003824,GO:0004474,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044464,GO:0046487,GO:0046912,GO:0071704	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_4499,iLF82_1304.LF82_0013,iNRG857_1313.NRG857_20010	Malate_synthase
k59_925649_1	1198232.CYCME_1178	3.94e-25	110.0	COG0004@1|root,COG3852@1|root,COG5001@1|root,COG0004@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,45ZWR@72273|Thiotrichales	72273|Thiotrichales	PT	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,EAL,GGDEF,PAS_9
k59_759977_1	1123393.KB891316_gene1941	2.33e-44	157.0	COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,1KSQ3@119069|Hydrogenophilales	119069|Hydrogenophilales	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_759977_2	1036674.A28LD_1278	7.54e-15	71.6	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,2QG07@267893|Idiomarinaceae	1236|Gammaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_109227_1	103733.JNYO01000011_gene4867	2.76e-24	110.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4DXFV@85010|Pseudonocardiales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_109229_1	864051.BurJ1DRAFT_2867	2.65e-75	250.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ1H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	nolG	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_631299_1	1121403.AUCV01000042_gene120	1.39e-82	258.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2WJ0B@28221|Deltaproteobacteria,2MJ55@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_43828_1	1229205.BUPH_00868	2.9e-34	125.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VI2N@28216|Betaproteobacteria,1K414@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_43828_2	640511.BC1002_4562	6.71e-41	149.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2VMZ5@28216|Betaproteobacteria,1K3K6@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_697290_1	1163617.SCD_n01478	1.22e-134	391.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_141900_2	1380394.JADL01000003_gene5119	2.87e-40	150.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2JPB3@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_566493_1	877455.Metbo_1449	4.74e-28	108.0	COG1741@1|root,arCOG02935@2157|Archaea,2XU8Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the Pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_566493_2	756067.MicvaDRAFT_0666	1.03e-33	125.0	COG0667@1|root,COG0667@2|Bacteria,1G1XV@1117|Cyanobacteria,1H9HM@1150|Oscillatoriales	1117|Cyanobacteria	C	PFAM Aldo keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_237762_1	269797.Mbar_A1663	7.47e-110	327.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_827819_1	1110502.TMO_1956	1.84e-16	79.7	COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,2JPTM@204441|Rhodospirillales	204441|Rhodospirillales	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_827819_2	936455.KI421499_gene4535	2.18e-89	271.0	COG1028@1|root,COG1028@2|Bacteria,1QWBB@1224|Proteobacteria,2U2FD@28211|Alphaproteobacteria,3JSE3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_17420	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_43840_2	1168034.FH5T_01550	3.17e-26	108.0	COG1520@1|root,COG1520@2|Bacteria,4P1VG@976|Bacteroidetes,2FW8D@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
k59_729727_1	62928.azo3502	1.33e-33	123.0	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,2VRF6@28216|Betaproteobacteria,2KV9Q@206389|Rhodocyclales	206389|Rhodocyclales	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
k59_729727_2	399739.Pmen_0664	1.17e-53	172.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RP5R@1236|Gammaproteobacteria,1YDRV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
k59_697306_1	580332.Slit_1195	2.24e-139	404.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Required for the activity of the bacterial periplasmic transport system of putrescine	potD	-	-	ko:K02055,ko:K11069	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
k59_760000_1	261292.Nit79A3_0353	2.48e-72	230.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,372MW@32003|Nitrosomonadales	28216|Betaproteobacteria	O	PFAM Peptidase M48	htpX_2	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_760000_2	466038.KI421440_gene1399	2.05e-26	101.0	COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,2UCDA@28211|Alphaproteobacteria,4BQY8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Pterin 4 alpha carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_760000_3	1131553.JIBI01000016_gene614	6.41e-36	132.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,372A4@32003|Nitrosomonadales	28216|Betaproteobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_1017432_1	1121937.AUHJ01000021_gene1432	5.04e-103	307.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,46BKC@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_990133_1	1340434.AXVA01000005_gene4906	1.12e-25	105.0	COG2197@1|root,COG2197@2|Bacteria,1V407@1239|Firmicutes,4HAUN@91061|Bacilli,1ZFDD@1386|Bacillus	91061|Bacilli	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_566510_1	1211579.PP4_48460	3.73e-31	124.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RN7X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_760002_1	1120956.JHZK01000002_gene1019	6.3e-52	167.0	COG1917@1|root,COG1917@2|Bacteria,1MYMN@1224|Proteobacteria,2UR93@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_760002_2	1297570.MESS4_830435	7.49e-16	77.4	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,43HRZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_760002_3	543728.Vapar_5677	0.000113	44.7	COG3181@1|root,COG3181@2|Bacteria,1MXC0@1224|Proteobacteria,2VKN6@28216|Betaproteobacteria,4A9T4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_925695_1	1288494.EBAPG3_28150	6.04e-48	162.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,3723I@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_664550_1	96561.Dole_1739	8.7e-32	122.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42QUN@68525|delta/epsilon subdivisions,2WN6Q@28221|Deltaproteobacteria,2MKR9@213118|Desulfobacterales	28221|Deltaproteobacteria	OU	TIGRFAM signal peptide peptidase SppA, 36K type	sppA2	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_664550_2	1121104.AQXH01000006_gene2257	1.24e-16	78.6	COG0505@1|root,COG0505@2|Bacteria,4NEQI@976|Bacteroidetes,1IPSN@117747|Sphingobacteriia	976|Bacteroidetes	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_401068_2	316067.Geob_1313	2.62e-28	111.0	COG3359@1|root,COG3359@2|Bacteria,1R6A2@1224|Proteobacteria,42MVN@68525|delta/epsilon subdivisions,2WK0C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
k59_11528_1	321846.PS417_03770	2.31e-18	83.2	COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,1S5YP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Peptidyl-prolyl cis-trans	fkpB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03774	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_11528_2	1159870.KB907784_gene30	1.94e-20	88.2	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,3T1T0@506|Alcaligenaceae	28216|Betaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_891891_1	330214.NIDE1084	1.33e-45	158.0	COG0577@1|root,COG0577@2|Bacteria,3J0EW@40117|Nitrospirae	40117|Nitrospirae	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_891891_2	604331.AUHY01000014_gene2538	6.48e-34	124.0	COG1136@1|root,COG1136@2|Bacteria,1WM68@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	COG1136 ABC-type antimicrobial peptide transport system ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_435164_1	1089544.KB912942_gene6510	1.72e-11	63.5	2D1C5@1|root,32TAD@2|Bacteria,2IR5T@201174|Actinobacteria,4E5IX@85010|Pseudonocardiales	201174|Actinobacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
k59_435164_2	106648.BBLJ01000010_gene896	3.48e-14	73.6	COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,1S26A@1236|Gammaproteobacteria,3NIIJ@468|Moraxellaceae	1236|Gammaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_337622_1	426355.Mrad2831_5856	1.73e-172	507.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,1JTKB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_337622_2	1318628.MARLIPOL_12570	1.73e-69	221.0	COG0346@1|root,COG0346@2|Bacteria,1MUBT@1224|Proteobacteria,1SEDB@1236|Gammaproteobacteria,46CAQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_566533_1	1499967.BAYZ01000054_gene4817	2.18e-35	128.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	appB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_566533_2	1499967.BAYZ01000054_gene4818	1.67e-59	193.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_501367_1	1437824.BN940_14476	4.52e-59	191.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,3T8SY@506|Alcaligenaceae	28216|Betaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_501367_2	1158756.AQXQ01000012_gene1848	7.8e-07	47.4	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1WZR6@135613|Chromatiales	135613|Chromatiales	S	Zinc-finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
k59_141957_1	690585.JNNU01000003_gene5734	1.96e-34	128.0	COG0500@1|root,COG2226@2|Bacteria,1PF1R@1224|Proteobacteria,2VBXX@28211|Alphaproteobacteria,4BHXZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_566544_1	335543.Sfum_3227	9.64e-51	170.0	COG4244@1|root,COG4892@1|root,COG4244@2|Bacteria,COG4892@2|Bacteria,1N3DP@1224|Proteobacteria,42U1X@68525|delta/epsilon subdivisions,2WQFI@28221|Deltaproteobacteria,2MRX2@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Cytochrome b5-like Heme/Steroid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cyt-b5
k59_990187_1	317936.Nos7107_1111	4.81e-40	145.0	COG0076@1|root,COG0076@2|Bacteria,1G35B@1117|Cyanobacteria	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase	gadB	-	4.1.1.22,4.1.1.86	ko:K01590,ko:K13745	ko00260,ko00340,ko01100,ko01110,ko01120,map00260,map00340,map01100,map01110,map01120	-	R01167,R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
k59_43903_1	436308.Nmar_0258	3.77e-116	348.0	COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota	651137|Thaumarchaeota	C	fumarate reductase flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_599011_2	1000565.METUNv1_03018	2.22e-08	57.4	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria,2KW73@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
k59_466251_1	375286.mma_2979	8.73e-52	184.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,472GD@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_206945_1	1218075.BAYA01000022_gene5181	1.5e-116	344.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,1K15K@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_174604_1	1229909.NSED_08275	4.91e-29	105.0	arCOG08674@1|root,arCOG08674@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_174604_2	1229909.NSED_08270	1.82e-39	135.0	arCOG08675@1|root,arCOG08675@2157|Archaea,41SI5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Monooxygenase subunit B protein	-	-	-	ko:K10945	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	Monooxygenase_B
k59_338604_1	1229780.BN381_430054	6.19e-75	236.0	COG1960@1|root,COG1960@2|Bacteria,2ICK3@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_272540_1	1229172.JQFA01000002_gene4394	2.5e-16	82.8	COG1195@1|root,COG1195@2|Bacteria,1G1F6@1117|Cyanobacteria,1H7AY@1150|Oscillatoriales	1117|Cyanobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k59_567548_1	305700.B447_15361	1.53e-69	226.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,2KV73@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_567548_2	365046.Rta_28090	4.27e-37	129.0	COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,4AEP5@80864|Comamonadaceae	28216|Betaproteobacteria	C	TIGRFAM Succinate dehydrogenase, hydrophobic membrane anchor	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_567548_3	76114.ebD20	9.2e-35	123.0	COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,2VSEG@28216|Betaproteobacteria,2KWKD@206389|Rhodocyclales	206389|Rhodocyclales	C	COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_238606_1	1206744.BAGL01000050_gene911	0.000234	45.8	COG1819@1|root,COG1819@2|Bacteria,2GJMF@201174|Actinobacteria,4FWZB@85025|Nocardiaceae	201174|Actinobacteria	CG	glycosyl	gtfE	GO:0003674,GO:0003824,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0016999,GO:0017000,GO:0017144,GO:0019184,GO:0030650,GO:0030651,GO:0033071,GO:0033072,GO:0034641,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.310,2.4.1.311	ko:K16440,ko:K16444	ko01055,map01055	-	-	-	ko00000,ko00001,ko01000	-	GT1	-	Glyco_tran_28_C,Glyco_transf_28,UDPGT
k59_238606_2	101510.RHA1_ro02651	3.85e-08	56.6	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4FZ1Q@85025|Nocardiaceae	201174|Actinobacteria	C	Belongs to the cytochrome P450 family	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_175606_1	1117318.PRUB_24676	9.64e-10	67.0	COG2937@1|root,COG2937@2|Bacteria,1QYER@1224|Proteobacteria,1T3PB@1236|Gammaproteobacteria,2Q1E4@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	I	Belongs to the GPAT DAPAT family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_401888_1	56780.SYN_00285	8.66e-35	130.0	COG0845@1|root,COG0845@2|Bacteria,1PZST@1224|Proteobacteria,42R2S@68525|delta/epsilon subdivisions,2WMVJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
k59_860634_1	323261.Noc_2013	6.89e-70	226.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
k59_1017994_1	1333998.M2A_2147	6.31e-31	115.0	COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,2U7NP@28211|Alphaproteobacteria,4BSH6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_1017994_2	1232437.KL662063_gene3990	6.54e-14	71.6	COG1287@1|root,COG1287@2|Bacteria,1N1IK@1224|Proteobacteria	1224|Proteobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_760845_2	234267.Acid_2283	8.96e-27	112.0	COG0526@1|root,COG0526@2|Bacteria,3Y4MM@57723|Acidobacteria	57723|Acidobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_530304_1	1536773.R70331_17335	1.49e-37	138.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,4HAVW@91061|Bacilli,26RAP@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_502383_1	429009.Adeg_1980	2.47e-32	124.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,42FC2@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
k59_502383_2	76114.ebA5121	1.84e-33	123.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,2KWGP@206389|Rhodocyclales	206389|Rhodocyclales	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_110300_1	436308.Nmar_1751	1.77e-44	153.0	COG0162@1|root,arCOG01886@2157|Archaea,41S8C@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Tyrosine--tRNA ligase	-	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
k59_110300_2	1229909.NSED_09315	2.23e-13	65.1	arCOG08679@1|root,arCOG08679@2157|Archaea	2157|Archaea	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_698413_2	67352.JODS01000020_gene3967	6.96e-10	60.1	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_78007_1	1348657.M622_08540	5.47e-112	334.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,2KVD8@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_860640_1	1121920.AUAU01000007_gene403	8.49e-102	305.0	COG1741@1|root,COG1741@2|Bacteria,3Y831@57723|Acidobacteria	57723|Acidobacteria	S	Pirin C-terminal cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Pirin,Pirin_C
k59_575854_1	420324.KI912076_gene8329	1.79e-73	230.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,1JSVE@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_935111_1	159087.Daro_3988	1.1e-36	136.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria,2KV5T@206389|Rhodocyclales	206389|Rhodocyclales	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_935111_2	864051.BurJ1DRAFT_1620	8.46e-109	323.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VK03@28216|Betaproteobacteria,1KJYT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	hoxK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_837400_1	1192034.CAP_3990	1.1e-96	291.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2YV33@29|Myxococcales	28221|Deltaproteobacteria	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_86265_1	768671.ThimaDRAFT_0078	3.74e-31	120.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WWR6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator, LysR	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_674074_1	929556.Solca_0522	1.28e-37	142.0	COG1032@1|root,COG1032@2|Bacteria,4PHMM@976|Bacteroidetes,1IWI2@117747|Sphingobacteriia	976|Bacteroidetes	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_767876_1	420324.KI911972_gene3030	9.85e-83	274.0	COG0642@1|root,COG2203@1|root,COG3850@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria,1JXBR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Response_reg,dCache_1
k59_245507_1	1207063.P24_08439	1.23e-98	308.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JREA@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
k59_52810_1	1167006.UWK_03393	1.84e-10	67.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,42R3N@68525|delta/epsilon subdivisions,2WMY8@28221|Deltaproteobacteria,2MJPQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Transmembrane exosortase (Exosortase_EpsH)	epsH	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
k59_86273_1	887898.HMPREF0551_1956	2.48e-16	84.0	28KUM@1|root,2ZABC@2|Bacteria,1R683@1224|Proteobacteria,2VPU1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2868)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2868,DUF3482
k59_674082_1	1229909.NSED_08200	2.68e-129	375.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_900470_1	420662.Mpe_A0260	1.18e-34	127.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,1KKA5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0000226,GO:0001817,GO:0001819,GO:0001906,GO:0001907,GO:0002376,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0004365,GO:0004857,GO:0004866,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006417,GO:0006464,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007010,GO:0007017,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009620,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010033,GO:0010466,GO:0010468,GO:0010506,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016241,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016769,GO:0016903,GO:0017014,GO:0017144,GO:0017148,GO:0018119,GO:0018130,GO:0018193,GO:0018198,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019730,GO:0019752,GO:0019828,GO:0019904,GO:0030162,GO:0030234,GO:0030414,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031341,GO:0031343,GO:0031640,GO:0031647,GO:0031965,GO:0031967,GO:0031975,GO:0032268,GO:0032269,GO:0032787,GO:0032879,GO:0032880,GO:0032991,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035605,GO:0035606,GO:0035821,GO:0036094,GO:0036211,GO:0042221,GO:0042802,GO:0042866,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043086,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043436,GO:0043891,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0045087,GO:0045861,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050662,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050790,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051287,GO:0051336,GO:0051346,GO:0051402,GO:0051701,GO:0051702,GO:0051704,GO:0051707,GO:0051709,GO:0051712,GO:0051716,GO:0051817,GO:0051818,GO:0051851,GO:0051852,GO:0051873,GO:0051883,GO:0052040,GO:0052042,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0061134,GO:0061135,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0061844,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070887,GO:0070997,GO:0071310,GO:0071345,GO:0071346,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097159,GO:0097452,GO:0097718,GO:0098542,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:1990904,GO:2000112,GO:2000113	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_900470_2	1007105.PT7_2050	1.88e-56	194.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,3T2V8@506|Alcaligenaceae	28216|Betaproteobacteria	G	in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_473886_1	342113.DM82_646	2.34e-105	310.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,1K20D@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the GST superfamily	gstI	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_2
k59_215898_1	323848.Nmul_A1604	3.26e-120	357.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2VH5S@28216|Betaproteobacteria,3720W@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_151207_1	420324.KI911970_gene1564	8.51e-96	300.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_473890_1	44251.PDUR_18930	4.07e-72	232.0	COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,4HCX0@91061|Bacilli,26XAZ@186822|Paenibacillaceae	91061|Bacilli	C	Nickel-dependent hydrogenase	B4168_1462	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_52819_1	1387312.BAUS01000002_gene307	2.78e-40	140.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,2KKHZ@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_52819_2	580332.Slit_2401	4.13e-19	83.2	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2VHHT@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_640455_1	395495.Lcho_1123	7.16e-14	75.9	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2VIVI@28216|Betaproteobacteria,1KJ4G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	2-hydroxy-3-oxopropionate reductase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_967753_1	1305735.JAFT01000005_gene1867	5.12e-23	103.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2PEUR@252301|Oceanicola	28211|Alphaproteobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8
k59_674099_1	1218084.BBJK01000044_gene3908	5.28e-98	296.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VKXZ@28216|Betaproteobacteria,1K1HN@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily	phnW	-	2.6.1.37	ko:K03430	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R04152	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_5
k59_118548_1	330214.NIDE2545	5.1e-117	364.0	COG0458@1|root,COG0458@2|Bacteria,3J0BC@40117|Nitrospirae	40117|Nitrospirae	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_183596_1	1218108.KB908291_gene530	1.07e-82	272.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1HX21@117743|Flavobacteriia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_20879_1	1000565.METUNv1_02549	2.51e-05	45.4	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VJCP@28216|Betaproteobacteria,2KW05@206389|Rhodocyclales	206389|Rhodocyclales	S	SNARE associated Golgi protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_20879_2	29581.BW37_00029	1.51e-70	224.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,472UD@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_837443_1	1116472.MGMO_134c00040	1.11e-102	307.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,1RPYA@1236|Gammaproteobacteria,1XDVA@135618|Methylococcales	135618|Methylococcales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_86311_1	522306.CAP2UW1_0390	1.27e-69	218.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,2VITY@28216|Betaproteobacteria,1KQS6@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	MotA/TolQ/ExbB proton channel family	exbB2	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_608130_1	1265505.ATUG01000001_gene4311	1.63e-81	264.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,43AZ4@68525|delta/epsilon subdivisions,2X6DG@28221|Deltaproteobacteria,2MPHR@213118|Desulfobacterales	1224|Proteobacteria	E	FAD dependent oxidoreductase central domain	-	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_999227_1	1089551.KE386572_gene98	2.74e-64	215.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,4BRU7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	FtsH Extracellular	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_999227_2	1120999.JONM01000025_gene3037	6.28e-14	71.6	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KPJ5@206351|Neisseriales	206351|Neisseriales	T	Sigma-54 interaction domain protein	glnG	-	-	ko:K07712,ko:K07714	ko02020,map02020	M00497,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_86314_1	1247726.MIM_c37240	2.43e-42	155.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VM8R@28216|Betaproteobacteria,3T68J@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_215941_1	82995.CR62_00675	9.4e-06	52.8	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1RSE0@1236|Gammaproteobacteria,402C2@613|Serratia	1236|Gammaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_999232_1	436308.Nmar_1259	3.14e-123	363.0	COG2132@1|root,arCOG03914@2157|Archaea,41SZT@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3
k59_408825_1	436308.Nmar_1523	0.000105	42.4	COG0347@1|root,arCOG02305@2157|Archaea,41TB5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_408825_3	436308.Nmar_1522	1.61e-08	54.7	arCOG08643@1|root,arCOG08643@2157|Archaea,41T5M@651137|Thaumarchaeota	651137|Thaumarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_967789_1	666681.M301_1638	1.74e-21	88.2	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,2KMW5@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM response regulator receiver	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_967789_2	1005048.CFU_0794	1.47e-46	152.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,474F2@75682|Oxalobacteraceae	28216|Betaproteobacteria	KT	cheY-homologous receiver domain	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_837464_1	159087.Daro_3495	2.42e-36	131.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,2KW1D@206389|Rhodocyclales	206389|Rhodocyclales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_378747_1	1266925.JHVX01000005_gene1933	3.95e-67	219.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,371UU@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_118591_1	641526.ADIWIN_0743	1.54e-20	92.0	2DNBA@1|root,32WJE@2|Bacteria,4NUM3@976|Bacteroidetes,1I4CD@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_640502_1	986075.CathTA2_1600	3.49e-74	254.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1TQAD@1239|Firmicutes,4HCMS@91061|Bacilli	91061|Bacilli	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0046983,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_936248_2	1238182.C882_3596	7.24e-38	136.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2JW7G@204441|Rhodospirillales	204441|Rhodospirillales	C	Transketolase, pyrimidine binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C
k59_313659_1	945713.IALB_2730	1.1e-53	189.0	COG0457@1|root,COG2755@1|root,COG0457@2|Bacteria,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Lipase_GDSL_2,SLH,TPR_19,TPR_8
k59_184536_2	522306.CAP2UW1_0687	2.2e-54	176.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,2VH9U@28216|Betaproteobacteria,1KPZ3@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_768848_1	76114.p2A146	1.72e-109	327.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VK6J@28216|Betaproteobacteria,2KX2N@206389|Rhodocyclales	206389|Rhodocyclales	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_968896_1	1538295.JY96_01480	2.62e-126	368.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,1KJVG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_445101_1	497321.C664_12900	9.62e-24	99.8	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,2KUVT@206389|Rhodocyclales	206389|Rhodocyclales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_445101_2	1054213.HMPREF9946_03040	9.85e-54	184.0	COG0477@1|root,COG2814@2|Bacteria,1P3S4@1224|Proteobacteria,2TVAQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_641508_1	582744.Msip34_1227	1.17e-91	282.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,2KKNK@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_21939_1	305700.B447_07137	8.14e-65	215.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales	206389|Rhodocyclales	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_277177_1	1504672.669782992	1.91e-39	133.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2VTXK@28216|Betaproteobacteria,4AEZ7@80864|Comamonadaceae	28216|Betaproteobacteria	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
k59_277177_2	76114.ebA1254	1.34e-23	99.4	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,2KV0C@206389|Rhodocyclales	206389|Rhodocyclales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_445104_1	1044.EH31_11525	1.46e-54	191.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K18E@204457|Sphingomonadales	204457|Sphingomonadales	CG	Dehydrogenase	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_791203_1	330214.NIDE3604	1.53e-150	429.0	COG0435@1|root,COG0435@2|Bacteria	2|Bacteria	O	Glutathione S-transferase	yqjG	GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.5.7,2.5.1.18	ko:K00799,ko:K07393	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	iECW_1372.ECW_m3373,iWFL_1372.ECW_m3373	GST_C_2,GST_N_2
k59_445108_1	595460.RRSWK_01652	4.32e-130	383.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K03444	-	-	-	-	ko00000,ko02000	2.A.1.1	-	-	Sugar_tr
k59_347821_1	1125973.JNLC01000013_gene3862	2.13e-37	143.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3JU3Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_675256_1	1392487.JIAD01000001_gene1715	1.31e-15	72.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,25WB4@186806|Eubacteriaceae	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_675256_2	316067.Geob_3608	8.04e-58	183.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,43U7V@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS5 family	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_968923_1	1382359.JIAL01000001_gene1484	8.96e-29	119.0	COG0210@1|root,COG0210@2|Bacteria,3Y2W8@57723|Acidobacteria,2JIDH@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_347829_1	485913.Krac_9375	4.33e-44	158.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_511776_1	265072.Mfla_0570	3.59e-150	429.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,2KKYB@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_609228_1	887898.HMPREF0551_2207	6.28e-90	274.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,1K0H9@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metXS	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_246510_1	330214.NIDE2487	2.99e-132	392.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N,MutL
k59_869914_1	330214.NIDE2457	2.73e-116	355.0	COG0542@1|root,COG0542@2|Bacteria,3J0B4@40117|Nitrospirae	40117|Nitrospirae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_184571_1	1121374.KB891578_gene3224	1.47e-21	90.9	28P60@1|root,2ZC0V@2|Bacteria,1RC8V@1224|Proteobacteria,1S29Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4194
k59_184571_2	1453501.JELR01000001_gene2569	3.83e-16	80.5	28HNB@1|root,2Z7WM@2|Bacteria,1MWQ1@1224|Proteobacteria,1RZ55@1236|Gammaproteobacteria,464IB@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_534748_1	580332.Slit_2936	4.9e-93	308.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,44W8H@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Histidine Phosphotransfer domain	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_21975_1	395494.Galf_2878	2.59e-15	75.5	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,44VF5@713636|Nitrosomonadales	28216|Betaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_2,Thioredoxin_7
k59_379747_1	1231391.AMZF01000062_gene1077	2.29e-81	256.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,3T257@506|Alcaligenaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_379753_1	391595.RLO149_c037000	4.32e-09	57.8	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_379753_2	1279038.KB907342_gene2615	8.08e-14	70.9	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,2JRCE@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_901565_1	1121035.AUCH01000003_gene1379	1.53e-35	126.0	COG2010@1|root,COG2010@2|Bacteria,1NAGW@1224|Proteobacteria,2VW71@28216|Betaproteobacteria,2KZ6Z@206389|Rhodocyclales	206389|Rhodocyclales	C	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_869930_1	203122.Sde_2288	1.04e-77	257.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RMQA@1236|Gammaproteobacteria,469AY@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_119684_1	391625.PPSIR1_06868	1.61e-31	126.0	COG0577@1|root,COG0577@2|Bacteria,1QXV8@1224|Proteobacteria,43C7Z@68525|delta/epsilon subdivisions,2X7IB@28221|Deltaproteobacteria,2YUZK@29|Myxococcales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_740500_1	316067.Geob_3403	8.69e-08	53.1	COG3005@1|root,COG3005@2|Bacteria,1N8UB@1224|Proteobacteria,43EW2@68525|delta/epsilon subdivisions,2X24R@28221|Deltaproteobacteria,43STV@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	cbcA	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_740500_2	1232410.KI421412_gene378	4.09e-113	329.0	COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,42QVP@68525|delta/epsilon subdivisions,2WMT7@28221|Deltaproteobacteria,43TYI@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Prokaryotic cytochrome b561	cbcB	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_87482_1	1220589.CD32_10650	4.37e-34	129.0	COG2159@1|root,COG2159@2|Bacteria,1UXYD@1239|Firmicutes,4HDAD@91061|Bacilli	91061|Bacilli	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	4.1.1.45,4.1.1.52	ko:K03392,ko:K22213	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_511819_1	1232410.KI421421_gene3821	2.25e-99	296.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2WJCJ@28221|Deltaproteobacteria,43T63@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Fructose-bisphosphate aldolase class-II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_1007234_2	522306.CAP2UW1_3009	1.08e-80	244.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_616432_2	1123367.C666_07095	5.83e-36	137.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,2KUWE@206389|Rhodocyclales	206389|Rhodocyclales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_519276_1	1485543.JMME01000012_gene75	3.76e-14	76.3	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,4H2GP@909932|Negativicutes	909932|Negativicutes	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_519277_1	1232437.KL661966_gene3144	1.03e-39	138.0	2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria,2MNB4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
k59_224029_1	864051.BurJ1DRAFT_3994	6.86e-149	428.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VIRC@28216|Betaproteobacteria,1KJZ9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,SGL
k59_416196_1	330214.NIDE2544	7.02e-67	213.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_416196_2	948565.AFFP02000004_gene741	1.3e-57	199.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1Y7XX@135625|Pasteurellales	135625|Pasteurellales	F	Carbamoylphosphate synthase large	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_908569_1	62928.azo3637	1.21e-80	253.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,2KVQ1@206389|Rhodocyclales	206389|Rhodocyclales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_126891_1	94122.Shewana3_0218	5.51e-05	44.3	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,2QBMD@267890|Shewanellaceae	1236|Gammaproteobacteria	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_126891_2	305700.B447_16056	1.27e-46	162.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,2KVBF@206389|Rhodocyclales	206389|Rhodocyclales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_386576_1	1380386.JIAW01000030_gene3593	2.59e-31	123.0	2C1EV@1|root,33RW1@2|Bacteria,2ICZG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_481081_1	1172181.KB911705_gene5155	1.07e-05	53.1	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_648755_1	102107.XP_008234733.1	6.17e-34	134.0	COG0069@1|root,KOG0399@2759|Eukaryota,37RTT@33090|Viridiplantae,3G7BE@35493|Streptophyta,4JK1V@91835|fabids	35493|Streptophyta	E	glutamate synthase	GLT1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009719,GO:0009725,GO:0009735,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0015930,GO:0016040,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0032502,GO:0040007,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045181,GO:0046394,GO:0046686,GO:0048589,GO:0050896,GO:0055114,GO:0060359,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901698	1.4.1.13,1.4.1.14	ko:K00264	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,GATase_2,GXGXG,Glu_syn_central,Glu_synthase,Pyr_redox_2
k59_943796_1	443143.GM18_3605	2.71e-17	87.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CheX,HATPase_c,HisKA,Response_reg
k59_616462_1	1286631.X805_12730	1.13e-54	176.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2VRCB@28216|Betaproteobacteria,1KKVD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter DctQ	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_616462_2	983917.RGE_15260	5.28e-07	48.5	COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2VU0V@28216|Betaproteobacteria,1KMF5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
k59_1007270_1	439235.Dalk_1317	5.22e-74	234.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_355210_1	1304883.KI912532_gene2260	1.36e-82	249.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales	206389|Rhodocyclales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_355210_2	290398.Csal_1908	2.02e-26	105.0	COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria,1XICU@135619|Oceanospirillales	135619|Oceanospirillales	P	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,PBP_like
k59_877091_1	436308.Nmar_1481	6.13e-84	255.0	COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota	651137|Thaumarchaeota	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_616468_1	1158292.JPOE01000002_gene2250	9.1e-79	245.0	COG0500@1|root,COG2226@2|Bacteria,1NRR4@1224|Proteobacteria,2W05F@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_616468_2	497321.C664_02750	2.8e-46	162.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,2KUMC@206389|Rhodocyclales	206389|Rhodocyclales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1007276_1	1163617.SCD_n01875	3.62e-32	124.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_60919_1	697284.ERIC2_c00070	7.16e-08	54.7	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli,26SZ3@186822|Paenibacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_60919_2	1125863.JAFN01000001_gene2287	2.1e-28	110.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	TIGRFAM type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_224065_1	1499967.BAYZ01000177_gene5756	8.51e-36	130.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	DUF4143
k59_95978_1	1206726.BAFV01000110_gene5467	2.18e-07	56.6	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria,4G672@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2
k59_944820_1	1000565.METUNv1_03322	7.51e-77	241.0	2C5U9@1|root,30FF7@2|Bacteria,1N2U0@1224|Proteobacteria,2VSBN@28216|Betaproteobacteria,2KWHS@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_481952_1	1463854.JOHT01000002_gene2067	3.36e-06	52.4	COG1063@1|root,COG1063@2|Bacteria,2GNXK@201174|Actinobacteria	201174|Actinobacteria	E	Dehydrogenase	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_321214_1	338963.Pcar_1992	6.15e-55	185.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2WKM7@28221|Deltaproteobacteria,43U4T@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	nifR3	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_749158_1	177437.HRM2_18680	6.02e-51	177.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2WJAU@28221|Deltaproteobacteria,2MJ5H@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,Response_reg
k59_585805_1	1122603.ATVI01000006_gene336	3.21e-76	250.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1X3W3@135614|Xanthomonadales	135614|Xanthomonadales	L	Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_683939_1	511995.CFPG_746	5.33e-09	62.0	COG1266@1|root,COG1266@2|Bacteria,4NHE1@976|Bacteroidetes,2FT47@200643|Bacteroidia	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_617429_1	1000565.METUNv1_03348	2.15e-24	101.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,2KU8W@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_617429_2	768671.ThimaDRAFT_4240	1.51e-20	88.2	COG1893@1|root,COG1893@2|Bacteria,1R60C@1224|Proteobacteria,1RZQZ@1236|Gammaproteobacteria,1WXZX@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_387509_1	926692.AZYG01000059_gene70	3.64e-24	100.0	COG2963@1|root,COG2963@2|Bacteria,1V6XW@1239|Firmicutes,24K7P@186801|Clostridia	186801|Clostridia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_Tnp_1
k59_387509_2	665956.HMPREF1032_03091	2.09e-26	100.0	2A5EH@1|root,30U4B@2|Bacteria,1UTI8@1239|Firmicutes,2534V@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_356213_1	671143.DAMO_1424	1.4e-90	295.0	COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria	2|Bacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_453114_1	497321.C664_10168	2.71e-83	271.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KVC4@206389|Rhodocyclales	206389|Rhodocyclales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_321219_1	697282.Mettu_3066	2.27e-82	254.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria,1XEYK@135618|Methylococcales	135618|Methylococcales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_683941_1	518766.Rmar_2390	1.55e-42	155.0	COG1523@1|root,COG4733@1|root,COG1523@2|Bacteria,COG4733@2|Bacteria,4PNDB@976|Bacteroidetes	976|Bacteroidetes	N	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,DUF4990
k59_453117_1	710696.Intca_0323	1.52e-88	273.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,4FF9T@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG3464 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_61862_1	928724.SacglDRAFT_03785	3.13e-08	58.9	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria,4DZYF@85010|Pseudonocardiales	201174|Actinobacteria	P	Molybdate ABC transporter permease	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
k59_356216_1	98439.AJLL01000068_gene1520	5.18e-79	271.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1JGRR@1189|Stigonemataceae	1117|Cyanobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GAF,GGDEF,PAS_9
k59_281667_1	665942.HMPREF1022_01318	7.56e-18	84.3	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,42Q1H@68525|delta/epsilon subdivisions,2WK7W@28221|Deltaproteobacteria,2M8T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	pfam mofrl	Glyctk	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_520358_1	586413.CCDL010000004_gene3327	1.46e-14	74.7	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,4HBKC@91061|Bacilli,23J4J@182709|Oceanobacillus	91061|Bacilli	EH	Amino-transferase class IV	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342,ko:K13950	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
k59_520358_2	748247.AZKH_p0334	3.56e-30	115.0	2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,2VSNA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2889)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2889
k59_481982_1	1288494.EBAPG3_13720	4.21e-89	270.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,371X7@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_417143_1	1000565.METUNv1_01903	4.9e-64	215.0	COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	2.7.13.3	ko:K20975	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
k59_160563_1	383372.Rcas_3551	2.16e-47	171.0	COG1132@1|root,COG1132@2|Bacteria,2G7QN@200795|Chloroflexi,374U2@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_585837_2	1127518.H9C119_9CAUD	1.11e-23	100.0	4QHD5@10239|Viruses,4QWUC@35237|dsDNA viruses  no RNA stage,4QQGJ@28883|Caudovirales,4QJT5@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_321242_1	1288494.EBAPG3_6730	3.97e-85	266.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,371M5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.2.4,1.1.3.15,1.1.5.12	ko:K00102,ko:K00104,ko:K03777	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475,R00704,R11591	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_481987_1	1168059.KB899087_gene1115	5.88e-158	469.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,3EY3J@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_683973_1	391735.Veis_4204	4.59e-13	69.7	COG3181@1|root,COG3181@2|Bacteria,1R4PJ@1224|Proteobacteria,2VNY9@28216|Betaproteobacteria,4ACK2@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_683973_2	331869.BAL199_03004	5.75e-37	127.0	COG5470@1|root,COG5470@2|Bacteria,1N012@1224|Proteobacteria,2VG1G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
k59_944877_1	1283300.ATXB01000001_gene380	1.51e-31	127.0	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XE60@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_878068_1	861299.J421_3848	1.18e-100	310.0	COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_847360_1	369723.Strop_3951	4.84e-65	216.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4DHQS@85008|Micromonosporales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, central domain	ilvB2	GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_30314_1	1123393.KB891327_gene473	8.04e-89	265.0	COG2210@1|root,COG2210@2|Bacteria,1QCK1@1224|Proteobacteria,2WE8S@28216|Betaproteobacteria,1KSAI@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_878072_1	997884.HMPREF1068_02332	1.34e-21	98.6	COG4772@1|root,COG4772@2|Bacteria,4NEJW@976|Bacteroidetes,2G3F5@200643|Bacteroidia,4AM87@815|Bacteroidaceae	976|Bacteroidetes	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_225033_1	292415.Tbd_1123	1.62e-42	142.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,1KRQ6@119069|Hydrogenophilales	119069|Hydrogenophilales	K	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_649766_1	1082933.MEA186_30901	1.16e-59	209.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_61900_1	882378.RBRH_02120	1.95e-76	244.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1K21K@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,Intron_maturas2,RVT_1
k59_417169_1	395494.Galf_0474	1.49e-62	212.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,44VNS@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
k59_649781_1	1217715.F994_01029	2.04e-19	90.1	COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,1RY89@1236|Gammaproteobacteria,3NK6C@468|Moraxellaceae	1236|Gammaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_30331_1	370438.PTH_1175	2.15e-82	259.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,26111@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_977703_1	1082933.MEA186_19907	2.44e-105	314.0	COG0683@1|root,COG0683@2|Bacteria,1MUZU@1224|Proteobacteria,2TS7Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_5,Peripla_BP_6
k59_482017_1	1229909.NSED_01430	1.32e-85	267.0	COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_453175_1	1408224.SAMCCGM7_c4409	1.08e-07	60.5	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BAVP@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16
k59_716694_1	1097668.BYI23_A015570	1.77e-24	104.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2VJ1C@28216|Betaproteobacteria,1K27J@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_356277_1	580332.Slit_1331	3.41e-113	339.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,44VI7@713636|Nitrosomonadales	28216|Betaproteobacteria	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_617512_1	671143.DAMO_0362	2.9e-73	230.0	COG2837@1|root,COG2837@2|Bacteria	2|Bacteria	P	iron assimilation	dyp	-	-	ko:K07223	-	-	-	-	ko00000	-	-	-	Dyp_perox
k59_794458_2	330214.NIDE0004	4.45e-91	290.0	COG0188@1|root,COG0188@2|Bacteria,3J0EH@40117|Nitrospirae	40117|Nitrospirae	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_387583_1	1394178.AWOO02000002_gene1786	9.66e-21	92.0	COG1545@1|root,COG1545@2|Bacteria,2GM2A@201174|Actinobacteria,4EFYI@85012|Streptosporangiales	201174|Actinobacteria	Q	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,MaoC_dehydrat_N,MaoC_dehydratas,OB_aCoA_assoc
k59_387583_2	247634.GPB2148_1795	1.3e-24	100.0	2F6IW@1|root,33Z1T@2|Bacteria,1NKX4@1224|Proteobacteria	1224|Proteobacteria	S	sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_460945_1	1198114.AciX9_2066	5.44e-60	204.0	COG1641@1|root,COG1641@2|Bacteria,3Y42R@57723|Acidobacteria,2JI6G@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
k59_167923_1	316055.RPE_1576	4.67e-37	140.0	COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,3JTX3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Retinal pigment epithelial membrane protein	MA20_08640	-	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
k59_785016_1	639282.DEFDS_0348	8.25e-20	84.7	COG0759@1|root,COG0759@2|Bacteria,2GG13@200930|Deferribacteres	200930|Deferribacteres	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
k59_785016_2	1485544.JQKP01000012_gene2118	4.88e-24	99.8	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,44UYU@713636|Nitrosomonadales	28216|Betaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_135340_1	85643.Tmz1t_1094	4.6e-75	237.0	COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,2KUYE@206389|Rhodocyclales	206389|Rhodocyclales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1014029_2	330214.NIDE3909	3.77e-98	295.0	COG0767@1|root,COG0767@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, permease component	iamB	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS,STAS_2
k59_592320_1	330214.NIDE3937	1.74e-101	327.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
k59_232519_1	436308.Nmar_1425	5.05e-25	98.6	arCOG08771@1|root,arCOG08771@2157|Archaea,41SNZ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_232519_2	436308.Nmar_1426	3.69e-53	167.0	COG3432@1|root,arCOG01055@2157|Archaea,41SUJ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
k59_754690_1	349521.HCH_05278	1.75e-83	266.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XHC9@135619|Oceanospirillales	135619|Oceanospirillales	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	pilB	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_526399_1	1288494.EBAPG3_2770	9.38e-105	325.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,3727Q@32003|Nitrosomonadales	28216|Betaproteobacteria	L	UvrD REP	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_722972_1	1095769.CAHF01000022_gene361	1.51e-71	223.0	290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,2VZ0V@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_722972_2	864073.HFRIS_014055	1.1e-39	138.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2VMEA@28216|Betaproteobacteria,478P9@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	ydaF_2	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
k59_331060_1	312153.Pnuc_0913	6.29e-88	278.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,1K2QQ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	carboxylase	pccA	-	6.4.1.3,6.4.1.4	ko:K01965,ko:K01968	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00036,M00373,M00741	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_592325_1	1206735.BAGG01000082_gene3410	4.74e-18	90.5	COG3540@1|root,COG3540@2|Bacteria,2GJCI@201174|Actinobacteria,4FWDN@85025|Nocardiaceae	201174|Actinobacteria	P	alkaline phosphatase	phoD	-	3.1.3.1	ko:K01077,ko:K01113	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	PhoD,PhoD_N
k59_395743_1	1304874.JAFY01000002_gene864	9.85e-32	119.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	thiJ	-	2.7.11.1,3.5.1.124	ko:K03152,ko:K05520,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko01002	-	-	-	DJ-1_PfpI
k59_363534_1	1437824.BN940_03881	2.43e-75	241.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VHJB@28216|Betaproteobacteria,3T2ME@506|Alcaligenaceae	28216|Betaproteobacteria	G	dehydratase	garD	-	4.2.1.42,4.2.1.7,4.4.1.24	ko:K01685,ko:K01708,ko:K16846	ko00040,ko00053,ko00270,ko01100,map00040,map00053,map00270,map01100	M00631	R01540,R05608,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_265851_1	95619.PM1_0203150	2.26e-73	238.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_265851_2	1230343.CANP01000026_gene1977	4.08e-13	65.5	COG0589@1|root,COG0589@2|Bacteria,1N02E@1224|Proteobacteria,1SEXH@1236|Gammaproteobacteria,1JF3E@118969|Legionellales	118969|Legionellales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_232525_1	391616.OA238_c47770	5.34e-67	208.0	COG3415@1|root,COG3415@2|Bacteria,1REHM@1224|Proteobacteria,2U8ST@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_232525_2	1121405.dsmv_3681	7.46e-37	134.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,42MUE@68525|delta/epsilon subdivisions,2WJFZ@28221|Deltaproteobacteria,2MK9S@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_32,rve,rve_3
k59_460952_3	5911.EAR83136	6.15e-05	48.9	COG0216@1|root,KOG2726@2759|Eukaryota	2759|Eukaryota	J	translation release factor activity	C12orf65	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0015934,GO:0016020,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0019866,GO:0022411,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032268,GO:0032543,GO:0032984,GO:0032991,GO:0034248,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0070013,GO:0070126,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0098798,GO:0140053,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112	2.1.1.43,2.4.2.12	ko:K03462,ko:K11428	ko00310,ko00760,ko01100,ko04621,map00310,map00760,map01100,map04621	-	R01271,R03875,R03938,R04866,R04867	RC00003,RC00033,RC00060,RC00181,RC00496	ko00000,ko00001,ko01000,ko03036	-	-	-	RF-1
k59_460952_4	146922.JOFU01000070_gene7797	1.36e-21	92.8	COG4696@1|root,COG4696@2|Bacteria,2IIPK@201174|Actinobacteria	201174|Actinobacteria	J	Phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,PRA-PH
k59_135360_1	1198452.Jab_1c14750	8.37e-94	285.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,475SF@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_200498_1	479434.Sthe_0987	8.63e-25	106.0	COG0247@1|root,COG0247@2|Bacteria,2G5V8@200795|Chloroflexi,27XTC@189775|Thermomicrobia	189775|Thermomicrobia	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
k59_363544_1	330214.NIDE2193	2.3e-111	333.0	COG0172@1|root,COG0172@2|Bacteria,3J0EP@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_624961_1	1265502.KB905948_gene1024	2.41e-91	280.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2VIVU@28216|Betaproteobacteria,4A9N6@80864|Comamonadaceae	28216|Betaproteobacteria	CH	4-hydroxybenzoate 3-monooxygenase	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
k59_200515_1	945713.IALB_2373	1.61e-84	262.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	waaC	-	-	ko:K02841,ko:K02843,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_460968_1	1283300.ATXB01000001_gene2236	2e-29	120.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XFDE@135618|Methylococcales	135618|Methylococcales	L	PFAM RNA-directed DNA polymerase (reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_494680_1	1454004.AW11_03381	1.85e-74	243.0	COG3386@1|root,COG3386@2|Bacteria,1QW76@1224|Proteobacteria	1224|Proteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_37388_1	1121930.AQXG01000008_gene179	1.11e-17	85.5	COG2208@1|root,COG2208@2|Bacteria,4NI98@976|Bacteroidetes,1IR5G@117747|Sphingobacteriia	976|Bacteroidetes	KT	Serine phosphatase RsbU regulator of sigma subunit	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
k59_37388_2	945713.IALB_0828	1.64e-61	190.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	btrV	-	-	ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
k59_37388_3	945713.IALB_0829	7.42e-29	107.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
k59_690510_2	1206101.AZXC01000010_gene104	2.32e-18	85.5	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_624985_1	754477.Q7C_449	9.93e-49	178.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,45ZZR@72273|Thiotrichales	72273|Thiotrichales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_9
k59_723023_1	1121434.AULY01000006_gene929	1.17e-62	215.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1014054_1	748247.AZKH_3848	9.98e-68	213.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,2KU9T@206389|Rhodocyclales	206389|Rhodocyclales	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_690514_1	379066.GAU_3827	8.82e-27	107.0	2DM5T@1|root,31U0Y@2|Bacteria,1ZUND@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
k59_135393_1	381666.H16_B1632	6.52e-61	208.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2VJZW@28216|Betaproteobacteria,1K3Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
k59_135393_2	339670.Bamb_2654	2.07e-13	73.9	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1K004@119060|Burkholderiaceae	28216|Betaproteobacteria	M	RND efflux system, outer membrane lipoprotein, NodT family	oprM	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
k59_428861_1	987059.RBXJA2T_02946	1.82e-101	315.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,1KIYN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_559882_1	1131814.JAFO01000001_gene4062	9.56e-42	150.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,3EXXT@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	SAF	MA20_06800	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
k59_559882_2	2340.JV46_13060	5.01e-28	110.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,1J5E5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_754734_1	265072.Mfla_2150	1.18e-111	336.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,2KKDR@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_200536_1	1009370.ALO_03896	9.36e-11	62.4	2CDHP@1|root,32RXU@2|Bacteria,1VQ7W@1239|Firmicutes	1239|Firmicutes	S	RsbT co-antagonist protein rsbRD N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RsbRD_N
k59_853300_1	329726.AM1_5147	3.3e-58	196.0	COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_723040_1	472759.Nhal_2872	2.06e-20	95.5	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1SYTD@1236|Gammaproteobacteria,1X2IM@135613|Chromatiales	135613|Chromatiales	EO	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M1,Peptidase_M28
k59_592394_1	977880.RALTA_A2635	2.9e-22	96.7	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,1JZZV@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_265913_1	1047013.AQSP01000076_gene1475	3.97e-90	271.0	COG0190@1|root,COG0190@2|Bacteria,2NNY1@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_559909_1	1499967.BAYZ01000174_gene5832	4.97e-39	151.0	COG3437@1|root,COG4191@1|root,COG5000@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65,4.6.1.1	ko:K01768,ko:K02488,ko:K17763	ko00230,ko02020,ko02025,ko04112,ko04113,ko04213,map00230,map02020,map02025,map04112,map04113,map04213	M00511,M00695	R00089,R00434,R08057	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022,ko03021	-	-	-	GGDEF,HAMP,HATPase_c,HisKA,HisKA_3,PAS,PAS_4,PAS_9,Response_reg
k59_461003_1	342113.DM82_1504	0.000229	43.1	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,1K17R@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	frc_13	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_461003_2	883080.HMPREF9697_01326	1.34e-40	143.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,3JRS0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.1.1.41,4.2.1.17	ko:K01692,ko:K11264	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_723053_1	335543.Sfum_2281	6.03e-70	218.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42Z4R@68525|delta/epsilon subdivisions,2WU25@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_690546_1	1502852.FG94_01835	6.35e-84	260.0	COG3344@1|root,COG3344@2|Bacteria,1R44F@1224|Proteobacteria,2VN79@28216|Betaproteobacteria,475VR@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	RVT_1
k59_526434_2	338969.Rfer_4076	1.99e-62	198.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2VPKX@28216|Betaproteobacteria,4AEXP@80864|Comamonadaceae	28216|Betaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
k59_135433_1	395494.Galf_0113	1.41e-71	234.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,44VJY@713636|Nitrosomonadales	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_135433_2	1229205.BUPH_04151	7.76e-35	121.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,1K8I2@119060|Burkholderiaceae	28216|Betaproteobacteria	G	phosphocarrier, HPr family	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_37438_1	1158294.JOMI01000001_gene1527	3.02e-51	185.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FM3B@200643|Bacteroidia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	bepE_4	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_625033_1	318996.AXAZ01000001_gene4884	2.17e-87	268.0	COG4663@1|root,COG4663@2|Bacteria,1R40U@1224|Proteobacteria,2U3KB@28211|Alphaproteobacteria,3K34G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_657937_1	1380391.JIAS01000015_gene111	9.42e-56	186.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,2U1M9@28211|Alphaproteobacteria,2JYEI@204441|Rhodospirillales	204441|Rhodospirillales	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C
k59_428908_1	518766.Rmar_2276	9.53e-55	178.0	COG0800@1|root,COG0800@2|Bacteria,4NEFY@976|Bacteroidetes	976|Bacteroidetes	G	KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
k59_754768_1	314230.DSM3645_22636	1.82e-30	119.0	COG0439@1|root,COG0439@2|Bacteria,2IWZV@203682|Planctomycetes	203682|Planctomycetes	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_754768_2	1033743.CAES01000099_gene2606	9.68e-07	50.8	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,4HH1E@91061|Bacilli,26UCZ@186822|Paenibacillaceae	91061|Bacilli	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
k59_919095_1	338969.Rfer_0412	5.73e-44	159.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,4ACXX@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	CusF_Ec,HlyD_D23
k59_4773_1	365044.Pnap_0869	1.6e-30	119.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_4773_2	4081.Solyc00g028560.1.1	3.07e-05	45.8	COG3181@1|root,2S6DS@2759|Eukaryota,37XJN@33090|Viridiplantae,3GMP2@35493|Streptophyta	35493|Streptophyta	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_136430_2	85643.Tmz1t_2529	9.6e-21	93.6	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,2KVIF@206389|Rhodocyclales	206389|Rhodocyclales	NU	COG1450 Type II secretory pathway, component PulD	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_724049_1	266265.Bxe_B0256	3.09e-24	94.4	COG2378@1|root,COG2378@2|Bacteria,1Q17A@1224|Proteobacteria,2W688@28216|Betaproteobacteria,1KDZI@119060|Burkholderiaceae	28216|Betaproteobacteria	K	regulation of single-species biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_658945_1	1265502.KB905944_gene687	1.65e-76	240.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,4AAQK@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.2,1.4.1.3	ko:K00260,ko:K00261	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_364575_1	1041146.ATZB01000084_gene7078	6.7e-96	283.0	COG3335@1|root,COG3335@2|Bacteria,1RB1C@1224|Proteobacteria,2U367@28211|Alphaproteobacteria,4BC4T@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	protein y4pE y4sA	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_332167_1	1121004.ATVC01000002_gene564	3.28e-116	349.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VIJ8@28216|Betaproteobacteria,2KQG8@206351|Neisseriales	206351|Neisseriales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_724474_2	760117.JN27_07915	1.27e-32	119.0	29717@1|root,2ZU9N@2|Bacteria,1RJ7P@1224|Proteobacteria,2VT23@28216|Betaproteobacteria,474HM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	tctB4	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_527042_1	1232410.KI421412_gene148	2.65e-38	133.0	COG1499@1|root,COG1499@2|Bacteria,1N5GB@1224|Proteobacteria,42THG@68525|delta/epsilon subdivisions,2WQ5E@28221|Deltaproteobacteria,43SN8@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	ribosomal large subunit export from nucleus	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1014687_1	43989.cce_2310	6.16e-07	48.9	COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria,1G3D1@1117|Cyanobacteria,3KHIR@43988|Cyanothece	1117|Cyanobacteria	C	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
k59_1014687_2	622637.KE124774_gene1352	3.21e-90	273.0	COG2345@1|root,COG2345@2|Bacteria,1QW55@1224|Proteobacteria,2TWMX@28211|Alphaproteobacteria,36ZUH@31993|Methylocystaceae	28211|Alphaproteobacteria	K	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
k59_952936_1	1122939.ATUD01000007_gene2131	8.8e-07	56.2	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4CTG0@84995|Rubrobacteria	84995|Rubrobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_724480_1	497964.CfE428DRAFT_2412	1.07e-72	225.0	COG0406@1|root,COG0406@2|Bacteria,46T4J@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Phosphoglycerate mutase family	phoE	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_854711_1	338969.Rfer_4060	1.91e-43	152.0	COG1409@1|root,COG1409@2|Bacteria,1MV0H@1224|Proteobacteria,2WHIF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_854711_2	580332.Slit_2262	8.02e-61	209.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,44V6H@713636|Nitrosomonadales	28216|Betaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_364975_1	1123392.AQWL01000004_gene2625	2.35e-05	44.7	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	sulfur oxidation protein SoxY	soxY	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
k59_364975_2	580332.Slit_1698	1.26e-35	124.0	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Sulphur oxidation protein SoxZ	-	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ
k59_364975_3	713586.KB900536_gene2926	2.16e-87	268.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_561357_1	926550.CLDAP_02040	1.09e-76	242.0	COG3385@1|root,COG3385@2|Bacteria,2G7UE@200795|Chloroflexi	200795|Chloroflexi	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_986225_2	1229909.NSED_09565	3.06e-98	291.0	COG4221@1|root,arCOG01265@2157|Archaea,41S66@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_660494_1	1121422.AUMW01000009_gene3354	4.42e-12	71.6	COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,24978@186801|Clostridia,260IT@186807|Peptococcaceae	186801|Clostridia	U	PFAM Sulfate transporter	sulP	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_170536_1	330214.NIDE3661	3.14e-82	250.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	CBS,GGDEF,PAS_9
k59_986227_1	252305.OB2597_05930	1.29e-47	170.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2PCFV@252301|Oceanicola	28211|Alphaproteobacteria	V	COG1132 ABC-type multidrug transport system, ATPase and permease components	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_72792_1	566466.NOR53_2087	4.34e-90	280.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RYI9@1236|Gammaproteobacteria,1J9PP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_954083_1	95619.PM1_0204815	8.85e-35	137.0	COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2202 FOG PAS PAC domain	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg
k59_756625_1	580332.Slit_2221	8.3e-144	413.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,44WCC@713636|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM ATPase associated with various cellular activities AAA_3	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_756625_2	1095769.CAHF01000023_gene511	1.21e-31	121.0	COG4313@1|root,COG4313@2|Bacteria,1R5Z9@1224|Proteobacteria,2VKTG@28216|Betaproteobacteria,477GC@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_888089_2	945713.IALB_1622	3.34e-38	130.0	COG0838@1|root,COG0838@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330,ko:K05574	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_397707_1	436308.Nmar_0403	3.93e-14	68.9	COG2019@1|root,arCOG01039@2157|Archaea,41SK7@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the archaeal adenylate kinase family	adkA	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
k59_397707_2	1229909.NSED_08810	1.02e-48	164.0	COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota	651137|Thaumarchaeota	U	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
k59_497247_1	945713.IALB_2163	1.88e-08	62.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
k59_693128_1	1499689.CCNN01000015_gene3349	3.58e-09	55.8	COG1251@1|root,COG1251@2|Bacteria,1VKDD@1239|Firmicutes,24QQH@186801|Clostridia,36MPI@31979|Clostridiaceae	186801|Clostridia	C	2Fe-2S -binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
k59_693128_2	1382306.JNIM01000001_gene539	2.08e-09	55.8	2EIKM@1|root,33CBX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_660510_1	395495.Lcho_2094	3.8e-54	195.0	COG2304@1|root,COG2911@1|root,COG2931@1|root,COG5295@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,1KK67@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TIGRFAM outer membrane adhesin like proteiin	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,Calx-beta,DUF4347,He_PIG,HemolysinCabind,VWA_2
k59_954104_1	864073.HFRIS_002958	1.06e-92	285.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,472R1@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pykA	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_268456_1	765913.ThidrDRAFT_2876	3.81e-95	292.0	COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales	135613|Chromatiales	O	smart pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
k59_660515_1	204669.Acid345_4675	7.32e-87	288.0	COG0086@1|root,COG0086@2|Bacteria,3Y2FZ@57723|Acidobacteria,2JIW0@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_855791_1	485913.Krac_9327	4.39e-84	268.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_300602_1	118168.MC7420_8133	1.46e-89	283.0	COG3387@1|root,COG3387@2|Bacteria,1G3VS@1117|Cyanobacteria,1H860@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_527623_1	436308.Nmar_1103	4.72e-90	279.0	COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota	651137|Thaumarchaeota	L	TIGRFAM excinuclease ABC, C subunit	-	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR,UvrC_HhH_N
k59_105235_1	247490.KSU1_B0100	4.34e-189	534.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_562495_1	1458427.BAWN01000044_gene2075	2.68e-78	259.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAY8@80864|Comamonadaceae	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_660527_2	1123371.ATXH01000004_gene1742	2.9e-21	91.3	COG1180@1|root,COG1180@2|Bacteria,2GH8R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_300614_1	857087.Metme_1643	7.95e-99	314.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1XEMF@135618|Methylococcales	135618|Methylococcales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_39897_1	349521.HCH_04422	9.88e-57	182.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,1S7GD@1236|Gammaproteobacteria,1XPV2@135619|Oceanospirillales	135619|Oceanospirillales	K	Nitrite reductase heme biosynthesis H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_170586_1	1384056.N787_03515	3.05e-61	199.0	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,1RP9Y@1236|Gammaproteobacteria,1X598@135614|Xanthomonadales	135614|Xanthomonadales	P	membrane protein terc	ygjT	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_366080_1	1229909.NSED_08645	6.6e-44	154.0	COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	UbiD family decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_366080_2	1131266.ARWQ01000010_gene31	1.74e-08	55.1	arCOG11448@1|root,arCOG11448@2157|Archaea,41T9T@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_562516_1	765911.Thivi_2924	4.01e-24	95.9	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S3WT@1236|Gammaproteobacteria,1WY7Z@135613|Chromatiales	135613|Chromatiales	KT	HD domain	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
k59_462875_1	1403819.BATR01000118_gene4146	6.57e-70	227.0	COG3119@1|root,COG3119@2|Bacteria,46TR4@74201|Verrucomicrobia,2IV34@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_921664_1	991905.SL003B_1173	1.97e-82	259.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,4BPD0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00410,ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
k59_170588_3	1131553.JIBI01000020_gene208	8.97e-31	120.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2VP12@28216|Betaproteobacteria,3728I@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_300621_1	330214.NIDE1336	2.98e-34	120.0	COG0099@1|root,COG0099@2|Bacteria,3J0Q5@40117|Nitrospirae	40117|Nitrospirae	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_300621_2	330214.NIDE1337	1.63e-80	239.0	COG0100@1|root,COG0100@2|Bacteria,3J0KE@40117|Nitrospirae	40117|Nitrospirae	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_300621_3	330214.NIDE1338	2.8e-118	341.0	COG0522@1|root,COG0522@2|Bacteria,3J0IC@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_137982_1	717605.Theco_3546	1.12e-77	253.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,26R9D@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_562523_1	545264.KB898749_gene63	1.57e-49	171.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales	135613|Chromatiales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_39918_1	511062.GU3_06865	6.3e-51	167.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_39918_2	1348657.M622_14315	3.18e-20	89.4	COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,2VRM0@28216|Betaproteobacteria,2KYVE@206389|Rhodocyclales	206389|Rhodocyclales	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
k59_756669_1	1121028.ARQE01000012_gene322	7.49e-35	132.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,2PJDZ@255475|Aurantimonadaceae	28211|Alphaproteobacteria	E	Glutamine synthetase, catalytic domain	glnA1	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_756669_2	488538.SAR116_1154	1.49e-11	66.6	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria,4BQ0F@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_497310_1	1125863.JAFN01000001_gene2583	7e-85	261.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	TIGRFAM acetylornithine and succinylornithine	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204	Aminotran_3
k59_203095_1	716544.wcw_0442	3.69e-92	276.0	COG1028@1|root,COG1028@2|Bacteria,2JG7F@204428|Chlamydiae	204428|Chlamydiae	IQ	KR domain	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_527647_1	102232.GLO73106DRAFT_00033450	4.08e-120	353.0	COG2089@1|root,COG2089@2|Bacteria,1G78N@1117|Cyanobacteria	1117|Cyanobacteria	M	synthase	spsE	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
k59_105278_2	1380394.JADL01000011_gene3855	1.76e-46	162.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_72859_1	1396418.BATQ01000083_gene1170	3.17e-09	57.0	COG2095@1|root,COG2095@2|Bacteria,46T9S@74201|Verrucomicrobia,2IUN7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_333701_1	983920.Y88_0976	2.1e-83	268.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,2K1DM@204457|Sphingomonadales	204457|Sphingomonadales	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
k59_986310_1	1169143.KB911037_gene4227	1.36e-14	74.3	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,2VXDK@28216|Betaproteobacteria,1K5E1@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
k59_888156_1	28444.JODQ01000009_gene3741	2.72e-09	64.3	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,2IAT1@201174|Actinobacteria,4EH1V@85012|Streptosporangiales	201174|Actinobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS
k59_954170_1	998088.B565_0776	3.6e-88	264.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1Y48V@135624|Aeromonadales	135624|Aeromonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_300651_1	1121937.AUHJ01000009_gene1566	1.33e-70	216.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,468KZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_7485_1	986075.CathTA2_1048	5.2e-18	83.6	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli	91061|Bacilli	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_7485_2	309801.trd_1193	6.84e-49	168.0	COG0434@1|root,COG0434@2|Bacteria,2G6UF@200795|Chloroflexi,27Y89@189775|Thermomicrobia	189775|Thermomicrobia	S	BtpA family	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
k59_954186_1	1122962.AULH01000007_gene1830	1.69e-07	51.6	28XPI@1|root,2ZJKC@2|Bacteria,1P52C@1224|Proteobacteria,2UVYU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_823803_1	323848.Nmul_A2344	1.05e-95	295.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,372Q8@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_39958_1	374847.Kcr_0866	2.25e-42	155.0	COG1457@1|root,arCOG03447@2157|Archaea	2157|Archaea	F	PFAM Permease for cytosine purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
k59_562564_1	338969.Rfer_0293	1.14e-37	136.0	COG3945@1|root,COG3945@2|Bacteria,1N12K@1224|Proteobacteria,2VUPY@28216|Betaproteobacteria,4AENF@80864|Comamonadaceae	28216|Betaproteobacteria	T	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_203127_1	159087.Daro_0193	9.31e-69	216.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,2VPN6@28216|Betaproteobacteria,2KV4A@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
k59_203127_2	1198452.Jab_1c05750	2.37e-14	71.6	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,47289@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_756699_1	1168065.DOK_06979	1.26e-77	245.0	COG5361@1|root,COG5361@2|Bacteria,1R4D9@1224|Proteobacteria,1S116@1236|Gammaproteobacteria,1J905@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_725720_1	552811.Dehly_1516	2.59e-76	254.0	COG2909@1|root,COG2909@2|Bacteria,2G7Q4@200795|Chloroflexi	200795|Chloroflexi	K	ATP-dependent transcriptional regulator, MalT-like, LuxR family	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_39962_1	85643.Tmz1t_3854	5.39e-105	315.0	COG0697@1|root,COG0697@2|Bacteria,1MXCD@1224|Proteobacteria,2VMQB@28216|Betaproteobacteria,2KUKE@206389|Rhodocyclales	206389|Rhodocyclales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_888187_1	1323663.AROI01000026_gene1883	2.7e-05	46.2	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,1SKD0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_888187_3	1323663.AROI01000026_gene1885	9.12e-16	71.6	2DS3D@1|root,33EC4@2|Bacteria,1P2RI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_888187_4	460265.Mnod_1231	5.84e-11	62.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,1JS2Q@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_431412_1	748247.AZKH_0916	3.66e-06	50.1	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,2KVAI@206389|Rhodocyclales	206389|Rhodocyclales	H	enzyme of heme biosynthesis	hemY	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N
k59_398617_1	1198114.AciX9_3771	1.81e-19	90.1	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria,2JMEC@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_73914_1	1038867.AXAY01000003_gene3198	4.4e-74	227.0	COG1225@1|root,COG1225@2|Bacteria,1MWJP@1224|Proteobacteria,2TSSW@28211|Alphaproteobacteria,3JTKD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Redoxin	MA20_36550	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
k59_432339_1	1232410.KI421417_gene2808	8.61e-19	85.9	COG2801@1|root,COG2801@2|Bacteria,1NUYG@1224|Proteobacteria,42ZK0@68525|delta/epsilon subdivisions,2WUUJ@28221|Deltaproteobacteria,43URT@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_757548_1	1191523.MROS_1009	9.28e-125	364.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	kch	-	-	ko:K05844,ko:K10716	-	-	-	-	ko00000,ko01000,ko02000,ko03009	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_726748_1	1454004.AW11_02738	2.53e-69	220.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,2VHF0@28216|Betaproteobacteria,1KQMR@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_463768_2	362976.HQ_2241A	2.07e-12	69.7	COG0146@1|root,arCOG01512@2157|Archaea,2Y8DU@28890|Euryarchaeota,23S12@183963|Halobacteria	183963|Halobacteria	E	N-methylhydantoinase B acetone carboxylase, alpha subunit	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_563563_2	76114.ebA4043	1.98e-102	321.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,2KVTV@206389|Rhodocyclales	206389|Rhodocyclales	C	Malic enzyme	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_694293_2	381666.H16_A1639	1.81e-93	291.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,1K2H1@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Sulfite reductase	cysI	-	1.8.1.2,1.8.7.1	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858,R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_8549_1	525903.Taci_0162	4.16e-12	75.1	COG2199@1|root,COG3437@1|root,COG5002@1|root,COG2199@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,3TBX0@508458|Synergistetes	2|Bacteria	T	Diguanylate cyclase and metal dependent phosphohydrolase	exsG	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c,HATPase_c_2,HD_5,HWE_HK,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,SpoIIE,dCache_1
k59_171589_1	478749.BRYFOR_07606	9.5e-57	194.0	COG4383@1|root,COG4383@2|Bacteria,1TS7T@1239|Firmicutes,24CCB@186801|Clostridia	186801|Clostridia	S	Mu-like prophage protein gp29	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_139038_1	272624.lpg0644	1.09e-06	56.2	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RWSC@1236|Gammaproteobacteria,1JFU4@118969|Legionellales	118969|Legionellales	Q	COG2931, RTX toxins and related Ca2 -binding proteins	rtxA-1	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_596048_1	1382306.JNIM01000001_gene1584	3.52e-08	60.1	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
k59_139040_1	518766.Rmar_0623	4.06e-14	72.4	COG0441@1|root,COG0441@2|Bacteria,4NEFT@976|Bacteroidetes,1FISK@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_139040_2	945713.IALB_1436	8.23e-38	130.0	COG0290@1|root,COG0290@2|Bacteria	2|Bacteria	J	translation initiation factor activity	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_726765_1	62928.azo1429	3.6e-79	247.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2VJ99@28216|Betaproteobacteria,2KUDU@206389|Rhodocyclales	206389|Rhodocyclales	S	Von Willebrand factor A	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_139044_1	697281.Mahau_1018	2.91e-61	207.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,42EVP@68295|Thermoanaerobacterales	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_106348_1	1123393.KB891327_gene424	9.94e-69	216.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,1KS4D@119069|Hydrogenophilales	119069|Hydrogenophilales	Q	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_726774_1	159087.Daro_0330	1.11e-50	162.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,2KWPF@206389|Rhodocyclales	206389|Rhodocyclales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_235365_1	1000565.METUNv1_02476	3.91e-54	176.0	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,2KW6F@206389|Rhodocyclales	206389|Rhodocyclales	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_824867_1	338969.Rfer_0006	3.12e-28	107.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2VQBI@28216|Betaproteobacteria,4AEP7@80864|Comamonadaceae	28216|Betaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
k59_40978_1	977880.RALTA_A1914	0.000129	45.8	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,1K14R@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the BI1 family	yccA	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
k59_1015855_1	396588.Tgr7_3044	1.48e-92	276.0	COG0515@1|root,COG0515@2|Bacteria,1NUIB@1224|Proteobacteria	1224|Proteobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_398651_1	228410.NE2290	6.25e-113	347.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,3725T@32003|Nitrosomonadales	28216|Betaproteobacteria	NU	type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GAF,T2SSE,T2SSE_N
k59_563596_1	936455.KI421499_gene7026	3.68e-63	199.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TUQB@28211|Alphaproteobacteria,3JTCF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	MA20_22610	GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_563596_2	1245469.S58_20120	1.36e-60	197.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TT64@28211|Alphaproteobacteria,3JU31@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	MA20_22605	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_498410_1	404589.Anae109_1554	8.97e-08	55.1	COG1595@1|root,COG1595@2|Bacteria,1RI7C@1224|Proteobacteria,42XJU@68525|delta/epsilon subdivisions,2WT13@28221|Deltaproteobacteria,2Z11E@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_139060_1	323848.Nmul_A1097	5.85e-97	306.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,372H6@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_726785_1	258594.RPA4700	4.73e-62	197.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria,3JS0S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	ligI	-	3.1.1.57	ko:K10221	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R04277	RC03110	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_334774_1	926550.CLDAP_31850	3.64e-159	471.0	COG0205@1|root,COG0205@2|Bacteria,2G62R@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_856903_1	543632.JOJL01000102_gene7257	9.02e-05	45.4	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4DBWJ@85008|Micromonosporales	201174|Actinobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_856903_2	338966.Ppro_1009	1.05e-32	125.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42T20@68525|delta/epsilon subdivisions,2WP7S@28221|Deltaproteobacteria,43W22@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_204121_1	1208323.B30_21117	1.26e-47	167.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_955289_1	4432.XP_010240929.1	2.35e-22	97.8	COG1806@1|root,2QQ1R@2759|Eukaryota,37NRA@33090|Viridiplantae,3GFS0@35493|Streptophyta	35493|Streptophyta	S	pyruvate, phosphate dikinase regulatory protein	-	GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.7.11.32,2.7.4.27	ko:K20115	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_955289_2	398512.JQKC01000001_gene2415	1.82e-10	58.9	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,3WPKE@541000|Ruminococcaceae	186801|Clostridia	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
k59_269552_1	1397527.Q670_11960	5.18e-46	155.0	COG3662@1|root,COG3662@2|Bacteria,1R50Q@1224|Proteobacteria,1RQJN@1236|Gammaproteobacteria,1XQSZ@135619|Oceanospirillales	135619|Oceanospirillales	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
k59_40996_1	330214.NIDE1060	1.55e-41	140.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_40996_2	330214.NIDE1061	6.28e-60	187.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	sscB	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
k59_139076_1	1380394.JADL01000009_gene3275	4.65e-09	59.3	COG0477@1|root,COG2814@2|Bacteria,1MX2P@1224|Proteobacteria,2V9TU@28211|Alphaproteobacteria,2JVBG@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_856920_1	1538295.JY96_02265	2.05e-31	121.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,2VNC8@28216|Betaproteobacteria,1KKJ8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type IV pilus biogenesis stability protein PilW	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
k59_301634_1	1265502.KB905964_gene1378	2.63e-42	144.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,4AAKJ@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_301634_2	420662.Mpe_A1125	2.17e-84	254.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,1KK0Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1015873_1	1355368.JART01000017_gene2058	1.49e-54	181.0	COG4314@1|root,COG4314@2|Bacteria,1R8N3@1224|Proteobacteria,42M7R@68525|delta/epsilon subdivisions,2YN99@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	lipoprotein involved in nitrous oxide reduction	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_301639_1	1380394.JADL01000014_gene224	3.12e-87	270.0	COG2140@1|root,COG2140@2|Bacteria,1MUZA@1224|Proteobacteria,2TTMU@28211|Alphaproteobacteria,2JV4E@204441|Rhodospirillales	204441|Rhodospirillales	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1
k59_889158_2	347256.MHO_2880	3.95e-12	65.9	COG0093@1|root,COG0093@2|Bacteria,3WTN8@544448|Tenericutes	544448|Tenericutes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_1015876_1	1202532.FF52_20490	6.61e-63	195.0	COG4898@1|root,COG4898@2|Bacteria,4NQGY@976|Bacteroidetes,1I2T4@117743|Flavobacteriia,2NWQE@237|Flavobacterium	976|Bacteroidetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_1015876_2	1463917.JODC01000008_gene3530	7.65e-05	44.3	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_41026_1	405948.SACE_7323	1.61e-17	86.7	COG0477@1|root,COG2814@2|Bacteria,2H32P@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_661676_1	237368.SCABRO_00954	2.67e-87	274.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_432422_1	444861.E3SPP1_9CAUD	2.07e-68	224.0	4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses  no RNA stage,4QPII@28883|Caudovirales	28883|Caudovirales	S	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_824922_1	1288494.EBAPG3_2870	1.48e-29	113.0	28IJP@1|root,2Z8KI@2|Bacteria,1R9DP@1224|Proteobacteria,2VVJ7@28216|Betaproteobacteria,3735I@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_824922_2	580332.Slit_2453	3.06e-50	163.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2VTZQ@28216|Betaproteobacteria,44WIP@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Polymer-forming cytoskeletal	ccmA	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_824922_3	999541.bgla_1g06090	3.1e-42	141.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,1K791@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Required for insertion of 4Fe-4S clusters	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_596107_2	1123228.AUIH01000061_gene3507	3.82e-27	100.0	COG1942@1|root,COG1942@2|Bacteria,1NBW3@1224|Proteobacteria,1SECR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_596107_3	420662.Mpe_A1659	2.68e-09	56.6	COG0702@1|root,COG0702@2|Bacteria,1N1C0@1224|Proteobacteria,2VT7I@28216|Betaproteobacteria,1KN0C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	Complex I intermediate-associated protein 30 (CIA30)	-	-	-	-	-	-	-	-	-	-	-	-	CIA30
k59_235417_1	61647.LG71_10175	2.5e-30	110.0	COG2963@1|root,COG2963@2|Bacteria,1RHBZ@1224|Proteobacteria,1S69Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	GO:0005575,GO:0005623,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009279,GO:0009405,GO:0009987,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0046483,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_235417_2	1229485.AMYV01000244_gene4472	1.27e-42	149.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1JBYH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	insF	GO:0008150,GO:0009987,GO:0032196	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_8642_1	983917.RGE_27690	9.03e-64	207.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,1KJD6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	AFG1-like ATPase	yhcM	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
k59_563653_1	472759.Nhal_1216	1.3e-58	196.0	COG0520@1|root,COG0520@2|Bacteria,1QU0N@1224|Proteobacteria,1T2JK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	aminotransferase class V	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_432436_1	1205680.CAKO01000029_gene5076	1.69e-33	127.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2U0HR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_637295_1	1144342.PMI40_01109	3.73e-81	254.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VH18@28216|Betaproteobacteria	28216|Betaproteobacteria	P	rieske 2fe-2s	alcE	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
k59_83011_1	1408473.JHXO01000010_gene3592	1.02e-56	201.0	COG2373@1|root,COG2373@2|Bacteria,4NEW9@976|Bacteroidetes,2FP6Z@200643|Bacteroidia	976|Bacteroidetes	S	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
k59_507393_1	420324.KI912037_gene2397	2.11e-72	233.0	COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,1QWKB@1224|Proteobacteria,2TX0H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE,Guanylate_cyc,Hydrolase_4
k59_507393_2	688245.CtCNB1_0411	7.53e-21	84.7	COG0346@1|root,COG0346@2|Bacteria,1RABQ@1224|Proteobacteria,2VS4J@28216|Betaproteobacteria,4AHTQ@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase bleomycin resistance	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_309788_2	335543.Sfum_0544	4.41e-49	157.0	COG1144@1|root,COG1144@2|Bacteria,1NE6F@1224|Proteobacteria,42W4G@68525|delta/epsilon subdivisions,2WS1A@28221|Deltaproteobacteria,2MS3V@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
k59_471206_1	1266998.ATUJ01000012_gene2108	1.76e-09	63.2	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,2PUG6@265|Paracoccus	28211|Alphaproteobacteria	O	Tetratricopeptide repeat	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_49796_1	94624.Bpet4737	5.97e-66	213.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,3T1ST@506|Alcaligenaceae	28216|Betaproteobacteria	H	synthetase	paaK_2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_212827_2	1265505.ATUG01000002_gene1357	8.86e-24	102.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MPSH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	hsfA	-	-	ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GAF,HTH_8,Response_reg,Sigma54_activat
k59_275047_2	1120983.KB894574_gene926	0.000753	43.5	COG1638@1|root,COG1638@2|Bacteria,1MUJY@1224|Proteobacteria,2TQNU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_115328_1	483219.LILAB_27715	5.43e-40	149.0	COG5659@1|root,COG5659@2|Bacteria,1QZTJ@1224|Proteobacteria,43924@68525|delta/epsilon subdivisions,2X47R@28221|Deltaproteobacteria,2YYFM@29|Myxococcales	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_897497_1	1157708.KB907451_gene4614	2.12e-125	363.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VK6C@28216|Betaproteobacteria,4AB0U@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1020422_1	1008459.TASI_1406	1.58e-06	51.6	COG3180@1|root,COG3180@2|Bacteria,1MUFS@1224|Proteobacteria,2VM18@28216|Betaproteobacteria,3T3AM@506|Alcaligenaceae	28216|Betaproteobacteria	S	Ammonia monooxygenase	-	-	-	ko:K07120	-	-	-	-	ko00000	-	-	-	AbrB
k59_1020422_2	1123504.JQKD01000006_gene1594	1.48e-31	124.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2VHCJ@28216|Betaproteobacteria,4ABHN@80864|Comamonadaceae	28216|Betaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_736036_1	13249.RPRC011302-PA	0.000279	42.4	COG2025@1|root,KOG3954@2759|Eukaryota,38C7G@33154|Opisthokonta,3BANP@33208|Metazoa,3CTDD@33213|Bilateria,41TPD@6656|Arthropoda,3SJFI@50557|Insecta,3E7VU@33342|Paraneoptera	33208|Metazoa	C	Electron transfer flavoprotein FAD-binding domain	ETFA	GO:0000166,GO:0001655,GO:0001700,GO:0002009,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007424,GO:0007439,GO:0007442,GO:0007443,GO:0008150,GO:0008152,GO:0008258,GO:0009055,GO:0009056,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009653,GO:0009790,GO:0009792,GO:0009888,GO:0009987,GO:0016042,GO:0016054,GO:0016310,GO:0016491,GO:0017133,GO:0017144,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0022900,GO:0030258,GO:0031974,GO:0032501,GO:0032502,GO:0032787,GO:0032991,GO:0033539,GO:0034440,GO:0034641,GO:0035239,GO:0035295,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045251,GO:0046034,GO:0046395,GO:0046483,GO:0048037,GO:0048513,GO:0048546,GO:0048565,GO:0048567,GO:0048598,GO:0048619,GO:0048729,GO:0048731,GO:0048856,GO:0050660,GO:0050662,GO:0055086,GO:0055114,GO:0055123,GO:0060429,GO:0060541,GO:0060562,GO:0061326,GO:0061333,GO:0061525,GO:0070013,GO:0071704,GO:0072001,GO:0072002,GO:0072329,GO:0072521,GO:0097159,GO:0098798,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901575,GO:1902494,GO:1990204	-	ko:K02906,ko:K03522	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	ETF,ETF_alpha
k59_736036_2	402626.Rpic_2638	1.22e-23	101.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,1K5NT@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_532714_1	1387312.BAUS01000004_gene1725	7.8e-26	110.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,2KKG8@206350|Nitrosomonadales	206350|Nitrosomonadales	C	PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_115340_1	748247.AZKH_1287	2.5e-36	142.0	COG0653@1|root,COG0653@2|Bacteria,1QZ1G@1224|Proteobacteria,2VQGH@28216|Betaproteobacteria,2KWYF@206389|Rhodocyclales	1224|Proteobacteria	U	Putative outer membrane beta-barrel porin, MtrB/PioB	-	-	-	-	-	-	-	-	-	-	-	-	MtrB_PioB
k59_343645_1	626418.bglu_2g07140	7.22e-33	131.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2VH1R@28216|Betaproteobacteria,1K2BQ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	menC	-	4.2.1.113,5.5.1.1	ko:K01856,ko:K02549	ko00130,ko00361,ko00362,ko00364,ko00623,ko01100,ko01110,ko01120,ko01220,map00130,map00361,map00362,map00364,map00623,map01100,map01110,map01120,map01220	M00116,M00568	R04031,R05300,R05390,R06989,R08116,R09229	RC00903,RC01038,RC01053,RC01108,RC01321,RC01356	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_343645_2	1380394.JADL01000016_gene413	4.48e-38	134.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TRX5@28211|Alphaproteobacteria,2JWI3@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_309819_2	713586.KB900536_gene2518	2.71e-10	60.5	COG0517@1|root,COG0517@2|Bacteria,1RJTX@1224|Proteobacteria,1S6K2@1236|Gammaproteobacteria,1X0Y1@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_670824_1	1123367.C666_10345	2.33e-87	281.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KVC4@206389|Rhodocyclales	206389|Rhodocyclales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_736055_1	1504672.669786473	1.45e-66	213.0	COG3597@1|root,COG3597@2|Bacteria,1QG9J@1224|Proteobacteria,2VIRR@28216|Betaproteobacteria,4AATU@80864|Comamonadaceae	28216|Betaproteobacteria	P	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	DUF533,TerB
k59_964514_1	1038866.KB902824_gene1292	4.28e-74	231.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2TTDW@28211|Alphaproteobacteria,3JT60@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_507441_2	452637.Oter_2162	2.94e-42	149.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_572703_2	228410.NE1876	2.36e-83	253.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,372SB@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_996106_1	637905.SVI_2278	2.31e-39	150.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2QDC5@267890|Shewanellaceae	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_964522_1	987059.RBXJA2T_00155	1.89e-72	227.0	COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2VJI6@28216|Betaproteobacteria,1KJNV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
k59_931917_1	257310.BB1175	8.79e-15	81.3	COG0715@1|root,COG0715@2|Bacteria,1RCUI@1224|Proteobacteria,2VSSG@28216|Betaproteobacteria,3T8G0@506|Alcaligenaceae	28216|Betaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_604961_1	395494.Galf_2323	3.74e-28	111.0	COG2165@1|root,COG2165@2|Bacteria,1REMT@1224|Proteobacteria,2VR8U@28216|Betaproteobacteria,44W0Y@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
k59_242831_1	1288494.EBAPG3_2720	6.76e-44	162.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,372B8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_765127_2	713586.KB900536_gene1715	9.09e-32	115.0	COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1S5GE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the bacterial histone-like protein family	VL23_14575	-	-	-	-	-	-	-	-	-	-	-	Bac_DNA_binding
k59_83069_1	9823.ENSSSCP00000019135	1.13e-16	82.4	COG1005@1|root,KOG4770@2759|Eukaryota,39SC3@33154|Opisthokonta,3BGSE@33208|Metazoa,3D3H4@33213|Bilateria,48BEV@7711|Chordata,499PZ@7742|Vertebrata,3JDU5@40674|Mammalia,4J8T3@91561|Cetartiodactyla	33208|Metazoa	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	ND1	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010033,GO:0010257,GO:0014070,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030425,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032981,GO:0032991,GO:0033108,GO:0033194,GO:0034622,GO:0034641,GO:0036477,GO:0042221,GO:0042493,GO:0042773,GO:0042775,GO:0042995,GO:0043005,GO:0043025,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044463,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0050896,GO:0055086,GO:0055114,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0097447,GO:0097458,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0120025,GO:0120038,GO:1901135,GO:1901360,GO:1901564,GO:1901700,GO:1902494,GO:1990204	1.6.5.3	ko:K03878	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADHdh
k59_637354_2	1266925.JHVX01000006_gene2084	3e-27	110.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,371SD@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_572723_1	671143.DAMO_2769	4.27e-63	214.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_637361_2	111781.Lepto7376_4006	5.01e-30	111.0	COG2940@1|root,COG2940@2|Bacteria,1GFHJ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
k59_897541_1	388413.ALPR1_02205	3.09e-89	311.0	COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47U6P@768503|Cytophagia	976|Bacteroidetes	T	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SnoaL_3
k59_507463_1	1206737.BAGF01000144_gene5739	4.48e-25	100.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4G72A@85025|Nocardiaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,FtsX
k59_507463_2	1121382.JQKG01000080_gene894	9.14e-46	167.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_309849_2	333138.LQ50_05720	1.21e-06	53.5	COG1309@1|root,COG1309@2|Bacteria,1V7H6@1239|Firmicutes,4HGE0@91061|Bacilli,1ZGFW@1386|Bacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_834206_1	227377.CBU_0274	6.6e-78	257.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1JDD5@118969|Legionellales	118969|Legionellales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_406134_1	582744.Msip34_0651	1.87e-171	493.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,2KKQ1@206350|Nitrosomonadales	206350|Nitrosomonadales	J	TIGRFAM glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_703700_1	640081.Dsui_2996	3.93e-44	159.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_604987_1	1033802.SSPSH_001317	4.25e-21	87.0	COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,1SEQ6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CbiX	cbiX	-	4.99.1.4	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R02864	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX
k59_1020449_2	1219035.NT2_27_00020	1.66e-12	76.3	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2K503@204457|Sphingomonadales	204457|Sphingomonadales	L	PFAM Transposase IS116 IS110 IS902 family, Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_115389_1	1265502.KB905934_gene3185	4.63e-64	211.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,4AC0A@80864|Comamonadaceae	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_115389_2	887062.HGR_05741	9.38e-16	76.3	COG0128@1|root,COG0283@1|root,COG0128@2|Bacteria,COG0283@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,4AC71@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
k59_441055_1	215803.DB30_5331	1.69e-18	87.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJU@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_441055_2	224325.AF_0029	4.95e-13	65.1	COG1504@1|root,arCOG04337@2157|Archaea,2Y6F4@28890|Euryarchaeota,247CC@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
k59_637376_1	1245469.S58_63370	5.05e-37	130.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,3JQQF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	gltL	-	3.6.3.21	ko:K02028,ko:K02029,ko:K09972,ko:K10004	ko02010,ko02020,map02010,map02020	M00230,M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.19,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
k59_572739_1	640081.Dsui_3392	2.38e-95	289.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria,2KVTN@206389|Rhodocyclales	206389|Rhodocyclales	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	ybdK	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
k59_375781_1	1288494.EBAPG3_27980	1.74e-77	236.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,372DD@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	algH	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_670872_1	330214.NIDE3916	1.22e-93	302.0	COG0841@1|root,COG0841@2|Bacteria,3J0VZ@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_670873_1	706587.Desti_2750	0.000771	41.2	COG4191@1|root,COG4191@2|Bacteria,1N4YV@1224|Proteobacteria,42UJD@68525|delta/epsilon subdivisions,2WR5P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_670873_2	177437.HRM2_16540	1.3e-28	112.0	COG0613@1|root,COG0613@2|Bacteria,1N68X@1224|Proteobacteria,42TYN@68525|delta/epsilon subdivisions,2WR34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PHP-associated	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP_C
k59_212914_1	1179773.BN6_16920	3.65e-39	149.0	COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,4DY0W@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
k59_115406_1	1121035.AUCH01000003_gene1324	3.79e-76	233.0	COG1802@1|root,COG1802@2|Bacteria,1MWG2@1224|Proteobacteria,2VN1E@28216|Betaproteobacteria,2KUEP@206389|Rhodocyclales	206389|Rhodocyclales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_212915_1	582899.Hden_0687	6.97e-53	176.0	COG0518@1|root,COG0518@2|Bacteria,1MYXC@1224|Proteobacteria,2UBE9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	GMP synthase (glutamine-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_471289_1	1232410.KI421413_gene936	1.67e-86	280.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,43S33@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	SecA preprotein cross-linking domain	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_309873_1	596151.DesfrDRAFT_2390	5.14e-24	100.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42M4P@68525|delta/epsilon subdivisions,2WIKX@28221|Deltaproteobacteria,2M9KK@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Polysaccharide biosynthesis protein	wbjB	-	4.2.1.115,5.1.3.2	ko:K15894,ko:K17716	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00362	R00291,R09697	RC00289,RC02609	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding_3,Polysacc_syn_2C,Polysacc_synt_2
k59_309873_2	97139.C824_05335	2.15e-45	157.0	COG0381@1|root,COG0381@2|Bacteria,1TQZT@1239|Firmicutes,247N7@186801|Clostridia,36EW4@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
k59_670880_3	7213.XP_004527601.1	2.84e-106	320.0	COG0114@1|root,KOG1317@2759|Eukaryota,38GHX@33154|Opisthokonta,3BB3C@33208|Metazoa,3CUSS@33213|Bilateria,41XPX@6656|Arthropoda,3SITG@50557|Insecta,452J7@7147|Diptera	33208|Metazoa	C	Fumarate hydratase activity. It is involved in the biological process described with	-	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_343711_1	1205680.CAKO01000038_gene2034	3e-51	172.0	COG0346@1|root,COG0346@2|Bacteria,1MX75@1224|Proteobacteria,2TRQS@28211|Alphaproteobacteria,2JVNN@204441|Rhodospirillales	204441|Rhodospirillales	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_343711_2	1123504.JQKD01000024_gene279	5.41e-44	155.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,4A9X8@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_965716_2	1229909.NSED_06770	2.04e-47	154.0	arCOG08691@1|root,arCOG08691@2157|Archaea,41T93@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_704854_1	710421.Mycch_1474	4.24e-19	88.6	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,237WJ@1762|Mycobacteriaceae	201174|Actinobacteria	S	Mo-co oxidoreductase dimerisation domain	-	-	1.8.3.1	ko:K00387	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_704854_2	1499967.BAYZ01000130_gene2591	2.57e-53	182.0	COG1760@1|root,COG1760@2|Bacteria,2NQRY@2323|unclassified Bacteria	2|Bacteria	E	Serine dehydratase alpha chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
k59_221576_1	1458427.BAWN01000006_gene393	3.16e-46	157.0	COG1024@1|root,COG1024@2|Bacteria,1MVA6@1224|Proteobacteria,2VK0W@28216|Betaproteobacteria,4AC72@80864|Comamonadaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_973892_1	205922.Pfl01_5217	7.79e-18	87.0	COG1409@1|root,COG1409@2|Bacteria,1NA5Y@1224|Proteobacteria,1RU7X@1236|Gammaproteobacteria,1YQ33@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1024949_1	172088.AUGA01000038_gene3757	4.44e-31	124.0	COG2203@1|root,COG3899@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JTYC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Pkinase
k59_1024949_2	1150626.PHAMO_230015	3.43e-09	57.4	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,2JSMN@204441|Rhodospirillales	204441|Rhodospirillales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_189085_3	439375.Oant_1512	2.99e-20	82.8	2BZTS@1|root,33131@2|Bacteria,1NBBP@1224|Proteobacteria,2UIZA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_157054_2	316058.RPB_3076	3.71e-29	113.0	COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,2TQRG@28211|Alphaproteobacteria,3JUH4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_773266_1	331869.BAL199_06134	3.36e-44	158.0	COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,2U3QT@28211|Alphaproteobacteria,4BT8C@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,COesterase,Peptidase_S9
k59_384188_1	1121405.dsmv_3737	2.09e-121	355.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,42N5K@68525|delta/epsilon subdivisions,2WK1G@28221|Deltaproteobacteria,2MHYP@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_745423_1	644282.Deba_2967	1.51e-68	218.0	COG0517@1|root,COG0745@1|root,COG0517@2|Bacteria,COG0745@2|Bacteria,1NMVW@1224|Proteobacteria,42N24@68525|delta/epsilon subdivisions,2WIQ6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Response_reg
k59_537217_1	2340.JV46_03410	1.77e-72	245.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1J4HR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	ko:K04770	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_613943_1	706587.Desti_3213	7.9e-22	99.4	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2MR19@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_582095_1	935261.JAGL01000011_gene1960	9.08e-86	259.0	COG1175@1|root,COG1175@2|Bacteria,1MVAZ@1224|Proteobacteria,2TRWF@28211|Alphaproteobacteria,43GTT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	permease	MA20_44785	-	-	ko:K17322	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	BPD_transp_1
k59_1004880_1	391595.RLO149_c008590	3.57e-42	145.0	COG3090@1|root,COG3090@2|Bacteria,1QXYB@1224|Proteobacteria,2TTWD@28211|Alphaproteobacteria,2P3YM@2433|Roseobacter	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_92387_1	1125973.JNLC01000010_gene1411	3.27e-115	341.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2TVHP@28211|Alphaproteobacteria,3JQQG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	hydrolases or acyltransferases, alpha beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF1100,Peptidase_S9
k59_92387_2	977880.RALTA_B0210	1.05e-23	99.4	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6UF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_189103_1	983545.Glaag_2259	1.06e-48	172.0	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,464WZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Na H antiporter	nhaC	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_189103_2	1125863.JAFN01000001_gene1042	1.24e-11	65.1	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_250729_1	1384484.AEQU_1866	0.00073	43.9	COG2949@1|root,COG2949@2|Bacteria,2GWVK@201174|Actinobacteria,4CVU6@84998|Coriobacteriia	84998|Coriobacteriia	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
k59_250729_2	1380354.JIAN01000008_gene3511	9.12e-18	83.2	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria,4F0W7@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_352642_2	866536.Belba_2977	4.22e-40	147.0	COG0517@1|root,COG0517@2|Bacteria,4NHKP@976|Bacteroidetes,47RBW@768503|Cytophagia	976|Bacteroidetes	S	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_646299_1	1163617.SCD_n00013	4.05e-65	219.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8
k59_582108_2	671143.DAMO_3062	9.87e-20	86.7	COG1213@1|root,COG1213@2|Bacteria,2NQ1B@2323|unclassified Bacteria	2|Bacteria	M	MobA-like NTP transferase domain	aepX	-	2.7.7.74,2.7.8.34,5.4.2.9	ko:K01841,ko:K07281,ko:K07291	ko00440,ko00562,ko01100,ko01120,ko01130,map00440,map00562,map01100,map01120,map01130	-	R00661,R09669,R09670	RC00002,RC00078,RC02792	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,NTP_transf_3,NTP_transferase,PEP_mutase
k59_1024964_1	1415779.JOMH01000001_gene2583	1.06e-138	408.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1X4TP@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the IlvD Edd family	-	-	-	-	-	-	-	-	-	-	-	-	ILVD_EDD
k59_1004896_1	713586.KB900536_gene1929	2.03e-23	105.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria	2|Bacteria	K	phosphorelay signal transduction system	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	BTAD,GGDEF,TPR_12,TPR_8,Trans_reg_C
k59_318023_1	1192124.LIG30_3307	2.47e-66	218.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2VPCI@28216|Betaproteobacteria,1K11U@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_29,HTH_32,rve
k59_613970_3	62928.azo3973	1.64e-14	71.6	COG3179@1|root,COG3409@1|root,COG3179@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	exeA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	-	ko:K02450,ko:K03791,ko:K17733	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko01011,ko02044	9.B.42	GH19	-	AAA_22,Glyco_hydro_19,PG_binding_1
k59_745452_1	1232683.ADIMK_0867	2e-61	213.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_680271_1	1191523.MROS_2581	4.77e-57	189.0	COG0142@1|root,COG0142@2|Bacteria	2|Bacteria	H	isoprenoid biosynthetic process	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_680271_2	945713.IALB_1731	4.51e-08	50.4	COG1925@1|root,COG1925@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_414069_1	1458357.BG58_18695	6.87e-20	89.7	COG2207@1|root,COG2207@2|Bacteria,1MY46@1224|Proteobacteria,2W1XW@28216|Betaproteobacteria,1KFVM@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
k59_414069_2	1502852.FG94_00042	1.39e-33	124.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria,474EJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_906197_1	1265756.AWZW01000001_gene211	5.28e-30	120.0	COG2992@1|root,COG2992@2|Bacteria,1RD3U@1224|Proteobacteria,2U71B@28211|Alphaproteobacteria,4BQPU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	bax	-	-	ko:K03796	-	-	-	-	ko00000	-	GH73	-	Glucosaminidase
k59_478980_1	351627.Csac_0055	1.37e-103	311.0	COG2801@1|root,COG2801@2|Bacteria,1V8EJ@1239|Firmicutes,24MA4@186801|Clostridia	186801|Clostridia	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_8,rve
k59_773299_1	981223.AIED01000018_gene580	1.26e-06	49.7	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,3NJ8A@468|Moraxellaceae	1236|Gammaproteobacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_157086_1	1335757.SPICUR_02345	6.42e-21	87.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1WYF7@135613|Chromatiales	135613|Chromatiales	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_157086_2	443144.GM21_0018	5.19e-29	105.0	COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,42VGM@68525|delta/epsilon subdivisions,2WSQ6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Excinuclease ABC, C subunit domain protein	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
k59_582125_1	1266925.JHVX01000003_gene431	3.32e-81	246.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2VQ83@28216|Betaproteobacteria,371PF@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Scaffold protein Nfu/NifU N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
k59_713035_1	929562.Emtol_1229	1.21e-67	222.0	COG2272@1|root,COG2272@2|Bacteria,4NG5B@976|Bacteroidetes,47JGD@768503|Cytophagia	976|Bacteroidetes	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
k59_157087_1	631454.N177_2343	5.34e-51	172.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,2TVRD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
k59_58462_1	977880.RALTA_A1397	1.84e-95	290.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_793151_1	1249627.D779_2197	6.82e-99	310.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_582144_1	1123405.AUMM01000011_gene1346	3.85e-31	120.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,4HDDG@91061|Bacilli,26NSA@186821|Sporolactobacillaceae	91061|Bacilli	K	UTRA	yvoA	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
k59_384253_1	96561.Dole_0846	3.61e-89	277.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MIGI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM molybdopterin oxidoreductase	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_646337_1	1163617.SCD_n01283	9.47e-66	203.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2VR60@28216|Betaproteobacteria	28216|Betaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33,3.8.1.5	ko:K01563,ko:K11991	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223	RC00477,RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000,ko03016	-	-	-	Abhydrolase_1,MafB19-deam,TfoX_C
k59_646337_2	1000565.METUNv1_00896	4.24e-09	55.8	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,2VQT7@28216|Betaproteobacteria,2KWDI@206389|Rhodocyclales	206389|Rhodocyclales	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_941276_1	580332.Slit_0531	6.75e-84	257.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,44W64@713636|Nitrosomonadales	28216|Betaproteobacteria	T	SMART protein phosphatase 2C domain protein	pppL	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_318054_1	381666.H16_A2741	5.1e-70	235.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1K0FY@119060|Burkholderiaceae	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_680302_1	330214.NIDE3498	3.08e-34	135.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria	2|Bacteria	KT	transcription factor binding	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,GAF_3,HTH_8,Sigma54_activat
k59_26819_1	1206733.BAGC01000033_gene3912	1.09e-61	204.0	COG0439@1|root,COG0439@2|Bacteria,2I2S0@201174|Actinobacteria,4FWRD@85025|Nocardiaceae	201174|Actinobacteria	I	Biotin carboxylase C-terminal domain	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2,PP-binding
k59_516765_1	1458427.BAWN01000004_gene204	3e-33	126.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,4AB7Q@80864|Comamonadaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_353668_2	662755.CRES_0300	1.91e-18	84.3	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,22JYG@1653|Corynebacteriaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	thcA	GO:0003674,GO:0003824,GO:0004029,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0016620,GO:0016903,GO:0022607,GO:0033723,GO:0035821,GO:0043207,GO:0043933,GO:0044003,GO:0044085,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0075136	-	ko:K00138,ko:K18370	ko00010,ko00620,ko00640,ko01100,ko01110,ko01120,map00010,map00620,map00640,map01100,map01110,map01120	-	R00711,R10703	RC00047,RC00545	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_681339_1	933262.AXAM01000132_gene1921	3.58e-28	112.0	COG1662@1|root,COG1662@2|Bacteria	2|Bacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
k59_222632_1	714943.Mucpa_3350	1.55e-68	218.0	COG3958@1|root,COG3958@2|Bacteria,4NEI8@976|Bacteroidetes,1IP1N@117747|Sphingobacteriia	976|Bacteroidetes	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_93478_1	639282.DEFDS_0154	1.36e-46	162.0	COG0304@1|root,COG0304@2|Bacteria,2GEN9@200930|Deferribacteres	200930|Deferribacteres	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_353675_1	504472.Slin_2676	7.56e-05	45.1	COG0265@1|root,COG0265@2|Bacteria,4NGRE@976|Bacteroidetes,47MYU@768503|Cytophagia	976|Bacteroidetes	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_353675_2	742159.HMPREF0004_3580	2.29e-112	330.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2VHPA@28216|Betaproteobacteria,3T3AA@506|Alcaligenaceae	28216|Betaproteobacteria	S	Belongs to the pirin family	yhhW_2	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
k59_681346_1	330214.NIDE2085	1.26e-53	192.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
k59_1025470_2	1163617.SCD_n01531	2.05e-193	545.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria	28216|Betaproteobacteria	I	catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-acp	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817	2.3.1.179	ko:K00646,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_583203_1	1223410.KN050846_gene1673	2.84e-31	121.0	COG0429@1|root,COG0429@2|Bacteria,4NFGZ@976|Bacteroidetes,1HY3H@117743|Flavobacteriia	976|Bacteroidetes	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
k59_975047_1	134676.ACPL_5842	1.58e-37	145.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat,TIG
k59_27832_1	1163617.SCD_n02432	1.79e-14	75.1	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_319002_1	402626.Rpic_1188	3.02e-81	251.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1K25Z@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_517830_1	891968.Anamo_1289	2.81e-108	325.0	COG1012@1|root,COG1012@2|Bacteria,3TARM@508458|Synergistetes	508458|Synergistetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.81	ko:K15515	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
k59_517830_2	1032480.MLP_29190	2.1e-27	110.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4DNJX@85009|Propionibacteriales	201174|Actinobacteria	E	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_615006_1	344747.PM8797T_02964	6.08e-05	45.8	COG2095@1|root,COG2095@2|Bacteria,2J2AQ@203682|Planctomycetes	203682|Planctomycetes	U	MarC family integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
k59_615006_2	177439.DP2160	3.19e-51	171.0	COG0454@1|root,COG0456@2|Bacteria,1RA90@1224|Proteobacteria,42QTT@68525|delta/epsilon subdivisions,2WMN9@28221|Deltaproteobacteria,2MJTM@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.264	ko:K21935	-	-	R11701	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_9
k59_1005922_2	1254432.SCE1572_36420	2.49e-18	82.4	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,43BFC@68525|delta/epsilon subdivisions,2X6TQ@28221|Deltaproteobacteria,2Z3CQ@29|Myxococcales	28221|Deltaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_59493_1	52598.EE36_06638	3.13e-19	85.5	COG2153@1|root,COG2153@2|Bacteria,1MZHA@1224|Proteobacteria,2U94N@28211|Alphaproteobacteria,3ZXK5@60136|Sulfitobacter	28211|Alphaproteobacteria	S	FR47-like protein	elaA	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	-	ko:K02348	-	-	-	-	ko00000	-	-	-	Acetyltransf_10
k59_59496_1	864051.BurJ1DRAFT_0065	3.39e-110	328.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,2VPJI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Selenium-binding protein	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_774127_1	1189612.A33Q_0323	7.05e-19	86.3	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes	976|Bacteroidetes	Q	COG1228 Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_774127_2	745310.G432_09170	4.62e-14	74.7	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K29X@204457|Sphingomonadales	204457|Sphingomonadales	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_654527_2	1122134.KB893650_gene1620	1.9e-39	134.0	COG0346@1|root,COG0346@2|Bacteria,1RHRF@1224|Proteobacteria,1S7BW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_589151_1	321332.CYB_1248	1.26e-92	290.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1G1DF@1117|Cyanobacteria,1GZBH@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_882692_1	203122.Sde_1520	6.22e-09	56.6	COG0631@1|root,COG0631@2|Bacteria,1RFDT@1224|Proteobacteria,1SYCH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0631 Serine threonine protein phosphatase	pppA	-	3.1.3.16	ko:K11915	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko02044	-	-	-	PP2C_2
k59_262707_1	228410.NE1238	6.12e-66	226.0	COG2373@1|root,COG2373@2|Bacteria,1Q2SN@1224|Proteobacteria	1224|Proteobacteria	I	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
k59_589153_1	987059.RBXJA2T_09762	2.57e-75	236.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,1KJE2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_654530_1	257313.BP1116	3.62e-36	130.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria,3T2ED@506|Alcaligenaceae	28216|Betaproteobacteria	S	metal-dependent phosphoesterases (PHP family)	-	GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
k59_654530_2	314278.NB231_04455	2.21e-18	83.2	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,1S6CX@1236|Gammaproteobacteria,1X1X8@135613|Chromatiales	135613|Chromatiales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_882694_1	66875.JODY01000001_gene4591	1.81e-16	76.3	COG4290@1|root,COG4290@2|Bacteria,2IHPV@201174|Actinobacteria	201174|Actinobacteria	F	Ribonuclease	-	-	3.1.27.3	ko:K01167	-	-	-	-	ko00000,ko01000,ko03016,ko03019	-	-	-	Ribonuclease
k59_882694_2	887898.HMPREF0551_1841	5.82e-114	345.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1K0F2@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_197405_1	1121438.JNJA01000001_gene2487	8.24e-15	76.3	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2M859@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.5	ko:K20447	ko00760,ko01120,map00760,map01120	-	R01720	RC00589	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_197405_2	748449.Halha_1050	6.86e-19	87.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3WB8R@53433|Halanaerobiales	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	1.17.1.5	ko:K20447	ko00760,ko01120,map00760,map01120	-	R01720	RC00589	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_262718_2	686340.Metal_2367	5.17e-95	288.0	COG3385@1|root,COG3385@2|Bacteria,1NIWM@1224|Proteobacteria,1S5FT@1236|Gammaproteobacteria,1XFX0@135618|Methylococcales	135618|Methylococcales	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_980814_1	177437.HRM2_11010	2.52e-52	174.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,42S1V@68525|delta/epsilon subdivisions,2WNDR@28221|Deltaproteobacteria,2MJVB@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM Pilus assembly protein PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_589165_1	83219.PM02_09475	5.38e-63	201.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria,3ZX3D@60136|Sulfitobacter	28211|Alphaproteobacteria	I	CDP-alcohol phosphatidyltransferase	pssA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
k59_850194_1	1123514.KB905899_gene2011	9.83e-40	137.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,460J4@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_164730_1	626887.J057_05391	6.37e-30	111.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,1T09A@1236|Gammaproteobacteria,467F4@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1905 NADH ubiquinone oxidoreductase 24 kD subunit	-	-	1.6.5.3	ko:K00127,ko:K00334	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_164730_2	1000565.METUNv1_02521	1.3e-21	95.1	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIGR@28216|Betaproteobacteria,2KXTE@206389|Rhodocyclales	206389|Rhodocyclales	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Complex1_51K,NADH_4Fe-4S
k59_1012749_1	1123508.JH636439_gene874	2.97e-14	78.6	COG2936@1|root,COG2936@2|Bacteria,2IYPJ@203682|Planctomycetes	203682|Planctomycetes	E	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_589182_2	640510.BC1001_0864	6.74e-157	459.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2VJ8C@28216|Betaproteobacteria,1K27R@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_523899_1	136037.KDR22997	0.000135	49.3	KOG1584@1|root,KOG1584@2759|Eukaryota,38FPD@33154|Opisthokonta,3BEBC@33208|Metazoa,3CTZN@33213|Bilateria,41YRC@6656|Arthropoda,3SZ0I@50557|Insecta	33208|Metazoa	S	Sulfotransferase domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006805,GO:0006950,GO:0006952,GO:0008146,GO:0008150,GO:0008152,GO:0009410,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0016740,GO:0016782,GO:0042221,GO:0042742,GO:0043207,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0051923,GO:0070887,GO:0071466,GO:0098542	2.8.2.4	ko:K01016,ko:K01025	ko00140,map00140	-	R02350	RC00007,RC00128	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_1
k59_621861_1	1380390.JIAT01000010_gene4326	1.51e-59	201.0	COG1229@1|root,COG1229@2|Bacteria	2|Bacteria	C	Formylmethanofuran dehydrogenase subunit A	fhcA	GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0044237,GO:0044281	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
k59_980848_1	1125863.JAFN01000001_gene2404	3.61e-91	275.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2494	IGPS
k59_882743_1	338966.Ppro_3460	1.22e-43	163.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,43AN8@68525|delta/epsilon subdivisions,2X62F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
k59_784128_1	589865.DaAHT2_1251	6e-10	65.5	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,42QG6@68525|delta/epsilon subdivisions,2WNNB@28221|Deltaproteobacteria,2MQ3G@213118|Desulfobacterales	28221|Deltaproteobacteria	V	MatE	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_458452_1	330214.NIDE0571	3.64e-28	103.0	COG3169@1|root,COG3169@2|Bacteria	2|Bacteria	S	Protein conserved in bacteria	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
k59_458452_2	330214.NIDE0568	1.24e-83	268.0	COG0178@1|root,COG0178@2|Bacteria,3J0C7@40117|Nitrospirae	40117|Nitrospirae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1012755_1	754476.Q7A_684	2.99e-83	253.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,460FX@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_1012755_2	1265502.KB905946_gene1132	1.47e-17	80.1	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,4AAVK@80864|Comamonadaceae	28216|Betaproteobacteria	L	Exodeoxyribonuclease III xth	exoA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_34211_1	338963.Pcar_0699	5.19e-129	376.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,43U9V@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_882754_1	420662.Mpe_A2251	1.22e-20	86.3	2ATZM@1|root,31JJE@2|Bacteria,1RIFX@1224|Proteobacteria,2VSS3@28216|Betaproteobacteria,1KM95@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_360479_1	1415775.U729_2839	4.93e-35	137.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_262797_1	1123296.JQKE01000011_gene253	6.62e-05	50.4	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2VP12@28216|Betaproteobacteria,2KPHD@206351|Neisseriales	206351|Neisseriales	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_980875_1	1123392.AQWL01000002_gene1746	1.36e-109	319.0	COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,2VQJK@28216|Betaproteobacteria,1KS0C@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_556688_1	1049564.TevJSym_ab00640	1.24e-52	174.0	COG1136@1|root,COG1136@2|Bacteria,1RCXK@1224|Proteobacteria,1S7TZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	abc transporter atp-binding protein	attE	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_556688_2	1049564.TevJSym_ab00650	2.14e-40	147.0	COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	serine threonine protein kinase	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA,VWA_2
k59_132181_1	1424334.W822_12075	1.41e-12	68.6	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VNKP@28216|Betaproteobacteria,3T59B@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_132181_2	744985.HIMB59_00013900	1.64e-16	80.5	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,4BPTC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_915804_1	279238.Saro_2316	1.52e-89	286.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,2K0P9@204457|Sphingomonadales	204457|Sphingomonadales	M	Penicillin-binding Protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_66912_1	926569.ANT_27890	2.98e-25	103.0	COG3845@1|root,COG3845@2|Bacteria,2G625@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_66912_2	1380354.JIAN01000008_gene3498	7.31e-22	96.3	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,4F0NG@85016|Cellulomonadaceae	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
k59_719795_1	1532557.JL37_04945	1.05e-97	320.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_295338_1	1121035.AUCH01000019_gene2854	4.42e-97	295.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales	206389|Rhodocyclales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_66921_1	330214.NIDE2971	1.55e-18	82.4	COG3688@1|root,COG3688@2|Bacteria,3J0TU@40117|Nitrospirae	40117|Nitrospirae	S	YacP-like NYN domain	-	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
k59_66921_2	330214.NIDE2970	4.57e-77	236.0	COG0084@1|root,COG0084@2|Bacteria,3J0KM@40117|Nitrospirae	40117|Nitrospirae	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
k59_981833_2	1198452.Jab_1c16840	2.71e-32	114.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,474TV@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	sirA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_949427_1	1121918.ARWE01000001_gene3505	2.66e-66	214.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria,43TJR@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	hyaS	-	1.12.2.1,1.12.99.6	ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3332	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
k59_264005_1	880073.Calab_1111	1.99e-20	95.1	COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	pepN1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_492624_1	767434.Fraau_2421	2.21e-06	51.6	COG0745@1|root,COG0784@1|root,COG2203@1|root,COG5002@1|root,COG5278@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1XDBG@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
k59_198672_1	1097668.BYI23_A015570	1.9e-06	49.3	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2VJ1C@28216|Betaproteobacteria,1K27J@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_883911_1	768671.ThimaDRAFT_4574	1.98e-36	137.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1RNIF@1236|Gammaproteobacteria,1WX26@135613|Chromatiales	135613|Chromatiales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_883911_2	977880.RALTA_A1381	0.00095	46.2	COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2VIS6@28216|Betaproteobacteria,1K1ID@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_688542_1	880072.Desac_0289	7.26e-35	134.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2MQ9N@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_1434	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_166007_1	237368.SCABRO_00954	4.62e-96	296.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_917073_1	177437.HRM2_06450	1.4e-11	64.7	COG1148@1|root,COG1238@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1238@2|Bacteria,COG1908@2|Bacteria,1R68U@1224|Proteobacteria,42M71@68525|delta/epsilon subdivisions,2WKG0@28221|Deltaproteobacteria,2MJ02@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD
k59_917073_2	1220534.B655_1465	1.93e-05	49.3	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23NUK@183925|Methanobacteria	183925|Methanobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
k59_35478_1	653733.Selin_2402	1.67e-69	214.0	COG0560@1|root,COG0560@2|Bacteria	2|Bacteria	E	Phosphoserine phosphatase	thrH	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Hydrolase
k59_590461_1	1040989.AWZU01000024_gene6417	1.05e-78	246.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TSPW@28211|Alphaproteobacteria,3JVTH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_655851_1	626418.bglu_1g07940	7.61e-41	145.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,1K0U6@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_655851_2	580332.Slit_0653	3.17e-23	94.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2VIU0@28216|Betaproteobacteria,44V83@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Lumazine binding domain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_688560_1	479434.Sthe_1881	3.36e-31	120.0	COG1173@1|root,COG1173@2|Bacteria,2G6HB@200795|Chloroflexi,27XF3@189775|Thermomicrobia	2|Bacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_688560_2	748727.CLJU_c16410	0.000387	44.3	COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,25DGF@186801|Clostridia,36FGS@31979|Clostridiaceae	186801|Clostridia	M	mandelate racemase muconate lactonizing	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_361693_1	1565129.JSFF01000029_gene3020	1.3e-23	95.9	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,2QE5N@267890|Shewanellaceae	1236|Gammaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_459488_1	867845.KI911784_gene2289	5.23e-80	253.0	COG0154@1|root,COG0154@2|Bacteria,2G7WJ@200795|Chloroflexi,3771Y@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_721066_1	1414720.CBYM010000001_gene784	6.12e-25	111.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1TQXZ@1239|Firmicutes,249E6@186801|Clostridia,36DCZ@31979|Clostridiaceae	186801|Clostridia	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	BatA,GATase1_like,VWA,VWA_2,VWA_3
k59_688571_1	391593.RCCS2_15464	8.05e-110	334.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2P24W@2433|Roseobacter	28211|Alphaproteobacteria	I	COG3243 Poly(3-hydroxyalkanoate) synthetase	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_329165_1	330214.NIDE0529	7.28e-126	363.0	COG1834@1|root,COG1834@2|Bacteria	2|Bacteria	E	dimethylargininase activity	-	GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Amidinotransf,Saccharop_dh_N
k59_655878_1	648757.Rvan_1166	2.77e-86	258.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2TV7J@28211|Alphaproteobacteria,3N6R6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
k59_100744_1	933262.AXAM01000193_gene3045	5.7e-74	226.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NRE@68525|delta/epsilon subdivisions,2WM0E@28221|Deltaproteobacteria,2MJFH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_100744_2	177437.HRM2_48300	1.17e-19	88.2	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MIDP@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase for insertion sequences IS1326 IS1353 (IS21 IS408 IS1162 family protein)	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_329168_1	1163617.SCD_n01581	5.54e-26	107.0	COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA	selU	-	-	ko:K06917	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Rhodanese
k59_329168_2	1163617.SCD_n01755	2.54e-31	119.0	COG0726@1|root,COG0726@2|Bacteria,1N8Q4@1224|Proteobacteria,2VKEP@28216|Betaproteobacteria	28216|Betaproteobacteria	G	polysaccharide deacetylase	arnD	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_492690_1	1163617.SCD_n02111	1.09e-64	213.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome d1, heme	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_492690_2	1031711.RSPO_c00204	0.00054	43.1	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,1K982@119060|Burkholderiaceae	28216|Betaproteobacteria	C	cytochrome C	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
k59_35513_1	1122605.KB893647_gene269	1.18e-77	256.0	COG4775@1|root,COG4775@2|Bacteria,4NE6Z@976|Bacteroidetes,1IR22@117747|Sphingobacteriia	976|Bacteroidetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_981902_1	452637.Oter_1749	6.95e-22	97.4	COG1175@1|root,COG1175@2|Bacteria,46TU2@74201|Verrucomicrobia,3K9H3@414999|Opitutae	414999|Opitutae	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_337723_1	94624.Bpet1182	7.7e-46	161.0	COG0654@1|root,COG0654@2|Bacteria,1QXV0@1224|Proteobacteria,2VN0N@28216|Betaproteobacteria,3T6SQ@506|Alcaligenaceae	28216|Betaproteobacteria	CH	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_304380_1	885272.JonanDRAFT_1504	1.24e-70	236.0	COG4666@1|root,COG4666@2|Bacteria,3TA8D@508458|Synergistetes	508458|Synergistetes	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_958367_1	652103.Rpdx1_0909	7.69e-43	150.0	COG0520@1|root,COG0520@2|Bacteria,1MX5B@1224|Proteobacteria,2TVGK@28211|Alphaproteobacteria,3JTGG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_827980_2	543913.D521_2046	6.01e-20	85.5	2C256@1|root,2Z7SY@2|Bacteria,1Q75P@1224|Proteobacteria,2VUK3@28216|Betaproteobacteria,1KQWM@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors	pagP	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009279,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016409,GO:0016416,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044462,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.251	ko:K12973	ko01503,ko05133,map01503,map05133	M00724	R11223	RC00037,RC00041	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	OMP_b-brl,PagP
k59_958371_2	349124.Hhal_1811	3.59e-48	161.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1WW8F@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_697457_1	264198.Reut_A2857	2.87e-68	229.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,1JZN8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	ribonuclease II	rnb	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
k59_664679_1	76114.ebD83	4.28e-40	134.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,2KWPQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_664679_2	522306.CAP2UW1_0664	7.97e-08	53.9	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,1KQ6P@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_958374_1	1121438.JNJA01000002_gene3668	2.04e-42	149.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2M7UU@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_958374_2	1095769.CAHF01000011_gene2110	8.04e-25	103.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2VHJ7@28216|Betaproteobacteria,475RY@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	SpoVR like protein	spoVR1	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
k59_11675_1	519989.ECTPHS_02219	1.04e-43	154.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,1RSMW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_697461_1	98439.AJLL01000070_gene1455	1.19e-83	261.0	COG0044@1|root,COG0044@2|Bacteria,1G34Y@1117|Cyanobacteria,1JKQ7@1189|Stigonemataceae	1117|Cyanobacteria	F	Amidohydrolase family	-	-	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_925848_1	1380386.JIAW01000001_gene4660	6.2e-10	62.4	2DNRF@1|root,32YSD@2|Bacteria,2IAJC@201174|Actinobacteria,2366G@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_631486_1	633131.TR2A62_3647	7.49e-62	207.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Single-stranded-DNA-specific exonuclease (RecJ)	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_958384_1	1231190.NA8A_19218	7.52e-74	232.0	COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,2TSHF@28211|Alphaproteobacteria,43H6C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	MA20_28795	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_892024_1	887062.HGR_16014	2.29e-28	108.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,4ABUC@80864|Comamonadaceae	28216|Betaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_892024_2	323848.Nmul_A0816	1.35e-40	140.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,371YU@32003|Nitrosomonadales	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_697472_1	1123487.KB892857_gene2498	2.92e-147	428.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,2KV0S@206389|Rhodocyclales	206389|Rhodocyclales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_729909_2	1392838.AWNM01000097_gene129	1.55e-32	123.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2VHP9@28216|Betaproteobacteria,3T3XX@506|Alcaligenaceae	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_760138_1	1268068.PG5_12040	6.5e-59	189.0	COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,1T2CN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glycosyl Transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_599120_1	1163617.SCD_n02930	4.73e-188	528.0	COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2VRJN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_566674_1	305700.B447_01591	2.84e-88	263.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,2KV5Y@206389|Rhodocyclales	206389|Rhodocyclales	E	Acetolactate synthase small	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
k59_828015_1	1123256.KB907941_gene137	2.92e-58	193.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,1RNUB@1236|Gammaproteobacteria,1X5AX@135614|Xanthomonadales	135614|Xanthomonadales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_787245_1	279714.FuraDRAFT_2924	2.52e-34	124.0	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,2VU1H@28216|Betaproteobacteria,2KT9H@206351|Neisseriales	206351|Neisseriales	C	Dihaem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
k59_787245_2	269482.Bcep1808_6299	3.45e-11	62.4	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VQQ7@28216|Betaproteobacteria,1KI5G@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome B561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_501504_1	330214.NIDE3306	1.09e-70	219.0	COG2322@1|root,COG2322@2|Bacteria	2|Bacteria	S	membrane	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
k59_892035_1	1158292.JPOE01000002_gene1864	2.19e-85	277.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1KJJS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_13151_2	1123393.KB891316_gene1605	1.55e-22	91.3	COG0071@1|root,COG0071@2|Bacteria,1N1RF@1224|Proteobacteria,2VT18@28216|Betaproteobacteria,1KT32@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
k59_78552_1	572477.Alvin_0616	1.59e-55	191.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,1RPQA@1236|Gammaproteobacteria,1WWXJ@135613|Chromatiales	135613|Chromatiales	S	PFAM ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
k59_761323_1	1163617.SCD_n00875	8.65e-171	484.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria	28216|Betaproteobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_787753_1	330214.NIDE1931	6.5e-96	293.0	COG1894@1|root,COG1894@2|Bacteria,3J0WX@40117|Nitrospirae	40117|Nitrospirae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S
k59_698987_2	1121405.dsmv_2437	3.54e-46	155.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2MKKC@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_698987_3	933262.AXAM01000015_gene93	3.32e-58	187.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MHWF@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	aglX	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_78558_1	96561.Dole_2251	1.34e-51	176.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2MJB7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hmcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
k59_861178_1	1276756.AUEX01000002_gene636	1.32e-97	304.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,4AAAN@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_829501_1	1123072.AUDH01000019_gene2222	2.62e-57	184.0	COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TXAJ@28211|Alphaproteobacteria,2JWX2@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
k59_698992_1	1002672.SAR11G3_01300	4.55e-14	71.6	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2UBG9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_698992_2	335283.Neut_1332	7.13e-52	165.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,2VTY1@28216|Betaproteobacteria,373AC@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Ferredoxin	fdx	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
k59_666208_1	344747.PM8797T_05850	2.22e-80	247.0	COG1216@1|root,COG1216@2|Bacteria,2IZV9@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_959903_1	1123368.AUIS01000031_gene1422	6.5e-21	91.7	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_959903_2	1042377.AFPJ01000035_gene2638	1.79e-45	157.0	29B18@1|root,2ZY02@2|Bacteria,1REMG@1224|Proteobacteria,1S4B1@1236|Gammaproteobacteria,46AUF@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_731401_2	1288494.EBAPG3_7600	1.61e-53	178.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,371MS@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
k59_371426_1	522306.CAP2UW1_1590	9e-65	224.0	COG0296@1|root,COG1523@1|root,COG0296@2|Bacteria,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_371426_2	1123392.AQWL01000001_gene1649	2.7e-23	98.6	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,1KS15@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Carbohydrate phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphorylase
k59_402358_1	1463934.JOCF01000002_gene2984	2.49e-34	127.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_927365_1	945713.IALB_0011	2.45e-28	109.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_600584_1	1487923.DP73_20250	8.57e-70	226.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2613E@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_305781_1	335543.Sfum_2600	7.3e-68	219.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,2MSJJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_45506_1	640081.Dsui_0675	1.93e-40	144.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,2KWSF@206389|Rhodocyclales	206389|Rhodocyclales	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA
k59_45506_2	582744.Msip34_2808	5.07e-30	113.0	COG3087@1|root,COG3087@2|Bacteria,1RIU5@1224|Proteobacteria,2VTKT@28216|Betaproteobacteria,2KMUG@206350|Nitrosomonadales	206350|Nitrosomonadales	D	PFAM Sporulation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_78590_1	450851.PHZ_c0756	1.44e-51	181.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,2KHTP@204458|Caulobacterales	204458|Caulobacterales	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_991726_1	1245469.S58_62860	2.73e-34	128.0	COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria,3JRF8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase	suhB2	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_699029_1	983920.Y88_2995	3.63e-45	162.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2K0VT@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_927385_1	338963.Pcar_0272	7.73e-36	132.0	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,43SZ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Na+ dependent nucleoside transporter C-terminus	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
k59_78597_1	1537915.JU57_01460	4.87e-33	129.0	COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,42N4T@68525|delta/epsilon subdivisions,2YNUT@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_893434_1	859657.RPSI07_mp0938	1.56e-39	147.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1JZMH@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,TAT_signal
k59_893434_2	706587.Desti_0914	2.49e-64	218.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1QTTJ@1224|Proteobacteria,42NU9@68525|delta/epsilon subdivisions,2WKXG@28221|Deltaproteobacteria,2MRDM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2,Fer2,Fer2_2
k59_761363_1	330214.NIDE3245	4.09e-81	255.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_339242_1	159087.Daro_3373	3.67e-96	288.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,2KUWA@206389|Rhodocyclales	206389|Rhodocyclales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_731449_1	338966.Ppro_2789	3.91e-43	151.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,43VYT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_731449_2	338966.Ppro_2790	1.41e-13	72.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	nuoG-1	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3349	Fer2_4,Fer4_10,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_699054_1	1137799.GZ78_05890	6.52e-30	124.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria,1XIPK@135619|Oceanospirillales	135619|Oceanospirillales	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_600620_1	395961.Cyan7425_0893	1.79e-26	117.0	COG0464@1|root,COG0464@2|Bacteria,1G04V@1117|Cyanobacteria,3KFWV@43988|Cyanothece	1117|Cyanobacteria	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_503031_1	314285.KT71_02272	1.18e-82	261.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1J4NF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_371484_1	485916.Dtox_1167	6.09e-35	126.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,262G6@186807|Peptococcaceae	186801|Clostridia	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_13244_2	498211.CJA_1529	4.53e-05	44.7	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,1RQUQ@1236|Gammaproteobacteria,1FH6A@10|Cellvibrio	1236|Gammaproteobacteria	S	Protein of unknown function, DUF480	yceH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
k59_380684_2	404380.Gbem_1115	1.03e-20	90.5	COG3391@1|root,COG3391@2|Bacteria,1NW4P@1224|Proteobacteria,42Z3T@68525|delta/epsilon subdivisions,2WV9X@28221|Deltaproteobacteria,43VSW@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
k59_769808_1	926550.CLDAP_40150	2.09e-11	64.7	COG1164@1|root,COG1164@2|Bacteria,2G5UV@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_769808_2	251221.35210944	1.15e-15	80.5	COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,1G014@1117|Cyanobacteria	1117|Cyanobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_642569_1	1209989.TepiRe1_1537	2.21e-58	203.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_185445_1	1232437.KL661954_gene2353	8.65e-32	116.0	COG0437@1|root,COG0437@2|Bacteria,1NF8S@1224|Proteobacteria,42WBD@68525|delta/epsilon subdivisions,2WRT3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
k59_185445_2	1232437.KL661954_gene2351	1.28e-82	262.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,43BMM@68525|delta/epsilon subdivisions,2WJJV@28221|Deltaproteobacteria,2MHWI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_314617_1	522306.CAP2UW1_2887	8.29e-94	302.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1KR7N@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_769811_1	1500259.JQLD01000002_gene3245	1.61e-75	252.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4B9CX@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	efflux pump	MA20_01135	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_642577_1	411684.HPDFL43_13827	3.86e-35	135.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,43HYM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_475719_1	994573.T472_0200300	6.63e-16	80.5	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,36G8D@31979|Clostridiaceae	186801|Clostridia	G	Trap dicarboxylate transporter, dctm subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_970042_1	864073.HFRIS_016892	2.71e-74	241.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJ7X@28216|Betaproteobacteria,4732G@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	urtB	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_642578_1	1229205.BUPH_03528	3.88e-48	164.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,1K06B@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_642578_2	1123367.C666_14720	7.92e-09	57.4	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,2KVEN@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_247408_1	1232437.KL661958_gene2889	1e-110	337.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	bamH	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_277705_1	279714.FuraDRAFT_2446	1.85e-77	245.0	2E9CV@1|root,333KG@2|Bacteria,1NT11@1224|Proteobacteria,2W1DB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_902549_1	323097.Nham_0176	4.76e-115	340.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,3JSM6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_579722_1	977880.RALTA_A0218	1.51e-107	341.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1K4Q5@119060|Burkholderiaceae	28216|Betaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_771188_1	760117.JN27_07455	1.44e-105	312.0	COG3940@1|root,COG3940@2|Bacteria,1NKF0@1224|Proteobacteria,2WBIU@28216|Betaproteobacteria,475X0@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
k59_771190_1	1288494.EBAPG3_20440	9e-37	131.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,371SJ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_514365_2	102125.Xen7305DRAFT_00054060	2.98e-36	134.0	COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,3VJBK@52604|Pleurocapsales	1117|Cyanobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_743083_2	330214.NIDE3661	1.89e-10	60.8	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	CBS,GGDEF,PAS_9
k59_315963_1	207559.Dde_3599	2.92e-20	93.2	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M8CJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_382070_1	1123242.JH636434_gene4497	3.21e-43	151.0	COG5659@1|root,COG5659@2|Bacteria	2|Bacteria	L	transposition	insA	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_644079_1	573065.Astex_1372	1.28e-47	173.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,2KF49@204458|Caulobacterales	204458|Caulobacterales	L	DNA ligase D	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_611706_1	1454004.AW11_00194	1.72e-26	114.0	COG3264@1|root,COG3264@2|Bacteria,1QUDC@1224|Proteobacteria,2VJMG@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_24514_1	323848.Nmul_A2344	5.55e-167	484.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,372Q8@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_90080_1	373903.Hore_16050	7.68e-48	166.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3WB29@53433|Halanaerobiales	186801|Clostridia	GK	TIGRFAM ROK family protein	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
k59_248767_1	1121439.dsat_2665	9.89e-108	330.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2M8SY@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_743088_1	1234364.AMSF01000036_gene240	1.17e-104	317.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1X3Y7@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_219454_1	1245471.PCA10_50050	1.87e-72	231.0	COG1459@1|root,COG1459@2|Bacteria,1N8FA@1224|Proteobacteria,1RXYV@1236|Gammaproteobacteria,1YHSZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	NU	Type II secretion system (T2SS), protein F	gspF	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_971589_1	1128421.JAGA01000003_gene2723	8.97e-76	240.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_872405_1	1244869.H261_12286	1.38e-110	330.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
k59_382075_1	526222.Desal_2772	3.41e-18	83.6	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2M8QJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_382075_2	1121405.dsmv_1598	2.1e-149	435.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WJVC@28221|Deltaproteobacteria,2MINJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_382076_1	42565.FP66_13785	9.33e-63	216.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XHKJ@135619|Oceanospirillales	135619|Oceanospirillales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_350392_1	1054213.HMPREF9946_00777	4.18e-149	430.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_24532_1	1382306.JNIM01000001_gene83	3.73e-47	166.0	COG1921@1|root,COG1921@2|Bacteria,2G5VV@200795|Chloroflexi	200795|Chloroflexi	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
k59_186914_1	1236959.BAMT01000004_gene906	6.21e-12	65.1	COG0714@1|root,COG0714@2|Bacteria,1MUCP@1224|Proteobacteria,2VN99@28216|Betaproteobacteria,2KM7Y@206350|Nitrosomonadales	206350|Nitrosomonadales	S	associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA_3
k59_186914_2	748247.AZKH_1265	1.01e-32	118.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,2VUVV@28216|Betaproteobacteria,2KWJI@206389|Rhodocyclales	206389|Rhodocyclales	H	dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
k59_248782_1	998088.B565_3166	3.97e-06	51.6	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	fimT	-	-	ko:K08084,ko:K08085	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_677926_1	1120966.AUBU01000006_gene3213	5.03e-15	74.3	2AD1K@1|root,312PR@2|Bacteria,4NPRM@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_677926_2	1239962.C943_03297	5.23e-194	556.0	28ICA@1|root,2Z8EP@2|Bacteria,4NFBS@976|Bacteroidetes,47NDF@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6
k59_1023805_1	381666.PHG072	7.94e-28	114.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,1K2HP@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_903995_2	326297.Sama_0327	7.65e-36	129.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,2Q97Z@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Belongs to the UPF0758 family	radC	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_579768_1	1380394.JADL01000013_gene601	5.39e-62	215.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_841302_1	1123060.JONP01000012_gene2758	8.64e-96	288.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria,2JS33@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_90107_1	1265502.KB905930_gene1451	3.65e-57	183.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2VMC0@28216|Betaproteobacteria,4ABMQ@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_24541_1	1125863.JAFN01000001_gene2975	1.29e-35	132.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_219474_2	444862.E3SM03_9CAUD	1.9e-09	59.3	4QAND@10239|Viruses,4QVPE@35237|dsDNA viruses  no RNA stage,4QPBN@28883|Caudovirales,4QI03@10662|Myoviridae	10662|Myoviridae	S	Terminase DNA packaging enzyme	-	GO:0005575,GO:0032991,GO:0043493	-	-	-	-	-	-	-	-	-	-	-
k59_219474_3	1636182.A0A0F6R7F0_9CAUD	3.65e-43	158.0	4QHDM@10239|Viruses,4QRD0@28883|Caudovirales,4QI2W@10662|Myoviridae	10662|Myoviridae	S	Terminase-like family	-	GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016032,GO:0016043,GO:0016787,GO:0016788,GO:0019058,GO:0019068,GO:0019069,GO:0019072,GO:0019075,GO:0022607,GO:0032991,GO:0034641,GO:0043170,GO:0043493,GO:0044085,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0046483,GO:0046797,GO:0051704,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0098009,GO:1901360,GO:1902494,GO:1904949	-	-	-	-	-	-	-	-	-	-	-
k59_644117_1	580332.Slit_0112	6.42e-39	147.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,44V2I@713636|Nitrosomonadales	28216|Betaproteobacteria	U	PFAM type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_644117_2	1123255.JHYS01000001_gene1985	1.72e-07	51.6	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,2VSVR@28216|Betaproteobacteria,4ADYU@80864|Comamonadaceae	28216|Betaproteobacteria	NU	Pilus assembly protein	pilP	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_872436_1	762376.AXYL_06521	1.41e-66	211.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2W236@28216|Betaproteobacteria,3T8V9@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_872436_2	1278073.MYSTI_00645	3.15e-19	84.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,42VX5@68525|delta/epsilon subdivisions,2WRKZ@28221|Deltaproteobacteria,2Z1DA@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
k59_122160_1	261292.Nit79A3_0175	4.47e-80	244.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,371Y8@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_56281_1	266264.Rmet_4360	3.95e-143	421.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria,1KHV1@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_536081_2	1267534.KB906755_gene4271	1.46e-45	154.0	COG0217@1|root,COG0217@2|Bacteria,3Y2UW@57723|Acidobacteria,2JIJW@204432|Acidobacteriia	204432|Acidobacteriia	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_938980_1	933262.AXAM01000034_gene1563	1.02e-10	61.2	COG2885@1|root,COG3267@1|root,COG2885@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42PJ3@68525|delta/epsilon subdivisions,2WJF6@28221|Deltaproteobacteria,2MJ4S@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,OmpA
k59_971638_1	1123368.AUIS01000029_gene1287	1.96e-53	172.0	COG1371@1|root,COG1371@2|Bacteria,1N301@1224|Proteobacteria,1T17H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
k59_971638_2	525904.Tter_0374	7.83e-11	62.0	COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the RtcB family	rtcB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_186952_1	1127673.GLIP_2909	8.63e-87	275.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,469CU@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Inorganic H+ pyrophosphatase	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_219501_1	1049564.TevJSym_ah00180	2.84e-58	204.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1J4IX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_122167_2	344747.PM8797T_27954	3.84e-112	344.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66
k59_971641_1	1454004.AW11_01021	3.35e-54	192.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_9,dCache_1
k59_412101_1	33898.JRHJ01000010_gene5081	6.07e-30	118.0	COG4126@1|root,COG4126@2|Bacteria,2IDKD@201174|Actinobacteria	201174|Actinobacteria	E	flavin adenine dinucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
k59_938996_1	1459636.NTE_01414	1.85e-21	87.4	COG3269@1|root,arCOG01641@2157|Archaea	2157|Archaea	J	RNA-binding protein contains TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
k59_841345_1	1122138.AQUZ01000007_gene3007	2.37e-05	46.6	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria	2|Bacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_841345_2	1267535.KB906767_gene5393	1.32e-41	144.0	COG3415@1|root,COG3415@2|Bacteria,3Y8WI@57723|Acidobacteria	57723|Acidobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_33
k59_841345_3	196367.JNFG01000214_gene1233	1.32e-54	176.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,2VPNY@28216|Betaproteobacteria,1K7N5@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32,HTH_33
k59_350460_1	1121405.dsmv_3564	2.56e-100	300.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MI89@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_710795_1	269799.Gmet_1020	1.9e-58	204.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
k59_611784_1	693986.MOC_3825	5.01e-15	75.9	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2TS3I@28211|Alphaproteobacteria,1JX7E@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	amiC	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_5
k59_154956_1	420662.Mpe_A0265	9.29e-71	234.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1KJ17@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA topoisomerase III	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
k59_186972_1	1348657.M622_16845	1.9e-93	281.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,2KUZJ@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_549926_2	395495.Lcho_0523	5.85e-32	123.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,1KJRM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1034665_1	472759.Nhal_2573	1.1e-83	265.0	COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,1T2RP@1236|Gammaproteobacteria,1WZYU@135613|Chromatiales	135613|Chromatiales	S	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16
k59_802948_2	697282.Mettu_0563	4.62e-23	100.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RX1M@1236|Gammaproteobacteria,1XG7H@135618|Methylococcales	135618|Methylococcales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_802948_3	1536772.R70723_31110	6.51e-27	113.0	COG0642@1|root,COG0745@1|root,COG2972@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG2972@2|Bacteria,1TRIG@1239|Firmicutes,4HK60@91061|Bacilli,27624@186822|Paenibacillaceae	91061|Bacilli	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA,His_kinase,Response_reg
k59_802960_1	349521.HCH_06735	3.56e-76	252.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XHBW@135619|Oceanospirillales	135619|Oceanospirillales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_549970_1	1121405.dsmv_3107	3.57e-75	247.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MJ5T@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_549971_1	314285.KT71_03017	4.48e-18	84.7	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT6@1236|Gammaproteobacteria,1J7Y7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_803000_1	565045.NOR51B_1262	1.29e-108	337.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RR88@1236|Gammaproteobacteria,1J5WK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EU	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_803003_1	398527.Bphyt_0370	2.95e-75	229.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ75@28216|Betaproteobacteria,1K1AG@119060|Burkholderiaceae	28216|Betaproteobacteria	C	carbon monoxide dehydrogenase	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_803010_1	1487953.JMKF01000045_gene2731	5.71e-28	112.0	COG0129@1|root,COG0129@2|Bacteria,1G0KD@1117|Cyanobacteria,1H8V6@1150|Oscillatoriales	1117|Cyanobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_803010_2	570967.JMLV01000002_gene1804	3.98e-37	138.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2TV0X@28211|Alphaproteobacteria,2JPU1@204441|Rhodospirillales	204441|Rhodospirillales	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_803011_1	93220.LV28_09060	1.06e-26	109.0	COG2912@1|root,COG2912@2|Bacteria,1MVJQ@1224|Proteobacteria,2VMIR@28216|Betaproteobacteria,1K17Z@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
k59_1034757_1	1380394.JADL01000012_gene824	4.23e-51	170.0	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2U0PK@28211|Alphaproteobacteria,2JWBN@204441|Rhodospirillales	204441|Rhodospirillales	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_1034757_2	1123023.JIAI01000003_gene2634	7.18e-23	97.1	COG2159@1|root,COG2159@2|Bacteria,2GP75@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
k59_290755_1	1217656.F964_00232	1.13e-14	79.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,3NIHA@468|Moraxellaceae	1236|Gammaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iECs_1301.ECs5024,iG2583_1286.G2583_4866	Acyltransferase
k59_550098_1	1245471.PCA10_50640	5.76e-25	100.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,1YHPT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_1034806_1	631362.Thi970DRAFT_04814	5.87e-50	174.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_550109_1	309799.DICTH_0301	1.29e-38	147.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	acoA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381,ko:K21416,ko:K21417	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
k59_803157_1	1167006.UWK_02231	3.36e-64	217.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_290789_1	396588.Tgr7_3139	0.00089	47.4	COG5295@1|root,COG5295@2|Bacteria,1N8QZ@1224|Proteobacteria	1224|Proteobacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_290797_1	1049564.TevJSym_ca00050	5.5e-78	258.0	COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	MMPL family	VP1286	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_550146_1	945713.IALB_3104	2.04e-45	157.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	yoaV3	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1034843_1	379066.GAU_1887	4.05e-48	160.0	COG0669@1|root,COG0669@2|Bacteria,1ZTTQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_803182_1	330214.NIDE0233	6.29e-154	440.0	COG0649@1|root,COG0649@2|Bacteria,3J0FM@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
k59_290817_1	247490.KSU1_D0754	1.44e-105	318.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_5
k59_1034882_1	1150469.RSPPHO_02866	1.87e-28	105.0	COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,2UHB7@28211|Alphaproteobacteria,2JU0Y@204441|Rhodospirillales	204441|Rhodospirillales	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_1034882_2	1123059.KB823011_gene846	4.35e-26	101.0	COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,2UETR@28211|Alphaproteobacteria,43Y5P@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_1034882_3	1117647.M5M_19330	3.67e-24	97.8	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,1J5HN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG2111 Multisubunit Na H antiporter, MnhB subunit	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
k59_550268_2	316067.Geob_3166	2.65e-22	95.9	28WYN@1|root,33TG0@2|Bacteria,1NTYC@1224|Proteobacteria,42YTU@68525|delta/epsilon subdivisions,2WU4Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	6 heme-binding sites	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_803298_1	330214.NIDE1304	1.73e-146	450.0	COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_803305_1	395494.Galf_0059	8.63e-100	304.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,44V9S@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_21,Pyr_redox_2,Pyr_redox_3
k59_550296_2	246197.MXAN_4510	9.04e-67	222.0	COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,43BJ4@68525|delta/epsilon subdivisions,2WMCV@28221|Deltaproteobacteria,2YXIN@29|Myxococcales	28221|Deltaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_290954_1	395494.Galf_0337	7.6e-28	112.0	COG0812@1|root,COG1181@1|root,COG0812@2|Bacteria,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,44V42@713636|Nitrosomonadales	28216|Betaproteobacteria	M	D-ala D-ala ligase N-terminus	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_290954_2	948106.AWZT01000035_gene2448	5.56e-63	206.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,1K0U8@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1034963_1	1121405.dsmv_1956	3.17e-11	66.2	2FH6M@1|root,34912@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4203
k59_1034965_1	1458275.AZ34_09515	1.85e-13	68.9	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2VIR5@28216|Betaproteobacteria,4A9SI@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1034965_2	1458275.AZ34_09510	4.34e-184	521.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2VHXC@28216|Betaproteobacteria,4AB9R@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_290969_1	357808.RoseRS_1075	1.73e-39	150.0	COG0577@1|root,COG0577@2|Bacteria,2G68F@200795|Chloroflexi,376ZY@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1034987_1	945713.IALB_2113	2.77e-44	158.0	COG0323@1|root,COG0323@2|Bacteria	2|Bacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	2.1.1.37	ko:K00558,ko:K03572	ko00270,ko01100,ko03430,ko05206,map00270,map01100,map03430,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036,ko03400	-	-	-	DNA_mis_repair,HATPase_c,HATPase_c_3,MutL_C
k59_1034987_2	945713.IALB_2112	1.08e-14	73.6	COG1884@1|root,COG1884@2|Bacteria	2|Bacteria	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmA	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_803409_1	6238.CBG15088	9.63e-46	172.0	2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,40IET@6231|Nematoda,1M1Q3@119089|Chromadorea,40UDH@6236|Rhabditida	33208|Metazoa	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2,Endonuclease_7
k59_550395_1	1288494.EBAPG3_24380	9.15e-65	204.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,372H2@32003|Nitrosomonadales	28216|Betaproteobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant 1	gph	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_291059_1	1229909.NSED_09045	2.44e-47	157.0	arCOG08770@1|root,arCOG08770@2157|Archaea,41T2S@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_550430_1	1095769.CAHF01000015_gene2768	6.15e-63	214.0	COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,473VI@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34	mnmC	-	2.1.1.61	ko:K15461	-	-	R00601,R08702	RC00003,RC00053,RC00060,RC01483	ko00000,ko01000,ko03016	-	-	-	DAO,Methyltransf_30
k59_550430_2	187272.Mlg_1184	9.44e-42	142.0	2DN81@1|root,32W0Z@2|Bacteria,1MZF2@1224|Proteobacteria,1S9F7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_550430_3	644968.DFW101_2981	2.79e-09	57.8	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2M8IQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_803462_1	497321.C664_16610	6.75e-74	240.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,2KVEC@206389|Rhodocyclales	206389|Rhodocyclales	V	COG1132 ABC-type multidrug transport system, ATPase and permease components	-	-	-	ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_550445_1	996637.SGM_3380	1.85e-67	213.0	COG1024@1|root,COG1024@2|Bacteria,2I9VC@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_550451_1	1366050.N234_10470	1.57e-21	93.6	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2VKNE@28216|Betaproteobacteria,1KBP4@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_550451_2	1121035.AUCH01000006_gene759	2.2e-94	292.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,2KUHE@206389|Rhodocyclales	206389|Rhodocyclales	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1035076_1	1121405.dsmv_2372	4.36e-100	308.0	COG2414@1|root,COG2414@2|Bacteria,1R5AG@1224|Proteobacteria,42NHF@68525|delta/epsilon subdivisions,2WK3Z@28221|Deltaproteobacteria,2MIT9@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	bamB-1	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_550462_3	257310.BB4130	5.61e-06	47.0	COG0251@1|root,COG0251@2|Bacteria,1PETB@1224|Proteobacteria,2WA89@28216|Betaproteobacteria,3T7WQ@506|Alcaligenaceae	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_1035129_1	566466.NOR53_1616	5.9e-63	204.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,1RMUX@1236|Gammaproteobacteria,1J8EE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Isopropylmalate homocitrate citramalate	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_550555_1	259536.Psyc_1069	1.54e-09	58.9	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,3NKKW@468|Moraxellaceae	1236|Gammaproteobacteria	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_550555_2	1123393.KB891317_gene2372	1.33e-100	292.0	COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,2W1W6@28216|Betaproteobacteria,1KSRH@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Adenosine-5'-phosphosulfate reductase beta subunit	-	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4_9
k59_550566_1	504832.OCAR_7523	4.66e-106	322.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_550566_2	1411123.JQNH01000001_gene886	1.07e-68	227.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1035181_1	1122963.AUHB01000006_gene2435	5.37e-74	248.0	COG0457@1|root,COG0457@2|Bacteria,1Q3TC@1224|Proteobacteria,2U0J3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5107,TPR_16
k59_291267_1	1004785.AMBLS11_12410	2.27e-23	106.0	COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,1RPEA@1236|Gammaproteobacteria,46874@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	protein, homolog of phage Mu protein gp30	-	-	-	-	-	-	-	-	-	-	-	-	Phage_Mu_F
k59_1035205_2	1415780.JPOG01000001_gene167	2.11e-40	144.0	COG0526@1|root,COG4243@1|root,COG0526@2|Bacteria,COG4243@2|Bacteria,1QQS9@1224|Proteobacteria,1SKP7@1236|Gammaproteobacteria,1XA8Y@135614|Xanthomonadales	135614|Xanthomonadales	CO	Vitamin K epoxide reductase family	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
k59_291278_1	1329516.JPST01000021_gene2463	2.58e-61	205.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,4HEMP@91061|Bacilli,27BJ6@186824|Thermoactinomycetaceae	91061|Bacilli	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE,MgtE_N
k59_550626_1	1089544.KB912942_gene7198	4.63e-24	105.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,4DY4V@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Arabinose efflux permease family protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_550626_2	443598.AUFA01000039_gene5980	6.65e-77	242.0	COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,2U4JI@28211|Alphaproteobacteria,3K0JH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_550645_1	331869.BAL199_07133	2.46e-56	184.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,4BQQW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
k59_803736_1	105559.Nwat_1523	7.2e-119	377.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_291361_1	443152.MDG893_15497	4.08e-23	94.7	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,1RYSQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG4662 ABC-type tungstate transport system, periplasmic component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
k59_291361_2	187272.Mlg_2739	1.31e-59	192.0	COG1126@1|root,COG1126@2|Bacteria,1MWKQ@1224|Proteobacteria,1S5GB@1236|Gammaproteobacteria,1X0RK@135613|Chromatiales	135613|Chromatiales	P	ABC transporter	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
k59_550685_1	330214.NIDE2055	7.76e-80	253.0	COG0815@1|root,COG0815@2|Bacteria,3J0HA@40117|Nitrospirae	40117|Nitrospirae	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_815243_2	945713.IALB_2897	1.58e-76	231.0	COG0822@1|root,COG0822@2|Bacteria	2|Bacteria	C	iron-sulfur transferase activity	nifU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_815269_1	864051.BurJ1DRAFT_3964	4.28e-87	266.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2VKXM@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_815357_1	420662.Mpe_A2193	7.71e-37	138.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2VMAU@28216|Betaproteobacteria,1KMHE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_815423_1	1079460.ATTQ01000010_gene80	2.17e-23	102.0	COG1172@1|root,COG1172@2|Bacteria,1PSTG@1224|Proteobacteria,2V7KK@28211|Alphaproteobacteria,4BCQS@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_815478_1	522772.Dacet_2256	1.8e-21	97.8	COG0265@1|root,COG0308@1|root,COG3016@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG3016@2|Bacteria,2GFIT@200930|Deferribacteres	200930|Deferribacteres	EO	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2,Peptidase_M1
k59_815504_1	93220.LV28_03375	3.45e-12	64.7	COG2050@1|root,COG2050@2|Bacteria,1MYG1@1224|Proteobacteria,2VTQD@28216|Betaproteobacteria,1K6EA@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_815504_2	666681.M301_0403	6.03e-14	72.4	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_920949_1	935557.ATYB01000014_gene4531	5.16e-20	93.6	COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,2TV5V@28211|Alphaproteobacteria,4B7RN@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate guanylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,dCache_1
k59_920949_2	375286.mma_3172	2.1e-40	139.0	COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,2VSDN@28216|Betaproteobacteria,47754@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF	-	-	-	-	-	-	-	-	-	-	-	-	DUF411
k59_496565_1	757424.Hsero_0328	5.68e-85	261.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,472FG@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_887463_1	1192124.LIG30_3918	4.03e-56	199.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,1K2DM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1
k59_985610_1	1006000.GKAS_03013	7.79e-34	125.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,1RY9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	iclR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
k59_985610_2	999141.GME_18872	3.28e-58	195.0	COG3960@1|root,COG3960@2|Bacteria,1MV88@1224|Proteobacteria,1RW45@1236|Gammaproteobacteria,1XNQX@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the TPP enzyme family	-	-	4.1.1.47	ko:K01608	ko00630,ko01100,map00630,map01100	-	R00013	RC00899	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_397272_1	748247.AZKH_0305	3.52e-102	320.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,2KUYS@206389|Rhodocyclales	206389|Rhodocyclales	C	nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1014908_1	1500894.JQNN01000001_gene616	1.1e-72	230.0	COG0559@1|root,COG0559@2|Bacteria,1MVZ5@1224|Proteobacteria,2VJCG@28216|Betaproteobacteria,478G9@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_137274_1	1121127.JAFA01000013_gene2337	3.4e-104	311.0	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,1JZMG@119060|Burkholderiaceae	28216|Betaproteobacteria	C	oxidoreductase FAD NAD(P)-binding domain protein	ascD	-	1.17.1.1	ko:K00523,ko:K18248	ko00520,ko00627,ko01120,map00520,map00627,map01120	M00637	R00823,R00825,R03391,R03392	RC00192,RC00230	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1,Rieske
k59_137274_2	1100721.ALKO01000029_gene72	1.47e-10	62.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria,4AAC1@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_39242_1	1297865.APJD01000020_gene237	7.7e-35	129.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,3JW42@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_595632_2	1342299.Z947_120	1.9e-63	211.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_463391_1	653733.Selin_0330	8.16e-53	185.0	COG0480@1|root,COG0480@2|Bacteria	2|Bacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_463391_2	330214.NIDE2561	4.39e-26	105.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_234985_1	1000565.METUNv1_03446	1.3e-15	82.4	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,2KWW5@206389|Rhodocyclales	206389|Rhodocyclales	M	AsmA family	-	-	-	-	-	-	-	-	-	-	-	-	AsmA
k59_888720_1	644968.DFW101_2464	1.02e-49	174.0	COG1783@1|root,COG1783@2|Bacteria,1MVJB@1224|Proteobacteria,42YU8@68525|delta/epsilon subdivisions,2WUCP@28221|Deltaproteobacteria,2M8PF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6
k59_595641_1	945713.IALB_1499	8.67e-84	263.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_334345_2	1463900.JOIX01000002_gene5195	3.51e-17	81.6	COG4221@1|root,COG4221@2|Bacteria,2GP05@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_786076_1	1123392.AQWL01000005_gene3179	2.26e-38	136.0	COG0695@1|root,COG0695@2|Bacteria,1N7X3@1224|Proteobacteria,2VVPB@28216|Betaproteobacteria,1KSYP@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,Glutaredoxin
k59_73514_1	296591.Bpro_1218	2.64e-21	98.6	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2VHW1@28216|Betaproteobacteria,4AA7G@80864|Comamonadaceae	28216|Betaproteobacteria	M	surface antigen (D15)	tama	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_105929_1	555778.Hneap_0781	1.17e-66	210.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1WWSW@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1015635_1	909663.KI867149_gene3369	1.04e-12	75.5	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,2MQFK@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-2	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_73526_1	13035.Dacsa_0027	1.02e-05	53.1	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Fasciclin,HemolysinCabind,Peptidase_M14
k59_856460_1	7070.TC014829-PA	1.65e-53	197.0	2CMGD@1|root,2QQ9V@2759|Eukaryota,39B3J@33154|Opisthokonta,3BKG5@33208|Metazoa,3CTR5@33213|Bilateria,41V8V@6656|Arthropoda,3SQAF@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2
k59_269133_1	1048834.TC41_0334	4.02e-75	237.0	COG0667@1|root,COG0667@2|Bacteria,1TPIY@1239|Firmicutes,4HA4Q@91061|Bacilli,278WZ@186823|Alicyclobacillaceae	91061|Bacilli	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_954817_1	1499967.BAYZ01000104_gene3705	3.19e-83	261.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_40561_1	1005048.CFU_1252	5.41e-106	318.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,472ZF@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_661219_1	246197.MXAN_3431	5.29e-36	141.0	COG1538@1|root,COG1538@2|Bacteria,1MWB0@1224|Proteobacteria,42UCF@68525|delta/epsilon subdivisions,2WREI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
k59_661219_2	1415779.JOMH01000001_gene1472	5.44e-51	176.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1X3SD@135614|Xanthomonadales	135614|Xanthomonadales	Q	multicopper	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3,DUF4396
k59_954820_1	1049564.TevJSym_be00050	5.25e-91	276.0	COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	radical SAM protein	yhcC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
k59_856472_1	883126.HMPREF9710_01281	1.17e-31	124.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,473A1@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain, Two-component sensor kinase N-terminal	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_856472_2	395495.Lcho_1558	7.26e-28	108.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,1KIZ4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_986926_3	445686.E3SL93_9CAUD	3.45e-54	174.0	4QBKQ@10239|Viruses,4QVKF@35237|dsDNA viruses  no RNA stage,4QQM7@28883|Caudovirales,4QIAS@10662|Myoviridae	10662|Myoviridae	S	Bacteriophage translational regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_986926_6	1283076.M1ICV0_9CAUD	1.19e-113	338.0	4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses  no RNA stage,4QPJE@28883|Caudovirales,4QI9Y@10662|Myoviridae	10662|Myoviridae	S	ATPase family associated with various cellular activities (AAA)	-	GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704	-	-	-	-	-	-	-	-	-	-	-
k59_986926_7	1357714.A0A067XQV9_9CAUD	9.46e-47	161.0	4QB2Z@10239|Viruses,4QWQN@35237|dsDNA viruses  no RNA stage,4QPYN@28883|Caudovirales,4QHWJ@10662|Myoviridae	10662|Myoviridae	S	gp45 sliding clamp, C terminal	-	GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704	-	-	-	-	-	-	-	-	-	-	-
k59_986926_9	1357423.S5MCQ1_9CAUD	4.94e-112	335.0	4QBX5@10239|Viruses,4QVS2@35237|dsDNA viruses  no RNA stage,4QQR3@28883|Caudovirales,4QHZ6@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_986926_10	1493511.A0A0E3FRK0_9CAUD	2.25e-19	85.5	4QAZF@10239|Viruses,4QPH6@28883|Caudovirales,4QI08@10662|Myoviridae	10662|Myoviridae	S	Protein of unknwon function (DUF3310)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_334382_1	1120972.AUMH01000004_gene1462	1.41e-32	129.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli	91061|Bacilli	E	COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases	dapE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_563208_1	237368.SCABRO_00902	8.45e-74	235.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_954836_2	1536774.H70357_07690	3.22e-21	93.2	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,4H9MS@91061|Bacilli,26QTF@186822|Paenibacillaceae	91061|Bacilli	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.25,3.6.3.30,3.6.3.31	ko:K02010,ko:K02045,ko:K02052,ko:K11072,ko:K17240	ko00920,ko02010,ko02024,map00920,map02010,map02024	M00185,M00190,M00193,M00299,M00599	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.38,3.A.1.10,3.A.1.11,3.A.1.11.1,3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_2
k59_661231_1	153948.NAL212_2703	4.68e-25	102.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,3723M@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_661231_2	1286093.C266_00755	4.28e-38	136.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,1K3C5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SMART AAA ATPase	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
k59_432015_1	945713.IALB_3147	1.83e-81	263.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02336,ko:K06877,ko:K07501	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1
k59_40586_2	616991.JPOO01000001_gene3364	1.24e-15	76.3	COG0500@1|root,COG2226@2|Bacteria,4NP7E@976|Bacteroidetes,1I1YN@117743|Flavobacteriia	976|Bacteroidetes	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
k59_203750_1	1286093.C266_00180	1.45e-93	283.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1K25Z@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_498020_1	1479238.JQMZ01000001_gene1359	5.7e-19	82.8	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria,43XS8@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_498020_2	1040989.AWZU01000035_gene1778	7.17e-38	142.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_105990_1	945713.IALB_0619	3.86e-102	301.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
k59_40589_1	265072.Mfla_2082	8.85e-124	370.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,2KKQ1@206350|Nitrosomonadales	206350|Nitrosomonadales	J	TIGRFAM glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_824490_1	85643.Tmz1t_3555	1.02e-35	130.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,2VKSA@28216|Betaproteobacteria,2KYDG@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Radical_SAM
k59_824490_2	1121920.AUAU01000001_gene2206	3.52e-17	80.1	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria	2|Bacteria	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_856502_1	78245.Xaut_1954	7.52e-06	52.8	COG0030@1|root,COG0030@2|Bacteria,1R4E5@1224|Proteobacteria,2U55D@28211|Alphaproteobacteria,3EZ7M@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
k59_73571_1	187272.Mlg_0610	5.65e-12	62.4	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters	fis	GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
k59_73571_2	1217714.F975_01627	3.03e-21	94.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,3NIZ0@468|Moraxellaceae	1236|Gammaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_269177_1	56780.SYN_00994	8.41e-63	211.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2MQ9N@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_1434	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_171275_1	1485544.JQKP01000003_gene264	1.02e-104	313.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,44VKW@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_269178_1	330214.NIDE1315	1.09e-63	194.0	COG0185@1|root,COG0185@2|Bacteria,3J0MU@40117|Nitrospirae	40117|Nitrospirae	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_40603_2	1097668.BYI23_A001370	2.62e-19	81.3	2E6W9@1|root,331FT@2|Bacteria,1N6E1@1224|Proteobacteria,2VVIR@28216|Betaproteobacteria,1K8KB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3567)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3567
k59_334419_1	278957.ABEA03000094_gene4751	7.57e-39	132.0	COG4508@1|root,COG4508@2|Bacteria,46VH7@74201|Verrucomicrobia,3K7ZP@414999|Opitutae	414999|Opitutae	S	dUTPase	-	-	-	-	-	-	-	-	-	-	-	-	dUTPase_2
k59_8197_1	1144319.PMI16_00353	1.11e-50	170.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,472GR@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_986971_1	1408473.JHXO01000011_gene2969	4.76e-79	248.0	COG2403@1|root,COG2403@2|Bacteria,4NHIW@976|Bacteroidetes,2FNNX@200643|Bacteroidia	976|Bacteroidetes	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_235066_1	177437.HRM2_27830	1.02e-18	82.4	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2WPT4@28221|Deltaproteobacteria,2MK33@213118|Desulfobacterales	28221|Deltaproteobacteria	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
k59_301289_1	454957.IA64_08240	3.76e-28	110.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1X3I1@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_171289_1	1125973.JNLC01000010_gene1409	2.98e-106	323.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,3JZ96@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_824513_1	126957.SMAR008830-PA	9.72e-22	95.9	COG1960@1|root,KOG0137@2759|Eukaryota,38HSX@33154|Opisthokonta,3BG8S@33208|Metazoa,3D29E@33213|Bilateria,420J4@6656|Arthropoda	33208|Metazoa	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_824513_2	153948.NAL212_1480	1.91e-51	165.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,2VSZE@28216|Betaproteobacteria,373EC@32003|Nitrosomonadales	28216|Betaproteobacteria	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_628214_1	1144325.PMI22_02246	1.05e-52	182.0	COG1960@1|root,COG1960@2|Bacteria,1P8I7@1224|Proteobacteria,1S15X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_628214_2	270374.MELB17_13507	2.11e-49	171.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,465FA@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_726414_1	484770.UFO1_1182	0.000168	44.7	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,4H387@909932|Negativicutes	909932|Negativicutes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_726414_2	484770.UFO1_1184	3.23e-16	80.5	COG0845@1|root,COG1566@1|root,COG0845@2|Bacteria,COG1566@2|Bacteria,1UZZ7@1239|Firmicutes,4H3PK@909932|Negativicutes	909932|Negativicutes	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_269204_1	1235792.C808_04772	1.72e-25	102.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,27JJ4@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_398354_1	933262.AXAM01000001_gene349	1.97e-99	298.0	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,42N7B@68525|delta/epsilon subdivisions,2WJYE@28221|Deltaproteobacteria,2MI4D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type beta subunit	dsrB	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr
k59_637911_1	330214.NIDE3360	3.5e-47	168.0	COG0823@1|root,COG0823@2|Bacteria,3J0U9@40117|Nitrospirae	40117|Nitrospirae	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
k59_932534_1	1205680.CAKO01000038_gene1999	6.32e-65	207.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,2JQ9I@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0656 Aldo keto reductases, related to diketogulonate reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_508039_1	1158292.JPOE01000002_gene1842	1.42e-107	325.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,1KKFU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_834807_1	292415.Tbd_0077	9.44e-36	135.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,1KS6X@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome D1 heme domain	-	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_834807_2	1255043.TVNIR_1634	3.17e-11	63.9	COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,1RNSU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CK	Regulator of nitric oxide reductase transcription	nosR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K19339	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4,Fer4_5
k59_18282_1	344747.PM8797T_11114	5.75e-37	143.0	COG1966@1|root,COG1966@2|Bacteria,2IWZE@203682|Planctomycetes	203682|Planctomycetes	T	Carbon starvation protein	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
k59_115970_1	298654.FraEuI1c_4204	1.75e-40	142.0	COG1024@1|root,COG1024@2|Bacteria,2HEIS@201174|Actinobacteria,4ESHH@85013|Frankiales	201174|Actinobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_965167_1	570268.ANBB01000013_gene3002	3.84e-06	53.5	COG1802@1|root,COG1802@2|Bacteria,2GUMC@201174|Actinobacteria,4EKN9@85012|Streptosporangiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_344250_1	443143.GM18_3054	7.67e-50	179.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,43S5U@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_736699_1	671143.DAMO_0085	1.14e-24	101.0	COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria	2|Bacteria	E	Arginosuccinate synthase	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
k59_736699_2	330214.NIDE0484	1.79e-51	171.0	COG0078@1|root,COG0078@2|Bacteria,3J0G7@40117|Nitrospirae	40117|Nitrospirae	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_789691_1	768671.ThimaDRAFT_2117	2.79e-40	145.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales	135613|Chromatiales	S	Methyltransferase	-	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
k59_671449_1	1198232.CYCME_0324	3.65e-104	325.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,4608B@72273|Thiotrichales	72273|Thiotrichales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_275365_1	1454004.AW11_00388	4.8e-54	180.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,2VKSZ@28216|Betaproteobacteria	28216|Betaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
k59_605591_2	1042876.PPS_0141	3.69e-12	66.6	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,1RZ34@1236|Gammaproteobacteria,1YXF0@136845|Pseudomonas putida group	1236|Gammaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD TfdA	tauD	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_866305_1	1205680.CAKO01000038_gene1586	6.21e-48	171.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JRXA@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_898129_1	1348657.M622_15070	2.52e-67	215.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,2KV6F@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_898129_2	1036674.A28LD_1287	1.05e-23	97.8	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,2QF6V@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_310408_1	269084.syc0314_d	1.47e-13	69.7	COG1116@1|root,COG1116@2|Bacteria,1G1XM@1117|Cyanobacteria,1GZS2@1129|Synechococcus	1117|Cyanobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	nrtD	-	-	ko:K15578,ko:K15579	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	AAA_assoc_C,ABC_tran
k59_310408_2	1000565.METUNv1_00281	1.81e-51	171.0	COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2VH12@28216|Betaproteobacteria,2KV7F@206389|Rhodocyclales	206389|Rhodocyclales	P	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component	nasE	-	-	ko:K15577	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	BPD_transp_1
k59_704311_1	483219.LILAB_25040	2.61e-27	103.0	COG3791@1|root,COG3791@2|Bacteria,1RD31@1224|Proteobacteria,43DVM@68525|delta/epsilon subdivisions,2WYZY@28221|Deltaproteobacteria,2Z0G7@29|Myxococcales	28221|Deltaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_898131_1	1218074.BAXZ01000017_gene3553	2.83e-16	76.3	COG1722@1|root,COG1722@2|Bacteria,1PTYP@1224|Proteobacteria,2VVQV@28216|Betaproteobacteria,1K9WF@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
k59_898131_2	261292.Nit79A3_3212	7.41e-30	114.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2VHQV@28216|Betaproteobacteria,3724A@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_834852_1	1157634.KB912955_gene5147	1.2e-39	152.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
k59_18321_1	1229909.NSED_08685	1.3e-127	371.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
k59_18321_2	436308.Nmar_1605	1.25e-20	89.4	COG2262@1|root,arCOG00353@2157|Archaea,41SD4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_898134_1	864069.MicloDRAFT_00013770	6.15e-96	293.0	COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,2TR0R@28211|Alphaproteobacteria,1JX0W@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_898134_2	1713.JOFV01000005_gene2270	1.11e-30	113.0	COG4828@1|root,COG4828@2|Bacteria,2IQJ3@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
k59_275374_1	292415.Tbd_2433	3.38e-141	420.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,1KSEV@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Peptidase family M3	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_344294_1	1131553.JIBI01000016_gene618	3.82e-109	338.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,372UR@32003|Nitrosomonadales	28216|Betaproteobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_116021_1	436308.Nmar_1036	1.36e-64	199.0	arCOG08725@1|root,arCOG08725@2157|Archaea,41T3W@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_213503_1	1121405.dsmv_0958	7.73e-84	262.0	COG1061@1|root,COG1061@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2WJWA@28221|Deltaproteobacteria,2MHPY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	type III restriction protein res subunit	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
k59_83758_1	639283.Snov_1192	1.01e-31	117.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3F1UF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_671485_1	485917.Phep_2404	3.09e-122	363.0	COG0362@1|root,COG0362@2|Bacteria,4NG05@976|Bacteroidetes,1IWR3@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_406692_1	1038859.AXAU01000003_gene6195	7.94e-35	135.0	COG3203@1|root,COG3203@2|Bacteria,1R49B@1224|Proteobacteria	1224|Proteobacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF3573
k59_605626_1	945713.IALB_2923	3.47e-64	206.0	COG0679@1|root,COG0679@2|Bacteria	2|Bacteria	S	auxin-activated signaling pathway	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_932611_1	330214.NIDE1649	2.3e-32	123.0	2AAUK@1|root,3107C@2|Bacteria,3J1E0@40117|Nitrospirae	40117|Nitrospirae	S	LPP20 lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
k59_406700_1	1169144.KB910977_gene743	2.68e-48	169.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli,1ZD5E@1386|Bacillus	91061|Bacilli	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_406700_2	608538.HTH_0320	1.4e-14	73.2	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2G3I9@200783|Aquificae	200783|Aquificae	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_275389_1	395494.Galf_1195	5e-65	205.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2VHY7@28216|Betaproteobacteria,44VH1@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
k59_866357_1	880073.Calab_1910	1.86e-22	100.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,2NPIU@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,Response_reg
k59_471834_1	1320556.AVBP01000013_gene1653	3.58e-116	348.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,43GT5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	mccB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_376406_1	1163617.SCD_n00431	1.07e-54	181.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria	28216|Betaproteobacteria	O	peptidase, U32	yhbU	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_310468_1	1268622.AVS7_04222	6.83e-06	48.9	COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2VJIU@28216|Betaproteobacteria,4AC2K@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_310468_2	469383.Cwoe_4388	7e-18	85.1	COG0146@1|root,COG0146@2|Bacteria,2GNR7@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_1020764_1	743721.Psesu_2660	1.8e-25	110.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1X535@135614|Xanthomonadales	135614|Xanthomonadales	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C,PAP2,SNARE_assoc
k59_638008_1	96561.Dole_1874	1.05e-11	69.3	COG1148@1|root,COG1846@1|root,COG1148@2|Bacteria,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885,ko:K16886	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	MarR,MarR_2,Pyr_redox_2
k59_310470_1	1500890.JQNL01000001_gene2435	1.12e-21	93.6	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1X4G5@135614|Xanthomonadales	135614|Xanthomonadales	S	stress-induced protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_765742_1	1177928.TH2_02855	1.01e-57	200.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2JV23@204441|Rhodospirillales	204441|Rhodospirillales	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_736791_1	1449076.JOOE01000001_gene2223	1.87e-38	149.0	COG0642@1|root,COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
k59_573443_1	543728.Vapar_0838	0.000825	43.9	COG3181@1|root,COG3181@2|Bacteria,1NXBM@1224|Proteobacteria,2VM9B@28216|Betaproteobacteria,4ACCR@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_508157_1	1156919.QWC_04738	3.64e-70	230.0	COG1178@1|root,COG1178@2|Bacteria,1R0MN@1224|Proteobacteria,2VK7P@28216|Betaproteobacteria,3T76X@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_116080_1	1380394.JADL01000001_gene3040	1.07e-28	110.0	COG0559@1|root,COG0559@2|Bacteria,1NQYP@1224|Proteobacteria,2TSH6@28211|Alphaproteobacteria,2JRU1@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_116080_2	1144310.PMI07_004757	9.33e-15	75.9	COG4177@1|root,COG4177@2|Bacteria,1MYF5@1224|Proteobacteria,2TUHM@28211|Alphaproteobacteria,4B90X@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	MA20_07785	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_181270_1	69395.JQLZ01000007_gene1665	2.55e-80	244.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,2KIJ1@204458|Caulobacterales	204458|Caulobacterales	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_471866_1	298655.KI912266_gene5958	3.04e-89	273.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
k59_671559_1	2754.EH55_03425	0.00045	47.8	COG0760@1|root,COG0760@2|Bacteria,3TB0R@508458|Synergistetes	508458|Synergistetes	M	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2
k59_148806_3	85643.Tmz1t_3327	4.2e-50	160.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,2KWPF@206389|Rhodocyclales	206389|Rhodocyclales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_866404_1	2340.JV46_26700	5.13e-103	310.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	dgcB	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_441723_1	1158182.KB905031_gene2441	1.8e-23	94.4	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,1S98P@1236|Gammaproteobacteria,1WZIU@135613|Chromatiales	135613|Chromatiales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_441723_2	1122139.KB907872_gene2297	5.73e-19	84.7	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1XHGB@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
k59_406755_1	1380394.JADL01000010_gene4217	9.75e-22	97.8	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPT9@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_866413_1	331869.BAL199_12431	7.19e-88	273.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,4BRHR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_17100	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_311354_2	1297863.APJF01000020_gene2864	2.08e-44	157.0	COG0438@1|root,COG0438@2|Bacteria,1PDZE@1224|Proteobacteria,2TR1N@28211|Alphaproteobacteria,3JVFV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4
k59_737755_1	1459636.NTE_00009	1.3e-36	132.0	COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota	651137|Thaumarchaeota	F	aspartate carbamoyltransferase	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_705345_1	1156935.QWE_04313	1.88e-30	120.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,4BDTU@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_251131_1	1458275.AZ34_15930	1.4e-70	228.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9V8@80864|Comamonadaceae	28216|Betaproteobacteria	T	response regulator	yfhA	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_646804_1	935261.JAGL01000005_gene3359	1.44e-93	280.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria,43J47@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_1025202_1	1434325.AZQN01000003_gene2193	5.38e-10	61.2	COG2905@1|root,COG2905@2|Bacteria,4NP1Y@976|Bacteroidetes,47PPN@768503|Cytophagia	976|Bacteroidetes	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_773673_1	292415.Tbd_0697	1.58e-116	360.0	COG0532@1|root,COG3064@1|root,COG0532@2|Bacteria,COG3064@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1KRIR@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Translation-initiation factor 2	-	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_318507_1	1236689.MMALV_11360	1.89e-21	97.8	COG5598@1|root,arCOG03405@2157|Archaea,arCOG03406@2157|Archaea,2XUI8@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the transfer of a methyl group from trimethylamine to the corrinoid cofactor of MttC	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_157576_1	598467.BrE312_4087	3.48e-33	122.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,1RQB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_157576_2	1532557.JL37_23815	5.97e-47	158.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,2VK8V@28216|Betaproteobacteria,3T20V@506|Alcaligenaceae	28216|Betaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	gctA	-	2.8.3.12,2.8.3.5	ko:K01028,ko:K01039	ko00072,ko00280,ko00643,ko00650,ko01120,map00072,map00280,map00643,map00650,map01120	-	R00410,R04000,R05509	RC00012,RC00014,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_157576_3	1380394.JADL01000008_gene3557	6.96e-40	142.0	COG2267@1|root,COG2267@2|Bacteria,1MV7P@1224|Proteobacteria,2TSQ8@28211|Alphaproteobacteria,2JW5R@204441|Rhodospirillales	204441|Rhodospirillales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_222125_1	1122132.AQYH01000006_gene3363	5.75e-34	126.0	COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria,4BA48@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase	suhB2	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_844196_1	706587.Desti_4722	7.3e-36	137.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
k59_353184_1	1235457.C404_18540	1.07e-06	50.1	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1K2P6@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Malic enzyme	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
k59_189668_1	1163617.SCD_n02127	5.58e-55	194.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_124931_1	1305735.JAFT01000004_gene205	6.82e-36	130.0	COG4126@1|root,COG4126@2|Bacteria,1MWVG@1224|Proteobacteria,2U0MW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Asp Glu hydantoin racemase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
k59_124931_2	1532557.JL37_14865	1.13e-25	105.0	COG3181@1|root,COG3181@2|Bacteria,1R8PF@1224|Proteobacteria,2VP6F@28216|Betaproteobacteria,3T5FE@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_353189_1	1109445.AGSX01000152_gene3662	3.21e-05	45.8	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1Z1XI@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_353189_2	1229205.BUPH_02202	3.27e-59	194.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1K03I@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_582670_1	335283.Neut_2269	1.24e-71	238.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,373XP@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1025219_1	1121878.AUGL01000011_gene797	2.79e-61	203.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase, M16	-	-	2.7.7.6	ko:K00960,ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_450303_1	436308.Nmar_1299	2.91e-09	57.4	COG0642@1|root,COG0840@1|root,arCOG02344@2157|Archaea,arCOG02358@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	2.7.13.3	ko:K03406,ko:K07709	ko02020,ko02030,map02020,map02030	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,MCPsignal,dCache_1
k59_450303_2	1229909.NSED_00430	3.1e-76	231.0	COG0500@1|root,arCOG04347@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
k59_713596_1	580332.Slit_2699	6.32e-38	137.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,44VBF@713636|Nitrosomonadales	28216|Betaproteobacteria	U	PFAM Type II secretion system F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_713596_2	977880.RALTA_A2712	1.54e-66	213.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,1K2F5@119060|Burkholderiaceae	28216|Betaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_906719_1	266264.Rmet_1766	5.1e-38	140.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,2VN45@28216|Betaproteobacteria,1KGBI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Pyridoxal-dependent decarboxylase conserved domain	gadB	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
k59_906719_2	1121272.KB903289_gene4132	8.84e-61	204.0	COG0436@1|root,COG0436@2|Bacteria,2I9CX@201174|Actinobacteria,4DA33@85008|Micromonosporales	201174|Actinobacteria	E	Aminotransferase class I and II	-	-	4.1.1.12	ko:K09758	ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230	-	R00397,R00863	RC00282,RC00399,RC00400	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_58997_2	986075.CathTA2_1263	2.69e-22	97.4	COG1752@1|root,COG1752@2|Bacteria,1UUVB@1239|Firmicutes,4HDFQ@91061|Bacilli	91061|Bacilli	S	esterase of the alpha-beta hydrolase superfamily	ylbK	GO:0003674,GO:0003824,GO:0016787	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_189687_1	1298867.AUES01000001_gene1888	5.67e-56	192.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TRHJ@28211|Alphaproteobacteria,3JW9N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	MA20_44090	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_713602_1	1229205.BUPH_08235	4.15e-92	287.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria,1K341@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_92997_1	745014.OMB55_00015480	2.82e-23	98.2	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1J4Y7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2485	M20_dimer,Peptidase_M20
k59_680847_3	889378.Spiaf_2417	2.75e-17	81.3	COG0209@1|root,COG0209@2|Bacteria	2|Bacteria	F	ribonucleoside-diphosphate reductase activity	rtpR	-	1.1.98.6,1.17.4.1	ko:K00525,ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC
k59_27330_1	1348657.M622_03805	3.04e-16	77.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria,2KWEB@206389|Rhodocyclales	206389|Rhodocyclales	S	periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_27330_2	1163617.SCD_n02502	8.23e-76	231.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
k59_222166_1	1187851.A33M_4207	1.73e-68	216.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	gltA	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_353218_1	269482.Bcep1808_2346	1.45e-13	70.1	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2VHHT@28216|Betaproteobacteria,1K5AZ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_353218_2	243233.MCA2272	1.46e-22	94.7	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1XE7R@135618|Methylococcales	135618|Methylococcales	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_844238_1	330214.NIDE1736	3.4e-72	224.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
k59_27336_1	365044.Pnap_2938	6.33e-37	134.0	COG1305@1|root,COG1305@2|Bacteria,1MY5V@1224|Proteobacteria,2VKGI@28216|Betaproteobacteria,4AC73@80864|Comamonadaceae	28216|Betaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_27336_2	1278971.AOGF01000002_gene1237	2.1e-07	55.1	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1Y7YN@135625|Pasteurellales	135625|Pasteurellales	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_384752_1	1459636.NTE_00789	2.69e-53	178.0	COG1060@1|root,arCOG00656@2157|Archaea,41SEG@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Radical SAM	-	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
k59_537502_1	1121406.JAEX01000005_gene2872	1.43e-20	93.6	COG0607@1|root,COG0607@2|Bacteria,1RBXE@1224|Proteobacteria,42R9B@68525|delta/epsilon subdivisions,2WMY3@28221|Deltaproteobacteria,2M8B5@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_537502_2	1121413.JMKT01000001_gene1770	2.19e-11	61.6	COG2259@1|root,COG2259@2|Bacteria,1RIFW@1224|Proteobacteria,42SRS@68525|delta/epsilon subdivisions,2WPBA@28221|Deltaproteobacteria,2MBXR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	MauE
k59_124981_1	1286631.X805_32490	2.49e-82	258.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,1KJPR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1025238_1	395963.Bind_1945	1.42e-52	186.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,2TVI2@28211|Alphaproteobacteria,3NA3Z@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
k59_450341_1	1121405.dsmv_1679	8.33e-100	309.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2MICJ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_318576_1	1303518.CCALI_00836	6.84e-42	152.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria	2|Bacteria	H	GTP cyclohydrolase II activity	ribBA	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_27358_1	390235.PputW619_2460	8.8e-15	76.3	COG0683@1|root,COG2010@1|root,COG0683@2|Bacteria,COG2010@2|Bacteria,1R9N0@1224|Proteobacteria,1S351@1236|Gammaproteobacteria,1YXQ3@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Peripla_BP_6
k59_251198_1	1392491.JIAE01000001_gene190	2.71e-29	120.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,3WI29@541000|Ruminococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_844261_1	330214.NIDE3177	1.03e-42	147.0	COG0484@1|root,COG1948@1|root,COG0484@2|Bacteria,COG1948@2|Bacteria	2|Bacteria	L	resolution of meiotic recombination intermediates	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,ERCC4,Lsr2
k59_1025630_1	469381.Dpep_1065	2.99e-32	124.0	COG0647@1|root,COG0647@2|Bacteria,3TC1F@508458|Synergistetes	508458|Synergistetes	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like,NUDIX
k59_280471_1	338966.Ppro_3716	3.51e-32	119.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42R4P@68525|delta/epsilon subdivisions,2X5AT@28221|Deltaproteobacteria,43W1U@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_222978_1	264462.Bd2628	7.98e-84	259.0	COG0655@1|root,COG2146@1|root,COG0655@2|Bacteria,COG2146@2|Bacteria,1QY2E@1224|Proteobacteria,43C9S@68525|delta/epsilon subdivisions,2WTXI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Rieske
k59_942650_1	1288494.EBAPG3_9560	7.58e-204	575.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2VKNE@28216|Betaproteobacteria,372VG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_59815_1	765910.MARPU_01850	1.88e-67	212.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1WW6W@135613|Chromatiales	135613|Chromatiales	E	subfamily IA, variant 3	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD,HAD_2,Hydrolase
k59_615345_1	1123255.JHYS01000006_gene322	4.72e-35	130.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,4AA4E@80864|Comamonadaceae	28216|Betaproteobacteria	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_615345_2	1041142.ATTP01000015_gene6849	9.27e-10	59.7	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,4BC8P@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	AAA domain, putative AbiEii toxin, Type IV TA system	glnQ	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k59_975406_1	234267.Acid_4272	6.55e-25	108.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_845111_1	1485544.JQKP01000001_gene991	9.36e-48	160.0	2BDS5@1|root,327FW@2|Bacteria,1N15E@1224|Proteobacteria,2VUB3@28216|Betaproteobacteria,44WCK@713636|Nitrosomonadales	28216|Betaproteobacteria	S	NifQ	nifQ	-	-	ko:K15790	-	-	-	-	ko00000	-	-	-	NifQ
k59_158448_1	1384054.N790_05555	2.45e-92	290.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1X3GK@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_19,TPR_8
k59_222984_1	1231190.NA8A_12615	6.88e-108	325.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,43H5H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_746924_1	1121918.ARWE01000001_gene1952	8.01e-51	182.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,43RZ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Bacterial DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_385539_1	880072.Desac_0720	8.49e-87	269.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_93841_1	1227739.Hsw_1846	6.03e-19	92.4	COG2373@1|root,COG2373@2|Bacteria,4NGYZ@976|Bacteroidetes,47M8I@768503|Cytophagia	976|Bacteroidetes	S	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_647658_1	543728.Vapar_3673	7.03e-31	120.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria,2VJKU@28216|Betaproteobacteria,4AB6Q@80864|Comamonadaceae	28216|Betaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_59821_1	396513.SCA_0478	3.5e-08	56.2	COG3935@1|root,COG3935@2|Bacteria,1TSHD@1239|Firmicutes,4HIGY@91061|Bacilli,4GYXQ@90964|Staphylococcaceae	91061|Bacilli	L	Conserved phage C-terminus (Phg_2220_C)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_rep_org_N,Phg_2220_C
k59_451097_1	452637.Oter_4270	2.94e-29	118.0	COG4225@1|root,COG5434@1|root,COG4225@2|Bacteria,COG5434@2|Bacteria,46V95@74201|Verrucomicrobia,3K7RU@414999|Opitutae	414999|Opitutae	G	Belongs to the glycosyl hydrolase 28 family	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_28,Glyco_hydro_88
k59_451097_2	240292.Ava_0108	4.44e-22	94.0	COG0667@1|root,COG0667@2|Bacteria,1G3WV@1117|Cyanobacteria,1HTYB@1161|Nostocales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_681721_1	545694.TREPR_1316	8.11e-113	329.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
k59_385550_1	398767.Glov_1149	2.63e-30	119.0	COG0243@1|root,COG0243@2|Bacteria,1R5ZE@1224|Proteobacteria,42QK1@68525|delta/epsilon subdivisions,2WPX8@28221|Deltaproteobacteria,43V0Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_385550_2	555779.Dthio_PD1026	1.04e-43	148.0	COG0437@1|root,COG0437@2|Bacteria,1RCHX@1224|Proteobacteria,42S80@68525|delta/epsilon subdivisions,2X5D4@28221|Deltaproteobacteria,2MEPC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
k59_251881_2	706587.Desti_0924	6.7e-21	95.9	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,1PDZZ@1224|Proteobacteria,42M63@68525|delta/epsilon subdivisions,2WJDW@28221|Deltaproteobacteria,2MQXM@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA
k59_451106_1	338966.Ppro_3174	4.39e-54	177.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,43UK0@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_392907_1	477184.KYC_12648	6.97e-12	66.2	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,3T2ZE@506|Alcaligenaceae	28216|Betaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_392907_2	261292.Nit79A3_3096	1.39e-18	80.5	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2VR40@28216|Betaproteobacteria,37399@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_262476_1	394221.Mmar10_2501	2.16e-31	117.0	COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria,43XKS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
k59_849998_1	318586.Pden_0880	2.52e-76	235.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,2PV1J@265|Paracoccus	28211|Alphaproteobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_849998_2	1530186.JQEY01000010_gene2814	4.95e-12	64.3	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_654307_1	522373.Smlt0842	3.45e-41	146.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales	135614|Xanthomonadales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_491079_1	292415.Tbd_1001	2.86e-96	290.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,1KRGV@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_197187_1	238854.O36161_BPSYP	8.37e-68	224.0	4QBAK@10239|Viruses,4QY34@35237|dsDNA viruses  no RNA stage,4QQBQ@28883|Caudovirales	28883|Caudovirales	S	Bacteriophage T4-like capsid assembly protein (Gp20)	-	GO:0005575,GO:0019012	-	-	-	-	-	-	-	-	-	-	-
k59_1012662_1	1227272.HMPREF1556_00260	9.39e-30	126.0	COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,2FKYY@200643|Bacteroidia,22X50@171551|Porphyromonadaceae	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_425595_1	289376.THEYE_A1974	1e-53	188.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria	2|Bacteria	C	2Fe-2S iron-sulfur cluster binding domain	nqrF	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_523660_1	574966.KB898651_gene2140	4.05e-30	122.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_491093_2	485913.Krac_4181	3.14e-17	81.6	COG2084@1|root,COG2084@2|Bacteria	2|Bacteria	I	phosphogluconate dehydrogenase (decarboxylating) activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,F420_oxidored,NAD_binding_2
k59_719479_1	1459636.NTE_02607	2.67e-83	257.0	COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_850015_1	272568.GDI0602	7.48e-47	167.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_948029_1	4787.PITG_23229T0	3.11e-79	249.0	COG1007@1|root,KOG4668@2759|Eukaryota	2759|Eukaryota	C	NADH dehydrogenase (quinone) activity	ND2	GO:0003674,GO:0003824,GO:0003954,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010257,GO:0014069,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032279,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0035254,GO:0035255,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044456,GO:0044464,GO:0045202,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0072593,GO:0097458,GO:0098794,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0098984,GO:0099572,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADH_dehy_S2_C,Proton_antipo_M
k59_556399_1	999541.bgla_1g13390	2.35e-18	79.7	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2VQ16@28216|Betaproteobacteria,1K3AY@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_556399_2	580332.Slit_1057	1.13e-40	151.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,44V81@713636|Nitrosomonadales	28216|Betaproteobacteria	F	PFAM Carbamoyl-phosphate synthase L chain ATP-binding	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_654328_1	671143.DAMO_2706	2.76e-110	338.0	COG1009@1|root,COG1009@2|Bacteria,2NNM8@2323|unclassified Bacteria	2|Bacteria	CP	NADH-quinone oxidoreductase chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_392933_1	1161401.ASJA01000005_gene2453	4.87e-29	118.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,2TRM3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Patatin	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_229693_1	330214.NIDE0700	3.66e-189	530.0	COG0451@1|root,COG0451@2|Bacteria,3J0T9@40117|Nitrospirae	40117|Nitrospirae	M	NmrA-like family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
k59_458234_1	631362.Thi970DRAFT_01615	9.36e-43	152.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales	135613|Chromatiales	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_458234_2	765913.ThidrDRAFT_3049	8.47e-39	138.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1WWRH@135613|Chromatiales	135613|Chromatiales	G	Fructose-bisphosphate aldolase, class II, Calvin cycle subtype	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_751964_1	1459636.NTE_03208	1.84e-158	464.0	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_164510_1	1123393.KB891317_gene2400	1.34e-63	209.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,1KRCI@119069|Hydrogenophilales	119069|Hydrogenophilales	J	tRNA synthetases class II (D, K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_164510_2	463191.SSEG_00458	5.77e-08	54.7	COG0365@1|root,COG0365@2|Bacteria,2GM20@201174|Actinobacteria	201174|Actinobacteria	I	TIGRFAM Acetoacetyl-CoA synthase	acsA1	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_197217_1	1239962.C943_03302	8.44e-70	223.0	28JJ1@1|root,2Z9C5@2|Bacteria,4NJEU@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_131908_1	945713.IALB_2745	8.42e-96	288.0	COG0505@1|root,COG0505@2|Bacteria	2|Bacteria	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955,ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
k59_131913_1	84531.JMTZ01000006_gene3510	5.92e-41	146.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1X35R@135614|Xanthomonadales	135614|Xanthomonadales	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_262531_1	555088.DealDRAFT_0060	1e-30	124.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42JJH@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_491125_1	765914.ThisiDRAFT_2074	3.16e-77	240.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1WVY0@135613|Chromatiales	135613|Chromatiales	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_491125_2	469610.HMPREF0189_00749	2.65e-12	64.7	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VIJC@28216|Betaproteobacteria,1KK7A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_719511_2	648757.Rvan_3586	1.69e-93	279.0	COG4887@1|root,COG4887@2|Bacteria,1RKM1@1224|Proteobacteria,2U481@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1847)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1847
k59_392960_1	883.DvMF_2683	2.63e-19	94.0	COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
k59_719513_2	1123400.KB904758_gene2238	3.08e-08	53.9	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,460SA@72273|Thiotrichales	72273|Thiotrichales	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
k59_784057_1	765420.OSCT_2454	5.63e-66	218.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria	2|Bacteria	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short,adh_short_C2
k59_33968_1	941449.dsx2_1272	5.46e-66	217.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2X5JA@28221|Deltaproteobacteria,2MGRV@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
k59_458259_1	1121405.dsmv_2851	2.38e-66	222.0	COG0642@1|root,COG2205@2|Bacteria,1R5AX@1224|Proteobacteria,43DEA@68525|delta/epsilon subdivisions,2WJHY@28221|Deltaproteobacteria,2MJDF@213118|Desulfobacterales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS
k59_360296_1	1140.Synpcc7942_1581	5.06e-99	306.0	COG2866@1|root,COG2866@2|Bacteria,1G1CQ@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_392967_1	1232410.KI421426_gene1504	8.45e-47	154.0	2DXYD@1|root,3476T@2|Bacteria,1NCGD@1224|Proteobacteria	1224|Proteobacteria	S	Sugar efflux transporter for intercellular exchange	-	-	-	-	-	-	-	-	-	-	-	-	MtN3_slv
k59_263402_2	420662.Mpe_A0160	2.43e-54	184.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2VJR6@28216|Betaproteobacteria,1KMR3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_883342_1	1191523.MROS_1747	4.02e-58	191.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_328596_1	765914.ThisiDRAFT_1474	1.39e-94	303.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_557324_1	330214.NIDE1728	3.33e-132	392.0	COG0443@1|root,COG0443@2|Bacteria,3J0D2@40117|Nitrospirae	40117|Nitrospirae	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_295877_2	1304284.L21TH_2070	3.32e-67	211.0	COG0752@1|root,COG0752@2|Bacteria,1TPW8@1239|Firmicutes,24AU0@186801|Clostridia,36GQX@31979|Clostridiaceae	186801|Clostridia	J	Glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
k59_850823_1	1122134.KB893650_gene367	3.91e-33	125.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1XIMC@135619|Oceanospirillales	135619|Oceanospirillales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_850823_2	751994.AGIG01000028_gene1918	8.16e-107	316.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1J4Q3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
k59_655253_1	1502851.FG93_00150	3.61e-194	544.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3JUDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_132833_1	1266925.JHVX01000010_gene1318	7.13e-09	56.2	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,371N1@32003|Nitrosomonadales	28216|Betaproteobacteria	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_132833_2	580332.Slit_0259	1.32e-14	75.1	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria,44VQA@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Histidine kinase	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_948875_1	765911.Thivi_2316	1e-65	210.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales	135613|Chromatiales	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_850838_1	1209072.ALBT01000004_gene678	2.15e-09	63.9	COG2931@1|root,COG4254@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4254@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1FGNW@10|Cellvibrio	1236|Gammaproteobacteria	MQ	Cadherin-like	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,HemolysinCabind,PA14
k59_426458_1	85643.Tmz1t_2284	3.71e-81	265.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,2KV02@206389|Rhodocyclales	206389|Rhodocyclales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_34889_1	522306.CAP2UW1_2301	4.6e-64	196.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1KQQP@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_34889_2	1132855.KB913035_gene1146	2.56e-16	75.1	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,2KMB7@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Small MutS-related domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_393723_1	1288494.EBAPG3_13350	1.43e-64	213.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria,372K1@32003|Nitrosomonadales	28216|Betaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_557343_1	580332.Slit_2152	1.59e-26	100.0	2E1DK@1|root,32WSU@2|Bacteria,1N3VJ@1224|Proteobacteria,2VV0D@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_557343_2	545264.KB898744_gene2156	5.51e-110	333.0	COG2187@1|root,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
k59_328628_1	1122603.ATVI01000005_gene3040	4.78e-107	322.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_2098_1	1163617.SCD_n01151	1.79e-105	321.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,2VKHA@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_cB
k59_492064_1	335659.S23_04810	1.22e-23	105.0	COG2114@1|root,COG3850@1|root,COG2114@2|Bacteria,COG3850@2|Bacteria,1QW6N@1224|Proteobacteria,2TWQ3@28211|Alphaproteobacteria,3JU8D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,GAF_2,Guanylate_cyc,HAMP,dCache_1
k59_100134_1	1120966.AUBU01000006_gene3229	9.83e-24	102.0	COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,4NG54@976|Bacteroidetes,47MT2@768503|Cytophagia	976|Bacteroidetes	D	tail tape measure protein, TP901 family	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_883377_1	1124982.MSI_11630	1.32e-12	75.9	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2J5F4@203691|Spirochaetes	203691|Spirochaetes	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
k59_622522_1	864073.HFRIS_013354	8.19e-40	151.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,472TT@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_263443_1	1229909.NSED_00180	1.34e-80	258.0	COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_34898_1	396588.Tgr7_0041	7.41e-09	55.8	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales	135613|Chromatiales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_34898_3	305700.B447_16774	3.63e-23	91.3	COG1965@1|root,COG1965@2|Bacteria,1RH9A@1224|Proteobacteria,2VVS3@28216|Betaproteobacteria,2KWZ7@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the frataxin	cyaY	-	-	ko:K06202	-	-	-	-	ko00000	-	-	-	Frataxin_Cyay
k59_393732_1	96561.Dole_3185	5.42e-154	451.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MHKH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_426473_1	926569.ANT_05380	3.31e-88	270.0	COG1239@1|root,COG1239@2|Bacteria,2G5WJ@200795|Chloroflexi	200795|Chloroflexi	H	introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
k59_426473_2	926569.ANT_05390	2.61e-29	114.0	COG1240@1|root,COG1240@2|Bacteria,2G7UF@200795|Chloroflexi	200795|Chloroflexi	H	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_752660_2	1266914.ATUK01000001_gene812	6.25e-22	94.0	COG0030@1|root,COG0030@2|Bacteria,1QWDE@1224|Proteobacteria,1T5TK@1236|Gammaproteobacteria,1X2WH@135613|Chromatiales	135613|Chromatiales	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
k59_2121_1	1178825.ALIH01000005_gene190	3.75e-26	100.0	COG3070@1|root,COG3070@2|Bacteria,4NSGZ@976|Bacteroidetes,1I4CE@117743|Flavobacteriia	976|Bacteroidetes	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
k59_230520_1	1095769.CAHF01000006_gene1883	1.41e-112	346.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VNZD@28216|Betaproteobacteria,4764S@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_622535_1	555779.Dthio_PD2274	4.38e-71	241.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,42MEW@68525|delta/epsilon subdivisions,2WJX1@28221|Deltaproteobacteria,2M8X0@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM Malto-oligosyltrehalose synthase	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_720477_1	387092.NIS_0947	1.73e-22	100.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2YNH1@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	Protein of unknown function (DUF3417)	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_752671_1	640510.BC1001_2034	4.54e-44	155.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,1K3UX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_655296_1	313612.L8106_21829	7.29e-08	57.8	COG1940@1|root,COG1940@2|Bacteria,1G4PJ@1117|Cyanobacteria,1H8TR@1150|Oscillatoriales	1117|Cyanobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_784331_1	935948.KE386495_gene1368	3.42e-45	160.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,42FE4@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM MazG family protein	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
k59_622539_1	62928.azo1424	1.73e-67	210.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,2VQ09@28216|Betaproteobacteria,2KW25@206389|Rhodocyclales	206389|Rhodocyclales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_361126_1	987059.RBXJA2T_16907	2.94e-118	350.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1KJX9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_818599_1	1185876.BN8_03947	3.59e-24	108.0	COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47NJT@768503|Cytophagia	976|Bacteroidetes	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,TPR_12
k59_752678_1	330214.NIDE0545	2.85e-29	120.0	COG0745@1|root,COG2202@1|root,COG3290@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3290@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GGDEF,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE,dCache_1
k59_948921_1	472759.Nhal_3898	6.27e-21	90.1	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales	135613|Chromatiales	P	PFAM CBS domain	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_948921_2	1122236.KB905148_gene2168	3.94e-32	127.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,2KKPV@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_524616_1	375286.mma_2041	9.46e-92	292.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,4736M@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_10290_1	536019.Mesop_3119	6.27e-68	212.0	COG0765@1|root,COG0765@2|Bacteria,1RBVB@1224|Proteobacteria,2UC17@28211|Alphaproteobacteria,43JR8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	amino acid ABC transporter	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
k59_500099_1	859657.RPSI07_3081	2.05e-43	143.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,2VTY1@28216|Betaproteobacteria,1K7RZ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxin	fdx	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
k59_108059_1	1173023.KE650771_gene3864	8.48e-40	151.0	COG2202@1|root,COG2203@1|root,COG3284@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3284@2|Bacteria,COG4251@2|Bacteria,1GHBX@1117|Cyanobacteria	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
k59_858526_1	99598.Cal7507_5404	2.29e-05	47.8	COG0451@1|root,COG0451@2|Bacteria,1GJM5@1117|Cyanobacteria,1HIFZ@1161|Nostocales	1117|Cyanobacteria	GM	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_75664_1	1565129.JSFF01000015_gene19	3.97e-18	89.7	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,2QB0C@267890|Shewanellaceae	1236|Gammaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_140712_1	1121127.JAFA01000011_gene3788	3.63e-11	62.4	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VHRD@28216|Betaproteobacteria,1K28H@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	oxc	-	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100	-	R01908	RC00620	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_140712_2	391038.Bphy_3617	2.25e-125	367.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHYG@28216|Betaproteobacteria,1KGIR@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_400105_1	1101195.Meth11DRAFT_2482	9.12e-69	223.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VQSY@28216|Betaproteobacteria	28216|Betaproteobacteria	CH	PFAM monooxygenase FAD-binding	pcpB	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_858532_1	105559.Nwat_1578	1.05e-86	265.0	COG0438@1|root,COG0438@2|Bacteria,1MWSZ@1224|Proteobacteria,1RMQP@1236|Gammaproteobacteria,1WXA8@135613|Chromatiales	135613|Chromatiales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_108069_1	266265.Bxe_C0032	2.53e-06	48.9	COG3427@1|root,COG3427@2|Bacteria,1N4EQ@1224|Proteobacteria,2W4Q9@28216|Betaproteobacteria,1K52T@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
k59_108069_2	266265.Bxe_C0033	5.33e-60	194.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VIJR@28216|Betaproteobacteria,1K34U@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
k59_696054_1	1005048.CFU_0435	2.55e-31	120.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2VHC6@28216|Betaproteobacteria,472F6@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_10298_1	686340.Metal_1493	2e-157	465.0	COG2110@1|root,COG2110@2|Bacteria	2|Bacteria	P	phosphatase homologous to the C-terminal domain of histone macroH2A1	CP_0667	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	Macro
k59_500120_1	312153.Pnuc_0042	3.39e-58	182.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2VPZW@28216|Betaproteobacteria,1K762@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_500120_2	637389.Acaty_c0608	4.64e-14	70.5	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,2NC6D@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_43576_1	1535422.ND16A_2082	8.57e-83	257.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1RSMZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_141612_1	472759.Nhal_0566	4.41e-43	154.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_174250_1	349521.HCH_02381	3.74e-15	78.6	COG3206@1|root,COG3206@2|Bacteria,1QUY4@1224|Proteobacteria,1T31S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
k59_434863_1	589924.Ferp_1104	2.38e-34	123.0	COG0563@1|root,arCOG01046@2157|Archaea,2XTRG@28890|Euryarchaeota,246UX@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_434863_2	96561.Dole_0728	4.71e-41	147.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales	28221|Deltaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_337317_1	1163617.SCD_n01470	1.56e-50	183.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_337317_2	266265.Bxe_A1587	5.68e-43	148.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria,1K1VX@119060|Burkholderiaceae	28216|Betaproteobacteria	S	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_141614_1	1232410.KI421419_gene2512	9.05e-52	178.0	COG3875@1|root,COG3875@2|Bacteria,1R79Y@1224|Proteobacteria,42PGD@68525|delta/epsilon subdivisions,2WMB6@28221|Deltaproteobacteria,43T90@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_434864_1	497321.C664_12890	2.94e-78	241.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,2KUEQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_957936_1	247634.GPB2148_1990	2.2e-107	333.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,1RZZE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the GcvT family	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_891600_1	358220.C380_05915	7e-132	388.0	COG3391@1|root,COG3391@2|Bacteria,1MVXR@1224|Proteobacteria,2VJPF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	40-residue yvtn family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
k59_631102_1	1366050.N234_26510	2.25e-18	86.3	COG3181@1|root,COG3181@2|Bacteria,1NPUE@1224|Proteobacteria,2VHCN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_631102_2	1157708.KB907467_gene526	8.21e-14	68.2	COG0346@1|root,COG0346@2|Bacteria,1RDVE@1224|Proteobacteria,2VREX@28216|Betaproteobacteria,4AJID@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_76606_3	330214.NIDE0474	1.83e-22	94.4	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_729462_1	857087.Metme_0622	1.86e-53	171.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1XF3G@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
k59_729462_2	1121015.N789_11435	1.14e-38	135.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1X6GZ@135614|Xanthomonadales	135614|Xanthomonadales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_729462_3	396588.Tgr7_1564	4.06e-06	48.5	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_108987_1	926569.ANT_10240	1.13e-67	219.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi	200795|Chloroflexi	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1017283_1	1163617.SCD_n01475	2.85e-26	104.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SMART phosphoesterase PHP domain protein	-	GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
k59_1017283_2	580332.Slit_1629	3.05e-88	264.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VH4T@28216|Betaproteobacteria,44VHQ@713636|Nitrosomonadales	28216|Betaproteobacteria	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	yciO	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
k59_465980_1	395495.Lcho_3727	3.19e-104	303.0	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VJXP@28216|Betaproteobacteria,1KKF1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	fdhB	-	-	ko:K00124,ko:K07307	ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200	-	R00519,R09501	RC02555,RC02796	ko00000,ko00001,ko02000	5.A.3.3	-	-	Fer4_11,Fer4_7
k59_465980_2	62928.azo3482	7.2e-35	132.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,2KU82@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_11225_1	1082931.KKY_1233	1.8e-67	225.0	COG1593@1|root,COG4665@1|root,COG1593@2|Bacteria,COG4665@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_43596_1	335543.Sfum_1339	4.78e-93	285.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_206605_1	1410620.SHLA_3c001590	1.29e-38	142.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,4B9H7@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_891609_1	1187851.A33M_3194	4.18e-33	124.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_891609_2	269799.Gmet_2150	8.6e-37	131.0	COG1024@1|root,COG1024@2|Bacteria,1R8QP@1224|Proteobacteria,42S3Y@68525|delta/epsilon subdivisions,2WNXJ@28221|Deltaproteobacteria,43UFV@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	bamR	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_787090_1	557598.LHK_02274	1.29e-28	120.0	COG3614@1|root,COG3829@1|root,COG4191@1|root,COG3614@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VKEQ@28216|Betaproteobacteria,2KPI9@206351|Neisseriales	206351|Neisseriales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE,HATPase_c,HisKA,PAS_4
k59_787090_2	768671.ThimaDRAFT_2073	1.74e-22	92.8	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1X0NZ@135613|Chromatiales	135613|Chromatiales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_337348_2	1121115.AXVN01000025_gene963	4.48e-24	100.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24FZI@186801|Clostridia,3XZZI@572511|Blautia	186801|Clostridia	C	COG COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	cutS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_11240_1	643562.Daes_1345	3.73e-15	77.4	COG1418@1|root,COG1418@2|Bacteria,1MYFV@1224|Proteobacteria,42SP6@68525|delta/epsilon subdivisions,2WP9Z@28221|Deltaproteobacteria,2MBXN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_1017293_1	1125973.JNLC01000010_gene1417	1.96e-72	234.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,3JZ96@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_1017293_2	1352941.M877_29430	1.12e-49	173.0	COG2936@1|root,COG2936@2|Bacteria,2GKZH@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_237572_1	1236959.BAMT01000013_gene2977	7.94e-21	88.6	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,2VN69@28216|Betaproteobacteria,2KKCZ@206350|Nitrosomonadales	206350|Nitrosomonadales	P	ZIP Zinc transporter	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
k59_237572_2	1454004.AW11_00549	6.85e-09	54.3	2E3TT@1|root,32YR7@2|Bacteria,1N9R9@1224|Proteobacteria,2VW0P@28216|Betaproteobacteria,1KR3K@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_43619_1	1123393.KB891316_gene1810	2.88e-102	306.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VKI2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_925434_1	199310.c0502	9.08e-31	118.0	COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,1RMNN@1236|Gammaproteobacteria,3XN1U@561|Escherichia	1236|Gammaproteobacteria	J	May be involved in recombination	rdgC	GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009295,GO:0019219,GO:0019222,GO:0031323,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
k59_925434_2	768671.ThimaDRAFT_0084	3.94e-15	73.9	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,1S3Y4@1236|Gammaproteobacteria,1WYGC@135613|Chromatiales	135613|Chromatiales	S	Alpha/beta hydrolase family	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	-
k59_957980_1	1357423.S5MBW4_9CAUD	2.41e-25	107.0	4QAKE@10239|Viruses,4QUP7@35237|dsDNA viruses  no RNA stage	10239|Viruses	S	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_43626_1	1121405.dsmv_1442	1.1e-105	337.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MI79@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_891640_1	1123247.AUIJ01000009_gene3095	4.86e-78	237.0	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2U5H3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluE	-	5.4.99.20	ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
k59_697064_1	1168034.FH5T_16780	2.84e-100	307.0	COG1109@1|root,COG1109@2|Bacteria,4NFU7@976|Bacteroidetes,2FM0A@200643|Bacteroidia	976|Bacteroidetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	pgcA	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_827587_1	395494.Galf_0552	8.39e-61	210.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,44VNH@713636|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_827587_2	887327.HMPREF0476_1802	2.95e-70	214.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2VR2H@28216|Betaproteobacteria,2KQZX@206351|Neisseriales	206351|Neisseriales	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k59_827587_3	1208923.CKBE_00152	8.45e-16	73.2	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2VQ63@28216|Betaproteobacteria,1KPWV@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_859453_1	502025.Hoch_4792	7.72e-65	221.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YUPG@29|Myxococcales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_989913_1	1173024.KI912149_gene6263	2.25e-76	238.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1GKR9@1117|Cyanobacteria,1JMKR@1189|Stigonemataceae	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_697066_1	743721.Psesu_2442	1.05e-47	167.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1X31X@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf-QO	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
k59_76675_1	1286631.X805_20170	2.59e-14	74.3	COG4966@1|root,COG4966@2|Bacteria,1RH2G@1224|Proteobacteria,2VT5C@28216|Betaproteobacteria,1KMMA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type IV Pilus-assembly protein W	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
k59_76675_2	1163617.SCD_n02126	2.62e-17	79.7	COG4726@1|root,COG4726@2|Bacteria,1N9CE@1224|Proteobacteria,2VWPP@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1017318_2	189753.AXAS01000002_gene5160	7.22e-21	88.6	COG1051@1|root,COG1051@2|Bacteria,1QTT4@1224|Proteobacteria,2TWST@28211|Alphaproteobacteria,3JUB4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_337394_1	156889.Mmc1_0150	3.25e-46	167.0	COG3882@1|root,COG3882@2|Bacteria,1PNPC@1224|Proteobacteria,2TUY2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	HAD-superfamily phosphatase subfamily IIIC	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_631125_5	273526.SMDB11_3276	9e-05	44.7	COG2944@1|root,COG2944@2|Bacteria,1N05Y@1224|Proteobacteria,1SCTY@1236|Gammaproteobacteria,405GB@613|Serratia	1236|Gammaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31
k59_182775_1	1121035.AUCH01000003_gene1316	3.83e-05	51.2	COG0642@1|root,COG2199@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07679,ko:K07716	ko02020,ko04112,ko05133,map02020,map04112,map05133	M00477,M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	EAL,GAF,GAF_2,GGDEF,HATPase_c,HWE_HK,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3,dCache_3
k59_575018_1	1485545.JQLW01000012_gene1721	6.03e-50	170.0	293CN@1|root,2ZQV6@2|Bacteria,1RDZB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_85406_1	941449.dsx2_0195	2.03e-30	110.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_966867_1	566466.NOR53_2087	2.56e-110	333.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RYI9@1236|Gammaproteobacteria,1J9PP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_867938_1	385682.AFSL01000009_gene2499	3.94e-89	278.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,4NEXG@976|Bacteroidetes,2G2WR@200643|Bacteroidia,3XIJ9@558415|Marinilabiliaceae	976|Bacteroidetes	H	Carbon-nitrogen hydrolase	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_767158_1	1255043.TVNIR_3363	3.22e-58	198.0	COG4716@1|root,COG4716@2|Bacteria,1MVTV@1224|Proteobacteria,1RQMG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Myosin-crossreactive antigen	-	-	4.2.1.53	ko:K10254	-	-	-	-	ko00000,ko01000	-	-	-	MCRA
k59_867939_1	1188256.BASI01000005_gene1688	1.84e-88	276.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria,3FCP3@34008|Rhodovulum	28211|Alphaproteobacteria	S	Zn-dependent metallo-hydrolase RNA specificity domain	rnjA	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
k59_408083_1	1121035.AUCH01000014_gene2476	2.89e-44	164.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KW14@206389|Rhodocyclales	206389|Rhodocyclales	T	Cache 3/Cache 2 fusion domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9,dCache_2
k59_575030_1	224911.27352154	2.36e-46	151.0	COG2963@1|root,COG2963@2|Bacteria,1N06K@1224|Proteobacteria,2U9BK@28211|Alphaproteobacteria,3K068@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_Tnp_1
k59_575030_2	224911.27352155	1.5e-118	343.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,3JW35@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_182790_1	595537.Varpa_1862	1.03e-51	178.0	COG0477@1|root,COG2814@2|Bacteria,1MUXC@1224|Proteobacteria,2VP56@28216|Betaproteobacteria,4ABFY@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_673218_1	1286631.X805_24950	5.59e-54	181.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,1KJ2U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_673218_2	1304883.KI912532_gene708	1.53e-06	51.6	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KV59@206389|Rhodocyclales	206389|Rhodocyclales	I	poly(R)-hydroxyalkanoic acid synthase	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_345911_1	215803.DB30_3034	8.09e-56	183.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,2YU88@29|Myxococcales	28221|Deltaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_345911_2	1162668.LFE_0053	1.9e-10	60.8	COG0126@1|root,COG0126@2|Bacteria,3J0DE@40117|Nitrospirae	40117|Nitrospirae	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_966881_1	62928.azo2862	1.35e-17	80.9	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KW6R@206389|Rhodocyclales	206389|Rhodocyclales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_966881_2	864051.BurJ1DRAFT_3535	3.16e-79	246.0	COG0265@1|root,COG0265@2|Bacteria,1QWA4@1224|Proteobacteria,2VK6X@28216|Betaproteobacteria,1KKMS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_443232_1	338966.Ppro_2470	1.55e-45	159.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,42P7W@68525|delta/epsilon subdivisions,2WMHU@28221|Deltaproteobacteria,43SFF@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3473)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
k59_836557_2	330214.NIDE2133	3.53e-42	145.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_607254_1	640081.Dsui_0165	2.73e-107	319.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,2KUQC@206389|Rhodocyclales	206389|Rhodocyclales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_345915_2	1121939.L861_11025	1.97e-12	63.9	COG5662@1|root,COG5662@2|Bacteria,1NG37@1224|Proteobacteria,1ST5G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
k59_345915_3	713586.KB900536_gene1958	7.18e-12	66.2	COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_276199_1	395494.Galf_1572	1.59e-35	130.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_276199_2	85681.XP_006425070.1	0.000145	43.5	COG0214@1|root,KOG1606@2759|Eukaryota,37KWB@33090|Viridiplantae,3G7GA@35493|Streptophyta	35493|Streptophyta	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
k59_443238_1	261292.Nit79A3_3316	1.86e-45	165.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,371PH@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Soluble lytic murein transglycosylase L domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_509784_1	398527.Bphyt_0878	1.26e-115	340.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,1K19M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_673236_1	502025.Hoch_5086	2.2e-58	197.0	COG0715@1|root,COG2885@1|root,COG0715@2|Bacteria,COG2885@2|Bacteria,1R687@1224|Proteobacteria,42ZCB@68525|delta/epsilon subdivisions,2WTSU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MP	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,OmpA
k59_509789_1	1005395.CSV86_00247	3.06e-24	106.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	-	-	1.1.2.8,1.1.5.5,1.1.9.1	ko:K00114,ko:K17760,ko:K22473	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285,R09479	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_52062_1	557598.LHK_00530	2.87e-154	442.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,2KPT9@206351|Neisseriales	206351|Neisseriales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_244834_1	1121106.JQKB01000024_gene5097	1.37e-148	424.0	COG1609@1|root,COG1609@2|Bacteria,1R5GE@1224|Proteobacteria,2UC92@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
k59_934317_2	398525.KB900701_gene6821	1.23e-64	208.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,3JTAE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	MA20_01040	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k59_377958_1	1121405.dsmv_3465	9.9e-84	256.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria,2MHVP@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoH	-	-	ko:K03086,ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_215145_2	436308.Nmar_0363	1.26e-33	130.0	arCOG10350@1|root,arCOG10350@2157|Archaea	2157|Archaea	C	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_706079_1	1163617.SCD_n01883	1.23e-35	134.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,2WEVG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_706079_2	1163617.SCD_n01882	3.06e-89	265.0	COG1150@1|root,COG1150@2|Bacteria,1RHH3@1224|Proteobacteria,2W0PC@28216|Betaproteobacteria	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K16887	-	-	-	-	ko00000	-	-	-	Fer4_17
k59_509803_1	883078.HMPREF9695_01276	8.62e-65	210.0	COG0725@1|root,COG0725@2|Bacteria,1NACV@1224|Proteobacteria,2U20P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_52069_1	1117943.SFHH103_02426	1.05e-86	269.0	COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,4BB4U@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_639646_1	1163617.SCD_n02460	2.87e-17	77.8	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2VQ0H@28216|Betaproteobacteria	28216|Betaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_215150_1	68199.JNZO01000022_gene4419	8.6e-50	181.0	COG0646@1|root,COG0685@1|root,COG1410@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria	201174|Actinobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_899733_1	1096546.WYO_3299	5.42e-31	120.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,1JRBF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
k59_607290_1	999423.HMPREF9161_01576	1.12e-75	231.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,4H1V0@909932|Negativicutes	909932|Negativicutes	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_738514_1	485915.Dret_1496	3.29e-83	263.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_836601_1	443152.MDG893_15285	2.01e-72	237.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RQPW@1236|Gammaproteobacteria	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_899738_1	56780.SYN_02506	6e-25	101.0	COG5608@1|root,COG5608@2|Bacteria,1Q3JI@1224|Proteobacteria,42XEN@68525|delta/epsilon subdivisions,2WSWH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SMART Water Stress and Hypersensitive response	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
k59_117760_1	1288494.EBAPG3_9610	7.73e-50	161.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2VQ63@28216|Betaproteobacteria,372P2@32003|Nitrosomonadales	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_117760_2	420662.Mpe_A3446	4.82e-84	266.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,1KJ5X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_85490_2	1123392.AQWL01000001_gene1595	9.97e-43	145.0	COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,2VTZ3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_575097_1	281687.CJA08269b	1.39e-05	52.8	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda,1M1YY@119089|Chromadorea,40VAH@6236|Rhabditida	33208|Metazoa	L	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,gag-asp_proteas,rve,zf-CCHC
k59_150441_1	998088.B565_0131	1.83e-44	155.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,1Y3J9@135624|Aeromonadales	135624|Aeromonadales	P	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_8
k59_276227_1	748247.AZKH_0982	4.28e-89	277.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KU63@206389|Rhodocyclales	206389|Rhodocyclales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_182863_1	864051.BurJ1DRAFT_3989	2.29e-125	374.0	COG3960@1|root,COG3960@2|Bacteria,1MV88@1224|Proteobacteria,2VHT9@28216|Betaproteobacteria,1KK12@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the TPP enzyme family	gcl	-	4.1.1.47	ko:K01608	ko00630,ko01100,map00630,map01100	-	R00013	RC00899	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_738540_2	224324.aq_922	2.31e-44	160.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	nfnB	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_575104_1	1396418.BATQ01000039_gene6491	2.86e-121	382.0	28I8X@1|root,2Z8BQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_473250_1	1229909.NSED_08945	1.69e-19	92.0	COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota	651137|Thaumarchaeota	V	resistance protein	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
k59_473250_2	1229909.NSED_08950	7.36e-34	123.0	COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota	651137|Thaumarchaeota	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
k59_738545_1	663610.JQKO01000016_gene1588	5.75e-29	118.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve
k59_408160_1	1090320.KB900605_gene3000	1.91e-22	97.1	COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,2TRI4@28211|Alphaproteobacteria,2K38W@204457|Sphingomonadales	204457|Sphingomonadales	V	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_767238_1	1121875.KB907546_gene2451	2.16e-64	216.0	COG3118@1|root,COG3118@2|Bacteria,4PMAJ@976|Bacteroidetes,1IJPK@117743|Flavobacteriia	976|Bacteroidetes	O	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
k59_378007_1	1121468.AUBR01000034_gene1374	7.08e-93	288.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42FN9@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_509849_1	1230476.C207_05909	3.64e-32	121.0	COG1752@1|root,COG1752@2|Bacteria,1MX8Y@1224|Proteobacteria,2TVP9@28211|Alphaproteobacteria,3JS3R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_509849_2	426355.Mrad2831_6181	1.16e-34	139.0	COG0642@1|root,COG2203@1|root,COG3920@1|root,COG5000@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3920@2|Bacteria,COG5000@2|Bacteria,1NRP8@1224|Proteobacteria,2TYN2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_3
k59_533844_2	399739.Pmen_4080	3.46e-62	211.0	COG2199@1|root,COG2199@2|Bacteria,1R80Z@1224|Proteobacteria,1RZUV@1236|Gammaproteobacteria,1YD5M@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	yliF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	iSBO_1134.SBO_0726	GAPES2,GGDEF
k59_575120_1	153721.MYP_3548	1.84e-45	164.0	COG3858@1|root,COG3858@2|Bacteria,4NJZ6@976|Bacteroidetes,47QYP@768503|Cytophagia	976|Bacteroidetes	S	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	BNR_assoc_N,Glyco_hydro_18,Laminin_G_3
k59_276239_1	338966.Ppro_2905	8.9e-84	263.0	COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria,43T59@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_tran
k59_20105_1	375286.mma_0765	2.92e-18	85.1	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,472M9@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_20105_2	1245469.S58_51900	7.13e-25	98.6	COG2010@1|root,COG2010@2|Bacteria,1RIV2@1224|Proteobacteria,2U9C5@28211|Alphaproteobacteria,3JZ5J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
k59_117794_1	1380355.JNIJ01000041_gene5231	2.12e-40	145.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,3JTS4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_117794_2	1123368.AUIS01000009_gene2457	5.21e-56	177.0	COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S8VM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the thioredoxin family	trxA3	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_117794_3	1238182.C882_0258	9.37e-17	83.2	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,2JQW0@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_378021_1	991905.SL003B_0382	1.83e-23	96.7	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,4BPCB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	HMGL-like	mvaB	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_576081_1	228410.NE1712	3e-121	358.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,3723X@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_378869_1	1150864.MILUP08_41445	2.65e-37	139.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4DA1J@85008|Micromonosporales	201174|Actinobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_707060_3	1353529.M899_2407	1.63e-06	48.1	COG2036@1|root,COG2036@2|Bacteria	2|Bacteria	B	protein heterodimerization activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_28423_1	335543.Sfum_3099	3.98e-40	139.0	2E69N@1|root,330XJ@2|Bacteria,1NM8X@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_158685_1	748247.AZKH_4601	4.78e-75	249.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,2KV2P@206389|Rhodocyclales	206389|Rhodocyclales	T	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_714704_1	948106.AWZT01000011_gene2044	2.71e-59	192.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,1K3A8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	response regulator	basR_3	-	-	ko:K02483,ko:K07666,ko:K07774	ko02020,ko02024,map02020,map02024	M00453,M00457	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_94110_1	933262.AXAM01000002_gene557	1.53e-34	122.0	COG0071@1|root,COG0071@2|Bacteria,1RE2H@1224|Proteobacteria,42RP0@68525|delta/epsilon subdivisions,2WNC4@28221|Deltaproteobacteria,2MK0Y@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_126064_1	1163617.SCD_n02937	4.77e-55	181.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2VHC6@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_647907_1	357808.RoseRS_0054	6.21e-15	70.1	2A4IN@1|root,30T57@2|Bacteria,2GB1H@200795|Chloroflexi,377QX@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_647907_2	330214.NIDE3893	1.03e-35	125.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
k59_975699_1	1189619.pgond44_09366	5.92e-06	53.5	COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,1HYJD@117743|Flavobacteriia,4C2J6@83612|Psychroflexus	976|Bacteroidetes	S	Peptidase family C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
k59_1025777_1	177439.DP2116	3.81e-28	118.0	COG0531@1|root,COG0531@2|Bacteria,1PVV2@1224|Proteobacteria,433CQ@68525|delta/epsilon subdivisions,2WXZF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_583864_1	381666.H16_B0950	3.64e-72	221.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,HATPase_c_2,SpoIIE,dCache_1
k59_319542_1	935837.JAEK01000008_gene3457	1.4e-40	148.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,4H9YV@91061|Bacilli,1ZBY9@1386|Bacillus	91061|Bacilli	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrZ	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_28434_1	314278.NB231_08670	2.09e-92	288.0	COG0843@1|root,COG0843@2|Bacteria,1QDZV@1224|Proteobacteria,1RYXY@1236|Gammaproteobacteria,1X0EJ@135613|Chromatiales	135613|Chromatiales	C	PFAM cytochrome c oxidase subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_126066_1	383372.Rcas_0234	4.36e-98	293.0	COG3938@1|root,COG3938@2|Bacteria,2G5PY@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the proline racemase family	-	-	5.1.1.4,5.1.1.8	ko:K01777,ko:K12658	ko00330,ko01100,map00330,map01100	-	R01255,R03296	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
k59_223244_1	521098.Aaci_1053	1.34e-34	133.0	COG2801@1|root,COG2801@2|Bacteria,1UINX@1239|Firmicutes,4HDMT@91061|Bacilli,27AAT@186823|Alicyclobacillaceae	91061|Bacilli	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_647913_2	1123296.JQKE01000036_gene2155	2.46e-07	55.5	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,2KQ5J@206351|Neisseriales	206351|Neisseriales	C	Psort location Periplasmic, score	cyc	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_907793_1	497964.CfE428DRAFT_2921	1.11e-80	251.0	COG0438@1|root,COG0438@2|Bacteria,46VPZ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_280619_1	1163617.SCD_n01622	5.23e-49	168.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_28443_1	261292.Nit79A3_2082	3.79e-122	361.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria,3729N@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_583874_1	640081.Dsui_3535	1.36e-51	175.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,2KVN9@206389|Rhodocyclales	206389|Rhodocyclales	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_747209_1	748727.CLJU_c09650	9.61e-39	143.0	COG4627@1|root,COG4627@2|Bacteria,1UMZF@1239|Firmicutes,24UVP@186801|Clostridia	186801|Clostridia	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_747209_2	698761.RTCIAT899_CH10675	5.77e-29	114.0	COG2227@1|root,COG2227@2|Bacteria,1R68X@1224|Proteobacteria,2U54B@28211|Alphaproteobacteria,4BAK1@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_714726_1	76114.ebA4888	3.19e-126	370.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,2KVCI@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_714726_2	640512.BC1003_1019	9.21e-10	60.1	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,1K1GQ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_907798_1	485913.Krac_2179	1.68e-55	186.0	COG1904@1|root,COG1904@2|Bacteria,2G7Q1@200795|Chloroflexi	200795|Chloroflexi	G	Glucuronate isomerase	-	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
k59_615641_1	330214.NIDE1346	8.12e-104	308.0	COG1660@1|root,COG1660@2|Bacteria,3J0IK@40117|Nitrospirae	40117|Nitrospirae	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_252165_1	1285586.H131_04549	1e-27	114.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,3IXUZ@400634|Lysinibacillus	91061|Bacilli	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_942965_1	1191523.MROS_2504	1.42e-15	73.6	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	ytkL	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
k59_942965_2	945713.IALB_1592	9.99e-51	167.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	XK27_08075	-	-	-	-	-	-	-	-	-	-	-	DUF2062,Glycos_transf_2,GtrA,Lip_A_acyltrans
k59_158730_1	498211.CJA_0171	7.8e-35	134.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RMQA@1236|Gammaproteobacteria,1FHYI@10|Cellvibrio	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_876295_1	436308.Nmar_1015	1.11e-78	245.0	arCOG10350@1|root,arCOG10350@2157|Archaea	2157|Archaea	C	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_845411_1	713586.KB900536_gene595	1.66e-63	201.0	COG0500@1|root,COG2226@2|Bacteria,1QWW2@1224|Proteobacteria,1T361@1236|Gammaproteobacteria,1WY3X@135613|Chromatiales	135613|Chromatiales	Q	Protein of unknown function (DUF938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF938
k59_845411_2	582744.Msip34_1225	1.61e-16	76.6	COG0782@1|root,COG0782@2|Bacteria,1RHU5@1224|Proteobacteria,2W3NT@28216|Betaproteobacteria,2KMUI@206350|Nitrosomonadales	206350|Nitrosomonadales	K	PFAM transcription elongation factor GreA GreB	-	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB
k59_354369_1	261292.Nit79A3_1554	4.4e-57	198.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,3720I@32003|Nitrosomonadales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	-	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_876303_1	247639.MGP2080_07579	3.08e-17	88.6	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1J4N1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
k59_319578_1	1163617.SCD_n03010	1.19e-23	103.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_451390_1	1110502.TMO_1956	1.22e-96	296.0	COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,2JPTM@204441|Rhodospirillales	204441|Rhodospirillales	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_319582_1	945713.IALB_0042	9.14e-07	49.7	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_319582_2	945713.IALB_3203	2.29e-58	202.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_793792_1	261292.Nit79A3_1753	6.21e-137	402.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,3721Y@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_793792_2	1380394.JADL01000001_gene2477	3.13e-19	88.6	COG2079@1|root,COG2079@2|Bacteria,1R9ER@1224|Proteobacteria,2U4QI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_252180_1	443598.AUFA01000014_gene6964	8.06e-55	179.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2TRPS@28211|Alphaproteobacteria,3JREH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	MA20_40175	-	4.2.1.18,4.2.1.57	ko:K13766,ko:K13779	ko00280,ko00281,ko01100,map00280,map00281,map01100	M00036	R02085,R03493	RC00941,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_252180_2	235279.HH_1059	1.1e-10	58.9	COG2259@1|root,COG2259@2|Bacteria,1MZC7@1224|Proteobacteria,42TW9@68525|delta/epsilon subdivisions,2YPY5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_158749_1	314271.RB2654_01950	1.51e-05	47.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P450	MA20_16830	-	-	-	-	-	-	-	-	-	-	-	p450
k59_158749_2	1095769.CAHF01000021_gene943	7.94e-69	214.0	COG2755@1|root,COG2755@2|Bacteria,1MWT8@1224|Proteobacteria,2VVC1@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_223292_1	1123400.KB904749_gene725	4.14e-32	127.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,46005@72273|Thiotrichales	72273|Thiotrichales	I	Long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_28491_1	926569.ANT_11600	3.94e-103	305.0	COG0191@1|root,COG0191@2|Bacteria	2|Bacteria	G	fructose-bisphosphate aldolase activity	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_4960	F_bP_aldolase
k59_774723_2	1121013.P873_12075	1.52e-07	52.8	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_319591_1	1123229.AUBC01000007_gene251	2.43e-30	125.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2V7DP@28211|Alphaproteobacteria,3JXTQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg,dCache_1
k59_583925_1	247633.GP2143_15451	7.43e-06	47.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1J52T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_583925_2	1168067.JAGP01000001_gene2092	1.37e-05	48.5	2DSZ4@1|root,33I02@2|Bacteria,1NGMX@1224|Proteobacteria,1SGFG@1236|Gammaproteobacteria,461C4@72273|Thiotrichales	72273|Thiotrichales	S	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_583925_3	717774.Marme_4219	6.56e-19	83.2	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1XH68@135619|Oceanospirillales	135619|Oceanospirillales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_942996_1	1123487.KB892846_gene581	5.71e-56	187.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,2KU9I@206389|Rhodocyclales	206389|Rhodocyclales	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_975766_1	768671.ThimaDRAFT_0677	2e-87	271.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,1RMM2@1236|Gammaproteobacteria,1WXR4@135613|Chromatiales	135613|Chromatiales	G	hydrolase, family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
k59_451405_1	153948.NAL212_0879	8.08e-33	130.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,37258@32003|Nitrosomonadales	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_774731_1	945713.IALB_1698	3.3e-48	170.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_518538_1	1168059.KB899087_gene322	2.29e-74	237.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,3EXXT@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	SAF	MA20_06800	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
k59_1025820_1	436308.Nmar_1519	1.53e-86	257.0	COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota	651137|Thaumarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	-	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
k59_1025820_2	1229909.NSED_08355	3.33e-06	45.4	arCOG10588@1|root,arCOG10588@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_774740_1	1255043.TVNIR_2906	1.7e-40	152.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,1S0CA@1236|Gammaproteobacteria,1WXQT@135613|Chromatiales	135613|Chromatiales	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
k59_876339_1	344747.PM8797T_03995	1.73e-71	232.0	COG0008@1|root,COG0008@2|Bacteria,2IYSE@203682|Planctomycetes	203682|Planctomycetes	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_480401_1	285535.JOEY01000073_gene9814	4.96e-32	124.0	COG0329@1|root,COG0329@2|Bacteria,2I92Q@201174|Actinobacteria	201174|Actinobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_774747_1	1121468.AUBR01000005_gene65	4.79e-36	134.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,42GK1@68295|Thermoanaerobacterales	186801|Clostridia	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_943020_1	1218084.BBJK01000021_gene2230	9.41e-46	163.0	COG2232@1|root,COG2232@2|Bacteria,1R6Y7@1224|Proteobacteria,2VQI8@28216|Betaproteobacteria,1K09E@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
k59_682890_1	861299.J421_4211	2.78e-18	85.5	COG0457@1|root,COG0457@2|Bacteria,1ZSYB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
k59_584783_1	292415.Tbd_0230	3.85e-28	111.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_584783_2	1163617.SCD_n02800	2.39e-42	146.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	response regulator	algR	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_29304_1	570967.JMLV01000011_gene3324	3.59e-05	46.6	COG3963@1|root,COG3963@2|Bacteria,1RGMM@1224|Proteobacteria,2U84J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_29304_2	1120949.KB903357_gene4986	1.17e-40	152.0	COG4948@1|root,COG4948@2|Bacteria,2GKSK@201174|Actinobacteria,4D9NZ@85008|Micromonosporales	201174|Actinobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.2.2	ko:K01781	ko00627,ko01120,map00627,map01120	-	R03791,R04161	RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_943824_2	1500890.JQNL01000001_gene2000	5.63e-17	78.6	COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria,1X6CI@135614|Xanthomonadales	135614|Xanthomonadales	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_877106_1	75379.Tint_0336	4.64e-27	105.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,1KJYP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_877106_2	1005048.CFU_0757	7.17e-12	66.6	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,472NQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_794069_1	1449049.JONW01000009_gene4509	7.86e-13	68.6	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	MA20_26650	-	-	-	-	-	-	-	-	-	-	-	NMT1
k59_908612_1	411464.DESPIG_00634	5.45e-40	149.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2M91P@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
k59_908613_1	945713.IALB_1500	1.95e-39	146.0	COG4232@1|root,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	dsbD	-	1.8.1.8	ko:K04084,ko:K06196	-	-	-	-	ko00000,ko01000,ko02000,ko03110	5.A.1.1,5.A.1.2	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7
k59_914692_3	330214.NIDE0429	7.62e-79	241.0	2C1IB@1|root,2ZG3S@2|Bacteria	2|Bacteria	S	Proto-chlorophyllide reductase 57 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	PCP_red
k59_229015_1	292415.Tbd_1458	9.39e-32	127.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_392262_1	497964.CfE428DRAFT_2602	2.67e-99	301.0	COG1508@1|root,COG1508@2|Bacteria,46SDZ@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma-54 factor, RpoN	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_33160_1	1288494.EBAPG3_29850	2.89e-10	57.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2VSE6@28216|Betaproteobacteria,3737M@32003|Nitrosomonadales	28216|Betaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_33160_2	748247.AZKH_3993	2.93e-95	285.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,2KVIT@206389|Rhodocyclales	206389|Rhodocyclales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_914704_1	1183438.GKIL_4497	6.17e-66	211.0	COG0667@1|root,COG0667@2|Bacteria,1G4RF@1117|Cyanobacteria	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
k59_914704_2	713586.KB900536_gene2395	1.57e-134	390.0	COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,1S93R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
k59_718764_1	105559.Nwat_1509	5.63e-137	407.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria,1X0E1@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_457562_1	543728.Vapar_1728	3.66e-05	46.2	COG3181@1|root,COG3181@2|Bacteria,1QZZP@1224|Proteobacteria,2VJKC@28216|Betaproteobacteria,4ACZS@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_457562_2	1034943.BN1094_00881	4.44e-08	51.6	2AQ08@1|root,31F55@2|Bacteria,1QCIT@1224|Proteobacteria,1T89I@1236|Gammaproteobacteria,1JGET@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_457562_3	323848.Nmul_A1700	7.96e-85	265.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2VPE5@28216|Betaproteobacteria,372J2@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Saccharopine dehydrogenase C-terminal domain	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_163774_1	1304872.JAGC01000009_gene978	3.88e-161	459.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42MF8@68525|delta/epsilon subdivisions,2WJFH@28221|Deltaproteobacteria,2M8CG@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_98445_1	269799.Gmet_2293	6.36e-78	246.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,43TA3@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_588232_1	1408473.JHXO01000010_gene3677	2.12e-118	350.0	COG2262@1|root,COG2262@2|Bacteria,4NF0P@976|Bacteroidetes,2FM9T@200643|Bacteroidia	976|Bacteroidetes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_979990_1	232721.Ajs_2162	1.03e-96	304.0	COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,2VK07@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Glycosyl hydrolase family 65 central catalytic domain protein	-	-	2.4.1.64,2.4.1.8	ko:K00691,ko:K05342	ko00500,ko01100,map00500,map01100	-	R01555,R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_751379_1	285535.JOEY01000030_gene6985	3.72e-11	68.6	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_620876_2	203122.Sde_1232	1.7e-19	87.4	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,4647G@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG1448 Aspartate tyrosine aromatic aminotransferase	aspC	-	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_359625_1	1321782.HMPREF1986_00470	2.49e-19	94.4	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,2PRVR@265975|Oribacterium	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_33171_1	323848.Nmul_A0818	8.21e-152	439.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,371PJ@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_33171_2	261292.Nit79A3_1047	5.05e-91	270.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2VI59@28216|Betaproteobacteria,372C2@32003|Nitrosomonadales	28216|Betaproteobacteria	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
k59_816817_1	314287.GB2207_04089	1.92e-39	142.0	COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Secreted protein, containing von Willebrand factor (VWF) type	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_816817_2	1411685.U062_00813	4.68e-14	70.5	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_548_1	1459636.NTE_02626	1.36e-82	258.0	COG2141@1|root,arCOG02410@2157|Archaea	2157|Archaea	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_131113_1	570268.ANBB01000065_gene5783	1.92e-14	77.4	COG2972@1|root,COG2972@2|Bacteria,2I3R5@201174|Actinobacteria,4ER6B@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
k59_816828_1	330214.NIDE4272	3.72e-113	338.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	pilS	-	2.7.13.3	ko:K02668,ko:K10942	ko02020,ko05111,map02020,map05111	M00501,M00515	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
k59_718790_2	1122609.AUGT01000011_gene3568	4.59e-22	94.4	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_327054_1	696281.Desru_3815	9.31e-19	90.5	COG1906@1|root,COG1906@2|Bacteria,1V5AX@1239|Firmicutes,24JFK@186801|Clostridia,261ZN@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF401)	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
k59_327054_2	1121405.dsmv_2694	5.33e-08	53.9	COG1042@1|root,COG1042@2|Bacteria,1NU6B@1224|Proteobacteria,42NAU@68525|delta/epsilon subdivisions,2WJHX@28221|Deltaproteobacteria,2MIMR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_163801_1	383372.Rcas_1503	3.61e-09	60.8	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,2GBIC@200795|Chloroflexi,3780I@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_163801_2	316274.Haur_3061	8.37e-19	82.8	COG0745@1|root,COG0745@2|Bacteria,2GAJP@200795|Chloroflexi,37683@32061|Chloroflexia	32061|Chloroflexia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_914747_1	330214.NIDE1803	1.06e-19	87.8	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
k59_914747_2	330214.NIDE1804	3e-50	177.0	COG3696@1|root,COG3696@2|Bacteria,3J0ZR@40117|Nitrospirae	40117|Nitrospirae	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_783834_1	1034943.BN1094_03184	5.28e-79	258.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1JCU0@118969|Legionellales	118969|Legionellales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_229057_1	46234.ANA_C12206	7.83e-13	65.9	COG1487@1|root,COG1487@2|Bacteria,1G6RD@1117|Cyanobacteria,1HP9S@1161|Nostocales	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
k59_947401_1	927677.ALVU02000001_gene1806	5.6e-43	147.0	COG5485@1|root,COG5485@2|Bacteria,1GCKP@1117|Cyanobacteria	1117|Cyanobacteria	S	Ester cyclase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	SnoaL
k59_359649_1	639283.Snov_1607	3.6e-96	294.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria,3EZS5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_98486_1	1232437.KL662031_gene2579	6.68e-50	178.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_98486_2	880072.Desac_0312	6.48e-42	141.0	COG1908@1|root,COG1908@2|Bacteria,1RGF7@1224|Proteobacteria,42S3H@68525|delta/epsilon subdivisions,2WNTN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_392311_1	298654.FraEuI1c_4090	2.22e-21	94.7	COG1028@1|root,COG1028@2|Bacteria,2H3BV@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_816847_1	268746.Q58MZ0_BPPRM	2.08e-12	66.6	4QAX9@10239|Viruses,4QVNY@35237|dsDNA viruses  no RNA stage,4QPQH@28883|Caudovirales,4QHWN@10662|Myoviridae	10662|Myoviridae	S	T4 bacteriophage base plate protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_261777_1	450851.PHZ_c3263	1.61e-59	200.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TUA9@28211|Alphaproteobacteria,2KHMF@204458|Caulobacterales	204458|Caulobacterales	M	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
k59_980029_1	754476.Q7A_1574	9.55e-20	92.0	COG2199@1|root,COG3706@2|Bacteria,1QJQR@1224|Proteobacteria,1RR97@1236|Gammaproteobacteria,462AN@72273|Thiotrichales	72273|Thiotrichales	T	Diguanylate cyclase (GGDEF domain)	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3
k59_1012424_1	637905.SVI_4200	4.46e-09	58.5	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,2QABG@267890|Shewanellaceae	1236|Gammaproteobacteria	NU	type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE
k59_522965_1	631454.N177_1369	4.41e-76	250.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,1JNPY@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	B3/4 domain	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_490370_1	749414.SBI_04430	4.35e-10	59.7	COG0708@1|root,COG0708@2|Bacteria,2GKIS@201174|Actinobacteria	201174|Actinobacteria	L	exodeoxyribonuclease III	exoA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_490370_2	1131553.JIBI01000004_gene394	9.1e-74	227.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,2VH9U@28216|Betaproteobacteria,3722I@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_424978_1	313606.M23134_05281	1.01e-111	335.0	COG0626@1|root,COG0626@2|Bacteria,4PKE6@976|Bacteroidetes,47KC8@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	-	-	2.5.1.48,4.4.1.8	ko:K01739,ko:K01760	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_65883_1	296591.Bpro_5571	5.79e-100	306.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,4ACU4@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_261791_1	1173028.ANKO01000064_gene3082	1.51e-50	182.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H837@1150|Oscillatoriales	1117|Cyanobacteria	Q	Non-ribosomal peptide synthetase modules and related	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Formyl_trans_N,Methyltransf_12,PP-binding,PilZ
k59_980042_1	1120970.AUBZ01000010_gene2198	1.07e-72	237.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,4640S@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	yebA	-	-	-	-	-	-	-	-	-	-	-	OapA,OapA_N,Peptidase_M23
k59_718824_1	697282.Mettu_1219	3.11e-58	187.0	2AUHS@1|root,31K65@2|Bacteria,1QI00@1224|Proteobacteria,1TFSE@1236|Gammaproteobacteria,1XFCB@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_687284_1	1265505.ATUG01000001_gene4058	2.09e-96	290.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MTH@68525|delta/epsilon subdivisions,2WJQY@28221|Deltaproteobacteria,2MK6I@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM inner-membrane translocator	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_523962_1	768671.ThimaDRAFT_0873	7.74e-96	295.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales	135613|Chromatiales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_589253_1	375286.mma_1970	7.5e-121	373.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,472J6@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_687287_2	1038869.AXAN01000045_gene4441	1.17e-40	140.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2VSCN@28216|Betaproteobacteria,1K73W@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1178
k59_556715_1	857087.Metme_1759	6.25e-112	332.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1XETX@135618|Methylococcales	135618|Methylococcales	O	Belongs to the HypD family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_229988_1	883126.HMPREF9710_00334	3.25e-50	163.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,474DY@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
k59_229988_2	1123354.AUDR01000012_gene1901	6.67e-16	75.1	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,1KRE2@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_654659_1	556268.OFAG_00722	1.98e-14	72.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,473HF@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Squalene/phytoene synthase	hpnC	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_654659_2	580332.Slit_1436	4.33e-49	164.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,44V7C@713636|Nitrosomonadales	28216|Betaproteobacteria	I	Squalene/phytoene synthase	hpnD	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_491440_1	261292.Nit79A3_0841	2.07e-105	318.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,372MN@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_197517_1	864051.BurJ1DRAFT_2334	3.82e-106	332.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,2VJGX@28216|Betaproteobacteria,1KMR6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_915843_1	1205680.CAKO01000010_gene3929	6.41e-55	179.0	COG3618@1|root,COG3618@2|Bacteria,1QWWJ@1224|Proteobacteria,2TV8V@28211|Alphaproteobacteria,2JVWZ@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_915843_2	1538295.JY96_12850	2.05e-16	75.1	2DMP9@1|root,32SV1@2|Bacteria,1N17Y@1224|Proteobacteria,2VX5P@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3015
k59_1520_1	1278073.MYSTI_07949	3.81e-76	236.0	COG0395@1|root,COG0395@2|Bacteria,1PJQT@1224|Proteobacteria,43AQJ@68525|delta/epsilon subdivisions,2X64G@28221|Deltaproteobacteria,2Z390@29|Myxococcales	28221|Deltaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_948329_1	1396858.Q666_06260	4.67e-29	115.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,46560@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0030497,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1093,iAPECO1_1312.APECO1_174,iBWG_1329.BWG_0941,iE2348C_1286.E2348C_1185,iEC55989_1330.EC55989_1205,iECABU_c1320.ECABU_c13060,iECDH10B_1368.ECDH10B_1165,iECDH1ME8569_1439.ECDH1ME8569_1028,iECED1_1282.ECED1_1236,iECIAI39_1322.ECIAI39_2068,iECNA114_1301.ECNA114_1150,iECO103_1326.ECO103_1138,iECOK1_1307.ECOK1_1200,iECP_1309.ECP_1085,iECS88_1305.ECS88_1107,iECSE_1348.ECSE_1157,iECSF_1327.ECSF_0992,iECUMN_1333.ECUMN_1268,iECW_1372.ECW_m1201,iEKO11_1354.EKO11_2741,iETEC_1333.ETEC_1158,iEcDH1_1363.EcDH1_2554,iEcE24377_1341.EcE24377A_1214,iEcHS_1320.EcHS_A1215,iEcSMS35_1347.EcSMS35_2034,iEcolC_1368.EcolC_2508,iG2583_1286.G2583_1353,iJN746.PP_1914,iJO1366.b1093,iJR904.b1093,iSBO_1134.SBO_1970,iSFV_1184.SFV_1113,iSF_1195.SF1097,iSFxv_1172.SFxv_1249,iSSON_1240.SSON_1113,iS_1188.S1177,iSbBS512_1146.SbBS512_E2231,iUMN146_1321.UM146_11860,iUMNK88_1353.UMNK88_1363,iUTI89_1310.UTI89_C1218,iWFL_1372.ECW_m1201,iY75_1357.Y75_RS05710	adh_short_C2
k59_850298_1	1266908.AQPB01000053_gene595	1.25e-80	246.0	COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,1S02F@1236|Gammaproteobacteria,1WXYH@135613|Chromatiales	135613|Chromatiales	S	PFAM O-methyltransferase, family 3	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
k59_99522_1	1424334.W822_11570	3.88e-39	142.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2W92A@28216|Betaproteobacteria,3T5SM@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_621961_1	1144310.PMI07_003633	2.76e-11	68.9	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,4B80Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_132256_1	1123504.JQKD01000002_gene4047	3.63e-65	223.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,4AA2Y@80864|Comamonadaceae	28216|Betaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_956585_1	1040989.AWZU01000002_gene5414	2.56e-96	297.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,3JR67@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Acetolactate synthase	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_758752_1	1131266.ARWQ01000004_gene1417	7.45e-16	75.9	COG1909@1|root,arCOG04076@2157|Archaea,41SNQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
k59_758752_2	1459636.NTE_01706	3.07e-83	257.0	COG0489@1|root,arCOG01846@1|root,arCOG00585@2157|Archaea,arCOG01846@2157|Archaea,41SF1@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_890320_1	1437824.BN940_12716	4.04e-98	303.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,3T1TC@506|Alcaligenaceae	28216|Betaproteobacteria	T	GTP-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1016529_1	977880.RALTA_A1371	2.13e-15	72.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,1K0T3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_1016529_2	330214.NIDE2977	1.09e-87	266.0	COG1211@1|root,COG1211@2|Bacteria,3J18C@40117|Nitrospirae	40117|Nitrospirae	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_464928_1	596153.Alide_4100	5.95e-55	191.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,4AAB5@80864|Comamonadaceae	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_528841_1	1286631.X805_23180	1.93e-130	379.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,1KIW7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_172984_1	595460.RRSWK_00791	2.57e-25	106.0	COG1028@1|root,COG1028@2|Bacteria,2IXFA@203682|Planctomycetes	203682|Planctomycetes	IQ	with different specificities (related to short-chain alcohol	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1016539_1	420662.Mpe_A3262	4.29e-85	264.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,1KJH9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_890347_1	1104325.M7W_2651	5.86e-32	123.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,4HA9K@91061|Bacilli,4AZZ2@81852|Enterococcaceae	91061|Bacilli	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	-	-	-	-	-	-	-	-	-	Dus
k59_107740_1	644282.Deba_2966	6.27e-98	303.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2X85M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_597408_1	1123371.ATXH01000009_gene1052	1.9e-15	77.4	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,2GHF8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Mannose-6-phosphate isomerase, type	-	-	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_597408_2	926569.ANT_15990	7.61e-47	167.0	COG0550@1|root,COG0550@2|Bacteria,2G5ZR@200795|Chloroflexi	200795|Chloroflexi	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_336116_1	1163617.SCD_n02434	2.67e-75	253.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_695723_1	1120950.KB892768_gene5204	8.07e-61	208.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4DN37@85009|Propionibacteriales	201174|Actinobacteria	O	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_597414_1	859657.RPSI07_2477	1.31e-33	127.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,1K0P7@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
k59_597414_2	748247.AZKH_3557	6.19e-27	107.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2VIS1@28216|Betaproteobacteria,2KU90@206389|Rhodocyclales	206389|Rhodocyclales	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_662975_1	436308.Nmar_1267	4.29e-164	483.0	COG0294@1|root,COG1410@1|root,arCOG02029@2157|Archaea,arCOG02817@2157|Archaea,41SXT@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind
k59_107748_1	977880.RALTA_A2244	9.97e-65	219.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1K0FY@119060|Burkholderiaceae	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_107748_2	1288494.EBAPG3_2730	2.5e-126	364.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,3723Z@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Cytokinin riboside 5'-monophosphate phosphoribohydrolase	yvdD_2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_205432_1	1121127.JAFA01000095_gene2964	2.37e-147	427.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2VMZS@28216|Betaproteobacteria,1K35W@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_205434_1	344747.PM8797T_14716	1.27e-45	154.0	2DX6Z@1|root,343NZ@2|Bacteria	2|Bacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
k59_302873_1	460265.Mnod_4822	2.36e-75	234.0	COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria,2U0GD@28211|Alphaproteobacteria,1JSQ7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	PFAM formyl transferase domain protein	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_564999_1	1437824.BN940_12476	3.15e-25	103.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,3T23Q@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the formation of L-threonine from O-phospho-L-homoserine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_564999_2	580332.Slit_2218	8.11e-45	157.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,44V4Q@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_499803_1	177437.HRM2_18690	1.37e-78	248.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MHQQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_858216_1	1380394.JADL01000013_gene705	3.5e-73	231.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,2TRM8@28211|Alphaproteobacteria,2JW3Y@204441|Rhodospirillales	204441|Rhodospirillales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_858216_2	1175306.GWL_15840	5.14e-29	115.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,472MA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	ABC transporter	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1016568_1	330214.NIDE2073	2.74e-147	434.0	COG1389@1|root,COG1389@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
k59_336160_1	247490.KSU1_D0195	8.44e-80	250.0	COG1032@1|root,COG1032@2|Bacteria,2IXHH@203682|Planctomycetes	203682|Planctomycetes	C	Domain of unknown function (DUF4070)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_75834_1	945713.IALB_2927	6.28e-28	116.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CBM_6,DUF1565,PDZ_2,Trypsin_2
k59_858677_1	667632.KB890173_gene3895	6.53e-81	248.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2VGZK@28216|Betaproteobacteria,1K26Y@119060|Burkholderiaceae	28216|Betaproteobacteria	F	phosphoribosylaminoimidazolesuccinocarboxamide synthase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_858677_2	399795.CtesDRAFT_PD5311	2.98e-55	179.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2VQ1I@28216|Betaproteobacteria,4ADQH@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_368957_1	1322246.BN4_11498	1.12e-68	227.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIWK@28221|Deltaproteobacteria,2M8CW@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05559,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_140875_1	105559.Nwat_0461	4.75e-23	95.5	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales	135613|Chromatiales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_336616_1	1123393.KB891326_gene77	2.05e-98	312.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria,1KSG6@119069|Hydrogenophilales	119069|Hydrogenophilales	O	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_10470_1	1144325.PMI22_00607	3.95e-82	257.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_108235_2	485913.Krac_10569	6.75e-32	115.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_75860_1	945713.IALB_2402	1.17e-98	308.0	COG0465@1|root,COG0465@2|Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_173524_1	1126627.BAWE01000004_gene3469	1.03e-49	166.0	COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,2TU06@28211|Alphaproteobacteria,3JTAZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nitrate reductase delta subunit	torD	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del,YdaS_antitoxin
k59_205885_1	931627.MycrhDRAFT_4677	2.71e-64	211.0	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria,236EE@1762|Mycobacteriaceae	201174|Actinobacteria	P	transport of arsenical compounds across the membrane (export) arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane	arsA	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
k59_759226_1	644966.Tmar_1670	1.25e-54	187.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,3WCDU@538999|Clostridiales incertae sedis	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_529161_1	1150626.PHAMO_380033	6.61e-87	260.0	COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,2U0Y8@28211|Alphaproteobacteria,2JVFX@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_434178_1	1288494.EBAPG3_22130	1.2e-47	167.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,372E7@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Sigma-54 interaction domain	yfhA	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_663513_1	945713.IALB_1918	7.84e-49	179.0	COG4797@1|root,COG4797@2|Bacteria	2|Bacteria	-	-	sprA	-	-	-	-	-	-	-	-	-	-	-	SprA_N
k59_957207_2	397287.C807_03298	1.91e-07	53.5	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,27K3W@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
k59_108259_1	864051.BurJ1DRAFT_0780	3.95e-106	339.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,1KJC4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
k59_205897_1	243160.BMAA0680	1.31e-55	196.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2VMGW@28216|Betaproteobacteria,1K1FS@119060|Burkholderiaceae	28216|Betaproteobacteria	M	penicillin-binding protein	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
k59_759232_1	1297569.MESS2_1560004	3.26e-37	143.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2TSS7@28211|Alphaproteobacteria,43GTD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Osmosensitive K channel histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
k59_565530_1	365046.Rta_25740	4.27e-17	80.9	COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,2VH3D@28216|Betaproteobacteria,4AAFR@80864|Comamonadaceae	28216|Betaproteobacteria	S	SMART transcription factor jumonji jmjC	ycfD	-	1.14.11.47	ko:K18850	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Cupin_4
k59_565530_2	1175306.GWL_00240	9.16e-28	105.0	COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,2VMTP@28216|Betaproteobacteria,478FY@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_597945_1	247490.KSU1_B0100	3.59e-85	264.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_400285_1	1123228.AUIH01000022_gene3126	0.000102	44.3	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XIUV@135619|Oceanospirillales	135619|Oceanospirillales	NT	chemotaxis protein	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_400285_2	379731.PST_3948	1.65e-34	134.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1Z18Z@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	COG0643 Chemotaxis protein histidine kinase and related kinases	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_303363_1	1336233.JAEH01000004_gene1497	3.37e-29	112.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,2QAF6@267890|Shewanellaceae	1236|Gammaproteobacteria	Q	PFAM ABC transporter related	mlaF	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_303363_2	557598.LHK_01060	1.84e-15	74.7	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,2KQEA@206351|Neisseriales	206351|Neisseriales	Q	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_565535_1	1116472.MGMO_104c00070	3.01e-62	199.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1RNRG@1236|Gammaproteobacteria	1224|Proteobacteria	M	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_42862_2	316067.Geob_1073	3.99e-24	95.5	COG2165@1|root,COG2165@2|Bacteria,1QYWM@1224|Proteobacteria	1224|Proteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_858718_1	1121939.L861_22655	1.89e-54	185.0	COG1173@1|root,COG1173@2|Bacteria,1R4K8@1224|Proteobacteria,1SYV4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EP	Pfam Binding-protein-dependent transport	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_368998_1	511062.GU3_06765	1.11e-18	88.6	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1Y3X8@135624|Aeromonadales	135624|Aeromonadales	M	Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_271378_2	640510.BC1001_2471	5.97e-54	177.0	COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,2VQ1M@28216|Betaproteobacteria,1K5H5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Serine hydrolase	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
k59_108271_1	1007105.PT7_2551	2.03e-102	309.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,3T26Y@506|Alcaligenaceae	28216|Betaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_75895_1	566466.NOR53_3527	1.09e-104	312.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1J5CG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_237000_1	1298867.AUES01000051_gene4511	1.96e-19	94.4	COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
k59_140921_1	269799.Gmet_3341	2.91e-113	336.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,43VCE@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_826814_2	1121403.AUCV01000113_gene4728	1.27e-46	166.0	COG3464@1|root,COG3464@2|Bacteria,1N5CJ@1224|Proteobacteria,43CJ2@68525|delta/epsilon subdivisions,2X7TC@28221|Deltaproteobacteria,2MPPB@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_465428_1	1168034.FH5T_13120	7.77e-39	139.0	COG2197@1|root,COG2197@2|Bacteria,4NKAD@976|Bacteroidetes,2FSDF@200643|Bacteroidia	976|Bacteroidetes	KT	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_75900_1	1485544.JQKP01000002_gene1516	1.37e-100	306.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,44VMS@713636|Nitrosomonadales	28216|Betaproteobacteria	I	PFAM Carbamoyl-phosphate synthase L chain ATP-binding	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_500350_1	706587.Desti_4777	1.1e-24	109.0	COG0471@1|root,COG1055@1|root,COG0471@2|Bacteria,COG1055@2|Bacteria,1N58G@1224|Proteobacteria	1224|Proteobacteria	P	Symporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_sulph_symp
k59_108284_1	987059.RBXJA2T_19641	7.83e-11	62.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,1KJSK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	ilvG	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_696298_1	1463854.JOHT01000001_gene2724	6.67e-09	63.2	COG0308@1|root,COG0308@2|Bacteria,2GJWF@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_237011_1	1123242.JH636435_gene796	4.85e-54	187.0	COG0477@1|root,COG0477@2|Bacteria,2J4Z6@203682|Planctomycetes	203682|Planctomycetes	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_310633_1	1120953.AUBH01000008_gene277	7.94e-95	286.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RPMI@1236|Gammaproteobacteria,466BS@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_148936_1	158500.BV97_05755	3.93e-173	497.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_508308_1	85643.Tmz1t_3073	6.38e-45	158.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria,2KV5D@206389|Rhodocyclales	206389|Rhodocyclales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_508308_2	757424.Hsero_3300	7.89e-06	49.3	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,473WB@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Zn-dependent protease with chaperone function	-	-	-	ko:K07387	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M48
k59_509355_1	314345.SPV1_05994	2.34e-67	216.0	COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria	1224|Proteobacteria	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_997987_1	596154.Alide2_3908	8.91e-82	259.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria,4AHFT@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c oxidase, subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_899309_2	1278073.MYSTI_06360	1.61e-12	67.8	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,42S1V@68525|delta/epsilon subdivisions,2WNDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_182404_1	1219375.CM002139_gene1557	1.9e-57	199.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1X35C@135614|Xanthomonadales	135614|Xanthomonadales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_442822_9	43179.ENSSTOP00000020106	1.54e-09	59.7	COG1231@1|root,KOG0029@2759|Eukaryota,38F1Z@33154|Opisthokonta,3B9CJ@33208|Metazoa,3D0AM@33213|Bilateria,486I4@7711|Chordata,49873@7742|Vertebrata,3JBQY@40674|Mammalia,35APF@314146|Euarchontoglires,4Q1BN@9989|Rodentia	33208|Metazoa	Q	Flavin containing amine oxidoreductase	il4i1	-	1.4.3.2	ko:K03334	ko00250,ko00270,ko00280,ko00350,ko00360,ko00380,ko00400,ko00950,ko01100,map00250,map00270,map00280,map00350,map00360,map00380,map00400,map00950,map01100	M00044	R00357,R00648,R00677,R00689,R00729,R02197	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_117288_1	748658.KB907314_gene104	4.74e-31	116.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1WXZW@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_2
k59_117288_2	314278.NB231_15718	1e-33	119.0	COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria	1224|Proteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_966464_1	1236541.BALL01000017_gene2349	4.68e-32	125.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,2QB9P@267890|Shewanellaceae	1236|Gammaproteobacteria	J	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,RhlB
k59_867564_1	886293.Sinac_4145	1.1e-13	73.2	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_8,WD40
k59_997988_1	1121405.dsmv_0444	7.01e-85	259.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2MJIB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_867565_1	666681.M301_0028	1.37e-61	211.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,2KM2V@206350|Nitrosomonadales	206350|Nitrosomonadales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_966467_1	296591.Bpro_3358	7.24e-58	196.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,4AARI@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_442827_2	760568.Desku_0058	8.01e-44	152.0	COG1962@1|root,COG1962@2|Bacteria,1UYYD@1239|Firmicutes,24AC2@186801|Clostridia,26150@186807|Peptococcaceae	186801|Clostridia	H	Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
k59_509366_1	1265310.CCBD010000050_gene1878	0.000436	43.5	COG1028@1|root,COG2072@1|root,COG1028@2|Bacteria,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,233PF@1762|Mycobacteriaceae	201174|Actinobacteria	P	Flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like,K_oxygenase,Pyr_redox_3
k59_509366_2	1366050.N234_09365	1.35e-13	74.3	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VP9X@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_997994_1	1231391.AMZF01000094_gene118	4.15e-48	170.0	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_867571_2	1122201.AUAZ01000043_gene1288	5.55e-52	167.0	COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,1S4I5@1236|Gammaproteobacteria,46DMQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
k59_509370_1	595537.Varpa_3612	6.25e-76	243.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,4AB8V@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit	fdwB	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_276003_2	1163617.SCD_n00382	4.13e-17	82.8	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VK35@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	soxF	-	1.8.2.3,1.8.5.4	ko:K17218,ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499,R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DUF442,FCSD-flav_bind,Pyr_redox_2
k59_345550_1	330214.NIDE0861	3.84e-74	243.0	COG1657@1|root,COG1657@2|Bacteria,3J0ZD@40117|Nitrospirae	40117|Nitrospirae	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
k59_311619_1	748247.AZKH_p0369	1.29e-69	223.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2VJHA@28216|Betaproteobacteria,2KWAS@206389|Rhodocyclales	28216|Betaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_472870_1	626418.bglu_1g26690	9.24e-32	117.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2VIRB@28216|Betaproteobacteria,1K260@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_472870_2	1502770.JQMG01000001_gene409	6.27e-81	247.0	COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,2VNWT@28216|Betaproteobacteria,2KNJX@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_639238_1	867845.KI911784_gene835	1.19e-60	197.0	COG2120@1|root,COG2120@2|Bacteria,2G6W3@200795|Chloroflexi,375I3@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_407776_1	1121861.KB899919_gene2755	1.62e-65	206.0	COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2TSQT@28211|Alphaproteobacteria,2JRFA@204441|Rhodospirillales	204441|Rhodospirillales	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
k59_407776_3	1254432.SCE1572_48085	8.02e-76	242.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria	1224|Proteobacteria	H	biosynthesis protein E	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_311622_1	999419.HMPREF1077_00292	8.15e-84	266.0	COG0018@1|root,COG0018@2|Bacteria,4NE7Q@976|Bacteroidetes,2FN06@200643|Bacteroidia,22VUX@171551|Porphyromonadaceae	976|Bacteroidetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_244501_1	690850.Desaf_0721	2.25e-64	219.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2M800@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Pyruvate phosphate dikinase, PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_574668_1	1122604.JONR01000006_gene2711	8.46e-68	216.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,1X33N@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_899337_1	1112216.JH594425_gene222	8.36e-34	133.0	COG3661@1|root,COG3661@2|Bacteria,1MXKA@1224|Proteobacteria,2U0WK@28211|Alphaproteobacteria,2JZXC@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the glycosyl hydrolase 67 family	-	-	3.2.1.139	ko:K01235	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N
k59_533619_1	519989.ECTPHS_01174	3.39e-56	196.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_790241_1	234267.Acid_5940	3.35e-67	228.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_345563_1	1121351.AUAP01000019_gene1075	5.43e-07	48.9	COG2906@1|root,COG2906@2|Bacteria,1NCYC@1224|Proteobacteria,2VVXY@28216|Betaproteobacteria	28216|Betaproteobacteria	P	2Fe-2S -binding domain protein	-	-	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
k59_345563_2	1116472.MGMO_18c00210	5.07e-44	146.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,1S45S@1236|Gammaproteobacteria,1XF2W@135618|Methylococcales	135618|Methylococcales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_738079_1	504472.Slin_2663	1.26e-40	138.0	COG2963@1|root,COG2963@2|Bacteria,4NQ94@976|Bacteroidetes,47T18@768503|Cytophagia	976|Bacteroidetes	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_738079_2	247634.GPB2148_14	4.09e-140	406.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
k59_606885_2	1232410.KI421422_gene1939	6.01e-09	57.8	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,43TME@69541|Desulfuromonadales	28221|Deltaproteobacteria	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat
k59_51708_1	330214.NIDE1687	2.43e-36	141.0	COG0841@1|root,COG0841@2|Bacteria,3J103@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_345570_1	748247.AZKH_3545	1.25e-36	134.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria,2KVXA@206389|Rhodocyclales	206389|Rhodocyclales	S	cytochrome d1 heme	nirF	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
k59_345570_2	85643.Tmz1t_2612	1.1e-51	175.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,2VHP8@28216|Betaproteobacteria,2KUR4@206389|Rhodocyclales	206389|Rhodocyclales	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_867603_1	1173263.Syn7502_00288	1.8e-19	92.4	COG0745@1|root,COG2199@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1H4EV@1129|Synechococcus	1117|Cyanobacteria	KT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_2,PAS_3,PAS_4,PAS_9,PHY,Response_reg,dCache_1
k59_345572_1	1005048.CFU_3136	2.18e-76	241.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,472KW@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aminotransferase class I and II	tyrB	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_472893_1	177439.DP2536	1.89e-57	200.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MJ5T@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_836197_1	1232410.KI421413_gene926	1.73e-73	244.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,43S3P@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Valyl tRNA synthetase tRNA binding arm	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_966516_1	1100721.ALKO01000015_gene1053	7.76e-61	199.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,4AB8M@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_705663_2	1288494.EBAPG3_22130	4.16e-101	310.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,372E7@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Sigma-54 interaction domain	yfhA	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_766851_2	1304883.KI912532_gene921	3.33e-78	239.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2VHBM@28216|Betaproteobacteria,2KUUC@206389|Rhodocyclales	206389|Rhodocyclales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_407802_1	765911.Thivi_4511	1.67e-51	176.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1WWWX@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_442873_1	945713.IALB_2950	1.12e-71	224.0	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_377610_1	234267.Acid_4206	9.69e-43	158.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_276026_2	1128421.JAGA01000002_gene949	2.79e-13	66.2	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	mltA	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_51724_1	1454004.AW11_00495	2.14e-94	285.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2VH6H@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Glucose sorbosone	yliI	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
k59_836213_2	330214.NIDE3966	1.12e-81	255.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cvaA	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,OEP
k59_867625_1	1499967.BAYZ01000185_gene4537	2.14e-66	213.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_244536_1	864051.BurJ1DRAFT_2886	3.49e-151	436.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,1KN36@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_244536_2	1288494.EBAPG3_3040	2.71e-73	236.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,371N8@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_509432_1	886293.Sinac_4963	1.09e-108	326.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_738123_1	1123368.AUIS01000001_gene2023	1.61e-84	270.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,2NCS6@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_639296_2	292415.Tbd_2731	1.02e-50	169.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2VHEW@28216|Betaproteobacteria,1KSPF@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_345604_1	946483.Cenrod_1715	2.08e-24	107.0	COG1729@1|root,COG5617@1|root,COG1729@2|Bacteria,COG5617@2|Bacteria,1RBCY@1224|Proteobacteria	1224|Proteobacteria	S	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related
k59_574720_1	713586.KB900536_gene2263	4.99e-31	114.0	COG3439@1|root,COG3439@2|Bacteria,1N3NF@1224|Proteobacteria,1ST0K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_836229_1	522306.CAP2UW1_1261	2.89e-75	249.0	COG5164@1|root,COG5164@2|Bacteria,1MX1Z@1224|Proteobacteria,2VKEC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_59327_1	880073.Calab_1713	5.93e-76	241.0	COG1660@1|root,COG3178@1|root,COG1660@2|Bacteria,COG3178@2|Bacteria,2NP9G@2323|unclassified Bacteria	2|Bacteria	S	P-loop ATPase protein family	-	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.1.221	ko:K06958,ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000,ko03019	-	-	-	APH,ATP_bind_2
k59_517654_1	1232410.KI421424_gene1744	5.27e-54	180.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_746405_2	1415780.JPOG01000001_gene2297	1.59e-17	81.3	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,1S92R@1236|Gammaproteobacteria,1XC0I@135614|Xanthomonadales	135614|Xanthomonadales	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_583034_1	583355.Caka_2609	7.67e-44	162.0	COG1283@1|root,COG1283@2|Bacteria,46XC7@74201|Verrucomicrobia,3K8B5@414999|Opitutae	414999|Opitutae	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_318852_1	392499.Swit_3634	8.62e-88	265.0	COG1028@1|root,COG1028@2|Bacteria,1PGYV@1224|Proteobacteria,2VEVG@28211|Alphaproteobacteria,2K2ZW@204457|Sphingomonadales	204457|Sphingomonadales	IQ	short-chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_479623_1	1459636.NTE_00018	8.35e-102	304.0	COG0115@1|root,arCOG02297@2157|Archaea,41SD5@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_450639_1	1163730.FFONT_0299	8.03e-23	100.0	COG0517@1|root,arCOG00600@2157|Archaea,2XQMG@28889|Crenarchaeota	28889|Crenarchaeota	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_93336_1	580332.Slit_1860	1.15e-72	226.0	COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,2VM6G@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K13775	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short
k59_746410_1	426355.Mrad2831_2790	9.29e-06	46.6	COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria,2U0GD@28211|Alphaproteobacteria,1JSQ7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	PFAM formyl transferase domain protein	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_746410_2	744985.HIMB59_00013810	4.35e-29	116.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4BPJW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1005772_1	1238182.C882_2237	5.59e-51	169.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,2JS96@204441|Rhodospirillales	204441|Rhodospirillales	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1005772_2	998088.B565_2996	2.24e-10	60.8	COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1Y531@135624|Aeromonadales	135624|Aeromonadales	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_125305_1	696747.NIES39_J00220	0.000273	45.1	COG1357@1|root,COG1357@2|Bacteria,1G37B@1117|Cyanobacteria,1HAA6@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
k59_583052_1	94624.Bpet3438	3.11e-69	223.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,3T60T@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_353550_1	1265502.KB905935_gene3052	5.97e-77	232.0	COG2236@1|root,COG2236@2|Bacteria,1R675@1224|Proteobacteria,2VPZG@28216|Betaproteobacteria,4AA1G@80864|Comamonadaceae	28216|Betaproteobacteria	F	PFAM Phosphoribosyltransferase	gpt	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
k59_875504_1	316067.Geob_3590	3.96e-105	318.0	COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,43TAK@69541|Desulfuromonadales	28221|Deltaproteobacteria	A	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_125322_1	1121033.AUCF01000006_gene4206	3.71e-12	65.9	COG0517@1|root,COG2823@1|root,COG0517@2|Bacteria,COG2823@2|Bacteria,1NY5H@1224|Proteobacteria,2U1GG@28211|Alphaproteobacteria,2JX0D@204441|Rhodospirillales	204441|Rhodospirillales	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
k59_125322_2	909943.HIMB100_00009530	5.51e-45	148.0	2E5W4@1|root,330K6@2|Bacteria,1PJII@1224|Proteobacteria,2VDW5@28211|Alphaproteobacteria,4BSQK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
k59_746437_1	338966.Ppro_0188	2.52e-56	191.0	COG3385@1|root,COG3385@2|Bacteria,1R8CS@1224|Proteobacteria,42P9F@68525|delta/epsilon subdivisions,2WKTA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_2
k59_190057_1	1123400.KB904755_gene2632	1.05e-29	112.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,460MZ@72273|Thiotrichales	72273|Thiotrichales	T	PFAM Response regulator receiver domain	-	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_190057_2	1123399.AQVE01000001_gene677	1.73e-28	115.0	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,1RPG9@1236|Gammaproteobacteria,460R7@72273|Thiotrichales	72273|Thiotrichales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_93365_1	62928.azo1676	2.34e-83	257.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2VINV@28216|Betaproteobacteria,2KU6E@206389|Rhodocyclales	206389|Rhodocyclales	C	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_844626_1	404589.Anae109_1775	8.89e-55	192.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,42ZD0@68525|delta/epsilon subdivisions,2WU4P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_713967_1	582899.Hden_1668	1.37e-100	303.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,3N83R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_251463_1	335543.Sfum_2285	8.32e-159	454.0	COG0683@1|root,COG0683@2|Bacteria,1RFC0@1224|Proteobacteria,42YW4@68525|delta/epsilon subdivisions,2WTXP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_517693_1	1408226.T233_01595	1.25e-45	166.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,4HA6S@91061|Bacilli,4AZX0@81852|Enterococcaceae	91061|Bacilli	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_681235_2	1198232.CYCME_1780	4.29e-15	71.2	2EAIM@1|root,334MN@2|Bacteria,1N6XM@1224|Proteobacteria,1SF6C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_681235_3	331869.BAL199_24829	1.78e-56	191.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,4BPJI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	nuoL2	-	1.6.5.3	ko:K00341,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_157986_1	1121405.dsmv_3476	1.67e-107	334.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MJ6A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_251464_1	375286.mma_3075	2.41e-40	147.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2W9AN@28216|Betaproteobacteria,477ZK@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.2.2	ko:K01781	ko00627,ko01120,map00627,map01120	-	R03791,R04161	RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_450676_1	1343740.M271_18345	2e-26	106.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_942209_2	926569.ANT_22920	5.95e-50	159.0	COG0759@1|root,COG0759@2|Bacteria,2G76Q@200795|Chloroflexi	200795|Chloroflexi	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
k59_27720_2	641491.DND132_2968	2.2e-06	48.1	COG3462@1|root,COG3462@2|Bacteria,1QE33@1224|Proteobacteria,43EKD@68525|delta/epsilon subdivisions,2X0Z4@28221|Deltaproteobacteria,2MDTR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
k59_318906_1	428125.CLOLEP_02119	4.4e-18	87.8	COG4409@1|root,COG4409@2|Bacteria,1V5Q1@1239|Firmicutes,24FGZ@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43
k59_1005822_2	383372.Rcas_0545	2.6e-21	95.5	COG1022@1|root,COG1022@2|Bacteria,2G5S9@200795|Chloroflexi,37561@32061|Chloroflexia	32061|Chloroflexia	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_746475_1	1504672.669784146	1.75e-30	114.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,4AANW@80864|Comamonadaceae	28216|Betaproteobacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_746475_2	640081.Dsui_1190	1e-11	64.3	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,2VSVR@28216|Betaproteobacteria,2KWK4@206389|Rhodocyclales	206389|Rhodocyclales	NU	pilus assembly protein PilP	pilP	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_537695_1	492774.JQMB01000006_gene6504	2.14e-15	77.8	COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria,4B8UW@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
k59_907124_1	265072.Mfla_2758	2.07e-26	107.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,2KM2S@206350|Nitrosomonadales	206350|Nitrosomonadales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_907124_2	1235457.C404_22945	1.48e-36	136.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2VHCJ@28216|Betaproteobacteria,1JZXE@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_774054_1	1207058.L53_09205	3.19e-17	81.6	COG0004@1|root,COG1496@1|root,COG0004@2|Bacteria,COG1496@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,43WQ0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_774054_2	521719.ATXQ01000011_gene96	2.65e-42	140.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1YG2H@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	nitrogen regulatory protein P-II	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_614929_1	330214.NIDE1349	4.91e-73	224.0	COG3166@1|root,COG3166@2|Bacteria,3J1EX@40117|Nitrospirae	40117|Nitrospirae	NU	Fimbrial assembly protein (PilN)	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_614929_2	330214.NIDE1350	7.95e-49	162.0	COG3167@1|root,COG3167@2|Bacteria,3J1BH@40117|Nitrospirae	40117|Nitrospirae	NU	Pilus assembly protein, PilO	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_774060_1	93220.LV28_20200	1.24e-05	43.5	COG5487@1|root,COG5487@2|Bacteria,1NGAH@1224|Proteobacteria,2VW3H@28216|Betaproteobacteria,1KHE5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	UPF0391 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
k59_479689_2	596152.DesU5LDRAFT_0045	2.09e-07	52.4	COG1028@1|root,COG1028@2|Bacteria,1MUAY@1224|Proteobacteria,42NIM@68525|delta/epsilon subdivisions,2WMK8@28221|Deltaproteobacteria,2MBBR@213115|Desulfovibrionales	28221|Deltaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_583125_2	406552.NJ7G_2116	2.64e-29	114.0	COG1653@1|root,arCOG00151@2157|Archaea,2Y2AY@28890|Euryarchaeota,23Z4Y@183963|Halobacteria	183963|Halobacteria	G	COG1653 ABC-type sugar transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_793526_1	1232410.KI421427_gene1264	5.71e-82	258.0	COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,42R72@68525|delta/epsilon subdivisions,2WMSM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_793526_2	1125863.JAFN01000001_gene3567	1.27e-07	51.6	COG2755@1|root,COG2755@2|Bacteria,1RHDZ@1224|Proteobacteria,42SMX@68525|delta/epsilon subdivisions	1224|Proteobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	3.1.2.20	ko:K01073	-	-	-	-	ko00000,ko01000	-	-	-	Lipase_GDSL_2
k59_125392_2	795666.MW7_0317	3.4e-68	220.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,1K2B7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
k59_450729_1	1026882.MAMP_01644	2.01e-77	244.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,4606R@72273|Thiotrichales	72273|Thiotrichales	L	ATPase (AAA	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_125395_1	640511.BC1002_1248	7.31e-61	206.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,1K4J9@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_774073_1	864051.BurJ1DRAFT_3329	4.46e-62	204.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,2VJGA@28216|Betaproteobacteria,1KN5P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Fe-S oxidoreductase	-	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_774073_2	864051.BurJ1DRAFT_3330	7.77e-119	345.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,2VPFB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
k59_614956_1	648757.Rvan_3026	0.000249	50.4	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,3N655@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
k59_125397_1	1288494.EBAPG3_10500	2.08e-81	253.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,3723U@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_280290_1	1231190.NA8A_02385	5.01e-72	227.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,43HSV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	PFAM Class II Aldolase and Adducin N-terminal domain	MA20_30505	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_1005874_1	1229909.NSED_02835	5.23e-93	276.0	COG0580@1|root,arCOG04431@2157|Archaea,41S5R@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Major Intrinsic Protein	-	-	-	ko:K06188,ko:K09866	ko04962,ko04976,map04962,map04976	-	-	-	ko00000,ko00001,ko02000	1.A.8	-	-	MIP
k59_907164_2	497964.CfE428DRAFT_3555	6.09e-57	184.0	COG0288@1|root,COG0288@2|Bacteria,46S9J@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_714049_1	330214.NIDE4113	2.23e-114	337.0	COG0498@1|root,COG0498@2|Bacteria,3J0FI@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC2	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_517784_1	1348657.M622_14640	2.66e-83	261.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,2KV7J@206389|Rhodocyclales	206389|Rhodocyclales	C	glycolate oxidase subunit GlcD	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_190137_1	883.DvMF_1515	3.45e-70	237.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_93455_1	1121405.dsmv_0498	6.86e-40	145.0	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,42NU5@68525|delta/epsilon subdivisions,2WJV4@28221|Deltaproteobacteria,2MJDU@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_414853_1	335543.Sfum_3755	1.48e-66	218.0	COG5421@1|root,COG5421@2|Bacteria,1Q09R@1224|Proteobacteria,437PJ@68525|delta/epsilon subdivisions,2WYMZ@28221|Deltaproteobacteria,2MRCG@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_385180_1	883080.HMPREF9697_03066	6.12e-58	191.0	COG1893@1|root,COG1893@2|Bacteria,1QMH8@1224|Proteobacteria,2TSGW@28211|Alphaproteobacteria,3JWCH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_942287_2	933262.AXAM01000019_gene1130	1.52e-40	141.0	COG1648@1|root,COG1648@2|Bacteria,1RB3H@1224|Proteobacteria,42QT2@68525|delta/epsilon subdivisions,2WN1F@28221|Deltaproteobacteria,2MJPS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
k59_746539_1	1502851.FG93_03435	4.03e-86	258.0	COG3631@1|root,COG3631@2|Bacteria,1RGEA@1224|Proteobacteria,2U7YB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
k59_125419_1	1499967.BAYZ01000009_gene5394	2.82e-96	299.0	COG2766@1|root,COG2766@2|Bacteria	2|Bacteria	T	protein kinase activity	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_353668_1	1515746.HR45_18380	4.57e-12	65.9	COG2207@1|root,COG2207@2|Bacteria,1Q4N1@1224|Proteobacteria,1S07G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,HTH_18,HTH_AraC
k59_747294_1	1038869.AXAN01000022_gene1935	2.38e-117	355.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,1K4WQ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PhaC_N
k59_319625_1	1538295.JY96_04815	2.52e-62	205.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,1KK68@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_60182_1	1121405.dsmv_2717	5.31e-58	201.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_480414_2	13035.Dacsa_1190	3.26e-20	94.4	COG1994@1|root,COG1994@2|Bacteria,1G03A@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_747302_1	1430440.MGMSRv2_0747	4.87e-07	50.8	COG2885@1|root,COG2885@2|Bacteria,1MZKA@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_802087_1	1288494.EBAPG3_7390	8.41e-90	274.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,372NZ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_802089_1	1048339.KB913029_gene3110	5.08e-40	151.0	28IIF@1|root,2Z8JJ@2|Bacteria,2H9N3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_289821_1	641491.DND132_0695	4.89e-56	189.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria,2MEFN@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	cbcP	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_N_2,Cytochrome_B
k59_289829_1	1288494.EBAPG3_2720	4.7e-73	243.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,372B8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_802161_1	85643.Tmz1t_2208	6.71e-47	159.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,2KVCE@206389|Rhodocyclales	206389|Rhodocyclales	E	serine acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
k59_1034094_1	1229909.NSED_06945	9.77e-110	322.0	COG0379@1|root,arCOG04459@2157|Archaea,41S6Y@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_1034094_2	436308.Nmar_1240	2.64e-22	92.4	COG1712@1|root,arCOG00254@2157|Archaea,41SGA@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
k59_289875_1	1229909.NSED_07505	2.79e-25	100.0	COG1409@1|root,arCOG01153@2157|Archaea,41SF2@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_289878_1	76114.ebA3896	2.04e-16	77.0	COG1711@1|root,COG1711@2|Bacteria,1RIA0@1224|Proteobacteria,2VIHJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3014)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3014
k59_1034108_1	1121127.JAFA01000007_gene5236	1.26e-91	279.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1K2TY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_289896_1	1121904.ARBP01000005_gene4553	5.66e-63	214.0	COG3378@1|root,COG3378@2|Bacteria,4NE1A@976|Bacteroidetes,47TNG@768503|Cytophagia	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1034116_1	1229909.NSED_00395	4.15e-159	457.0	COG0843@1|root,arCOG01237@2157|Archaea,41S9Z@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Heme copper-type cytochrome quinol	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_802239_1	1267005.KB911257_gene867	3.17e-69	227.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,3N690@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	TrkA-C domain	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_802249_1	688246.Premu_2262	5.46e-07	57.0	COG1300@1|root,COG1300@2|Bacteria,4NG8D@976|Bacteroidetes,2FMWM@200643|Bacteroidia	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
k59_1034167_2	4792.ETI53427	4.13e-56	191.0	COG4799@1|root,KOG0540@2759|Eukaryota,3QBV3@4776|Peronosporales	4776|Peronosporales	EI	Carboxyl transferase domain	-	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_289995_1	525909.Afer_1765	6.17e-75	237.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4CMTB@84992|Acidimicrobiia	84992|Acidimicrobiia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_802314_2	98439.AJLL01000089_gene3829	1.56e-143	425.0	COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria,1JHRW@1189|Stigonemataceae	1117|Cyanobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_802314_3	522306.CAP2UW1_3650	5.35e-137	402.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPV5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_290011_1	1538295.JY96_20205	2.66e-61	208.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJ7X@28216|Betaproteobacteria,1KJBC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtB	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_290019_1	598467.BrE312_1893	1.63e-10	61.6	2DS6K@1|root,33ESK@2|Bacteria,1NHA4@1224|Proteobacteria,1SDWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_549391_1	926569.ANT_04990	1.64e-32	117.0	COG1662@1|root,COG1662@2|Bacteria	2|Bacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
k59_802375_2	267608.RSc1611	3.35e-63	200.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VNV2@28216|Betaproteobacteria,1K0C9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_1034273_1	1266925.JHVX01000013_gene1644	8.86e-51	167.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,3720V@32003|Nitrosomonadales	28216|Betaproteobacteria	H	UBA THIF-type NAD FAD binding	thiF	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_1034273_2	42256.RradSPS_1354	2.12e-39	145.0	COG3509@1|root,COG3509@2|Bacteria,2HENW@201174|Actinobacteria,4CR4Z@84995|Rubrobacteria	84995|Rubrobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
k59_549434_1	224911.27351364	6.26e-42	156.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_802423_1	765912.Thimo_2787	3.53e-82	257.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_549457_1	1288494.EBAPG3_8330	3.49e-100	317.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,371SX@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Aconitase C-terminal domain	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_549509_2	759914.BP951000_1678	1.05e-07	51.6	COG1872@1|root,COG1872@2|Bacteria	2|Bacteria	I	DUF167	CP_0257	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_549509_3	1485544.JQKP01000002_gene1637	4.7e-14	71.2	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,2VRHV@28216|Betaproteobacteria,44VT3@713636|Nitrosomonadales	28216|Betaproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_1034343_1	1266925.JHVX01000003_gene413	1.47e-97	301.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2VH1G@28216|Betaproteobacteria,37202@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_802524_1	1005048.CFU_3531	1.14e-123	366.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2VH7T@28216|Betaproteobacteria,4738R@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	MmgE/PrpD family	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
k59_549535_1	29581.BW37_04160	2.26e-95	293.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,4730R@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Belongs to the malate synthase family	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_290202_1	1278073.MYSTI_07226	2.38e-49	174.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42QS7@68525|delta/epsilon subdivisions,2X74U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_802584_1	330214.NIDE4347	5.96e-171	488.0	COG0065@1|root,COG0065@2|Bacteria,3J0IH@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_549607_1	106370.Francci3_1034	9.76e-43	158.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4ES40@85013|Frankiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_549620_1	329726.AM1_0220	5.23e-31	126.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF,GAF_3,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1034439_1	555779.Dthio_PD0371	6.71e-135	396.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria,2M8B8@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_1034455_1	987059.RBXJA2T_16877	2.08e-41	144.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,1KJR2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1034455_2	987059.RBXJA2T_16882	1.07e-41	138.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,1KMBR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_1034463_1	1461580.CCAS010000005_gene794	2.6e-62	197.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,1ZBWK@1386|Bacillus	91061|Bacilli	P	radicals which are normally produced within the cells and which are toxic to biological systems	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_290320_1	1207063.P24_03031	1.52e-93	283.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,2JQBK@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_290320_2	261292.Nit79A3_0774	2.43e-45	155.0	COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2WGMS@28216|Betaproteobacteria,3721D@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_802708_2	1163617.SCD_n01505	4.5e-102	315.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_549701_1	1131553.JIBI01000021_gene263	1.23e-22	97.1	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,371U0@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_549702_1	1123037.AUDE01000046_gene849	6.54e-95	291.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia	976|Bacteroidetes	Q	Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_549716_1	1380387.JADM01000003_gene2495	1.57e-71	226.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1XHNJ@135619|Oceanospirillales	135619|Oceanospirillales	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_1034511_1	926549.KI421517_gene1519	1.95e-35	138.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,47NT4@768503|Cytophagia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1034514_1	1187851.A33M_2528	1.67e-109	326.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2TRWV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_802747_1	330214.NIDE0052	2.29e-37	134.0	COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Lactamase_B,Lactamase_B_5
k59_802765_1	926569.ANT_01830	7.08e-76	254.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_290463_1	880073.Calab_2073	2.38e-05	52.4	2E09V@1|root,32VXB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_813465_1	1131266.ARWQ01000001_gene1346	7.18e-08	59.7	arCOG08812@1|root,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_813498_1	1288494.EBAPG3_1470	1.67e-50	163.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VR3P@28216|Betaproteobacteria,374M5@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_813498_2	765914.ThisiDRAFT_1399	3.47e-51	175.0	COG0388@1|root,COG1247@1|root,COG0388@2|Bacteria,COG1247@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1WW4Z@135613|Chromatiales	135613|Chromatiales	K	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_813542_1	1415779.JOMH01000001_gene595	1.63e-33	125.0	COG0406@1|root,COG0406@2|Bacteria,1RB0S@1224|Proteobacteria,1S3H1@1236|Gammaproteobacteria,1X6BM@135614|Xanthomonadales	135614|Xanthomonadales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_1043045_1	701176.VIBRN418_11145	8.49e-06	53.1	COG1361@1|root,COG2304@1|root,COG2931@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XSBS@135623|Vibrionales	135623|Vibrionales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VWA
k59_813585_1	1157708.KB907462_gene897	2.93e-85	262.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,4AB2U@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_1043049_1	76114.ebA4050	6.4e-123	355.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VNV2@28216|Betaproteobacteria,2KUPV@206389|Rhodocyclales	206389|Rhodocyclales	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_1043049_2	1502851.FG93_04345	4.68e-80	248.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,2TVRD@28211|Alphaproteobacteria,3K5Z9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
k59_813602_1	754476.Q7A_1644	2.75e-12	70.9	2DM2X@1|root,31HF3@2|Bacteria,1RIYM@1224|Proteobacteria,1SFV4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_813635_1	1499967.BAYZ01000013_gene6469	7.51e-103	315.0	COG1178@1|root,COG1178@2|Bacteria	2|Bacteria	P	thiamine transport	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_813654_1	330214.NIDE1816	4.74e-123	355.0	COG0476@1|root,COG0476@2|Bacteria,3J0X5@40117|Nitrospirae	40117|Nitrospirae	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_813654_2	330214.NIDE1815	9.96e-67	207.0	COG1310@1|root,COG1310@2|Bacteria,3J0U8@40117|Nitrospirae	40117|Nitrospirae	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
k59_1043100_1	395019.Bmul_4181	1.94e-57	198.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,1K0XH@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_813691_1	1268622.AVS7_00586	1.11e-116	353.0	COG0668@1|root,COG0668@2|Bacteria,1MXH4@1224|Proteobacteria,2VM0E@28216|Betaproteobacteria,4AJT7@80864|Comamonadaceae	28216|Betaproteobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_813694_1	713586.KB900536_gene2525	2.65e-152	436.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_813761_1	330214.NIDE1216	2.59e-91	277.0	COG0276@1|root,COG0276@2|Bacteria,3J0P9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_813761_2	330214.NIDE1217	1.25e-41	149.0	COG1232@1|root,COG1232@2|Bacteria,3J0PQ@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1043187_1	330214.NIDE0848	5.2e-94	280.0	COG0755@1|root,COG0755@2|Bacteria,3J0NY@40117|Nitrospirae	40117|Nitrospirae	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_1043187_2	330214.NIDE0849	4.72e-32	117.0	COG0526@1|root,COG0526@2|Bacteria,3J0SG@40117|Nitrospirae	40117|Nitrospirae	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_813812_1	1205680.CAKO01000007_gene4277	6.39e-45	158.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JRXA@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_1043228_1	395494.Galf_0409	1.47e-88	269.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2VIMV@28216|Betaproteobacteria,44V7W@713636|Nitrosomonadales	28216|Betaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_694071_1	426114.THI_0811	4.15e-84	262.0	COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,2VH0A@28216|Betaproteobacteria,1KNEI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Amidohydrolase family	hutF	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_73704_1	713586.KB900536_gene3030	1.92e-60	192.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales	135613|Chromatiales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_73704_2	857087.Metme_3300	2.89e-39	144.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1XDUN@135618|Methylococcales	135618|Methylococcales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_432163_1	717774.Marme_2239	4.88e-81	251.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1XHJ7@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_334543_1	1168034.FH5T_15850	4.29e-58	196.0	COG2730@1|root,COG2730@2|Bacteria,4NH83@976|Bacteroidetes,2FNQD@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_6,Cellulase
k59_955009_1	1278309.KB907100_gene1841	8.3e-56	187.0	COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,1RP58@1236|Gammaproteobacteria,1XIU6@135619|Oceanospirillales	135619|Oceanospirillales	E	Aminotransferase	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_987093_1	639030.JHVA01000001_gene3656	1.14e-11	67.8	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
k59_661399_1	1095769.CAHF01000011_gene2197	1.16e-17	82.8	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,47391@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_694089_1	1509403.GW12_03080	0.000162	45.8	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,3NJMD@468|Moraxellaceae	1236|Gammaproteobacteria	S	LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_694089_2	1163617.SCD_n00009	1.15e-36	128.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_398450_1	1502851.FG93_04653	2.51e-101	303.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,3JXB7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_888910_1	1265502.KB905952_gene796	4.19e-127	381.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,4AB6C@80864|Comamonadaceae	28216|Betaproteobacteria	G	Belongs to the transketolase family	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_106138_2	1454004.AW11_03686	2.11e-11	66.6	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KQAC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	SNARE associated Golgi protein	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_856654_1	987059.RBXJA2T_03698	4.02e-72	234.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2VKR6@28216|Betaproteobacteria,1KIXT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_171400_2	421052.F945_02820	2.55e-44	150.0	COG0720@1|root,COG0720@2|Bacteria,1RKYI@1224|Proteobacteria,1STAI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	-	-	-	-	-	-	-	-	-	-	PTPS
k59_171400_3	490899.DKAM_0478	1.5e-14	75.1	COG2236@1|root,arCOG00040@2157|Archaea,2XQAT@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM phosphoribosyltransferase	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
k59_171400_4	523794.Lebu_0166	9.4e-25	101.0	COG0242@1|root,COG0242@2|Bacteria,37AFU@32066|Fusobacteria	32066|Fusobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_171400_8	238854.Q5GQL9_BPSYP	1.04e-132	406.0	4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses  no RNA stage,4QPYH@28883|Caudovirales,4QIYN@10662|Myoviridae	10662|Myoviridae	S	exonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_628347_1	706587.Desti_1549	2.57e-67	214.0	COG1024@1|root,COG1024@2|Bacteria,1N2V7@1224|Proteobacteria,42UXR@68525|delta/epsilon subdivisions,2WQCT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_922559_1	383372.Rcas_0405	3.84e-65	214.0	COG3385@1|root,COG3385@2|Bacteria,2G8GC@200795|Chloroflexi,3768R@32061|Chloroflexia	32061|Chloroflexia	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_757389_1	1121468.AUBR01000015_gene2268	2.18e-109	329.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,42ESC@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_366944_1	95619.PM1_0210315	3.85e-87	265.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	yadG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_726558_1	96561.Dole_2336	1.66e-54	188.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2MJ5W@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM sulfate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_334553_1	545696.HOLDEFILI_04158	1.8e-53	179.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,3VP56@526524|Erysipelotrichia	526524|Erysipelotrichia	V	Psort location CytoplasmicMembrane, score	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_334553_2	357808.RoseRS_1075	3.47e-90	306.0	COG0577@1|root,COG0577@2|Bacteria,2G68F@200795|Chloroflexi,376ZY@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_40760_1	1288494.EBAPG3_2720	1.44e-109	343.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,372B8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_563396_1	156889.Mmc1_3118	6.78e-70	213.0	arCOG06471@1|root,32BPX@2|Bacteria,1N0MJ@1224|Proteobacteria,2UNJQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MTH538 TIR-like domain (DUF1863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863
k59_563396_2	572546.Arcpr_1769	1.69e-07	51.2	arCOG13036@1|root,arCOG13036@2157|Archaea,2Y25M@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_922565_1	1156919.QWC_17557	4.9e-24	101.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,3T6AH@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_922565_2	1380386.JIAW01000030_gene3579	8.08e-44	156.0	COG0715@1|root,COG0715@2|Bacteria,2HZMX@201174|Actinobacteria,239KD@1762|Mycobacteriaceae	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
k59_138853_1	1288494.EBAPG3_26360	1.35e-109	336.0	COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria,3722N@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_40764_1	1437824.BN940_09831	2.14e-85	276.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,3T2IP@506|Alcaligenaceae	28216|Betaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_106157_1	1485544.JQKP01000002_gene1397	5.33e-48	166.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,44V36@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_106157_2	292415.Tbd_2701	7.23e-53	174.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,1KRK0@119069|Hydrogenophilales	119069|Hydrogenophilales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_73750_1	330214.NIDE4238	9.17e-137	410.0	COG0495@1|root,COG0495@2|Bacteria,3J0F8@40117|Nitrospirae	40117|Nitrospirae	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
k59_432198_1	1454004.AW11_02853	2.33e-30	110.0	COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria	1224|Proteobacteria	P	COG1006 Multisubunit Na H antiporter, MnhC subunit	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_432198_2	1122134.KB893651_gene2097	9.16e-05	45.8	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1XHVS@135619|Oceanospirillales	135619|Oceanospirillales	CP	COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_40770_1	28072.Nos7524_3266	9.32e-37	136.0	COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,1HJR6@1161|Nostocales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_235213_2	748280.NH8B_1171	2.9e-51	163.0	COG3813@1|root,COG3813@2|Bacteria,1N712@1224|Proteobacteria,2VUHC@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1272)	-	-	-	ko:K09984	-	-	-	-	ko00000	-	-	-	DUF1272
k59_628366_1	977880.RALTA_A1397	1.35e-67	217.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_628366_2	391038.Bphy_3687	5.95e-38	134.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VJQ0@28216|Betaproteobacteria,1JZNA@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_73755_1	278963.ATWD01000001_gene2133	8.34e-79	248.0	COG1060@1|root,COG1060@2|Bacteria,3Y2IA@57723|Acidobacteria,2JIBR@204432|Acidobacteriia	204432|Acidobacteriia	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
k59_138864_1	479431.Namu_2624	2.15e-66	216.0	COG5361@1|root,COG5361@2|Bacteria	2|Bacteria	P	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_138867_1	1123368.AUIS01000001_gene1868	2.17e-139	402.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,1S11K@1236|Gammaproteobacteria,2NBQA@225057|Acidithiobacillales	225057|Acidithiobacillales	E	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_399172_1	1040989.AWZU01000057_gene5081	3.05e-40	144.0	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2U1JI@28211|Alphaproteobacteria,3JUZJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	5.3.3.7	ko:K02020,ko:K22003	ko00660,ko02010,map00660,map02010	M00189	R02244	RC00668	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_302167_1	1125863.JAFN01000001_gene2515	4.96e-74	241.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,43AMW@68525|delta/epsilon subdivisions,2X620@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
k59_335341_1	1288494.EBAPG3_9670	1.67e-181	545.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,37253@32003|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_727418_1	340.xcc-b100_2007	5.22e-48	171.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,1RMM3@1236|Gammaproteobacteria,1X314@135614|Xanthomonadales	135614|Xanthomonadales	EGP	MFS transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_662261_1	1337093.MBE-LCI_3064	1.04e-32	129.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,2P8F7@245186|Loktanella	28211|Alphaproteobacteria	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_499021_1	504728.K649_08270	3.79e-05	45.4	COG0607@1|root,COG0607@2|Bacteria,1WJ03@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_499021_2	1163617.SCD_n00799	1.73e-42	139.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_499021_3	1049564.TevJSym_ax00340	1.97e-08	52.8	COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,1RRM7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_727428_1	1232410.KI421413_gene776	1.46e-55	194.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,42PRD@68525|delta/epsilon subdivisions,2X5MX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_107006_1	1454004.AW11_02854	3e-208	592.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2VP1W@28216|Betaproteobacteria	28216|Betaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_107006_2	1454004.AW11_02853	2.02e-47	154.0	COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria	1224|Proteobacteria	P	COG1006 Multisubunit Na H antiporter, MnhC subunit	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_662266_1	323850.Shew_0984	2.22e-183	518.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQX@1236|Gammaproteobacteria,2QCYP@267890|Shewanellaceae	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_235914_1	640081.Dsui_1396	1.52e-81	256.0	COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VMD2@28216|Betaproteobacteria,2KVQP@206389|Rhodocyclales	206389|Rhodocyclales	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_662270_1	1125863.JAFN01000001_gene912	4.86e-53	189.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_923445_1	94122.Shewana3_0230	2.66e-43	149.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,2Q9PJ@267890|Shewanellaceae	1236|Gammaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECO111_1330.ECO111_2936,iYL1228.KPN_02080	CcmB
k59_662272_1	411154.GFO_0549	1.66e-47	163.0	28K7U@1|root,2Z9VT@2|Bacteria,4NIK4@976|Bacteroidetes,1I4P6@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_499037_1	1266925.JHVX01000005_gene1861	7.77e-97	307.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,371QF@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1016150_1	1463861.JNXE01000030_gene1155	8.53e-07	55.5	COG0583@1|root,COG0583@2|Bacteria,2H8EF@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K11921	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_857509_1	56780.SYN_00126	6.66e-92	280.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MR4Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Type IV secretion-system coupling protein DNA-binding domain	pilT1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_987957_1	1177181.T9A_02427	5.88e-28	106.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1XK2R@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
k59_499041_1	439235.Dalk_5159	7.51e-69	221.0	COG0191@1|root,COG0191@2|Bacteria,1NMAK@1224|Proteobacteria,42NPW@68525|delta/epsilon subdivisions,2WIMN@28221|Deltaproteobacteria,2MHU7@213118|Desulfobacterales	28221|Deltaproteobacteria	G	aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_857511_1	655815.ZPR_0195	4.27e-34	135.0	COG4772@1|root,COG4772@2|Bacteria,4NEJW@976|Bacteroidetes,1HWWZ@117743|Flavobacteriia	976|Bacteroidetes	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_955894_1	1265502.KB905973_gene1327	6.82e-51	164.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2VPZW@28216|Betaproteobacteria,4ADI2@80864|Comamonadaceae	28216|Betaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_955894_2	1265502.KB905973_gene1326	4.14e-110	321.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2VHDK@28216|Betaproteobacteria,4AB95@80864|Comamonadaceae	28216|Betaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_74599_1	290318.Cvib_0214	9.11e-08	58.2	COG0584@1|root,COG0584@2|Bacteria,1FDU3@1090|Chlorobi	1090|Chlorobi	C	PFAM glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_694999_1	1163617.SCD_n02030	3.46e-47	164.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	rbcR	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_204728_1	1197906.CAJQ02000044_gene1617	1.15e-54	173.0	COG2050@1|root,COG2050@2|Bacteria,1RDVV@1224|Proteobacteria,2UANF@28211|Alphaproteobacteria,3K1BX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_204728_2	375286.mma_3265	1.01e-84	256.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,4723E@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_464340_1	1157637.KB892098_gene2015	3.41e-54	190.0	COG2203@1|root,COG5441@1|root,COG2203@2|Bacteria,COG5441@2|Bacteria,2GKDK@201174|Actinobacteria	201174|Actinobacteria	T	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
k59_695000_2	335283.Neut_0276	1.42e-74	232.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,371MG@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_825557_1	595537.Varpa_0016	1.4e-89	273.0	COG0655@1|root,COG0655@2|Bacteria,1MX6A@1224|Proteobacteria,2VH2Z@28216|Betaproteobacteria,4ABSN@80864|Comamonadaceae	28216|Betaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_923471_1	522306.CAP2UW1_0765	2.62e-115	338.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,1KPPU@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_564256_1	1121405.dsmv_1578	1.96e-33	128.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2MHZQ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_499068_1	1123367.C666_17470	4.87e-12	65.9	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2VSHR@28216|Betaproteobacteria,2KW1R@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
k59_499070_1	338963.Pcar_1219	5.91e-08	55.8	COG2378@1|root,COG2378@2|Bacteria,1PE00@1224|Proteobacteria,42T67@68525|delta/epsilon subdivisions,2WMIA@28221|Deltaproteobacteria,43S9S@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
k59_499070_2	518766.Rmar_1973	2.48e-22	94.7	COG1878@1|root,COG1878@2|Bacteria,4PIWM@976|Bacteroidetes,1FJPB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Putative cyclase	-	GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
k59_825569_1	1454004.AW11_02021	5.6e-20	89.7	COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2VKTC@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_302228_1	861299.J421_0531	3.07e-41	154.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
k59_995991_1	1007105.PT7_1576	2.45e-74	248.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,3T6RJ@506|Alcaligenaceae	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_995991_2	395495.Lcho_2156	6.67e-08	53.5	COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2VMJE@28216|Betaproteobacteria,1KKQM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_604855_2	713586.KB900536_gene702	6.89e-56	185.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,1RRSU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	comC	-	1.1.1.338,1.5.1.21	ko:K13609,ko:K16844	ko00270,ko00310,ko00960,ko01100,ko01120,map00270,map00310,map00960,map01100,map01120	-	R02203,R07137	RC00031,RC00135	ko00000,ko00001,ko01000	-	-	-	Ldh_2
k59_212764_1	401526.TcarDRAFT_1043	1.64e-82	258.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,4H23K@909932|Negativicutes	909932|Negativicutes	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_931823_1	330214.NIDE1681	3.61e-44	150.0	COG0805@1|root,COG0805@2|Bacteria,3J0PJ@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_931823_2	330214.NIDE1682	1.67e-59	202.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
k59_931823_3	330214.NIDE1683	3.56e-89	264.0	COG0652@1|root,COG0652@2|Bacteria,3J18H@40117|Nitrospirae	40117|Nitrospirae	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
k59_865568_1	522306.CAP2UW1_0115	1.32e-49	172.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,2VGZN@28216|Betaproteobacteria,1KQIP@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	ko:K03208	-	-	-	-	ko00000	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
k59_931826_1	583345.Mmol_1374	1.81e-37	144.0	COG3850@1|root,COG4585@1|root,COG3850@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VNHG@28216|Betaproteobacteria,2KM0S@206350|Nitrosomonadales	206350|Nitrosomonadales	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3,LapD_MoxY_N,PAS,PAS_9
k59_637260_1	543728.Vapar_1034	8.61e-23	94.7	COG0454@1|root,COG0456@2|Bacteria,1RBE6@1224|Proteobacteria,2VRQ7@28216|Betaproteobacteria,4AEBP@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_637260_2	1250232.JQNJ01000001_gene1416	5.72e-05	44.7	2DWGT@1|root,34096@2|Bacteria,4P4T6@976|Bacteroidetes,1I9UU@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
k59_147965_1	395495.Lcho_4209	3.34e-33	122.0	COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,2VPK0@28216|Betaproteobacteria,1KM9A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_N,Mrr_cat
k59_147965_2	2340.JV46_13870	5.16e-46	153.0	2DZRC@1|root,32VGV@2|Bacteria,1N2PT@1224|Proteobacteria,1SQQ6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
k59_735975_1	661478.OP10G_1547	7.18e-61	201.0	COG1409@1|root,COG3794@1|root,COG1409@2|Bacteria,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1,Metallophos
k59_49761_1	555779.Dthio_PD2274	4.02e-81	267.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,42MEW@68525|delta/epsilon subdivisions,2WJX1@28221|Deltaproteobacteria,2M8X0@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM Malto-oligosyltrehalose synthase	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_765050_1	1121403.AUCV01000043_gene96	1.13e-88	278.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42ME4@68525|delta/epsilon subdivisions,2WJA5@28221|Deltaproteobacteria,2MIGA@213118|Desulfobacterales	28221|Deltaproteobacteria	T	CheY-like receiver, AAA-type ATPase, and DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_147971_1	1267005.KB911255_gene2513	2.15e-23	103.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,3N6MB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Peptidase M23	MA20_20375	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_670750_1	936455.KI421499_gene5723	2.06e-67	216.0	COG0683@1|root,COG0683@2|Bacteria,1MV1Z@1224|Proteobacteria,2TRTD@28211|Alphaproteobacteria,3JS33@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	MA20_18615	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_931841_1	1121405.dsmv_2168	7.38e-79	242.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,42MNY@68525|delta/epsilon subdivisions,2WJ6C@28221|Deltaproteobacteria,2MI5J@213118|Desulfobacterales	28221|Deltaproteobacteria	F	CobB/CobQ-like glutamine amidotransferase domain	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
k59_703593_1	945713.IALB_0013	7e-73	237.0	COG0445@1|root,COG0445@2|Bacteria	2|Bacteria	D	tRNA wobble uridine modification	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_17599_1	365046.Rta_16630	1.16e-48	166.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,4AADX@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	acd12	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_17599_2	1038859.AXAU01000002_gene323	5.1e-48	157.0	COG3193@1|root,COG3193@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Haem_degrading
k59_637277_1	640081.Dsui_1318	9.82e-99	294.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,2KVU7@206389|Rhodocyclales	206389|Rhodocyclales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_834097_1	95619.PM1_0217445	6.36e-37	130.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_834097_2	754477.Q7C_1379	2.1e-93	281.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,46018@72273|Thiotrichales	72273|Thiotrichales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_572628_2	1265502.KB905932_gene1921	1.13e-79	250.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,4ACJH@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM TrkA-N domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_147982_1	1385518.N798_05610	5.71e-104	322.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4FEJS@85021|Intrasporangiaceae	201174|Actinobacteria	L	Helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_604881_1	933262.AXAM01000024_gene711	7.49e-26	112.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42PTW@68525|delta/epsilon subdivisions,2WK32@28221|Deltaproteobacteria,2MK8M@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14.2	-	-	Plug,TonB_dep_Rec
k59_406053_1	1131553.JIBI01000071_gene2157	5.95e-145	424.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,3728D@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_343601_1	518766.Rmar_0905	5.74e-33	124.0	COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes	976|Bacteroidetes	M	mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_1020899_1	159087.Daro_3294	1.45e-79	244.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,2KUZJ@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_766015_1	977880.RALTA_A0228	4.88e-101	303.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VHRM@28216|Betaproteobacteria,1K669@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_508457_1	521674.Plim_1906	3.24e-44	165.0	COG0643@1|root,COG0643@2|Bacteria,2IWWG@203682|Planctomycetes	203682|Planctomycetes	T	Signal transducing histidine kinase, homodimeric	-	-	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_84114_1	1278307.KB906993_gene3326	3.14e-28	118.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,1RQPC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	von willebrand factor, type A	yfbK	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
k59_116413_1	504832.OCAR_4862	2.15e-98	305.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,3JU1V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
k59_508459_1	748280.NH8B_3218	1.36e-103	310.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,2KQFM@206351|Neisseriales	206351|Neisseriales	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	rfaD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
k59_508459_2	153948.NAL212_0624	1.66e-84	258.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,372JI@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_898498_1	1382356.JQMP01000001_gene1252	1.83e-56	186.0	COG0437@1|root,COG0437@2|Bacteria,2G9ZX@200795|Chloroflexi,27Y09@189775|Thermomicrobia	189775|Thermomicrobia	C	4Fe-4S binding domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3
k59_275563_2	380358.XALC_2198	2.03e-44	147.0	COG3759@1|root,COG3759@2|Bacteria,1MZ4F@1224|Proteobacteria,1S90R@1236|Gammaproteobacteria,1X7IR@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	ko:K08987	-	-	-	-	ko00000	-	-	-	DUF1304
k59_737147_1	1353528.DT23_12595	1.36e-19	90.5	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2TR2V@28211|Alphaproteobacteria,2XN5R@285107|Thioclava	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_965617_1	991905.SL003B_2107	7.5e-82	255.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,4BPQA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_275565_1	247634.GPB2148_1808	5.24e-104	314.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1989,GCV_T,GCV_T_C
k59_866727_1	1123255.JHYS01000001_gene2025	3.38e-129	380.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI5E@28216|Betaproteobacteria,4ABQV@80864|Comamonadaceae	28216|Betaproteobacteria	P	nitrite transporter	narK	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_310814_1	1496688.ER33_14890	3.3e-20	94.7	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF4347,DctA-YdbH,Flg_new,He_PIG,SdrD_B
k59_181596_1	330214.NIDE0372	2.45e-43	152.0	COG0055@1|root,COG0055@2|Bacteria,3J0BN@40117|Nitrospirae	40117|Nitrospirae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_181596_2	768670.Calni_1586	1.91e-20	85.1	COG0355@1|root,COG0355@2|Bacteria,2GFNE@200930|Deferribacteres	200930|Deferribacteres	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
k59_243745_1	1382303.JPOM01000001_gene345	1.32e-26	104.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria,2KGHU@204458|Caulobacterales	204458|Caulobacterales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_243745_2	300852.55773164	1.2e-29	107.0	COG0211@1|root,COG0211@2|Bacteria,1WKBG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_638360_1	1458275.AZ34_00980	1.29e-11	68.6	COG0745@1|root,COG0745@2|Bacteria,1Q2S0@1224|Proteobacteria,2VM6W@28216|Betaproteobacteria,4AAMQ@80864|Comamonadaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator	ompR2	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_638360_2	983917.RGE_00990	6.41e-05	44.3	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2VHJF@28216|Betaproteobacteria,1KJ7F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_997186_1	983545.Glaag_0837	9.56e-13	68.6	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,464CX@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_997186_2	323848.Nmul_A2501	1.2e-28	106.0	COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,373NV@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
k59_997186_3	582744.Msip34_0454	6.21e-42	154.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,2KM24@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_898525_1	1282876.BAOK01000002_gene898	8.28e-92	281.0	COG1960@1|root,COG1960@2|Bacteria,1P8I7@1224|Proteobacteria,2U0AW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_606036_1	153948.NAL212_0710	3.39e-13	73.9	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,2WBQH@28216|Betaproteobacteria,3747Z@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_997192_1	1266925.JHVX01000005_gene1874	5.3e-157	449.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,372PV@32003|Nitrosomonadales	28216|Betaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_997192_2	196367.JNFG01000025_gene8283	2.23e-09	57.8	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,1K0RE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_243761_1	945713.IALB_0171	8.99e-83	267.0	COG0474@1|root,COG0474@2|Bacteria	2|Bacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.2,3.6.3.6	ko:K01531,ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3,3.A.3.4	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_275578_1	879212.DespoDRAFT_00038	7.62e-14	71.6	2C5J8@1|root,30F9Z@2|Bacteria,1RE16@1224|Proteobacteria,42RYB@68525|delta/epsilon subdivisions,2WNIF@28221|Deltaproteobacteria,2MJSR@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_275578_2	1121405.dsmv_1549	3.02e-30	117.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42MRE@68525|delta/epsilon subdivisions,2WIP0@28221|Deltaproteobacteria,2MIDJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_181624_1	1049564.TevJSym_am00780	1.81e-75	234.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,1J4QD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_866756_1	420662.Mpe_A3564	1.95e-77	239.0	COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,1KK13@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_213932_1	1229909.NSED_00110	7.7e-77	239.0	COG1903@1|root,arCOG04383@2157|Archaea,41S70@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
k59_898552_1	945713.IALB_0783	1.52e-49	171.0	COG2987@1|root,COG2987@2|Bacteria	2|Bacteria	E	urocanate hydratase activity	hutU	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016153,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_0688	Urocanase,Urocanase_C,Urocanase_N
k59_898552_3	945713.IALB_0785	2.54e-15	74.7	COG1816@1|root,COG1816@2|Bacteria	2|Bacteria	F	deaminase activity	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
k59_181640_1	335543.Sfum_2378	1.44e-87	273.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,42MST@68525|delta/epsilon subdivisions,2WKAN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_737212_1	671143.DAMO_0532	2.95e-108	346.0	COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_344746_1	1502850.FG91_00576	3.34e-59	194.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2U0DE@28211|Alphaproteobacteria,2K0K6@204457|Sphingomonadales	204457|Sphingomonadales	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_965667_1	189753.AXAS01000041_gene2534	2.25e-43	154.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_866768_1	641107.CDLVIII_5310	1.48e-43	159.0	COG4467@1|root,COG4467@2|Bacteria,1VK8R@1239|Firmicutes,24979@186801|Clostridia	186801|Clostridia	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_243780_1	390235.PputW619_4687	2.4e-84	269.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1YW8N@136845|Pseudomonas putida group	1236|Gammaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_18797_1	314231.FP2506_10511	7.37e-71	238.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2PJ4M@255475|Aurantimonadaceae	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_835324_1	420662.Mpe_A3778	8.07e-99	299.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2VJE2@28216|Betaproteobacteria,1KJME@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
k59_835324_2	1223521.BBJX01000005_gene1960	5.02e-09	55.8	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2VI2M@28216|Betaproteobacteria,4ACEV@80864|Comamonadaceae	28216|Betaproteobacteria	T	PrkA serine kinase	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_681168_1	1131266.ARWQ01000001_gene1153	4.08e-74	243.0	COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_614827_1	1265502.KB905948_gene1003	1.6e-70	233.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,4AC6C@80864|Comamonadaceae	28216|Betaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_353510_1	596151.DesfrDRAFT_1246	1.72e-30	118.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria,2MAT0@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
k59_93306_1	323261.Noc_0830	9.89e-92	296.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales	135613|Chromatiales	G	alpha amylase catalytic	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_1005745_1	1379698.RBG1_1C00001G0780	9.71e-85	261.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
k59_647160_2	1382356.JQMP01000003_gene2134	2.79e-12	68.2	COG0477@1|root,COG0477@2|Bacteria,2G5YG@200795|Chloroflexi,27XKV@189775|Thermomicrobia	189775|Thermomicrobia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_942144_1	640512.BC1003_1291	1.2e-32	118.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,1JZWS@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_942144_2	62928.azo1905	1.35e-45	154.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,2KV64@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_583022_1	639030.JHVA01000001_gene135	5.21e-35	122.0	COG3526@1|root,COG3526@2|Bacteria	2|Bacteria	O	Rdx family	-	-	-	ko:K07401	-	-	-	-	ko00000	-	-	-	Rdx
k59_583022_2	1532558.JL39_27620	1.17e-07	52.0	COG0782@1|root,COG0782@2|Bacteria,1RHU5@1224|Proteobacteria,2U95I@28211|Alphaproteobacteria,4BE4M@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcription elongation factor	greB	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB
k59_1006699_1	876044.IMCC3088_2538	1.92e-73	239.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RYI9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_280741_1	631454.N177_0653	1.42e-46	157.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2U0TW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_280741_2	631454.N177_0654	1.41e-15	77.0	COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2TWGB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_943169_1	889378.Spiaf_0482	6.48e-79	246.0	COG0205@1|root,COG0205@2|Bacteria,2J5F8@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_126281_1	1266925.JHVX01000007_gene2340	2.07e-43	152.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2VSTA@28216|Betaproteobacteria,372KI@32003|Nitrosomonadales	28216|Betaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
k59_682239_1	1123392.AQWL01000006_gene632	2.52e-112	337.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2VKBR@28216|Betaproteobacteria,1KSWH@119069|Hydrogenophilales	119069|Hydrogenophilales	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_682239_2	388051.AUFE01000043_gene3295	1.04e-26	103.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2VJTI@28216|Betaproteobacteria,1K3P7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	hydrogenase 4 membrane	hyfE	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_223462_1	1121405.dsmv_3022	1.71e-39	140.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WQZU@28221|Deltaproteobacteria,2MNMU@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	Rod-binding,SLT
k59_451573_1	1121875.KB907546_gene2198	7.88e-41	152.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_1025905_1	1304883.KI912532_gene1972	2.27e-102	311.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales	206389|Rhodocyclales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_354569_1	580332.Slit_2622	3.63e-31	122.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,44VD5@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_354569_2	568706.BN118_3459	3.39e-70	220.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,3T1R7@506|Alcaligenaceae	28216|Betaproteobacteria	H	Molybdopterin biosynthesis protein MoeB	thiF	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_60319_1	330214.NIDE4133	5.76e-92	293.0	COG0532@1|root,COG0532@2|Bacteria,3J0CC@40117|Nitrospirae	40117|Nitrospirae	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_60319_2	1379698.RBG1_1C00001G1154	1.01e-08	53.5	COG1550@1|root,COG1550@2|Bacteria,2NPYX@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF503)	ylxP	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
k59_682249_1	936136.ARRT01000007_gene1278	6.62e-58	201.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_615870_1	1121904.ARBP01000005_gene4640	2.13e-23	104.0	COG2208@1|root,COG2208@2|Bacteria,4NHV8@976|Bacteroidetes,47THS@768503|Cytophagia	976|Bacteroidetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,SpoIIE
k59_223476_1	395494.Galf_1868	1.5e-39	146.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,44VAI@713636|Nitrosomonadales	28216|Betaproteobacteria	L	HELICc2	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k59_223476_2	381666.H16_A1575	4.47e-44	148.0	COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,2VSZM@28216|Betaproteobacteria,1KDH5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_94379_1	1454004.AW11_00191	1.79e-85	271.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VMX9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_518721_1	870187.Thini_2175	1.73e-28	114.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,45ZVX@72273|Thiotrichales	72273|Thiotrichales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_518721_2	666681.M301_1652	3.05e-06	48.1	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,2KKZ1@206350|Nitrosomonadales	206350|Nitrosomonadales	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_774920_1	626418.bglu_2g08400	5.81e-71	223.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,1K0TQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_354595_1	983548.Krodi_1757	3.01e-14	78.6	COG1361@1|root,COG3291@1|root,COG4932@1|root,COG5184@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,4NDZC@976|Bacteroidetes	976|Bacteroidetes	DZ	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
k59_908026_1	1122604.JONR01000001_gene1778	1.28e-202	566.0	2C1EV@1|root,33RW1@2|Bacteria,1R3AA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_943207_1	1288494.EBAPG3_16510	7.96e-45	153.0	COG4455@1|root,COG4455@2|Bacteria,1MWHI@1224|Proteobacteria,2VKHG@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Virulence protein SciE type	-	-	-	ko:K11898	-	-	-	-	ko00000,ko02044	-	-	-	ImpE
k59_280758_1	1380355.JNIJ01000041_gene5219	6.66e-109	325.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_480566_1	1500257.JQNM01000006_gene2115	1.21e-35	137.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_19,TPR_8,Trans_reg_C
k59_223498_1	1229909.NSED_06330	2.22e-78	241.0	COG0505@1|root,arCOG00064@2157|Archaea,41SF0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_126313_1	571166.KI421509_gene3640	1.9e-30	122.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,2TSJC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit	nuoL3	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_126313_3	1454004.AW11_02855	1.36e-200	571.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2VPQP@28216|Betaproteobacteria	28216|Betaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_415696_1	335543.Sfum_0451	3.63e-90	293.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MR8V@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_158974_2	1125973.JNLC01000011_gene454	5.74e-39	137.0	2BKYI@1|root,32FF5@2|Bacteria,1RB6X@1224|Proteobacteria,2VER9@28211|Alphaproteobacteria,3JY0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	MA20_15120	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_386060_1	1168059.KB899087_gene1455	1.87e-18	83.6	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2TV1D@28211|Alphaproteobacteria,3EZ9W@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_386060_2	543728.Vapar_6055	3.12e-32	116.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2VQ5D@28216|Betaproteobacteria,4ADG2@80864|Comamonadaceae	1224|Proteobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,YjgF_endoribonc
k59_94404_1	314264.ROS217_07340	4.41e-24	96.3	2E46N@1|root,32Z2M@2|Bacteria,1N6SH@1224|Proteobacteria,2UHDJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_747485_1	1265502.KB905932_gene1781	3.35e-103	309.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2VK9D@28216|Betaproteobacteria,4A9VN@80864|Comamonadaceae	28216|Betaproteobacteria	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_715014_1	265072.Mfla_1709	2.28e-124	361.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,2KKJ5@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_943213_1	420324.KI912069_gene6461	6.23e-86	279.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JSYN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
k59_615900_1	926569.ANT_26050	1.55e-82	248.0	COG5433@1|root,COG5433@2|Bacteria,2G91M@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_975999_1	522306.CAP2UW1_2539	8.77e-80	246.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria,1KPZ2@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_252396_1	1121448.DGI_1886	5.24e-37	135.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2M8CM@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3708
k59_252396_2	1265505.ATUG01000001_gene3101	4.11e-49	170.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,2MJ8E@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Domain of unknown function (DUF3333)	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_60364_1	96561.Dole_0884	8.68e-17	82.0	COG2116@1|root,COG2204@1|root,COG2116@2|Bacteria,COG2204@2|Bacteria,1MU0W@1224|Proteobacteria,42Q34@68525|delta/epsilon subdivisions,2WN9I@28221|Deltaproteobacteria,2MKB5@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM formate nitrite transporter	fdhC	-	-	ko:K06212,ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.2	-	-	Form_Nir_trans,Response_reg
k59_793878_1	292459.STH2279	1.32e-36	138.0	COG3328@1|root,COG3328@2|Bacteria,1V116@1239|Firmicutes,24D8K@186801|Clostridia	186801|Clostridia	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_28727_1	1458275.AZ34_10130	7.87e-22	87.8	COG4315@1|root,COG4315@2|Bacteria,1MZC6@1224|Proteobacteria,2VU7D@28216|Betaproteobacteria,4AEXB@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Secreted repeat of	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
k59_28727_2	1163617.SCD_n00186	6.82e-58	185.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE8	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_28727_3	1349767.GJA_4806	0.000374	41.2	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	prtR	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
k59_715017_1	1175306.GWL_12160	5.51e-15	75.5	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,472FQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_715017_2	1163617.SCD_n00951	1.12e-87	273.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_1006759_2	748727.CLJU_c15740	6.12e-26	110.0	COG2199@1|root,COG2206@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia,36USB@31979|Clostridiaceae	186801|Clostridia	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9
k59_386070_1	1453501.JELR01000005_gene1616	2.15e-106	330.0	COG3391@1|root,COG3391@2|Bacteria,1RA6R@1224|Proteobacteria,1SE8J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_354625_1	10224.XP_002734285.1	7.98e-77	244.0	KOG4585@1|root,KOG4585@2759|Eukaryota,39THK@33154|Opisthokonta,3BGF1@33208|Metazoa,3D09T@33213|Bilateria	33208|Metazoa	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4
k59_518754_1	864051.BurJ1DRAFT_2335	3.59e-44	146.0	COG3628@1|root,COG3628@2|Bacteria,1NCAC@1224|Proteobacteria,2VX33@28216|Betaproteobacteria,1KNP5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
k59_518754_2	864051.BurJ1DRAFT_2336	8.65e-34	128.0	28NRK@1|root,2ZBQU@2|Bacteria,1RAJN@1224|Proteobacteria,2VW16@28216|Betaproteobacteria,1KN0H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_354630_1	357808.RoseRS_1789	1.6e-05	53.1	COG0006@1|root,COG0006@2|Bacteria,2G5J8@200795|Chloroflexi,376NM@32061|Chloroflexia	32061|Chloroflexia	E	PFAM peptidase M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_648208_1	420324.KI912086_gene7328	7.2e-71	226.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,1JU3D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3,DUF1643
k59_1006767_1	1279009.ADICEAN_00002	1.42e-68	222.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes	976|Bacteroidetes	M	peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_715031_2	436308.Nmar_0324	1.99e-92	273.0	COG0522@1|root,arCOG04239@2157|Archaea,41SN3@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S4
k59_943235_1	1073999.BN137_596	4.12e-35	132.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,1RZC6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	thuF	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
k59_917380_1	1216007.AOPM01000034_gene3328	2.06e-95	287.0	COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria,1RPI5@1236|Gammaproteobacteria,2Q3UK@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	G	Glycosyl hydrolases family 43	abnA	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43
k59_492959_1	1313172.YM304_08350	1.01e-50	162.0	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4CMZN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_492959_2	1313172.YM304_08360	1.16e-54	172.0	COG0198@1|root,COG0198@2|Bacteria,2HGDN@201174|Actinobacteria,4CNBW@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_35769_1	582744.Msip34_0586	1.54e-105	316.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,2KKCS@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_558212_1	113395.AXAI01000009_gene2580	4.01e-53	181.0	COG0247@1|root,COG0247@2|Bacteria,1R4HN@1224|Proteobacteria,2U3WW@28211|Alphaproteobacteria,3JXJX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4
k59_133707_1	235985.BBPN01000024_gene1730	1.04e-39	144.0	COG0204@1|root,COG0204@2|Bacteria,2GJKH@201174|Actinobacteria,2NEB7@228398|Streptacidiphilus	201174|Actinobacteria	I	Phosphate acyltransferases	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_264297_1	1415779.JOMH01000001_gene650	8.1e-63	206.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1X3KV@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_101029_1	1382359.JIAL01000001_gene774	1.79e-186	532.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,3Y2FA@57723|Acidobacteria,2JI4J@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_1013335_1	744980.TRICHSKD4_0403	1.34e-106	319.0	COG3839@1|root,COG3839@2|Bacteria,1MU7W@1224|Proteobacteria,2TQNF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	MA20_44790	-	-	ko:K17325	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	ABC_tran,TOBE_2
k59_492975_1	330214.NIDE0232	2.93e-116	357.0	COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae	2|Bacteria	C	Molydopterin dinucleotide binding domain	hcnA	-	1.4.99.5,1.5.3.1	ko:K00302,ko:K10814	ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110	-	R00374,R00610,R05704	RC00060,RC00557,RC02808	ko00000,ko00001,ko01000,ko02042	-	-	-	Fer2_4
k59_264305_1	768671.ThimaDRAFT_4529	1.54e-63	201.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_264307_2	1198232.CYCME_1188	2.64e-46	159.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,461U1@72273|Thiotrichales	72273|Thiotrichales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_231275_1	999141.GME_08679	2.22e-05	47.8	COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria,1XMFR@135619|Oceanospirillales	135619|Oceanospirillales	NU	COG4967 Tfp pilus assembly protein PilV	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
k59_231275_2	388051.AUFE01000067_gene3791	8.27e-19	85.9	COG4970@1|root,COG4970@2|Bacteria,1NGHS@1224|Proteobacteria,2WCQW@28216|Betaproteobacteria,1K9MD@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	type 4 fimbrial pilin related transmembrane protein	fimT	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_231275_3	207954.MED92_18228	3.5e-12	67.0	COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,1XMB2@135619|Oceanospirillales	135619|Oceanospirillales	NU	Type IV minor pilin ComP, DNA uptake sequence receptor	-	-	-	-	-	-	-	-	-	-	-	-	ComP_DUS,N_methyl
k59_784567_1	94624.Bpet0302	6.42e-30	118.0	COG3181@1|root,COG3181@2|Bacteria,1R4JE@1224|Proteobacteria,2VJTF@28216|Betaproteobacteria,3T6RR@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_784567_2	706587.Desti_1807	6.28e-12	65.1	COG2186@1|root,COG2186@2|Bacteria,1MUP9@1224|Proteobacteria,42S04@68525|delta/epsilon subdivisions,2WP08@28221|Deltaproteobacteria,2MSJD@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
k59_199002_1	555779.Dthio_PD3821	1.69e-101	310.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2M8VR@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_819500_1	697282.Mettu_1327	4.68e-49	161.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1XEGS@135618|Methylococcales	135618|Methylococcales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_35806_1	1038858.AXBA01000001_gene3481	2.53e-13	74.7	COG1529@1|root,COG3427@1|root,COG1529@2|Bacteria,COG3427@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.3.99.8	ko:K16877	ko00365,ko01120,map00365,map01120	-	R02987	RC01856	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,COXG
k59_329480_1	1278073.MYSTI_05156	1.01e-46	172.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
k59_688884_1	945713.IALB_0171	4.92e-68	227.0	COG0474@1|root,COG0474@2|Bacteria	2|Bacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.2,3.6.3.6	ko:K01531,ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3,3.A.3.4	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_394506_1	1120792.JAFV01000001_gene1338	1.7e-79	251.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria,36ZJB@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_264330_1	351348.Maqu_2996	3.44e-07	52.0	COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,1RSB2@1236|Gammaproteobacteria,466PK@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
k59_264330_2	748247.AZKH_4595	1.06e-126	364.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2VJUP@28216|Betaproteobacteria,2KV7I@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC transporter, ATP-binding protein	urtE	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
k59_264330_3	62928.azo0677	3.06e-48	161.0	COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2VIX4@28216|Betaproteobacteria,2KUB2@206389|Rhodocyclales	206389|Rhodocyclales	S	Urea ABC transporter ATP-binding protein urtd	urtD	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran,BCA_ABC_TP_C
k59_590794_1	1234364.AMSF01000030_gene3438	1.15e-54	189.0	COG0644@1|root,COG0644@2|Bacteria,1MZ3Z@1224|Proteobacteria,1S47W@1236|Gammaproteobacteria,1X4IT@135614|Xanthomonadales	135614|Xanthomonadales	C	Halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
k59_1013348_1	797302.Halru_2914	6.34e-17	83.2	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,23WZT@183963|Halobacteria	183963|Halobacteria	S	metal-dependent membrane protease	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_656218_1	690850.Desaf_2891	1.03e-68	214.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42R03@68525|delta/epsilon subdivisions,2WMTZ@28221|Deltaproteobacteria,2MCTY@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_982213_1	1205680.CAKO01000042_gene5416	2.12e-55	185.0	COG0715@1|root,COG0715@2|Bacteria,1MWC5@1224|Proteobacteria,2TSS8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_68547_1	1121957.ATVL01000002_gene2485	3.29e-34	135.0	COG0582@1|root,COG0582@2|Bacteria,4PP71@976|Bacteroidetes,47RVB@768503|Cytophagia	976|Bacteroidetes	L	Phage integrase SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_5,Phage_int_SAM_5,Phage_integrase
k59_917434_1	1248232.BANQ01000013_gene973	1.23e-57	201.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XUAZ@135623|Vibrionales	135623|Vibrionales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_35809_2	296591.Bpro_0064	1.97e-57	183.0	2BVK0@1|root,32QXS@2|Bacteria,1RKSK@1224|Proteobacteria,2VTQ9@28216|Betaproteobacteria,4AI5Z@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_35809_3	279714.FuraDRAFT_0206	3.58e-40	138.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2WG03@28216|Betaproteobacteria,2KS22@206351|Neisseriales	206351|Neisseriales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_35809_5	1123367.C666_12150	5.84e-85	277.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales	206389|Rhodocyclales	CM	Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_101080_1	1026882.MAMP_00768	2.81e-61	203.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,4605J@72273|Thiotrichales	72273|Thiotrichales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_296768_1	945713.IALB_0815	0.000297	43.5	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398,LysM,SAM_adeno_trans,Y_phosphatase3
k59_590809_1	926569.ANT_26040	1.73e-25	103.0	COG5433@1|root,COG5433@2|Bacteria,2G91G@200795|Chloroflexi	200795|Chloroflexi	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_assoc
k59_101081_2	439235.Dalk_4925	1.25e-13	67.0	2EAIM@1|root,334MN@2|Bacteria,1Q4JY@1224|Proteobacteria,42XPC@68525|delta/epsilon subdivisions,2WT7M@28221|Deltaproteobacteria,2MPQQ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_101081_3	1500257.JQNM01000010_gene766	1.02e-08	57.8	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,2TSJC@28211|Alphaproteobacteria,4B90D@82115|Rhizobiaceae	28211|Alphaproteobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	nuoL3	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_493028_1	757424.Hsero_2164	1.36e-75	247.0	COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,475YA@75682|Oxalobacteraceae	28216|Betaproteobacteria	NT	methyl-accepting chemotaxis	-	-	-	ko:K03406,ko:K03776,ko:K05874	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,sCache_2
k59_688911_1	1121405.dsmv_3402	3.91e-102	308.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2MHTR@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_851786_1	1380394.JADL01000002_gene1420	1.04e-97	297.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria,2JV5I@204441|Rhodospirillales	204441|Rhodospirillales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_819542_1	1123508.JH636440_gene2902	5.1e-35	139.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_851790_1	1123367.C666_13520	1.74e-50	171.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,2KUBZ@206389|Rhodocyclales	206389|Rhodocyclales	S	Permease YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_851790_2	626418.bglu_1g26120	7.33e-28	108.0	COG1714@1|root,COG1714@2|Bacteria,1REEC@1224|Proteobacteria,2VRE0@28216|Betaproteobacteria,1K0CS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_166407_1	663610.JQKO01000010_gene2183	1.36e-33	132.0	COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria,3N9ZF@45404|Beijerinckiaceae	28211|Alphaproteobacteria	CT	Adenylyl- / guanylyl cyclase, catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Guanylate_cyc
k59_231318_1	580332.Slit_1269	4.46e-59	196.0	COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,PEGA
k59_231321_1	706587.Desti_2685	1.42e-52	178.0	COG2421@1|root,COG2421@2|Bacteria,1N12N@1224|Proteobacteria,42WG0@68525|delta/epsilon subdivisions,2WSEJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
k59_884268_1	1210884.HG799469_gene13989	3.42e-24	105.0	COG4287@1|root,COG4287@2|Bacteria,2IYKE@203682|Planctomycetes	203682|Planctomycetes	S	PhoPQ-activated pathogenicity-related protein	-	-	-	-	-	-	-	-	-	-	-	-	PhoPQ_related
k59_231324_1	1156919.QWC_13732	1.98e-43	155.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,3T2A2@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_558306_1	1150469.RSPPHO_01863	1.28e-90	280.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2TU0F@28211|Alphaproteobacteria,2JR6M@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_166420_1	330214.NIDE0568	1.09e-105	328.0	COG0178@1|root,COG0178@2|Bacteria,3J0C7@40117|Nitrospirae	40117|Nitrospirae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_525543_1	1216007.AOPM01000052_gene2198	7.27e-09	62.4	COG0845@1|root,COG0845@2|Bacteria,1N0BG@1224|Proteobacteria,1RMXD@1236|Gammaproteobacteria,2Q0UW@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_949878_1	269796.Rru_A3318	2.95e-44	158.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,2JRCE@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_427415_1	330214.NIDE3890	1.79e-50	165.0	COG0723@1|root,COG0723@2|Bacteria,3J0TT@40117|Nitrospirae	40117|Nitrospirae	C	Rieske [2Fe-2S] domain	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
k59_427415_2	330214.NIDE3925	1.04e-137	399.0	COG0446@1|root,COG0446@2|Bacteria,3J102@40117|Nitrospirae	40117|Nitrospirae	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_101119_1	485913.Krac_6795	2.44e-65	210.0	COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi	200795|Chloroflexi	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k59_949879_2	748247.AZKH_0119	1.67e-65	202.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,2KWEP@206389|Rhodocyclales	206389|Rhodocyclales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_982263_1	391615.ABSJ01000054_gene1465	4.89e-105	317.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1J4NS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_362071_2	1410620.SHLA_98c000140	1.53e-55	181.0	COG0625@1|root,COG0625@2|Bacteria,1MWY4@1224|Proteobacteria,2VEUH@28211|Alphaproteobacteria,4BAHP@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	gstA	GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0006950,GO:0008150,GO:0009635,GO:0009636,GO:0016740,GO:0016765,GO:0032991,GO:0042221,GO:0042802,GO:0042803,GO:0046983,GO:0050896	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_525553_1	330214.NIDE1291	9.34e-85	270.0	COG0210@1|root,COG0210@2|Bacteria,3J0VX@40117|Nitrospirae	40117|Nitrospirae	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_167382_2	497321.C664_12265	1.88e-78	246.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,2KUM2@206389|Rhodocyclales	206389|Rhodocyclales	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_983198_1	485913.Krac_8895	4.6e-33	131.0	COG5433@1|root,COG5433@2|Bacteria,2G91M@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_4076_1	439235.Dalk_1046	1.16e-69	234.0	COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2MHZB@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_885153_1	1183438.GKIL_1487	9.92e-09	63.2	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1FZWU@1117|Cyanobacteria	1117|Cyanobacteria	T	Diguanylate cyclase with PAS PAC and GAF sensors	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9
k59_265308_1	83406.HDN1F_15810	1.43e-35	137.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1J5JM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NT	Methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
k59_885154_1	76114.ebA6426	1.11e-13	70.5	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_885154_2	748247.AZKH_p0052	4.61e-92	276.0	COG3301@1|root,COG3301@2|Bacteria,1MXQ9@1224|Proteobacteria,2VJBF@28216|Betaproteobacteria,2KUPF@206389|Rhodocyclales	206389|Rhodocyclales	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_852692_1	313594.PI23P_08225	1.06e-48	173.0	COG4805@1|root,COG4805@2|Bacteria,4NFAK@976|Bacteroidetes,1HXAT@117743|Flavobacteriia,3VX9I@52959|Polaribacter	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_820499_1	215803.DB30_5233	4.51e-17	90.1	COG4733@1|root,COG4733@2|Bacteria,1QX65@1224|Proteobacteria,43BYR@68525|delta/epsilon subdivisions,2X79M@28221|Deltaproteobacteria,2YZ8E@29|Myxococcales	28221|Deltaproteobacteria	G	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
k59_754280_1	485913.Krac_2926	5.95e-14	79.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2G7W3@200795|Chloroflexi	200795|Chloroflexi	K	transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,NB-ARC,TPR_12
k59_134811_1	395493.BegalDRAFT_3125	8.57e-103	310.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,1RPTT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iPC815.YPO3806,iSDY_1059.SDY_3605	BPD_transp_2,DUF3382
k59_657250_1	580332.Slit_0531	1.98e-76	237.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,44W64@713636|Nitrosomonadales	28216|Betaproteobacteria	T	SMART protein phosphatase 2C domain protein	pppL	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_860640_2	1123368.AUIS01000015_gene2649	1.28e-15	77.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,1MX4M@1224|Proteobacteria,1RPB1@1236|Gammaproteobacteria,2NCA8@225057|Acidithiobacillales	225057|Acidithiobacillales	P	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_730850_1	2074.JNYD01000015_gene4383	1.91e-36	129.0	COG5485@1|root,COG5485@2|Bacteria,2HPCE@201174|Actinobacteria,4E7T2@85010|Pseudonocardiales	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
k59_207952_1	1379698.RBG1_1C00001G1724	3.22e-60	197.0	COG0845@1|root,COG0845@2|Bacteria,2NR7K@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mdtA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_787572_1	436308.Nmar_0424	4.83e-20	86.3	COG1208@1|root,arCOG00663@2157|Archaea	2157|Archaea	M	PFAM Nucleotidyl transferase	-	-	2.6.1.37,2.7.7.13	ko:K00966,ko:K03430	ko00051,ko00440,ko00520,ko01100,ko01110,ko01120,map00051,map00440,map00520,map01100,map01110,map01120	M00114,M00361,M00362	R00885,R04152	RC00002,RC00008,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	NTP_transferase
k59_787572_2	436308.Nmar_0423	7.96e-57	181.0	COG0066@1|root,arCOG02230@2157|Archaea,41T1U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	3-isopropylmalate dehydratase, small subunit	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_600029_1	522306.CAP2UW1_3047	1.49e-09	58.5	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Extracellular solute-binding protein	oppA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_600029_2	228410.NE1153	5.94e-64	204.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,37232@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_926801_1	580332.Slit_1594	7.33e-15	80.5	COG2202@1|root,COG2203@1|root,COG2972@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2972@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2WEET@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,dCache_1
k59_502418_1	1366050.N234_10420	4.91e-97	296.0	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria,2VZQY@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k59_698450_1	1198452.Jab_2c14590	1e-28	113.0	2910Q@1|root,2ZNNC@2|Bacteria,1PCP3@1224|Proteobacteria,2W2XM@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_467105_2	1089551.KE386572_gene3928	1.51e-06	50.1	2EJ3N@1|root,33CUX@2|Bacteria,1Q4IP@1224|Proteobacteria,2UN8J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_12636_1	1266925.JHVX01000005_gene1872	2.88e-86	265.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,37205@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_12636_2	1163617.SCD_n02485	6.26e-147	427.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_12636_3	1266925.JHVX01000005_gene1869	6.91e-128	378.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,3729Y@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_959345_1	1100720.ALKN01000028_gene2547	1.59e-05	45.4	COG1734@1|root,COG1734@2|Bacteria,1NA1P@1224|Proteobacteria,2VX46@28216|Betaproteobacteria,4AFF7@80864|Comamonadaceae	28216|Betaproteobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_959345_2	1380394.JADL01000003_gene4758	5.18e-42	147.0	COG0412@1|root,COG0412@2|Bacteria,1QZFP@1224|Proteobacteria	1224|Proteobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_110344_1	324602.Caur_2832	2e-37	143.0	COG4770@1|root,COG4770@2|Bacteria,2GBIE@200795|Chloroflexi,374S0@32061|Chloroflexia	32061|Chloroflexia	I	Carbamoyl-phosphate synthetase large chain domain protein	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_238654_1	1298867.AUES01000008_gene5202	4.92e-89	300.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_926817_1	1384054.N790_00605	6.92e-38	142.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1X43X@135614|Xanthomonadales	135614|Xanthomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_467113_1	436308.Nmar_0258	1.18e-07	52.4	COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota	651137|Thaumarchaeota	C	fumarate reductase flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_467113_2	1229909.NSED_01185	7.32e-64	197.0	COG1695@1|root,arCOG00002@2157|Archaea,41SN8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_760891_1	493475.GARC_1422	2.57e-43	161.0	COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,1RP10@1236|Gammaproteobacteria,465FE@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_600063_1	858215.Thexy_0045	5.89e-50	179.0	COG2203@1|root,COG2206@1|root,COG3850@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3850@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,42GDE@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GAF,GAF_2,HAMP,HD,HD_5,PAS_9,PocR,Response_reg
k59_44977_1	338969.Rfer_0799	1.18e-116	346.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,4ABAY@80864|Comamonadaceae	28216|Betaproteobacteria	U	type II secretion system protein E	cpaF1	-	-	ko:K02283,ko:K20527	ko02024,map02024	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.7.4	-	-	T2SSE
k59_760903_1	543728.Vapar_0483	1.95e-50	167.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2VSQF@28216|Betaproteobacteria,4AE14@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
k59_44979_1	436308.Nmar_1320	2.28e-15	74.7	COG1205@1|root,arCOG00555@2157|Archaea,41SZS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_44979_2	1229909.NSED_07315	4.95e-146	417.0	COG1028@1|root,arCOG01259@2157|Archaea,41SGH@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_175685_1	1459636.NTE_02683	7.19e-90	270.0	COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_467128_1	1279017.AQYJ01000027_gene1917	9e-54	178.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,466UT@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1	mip	-	5.2.1.8	ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
k59_305300_1	1123393.KB891316_gene1982	4.68e-23	99.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2VKBR@28216|Betaproteobacteria,1KSWH@119069|Hydrogenophilales	119069|Hydrogenophilales	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_305300_2	296591.Bpro_0918	4.12e-88	264.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2VJTI@28216|Betaproteobacteria,4AC7I@80864|Comamonadaceae	28216|Betaproteobacteria	C	hydrogenase 4 membrane	hyfE	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_208014_1	1266925.JHVX01000001_gene2612	2.99e-66	228.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,3727F@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_600071_1	1267211.KI669560_gene722	1.45e-60	196.0	COG1013@1|root,COG1013@2|Bacteria,4NIE0@976|Bacteroidetes,1IZ5W@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase beta subunit	oorB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_600071_2	1123270.ATUR01000003_gene885	5.28e-12	66.2	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2K2JW@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_698487_1	502025.Hoch_2165	4.13e-35	135.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_730919_1	399795.CtesDRAFT_PD5383	1.41e-32	124.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,4A9XB@80864|Comamonadaceae	28216|Betaproteobacteria	E	amino acid	urtA	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
k59_305301_1	187272.Mlg_1415	3.74e-07	56.6	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1WW0S@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III, delta'	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_698490_1	748247.AZKH_p0052	2.83e-58	187.0	COG3301@1|root,COG3301@2|Bacteria,1MXQ9@1224|Proteobacteria,2VJBF@28216|Betaproteobacteria,2KUPF@206389|Rhodocyclales	206389|Rhodocyclales	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_698490_2	748247.AZKH_p0051	6.7e-49	161.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VK6R@28216|Betaproteobacteria,2KVYG@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4
k59_892949_1	1121396.KB892902_gene2314	4.44e-08	53.9	28MMZ@1|root,2ZAXK@2|Bacteria,1R7WU@1224|Proteobacteria,42QIC@68525|delta/epsilon subdivisions,2WKJJ@28221|Deltaproteobacteria,2MJD3@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_892949_2	1033743.CAES01000018_gene2556	6.33e-24	100.0	COG1089@1|root,COG1089@2|Bacteria,1UJFF@1239|Firmicutes,4HF5Y@91061|Bacilli,275YJ@186822|Paenibacillaceae	91061|Bacilli	M	Polysaccharide biosynthesis protein	-	-	1.1.1.281	ko:K15856	ko00051,ko00520,map00051,map00520	-	R03397,R03399	RC00182	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_787594_1	1437824.BN940_17786	1.73e-49	167.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,3T1EJ@506|Alcaligenaceae	28216|Betaproteobacteria	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_467147_2	1266925.JHVX01000011_gene1518	6.96e-65	212.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,371KY@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_991259_1	314285.KT71_05772	5.18e-61	204.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1J8Q2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF2	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_12690_1	696747.NIES39_E04160	5.36e-61	208.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1G2KN@1117|Cyanobacteria,1HBXR@1150|Oscillatoriales	1117|Cyanobacteria	EH	Amino-transferase class IV	-	-	2.6.1.85,4.1.3.38	ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
k59_401977_1	945713.IALB_2730	2.43e-54	190.0	COG0457@1|root,COG2755@1|root,COG0457@2|Bacteria,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Lipase_GDSL_2,SLH,TPR_19,TPR_8
k59_305325_2	1304883.KI912532_gene3056	4.24e-17	80.9	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VPAD@28216|Betaproteobacteria,2KVYC@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S binding domain	-	-	-	ko:K07307	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3	-	-	Fer4_11,Fer4_4
k59_110404_1	1095769.CAHF01000015_gene2767	2.14e-33	135.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria	28216|Betaproteobacteria	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_860732_1	1500894.JQNN01000001_gene3570	3.17e-12	74.3	COG3115@1|root,COG3115@2|Bacteria,1QW35@1224|Proteobacteria,2WI64@28216|Betaproteobacteria,476RD@75682|Oxalobacteraceae	28216|Betaproteobacteria	D	cell septum assembly	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_926873_2	462590.A9J4Z3_BPPYU	2.01e-12	65.1	4QGKG@10239|Viruses,4QXQA@35237|dsDNA viruses  no RNA stage,4QQQR@28883|Caudovirales,4QMBG@10699|Siphoviridae	10699|Siphoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_175718_1	706587.Desti_2130	4.24e-45	152.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,43AV8@68525|delta/epsilon subdivisions,2X69B@28221|Deltaproteobacteria,2MSKC@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_175718_2	204669.Acid345_0821	6.23e-09	58.9	COG2202@1|root,COG4564@1|root,COG2202@2|Bacteria,COG4564@2|Bacteria	2|Bacteria	T	Single Cache domain 2	degS	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,PAS_3,sCache_2
k59_567670_1	926569.ANT_15910	8.77e-103	315.0	COG0481@1|root,COG0481@2|Bacteria,2G5K2@200795|Chloroflexi	200795|Chloroflexi	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_861894_1	1347368.HG964403_gene4701	1.24e-44	148.0	COG2204@1|root,COG2204@2|Bacteria,1UHXE@1239|Firmicutes,4ISDB@91061|Bacilli,1ZS5M@1386|Bacillus	91061|Bacilli	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
k59_928101_1	1121937.AUHJ01000003_gene3215	9.73e-54	172.0	2CVK5@1|root,32SXS@2|Bacteria,1N0ZG@1224|Proteobacteria,1S9R3@1236|Gammaproteobacteria,467R6@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_273214_1	365046.Rta_10290	4.31e-60	191.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VH4T@28216|Betaproteobacteria,4ACR9@80864|Comamonadaceae	28216|Betaproteobacteria	J	Belongs to the SUA5 family	yciO	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
k59_568909_1	1254432.SCE1572_47670	8.74e-05	43.9	COG3500@1|root,COG3500@2|Bacteria,1Q2U5@1224|Proteobacteria,42UA7@68525|delta/epsilon subdivisions,2WQM0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Late control gene D protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
k59_568909_2	1254432.SCE1572_47665	7.88e-70	217.0	COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,42Q1X@68525|delta/epsilon subdivisions,2WM75@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_928104_1	1286631.X805_35840	1.94e-53	174.0	COG2032@1|root,COG2032@2|Bacteria,1N26J@1224|Proteobacteria,2VT83@28216|Betaproteobacteria,1KMRI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
k59_372144_1	1537715.JQFJ01000005_gene8	6.07e-46	167.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,2K0VR@204457|Sphingomonadales	204457|Sphingomonadales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4,Toprim_N,zf-CHC2
k59_928107_1	1218076.BAYB01000012_gene2610	2.83e-16	79.0	COG1714@1|root,COG1714@2|Bacteria,1REEC@1224|Proteobacteria,2VRE0@28216|Betaproteobacteria,1K0CS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_79298_1	1122194.AUHU01000013_gene760	1.6e-06	50.4	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,4649A@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K02483,ko:K07660	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_239699_1	330214.NIDE3743	5.56e-133	394.0	COG1132@1|root,COG1132@2|Bacteria,3J0X8@40117|Nitrospirae	40117|Nitrospirae	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_960699_1	713586.KB900536_gene1177	5.84e-123	387.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_633668_1	1288494.EBAPG3_14260	6.07e-81	247.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,371PT@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_503714_1	1123326.JFBL01000001_gene1310	2.98e-31	120.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,42NVW@68525|delta/epsilon subdivisions,2YR6V@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Urea short-chain amide ABC transporter, periplasmic urea short-chain amide-binding protein	-	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
k59_209216_1	1379698.RBG1_1C00001G0297	3.03e-75	237.0	COG4881@1|root,COG4881@2|Bacteria	2|Bacteria	-	-	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_111629_1	1123024.AUII01000006_gene4644	2.28e-39	144.0	COG0654@1|root,COG0654@2|Bacteria,2GNA8@201174|Actinobacteria,4E77N@85010|Pseudonocardiales	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	1.14.13.10	ko:K19189	ko00760,ko01120,map00760,map01120	-	R04130	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,NAD_binding_8
k59_468191_1	748247.AZKH_p0003	1.47e-85	264.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VKUX@28216|Betaproteobacteria,2KY67@206389|Rhodocyclales	206389|Rhodocyclales	M	Alanine racemase, C-terminal domain	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_894086_1	198628.Dda3937_03501	2.77e-07	57.4	COG0840@1|root,COG0840@2|Bacteria,1PEDV@1224|Proteobacteria,1SK4H@1236|Gammaproteobacteria,2JCCG@204037|Dickeya	1236|Gammaproteobacteria	NT	Tar ligand binding domain homologue	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,TarH
k59_530952_1	1229909.NSED_09015	2.53e-130	390.0	COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_209221_1	177437.HRM2_44710	3.8e-72	232.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_144316_1	1217718.ALOU01000037_gene2027	6.85e-24	98.6	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHEF@28216|Betaproteobacteria,1KGVI@119060|Burkholderiaceae	28216|Betaproteobacteria	P	abc transporter	dppB2	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_144316_2	631454.N177_1686	2.65e-57	196.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,1JQ8Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_13975_1	112098.XP_008615047.1	3.41e-47	165.0	COG1960@1|root,KOG0141@2759|Eukaryota	2759|Eukaryota	I	isovaleryl-CoA dehydrogenase activity	IVD	GO:0000166,GO:0003674,GO:0003824,GO:0003853,GO:0003995,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006139,GO:0006163,GO:0006195,GO:0006520,GO:0006551,GO:0006552,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008470,GO:0009056,GO:0009058,GO:0009062,GO:0009063,GO:0009081,GO:0009083,GO:0009109,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0018130,GO:0019395,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033539,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034440,GO:0034641,GO:0034654,GO:0034655,GO:0035337,GO:0035383,GO:0035639,GO:0036094,GO:0036115,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0051259,GO:0051260,GO:0055086,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0072521,GO:0072523,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901568,GO:1901569,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902189,GO:1902190,GO:1902192,GO:1902195,GO:1902196,GO:1902198	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_928131_1	1437824.BN940_09851	1.33e-62	207.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,3T1IK@506|Alcaligenaceae	28216|Betaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_445162_2	1123368.AUIS01000007_gene2765	6.74e-46	164.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1SMM0@1236|Gammaproteobacteria,2NBR8@225057|Acidithiobacillales	225057|Acidithiobacillales	P	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_936346_1	472759.Nhal_0399	3.8e-68	218.0	COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,1RPIG@1236|Gammaproteobacteria,1WWW6@135613|Chromatiales	135613|Chromatiales	M	acid synthase	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
k59_184602_1	1348657.M622_01985	2.77e-103	313.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,2KU9B@206389|Rhodocyclales	206389|Rhodocyclales	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_641589_1	384765.SIAM614_02541	2.55e-14	74.3	COG1289@1|root,COG1289@2|Bacteria	2|Bacteria	S	transmembrane transporter activity	VPA1578	-	-	-	-	-	-	-	-	-	-	-	FUSC
k59_217048_1	1454004.AW11_00538	1.76e-56	194.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Major facilitator Superfamily	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	Acyltransferase,MFS_1
k59_936352_1	1163617.SCD_n00195	1.43e-35	128.0	2BWQ4@1|root,32QZV@2|Bacteria,1MZQ9@1224|Proteobacteria,2VSNR@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
k59_869956_1	243233.MCA2447	3.56e-118	363.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1XDRZ@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_609278_1	1411123.JQNH01000001_gene281	3.52e-29	110.0	COG0824@1|root,COG0824@2|Bacteria,1MZPN@1224|Proteobacteria	1224|Proteobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT,4HBT_2
k59_379784_1	365046.Rta_15900	1.74e-93	282.0	COG1995@1|root,COG1995@2|Bacteria,1MXGJ@1224|Proteobacteria,2VISV@28216|Betaproteobacteria,4ABVP@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the PdxA family	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_152379_1	85643.Tmz1t_1658	1.27e-182	528.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,2KVQH@206389|Rhodocyclales	206389|Rhodocyclales	I	Acetyl-coenzyme A synthetase N-terminus	acsA	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_675341_1	498848.TaqDRAFT_4992	2.69e-24	98.6	2B4TG@1|root,31XK1@2|Bacteria,1WJS0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_511848_1	477184.KYC_14537	9.87e-53	177.0	COG2242@1|root,COG2242@2|Bacteria,1R0I9@1224|Proteobacteria,2VRVM@28216|Betaproteobacteria,3T1H7@506|Alcaligenaceae	28216|Betaproteobacteria	H	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_936376_1	330214.NIDE0426	4.08e-102	312.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3J0CA@40117|Nitrospirae	40117|Nitrospirae	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_768951_1	1504672.669784874	1.25e-78	242.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2VP2D@28216|Betaproteobacteria,4AEEG@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_152392_1	1380394.JADL01000002_gene1317	3.22e-64	209.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,2JW50@204441|Rhodospirillales	204441|Rhodospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_474924_1	930166.CD58_27090	4.74e-49	159.0	COG4683@1|root,COG4683@2|Bacteria	2|Bacteria	K	PFAM Phage derived protein Gp49-like (DUF891)	VY92_07350	-	-	-	-	-	-	-	-	-	-	-	Gp49
k59_675356_1	1125863.JAFN01000001_gene1889	9.18e-26	114.0	COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria,42RIF@68525|delta/epsilon subdivisions,2WNC6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_534780_1	1042326.AZNV01000006_gene4528	3.5e-93	290.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2U1RU@28211|Alphaproteobacteria,4BB0R@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Predicted Permease Membrane Region	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
k59_869993_1	666681.M301_0012	4.62e-12	71.2	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,2KMBV@206350|Nitrosomonadales	206350|Nitrosomonadales	Q	Hemolysin-type calcium-binding region	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind
k59_184634_1	56780.SYN_02946	3.53e-48	169.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
k59_675363_1	5059.CADAFLAP00006257	0.000157	48.5	COG1215@1|root,2QVIM@2759|Eukaryota,39VBT@33154|Opisthokonta,3NZ6Q@4751|Fungi,3QNF4@4890|Ascomycota,20FIR@147545|Eurotiomycetes,3S4XC@5042|Eurotiales	4751|Fungi	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
k59_277237_1	1380394.JADL01000001_gene2351	3.68e-21	94.0	COG0730@1|root,COG0730@2|Bacteria,1PJR4@1224|Proteobacteria,2TU14@28211|Alphaproteobacteria,2JWE3@204441|Rhodospirillales	204441|Rhodospirillales	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
k59_379827_1	83406.HDN1F_32370	5.69e-35	136.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg,dCache_1
k59_313783_3	269796.Rru_A3008	0.000273	42.7	COG0727@1|root,COG0727@2|Bacteria,1N37X@1224|Proteobacteria,2U95A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_675372_1	1380391.JIAS01000012_gene4069	2.44e-98	317.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPMJ@204441|Rhodospirillales	204441|Rhodospirillales	V	COG0841 Cation multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1000370_1	344747.PM8797T_04710	9.12e-67	228.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2IXKD@203682|Planctomycetes	203682|Planctomycetes	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_609334_1	946483.Cenrod_0318	2.94e-36	135.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,4AAGK@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_609334_2	582744.Msip34_0531	5.2e-58	190.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,2KMGQ@206350|Nitrosomonadales	28216|Betaproteobacteria	C	Cytochrome bd terminal oxidase subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_313787_2	1121875.KB907553_gene20	2.97e-106	323.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_708151_1	748247.AZKH_4269	3.59e-72	224.0	COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VJQ5@28216|Betaproteobacteria,2KV0G@206389|Rhodocyclales	206389|Rhodocyclales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_511888_1	765913.ThidrDRAFT_3736	3.23e-32	114.0	2A7ME@1|root,30WJD@2|Bacteria,1P4YX@1224|Proteobacteria	765913.ThidrDRAFT_3736|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_511888_2	765913.ThidrDRAFT_1143	2.94e-128	372.0	COG3415@1|root,COG3415@2|Bacteria,1QWT2@1224|Proteobacteria,1T5A1@1236|Gammaproteobacteria,1X2VP@135613|Chromatiales	1236|Gammaproteobacteria	L	PFAM Transposase, Rhodopirellula-type	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
k59_409906_1	1167006.UWK_00225	1.04e-23	101.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,42P7C@68525|delta/epsilon subdivisions,2WKKF@28221|Deltaproteobacteria,2MIJE@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM MltA	-	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
k59_936423_1	1198232.CYCME_2286	2.67e-92	280.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,4604R@72273|Thiotrichales	72273|Thiotrichales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_676344_1	1134912.AJTV01000004_gene943	1.08e-33	129.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,36X99@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	MA20_05390	-	2.1.1.79	ko:K00574,ko:K18164	ko04714,map04714	-	-	-	ko00000,ko00001,ko01000,ko03029	-	-	-	Methyltransf_28
k59_839690_1	420662.Mpe_A2226	8.13e-87	265.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,1KKCN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	2-dehydropantoate 2-reductase	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_314629_1	395494.Galf_0302	3.45e-128	374.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,44VDS@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_610261_1	1125863.JAFN01000001_gene2427	7.45e-75	228.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,42MCM@68525|delta/epsilon subdivisions,2WKRE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_902557_1	1304885.AUEY01000001_gene3164	1.94e-28	119.0	COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MPMK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7,PAS_8,PAS_9,Response_reg,SBP_bac_3,sCache_3_2
k59_709154_1	313628.LNTAR_25000	5.54e-38	145.0	COG0188@1|root,COG0188@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363	5.99.1.3	ko:K02469,ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1001260_1	748658.KB907314_gene182	5.7e-12	66.2	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1001260_2	748247.AZKH_3236	1.67e-103	307.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,2KV71@206389|Rhodocyclales	206389|Rhodocyclales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_937400_1	1415775.U729_1318	4.03e-11	67.4	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,36E31@31979|Clostridiaceae	186801|Clostridia	K	UbiC transcription regulator-associated domain protein	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
k59_153413_1	1101195.Meth11DRAFT_1050	2.47e-17	77.8	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2VUM6@28216|Betaproteobacteria,2KMQW@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
k59_218010_1	1123320.KB889614_gene9675	4.87e-29	113.0	2BYTM@1|root,2Z7KC@2|Bacteria,2GJ6K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_937412_1	1229205.BUPH_02192	1.86e-51	176.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2VHD4@28216|Betaproteobacteria,1K15A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_839723_1	1353537.TP2_14815	1.63e-08	58.9	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2U72X@28211|Alphaproteobacteria,2XNE8@285107|Thioclava	28211|Alphaproteobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ptpA	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_902581_1	748247.AZKH_2820	2.91e-104	308.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,2KVHM@206389|Rhodocyclales	206389|Rhodocyclales	G	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_247450_1	66692.ABC0737	8.43e-07	55.8	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,4HASP@91061|Bacilli,1ZCSG@1386|Bacillus	91061|Bacilli	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_446179_1	765912.Thimo_0956	2.78e-07	52.4	COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,1RSI6@1236|Gammaproteobacteria,1X2EM@135613|Chromatiales	135613|Chromatiales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	ko:K13816	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001	-	-	-	ECH_1
k59_446179_2	1121015.N789_05890	0.000192	46.6	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_475769_1	1545915.JROG01000003_gene1383	8.23e-47	171.0	COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria,2K1SP@204457|Sphingomonadales	204457|Sphingomonadales	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
k59_380749_1	1342299.Z947_153	2.83e-18	89.4	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3ZXYH@60136|Sulfitobacter	28211|Alphaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_791677_1	1411123.JQNH01000001_gene1174	1.66e-98	296.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria	1224|Proteobacteria	T	radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_709207_1	1120983.KB894577_gene3578	1.08e-65	211.0	COG0673@1|root,COG0673@2|Bacteria,1PGFP@1224|Proteobacteria,2V8DN@28211|Alphaproteobacteria,1JQA3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_153452_1	671143.DAMO_0085	3.02e-137	398.0	COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria	2|Bacteria	E	Arginosuccinate synthase	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
k59_676423_1	1380391.JIAS01000012_gene4169	5.96e-06	47.8	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2U4KR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_348949_1	1121940.AUDZ01000005_gene1770	7.29e-67	213.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1XHW3@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_348949_2	1188252.AJYK01000057_gene326	2.9e-11	62.8	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1XSJE@135623|Vibrionales	135623|Vibrionales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_741627_1	945713.IALB_0005	1.2e-77	251.0	COG0187@1|root,COG0187@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_970124_1	243233.MCA1585	3.25e-85	276.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	isomerase	-	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_937467_1	381666.H16_B0977	1.93e-78	252.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,1K1CB@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_185546_1	497321.C664_10168	1.52e-78	260.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KVC4@206389|Rhodocyclales	206389|Rhodocyclales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_676433_1	864563.HMPREF9166_1588	3.42e-55	191.0	COG0471@1|root,COG0471@2|Bacteria,1TSP2@1239|Firmicutes,4H355@909932|Negativicutes	909932|Negativicutes	P	Transporter DASS family	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_871022_2	572477.Alvin_0616	1.95e-07	52.8	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,1RPQA@1236|Gammaproteobacteria,1WWXJ@135613|Chromatiales	135613|Chromatiales	S	PFAM ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
k59_1001321_1	1094715.CM001373_gene3323	1.13e-06	49.7	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1JC5V@118969|Legionellales	118969|Legionellales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_1001321_2	28229.ND2E_2955	8.54e-32	122.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,2Q646@267889|Colwelliaceae	1236|Gammaproteobacteria	C	Cytochrome c	cc4	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_61933_1	159087.Daro_0333	1.47e-69	212.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,2KWAI@206389|Rhodocyclales	206389|Rhodocyclales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_61933_2	1123487.KB892835_gene3654	1.88e-42	141.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,2KX1F@206389|Rhodocyclales	206389|Rhodocyclales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_61933_3	557598.LHK_00265	1.3e-95	281.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2VHCP@28216|Betaproteobacteria,2KPPI@206351|Neisseriales	206351|Neisseriales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_794459_1	330214.NIDE1094	1.84e-68	231.0	COG0577@1|root,COG0577@2|Bacteria,3J0Z3@40117|Nitrospirae	40117|Nitrospirae	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_96093_2	400668.Mmwyl1_0518	2.14e-66	218.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,1RRRD@1236|Gammaproteobacteria,1XNA5@135619|Oceanospirillales	135619|Oceanospirillales	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22186	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
k59_909619_1	1207063.P24_16355	1.09e-46	159.0	COG4177@1|root,COG4177@2|Bacteria,1PAW4@1224|Proteobacteria,2U0EY@28211|Alphaproteobacteria,2JZAV@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_909619_2	1207063.P24_16360	5.17e-39	137.0	COG0559@1|root,COG0559@2|Bacteria,1R5H9@1224|Proteobacteria,2TUJ6@28211|Alphaproteobacteria,2JVT7@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_847432_1	1238182.C882_0257	1.36e-68	232.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPRP@204441|Rhodospirillales	204441|Rhodospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_776499_1	1163408.UU9_11963	0.000623	42.4	COG0388@1|root,COG3153@1|root,COG0388@2|Bacteria,COG3153@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1X55P@135614|Xanthomonadales	135614|Xanthomonadales	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_776499_2	1132442.KB889754_gene55	1.47e-18	85.5	COG0454@1|root,COG0456@2|Bacteria,1U521@1239|Firmicutes,4HBEJ@91061|Bacilli,1ZCHR@1386|Bacillus	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	ykwB	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_909631_1	768706.Desor_3869	4.06e-53	182.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1566,FGE-sulfatase,Lactamase_B_2,PD40,Peptidase_S9
k59_878141_1	335543.Sfum_0593	1.65e-87	268.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42S7F@68525|delta/epsilon subdivisions,2WK0P@28221|Deltaproteobacteria,2MS10@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_794468_1	1283300.ATXB01000001_gene1602	7.04e-56	190.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XDNC@135618|Methylococcales	135618|Methylococcales	EH	synthase component I	pabB	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_417223_1	1249627.D779_0179	1.46e-11	61.6	2BK43@1|root,32EHP@2|Bacteria,1RDAC@1224|Proteobacteria,1S4CA@1236|Gammaproteobacteria,1WY9U@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_417223_2	1123393.KB891317_gene2441	3.26e-154	449.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria,1KSUD@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Fumarate reductase flavoprotein C-term	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_61961_1	1121396.KB892957_gene3252	1.74e-44	148.0	COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,42TER@68525|delta/epsilon subdivisions,2WPKW@28221|Deltaproteobacteria,2MK8J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Thioesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_61961_2	1550073.JROH01000004_gene2273	5.11e-42	145.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,2K0IR@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_649841_1	292415.Tbd_1148	3.59e-87	278.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,1KR9S@119069|Hydrogenophilales	119069|Hydrogenophilales	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3
k59_1008362_1	211114.JOEF01000020_gene788	4.34e-24	107.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2I12T@201174|Actinobacteria,4DX7Y@85010|Pseudonocardiales	201174|Actinobacteria	L	UvrD/REP helicase N-terminal domain	pcrA	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
k59_1008364_1	335543.Sfum_1393	1.08e-45	156.0	COG0483@1|root,COG0483@2|Bacteria,1NVDS@1224|Proteobacteria,42ZN3@68525|delta/epsilon subdivisions,2WUWR@28221|Deltaproteobacteria,2MRNA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_225119_1	472759.Nhal_1492	3.69e-73	242.0	COG1262@1|root,COG1672@1|root,COG1262@2|Bacteria,COG1672@2|Bacteria,1RAMU@1224|Proteobacteria,1S87Q@1236|Gammaproteobacteria,1X2AR@135613|Chromatiales	135613|Chromatiales	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
k59_977775_1	484770.UFO1_3078	5.19e-10	59.3	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,4H32H@909932|Negativicutes	909932|Negativicutes	EJ	Belongs to the asparaginase 1 family	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_977775_2	682795.AciX8_3564	2.05e-21	98.6	COG0845@1|root,COG0845@2|Bacteria,3Y45V@57723|Acidobacteria,2JIPU@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18298,ko:K19586	-	M00641,M00767	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.47,8.A.1	-	-	HlyD_D23
k59_716752_1	338963.Pcar_1951	6.3e-23	97.8	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria,43U48@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Ferrous iron transport protein B C terminus	feoB-1	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_848488_2	640081.Dsui_2265	1.26e-56	199.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,2KUNR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
k59_777441_1	1121405.dsmv_0363	4.85e-69	216.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MHZU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_357358_1	1538295.JY96_07450	7.78e-100	303.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,1KJ9Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CI	Bifunctional enoyl-CoA hydratase phosphate acetyltransferase	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_97141_1	1120966.AUBU01000006_gene3208	5.25e-89	278.0	2BQG9@1|root,32JBP@2|Bacteria,4NREU@976|Bacteroidetes,47URQ@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_717732_1	1191523.MROS_2563	1.41e-17	85.5	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	fadL	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_717732_2	1121920.AUAU01000013_gene1695	2.57e-16	79.3	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,3Y2WK@57723|Acidobacteria	57723|Acidobacteria	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1
k59_62944_1	1255043.TVNIR_1942	1.83e-09	56.6	COG0695@1|root,COG0695@2|Bacteria,1N0IY@1224|Proteobacteria,1SA4G@1236|Gammaproteobacteria,1X11H@135613|Chromatiales	135613|Chromatiales	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_N_3
k59_62944_2	1328313.DS2_19366	5.79e-81	243.0	COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,1RR6R@1236|Gammaproteobacteria,467HT@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
k59_97143_1	1219084.AP014508_gene1812	2.69e-37	139.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_97143_2	641491.DND132_2395	7.79e-09	56.2	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MAH4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_618533_1	1079460.ATTQ01000001_gene5464	1.27e-72	236.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_418193_1	1437882.AZRU01000013_gene6902	6.58e-05	42.7	COG3063@1|root,COG3063@2|Bacteria,1N2T8@1224|Proteobacteria,1S9R8@1236|Gammaproteobacteria,1YGFC@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2
k59_418193_2	1452718.JBOY01000023_gene328	6.58e-57	201.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	morA	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,dCache_2
k59_388675_1	1121373.KB903664_gene2658	1.15e-22	97.4	28N4A@1|root,2ZB9T@2|Bacteria,4NS50@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
k59_254869_1	1215092.PA6_017_01400	5.65e-07	52.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1YF2V@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	O	AAA domain	IV02_30220	-	-	ko:K04770	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_254869_2	1385512.N784_06850	2.75e-36	130.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,4HCEX@91061|Bacilli,2YA2T@289201|Pontibacillus	91061|Bacilli	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06365	CDP-OH_P_transf
k59_750379_1	570967.JMLV01000006_gene189	2.42e-58	194.0	2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2TTH2@28211|Alphaproteobacteria,2JR3R@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_650808_1	631362.Thi970DRAFT_04215	1.06e-82	251.0	COG3751@1|root,COG3751@2|Bacteria,1RBXB@1224|Proteobacteria,1RR8W@1236|Gammaproteobacteria,1WWUG@135613|Chromatiales	135613|Chromatiales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
k59_650808_2	2340.JV46_02620	6.75e-05	45.4	COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,1JA3Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Prolyl 4-hydroxylase alpha subunit homologues.	ybiX	-	-	ko:K07336	-	-	-	-	ko00000,ko01000	-	-	-	2OG-FeII_Oxy_3
k59_193784_1	290397.Adeh_0637	2.84e-46	161.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2YVME@29|Myxococcales	28221|Deltaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_388677_1	30611.ENSOGAP00000010579	4.67e-11	69.3	KOG1217@1|root,KOG4297@1|root,KOG1217@2759|Eukaryota,KOG4297@2759|Eukaryota,38B50@33154|Opisthokonta,3BCEG@33208|Metazoa,3CRUF@33213|Bilateria,489FW@7711|Chordata,4955D@7742|Vertebrata,3J9N9@40674|Mammalia,35MGR@314146|Euarchontoglires,4MEHI@9443|Primates	33208|Metazoa	T	Sushi, von Willebrand factor type A, EGF and pentraxin	SVEP1	GO:0003674,GO:0003682,GO:0005488,GO:0005575,GO:0005576	-	ko:K17495	-	-	-	-	ko00000,ko01009	-	-	-	EGF,EGF_2,EGF_CA,Ephrin_rec_like,HYR,Pentaxin,Sushi,VWA,hEGF
k59_879134_1	640081.Dsui_1583	2.3e-168	483.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,2KU8D@206389|Rhodocyclales	1224|Proteobacteria	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_879134_2	264198.Reut_B5828	5.46e-37	139.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,1K0AQ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	methylmalonate-semialdehyde dehydrogenase	mmsA_2	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_946035_1	1123054.KB907725_gene3182	3.06e-40	143.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,1RNMT@1236|Gammaproteobacteria,1WXIM@135613|Chromatiales	135613|Chromatiales	P	PFAM Ion transport	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
k59_777455_1	706587.Desti_2948	1.29e-31	122.0	COG0069@1|root,COG0069@2|Bacteria	2|Bacteria	E	glutamate synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Glu_synthase
k59_777455_2	1232437.KL661971_gene4887	2.51e-27	112.0	COG0069@1|root,COG1143@1|root,COG0069@2|Bacteria,COG1143@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria,2MHXF@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Glu_synthase
k59_161611_1	864051.BurJ1DRAFT_1757	9.3e-83	262.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,1KJF5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_62957_1	1123255.JHYS01000015_gene1123	1.24e-11	65.1	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,4AAMH@80864|Comamonadaceae	28216|Betaproteobacteria	J	TIGRFAM glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_62957_2	1288494.EBAPG3_23450	4.82e-47	162.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,2VNXD@28216|Betaproteobacteria,3721Q@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_1009322_1	436308.Nmar_0065	1.13e-98	295.0	COG2219@1|root,arCOG03013@2157|Archaea,41SCD@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
k59_282269_1	1247649.D560_3828	2.27e-91	276.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2VN7F@28216|Betaproteobacteria,3T7ZU@506|Alcaligenaceae	28216|Betaproteobacteria	L	Transposase for IS481 element	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
k59_946039_1	926550.CLDAP_00560	2.09e-52	188.0	COG2373@1|root,COG2373@2|Bacteria,2G5XN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1
k59_62958_2	580332.Slit_1849	8e-36	129.0	COG0810@1|root,COG0810@2|Bacteria,1MZQW@1224|Proteobacteria,2VU0N@28216|Betaproteobacteria,44W0B@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
k59_226111_1	270374.MELB17_22515	1.69e-38	142.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1T7KM@1236|Gammaproteobacteria,46C37@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_848518_1	1442599.JAAN01000024_gene1996	2.88e-65	222.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1X527@135614|Xanthomonadales	135614|Xanthomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_418210_1	572477.Alvin_1281	7.44e-51	172.0	COG0608@1|root,COG0608@2|Bacteria,1N37P@1224|Proteobacteria,1RQTR@1236|Gammaproteobacteria,1WWFV@135613|Chromatiales	135613|Chromatiales	L	single-stranded DNA 5'-3' exodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_161617_1	592028.GCWU000321_01699	4.08e-05	53.1	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,4H1YF@909932|Negativicutes	909932|Negativicutes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_777471_1	436308.Nmar_0037	2.22e-34	124.0	COG0602@1|root,arCOG02173@2157|Archaea,41SGM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Radical_SAM
k59_777471_2	1229909.NSED_09815	7.1e-20	84.0	COG0302@1|root,arCOG04542@2157|Archaea,41SGC@651137|Thaumarchaeota	651137|Thaumarchaeota	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_1027383_1	1238182.C882_0107	7.12e-79	257.0	COG3221@1|root,COG4191@1|root,COG3221@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2JQBZ@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	dctS	-	2.7.13.3	ko:K11711	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,Phosphonate-bd
k59_910647_1	1353537.TP2_15025	3.6e-82	249.0	COG2102@1|root,COG2102@2|Bacteria,1MUU2@1224|Proteobacteria,2U3M8@28211|Alphaproteobacteria,2XM1U@285107|Thioclava	28211|Alphaproteobacteria	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
k59_794912_1	1287276.X752_25460	1.61e-26	107.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,43GQV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_794912_2	1415756.JQMY01000001_gene1253	1.6e-10	61.6	COG0697@1|root,COG0697@2|Bacteria,1P3V0@1224|Proteobacteria,2TQJK@28211|Alphaproteobacteria,2PCMM@252301|Oceanicola	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_685143_1	76114.ebA1314	9.23e-51	180.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KUCM@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_777476_1	1167006.UWK_02426	9.52e-52	171.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,42NJR@68525|delta/epsilon subdivisions,2WKAM@28221|Deltaproteobacteria,2MJHK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k59_777476_2	159087.Daro_2284	2.49e-42	140.0	COG2963@1|root,COG2963@2|Bacteria,1N06K@1224|Proteobacteria,2VUF3@28216|Betaproteobacteria,2KZ7Q@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_62978_1	1095769.CAHF01000022_gene365	6.75e-36	132.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2VIUU@28216|Betaproteobacteria,478NG@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
k59_62978_2	1500259.JQLD01000010_gene4819	7.16e-25	105.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2U8QU@28211|Alphaproteobacteria,4BJA0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_777477_1	436308.Nmar_1414	1.06e-24	97.4	arCOG08774@1|root,arCOG08774@2157|Archaea,41T7U@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_777477_2	436308.Nmar_1415	4.71e-33	123.0	COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
k59_1027388_1	913865.DOT_2410	7.33e-07	47.8	COG1146@1|root,COG1146@2|Bacteria,1VETY@1239|Firmicutes,25E51@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
k59_1027388_2	443143.GM18_2311	2.32e-58	186.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,42SIR@68525|delta/epsilon subdivisions,2WPJY@28221|Deltaproteobacteria,43V2X@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k59_357415_1	388051.AUFE01000108_gene4336	2.3e-40	141.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2VQ2D@28216|Betaproteobacteria,1K0VZ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Peptidase M19	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_521690_1	187303.BN69_3653	1.61e-43	160.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,36XPJ@31993|Methylocystaceae	28211|Alphaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_521690_2	1121127.JAFA01000006_gene5681	4.91e-30	118.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
k59_794913_2	6412.HelroP172394	2.73e-31	123.0	2BNS1@1|root,2S1Q7@2759|Eukaryota,3A48Y@33154|Opisthokonta,3CP8W@33208|Metazoa,3E5DG@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1009354_1	96561.Dole_3001	2.42e-28	117.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,42QTW@68525|delta/epsilon subdivisions,2WMNU@28221|Deltaproteobacteria,2MJYF@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K02445	-	-	-	-	ko00000,ko02000	2.A.1.4.3	-	-	MFS_1
k59_917492_1	272123.Anacy_4176	2.77e-34	136.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG3437@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,COG3437@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_884295_1	714083.JH370377_gene1618	1.41e-18	84.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4FKNS@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_884295_2	62928.azo3487	7.08e-34	124.0	COG0746@1|root,COG0746@2|Bacteria,1QVCV@1224|Proteobacteria,2WGQQ@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Protein of unknown function (DUF3305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3305
k59_623518_1	335543.Sfum_2673	1.63e-18	84.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
k59_623518_2	159087.Daro_3577	3.64e-27	108.0	COG1638@1|root,COG1638@2|Bacteria,1PMWE@1224|Proteobacteria,2VNJI@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_133842_1	991905.SL003B_3211	8.96e-107	313.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,4BRCM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase, mono-heme subunit/FixO	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_427442_1	1500897.JQNA01000002_gene147	5.59e-71	224.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,1K2G7@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	cysA2	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_427442_2	381666.H16_B1950	1.92e-36	133.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2VKTZ@28216|Betaproteobacteria,1K02I@119060|Burkholderiaceae	28216|Betaproteobacteria	P	transporter	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_851835_1	1458275.AZ34_11740	1.44e-115	339.0	COG0687@1|root,COG0687@2|Bacteria,1NKD7@1224|Proteobacteria,2WFDT@28216|Betaproteobacteria,4AJSA@80864|Comamonadaceae	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
k59_296822_1	1307761.L21SP2_2089	1.17e-52	186.0	COG3666@1|root,COG3666@2|Bacteria,2J98U@203691|Spirochaetes	203691|Spirochaetes	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_590874_1	1031711.RSPO_c01293	8.74e-38	139.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,1K01J@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN2	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_590874_2	257310.BB0510	3.27e-55	179.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,3T1QF@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_525575_1	483219.LILAB_22600	2.39e-29	121.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,CarbopepD_reg_2,Plug
k59_623525_1	933262.AXAM01000004_gene2356	6.45e-34	134.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MICZ@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2,PPDK_N
k59_101144_1	319003.Bra1253DRAFT_06208	2.53e-50	176.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria,3JVYJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_851836_1	264462.Bd0660	2.84e-52	177.0	2BI6Q@1|root,32CBY@2|Bacteria,1MYDT@1224|Proteobacteria,42T3X@68525|delta/epsilon subdivisions,2MTZ4@213481|Bdellovibrionales,2WPSM@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Protein of unknown function (DUF2914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2914
k59_688982_1	1124780.ANNU01000080_gene2581	4.04e-181	516.0	COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,47JYB@768503|Cytophagia	976|Bacteroidetes	L	PFAM Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_590888_1	1192868.CAIU01000003_gene374	4.29e-55	189.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,43GR9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k59_623541_1	1229205.BUPH_00851	1.91e-09	55.5	COG3832@1|root,COG3832@2|Bacteria,1RCZK@1224|Proteobacteria,2VR7G@28216|Betaproteobacteria,1K1RE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_623541_2	1038867.AXAY01000005_gene7223	5.83e-14	72.4	2E8II@1|root,332WK@2|Bacteria,1RAN8@1224|Proteobacteria,2U5M9@28211|Alphaproteobacteria,3JY9P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_427461_2	28072.Nos7524_2399	5.44e-29	109.0	COG3744@1|root,COG3744@2|Bacteria,1G5SF@1117|Cyanobacteria,1HNK3@1161|Nostocales	1117|Cyanobacteria	S	PFAM PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_493108_1	926550.CLDAP_08580	2.02e-46	154.0	COG3415@1|root,COG3415@2|Bacteria,2G91K@200795|Chloroflexi	200795|Chloroflexi	L	SPTR B0JRC2 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_493108_2	1469607.KK073768_gene3310	4.18e-81	247.0	COG3335@1|root,COG3335@2|Bacteria,1G5W5@1117|Cyanobacteria,1HSB3@1161|Nostocales	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_264440_1	323848.Nmul_A0214	1.97e-112	333.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,372CZ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_296843_1	1007105.PT7_0805	2.33e-93	285.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,3T1SD@506|Alcaligenaceae	28216|Betaproteobacteria	G	C4-dicarboxylate ABC transporter permease	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_688998_1	1121396.KB893095_gene4377	6.2e-71	227.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2MI9P@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_296844_1	867903.ThesuDRAFT_01618	2.33e-85	267.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia	186801|Clostridia	I	PFAM Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_525589_1	1535422.ND16A_2692	1.23e-16	81.3	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,2Q646@267889|Colwelliaceae	1236|Gammaproteobacteria	C	Cytochrome c	cc4	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_525589_2	398525.KB900701_gene1624	1.85e-16	85.1	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,2TSFV@28211|Alphaproteobacteria,3JRR1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_525589_3	589924.Ferp_0646	2.39e-59	202.0	COG5557@1|root,arCOG02025@2157|Archaea,2XWFI@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_68646_1	1121382.JQKG01000019_gene1267	1.55e-76	238.0	COG0411@1|root,COG0411@2|Bacteria,1WJG8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_917543_1	1128421.JAGA01000003_gene3230	6.96e-94	303.0	COG0567@1|root,COG0567@2|Bacteria,2NQJV@2323|unclassified Bacteria	2|Bacteria	C	Dehydrogenase E1 component	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_884339_1	1157708.KB907455_gene3218	1.99e-67	221.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4AGCN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_819636_1	395494.Galf_1772	1.36e-82	252.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,44VAM@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_851875_1	553217.ENHAE0001_0833	1.74e-14	79.3	COG1132@1|root,COG1132@2|Bacteria,1MXC2@1224|Proteobacteria,1RZQR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
k59_689012_1	379066.GAU_1541	1.57e-08	56.2	COG2018@1|root,COG2018@2|Bacteria,1ZU1J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
k59_101190_1	338969.Rfer_2852	1.04e-114	340.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	cytC6	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,EB_dh
k59_3200_1	1232437.KL662022_gene866	9.08e-102	323.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2MINC@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_166505_2	502025.Hoch_1898	1.71e-14	72.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,42WB9@68525|delta/epsilon subdivisions,2WSSJ@28221|Deltaproteobacteria,2YVJB@29|Myxococcales	28221|Deltaproteobacteria	S	PHB/PHA accumulation regulator DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc_N
k59_590924_1	338963.Pcar_0695	8.31e-26	105.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,43S5H@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	RNA polymerase I subunit A N-terminus	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_590924_2	1232410.KI421428_gene1223	5.55e-84	276.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,43SCN@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	RNA polymerase beta subunit external 1 domain	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_296868_1	690850.Desaf_2136	3.96e-37	138.0	COG1152@1|root,COG1152@2|Bacteria,1QX31@1224|Proteobacteria,42YU9@68525|delta/epsilon subdivisions,2WU35@28221|Deltaproteobacteria,2M8PD@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_525612_1	78245.Xaut_4562	1.62e-30	119.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,3F15K@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_525612_2	580332.Slit_0983	1.88e-92	283.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,44V9A@713636|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM peptidase S11 D-alanyl-D-alanine carboxypeptidase 1	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_721542_1	1211844.CBLM010000024_gene2206	3.27e-27	110.0	2C6CR@1|root,2Z7X4@2|Bacteria,1UY2Y@1239|Firmicutes,3VQD5@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Putative, 10TM heavy-metal exporter	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_2
k59_623575_1	1296416.JACB01000044_gene4945	9.06e-44	149.0	COG3576@1|root,COG3576@2|Bacteria,4NSA3@976|Bacteroidetes,1I8JI@117743|Flavobacteriia,2YJMK@290174|Aquimarina	976|Bacteroidetes	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_199165_1	479434.Sthe_2163	7.27e-54	177.0	COG0437@1|root,COG0437@2|Bacteria,2G6C1@200795|Chloroflexi,27XMT@189775|Thermomicrobia	189775|Thermomicrobia	C	4Fe-4S binding domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
k59_296873_1	1266925.JHVX01000016_gene191	3.41e-12	65.5	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,3724X@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_296873_2	1144319.PMI16_02307	2.69e-46	155.0	COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria,473TQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	signal sequence binding	sco1	-	-	-	-	-	-	-	-	-	-	-	-
k59_949987_2	399742.Ent638_1027	3.73e-11	63.2	COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,1RRB6@1236|Gammaproteobacteria,3X3RI@547|Enterobacter	1236|Gammaproteobacteria	S	Predicted Peptidoglycan domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_108,PG_binding_3
k59_101215_1	1380394.JADL01000002_gene1318	3.14e-102	305.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TT8C@28211|Alphaproteobacteria,2JW97@204441|Rhodospirillales	204441|Rhodospirillales	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_329662_1	1125863.JAFN01000001_gene3005	1.05e-58	192.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria	1224|Proteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_982382_1	330214.NIDE4188	8.71e-87	278.0	28J7E@1|root,2Z92U@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
k59_884377_1	521096.Tpau_2720	3.06e-15	73.2	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria	201174|Actinobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
k59_656391_1	105559.Nwat_2280	1.57e-37	143.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_689060_1	1500301.JQMF01000024_gene2018	1.7e-26	110.0	28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,2TSDQ@28211|Alphaproteobacteria,4B8RI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
k59_1013411_1	748658.KB907321_gene853	1.04e-41	139.0	COG3093@1|root,COG3093@2|Bacteria,1N2BD@1224|Proteobacteria,1S8Z4@1236|Gammaproteobacteria,1WZ50@135613|Chromatiales	135613|Chromatiales	K	TIGRFAM Addiction module antidote protein, HigA	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
k59_1013411_2	232346.JHQL01000001_gene2398	3.91e-49	157.0	COG3549@1|root,COG3549@2|Bacteria,1MZ4I@1224|Proteobacteria,1S9CP@1236|Gammaproteobacteria,1XKM7@135619|Oceanospirillales	135619|Oceanospirillales	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
k59_493187_1	754476.Q7A_2176	9.89e-27	102.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,460KD@72273|Thiotrichales	72273|Thiotrichales	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_493187_2	243233.MCA2792	2.18e-12	68.6	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1XDPV@135618|Methylococcales	135618|Methylococcales	Q	MlaC protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_362194_1	436308.Nmar_0730	1.97e-52	181.0	arCOG08764@1|root,arCOG08798@2157|Archaea,41SZ3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_264523_1	292415.Tbd_1456	9.81e-44	162.0	COG2202@1|root,COG5000@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KREN@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_3,PAS_4,dCache_1
k59_721579_1	78245.Xaut_0634	7.64e-14	70.1	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,3EYHQ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Guanylate_cyc,Response_reg,Trans_reg_C
k59_721579_2	1254432.SCE1572_04160	9.73e-22	100.0	COG0642@1|root,COG3437@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,HisKA_3,PAS,PAS_4,PAS_8,PAS_9,Response_reg,STAS
k59_558457_1	1454004.AW11_03201	2.88e-51	186.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_753633_1	477228.YO5_03602	3.88e-107	323.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1Z0MP@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_1778,iPC815.YPO3335	Fumerase,Fumerase_C
k59_35985_1	207954.MED92_03348	7.86e-36	134.0	COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,1S2ZY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM HupH hydrogenase expression protein, C-terminal conserved region	hyaF	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C,Rubredoxin
k59_329692_1	420662.Mpe_A0521	7.9e-15	74.7	2E58M@1|root,33011@2|Bacteria,1NFX1@1224|Proteobacteria,2VWUP@28216|Betaproteobacteria,1KMKA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_329692_2	1265502.KB905938_gene2507	2.53e-27	101.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2VSCX@28216|Betaproteobacteria,4AEI1@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
k59_101249_1	1254432.SCE1572_42550	3.64e-54	187.0	COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42PWB@68525|delta/epsilon subdivisions,2X5K5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM phosphoenolpyruvate phosphomutase	-	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,NTP_transf_3,PEP_mutase
k59_362211_1	1265502.KB905970_gene1296	1.21e-12	69.7	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,4ACPD@80864|Comamonadaceae	28216|Betaproteobacteria	G	Trap dicarboxylate transporter, dctm subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_623629_1	1121439.dsat_2567	2.9e-51	166.0	COG2204@1|root,COG2204@2|Bacteria,1RHEG@1224|Proteobacteria,42T1C@68525|delta/epsilon subdivisions,2WP30@28221|Deltaproteobacteria,2MBB7@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_232515_1	439235.Dalk_5087	4.54e-127	372.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_200467_1	330214.NIDE1156	2.11e-81	247.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ2	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_885650_1	1236959.BAMT01000005_gene97	2.56e-90	283.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,2KKEY@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_885650_2	497321.C664_10118	9.76e-83	252.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria,2KW2B@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_506404_1	933262.AXAM01000034_gene1578	6.9e-61	198.0	28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,43DCS@68525|delta/epsilon subdivisions,2X8IT@28221|Deltaproteobacteria,2MK0X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
k59_241969_1	1227739.Hsw_3277	3.24e-09	63.5	COG2885@1|root,COG2885@2|Bacteria,4NE8J@976|Bacteroidetes,47PTE@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA,TSP_3
k59_603952_2	1396418.BATQ01000038_gene5752	1.92e-31	125.0	28HPK@1|root,2Z7XJ@2|Bacteria,46VI6@74201|Verrucomicrobia,2IVHI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Bacteriophage head to tail connecting protein	-	-	-	-	-	-	-	-	-	-	-	-	Head-tail_con
k59_896642_1	582744.Msip34_2612	4.09e-19	88.6	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,2KMI1@206350|Nitrosomonadales	206350|Nitrosomonadales	M	PFAM AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_896642_2	1158292.JPOE01000002_gene3716	2.22e-50	168.0	2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,2VJKN@28216|Betaproteobacteria,1KKAR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	5'-nucleotidase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5-nucleotidase
k59_179561_1	66692.ABC2762	8.82e-22	94.0	COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,4HD12@91061|Bacilli,1ZBNZ@1386|Bacillus	91061|Bacilli	S	Acetoin utilization protein AcuB	acuB	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
k59_506418_1	987059.RBXJA2T_04058	2.15e-93	301.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,1KJV9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_669804_1	675813.VIB_002483	5.57e-114	347.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1XSIF@135623|Vibrionales	135623|Vibrionales	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_308923_1	1283299.AUKG01000001_gene1412	1.85e-95	301.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_16680_1	90813.JQMT01000001_gene658	4.32e-25	102.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,4602C@72273|Thiotrichales	72273|Thiotrichales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_669806_1	1189612.A33Q_3307	4.38e-110	340.0	COG1523@1|root,COG1523@2|Bacteria,4NIH2@976|Bacteroidetes,47KIY@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.41,3.2.1.68	ko:K01200,ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_211861_1	909663.KI867150_gene1321	2.77e-50	172.0	COG0500@1|root,COG1846@1|root,COG1846@2|Bacteria,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,43BRY@68525|delta/epsilon subdivisions,2X72R@28221|Deltaproteobacteria,2MQCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	KQ	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
k59_16682_1	1123508.JH636441_gene3522	2.78e-74	230.0	COG3293@1|root,COG3293@2|Bacteria,2IYHS@203682|Planctomycetes	203682|Planctomycetes	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_470382_1	1304872.JAGC01000003_gene3888	4.15e-56	191.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,42MHN@68525|delta/epsilon subdivisions,2WJU0@28221|Deltaproteobacteria,2M939@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_440055_1	426114.THI_3126	4.55e-09	57.4	COG0642@1|root,COG0642@2|Bacteria,1PA1G@1224|Proteobacteria,2VHX5@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	HAMP,HATPase_c,HisKA
k59_440055_2	426114.THI_3125	1.13e-64	203.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria,1KNJ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_211874_2	582744.Msip34_1541	5.98e-28	107.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2VUM6@28216|Betaproteobacteria,2KMQW@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
k59_274599_1	1266925.JHVX01000004_gene1169	7.08e-44	160.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,371VM@32003|Nitrosomonadales	28216|Betaproteobacteria	T	SMART Diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,Response_reg
k59_374792_1	381666.H16_A1816	2.84e-17	77.4	COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,2VU9I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_374792_2	1380394.JADL01000002_gene1605	3.86e-63	202.0	COG1028@1|root,COG1028@2|Bacteria,1Q7EW@1224|Proteobacteria,2TSMG@28211|Alphaproteobacteria,2JQ2V@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_864662_1	1121405.dsmv_2721	2.57e-138	400.0	COG0067@1|root,COG0067@2|Bacteria,1MW6C@1224|Proteobacteria,42MTE@68525|delta/epsilon subdivisions,2WJ9E@28221|Deltaproteobacteria,2MI1S@213118|Desulfobacterales	28221|Deltaproteobacteria	E	glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_636441_1	472759.Nhal_2490	6.69e-93	290.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_308952_1	1121035.AUCH01000013_gene3163	9.01e-93	298.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales	206389|Rhodocyclales	CM	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_342679_1	1504672.669784064	3.09e-59	196.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_930950_2	1169143.KB911038_gene6150	1.09e-108	322.0	COG3836@1|root,COG3836@2|Bacteria,1RCR7@1224|Proteobacteria,2WF9B@28216|Betaproteobacteria,1KCUA@119060|Burkholderiaceae	28216|Betaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_930950_3	1163617.SCD_n01900	3.21e-05	45.1	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria	28216|Betaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_789066_1	706587.Desti_4886	3.07e-52	178.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria,2MQUU@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_82102_2	759362.KVU_1087	4.57e-28	106.0	COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,2U9DU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_374811_1	926569.ANT_08690	4.64e-46	164.0	COG5624@1|root,COG5624@2|Bacteria,2G94N@200795|Chloroflexi	200795|Chloroflexi	K	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_242017_1	1042163.BRLA_c016200	1.5e-05	50.8	COG1266@1|root,COG1266@2|Bacteria,1V416@1239|Firmicutes,4HRGM@91061|Bacilli,2712B@186822|Paenibacillaceae	91061|Bacilli	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_16726_1	883126.HMPREF9710_04813	6.15e-07	56.2	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2VIK2@28216|Betaproteobacteria,473ZR@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_864686_1	1380390.JIAT01000010_gene4326	9.15e-75	240.0	COG1229@1|root,COG1229@2|Bacteria	2|Bacteria	C	Formylmethanofuran dehydrogenase subunit A	fhcA	GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0044237,GO:0044281	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
k59_571762_1	1229205.BUPH_05899	1.26e-118	355.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria,1KHV1@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_669854_1	1452718.JBOY01000151_gene3364	3.48e-60	202.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_669863_1	314345.SPV1_12415	3.82e-75	242.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria	1224|Proteobacteria	M	mechanosensitive ion channel	aefA	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_930978_1	748247.AZKH_3476	9.03e-18	80.9	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,2VU1H@28216|Betaproteobacteria,2KXAN@206389|Rhodocyclales	206389|Rhodocyclales	C	Dihaem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
k59_930978_2	1268622.AVS7_03484	8.35e-21	88.2	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,4AJRM@80864|Comamonadaceae	28216|Betaproteobacteria	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	qseB	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_532302_1	395495.Lcho_2099	1.76e-25	102.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,1KJJK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_532302_2	987059.RBXJA2T_15173	1.27e-166	469.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJU2@28216|Betaproteobacteria,1KIWQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the arginase family	rocF	-	3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7	ko:K01476,ko:K01480,ko:K12255,ko:K18459	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157,R01990	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_604033_2	204669.Acid345_1765	1.92e-26	101.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria,2JJH2@204432|Acidobacteriia	204432|Acidobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
k59_604033_3	1142394.PSMK_14500	1.74e-25	102.0	COG2172@1|root,COG2172@2|Bacteria,2J0BZ@203682|Planctomycetes	203682|Planctomycetes	T	COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
k59_833232_1	330214.NIDE3350	1.66e-61	190.0	COG2010@1|root,COG2010@2|Bacteria,3J17C@40117|Nitrospirae	2|Bacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cytochrome_CBB3
k59_833232_2	330214.NIDE3349	7.55e-22	95.9	COG4249@1|root,COG4249@2|Bacteria,3J0QX@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Peptidase_C14
k59_147140_1	1038859.AXAU01000001_gene3517	1.43e-11	70.5	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1,SAM_2
k59_532303_1	344747.PM8797T_04870	1.25e-36	135.0	COG1562@1|root,COG1562@2|Bacteria,2IXUP@203682|Planctomycetes	203682|Planctomycetes	I	Squalene phytoene synthase	-	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
k59_274626_1	1120972.AUMH01000011_gene146	3.29e-13	73.2	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,4HBJD@91061|Bacilli,27962@186823|Alicyclobacillaceae	91061|Bacilli	E	Membrane dipeptidase (Peptidase family M19)	dp2	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_963560_1	1569209.BBPH01000084_gene1939	0.000113	45.4	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TTSX@28211|Alphaproteobacteria,2PWKJ@265|Paracoccus	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_963560_2	864069.MicloDRAFT_00034970	3.34e-64	200.0	COG0625@1|root,COG0625@2|Bacteria,1N8XH@1224|Proteobacteria,2TTHQ@28211|Alphaproteobacteria,1JQQ2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	MA20_08585	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3
k59_637531_1	269799.Gmet_3176	2.29e-67	215.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2WKT8@28221|Deltaproteobacteria,43S3R@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
k59_375946_1	755178.Cyan10605_3351	1.47e-72	229.0	COG3049@1|root,COG3049@2|Bacteria,1G3YJ@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
k59_996305_1	76114.ebA6526	2.93e-80	260.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_50042_1	1458357.BG58_04440	1.28e-23	94.7	COG4731@1|root,COG4731@2|Bacteria,1N19Y@1224|Proteobacteria,2VS9I@28216|Betaproteobacteria,1K3ZJ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
k59_50042_2	1276756.AUEX01000017_gene3637	3.06e-46	165.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,4AAU6@80864|Comamonadaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_115557_1	234267.Acid_5892	2.13e-90	281.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
k59_471429_1	522306.CAP2UW1_0051	1.19e-74	238.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,1KQ9R@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Putative NAD(P)-binding	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_441230_2	1454004.AW11_00199	3.96e-138	397.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2VV9Q@28216|Betaproteobacteria,1KR1Z@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_343861_1	240015.ACP_1811	1.54e-90	280.0	COG4799@1|root,COG4799@2|Bacteria,3Y3SM@57723|Acidobacteria,2JIBH@204432|Acidobacteriia	204432|Acidobacteriia	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_865897_1	670307.HYPDE_34178	2.26e-62	196.0	COG1432@1|root,COG1432@2|Bacteria,1MUAE@1224|Proteobacteria,2TU5M@28211|Alphaproteobacteria,3N6N3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	MA20_36560	-	-	-	-	-	-	-	-	-	-	-	NYN
k59_406308_1	765911.Thivi_4498	7.29e-71	232.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,1RPQA@1236|Gammaproteobacteria,1WWXJ@135613|Chromatiales	135613|Chromatiales	S	PFAM ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
k59_343865_1	1123368.AUIS01000008_gene2255	2.61e-49	161.0	COG0680@1|root,COG0680@2|Bacteria,1N3AS@1224|Proteobacteria,1SZPN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_932139_1	1304865.JAGF01000001_gene385	4.55e-38	148.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4F0SH@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_703900_1	177437.HRM2_31790	7.4e-18	79.7	COG1413@1|root,COG1413@2|Bacteria,1RBEY@1224|Proteobacteria,42QE1@68525|delta/epsilon subdivisions,2WKQU@28221|Deltaproteobacteria,2MJEC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3
k59_243020_2	713587.THITH_16215	1.26e-15	79.7	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	-	-	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2,TAT_signal
k59_83288_1	1229909.NSED_03180	3.04e-114	353.0	COG3889@1|root,arCOG01672@2157|Archaea,41SA5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_834402_1	234267.Acid_5024	2.77e-17	82.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
k59_834402_2	861299.J421_5794	2.38e-20	94.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_532822_1	690850.Desaf_2080	6.06e-35	133.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2M845@213115|Desulfovibrionales	28221|Deltaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
k59_532822_2	1121918.ARWE01000001_gene3202	5.62e-29	110.0	2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,43UWE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
k59_275161_1	717231.Flexsi_1121	9.35e-46	162.0	COG0119@1|root,COG0119@2|Bacteria,2GF1G@200930|Deferribacteres	200930|Deferribacteres	E	LeuA allosteric (dimerisation) domain	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_17901_2	1454004.AW11_01689	5.67e-57	187.0	COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,2VIM5@28216|Betaproteobacteria,1KQPQ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_605183_1	945713.IALB_0212	5.28e-85	263.0	COG2385@1|root,COG2385@2|Bacteria	2|Bacteria	D	sporulation resulting in formation of a cellular spore	lytB	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	DUF4922,Glycos_transf_2,SpoIID
k59_512363_1	743720.Psefu_2147	3.32e-13	70.5	COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,1RTVZ@1236|Gammaproteobacteria,1YWT4@136845|Pseudomonas putida group	1236|Gammaproteobacteria	D	Anion-transporting ATPase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_675851_1	1123511.KB905870_gene106	3.06e-49	174.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,4H25E@909932|Negativicutes	909932|Negativicutes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_902106_1	977880.RALTA_A0024	2.28e-49	162.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1K4S6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_839198_1	1499967.BAYZ01000041_gene2386	1.83e-69	223.0	COG1593@1|root,COG1593@2|Bacteria,2NQTB@2323|unclassified Bacteria	2|Bacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_708647_1	159087.Daro_3548	4.78e-29	112.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2VHU3@28216|Betaproteobacteria,2KUX6@206389|Rhodocyclales	206389|Rhodocyclales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
k59_88057_1	522306.CAP2UW1_1790	7.94e-43	154.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_88057_2	1540221.JQNI01000002_gene2036	2.53e-12	65.5	COG1622@1|root,COG1622@2|Bacteria,1WJJY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	cytochrome c oxidase subunit II	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2-transmemb
k59_217561_1	395494.Galf_2673	8.88e-35	122.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2VRRV@28216|Betaproteobacteria,44VZP@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_217561_2	469381.Dpep_2142	7.33e-15	76.3	COG1057@1|root,COG1057@2|Bacteria,3TA6U@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_512381_1	926569.ANT_29330	2.18e-50	168.0	COG1209@1|root,COG1209@2|Bacteria,2G6MR@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_512381_2	469618.FVAG_00348	6e-30	117.0	COG1091@1|root,COG1898@1|root,COG1091@2|Bacteria,COG1898@2|Bacteria,37946@32066|Fusobacteria	32066|Fusobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind,dTDP_sugar_isom
k59_185074_1	760117.JN27_01510	2.45e-32	128.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,47266@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	gspE1	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_348444_1	1000565.METUNv1_00755	1e-81	254.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,2KUBR@206389|Rhodocyclales	206389|Rhodocyclales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_741082_1	436308.Nmar_1299	8.68e-37	142.0	COG0642@1|root,COG0840@1|root,arCOG02344@2157|Archaea,arCOG02358@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	2.7.13.3	ko:K03406,ko:K07709	ko02020,ko02030,map02020,map02030	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,MCPsignal,dCache_1
k59_1000831_1	94122.Shewana3_2500	2.56e-29	118.0	COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2NX@1236|Gammaproteobacteria,2Q91E@267890|Shewanellaceae	1236|Gammaproteobacteria	P	TonB-dependent receptor plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1000831_2	1394178.AWOO02000024_gene5621	1.19e-35	129.0	COG1024@1|root,COG1024@2|Bacteria,2GJ1A@201174|Actinobacteria,4EI73@85012|Streptosporangiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA15	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_247050_1	1216976.AX27061_5890	1.09e-55	187.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VH5N@28216|Betaproteobacteria,3T345@506|Alcaligenaceae	28216|Betaproteobacteria	Q	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component	mlaE_2	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_54423_1	375286.mma_0581	2.05e-102	312.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,4739Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Gamma-glutamyltranspeptidase	ggt1	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_577693_1	1033810.HLPCO_000996	5.43e-112	340.0	COG2987@1|root,COG2987@2|Bacteria,2NP09@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016153,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_0688	Urocanase,Urocanase_C,Urocanase_N
k59_675883_1	1232410.KI421412_gene401	2.82e-55	187.0	COG2956@1|root,COG2956@2|Bacteria,1Q9XQ@1224|Proteobacteria,43DVZ@68525|delta/epsilon subdivisions,2WJ2G@28221|Deltaproteobacteria,43SC7@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
k59_217587_1	335543.Sfum_1954	4.14e-119	364.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WIPN@28221|Deltaproteobacteria,2MR73@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM NADH-quinone oxidoreductase, chain G	nuoG-2	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_380304_1	706587.Desti_3109	9.45e-106	314.0	COG0455@1|root,COG0455@2|Bacteria,1MW3G@1224|Proteobacteria,42NA9@68525|delta/epsilon subdivisions,2WKEE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	GSCFA family	-	-	-	-	-	-	-	-	-	-	-	-	GSCFA
k59_22579_1	460265.Mnod_5832	8.29e-44	157.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria,1JUTG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_120302_1	1120956.JHZK01000002_gene930	6.69e-166	495.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,1JN1Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Alpha-amylase domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_902146_1	926569.ANT_22020	6.03e-87	265.0	COG1005@1|root,COG1005@2|Bacteria	2|Bacteria	C	quinone binding	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_22583_1	264732.Moth_1900	2.54e-59	194.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,25B35@186801|Clostridia,42FFN@68295|Thermoanaerobacterales	186801|Clostridia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_969602_1	1144319.PMI16_04286	1.93e-40	147.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,472BW@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_152947_1	195253.Syn6312_0212	1.19e-61	207.0	COG1053@1|root,COG1053@2|Bacteria,1G2KV@1117|Cyanobacteria,1H45S@1129|Synechococcus	1117|Cyanobacteria	C	succinate dehydrogenase	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_577715_1	543728.Vapar_2780	9.78e-14	71.2	COG0251@1|root,COG0251@2|Bacteria,1RH8Y@1224|Proteobacteria,2WF2R@28216|Betaproteobacteria,4AI52@80864|Comamonadaceae	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_22592_1	204669.Acid345_4145	9.69e-41	147.0	COG0416@1|root,COG0416@2|Bacteria,3Y3MM@57723|Acidobacteria,2JHTJ@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_741119_1	1279019.ARQK01000054_gene219	4.09e-60	200.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_675905_1	76114.ebA4777	5.33e-96	293.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,2KV9G@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
k59_314263_1	330214.NIDE2539	4.62e-23	95.1	COG0540@1|root,COG0540@2|Bacteria,3J0FJ@40117|Nitrospirae	40117|Nitrospirae	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_314263_2	330214.NIDE2540	2.07e-81	253.0	COG0044@1|root,COG0044@2|Bacteria,3J0D7@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_217608_1	748247.AZKH_2015	2.51e-50	174.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,2VVJQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_217608_2	861299.J421_5665	3.15e-07	55.5	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_936960_1	1207075.PputUW4_03346	8.14e-125	372.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_839269_1	1121875.KB907558_gene547	0.000235	46.2	2EPER@1|root,33H1D@2|Bacteria,4NZ37@976|Bacteroidetes,1I6B9@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_445757_2	1122197.ATWI01000009_gene1588	1.39e-10	64.3	COG4970@1|root,COG4970@2|Bacteria,1QXFS@1224|Proteobacteria,1T3AT@1236|Gammaproteobacteria,46D49@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	general secretion pathway protein H	gspH	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
k59_248026_1	1232437.KL662050_gene5331	3.33e-161	475.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1R9T9@1224|Proteobacteria,42PPQ@68525|delta/epsilon subdivisions,2WKI9@28221|Deltaproteobacteria,2MJ5A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
k59_840407_1	349966.DJ58_1344	1.2e-20	89.4	COG3940@1|root,COG3940@2|Bacteria,1NKF0@1224|Proteobacteria,1RNIH@1236|Gammaproteobacteria,41H8K@629|Yersinia	1236|Gammaproteobacteria	G	Glycosyl hydrolases family 43	abf2	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
k59_840407_2	1122194.AUHU01000010_gene3108	5.78e-28	112.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,464K4@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG2211 Na melibiose symporter and related transporters	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k59_578894_1	1121106.JQKB01000005_gene2131	5.7e-47	162.0	COG0111@1|root,COG0111@2|Bacteria,1P7J3@1224|Proteobacteria,2TV9K@28211|Alphaproteobacteria,2JVX1@204441|Rhodospirillales	204441|Rhodospirillales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_578894_2	1411123.JQNH01000001_gene919	1.39e-49	167.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TRZE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_121416_1	1227457.C451_06570	3.83e-29	116.0	COG3473@1|root,arCOG02004@2157|Archaea,2XUJ3@28890|Euryarchaeota,23TWM@183963|Halobacteria	183963|Halobacteria	Q	Maleate cis-trans isomerase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
k59_121416_2	1122915.AUGY01000118_gene6532	4.6e-32	123.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	ko:K02575,ko:K08223	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.35,2.A.1.8	-	-	MFS_1
k59_55463_1	1123367.C666_05445	1.58e-24	100.0	COG4726@1|root,COG4726@2|Bacteria,1N9CE@1224|Proteobacteria,2VWPP@28216|Betaproteobacteria,2KXMR@206389|Rhodocyclales	206389|Rhodocyclales	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_578895_1	296591.Bpro_2800	2.59e-125	373.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VHRD@28216|Betaproteobacteria,4ABWV@80864|Comamonadaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	oxc	-	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100	-	R01908	RC00620	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_513560_1	977880.RALTA_A2980	5.48e-40	154.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1K1A4@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefC	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_938114_1	987059.RBXJA2T_03978	3.25e-50	167.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,1KKKS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	regulatory protein Crp	nnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_770484_1	583345.Mmol_1916	4.81e-27	115.0	COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,2VJHS@28216|Betaproteobacteria,2KKQ9@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM sulfatase	-	-	2.7.8.43	ko:K03760	ko01503,map01503	M00722	R11555,R11556,R11557	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DUF1705,Sulfatase
k59_938119_1	748247.AZKH_4331	1.83e-88	279.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,2KU8J@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_476353_1	1121405.dsmv_1449	6.63e-64	208.0	COG0674@1|root,COG0674@2|Bacteria,1MWCI@1224|Proteobacteria,42NJY@68525|delta/epsilon subdivisions,2WIW3@28221|Deltaproteobacteria,2MHPN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	vorA	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1307	PFOR_II,POR_N
k59_89270_1	933262.AXAM01000040_gene1219	3.26e-81	250.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MI7P@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_89270_2	177437.HRM2_37580	5.82e-12	60.5	COG1146@1|root,COG1146@2|Bacteria,1NJJD@1224|Proteobacteria,42VKY@68525|delta/epsilon subdivisions,2WRXE@28221|Deltaproteobacteria,2MKYB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7
k59_643290_1	690597.JH730961_gene4727	2.59e-09	62.4	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,1RQ5K@1236|Gammaproteobacteria,1YS9C@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	5.3.3.7	ko:K02020,ko:K22003	ko00660,ko02010,map00660,map02010	M00189	R02244	RC00668	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_840434_1	1380394.JADL01000014_gene153	2.97e-77	256.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JP8A@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_578913_1	398767.Glov_1376	1.39e-26	113.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_643291_1	882086.SacxiDRAFT_4240	8.66e-14	77.0	COG1032@1|root,COG1032@2|Bacteria,2HW72@201174|Actinobacteria,4EB1B@85010|Pseudonocardiales	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_871644_1	717785.HYPMC_1741	6.46e-56	187.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria,3N99C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_381371_1	247633.GP2143_12991	2.94e-73	233.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1S0H1@1236|Gammaproteobacteria,1JBTT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Zn-dependent alcohol dehydrogenases	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_903230_1	13689.BV96_02367	5.57e-152	444.0	COG1884@1|root,COG1884@2|Bacteria,1R6HS@1224|Proteobacteria,2UQDT@28211|Alphaproteobacteria,2K98J@204457|Sphingomonadales	204457|Sphingomonadales	I	Methylmalonyl-CoA mutase	-	-	-	-	-	-	-	-	-	-	-	-	MM_CoA_mutase
k59_381375_1	292415.Tbd_1494	8.01e-31	115.0	COG5642@1|root,COG5642@2|Bacteria,1N1FN@1224|Proteobacteria,2VTKN@28216|Betaproteobacteria,1KT0P@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
k59_381375_2	1234364.AMSF01000025_gene3609	7.97e-17	78.2	COG5654@1|root,COG5654@2|Bacteria,1PZ17@1224|Proteobacteria,1T1AH@1236|Gammaproteobacteria,1X4UE@135614|Xanthomonadales	135614|Xanthomonadales	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
k59_840445_1	1283299.AUKG01000002_gene4291	1.2e-50	181.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4CPJ8@84995|Rubrobacteria	84995|Rubrobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_871656_1	587753.EY04_18220	6.07e-09	58.5	COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,1RPQ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	type VI secretion protein	icmF	-	-	ko:K11891	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	IcmF-related,IcmF_C,ImcF-related_N
k59_871656_2	1123504.JQKD01000008_gene5405	1.94e-38	140.0	COG1360@1|root,COG3455@1|root,COG1360@2|Bacteria,COG3455@2|Bacteria,1MU13@1224|Proteobacteria,2VMB4@28216|Betaproteobacteria,4A9TK@80864|Comamonadaceae	28216|Betaproteobacteria	N	TIGRFAM type IV VI secretion system protein, DotU family	-	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DotU,OmpA
k59_513597_1	556268.OFAG_01447	3.15e-33	124.0	COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2VQPA@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_513597_2	987059.RBXJA2T_15018	7.88e-05	44.7	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2VHAC@28216|Betaproteobacteria	28216|Betaproteobacteria	E	COG0626 Cystathionine beta-lyases cystathionine gamma-synthases	metC	-	2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K01761	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
k59_186179_1	588596.U9U3U5	5.74e-60	203.0	COG1038@1|root,KOG0369@2759|Eukaryota,39RBB@33154|Opisthokonta,3NW8J@4751|Fungi	4751|Fungi	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	PYC1	GO:0003674,GO:0003824,GO:0004736,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006091,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016874,GO:0016885,GO:0019318,GO:0019319,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iMM904.YGL062W,iND750.YGL062W	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
k59_411361_1	1279038.KB907339_gene1210	7.43e-14	72.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,2JQM1@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_411361_2	365046.Rta_25150	1.93e-41	146.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,4AD1I@80864|Comamonadaceae	28216|Betaproteobacteria	C	cytochrome d ubiquinol oxidase, subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_677129_1	288000.BBta_1057	1.1e-12	72.8	COG2730@1|root,COG2730@2|Bacteria,1R544@1224|Proteobacteria,2U1MT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
k59_154135_1	292415.Tbd_1768	8.52e-37	126.0	2E1DK@1|root,32WSU@2|Bacteria,1N3VJ@1224|Proteobacteria,2VV0D@28216|Betaproteobacteria,1KTBR@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_154135_2	1163617.SCD_n02145	1.89e-13	67.8	COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,2VHDT@28216|Betaproteobacteria	28216|Betaproteobacteria	E	phosphoserine phosphatase	thrH	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Hydrolase
k59_610993_1	1244869.H261_01082	5.54e-85	270.0	COG5309@1|root,COG5309@2|Bacteria,1MWJJ@1224|Proteobacteria,2U19Q@28211|Alphaproteobacteria,2JQVV@204441|Rhodospirillales	204441|Rhodospirillales	G	beta (1-6) glucans synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17
k59_742322_1	330214.NIDE1572	8.58e-34	120.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_218737_1	1122604.JONR01000009_gene2421	6.53e-92	273.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,1X4P0@135614|Xanthomonadales	135614|Xanthomonadales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_677130_1	1043493.BBLU01000002_gene1720	4.51e-30	117.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,2GJ0A@201174|Actinobacteria	201174|Actinobacteria	E	Glutamate synthase	preT	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3
k59_677130_2	1255043.TVNIR_3268	1.44e-61	206.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1WX9G@135613|Chromatiales	135613|Chromatiales	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_825952_3	1168059.KB899087_gene1279	4.83e-61	206.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3F11J@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_9662_1	1047013.AQSP01000142_gene143	3.33e-13	69.7	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_727871_1	1415779.JOMH01000001_gene3114	4.4e-75	236.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1SWJJ@1236|Gammaproteobacteria,1X545@135614|Xanthomonadales	135614|Xanthomonadales	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
k59_270566_1	768671.ThimaDRAFT_3191	8.54e-16	83.6	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,1WYW3@135613|Chromatiales	135613|Chromatiales	O	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8,Trans_reg_C
k59_270567_1	452637.Oter_1465	4.05e-65	201.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nrfC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809	-	ko:K04014,ko:K08353,ko:K08358,ko:K16293	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10149,R10150	RC02823,RC03109	ko00000,ko00001,ko02000	5.A.3.10,5.A.3.5	-	iUMNK88_1353.UMNK88_4933	Fer4,Fer4_11,Fer4_3,Fer4_4
k59_434721_1	469618.FVAG_01230	2.87e-25	106.0	COG2721@1|root,COG2721@2|Bacteria,3786R@32066|Fusobacteria	32066|Fusobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7	ko:K16850	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
k59_43444_1	1123354.AUDR01000002_gene1515	8.88e-69	231.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,1KSBS@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Ribonucleotide reductase, barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_red_lgC
k59_337187_1	522306.CAP2UW1_1751	3.79e-100	296.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_500899_1	305700.B447_05650	2.03e-30	113.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,2VRJF@28216|Betaproteobacteria,2KWJJ@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
k59_500899_2	1288494.EBAPG3_18390	1.14e-12	67.8	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,372M0@32003|Nitrosomonadales	28216|Betaproteobacteria	LU	DNA recombination-mediator protein A	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_925257_1	748280.NH8B_2766	6.01e-85	280.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_11078_1	196367.JNFG01000202_gene2631	7.72e-103	314.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VPJT@28216|Betaproteobacteria,1K3NE@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PhaC_N
k59_303871_1	1286631.X805_19780	1.74e-26	102.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,1KM61@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	system-associated acyl-CoA thioesterase	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_303871_2	1434929.X946_1605	1.32e-27	106.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,1K1BT@119060|Burkholderiaceae	28216|Betaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_566090_1	991905.SL003B_0653	2.28e-106	324.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,4BRU7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	FtsH Extracellular	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_141494_2	1396858.Q666_12615	3.07e-61	193.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,464SC@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	ycbL	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_989719_1	1288494.EBAPG3_22420	4.96e-49	170.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,372CV@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_989719_2	335283.Neut_1646	3.58e-184	546.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,37258@32003|Nitrosomonadales	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_369518_1	402626.Rpic_1944	2.89e-12	67.4	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1K1V8@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_369518_2	945713.IALB_2978	5.87e-40	148.0	COG2609@1|root,COG2609@2|Bacteria	2|Bacteria	C	pyruvate dehydrogenase (acetyl-transferring) activity	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_957810_2	395965.Msil_2953	7.02e-74	240.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,3NAGC@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_43470_1	219305.MCAG_01128	2.47e-40	147.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4D9TQ@85008|Micromonosporales	201174|Actinobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_696887_1	1128421.JAGA01000002_gene1308	8.06e-54	176.0	COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_206493_1	1121405.dsmv_1463	6.97e-77	254.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,42P3Z@68525|delta/epsilon subdivisions,2WKRN@28221|Deltaproteobacteria,2MJ14@213118|Desulfobacterales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer2_BFD,GCV_T,GCV_T_C,Pyr_redox_2
k59_43482_1	383372.Rcas_1861	1.58e-38	150.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,2G64H@200795|Chloroflexi,376N2@32061|Chloroflexia	32061|Chloroflexia	HP	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
k59_43482_2	278963.ATWD01000002_gene976	3.44e-52	175.0	COG1064@1|root,COG1064@2|Bacteria,3Y2QS@57723|Acidobacteria	57723|Acidobacteria	S	Zinc-binding dehydrogenase	-	-	-	ko:K12957	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_174170_1	330214.NIDE3153	3.21e-87	273.0	COG3746@1|root,COG3746@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
k59_859312_2	1122225.AULQ01000002_gene634	4.84e-10	56.2	2DXE8@1|root,344N7@2|Bacteria,4P52G@976|Bacteroidetes,1IAPY@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_729365_1	1236959.BAMT01000002_gene2266	0.000421	46.6	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,2KMNB@206350|Nitrosomonadales	206350|Nitrosomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_729365_2	420662.Mpe_A3635	1.29e-11	63.2	2EDY7@1|root,30V4M@2|Bacteria,1RGIS@1224|Proteobacteria,2VQT2@28216|Betaproteobacteria,1KKZ3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_891513_1	1304885.AUEY01000052_gene1554	2.02e-55	193.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42P9Y@68525|delta/epsilon subdivisions,2WM6A@28221|Deltaproteobacteria,2MJCC@213118|Desulfobacterales	28221|Deltaproteobacteria	NTU	General secretory system II protein E domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,T2SSE,T2SSE_N
k59_206507_1	1123269.NX02_17480	4.88e-67	205.0	COG3293@1|root,COG3293@2|Bacteria,1RAWR@1224|Proteobacteria,2VFKZ@28211|Alphaproteobacteria,2K44S@204457|Sphingomonadales	204457|Sphingomonadales	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_566130_1	1283300.ATXB01000001_gene1256	1.7e-199	568.0	COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,1RZ5G@1236|Gammaproteobacteria,1XDSE@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Formylmethanofuran dehydrogenase, subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
k59_566134_1	580332.Slit_1671	1.65e-50	177.0	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,44V1J@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Oxidoreductase FAD-binding domain protein	ascD	-	1.17.1.1	ko:K00523,ko:K18248	ko00520,ko00627,ko01120,map00520,map00627,map01120	M00637	R00823,R00825,R03391,R03392	RC00192,RC00230	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_500957_1	930166.CD58_17470	7.42e-176	513.0	COG1538@1|root,COG1538@2|Bacteria,1MUHM@1224|Proteobacteria,1RNNS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_369565_1	1000565.METUNv1_01684	7.5e-12	65.5	28RH4@1|root,2ZDW4@2|Bacteria,1RAWH@1224|Proteobacteria,2VWZI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	phage protein Ypo2114 SWALL Q8ZEP6 (EMBL AJ414151) (194 aa) fasta scores E() 1.8e-08, 36.93 id in 111 aa	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_925323_1	1085623.GNIT_3410	9.26e-59	189.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,46AYH@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_174190_1	1218076.BAYB01000030_gene4909	6.8e-73	226.0	COG1802@1|root,COG1802@2|Bacteria,1MXNF@1224|Proteobacteria,2VKBY@28216|Betaproteobacteria,1K4DZ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_859335_1	768671.ThimaDRAFT_2665	6.53e-22	95.9	COG5473@1|root,COG5473@2|Bacteria,1R8RR@1224|Proteobacteria,1S0TC@1236|Gammaproteobacteria,1WWZI@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_859335_2	768671.ThimaDRAFT_1300	1.12e-51	172.0	COG1714@1|root,COG1714@2|Bacteria,1RIE9@1224|Proteobacteria,1S566@1236|Gammaproteobacteria,1WY4A@135613|Chromatiales	135613|Chromatiales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_108919_1	246197.MXAN_4928	8.23e-21	91.3	COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,42QX6@68525|delta/epsilon subdivisions,2WN2A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_337262_1	465515.Mlut_08850	1.63e-11	71.2	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,1W8BA@1268|Micrococcaceae	201174|Actinobacteria	E	aminotransferase class I and II	dapC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260,ko:K14267	ko00220,ko00250,ko00270,ko00290,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R04475,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv0858c	Aminotran_1_2
k59_369575_2	261292.Nit79A3_3343	6.87e-56	179.0	COG1225@1|root,COG1225@2|Bacteria,1RH4P@1224|Proteobacteria,2VT1P@28216|Betaproteobacteria,3732D@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_696943_1	1121405.dsmv_1590	7.55e-72	223.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2WNK6@28221|Deltaproteobacteria,2MJM4@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_76554_1	1265505.ATUG01000002_gene1492	2.13e-05	46.2	COG0457@1|root,COG1123@1|root,COG0457@2|Bacteria,COG1123@2|Bacteria,1QU0J@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,TPR_8,Trans_reg_C
k59_76554_2	522306.CAP2UW1_3569	2.53e-14	81.3	2DUXW@1|root,33SXA@2|Bacteria,1NT4U@1224|Proteobacteria	1224|Proteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
k59_400790_2	195250.CM001776_gene3810	1.06e-43	150.0	COG0020@1|root,COG0020@2|Bacteria,1G1NW@1117|Cyanobacteria,1GZH2@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_11168_1	436308.Nmar_1789	1.19e-46	155.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
k59_174213_1	1128421.JAGA01000002_gene900	3.48e-59	194.0	COG0499@1|root,COG0499@2|Bacteria,2NNQE@2323|unclassified Bacteria	2|Bacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_369591_1	323848.Nmul_A0670	3.66e-144	437.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,3729D@32003|Nitrosomonadales	28216|Betaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_400795_1	1177179.A11A3_15965	4.14e-23	98.2	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,1SE17@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulphur transport	-	-	-	-	-	-	-	-	-	-	-	-	Sulf_transp
k59_925353_2	436308.Nmar_1098	7.54e-33	124.0	COG0608@1|root,arCOG00424@2157|Archaea,41SE2@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
k59_76568_1	714943.Mucpa_1029	9.9e-86	260.0	COG0412@1|root,COG0412@2|Bacteria,4NEUX@976|Bacteroidetes,1IPA9@117747|Sphingobacteriia	976|Bacteroidetes	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_957899_2	909663.KI867149_gene3250	9.59e-14	75.9	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,42X97@68525|delta/epsilon subdivisions,2WNMY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KL	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
k59_174220_1	1123020.AUIE01000006_gene4212	6.88e-07	55.1	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1YDII@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
k59_174220_2	266265.Bxe_A1900	1.39e-05	47.8	COG1499@1|root,COG1499@2|Bacteria,1RD49@1224|Proteobacteria,2VRQB@28216|Betaproteobacteria,1K8NR@119060|Burkholderiaceae	28216|Betaproteobacteria	J	ribosomal large subunit export from nucleus	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_369593_1	204773.HEAR3104	8.31e-41	146.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,472I3@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_631067_1	305700.B447_02873	1.58e-96	293.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VJD8@28216|Betaproteobacteria,2KU6C@206389|Rhodocyclales	206389|Rhodocyclales	E	COG0436 Aspartate tyrosine aromatic aminotransferase	-	-	2.6.1.88	ko:K14287	-	-	R08618	RC00006,RC00025	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_827505_1	765911.Thivi_0286	9.06e-125	374.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,1RR5C@1236|Gammaproteobacteria,1WXCT@135613|Chromatiales	135613|Chromatiales	T	in signal transduction	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
k59_76578_1	401053.AciPR4_2097	6.85e-32	119.0	COG5424@1|root,COG5424@2|Bacteria,3Y3MF@57723|Acidobacteria,2JIF5@204432|Acidobacteriia	204432|Acidobacteriia	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
k59_76578_2	497321.C664_00680	1.11e-31	122.0	COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,2VJUF@28216|Betaproteobacteria,2KVU8@206389|Rhodocyclales	206389|Rhodocyclales	S	May be involved in the transport of PQQ or its precursor to the periplasm	pqqB	-	-	ko:K06136	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
k59_303962_1	1158756.AQXQ01000012_gene1500	1.32e-35	125.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1WWN9@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_303962_2	1120999.JONM01000002_gene969	1.64e-53	178.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,2KQ59@206351|Neisseriales	206351|Neisseriales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_529588_1	330214.NIDE1926	1.21e-18	81.6	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	amcY	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cupredoxin_1
k59_529588_2	330214.NIDE1925	1.91e-57	184.0	COG0589@1|root,COG0589@2|Bacteria,3J1E9@40117|Nitrospirae	40117|Nitrospirae	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_759781_1	926569.ANT_06990	5.51e-87	270.0	COG2317@1|root,COG2317@2|Bacteria,2G7UQ@200795|Chloroflexi	200795|Chloroflexi	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
k59_408307_1	379731.PST_2619	1.83e-51	173.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1Z0EF@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	EH	COG0115 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	pabC	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008696,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042558,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_177,iE2348C_1286.E2348C_1188,iECED1_1282.ECED1_1239,iECNA114_1301.ECNA114_1153,iECOK1_1307.ECOK1_1203,iECS88_1305.ECS88_1110,iECSF_1327.ECSF_0995,iECUMN_1333.ECUMN_1273,iJN746.PP_1917,iPC815.YPO1603,iUMN146_1321.UM146_11845,iUTI89_1310.UTI89_C1222,ic_1306.c1366	Aminotran_4
k59_767382_1	945713.IALB_2669	2.9e-39	137.0	28HP3@1|root,2Z7X8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_346163_1	330214.NIDE1472	1.42e-73	233.0	COG0513@1|root,COG0513@2|Bacteria,3J0ZA@40117|Nitrospirae	40117|Nitrospirae	F	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_934537_1	330214.NIDE1132	4e-181	526.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	glgX	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
k59_575286_2	395493.BegalDRAFT_0741	2.9e-47	165.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,460GP@72273|Thiotrichales	72273|Thiotrichales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_346168_1	395493.BegalDRAFT_2006	9.16e-98	297.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,45ZT0@72273|Thiotrichales	72273|Thiotrichales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_738738_2	1121931.AUHG01000010_gene549	2.29e-39	140.0	COG0158@1|root,COG0158@2|Bacteria,4NG06@976|Bacteroidetes,1HX4M@117743|Flavobacteriia	976|Bacteroidetes	G	Belongs to the FBPase class 1 family	fbp	-	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
k59_639870_1	991905.SL003B_4329	4.3e-87	272.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,4BP6M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_150624_1	378806.STAUR_6729	9.08e-76	236.0	COG2085@1|root,COG2085@2|Bacteria,1RCXR@1224|Proteobacteria,43070@68525|delta/epsilon subdivisions,2WVFX@28221|Deltaproteobacteria,2Z1E9@29|Myxococcales	28221|Deltaproteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_706336_1	103690.17129690	2.83e-46	159.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1G3NQ@1117|Cyanobacteria,1HP4J@1161|Nostocales	1117|Cyanobacteria	KT	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
k59_312188_1	565045.NOR51B_2663	2.55e-85	263.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria	1224|Proteobacteria	I	acyl-CoA dehydrogenase	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_836846_2	76114.ebA5465	7.86e-15	75.9	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,2KUKH@206389|Rhodocyclales	206389|Rhodocyclales	T	Sigma E regulatory protein, MucB RseB	rseB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_836847_1	323848.Nmul_A2690	2.82e-77	241.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,372YX@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_346186_1	439235.Dalk_2712	7.23e-21	89.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,2MIEW@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_346186_2	1121405.dsmv_1294	2.33e-54	174.0	COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,2MJM3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_473429_1	331869.BAL199_16928	3.28e-134	390.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_473429_2	1041146.ATZB01000075_gene406	2.84e-58	185.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,4BCFB@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_473433_1	1265313.HRUBRA_02298	1.37e-97	290.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0501 Zn-dependent protease with chaperone function	Z012_09445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_85734_1	436308.Nmar_1592	1.82e-74	224.0	arCOG07348@1|root,arCOG07348@2157|Archaea,41SUQ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_85734_2	1229909.NSED_08620	7.39e-66	207.0	arCOG10593@1|root,arCOG10593@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_276336_1	1274524.BSONL12_06623	2.26e-35	134.0	COG2124@1|root,COG2124@2|Bacteria,1TPWZ@1239|Firmicutes,4HAGS@91061|Bacilli,1ZC1Y@1386|Bacillus	91061|Bacilli	C	Cytochrome P450	yjiB	GO:0003674,GO:0003824,GO:0004497,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0046164,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1902652	-	-	-	-	-	-	-	-	-	-	p450
k59_738772_1	94624.Bpet3758	4.08e-97	298.0	COG2801@1|root,COG2801@2|Bacteria,1MUSB@1224|Proteobacteria,2VP7Z@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,HTH_Tnp_Mu_1,Mu-transpos_C,rve
k59_183076_1	436308.Nmar_1320	3.56e-98	307.0	COG1205@1|root,arCOG00555@2157|Archaea,41SZS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_312204_1	880073.Calab_0992	1.16e-82	254.0	COG2006@1|root,COG2006@2|Bacteria,2NQF7@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_533940_1	1194972.MVAC_02464	2.08e-68	229.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,233RN@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_607538_1	1123392.AQWL01000002_gene1985	8.74e-127	373.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,1KRB4@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_118004_1	1298880.AUEV01000002_gene1555	2.42e-34	126.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
k59_118004_2	1144312.PMI09_05356	2.27e-14	73.9	COG0395@1|root,COG0395@2|Bacteria,1R3R9@1224|Proteobacteria,2TUHE@28211|Alphaproteobacteria,4BBTZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
k59_312210_1	1163409.UUA_15171	4.68e-66	217.0	COG0843@1|root,COG0843@2|Bacteria,1QDZV@1224|Proteobacteria,1RYXY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM cytochrome c oxidase subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_215410_1	1280954.HPO_04300	5.98e-96	285.0	COG0778@1|root,COG0778@2|Bacteria,1MWMJ@1224|Proteobacteria,2TU8B@28211|Alphaproteobacteria,43WQK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_934590_2	1121413.JMKT01000010_gene695	1.48e-51	171.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WMES@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_673547_1	1121405.dsmv_3003	4.66e-70	238.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_639919_2	585.DR95_3539	1.28e-09	61.6	COG0730@1|root,COG0730@2|Bacteria,1MX4T@1224|Proteobacteria,1S132@1236|Gammaproteobacteria,3Z379@583|Proteus	1236|Gammaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_245076_1	290400.Jann_3965	8.22e-13	68.2	COG0778@1|root,COG0778@2|Bacteria,1NIJ8@1224|Proteobacteria,2TUQN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_245076_2	189753.AXAS01000005_gene669	1.25e-45	162.0	COG0477@1|root,COG2814@2|Bacteria,1P3S4@1224|Proteobacteria,2TVAQ@28211|Alphaproteobacteria,3JTFE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_52322_1	388399.SSE37_22312	3.96e-90	273.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	small subunit	hupS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_85754_1	1313172.YM304_29440	4.66e-65	216.0	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,4CN9B@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	-
k59_575341_1	557598.LHK_00579	3.29e-46	160.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,2KPT2@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_575341_2	1304883.KI912532_gene602	8.14e-08	53.5	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,2VKN0@28216|Betaproteobacteria,2KUY8@206389|Rhodocyclales	206389|Rhodocyclales	M	acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_639923_2	266117.Rxyl_1516	6.43e-30	118.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4CP62@84995|Rubrobacteria	84995|Rubrobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_533945_1	1240349.ANGC01000066_gene90	3.4e-93	282.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4FUP9@85025|Nocardiaceae	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_533945_2	279714.FuraDRAFT_0731	5.29e-56	183.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM Transketolase central region	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1021636_3	1479238.JQMZ01000001_gene2169	5.29e-08	53.9	COG0863@1|root,COG0863@2|Bacteria,1MY4G@1224|Proteobacteria,2U1X0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_408364_1	582744.Msip34_2603	2.24e-55	183.0	COG1270@1|root,COG1270@2|Bacteria,1MWCK@1224|Proteobacteria,2VH7X@28216|Betaproteobacteria,2KNPK@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	-	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
k59_408364_2	381666.H16_A1734	1.6e-64	213.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VMXH@28216|Betaproteobacteria,1KCHP@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
k59_473458_1	1223521.BBJX01000013_gene370	0.000666	43.1	COG0589@1|root,COG0589@2|Bacteria,1N02E@1224|Proteobacteria,2VU60@28216|Betaproteobacteria,4AF2I@80864|Comamonadaceae	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_673565_1	396588.Tgr7_2268	9.94e-94	281.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales	135613|Chromatiales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_312231_1	870187.Thini_0278	1.39e-81	256.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,4637B@72273|Thiotrichales	72273|Thiotrichales	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_378222_1	1031711.RSPO_c00743	4.54e-102	319.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1K2P6@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Malic enzyme	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
k59_52341_1	1459636.NTE_02050	2.2e-54	184.0	COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota	651137|Thaumarchaeota	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
k59_998705_2	1485544.JQKP01000002_gene1412	1.96e-36	130.0	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria,44VSN@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
k59_767454_1	1532557.JL37_22815	1.04e-41	156.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,3T20G@506|Alcaligenaceae	28216|Betaproteobacteria	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8
k59_967226_1	497321.C664_10922	3.07e-125	371.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,2KUPY@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_276359_2	395494.Galf_2670	4.6e-57	197.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,44VDQ@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_533955_1	987059.RBXJA2T_07843	9.97e-107	328.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KKC9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_276360_1	1094980.Mpsy_2614	4.44e-64	216.0	COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota,2N91Y@224756|Methanomicrobia	224756|Methanomicrobia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_183127_1	290397.Adeh_2009	9.78e-84	265.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
k59_85788_2	1122244.AUGF01000004_gene1338	3.81e-07	53.1	COG1934@1|root,COG1934@2|Bacteria,1N3J5@1224|Proteobacteria,1SBBI@1236|Gammaproteobacteria,3NJF1@468|Moraxellaceae	1236|Gammaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
k59_20364_1	945713.IALB_1891	1.13e-83	253.0	COG1137@1|root,COG1137@2|Bacteria	2|Bacteria	S	lipopolysaccharide-transporting ATPase activity	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K01990,ko:K06861	ko02010,map02010	M00254,M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1,3.A.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_1021650_2	1265502.KB905935_gene3040	2.85e-100	313.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,4AC0C@80864|Comamonadaceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_408387_2	1382303.JPOM01000001_gene1305	5.93e-06	47.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,2KEZB@204458|Caulobacterales	204458|Caulobacterales	I	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispDF	-	2.7.7.60,4.6.1.12	ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
k59_52363_1	1232683.ADIMK_0110	1.16e-50	171.0	COG2358@1|root,COG2358@2|Bacteria,1Q6GH@1224|Proteobacteria,1RZ7Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_790542_1	373994.Riv7116_1956	6.64e-11	64.3	COG1404@1|root,COG1404@2|Bacteria,1GJ12@1117|Cyanobacteria,1HR09@1161|Nostocales	1117|Cyanobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_607602_1	1459636.NTE_02453	1.16e-52	182.0	COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota	651137|Thaumarchaeota	C	plastoquinone (complex I)	-	-	1.6.5.3	ko:K00342,ko:K12137,ko:K12141	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_739676_2	240016.ABIZ01000001_gene3548	2.04e-38	139.0	COG0577@1|root,COG0577@2|Bacteria,46UT6@74201|Verrucomicrobia,2IVGX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_869132_2	1030157.AFMP01000016_gene2417	1.65e-61	201.0	COG5361@1|root,COG5361@2|Bacteria,1NR2J@1224|Proteobacteria,2UPPV@28211|Alphaproteobacteria,2K216@204457|Sphingomonadales	204457|Sphingomonadales	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_837766_1	1458357.BG58_21650	9.61e-73	226.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,1K3K2@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_245822_1	330214.NIDE0799	8.08e-143	412.0	COG0304@1|root,COG0304@2|Bacteria,3J0DH@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_900801_2	945713.IALB_2927	2.63e-27	117.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CBM_6,DUF1565,PDZ_2,Trypsin_2
k59_379011_1	977880.RALTA_A0321	4.84e-48	163.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2VI10@28216|Betaproteobacteria,1K2ZD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_379011_2	1123354.AUDR01000016_gene1343	5.94e-47	152.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,1KRT0@119069|Hydrogenophilales	119069|Hydrogenophilales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_480642_1	580332.Slit_2634	1.56e-85	275.0	COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,2WHEY@28216|Betaproteobacteria,44V0X@713636|Nitrosomonadales	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_8
k59_584237_2	1322246.BN4_11949	1.16e-08	62.4	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_4,PAS_9,sCache_3_2
k59_584238_1	545276.KB898726_gene1031	1.96e-07	54.7	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_747575_1	330214.NIDE3572	1.94e-49	173.0	28MGX@1|root,2ZATZ@2|Bacteria,3J0YU@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_518826_1	1121033.AUCF01000005_gene5214	1.49e-46	162.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JPIG@204441|Rhodospirillales	204441|Rhodospirillales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_518826_2	1120970.AUBZ01000018_gene3341	1.24e-77	242.0	COG1638@1|root,COG1638@2|Bacteria,1NJX4@1224|Proteobacteria,1S1Q1@1236|Gammaproteobacteria,4664F@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_159065_1	1288494.EBAPG3_7950	6.55e-95	299.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3725J@32003|Nitrosomonadales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_682375_1	876044.IMCC3088_858	1.74e-33	117.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_682375_2	382464.ABSI01000005_gene1406	2.8e-08	57.8	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein,VWA_2,YadA_anchor
k59_845776_1	330214.NIDE4097	1.45e-95	295.0	COG2804@1|root,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae	40117|Nitrospirae	NU	Type II/IV secretion system protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_191161_1	335543.Sfum_1513	2e-34	127.0	COG0664@1|root,COG2897@1|root,COG0664@2|Bacteria,COG2897@2|Bacteria,1PDIN@1224|Proteobacteria,437BC@68525|delta/epsilon subdivisions,2X2G8@28221|Deltaproteobacteria,2MRZR@213462|Syntrophobacterales	28221|Deltaproteobacteria	PT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_191161_2	335543.Sfum_1514	2.23e-49	161.0	COG2259@1|root,COG2259@2|Bacteria,1RIFW@1224|Proteobacteria,42SRS@68525|delta/epsilon subdivisions,2WPBA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM DoxX family protein	-	-	-	-	-	-	-	-	-	-	-	-	MauE
k59_60451_1	926569.ANT_28810	8.22e-94	283.0	COG3425@1|root,COG3425@2|Bacteria,2G606@200795|Chloroflexi	200795|Chloroflexi	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III domain protein	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C
k59_538233_1	314278.NB231_16708	6.92e-76	246.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales	135613|Chromatiales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_28813_1	1125863.JAFN01000001_gene3329	5.11e-47	160.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,43CRY@68525|delta/epsilon subdivisions,2X7ZI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF
k59_28813_2	1125863.JAFN01000001_gene3330	6.23e-09	56.6	2AKQ6@1|root,31BGX@2|Bacteria,1RCS3@1224|Proteobacteria,43CF4@68525|delta/epsilon subdivisions,2WP3G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426,zinc_ribbon_4
k59_793910_1	234267.Acid_3094	4.02e-27	114.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y59I@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_616002_1	1380391.JIAS01000015_gene225	3.01e-43	157.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,2JPCV@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_386157_1	1167006.UWK_02226	1.77e-64	210.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,42M9Y@68525|delta/epsilon subdivisions,2WM8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM sodium hydrogen exchanger	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_518854_1	292415.Tbd_1465	4.35e-118	347.0	COG0462@1|root,COG0462@2|Bacteria,1QHJ7@1224|Proteobacteria,2VJW9@28216|Betaproteobacteria,1KSMN@119069|Hydrogenophilales	119069|Hydrogenophilales	EF	Phosphoribosyl synthetase-associated domain	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_518854_2	292415.Tbd_1388	5.08e-22	91.7	COG0517@1|root,COG0517@2|Bacteria,1QTXQ@1224|Proteobacteria,2VWDB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_415802_1	261292.Nit79A3_3381	9.78e-28	112.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales	28216|Betaproteobacteria	CEH	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_415802_2	395961.Cyan7425_3898	2.22e-32	123.0	COG0161@1|root,COG0161@2|Bacteria	2|Bacteria	H	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	bioA2	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_584279_1	999141.GME_04067	1.77e-99	298.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1XHH6@135619|Oceanospirillales	135619|Oceanospirillales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF-1	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_480675_1	1545915.JROG01000003_gene1450	4.62e-30	118.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,2K016@204457|Sphingomonadales	204457|Sphingomonadales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_451748_1	153948.NAL212_2506	9.52e-130	397.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_451748_2	987059.RBXJA2T_11738	8.6e-08	53.9	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,1KIUU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_943356_1	113395.AXAI01000004_gene4520	8.33e-49	166.0	COG1893@1|root,COG1893@2|Bacteria,1QMH8@1224|Proteobacteria,2TSGW@28211|Alphaproteobacteria,3JWCH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_682425_1	882.DVU_2114	8.28e-32	125.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WM8T@28221|Deltaproteobacteria,2M9IS@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_518875_1	1123367.C666_14675	3.99e-189	532.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,2KVME@206389|Rhodocyclales	206389|Rhodocyclales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_775067_2	290397.Adeh_1683	7.67e-17	82.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,42SVD@68525|delta/epsilon subdivisions,2WPFX@28221|Deltaproteobacteria,2Z010@29|Myxococcales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_354758_1	1123277.KB893195_gene5720	1.77e-35	142.0	COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47U6P@768503|Cytophagia	976|Bacteroidetes	T	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SnoaL_3
k59_747641_1	1538295.JY96_13385	3.9e-103	310.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,1KJD1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_159120_1	436308.Nmar_1616	3.51e-101	296.0	COG0108@1|root,arCOG01320@2157|Archaea,41SFW@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	-	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase
k59_480704_2	521011.Mpal_0881	1.36e-21	96.3	COG1506@1|root,arCOG01646@2157|Archaea,2XUCV@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_682439_1	880072.Desac_2709	1.16e-87	276.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2MQVI@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_480706_1	1045009.AFXQ01000010_gene877	9.27e-08	57.8	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,1W8N3@1268|Micrococcaceae	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_715161_1	1485545.JQLW01000006_gene228	1.91e-05	46.2	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria	1224|Proteobacteria	T	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain	regA	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
k59_715161_2	1132855.KB913035_gene2305	2.86e-19	89.7	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,2VNY1@28216|Betaproteobacteria,2KKSE@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_94568_1	314230.DSM3645_15260	9.49e-05	46.2	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_94568_2	1096546.WYO_1994	2.05e-43	144.0	COG3293@1|root,COG3293@2|Bacteria,1REVC@1224|Proteobacteria,2U6ZB@28211|Alphaproteobacteria,1JW8N@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
k59_682446_1	1236959.BAMT01000006_gene240	6.43e-82	258.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VNYV@28216|Betaproteobacteria,2KMCT@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_682450_1	330214.NIDE3313	3.9e-129	405.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
k59_480715_1	443144.GM21_2679	4.79e-43	162.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions	1224|Proteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Big_5,Neisseria_PilC,PA14
k59_415850_1	1442599.JAAN01000035_gene577	3.18e-47	169.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1X38B@135614|Xanthomonadales	135614|Xanthomonadales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_191237_1	62928.azo2585	2.52e-130	383.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KUR5@206389|Rhodocyclales	206389|Rhodocyclales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
k59_648365_1	1000565.METUNv1_03884	1.74e-61	197.0	2C1VZ@1|root,32R98@2|Bacteria,1RJ8X@1224|Proteobacteria,2VRVA@28216|Betaproteobacteria,2KWXN@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_845863_1	1089553.Tph_c15580	2.43e-24	104.0	COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,248JT@186801|Clostridia,42FM7@68295|Thermoanaerobacterales	186801|Clostridia	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_28892_1	983548.Krodi_2753	3.72e-38	137.0	COG1902@1|root,COG1902@2|Bacteria,4NF98@976|Bacteroidetes,1HYAD@117743|Flavobacteriia,37FIC@326319|Dokdonia	976|Bacteroidetes	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN
k59_943396_1	1449065.JMLL01000010_gene1693	9.07e-79	253.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TS4B@28211|Alphaproteobacteria,43GRQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	cobalamin synthesis protein	p47K	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_354799_1	401526.TcarDRAFT_1693	1e-78	252.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,4H266@909932|Negativicutes	909932|Negativicutes	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_280855_1	365046.Rta_18440	5.27e-201	567.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2VJZV@28216|Betaproteobacteria,4ABSY@80864|Comamonadaceae	28216|Betaproteobacteria	F	PFAM amidohydrolase	-	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_943412_1	1131553.JIBI01000015_gene636	8.63e-135	407.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,372EP@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_538288_1	314278.NB231_13571	1.07e-72	224.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,1WWRQ@135613|Chromatiales	135613|Chromatiales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_94607_1	436308.Nmar_0303	8.28e-38	137.0	COG0598@1|root,arCOG02265@2157|Archaea,41SZC@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Mg2 transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_280860_1	266779.Meso_4454	1.36e-46	165.0	COG4948@1|root,COG4948@2|Bacteria,1R85F@1224|Proteobacteria,2U3MC@28211|Alphaproteobacteria,43JU9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_280860_2	991905.SL003B_1108	1.03e-28	113.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
k59_160104_1	572477.Alvin_0031	2.06e-33	132.0	COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_683464_1	266264.Rmet_2924	2.83e-38	140.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI85@28216|Betaproteobacteria,1K241@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	dld	-	1.1.2.4,1.1.5.12	ko:K00102,ko:K03777	ko00620,ko01120,map00620,map01120	-	R00197,R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_683464_2	1000565.METUNv1_01064	1.31e-37	129.0	COG1917@1|root,COG1917@2|Bacteria,1NJEK@1224|Proteobacteria,2VXYU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
k59_387104_1	1121373.KB903632_gene507	9.18e-18	87.8	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Ig_3,PQQ_2
k59_224576_1	298653.Franean1_3903	4.04e-45	162.0	COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria,4EWBZ@85013|Frankiales	201174|Actinobacteria	L	PFAM transposase IS4 family protein	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1_6,DUF772
k59_355785_1	257310.BB0750	1.59e-77	239.0	COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2VJSH@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Enoyl-CoA hydratase	echA8_4	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_944371_1	1218074.BAXZ01000015_gene3202	3.61e-37	144.0	COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,1K1RH@119060|Burkholderiaceae	28216|Betaproteobacteria	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
k59_481598_1	626418.bglu_1g05110	2.57e-92	284.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1K14Y@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_355789_1	448385.sce4409	1.42e-10	62.8	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,42MJ8@68525|delta/epsilon subdivisions,2WIVP@28221|Deltaproteobacteria,2YUDK@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
k59_748701_1	316067.Geob_3682	1.56e-89	283.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,43TNF@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_61456_1	330214.NIDE0997	1.04e-97	300.0	COG0028@1|root,COG0028@2|Bacteria,3J0D6@40117|Nitrospirae	40117|Nitrospirae	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_617047_1	639283.Snov_0217	6.19e-54	182.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3F1EG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_192226_1	266809.PM03_05785	0.000126	49.7	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2TX00@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_3
k59_452740_1	414684.RC1_1771	7.09e-14	69.3	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,2UC8X@28211|Alphaproteobacteria,2JU1V@204441|Rhodospirillales	204441|Rhodospirillales	OU	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
k59_452740_2	1380391.JIAS01000020_gene1643	8.7e-18	83.2	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,2JPF8@204441|Rhodospirillales	204441|Rhodospirillales	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
k59_846921_1	1123277.KB893200_gene6374	6.7e-51	165.0	COG3415@1|root,COG3415@2|Bacteria,4NSMH@976|Bacteroidetes,47REK@768503|Cytophagia	976|Bacteroidetes	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_846921_2	761193.Runsl_5956	1.67e-25	99.8	COG3335@1|root,COG3335@2|Bacteria,4NM4S@976|Bacteroidetes,47PK6@768503|Cytophagia	976|Bacteroidetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_160141_1	945713.IALB_2283	2.35e-99	316.0	COG0653@1|root,COG0653@2|Bacteria	2|Bacteria	U	protein targeting	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_387140_1	1382304.JNIL01000001_gene1389	5.24e-52	176.0	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli	91061|Bacilli	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_617059_1	710696.Intca_1139	3.01e-24	107.0	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,4FFND@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_160149_1	857087.Metme_0312	2.93e-47	163.0	293CN@1|root,2ZQV6@2|Bacteria,1RF4G@1224|Proteobacteria,1T0P6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_61488_1	945713.IALB_2690	3e-48	171.0	COG0166@1|root,COG0166@2|Bacteria	2|Bacteria	G	Belongs to the GPI family	tal	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
k59_264066_1	765912.Thimo_0109	1.31e-20	83.6	2C7TU@1|root,32RJT@2|Bacteria,1N2CD@1224|Proteobacteria,1S96C@1236|Gammaproteobacteria,1WYZ5@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_264066_2	768671.ThimaDRAFT_3392	4.46e-30	113.0	28QMK@1|root,2ZD39@2|Bacteria,1RAWM@1224|Proteobacteria,1S2FU@1236|Gammaproteobacteria,1WY0Y@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_557955_1	42256.RradSPS_1692	3.02e-92	281.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4CPIW@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_361718_1	859657.RPSI07_0696	2.12e-80	255.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,1K36E@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_361718_2	88036.EFJ30770	1.53e-10	58.5	COG0228@1|root,KOG3419@2759|Eukaryota,37UTU@33090|Viridiplantae,3GIRP@35493|Streptophyta	35493|Streptophyta	J	Ribosomal protein S16	-	GO:0000313,GO:0000314,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009536,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0098798,GO:0140053,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_231033_1	1288494.EBAPG3_27460	1.68e-115	350.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,372RK@32003|Nitrosomonadales	28216|Betaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_231033_2	1195246.AGRI_14930	3.96e-09	58.5	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,464AZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767	NAD_kinase
k59_166064_1	1380394.JADL01000002_gene1394	3.81e-105	318.0	COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria,2JT4J@204441|Rhodospirillales	204441|Rhodospirillales	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_166064_2	1297569.MESS2_1190049	3.36e-78	243.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,43H9K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_100765_1	2340.JV46_27250	3.85e-74	248.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1J4N3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164	PBP1_TM,Transgly,Transpeptidase,UB2H
k59_590520_2	1121035.AUCH01000009_gene854	9.53e-06	48.1	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales	206389|Rhodocyclales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
k59_361732_2	864702.OsccyDRAFT_3043	1.46e-17	85.1	COG0719@1|root,COG0719@2|Bacteria,1G0K0@1117|Cyanobacteria,1H82J@1150|Oscillatoriales	1117|Cyanobacteria	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component	sufD	-	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_427097_1	292415.Tbd_2338	5.86e-75	238.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,1KRNP@119069|Hydrogenophilales	119069|Hydrogenophilales	M	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N
k59_68274_1	933262.AXAM01000046_gene139	2.64e-11	65.5	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2MJ79@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_329211_1	240015.ACP_1314	6.62e-40	139.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096,Recombinase,Resolvase,Zn_ribbon_recom
k59_557990_1	944547.ABLL_2736	5.48e-34	128.0	COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,42XFS@68525|delta/epsilon subdivisions,2YSK1@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_557990_2	202952.BBLI01000016_gene1442	3.65e-16	75.5	COG0346@1|root,COG0346@2|Bacteria,1RDVE@1224|Proteobacteria,1S3QZ@1236|Gammaproteobacteria,3NR5S@468|Moraxellaceae	1236|Gammaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_35561_1	96561.Dole_2837	2.66e-25	107.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,2MIFD@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_721135_1	436308.Nmar_1624	2.34e-100	291.0	COG2238@1|root,arCOG01344@2157|Archaea,41SK1@651137|Thaumarchaeota	651137|Thaumarchaeota	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
k59_296515_1	290397.Adeh_1279	1.69e-46	169.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2YUHH@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_35565_1	1163617.SCD_n01710	1.47e-54	175.0	2DX2X@1|root,32V2M@2|Bacteria,1MZZC@1224|Proteobacteria,2VU2H@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_133526_1	76114.ebA7003	1.23e-155	453.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria,2KUPD@206389|Rhodocyclales	206389|Rhodocyclales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_851517_1	491952.Mar181_0360	2.44e-50	177.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1XH69@135619|Oceanospirillales	135619|Oceanospirillales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_166114_1	85643.Tmz1t_3047	5.55e-91	271.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,2KW7U@206389|Rhodocyclales	206389|Rhodocyclales	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
k59_1013259_1	1469245.JFBG01000044_gene1871	1.9e-118	353.0	COG1653@1|root,COG1653@2|Bacteria,1MV8A@1224|Proteobacteria,1RQ8I@1236|Gammaproteobacteria,1X018@135613|Chromatiales	135613|Chromatiales	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17321	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	SBP_bac_1
k59_394312_1	1223521.BBJX01000007_gene1441	1.27e-82	250.0	COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria,2VI6U@28216|Betaproteobacteria,4ABS9@80864|Comamonadaceae	28216|Betaproteobacteria	C	4Fe-4S single cluster domain	hoxU	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
k59_819257_1	153948.NAL212_1477	6.23e-84	271.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_296534_1	204536.SULAZ_0946	8.5e-10	62.0	COG0490@1|root,COG0490@2|Bacteria,2G45Z@200783|Aquificae	200783|Aquificae	P	TrkA-C domain protein	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
k59_590566_1	596154.Alide2_2167	1.43e-45	161.0	COG0697@1|root,COG4531@1|root,COG0697@2|Bacteria,COG4531@2|Bacteria,1N3FA@1224|Proteobacteria,2VHAD@28216|Betaproteobacteria,4ABD4@80864|Comamonadaceae	28216|Betaproteobacteria	EG	Drug metabolite transporter	cnrT	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_427143_1	614083.AWQR01000014_gene2404	3.96e-05	51.2	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2VIUF@28216|Betaproteobacteria,4AHZS@80864|Comamonadaceae	28216|Betaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	ddc	-	4.1.1.86	ko:K13745	ko00260,ko01120,map00260,map01120	-	R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
k59_884012_1	56780.SYN_00992	1.08e-65	202.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2WP71@28221|Deltaproteobacteria,2MQGG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_884012_2	234267.Acid_5112	1.9e-67	216.0	COG0092@1|root,COG0092@2|Bacteria,3Y3ZN@57723|Acidobacteria	57723|Acidobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_981985_1	314285.KT71_17271	3.74e-49	176.0	COG1404@1|root,COG1404@2|Bacteria,1PE2Y@1224|Proteobacteria,1SQ8B@1236|Gammaproteobacteria,1JBCF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_688671_2	1122917.KB899659_gene5696	4.48e-06	50.1	2DJJX@1|root,306EW@2|Bacteria,1TZP0@1239|Firmicutes,4I8YB@91061|Bacilli,270Q8@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_558037_1	1265502.KB905944_gene718	1.76e-96	311.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,4A9UC@80864|Comamonadaceae	28216|Betaproteobacteria	EQ	5-oxoprolinase	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_753246_1	330214.NIDE3279	1.29e-128	372.0	COG3381@1|root,COG3381@2|Bacteria	2|Bacteria	S	protein complex oligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
k59_231105_1	1254432.SCE1572_31580	5.57e-45	159.0	COG2706@1|root,COG2706@2|Bacteria,1MWTE@1224|Proteobacteria	1224|Proteobacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
k59_297486_1	261292.Nit79A3_1750	1.07e-105	320.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,371M1@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_689724_1	1485545.JQLW01000005_gene1189	9.75e-15	77.8	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria	1224|Proteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA1	-	4.1.1.17,4.1.1.20	ko:K01581,ko:K01586	ko00300,ko00330,ko00480,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map00330,map00480,map01100,map01110,map01120,map01130,map01230	M00016,M00134,M00525,M00526,M00527	R00451,R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_265164_1	1235457.C404_18540	5.6e-42	154.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1K2P6@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Malic enzyme	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
k59_265164_2	1224318.DT73_20525	3e-21	93.6	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0050896,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_689726_1	870187.Thini_0592	6.35e-27	102.0	2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_689726_2	335283.Neut_1531	5.37e-18	83.2	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria,3725F@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_36629_2	945713.IALB_0334	1.11e-30	117.0	COG3481@1|root,COG3481@2|Bacteria	2|Bacteria	D	metal-dependent phosphohydrolase, HD sub domain	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
k59_526065_1	694427.Palpr_1017	2.67e-20	89.4	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2G0EK@200643|Bacteroidia	976|Bacteroidetes	V	AcrB/AcrD/AcrF family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_526065_2	694427.Palpr_1017	3.61e-48	171.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2G0EK@200643|Bacteroidia	976|Bacteroidetes	V	AcrB/AcrD/AcrF family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_689727_1	1121405.dsmv_0316	6.29e-93	296.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42M33@68525|delta/epsilon subdivisions,2WJGS@28221|Deltaproteobacteria,2MIFE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_559128_1	471874.PROSTU_01904	5.39e-08	57.0	COG3566@1|root,COG3566@2|Bacteria,1QWCX@1224|Proteobacteria,1RZS8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2213
k59_428154_2	251229.Chro_1267	8.56e-13	67.4	COG0500@1|root,COG0500@2|Bacteria,1GR1R@1117|Cyanobacteria	2|Bacteria	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_460451_2	580332.Slit_2856	5.52e-77	242.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,44VMS@713636|Nitrosomonadales	28216|Betaproteobacteria	I	PFAM Carbamoyl-phosphate synthase L chain ATP-binding	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1013703_1	1038859.AXAU01000002_gene643	1.07e-21	92.8	COG2358@1|root,COG2358@2|Bacteria,1NRH6@1224|Proteobacteria,2TT34@28211|Alphaproteobacteria,3JTPF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_1013703_2	1453503.AU05_09735	2.75e-60	197.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,1RQ8V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_199832_1	1173020.Cha6605_1310	1.37e-71	231.0	COG5659@1|root,COG5659@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_852563_1	765914.ThisiDRAFT_1083	3.43e-73	224.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales	135613|Chromatiales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_330339_1	649638.Trad_1884	1.9e-34	139.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1WI0Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_983086_1	1437448.AZRT01000031_gene2536	2.99e-134	392.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	MA20_10900	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_820371_1	648757.Rvan_2318	4.92e-60	197.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,3N632@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Permease MlaE	MA20_08115	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS,STAS_2
k59_689767_2	930169.B5T_04202	1.66e-16	82.4	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria	1224|Proteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_591657_1	1123393.KB891317_gene2264	8.49e-105	313.0	COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2VRJN@28216|Betaproteobacteria,1KSUB@119069|Hydrogenophilales	119069|Hydrogenophilales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
k59_591657_2	396588.Tgr7_2285	2.4e-21	93.2	COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,1RXX2@1236|Gammaproteobacteria,1WX24@135613|Chromatiales	135613|Chromatiales	S	VWA-like domain (DUF2201)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201,DUF2201_N
k59_559167_1	472759.Nhal_1189	5.57e-15	74.3	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_559167_2	472759.Nhal_1188	1.72e-31	116.0	COG1814@1|root,COG1814@2|Bacteria,1RBQN@1224|Proteobacteria,1S2ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_199854_1	639283.Snov_1895	1.51e-78	241.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,3EYIK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_265214_1	1127131.WEISSC39_09635	1.08e-08	56.2	COG3716@1|root,COG3716@2|Bacteria,1TQA3@1239|Firmicutes,4HA3K@91061|Bacilli,4AWH1@81850|Leuconostocaceae	91061|Bacilli	G	Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IID	manN	-	-	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1	-	-	EIID-AGA
k59_862365_1	1095769.CAHF01000013_gene3259	2.27e-51	182.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,4726K@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_144785_1	436308.Nmar_0176	1.28e-56	181.0	arCOG10518@1|root,arCOG10518@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_209648_1	1454004.AW11_03698	4.01e-79	240.0	COG0625@1|root,COG0625@2|Bacteria,1RC4Y@1224|Proteobacteria,2VW3S@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase	gstF	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	AHSA1,GST_C,GST_N,GST_N_3
k59_601757_1	640081.Dsui_0513	2.52e-27	114.0	COG2199@1|root,COG2199@2|Bacteria,1QTT5@1224|Proteobacteria,2VKM3@28216|Betaproteobacteria,2KY09@206389|Rhodocyclales	206389|Rhodocyclales	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
k59_700299_1	264198.Reut_A2980	3.72e-19	88.2	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,1K0M1@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_700299_2	614083.AWQR01000021_gene219	1.37e-18	85.9	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,4AAXV@80864|Comamonadaceae	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_340444_1	1496688.ER33_11240	1.73e-11	65.9	COG3000@1|root,COG3000@2|Bacteria,1G441@1117|Cyanobacteria,22T78@167375|Cyanobium	1117|Cyanobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_504202_1	159087.Daro_2611	6.96e-39	134.0	2AENS@1|root,314IU@2|Bacteria,1RINM@1224|Proteobacteria,2VTCG@28216|Betaproteobacteria,2KWJD@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_961211_1	1265505.ATUG01000003_gene511	8.22e-37	125.0	COG1563@1|root,COG1563@2|Bacteria,1N5EN@1224|Proteobacteria,42UDW@68525|delta/epsilon subdivisions,2WQK2@28221|Deltaproteobacteria,2MKZV@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Domain of unknown function (DUF4040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040
k59_961211_2	177437.HRM2_35390	6.82e-29	106.0	COG1320@1|root,COG1320@2|Bacteria,1QFGT@1224|Proteobacteria,42W2H@68525|delta/epsilon subdivisions,2WRRI@28221|Deltaproteobacteria,2MKFZ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit	mnhG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_306916_1	1266925.JHVX01000008_gene269	4.43e-87	272.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,372QA@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_830794_1	1132855.KB913035_gene1010	5.98e-48	162.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,2KM7I@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_437854_1	113395.AXAI01000042_gene6061	1.2e-71	218.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JVIU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_306920_1	436308.Nmar_1777	4.65e-98	290.0	COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota	651137|Thaumarchaeota	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_306920_2	436308.Nmar_1776	8.26e-19	84.0	COG1234@1|root,arCOG00501@2157|Archaea,41SF7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
k59_961220_1	243090.RB1656	1.7e-09	64.3	COG2199@1|root,COG3290@1|root,COG3437@1|root,COG3290@2|Bacteria,COG3437@2|Bacteria,COG3706@2|Bacteria,2IYJM@203682|Planctomycetes	203682|Planctomycetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,PAS_4
k59_372628_1	765910.MARPU_03690	7.2e-82	271.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_437860_1	1123487.KB892868_gene1182	1.56e-13	68.6	COG3909@1|root,COG3909@2|Bacteria,1PT42@1224|Proteobacteria,2WADQ@28216|Betaproteobacteria,2KWK2@206389|Rhodocyclales	206389|Rhodocyclales	C	(sprot CYCP_CHRVI). CYTOCHROME C IS THE MOST WIDELY OCCURRING BACTERIAL C-TYPE CYTOCHROME. CYTOCHROMES C ARE HIGH-SPIN PROTEINS AND THE HEME HAS NO SIXTH LIGAND. THEIR EXACT FUNCTION IS NOT KNOWN	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
k59_437860_2	305700.B447_11597	7.14e-05	46.6	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2VQQ0@28216|Betaproteobacteria,2KW85@206389|Rhodocyclales	206389|Rhodocyclales	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_700324_1	1266925.JHVX01000012_gene1712	7.56e-137	401.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,3727P@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_569457_1	1042377.AFPJ01000051_gene95	2.42e-75	239.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,4642Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1271 Cytochrome bd-type quinol oxidase, subunit 1	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_634173_1	322710.Avin_17500	3.04e-11	63.2	COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria	1224|Proteobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	phnA	-	3.11.1.2	ko:K19670	ko00440,map00440	-	R00318	RC01309	ko00000,ko00001,ko01000	-	-	-	Phosphodiest
k59_634173_2	596154.Alide2_4558	1.9e-105	315.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2VKTZ@28216|Betaproteobacteria,4AB2I@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM 2-aminoethylphosphonate ABC transport system, 1-aminoethylphosphonate-binding protein component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_830811_1	1158182.KB905032_gene1652	6.8e-07	50.4	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1WVWN@135613|Chromatiales	135613|Chromatiales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N
k59_830811_2	857087.Metme_4014	4.25e-67	216.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1XEPY@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_468597_1	1288494.EBAPG3_22420	2.09e-201	570.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,372CV@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_601791_1	1366050.N234_27765	2.86e-73	242.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2VJZW@28216|Betaproteobacteria,1K3Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
k59_209680_1	360094.PXO_00079	4.6e-25	101.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
k59_762402_1	1047013.AQSP01000125_gene2642	1.75e-36	142.0	COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria	2|Bacteria	J	elongation factor G	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_928653_1	525897.Dbac_0595	7.48e-63	207.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,42MBW@68525|delta/epsilon subdivisions,2WK2Z@28221|Deltaproteobacteria,2M972@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	TIGRFAM ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
k59_961233_2	399795.CtesDRAFT_PD1867	5.49e-08	62.0	COG1196@1|root,COG2520@1|root,COG1196@2|Bacteria,COG2520@2|Bacteria,1R01N@1224|Proteobacteria,2VYA0@28216|Betaproteobacteria,4AFUT@80864|Comamonadaceae	28216|Betaproteobacteria	D	TIGRFAM methyltransferase FkbM	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
k59_602982_1	1125973.JNLC01000018_gene2320	1.19e-85	268.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_668809_1	1288494.EBAPG3_28930	4.54e-57	191.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,2VNEP@28216|Betaproteobacteria	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_962482_1	180281.CPCC7001_2411	2.77e-05	50.4	COG2801@1|root,COG3666@1|root,COG2801@2|Bacteria,COG3666@2|Bacteria,1GMTA@1117|Cyanobacteria,22TVU@167375|Cyanobium	1117|Cyanobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_635447_1	1095769.CAHF01000027_gene2743	2.81e-69	225.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VIE4@28216|Betaproteobacteria,474WY@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_210913_1	1380386.JIAW01000006_gene1303	3.6e-19	91.7	COG1020@1|root,COG1020@2|Bacteria,2GPHZ@201174|Actinobacteria,23298@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the long-chain O-acyltransferase family	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
k59_962493_1	279714.FuraDRAFT_3349	4.76e-13	64.3	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KRVU@206351|Neisseriales	206351|Neisseriales	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
k59_962493_2	1454004.AW11_00401	1.24e-30	119.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1KQBE@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_763402_1	96561.Dole_1366	5.02e-33	124.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WP2A@28221|Deltaproteobacteria,2MJYX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_373824_1	1116472.MGMO_105c00550	2.5e-43	161.0	COG2132@1|root,COG2132@2|Bacteria,1QZ1I@1224|Proteobacteria,1S18S@1236|Gammaproteobacteria,1XEXE@135618|Methylococcales	1236|Gammaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22350	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2
k59_210923_1	552525.B5LPN4_9CAUD	4.88e-14	72.0	4QAR6@10239|Viruses,4QUTK@35237|dsDNA viruses  no RNA stage,4QPS2@28883|Caudovirales,4QKTM@10699|Siphoviridae	10699|Siphoviridae	S	dUTPase	-	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429	-	-	-	-	-	-	-	-	-	-	-
k59_274130_1	640081.Dsui_1978	1.03e-61	203.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,2KUM7@206389|Rhodocyclales	206389|Rhodocyclales	M	(Lipo)protein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_241174_1	693661.Arcve_1855	1.92e-05	48.1	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,245P1@183980|Archaeoglobi	183980|Archaeoglobi	C	hydrogenase large subunit	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_603023_1	557598.LHK_02526	7.75e-44	156.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VK3W@28216|Betaproteobacteria,2KQH0@206351|Neisseriales	206351|Neisseriales	L	DNA polymerase III, epsilon subunit	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T
k59_603023_2	1123393.KB891332_gene2723	4.75e-60	194.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,1KRM2@119069|Hydrogenophilales	119069|Hydrogenophilales	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_47942_1	7091.BGIBMGA005089-TA	3.91e-05	45.1	COG0740@1|root,KOG0840@2759|Eukaryota,38PE0@33154|Opisthokonta,3BEPT@33208|Metazoa,3CVZ0@33213|Bilateria,41UZT@6656|Arthropoda,3SFTD@50557|Insecta,449MH@7088|Lepidoptera	33208|Metazoa	O	Clp protease	CLPP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006986,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009368,GO:0009987,GO:0010033,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022607,GO:0030163,GO:0031974,GO:0032991,GO:0033554,GO:0034514,GO:0034620,GO:0035966,GO:0035967,GO:0042221,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051259,GO:0051260,GO:0051603,GO:0051716,GO:0065003,GO:0070011,GO:0070013,GO:0070887,GO:0071310,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_47942_2	323848.Nmul_A2341	4.49e-46	162.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,371ZV@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_895795_1	319795.Dgeo_1304	7.49e-81	258.0	COG0166@1|root,COG0166@2|Bacteria,1WIGN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_788685_1	760192.Halhy_4887	1.2e-45	152.0	COG4319@1|root,COG4319@2|Bacteria,4NSIN@976|Bacteroidetes	976|Bacteroidetes	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
k59_635488_2	240292.Ava_D0020	1.66e-43	149.0	2CPKU@1|root,32SJD@2|Bacteria,1G8WS@1117|Cyanobacteria,1HSH3@1161|Nostocales	1117|Cyanobacteria	L	3' exoribonuclease, RNase T-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF5051
k59_146078_1	314264.ROS217_09857	1.05e-06	51.6	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,46R08@74030|Roseovarius	28211|Alphaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_734070_2	930169.B5T_02719	5.14e-35	132.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria,1XJ4H@135619|Oceanospirillales	135619|Oceanospirillales	E	COG0520 Selenocysteine lyase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_863687_1	232348.ADXL01000051_gene2199	5.34e-20	95.1	COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria,1GZZQ@1129|Synechococcus	1117|Cyanobacteria	P	cation transport ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_178652_1	1123253.AUBD01000001_gene1704	9e-47	154.0	COG1725@1|root,COG1725@2|Bacteria,1MZG9@1224|Proteobacteria,1S993@1236|Gammaproteobacteria,1X6MY@135614|Xanthomonadales	135614|Xanthomonadales	K	GntR family transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
k59_178652_2	666685.R2APBS1_1512	1.03e-54	180.0	COG1131@1|root,COG1131@2|Bacteria,1R3XF@1224|Proteobacteria,1S0MM@1236|Gammaproteobacteria,1X3B4@135614|Xanthomonadales	135614|Xanthomonadales	V	abc transporter atp-binding protein	nodI	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_439155_1	1123487.KB892867_gene1012	2.45e-59	204.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,2KV8K@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_81155_1	94624.Bpet3654	1.11e-44	157.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,3T2I4@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_113427_1	1219031.BBJR01000055_gene2003	1.79e-39	139.0	COG1664@1|root,COG1664@2|Bacteria,1N26P@1224|Proteobacteria,2VSIS@28216|Betaproteobacteria,4AE27@80864|Comamonadaceae	28216|Betaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_505501_1	935863.AWZR01000003_gene2810	3.33e-42	152.0	COG2211@1|root,COG2211@2|Bacteria,1MWI9@1224|Proteobacteria,1RMU5@1236|Gammaproteobacteria,1X57N@135614|Xanthomonadales	135614|Xanthomonadales	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K11537	-	-	-	-	ko00000,ko02000	2.A.1.10.2	-	-	Nuc_H_symport
k59_47957_1	1123253.AUBD01000007_gene728	1.54e-52	187.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1RPJ6@1236|Gammaproteobacteria,1X4CR@135614|Xanthomonadales	135614|Xanthomonadales	M	Cellulose synthase catalytic subunit (UDP-forming)	bcsA	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	BcsB,Cellulose_synt,Glyco_hydro_17,Glyco_tranf_2_3,Glycos_transf_2,PilZ
k59_439160_1	1280954.HPO_04375	0.000219	49.7	COG3118@1|root,COG3118@2|Bacteria,1QUEA@1224|Proteobacteria	1224|Proteobacteria	O	Cellulose synthase operon	bcsC	-	-	ko:K20541,ko:K20543	-	-	-	-	ko00000,ko02000	1.B.55.3,4.D.3.1.6	-	-	BCSC_C,TPR_16,TPR_19
k59_505509_1	269797.Mbar_A1661	6.52e-132	386.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_701708_1	864051.BurJ1DRAFT_4689	7.6e-74	249.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_178671_1	330214.NIDE3307	6.3e-119	348.0	COG2813@1|root,COG2813@2|Bacteria	2|Bacteria	J	rRNA (guanine-N2-)-methyltransferase activity	crtF	GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.210,2.1.1.304,2.1.1.333	ko:K09846,ko:K13604,ko:K21460	ko00860,ko00906,ko01100,ko01110,map00860,map00906,map01100,map01110	-	R07521,R07524,R07527,R07529,R07533,R07535,R09063	RC00003,RC01662,RC02082	ko00000,ko00001,ko01000	-	-	-	Dimerisation2,Methyltransf_2,Methyltransf_25
k59_832228_1	305700.B447_04387	2.32e-83	258.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,2KUE1@206389|Rhodocyclales	206389|Rhodocyclales	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_570789_1	1415779.JOMH01000001_gene177	2.45e-06	50.8	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_404428_1	323848.Nmul_A2313	6.91e-131	389.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,371WH@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_668891_1	1123368.AUIS01000004_gene153	0.000923	47.8	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,2NCJU@225057|Acidithiobacillales	225057|Acidithiobacillales	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
k59_962559_1	1173264.KI913949_gene2028	5.31e-46	164.0	COG3385@1|root,COG3385@2|Bacteria,1G0M7@1117|Cyanobacteria,1HA8V@1150|Oscillatoriales	1117|Cyanobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_895832_1	330214.NIDE0362	8.27e-87	273.0	COG0445@1|root,COG0445@2|Bacteria,3J0E9@40117|Nitrospirae	40117|Nitrospirae	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_763468_1	483215.BACFIN_07181	1.93e-42	148.0	COG0744@1|root,COG0744@2|Bacteria,4NF90@976|Bacteroidetes,2FN8I@200643|Bacteroidia,4AMPY@815|Bacteroidaceae	976|Bacteroidetes	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_308114_1	522306.CAP2UW1_4197	5.64e-69	219.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,1KPV6@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_308114_2	765914.ThisiDRAFT_2777	1.22e-60	202.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales	135613|Chromatiales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_788701_1	1125863.JAFN01000001_gene766	3.54e-55	186.0	COG1055@1|root,COG1055@2|Bacteria,1MXKG@1224|Proteobacteria,42PAX@68525|delta/epsilon subdivisions,2WKEP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Putative citrate transport	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
k59_788701_2	1120980.JQKH01000035_gene2046	7.8e-10	58.5	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2VHK7@28216|Betaproteobacteria,2KQ8C@206351|Neisseriales	206351|Neisseriales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_580943_1	205922.Pfl01_1999	7.78e-46	162.0	2E2YT@1|root,32XZH@2|Bacteria,1MYTS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_351541_1	1031711.RSPO_c02211	3.16e-05	45.4	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,1K0GQ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_351541_2	1006004.GBAG_3523	1.09e-17	83.6	COG0565@1|root,COG0565@2|Bacteria,1MUKP@1224|Proteobacteria,1RMZX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	lasT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_317017_1	459349.CLOAM0709	1.63e-70	233.0	COG2414@1|root,COG2414@2|Bacteria,2NNME@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_156026_1	436308.Nmar_0263	8.12e-90	277.0	COG0165@1|root,arCOG01748@2157|Archaea,41S6A@651137|Thaumarchaeota	651137|Thaumarchaeota	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_905097_1	883126.HMPREF9710_04194	2.23e-26	107.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,472NW@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_351550_1	1187851.A33M_0728	3.69e-44	150.0	COG0461@1|root,COG0461@2|Bacteria,1MVP7@1224|Proteobacteria,2TTSB@28211|Alphaproteobacteria,3FCWW@34008|Rhodovulum	28211|Alphaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_25666_2	298655.KI912266_gene6134	6.7e-80	244.0	COG1028@1|root,COG1028@2|Bacteria,2GK47@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	ydaD	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_188043_1	314265.R2601_08006	6.1e-146	424.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TTWE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_478816_2	795666.MW7_2512	1.66e-63	202.0	COG1028@1|root,COG1028@2|Bacteria,1NBB6@1224|Proteobacteria,2VNXU@28216|Betaproteobacteria,1K116@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_124174_1	485915.Dret_0950	8.75e-44	150.0	2DQBG@1|root,335T7@2|Bacteria,1N795@1224|Proteobacteria,42VWE@68525|delta/epsilon subdivisions,2WRT6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	-	-	-	-	-	-	-	-	-	-	GRDB
k59_156897_1	1382230.ASAP_0268	2.15e-34	130.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2JQAF@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_646115_1	1231392.OCGS_0274	1.06e-61	204.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1004711_1	375286.mma_0873	1.93e-18	78.2	2E7PS@1|root,3325B@2|Bacteria,1PVAH@1224|Proteobacteria,2VVUK@28216|Betaproteobacteria,47552@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_58252_1	118161.KB235922_gene4299	2.25e-33	129.0	COG3386@1|root,COG3386@2|Bacteria,1G05C@1117|Cyanobacteria,3VHKB@52604|Pleurocapsales	1117|Cyanobacteria	G	PFAM SMP-30 Gluconolaconase LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_58252_2	857087.Metme_1947	3.59e-26	100.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1XF3U@135618|Methylococcales	135618|Methylococcales	S	PFAM Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_92217_1	518766.Rmar_2140	3.14e-79	245.0	COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,4NS7V@976|Bacteroidetes	976|Bacteroidetes	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_905999_1	909663.KI867150_gene725	8.37e-77	242.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MR71@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_712825_1	522306.CAP2UW1_2118	2.19e-16	84.3	COG1352@1|root,COG2201@1|root,COG3829@1|root,COG5001@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9
k59_317849_2	292415.Tbd_1946	1.86e-21	91.3	2EV5S@1|root,33NKJ@2|Bacteria,1NI0N@1224|Proteobacteria,2VYM4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3568)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3568
k59_680070_1	1504672.669785282	3.99e-26	114.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,4ABZ1@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_188937_1	1458275.AZ34_01925	6.89e-64	208.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,4AC2V@80864|Comamonadaceae	28216|Betaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_188937_2	748247.AZKH_0058	2.37e-27	106.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,2KUBC@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_352469_1	1038858.AXBA01000005_gene4451	9.24e-08	58.9	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3EYFT@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_646131_1	945713.IALB_0316	5.64e-31	114.0	COG0817@1|root,COG0817@2|Bacteria	2|Bacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_646131_2	1122603.ATVI01000007_gene1452	7.45e-21	89.4	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1X373@135614|Xanthomonadales	135614|Xanthomonadales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_250600_2	530564.Psta_3689	4.12e-62	199.0	COG0177@1|root,COG0177@2|Bacteria,2IYYT@203682|Planctomycetes	203682|Planctomycetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_680079_1	526227.Mesil_1017	2.69e-06	48.1	COG0395@1|root,COG0395@2|Bacteria,1WMEG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_680079_2	55529.EKX50650	1.63e-19	90.9	COG0673@1|root,KOG2741@2759|Eukaryota	2759|Eukaryota	V	D-xylose 1-dehydrogenase (NADP+) activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_581928_1	1280948.HY36_04770	1.62e-32	132.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,43WD4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_613792_1	159087.Daro_3062	6.86e-131	377.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2VIC9@28216|Betaproteobacteria,2KV79@206389|Rhodocyclales	206389|Rhodocyclales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_317863_1	1121380.JNIW01000014_gene2412	2.93e-25	106.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	sthA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_58275_1	713586.KB900536_gene1501	9.2e-71	227.0	COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,1S09M@1236|Gammaproteobacteria,1X09N@135613|Chromatiales	135613|Chromatiales	OQ	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_773160_1	330214.NIDE0245	5.6e-126	372.0	COG0260@1|root,COG0260@2|Bacteria,3J0X7@40117|Nitrospirae	40117|Nitrospirae	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_773161_1	1266925.JHVX01000005_gene1861	2.03e-62	214.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,371QF@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_92243_1	1121374.KB891575_gene800	1.02e-09	65.1	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_8
k59_352492_1	76114.ebA4343	6.16e-58	187.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,2KVU7@206389|Rhodocyclales	206389|Rhodocyclales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_352492_2	1218076.BAYB01000035_gene5278	1.78e-27	105.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2VR8K@28216|Betaproteobacteria,1K2YJ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_516552_2	330214.NIDE0360	1.96e-81	258.0	COG0706@1|root,COG0706@2|Bacteria,3J0GD@40117|Nitrospirae	40117|Nitrospirae	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1004748_1	926551.KB900736_gene1241	9.51e-05	43.1	COG1277@1|root,COG1277@2|Bacteria,4NG5G@976|Bacteroidetes,1HX1M@117743|Flavobacteriia,1EQE6@1016|Capnocytophaga	976|Bacteroidetes	S	gliding motility-associated ABC transporter permease protein GldF	gldF	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_1004748_2	83406.HDN1F_28550	1.04e-19	93.2	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	transport system involved in gliding motility, auxiliary component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_279657_1	622637.KE124774_gene1612	1.92e-09	62.0	COG3659@1|root,COG3659@2|Bacteria,1N12D@1224|Proteobacteria,2UDX5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
k59_680097_1	326424.FRAAL0854	1.05e-24	101.0	COG5078@1|root,COG5078@2|Bacteria	2|Bacteria	O	protein modification by small protein conjugation	-	-	-	-	-	-	-	-	-	-	-	-	ThiF,UQ_con,Yop-YscD_cpl
k59_646153_1	525146.Ddes_2138	7.83e-58	202.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K07789,ko:K18138	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00647,M00648,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_449593_1	1191460.F959_02370	3.69e-63	200.0	COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,1RS58@1236|Gammaproteobacteria,3NP2B@468|Moraxellaceae	1236|Gammaproteobacteria	L	ISXO2-like transposase domain	-	-	-	ko:K07488	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1595
k59_646155_1	1449126.JQKL01000019_gene3246	4.21e-15	76.6	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,268RD@186813|unclassified Clostridiales	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_646155_2	196367.JNFG01000008_gene6508	5.22e-12	65.9	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,2VQSK@28216|Betaproteobacteria,1K5XP@119060|Burkholderiaceae	28216|Betaproteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_413946_1	247634.GPB2148_1649	5.21e-42	159.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1J4NA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretory pathway component ExeA	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1,T2SSB
k59_581949_1	420662.Mpe_A1298	5.31e-15	77.8	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,1KITG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_1004754_1	395493.BegalDRAFT_0765	7.06e-88	265.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,45ZWH@72273|Thiotrichales	72273|Thiotrichales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_745293_2	436308.Nmar_1263	1.38e-35	125.0	COG2097@1|root,arCOG04473@2157|Archaea,41STQ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the ribosomal protein L31e family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
k59_906041_2	398579.Spea_3295	2.36e-09	61.6	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,2Q9MA@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_317890_2	1532558.JL39_28350	1.75e-36	126.0	COG2337@1|root,COG2337@2|Bacteria,1MZAV@1224|Proteobacteria,2UD15@28211|Alphaproteobacteria,4BGI3@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Growth inhibitor	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
k59_221486_1	883080.HMPREF9697_00485	6.75e-23	95.9	2AIUQ@1|root,319BW@2|Bacteria,1NS01@1224|Proteobacteria,2UNM6@28211|Alphaproteobacteria,3K2I7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_279667_1	436308.Nmar_0483	1.58e-45	153.0	COG1117@1|root,arCOG00231@2157|Archaea,41SYJ@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_279667_2	436308.Nmar_0484	3.99e-74	226.0	COG0704@1|root,arCOG00232@2157|Archaea,41T42@651137|Thaumarchaeota	651137|Thaumarchaeota	P	PhoU domain	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_221488_1	1500301.JQMF01000011_gene2453	1.45e-31	127.0	COG1132@1|root,COG4988@1|root,COG1132@2|Bacteria,COG4988@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,4BAKA@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter	-	-	-	ko:K02021	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran,cNMP_binding
k59_317896_1	1254432.SCE1572_17400	7.04e-27	107.0	COG1028@1|root,COG1028@2|Bacteria,1MW4W@1224|Proteobacteria,43DGY@68525|delta/epsilon subdivisions,2X8NT@28221|Deltaproteobacteria,2YUWT@29|Myxococcales	28221|Deltaproteobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_317896_2	519989.ECTPHS_03272	1.8e-74	245.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales	135613|Chromatiales	C	PFAM malic	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_188986_1	1005999.GLGR_2438	5.92e-71	225.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,1S1A5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1004777_1	391625.PPSIR1_34667	6.86e-32	120.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42URE@68525|delta/epsilon subdivisions,2WR5V@28221|Deltaproteobacteria,2YY8T@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_384093_1	1121405.dsmv_3479	1.22e-14	72.4	COG1028@1|root,COG1028@2|Bacteria,1MUWP@1224|Proteobacteria,43AXS@68525|delta/epsilon subdivisions,2X6BX@28221|Deltaproteobacteria,2MNSI@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_413965_1	743299.Acife_2468	5.85e-27	102.0	COG0509@1|root,COG0509@2|Bacteria,1N2U9@1224|Proteobacteria,1SC71@1236|Gammaproteobacteria,2NCVY@225057|Acidithiobacillales	225057|Acidithiobacillales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_413965_2	243159.AFE_2548	6.6e-53	170.0	COG2044@1|root,COG2044@2|Bacteria,1N7MM@1224|Proteobacteria,1SCQA@1236|Gammaproteobacteria,2NCTS@225057|Acidithiobacillales	225057|Acidithiobacillales	S	DsrE/DsrF-like family	-	-	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE
k59_712888_1	883.DvMF_2608	4.45e-58	190.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42NUE@68525|delta/epsilon subdivisions,2WJYH@28221|Deltaproteobacteria,2MGJN@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_941106_1	504832.OCAR_4913	9.24e-59	193.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,3JTI5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	cation efflux	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
k59_843525_1	573370.DMR_20450	3.36e-28	117.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_712897_1	794903.OPIT5_29135	1.75e-54	187.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,46UC6@74201|Verrucomicrobia,3K7A8@414999|Opitutae	414999|Opitutae	C	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_26666_1	1121403.AUCV01000010_gene1423	1.05e-32	127.0	COG5433@1|root,COG5433@2|Bacteria,1MXI8@1224|Proteobacteria,42WFU@68525|delta/epsilon subdivisions,2WS4T@28221|Deltaproteobacteria,2MKX1@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Pfam Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_941121_1	987059.RBXJA2T_18989	3.76e-158	458.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,1KITK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_793105_1	323848.Nmul_A0210	6.29e-123	364.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,37240@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_156987_1	1333998.M2A_0911	5.39e-64	209.0	COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,2TYCG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_124290_1	85643.Tmz1t_2955	9.47e-54	184.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,2KY1I@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_815662_1	436308.Nmar_0729	1.48e-68	213.0	COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_815737_1	1123393.KB891328_gene590	6.07e-42	155.0	COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMT1@28216|Betaproteobacteria,1KSY9@119069|Hydrogenophilales	119069|Hydrogenophilales	NU	Secretin and TonB N terminus short domain	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
k59_815822_1	1454004.AW11_02923	1.08e-33	124.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2VJKH@28216|Betaproteobacteria	28216|Betaproteobacteria	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
k59_815828_1	1121428.DESHY_60270___1	4.6e-07	52.4	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,260MI@186807|Peptococcaceae	186801|Clostridia	T	PFAM PhoH family protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_815831_1	1459636.NTE_02920	6.76e-63	204.0	COG1236@1|root,arCOG00545@2157|Archaea,41SYB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
k59_815874_1	1288494.EBAPG3_5570	6.84e-116	349.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,371S3@32003|Nitrosomonadales	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_815927_1	267608.RSp0665	1.98e-40	144.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2VHCH@28216|Betaproteobacteria,1JZUF@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_815937_1	391625.PPSIR1_31178	5.68e-57	190.0	COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,4355G@68525|delta/epsilon subdivisions,2WZGD@28221|Deltaproteobacteria,2Z237@29|Myxococcales	28221|Deltaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_815960_1	1114970.PSF113_3475	7e-39	137.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,1RQ8V@1236|Gammaproteobacteria,1YTQ0@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Amidohydrolase	-	-	3.1.1.57	ko:K10221	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R04277	RC03110	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_815982_1	903818.KI912269_gene335	9.68e-82	254.0	COG0538@1|root,COG0538@2|Bacteria	2|Bacteria	C	isocitrate dehydrogenase activity	icd	GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_815991_1	580332.Slit_0364	1.17e-38	142.0	COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,2VJ3A@28216|Betaproteobacteria,44W5T@713636|Nitrosomonadales	28216|Betaproteobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,FabA
k59_489785_1	1089551.KE386572_gene2515	4.39e-61	194.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2TTGT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase	-	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
k59_555093_1	1395587.P364_0128545	2.95e-07	56.6	COG0739@1|root,COG4870@1|root,COG0739@2|Bacteria,COG4870@2|Bacteria,1V236@1239|Firmicutes,4HK9V@91061|Bacilli,26ZBY@186822|Paenibacillaceae	91061|Bacilli	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
k59_65315_1	767817.Desgi_2405	3.34e-28	116.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,261BW@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_489788_1	1459636.NTE_00104	1.37e-86	265.0	COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_32668_1	1392540.P256_00138	1.7e-19	85.9	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,3NK8T@468|Moraxellaceae	1236|Gammaproteobacteria	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_32668_2	1175306.GWL_16050	7.34e-34	122.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,4733Y@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_457140_1	1380394.JADL01000001_gene2940	1.95e-09	57.4	COG0066@1|root,COG0066@2|Bacteria,1RBRQ@1224|Proteobacteria,2UA0M@28211|Alphaproteobacteria,2JXDY@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the LeuD family	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_457140_2	666509.RCA23_c08370	0.000113	48.9	COG0730@1|root,COG0730@2|Bacteria,1RF06@1224|Proteobacteria,2U7EW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_32672_1	420324.KI912086_gene7356	1.16e-42	148.0	COG1225@1|root,COG1225@2|Bacteria,1N86B@1224|Proteobacteria,2TVN1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_555106_1	159087.Daro_0316	4.49e-46	163.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,2KUP0@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_555106_2	1144342.PMI40_02554	2.06e-57	188.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,472X9@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_359188_1	686340.Metal_0248	9.88e-14	71.6	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,1S4UH@1236|Gammaproteobacteria,1XEJU@135618|Methylococcales	135618|Methylococcales	S	Mut7-C ubiquitin	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C,Ub-Mut7C
k59_359188_2	1120999.JONM01000001_gene1448	2.03e-15	72.0	COG5572@1|root,COG5572@2|Bacteria	2|Bacteria	S	Predicted integral membrane protein (DUF2282)	RSP1034	-	-	-	-	-	-	-	-	-	-	-	DUF2282
k59_359188_3	1163407.UU7_15520	4.03e-59	193.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1X35S@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
k59_228587_1	301.JNHE01000011_gene3663	3.88e-23	103.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RR1B@1236|Gammaproteobacteria,1YDPN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_783655_1	706587.Desti_5091	2.73e-10	67.4	COG2204@1|root,COG4251@1|root,COG2204@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,42RAK@68525|delta/epsilon subdivisions,2WJRA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
k59_555111_2	296591.Bpro_2274	2.78e-46	155.0	COG0600@1|root,COG0600@2|Bacteria,1MVD2@1224|Proteobacteria,2VI9N@28216|Betaproteobacteria,4AC9H@80864|Comamonadaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_326551_1	1449351.RISW2_19270	5.71e-08	56.6	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,4KKC1@93682|Roseivivax	28211|Alphaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_620414_1	945713.IALB_0908	2.61e-53	171.0	COG0049@1|root,COG0049@2|Bacteria	2|Bacteria	J	rRNA binding	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_620414_2	309807.SRU_1032	2.1e-50	176.0	COG0480@1|root,COG0480@2|Bacteria,4NE9X@976|Bacteroidetes,1FIQD@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_32687_1	1469245.JFBG01000052_gene2167	5.27e-81	247.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,1RMK8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Branched-chain amino acid transport	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_718379_1	1323663.AROI01000003_gene2178	7.59e-70	219.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_391857_1	497321.C664_10752	1e-89	281.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KUWX@206389|Rhodocyclales	206389|Rhodocyclales	I	Poly(R)-hydroxyalkanoic acid synthase, class I	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PhaC_N
k59_97998_1	706587.Desti_1075	3.75e-85	279.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_718386_1	1485544.JQKP01000001_gene1165	4.56e-43	160.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,44VNU@713636|Nitrosomonadales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD4	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_881639_1	1288494.EBAPG3_30010	8.14e-42	137.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU9X@28216|Betaproteobacteria,373F5@32003|Nitrosomonadales	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_881639_2	376619.FTL_0257	2.39e-15	68.2	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,1SGC9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
k59_881639_3	283942.IL1894	5.92e-49	159.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,2QG4C@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_457167_1	522306.CAP2UW1_1749	9.65e-113	331.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_293918_1	1137268.AZXF01000045_gene964	1.45e-15	82.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EJT5@85012|Streptosporangiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_293918_2	517418.Ctha_1450	3.98e-05	47.4	COG5433@1|root,COG5433@2|Bacteria	2|Bacteria	L	transposase activity	tnp4	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_261283_1	1229909.NSED_03085	1e-11	64.3	COG0530@1|root,arCOG02881@2157|Archaea,41T1S@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_261283_2	1229909.NSED_03080	3.73e-62	191.0	arCOG10530@1|root,arCOG10530@2157|Archaea,41T2M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_620442_1	2340.JV46_04030	1.14e-53	174.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1S237@1236|Gammaproteobacteria,1J9MC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_979621_2	452637.Oter_0294	9.98e-53	169.0	COG3370@1|root,COG3370@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_881652_1	1231241.Mc24_04155	2.4e-91	279.0	COG0050@1|root,COG0050@2|Bacteria,2GCEB@200918|Thermotogae	200918|Thermotogae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_718399_1	1234364.AMSF01000018_gene1411	3.29e-42	151.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_65376_1	1444770.AF72_00145	3.39e-58	193.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1X3F0@135614|Xanthomonadales	135614|Xanthomonadales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_816364_1	76114.ebA3572	3.95e-46	151.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,2KX0I@206389|Rhodocyclales	206389|Rhodocyclales	P	protein involved in tolerance to divalent cations	cutA1	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
k59_946975_1	1528106.JRJE01000008_gene1554	2.02e-19	91.7	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2JRGA@204441|Rhodospirillales	204441|Rhodospirillales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_587812_1	1158292.JPOE01000002_gene1575	3.46e-63	211.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VJQV@28216|Betaproteobacteria,1KKI1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_685766_1	1173029.JH980292_gene4020	4.26e-07	53.5	COG2208@1|root,COG2208@2|Bacteria,1G0BD@1117|Cyanobacteria,1H7CV@1150|Oscillatoriales	1117|Cyanobacteria	KT	Serine phosphatase RsbU regulator of sigma subunit	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
k59_685766_2	457425.XNR_0734	4.22e-10	60.1	COG1716@1|root,COG1716@2|Bacteria,2HPF7@201174|Actinobacteria	201174|Actinobacteria	T	(FHA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707,FHA
k59_195988_1	644801.Psest_1263	2.18e-75	239.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1Z1SX@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	histidyl-tRNA synthetase	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	HGTP_anticodon,tRNA-synt_His
k59_359233_1	292415.Tbd_1644	6.33e-11	60.1	2E5B5@1|root,33039@2|Bacteria,1NDK8@1224|Proteobacteria,2W5JF@28216|Betaproteobacteria,1KT7E@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_359233_2	1123392.AQWL01000008_gene1153	4.12e-143	410.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,2VV9S@28216|Betaproteobacteria,1KSCV@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_228633_1	1231391.AMZF01000009_gene1763	1.91e-22	103.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,2VH0U@28216|Betaproteobacteria,3T26S@506|Alcaligenaceae	28216|Betaproteobacteria	J	Translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_391892_1	1121035.AUCH01000014_gene2358	9.88e-59	200.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,2KV0U@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional activator of acetoin glycerol metabolism	-	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
k59_522512_1	1396141.BATP01000003_gene5276	3.05e-37	139.0	COG0477@1|root,COG2814@2|Bacteria,46U6X@74201|Verrucomicrobia,2IV79@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_685768_1	1304888.ATWF01000001_gene1784	1.93e-13	68.2	COG0296@1|root,COG0296@2|Bacteria,2GFUK@200930|Deferribacteres	200930|Deferribacteres	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
k59_685768_2	1265505.ATUG01000003_gene639	1.87e-25	98.6	2ENER@1|root,33G27@2|Bacteria,1NGAB@1224|Proteobacteria,42WZZ@68525|delta/epsilon subdivisions,2WTCF@28221|Deltaproteobacteria,2MMEF@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_228634_1	1123060.JONP01000008_gene4482	1.68e-19	90.9	COG2834@1|root,COG4261@1|root,COG2834@2|Bacteria,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,2U2W1@28211|Alphaproteobacteria,2JQ7Y@204441|Rhodospirillales	204441|Rhodospirillales	M	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Lip_A_acyltrans
k59_228634_2	426114.THI_2603	2.24e-22	94.4	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,2VHP0@28216|Betaproteobacteria,1KNCT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
k59_620457_1	622637.KE124774_gene1454	1.92e-149	433.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	arylsulfatase A	aslA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_751055_1	62928.azo3740	4.08e-195	552.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,2KVBV@206389|Rhodocyclales	206389|Rhodocyclales	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_751055_2	1245471.PCA10_12130	8.02e-28	108.0	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,1RN6Q@1236|Gammaproteobacteria,1YD1H@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
k59_653133_1	543632.JOJL01000121_gene9849	7.51e-86	268.0	COG1321@1|root,COG1321@2|Bacteria,2GN2R@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_391905_1	1232437.KL662000_gene4759	2.65e-43	150.0	COG2203@1|root,COG2203@2|Bacteria,1R8AK@1224|Proteobacteria,42MTP@68525|delta/epsilon subdivisions,2WIST@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
k59_856546_1	1502770.JQMG01000001_gene1416	1.78e-46	166.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,2KKPI@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_301304_1	1042377.AFPJ01000020_gene2062	1.14e-106	325.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_106042_1	1218076.BAYB01000014_gene3018	3.04e-65	204.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,1K1JA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the UPF0234 family	yajQ	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_398362_1	472759.Nhal_2913	4.24e-53	187.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,1X03G@135613|Chromatiales	135613|Chromatiales	G	Fatty acid cis/trans isomerase (CTI)	-	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_786114_2	694431.DESACE_05845	8.76e-10	60.1	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria,2M6ZZ@213113|Desulfurellales	28221|Deltaproteobacteria	E	Chorismate mutase type II	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_203811_1	7668.SPU_005429-tr	6.62e-50	181.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta	33154|Opisthokonta	G	retrotransposable element Tf2 155 kDa protein type 1-like	-	-	-	-	-	-	-	-	-	-	-	-	PNMA,RVT_1,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_463500_1	1353531.AZNX01000010_gene1192	2.59e-16	81.3	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TRZE@28211|Alphaproteobacteria,4B71Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_107122_1	697282.Mettu_1399	7.29e-27	100.0	COG2921@1|root,COG2921@2|Bacteria,1PJDX@1224|Proteobacteria,1THTC@1236|Gammaproteobacteria,1XFN8@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0250 family	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
k59_596802_1	1123261.AXDW01000001_gene1371	2.53e-54	191.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1X6T3@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,HAMP,Pkinase,sCache_3_2
k59_758251_1	436308.Nmar_0386	1.36e-76	230.0	COG0250@1|root,arCOG01920@2157|Archaea,41SM6@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
k59_139798_1	945713.IALB_0399	3.71e-31	120.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
k59_9351_1	478749.BRYFOR_07606	1.67e-37	140.0	COG4383@1|root,COG4383@2|Bacteria,1TS7T@1239|Firmicutes,24CCB@186801|Clostridia	186801|Clostridia	S	Mu-like prophage protein gp29	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_596804_1	556268.OFAG_02107	3.28e-181	514.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VNWB@28216|Betaproteobacteria,478EE@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_662387_1	926569.ANT_20890	3.7e-41	151.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_270280_1	670292.JH26_02250	2.89e-125	367.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,1JRXN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_889803_1	756067.MicvaDRAFT_5451	1.35e-27	118.0	COG1361@1|root,COG2931@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1G463@1117|Cyanobacteria,1H97Y@1150|Oscillatoriales	1117|Cyanobacteria	MQ	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,SdrD_B
k59_727570_1	257313.BP3539	2.76e-84	260.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,3T5IW@506|Alcaligenaceae	28216|Betaproteobacteria	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_988079_1	555079.Toce_0906	1.24e-38	141.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,42F85@68295|Thermoanaerobacterales	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_433109_1	85643.Tmz1t_2548	1.25e-141	416.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,2KV73@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_433109_2	1288494.EBAPG3_15750	6.43e-46	151.0	COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,373DV@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_433109_3	76114.ebD20	8.03e-49	159.0	COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,2VSEG@28216|Betaproteobacteria,2KWKD@206389|Rhodocyclales	206389|Rhodocyclales	C	COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_433109_4	666681.M301_0692	2.44e-12	65.9	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VJ6N@28216|Betaproteobacteria,2KM9E@206350|Nitrosomonadales	206350|Nitrosomonadales	K	PFAM UbiC transcription regulator-associated domain protein	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
k59_727575_1	247639.MGP2080_05687	4.83e-32	126.0	28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria,1J5EM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_74711_1	665571.STHERM_c19340	4.84e-82	251.0	COG1136@1|root,COG1136@2|Bacteria,2J6R3@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_528553_1	103690.17135536	2.41e-67	231.0	COG0642@1|root,COG0784@1|root,COG1196@1|root,COG1352@1|root,COG2201@1|root,COG0784@2|Bacteria,COG1196@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HIYG@1161|Nostocales	1117|Cyanobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS_10,PAS_4,Response_reg
k59_367946_1	159087.Daro_1290	2.31e-38	141.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2VJ8C@28216|Betaproteobacteria,2KVHU@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_367946_3	292415.Tbd_1000	1.38e-27	106.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,1KTBK@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Small MutS-related domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_335516_1	713586.KB900536_gene1496	2.09e-08	55.1	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1WXK9@135613|Chromatiales	135613|Chromatiales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_335516_2	883126.HMPREF9710_02704	9.57e-108	314.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,472VR@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, mono-heme subunit/FixO	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_204867_1	314287.GB2207_02855	1.7e-49	176.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1RYC0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Outer membrane receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_367955_1	330214.NIDE2035	1.34e-102	309.0	COG1253@1|root,COG1253@2|Bacteria,3J0KN@40117|Nitrospirae	40117|Nitrospirae	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_399341_1	96561.Dole_1729	3.77e-107	333.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2MHQG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_857663_1	269482.Bcep1808_4891	9.21e-121	372.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VJKJ@28216|Betaproteobacteria,1K04G@119060|Burkholderiaceae	28216|Betaproteobacteria	M	penicillin-binding protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_399350_1	1047013.AQSP01000137_gene563	1.69e-13	69.7	COG0674@1|root,COG0674@2|Bacteria,2NNWT@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	vorB	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_172427_1	305700.B447_15356	4.62e-35	123.0	COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,2KWK5@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinate dehydrogenase, hydrophobic	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_889842_1	589865.DaAHT2_0414	2.09e-39	147.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_74742_2	497321.C664_03045	4.76e-52	176.0	COG2239@1|root,COG2239@2|Bacteria,1NQNA@1224|Proteobacteria	1224|Proteobacteria	P	Divalent cation transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE
k59_433154_1	1123229.AUBC01000007_gene187	9.76e-35	130.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U401@28211|Alphaproteobacteria,3JW1T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_270334_1	1229909.NSED_09050	1.07e-111	329.0	COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ATP synthase (C/AC39) subunit	-	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
k59_270337_1	1229909.NSED_09195	4.01e-16	78.6	COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota	651137|Thaumarchaeota	S	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
k59_596877_1	926569.ANT_00760	1.25e-28	109.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_956079_1	997346.HMPREF9374_2361	8.04e-17	80.9	COG0281@1|root,COG0281@2|Bacteria,1UYHB@1239|Firmicutes,4HDRG@91061|Bacilli,27B6W@186824|Thermoactinomycetaceae	91061|Bacilli	C	Malic enzyme, N-terminal domain	mleA	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C,ACT_4,Malic_M,THF_DHG_CYH_C,malic
k59_956079_2	29486.NJ56_00980	1.07e-36	134.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,41FC6@629|Yersinia	1236|Gammaproteobacteria	K	factor RpoH	rpoH	GO:0000150,GO:0000976,GO:0000984,GO:0000985,GO:0000988,GO:0000990,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006310,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009009,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031421,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2001141	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_204911_1	351348.Maqu_0609	2.25e-58	193.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,1RRNV@1236|Gammaproteobacteria,46D6X@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32,HTH_33
k59_399375_1	1245471.PCA10_03330	2.89e-15	80.1	COG2199@1|root,COG3706@2|Bacteria,1QJQR@1224|Proteobacteria,1RR97@1236|Gammaproteobacteria,1YCUJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	pleD_1	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_4
k59_956087_1	1504672.669786338	1.02e-85	265.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,4AB40@80864|Comamonadaceae	28216|Betaproteobacteria	S	DinB superfamily	egtB	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_139886_1	1038860.AXAP01000018_gene3057	9.42e-08	55.1	COG3181@1|root,COG3181@2|Bacteria,1R4FE@1224|Proteobacteria,2TVEG@28211|Alphaproteobacteria,3JRWF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_139886_2	316056.RPC_4304	3.55e-52	176.0	COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,3JT2K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	MA20_20705	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_727647_1	1094508.Tsac_2202	1.21e-11	69.7	COG0477@1|root,COG2814@2|Bacteria,1UM9R@1239|Firmicutes,2486D@186801|Clostridia,42J86@68295|Thermoanaerobacterales	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_270356_1	522306.CAP2UW1_0261	1.29e-148	427.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,1KQI7@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320,ko:K06580	-	-	-	-	ko00000,ko02000,ko04090	1.A.11,1.A.11.4	-	-	Ammonium_transp
k59_956098_1	1492737.FEM08_09470	3.55e-05	47.4	2ATWF@1|root,31JFP@2|Bacteria,4NT3Q@976|Bacteroidetes,1ICNG@117743|Flavobacteriia,2NTSD@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_956098_2	909663.KI867150_gene313	7.22e-44	149.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,42RV4@68525|delta/epsilon subdivisions,2WP4W@28221|Deltaproteobacteria,2MRS3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_727653_2	702113.PP1Y_AT16989	5.32e-78	238.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,2K0IE@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_499260_2	1123354.AUDR01000013_gene708	3.78e-28	116.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,1KS47@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_923665_1	748247.AZKH_4600	3.22e-42	149.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,2KV57@206389|Rhodocyclales	206389|Rhodocyclales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2
k59_923665_2	1101195.Meth11DRAFT_0244	1.64e-55	193.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,2KKR4@206350|Nitrosomonadales	206350|Nitrosomonadales	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_7
k59_368012_1	439235.Dalk_1993	2.74e-47	159.0	COG0789@1|root,COG0789@2|Bacteria,1N7M7@1224|Proteobacteria,42WAT@68525|delta/epsilon subdivisions,2WRPH@28221|Deltaproteobacteria,2MMFX@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM regulatory protein MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_499274_1	194867.ALBQ01000023_gene3231	0.00042	48.1	COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,2U5G9@28211|Alphaproteobacteria,2JZWU@204457|Sphingomonadales	204457|Sphingomonadales	M	salt-induced outer membrane protein	-	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF481
k59_236130_1	1255043.TVNIR_3249	1.71e-44	149.0	COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,1SMDU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
k59_956126_1	292415.Tbd_1128	2.08e-150	453.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1KSTH@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_596926_1	1485544.JQKP01000001_gene1112	1.76e-23	91.7	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,44VXD@713636|Nitrosomonadales	28216|Betaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_596926_2	667632.KB890170_gene3782	2.3e-72	224.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,1K0IX@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_923698_2	323848.Nmul_A0670	6.02e-83	270.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,3729D@32003|Nitrosomonadales	28216|Betaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_727699_1	269797.Mbar_A1661	2.42e-98	297.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_9496_1	1265502.KB905931_gene1657	3.9e-79	240.0	COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,2VMIW@28216|Betaproteobacteria,4ABCK@80864|Comamonadaceae	28216|Betaproteobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_1016292_1	314287.GB2207_12002	1.41e-40	149.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria,1J7RY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_662532_1	373903.Hore_08380	2.76e-18	85.9	COG4758@1|root,COG4758@2|Bacteria,1VE20@1239|Firmicutes,24J2R@186801|Clostridia,3WBSM@53433|Halanaerobiales	186801|Clostridia	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
k59_236148_2	1288826.MSNKSG1_00581	3.16e-26	97.4	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,467T8@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_172537_1	1163617.SCD_n01884	6.98e-23	96.3	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,2VUBQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Glucose inhibited division protein A	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored
k59_302447_1	450851.PHZ_c2248	1.82e-51	174.0	COG0625@1|root,COG0625@2|Bacteria,1Q9ND@1224|Proteobacteria,2TT22@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0625 Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
k59_706586_1	1288494.EBAPG3_13660	8.01e-95	285.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,3727I@32003|Nitrosomonadales	28216|Betaproteobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_790606_1	401526.TcarDRAFT_2338	4.46e-14	70.9	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4H3WK@909932|Negativicutes	909932|Negativicutes	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
k59_673769_2	338969.Rfer_3093	3.48e-67	209.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,4AF23@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	padC	-	-	ko:K08358,ko:K18362,ko:K21308	ko00360,ko00920,ko01100,ko01120,ko02020,map00360,map00920,map01100,map01120,map02020	-	R07222,R07294,R10150,R11487	RC00004,RC00168,RC01844,RC01903,RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Fer4_11,Fer4_4,Fer4_7
k59_673772_1	1144325.PMI22_00608	3.78e-83	262.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_900202_1	1036674.A28LD_0242	1.78e-34	124.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,2QFIA@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_900202_2	999141.GME_13330	4.6e-52	164.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1XK9W@135619|Oceanospirillales	135619|Oceanospirillales	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_118240_1	436308.Nmar_0724	2.27e-58	186.0	arCOG05906@1|root,arCOG05906@2157|Archaea,41T21@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_607789_1	153948.NAL212_0269	1.47e-74	242.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,371T2@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_739025_1	7029.ACYPI085336-PA	1.92e-39	149.0	COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa,3D40D@33213|Bilateria,4222J@6656|Arthropoda,3SQHH@50557|Insecta	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_346460_1	864051.BurJ1DRAFT_1416	6.54e-44	150.0	COG2010@1|root,COG2010@2|Bacteria,1RBTK@1224|Proteobacteria,2WEJM@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_837137_1	481448.Minf_0829	1.45e-44	156.0	28I4Y@1|root,2Z88D@2|Bacteria,46VRF@74201|Verrucomicrobia,37GMA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_967442_1	1121875.KB907546_gene2208	2.26e-35	134.0	COG1680@1|root,COG1680@2|Bacteria,4PI69@976|Bacteroidetes,1I0GH@117743|Flavobacteriia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_967442_2	1205908.AKXW01000045_gene3643	2.41e-07	52.8	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQV@1236|Gammaproteobacteria,1XSBM@135623|Vibrionales	135623|Vibrionales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_215633_1	296591.Bpro_4149	2.63e-76	251.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,4AAXQ@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_215633_2	296591.Bpro_4148	4.92e-20	82.0	2DNR5@1|root,32YQH@2|Bacteria,1NBXJ@1224|Proteobacteria,2VW7K@28216|Betaproteobacteria,4AIUC@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_868525_1	987059.RBXJA2T_17756	3.05e-85	259.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,1KIUQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_150937_1	159087.Daro_0189	3.2e-09	57.8	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,2VKN0@28216|Betaproteobacteria,2KUY8@206389|Rhodocyclales	206389|Rhodocyclales	M	acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_150937_2	1163617.SCD_n00308	2.01e-94	295.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Lipid A Biosynthesis	htrB	-	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_640162_1	1205680.CAKO01000030_gene4944	1.07e-46	160.0	COG0596@1|root,COG0596@2|Bacteria,1NDHC@1224|Proteobacteria,2UPRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_118261_1	395964.KE386496_gene2166	6.11e-47	167.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,3NAC7@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_86015_1	96561.Dole_1461	1.07e-48	171.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MINQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_998936_1	521719.ATXQ01000001_gene617	1.43e-07	52.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1YEMW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Branched-chain amino acid ATP-binding cassette transporter	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_998936_2	83406.HDN1F_06310	5.93e-19	87.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1J4HB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_934866_1	497321.C664_07253	7.15e-82	258.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUGM@206389|Rhodocyclales	206389|Rhodocyclales	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_52575_1	411460.RUMTOR_01333	1.27e-54	183.0	28K55@1|root,2Z9TX@2|Bacteria,1V0P7@1239|Firmicutes,24DCX@186801|Clostridia,3Y0KI@572511|Blautia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Sipho_Gp37
k59_739066_1	323848.Nmul_A2455	9.66e-34	121.0	COG3087@1|root,COG3087@2|Bacteria,1RIU5@1224|Proteobacteria,2VTKT@28216|Betaproteobacteria,3731K@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_739066_2	1123392.AQWL01000013_gene2388	5.39e-12	65.5	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,1KRUW@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_510343_2	335283.Neut_0617	3.41e-28	104.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,2VTX5@28216|Betaproteobacteria,373IS@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_575625_1	330084.JNYZ01000060_gene2897	3.58e-14	72.8	2CQ1K@1|root,32SKA@2|Bacteria	2|Bacteria	S	membrane	MA20_15810	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
k59_510348_1	883078.HMPREF9695_01596	6.07e-90	275.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria,3JZX1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_510348_2	644968.DFW101_0779	1.26e-06	49.7	COG3324@1|root,COG3324@2|Bacteria,1N9ZV@1224|Proteobacteria,430FM@68525|delta/epsilon subdivisions,2WW69@28221|Deltaproteobacteria,2MBS4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_640189_1	439235.Dalk_0339	3.42e-36	141.0	COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42YZ2@68525|delta/epsilon subdivisions,2WTQ1@28221|Deltaproteobacteria,2MPM0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02668,ko:K07709	ko02020,map02020	M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_10,PAS_4,PAS_9,sCache_3_2
k59_346509_1	1121878.AUGL01000021_gene2815	4.05e-79	254.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_150968_1	290397.Adeh_3081	3.49e-80	257.0	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,42NVR@68525|delta/epsilon subdivisions,2WM9A@28221|Deltaproteobacteria,2YU0T@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_673844_1	56780.SYN_02220	7.36e-67	213.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,2MQGV@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Oxidoreductase NAD-binding domain	hyhG	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
k59_575634_1	1278073.MYSTI_03498	8.27e-19	89.4	COG4191@1|root,COG4191@2|Bacteria,1NV4N@1224|Proteobacteria,42ZK7@68525|delta/epsilon subdivisions,2WV0W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_575634_2	1121405.dsmv_2330	2.23e-09	57.8	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIQF@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_312464_1	292415.Tbd_0619	4.83e-114	342.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,1KRHJ@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_706644_1	238854.Q5GQF2_BPSYP	5.08e-82	255.0	4QAM2@10239|Viruses,4QV3W@35237|dsDNA viruses  no RNA stage,4QPGK@28883|Caudovirales,4QIRV@10662|Myoviridae	10662|Myoviridae	S	5'-3' exonuclease, N-terminal resolvase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_706644_2	1357423.S5MD71_9CAUD	1.14e-16	80.5	4QD8M@10239|Viruses,4QZGV@35237|dsDNA viruses  no RNA stage,4QU5A@28883|Caudovirales,4QJQD@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_706644_6	268747.Q58LA1_BPPRS	2.97e-65	210.0	4QCHF@10239|Viruses,4QW57@35237|dsDNA viruses  no RNA stage,4QPIH@28883|Caudovirales,4QHVS@10662|Myoviridae	10662|Myoviridae	S	PhoH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_706644_7	1283076.M1I833_9CAUD	6.72e-31	120.0	4QC7D@10239|Viruses,4R0G1@35237|dsDNA viruses  no RNA stage,4QPET@28883|Caudovirales,4QJJ1@10662|Myoviridae	10662|Myoviridae	S	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_20623_1	1265502.KB905969_gene1242	7.35e-07	50.1	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,2VI8P@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_20623_2	1502770.JQMG01000001_gene725	4.86e-65	204.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2VMPA@28216|Betaproteobacteria,2KKRF@206350|Nitrosomonadales	206350|Nitrosomonadales	Q	TIGRFAM methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
k59_510367_1	88036.EFJ21685	1.11e-15	81.6	COG0661@1|root,KOG1235@2759|Eukaryota,37N5M@33090|Viridiplantae,3GF6V@35493|Streptophyta	35493|Streptophyta	S	domain-containing protein	-	-	-	ko:K08869	-	-	-	-	ko00000,ko01001	-	-	-	ABC1,Beta-lactamase,WaaY
k59_443829_1	118166.JH976537_gene4649	3.76e-13	67.8	COG2761@1|root,COG2761@2|Bacteria,1G41Q@1117|Cyanobacteria,1H6XN@1150|Oscillatoriales	1117|Cyanobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_868575_2	479433.Caci_8234	2.44e-33	119.0	COG1695@1|root,COG1695@2|Bacteria,2IQSE@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator PadR family protein	ywzG	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_575653_2	326427.Cagg_1491	8.44e-12	65.1	COG3628@1|root,COG3628@2|Bacteria,2G71T@200795|Chloroflexi,377R5@32061|Chloroflexia	32061|Chloroflexia	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
k59_767701_1	204773.HEAR0357	7.93e-161	467.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,473CK@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	fdwB	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_20632_1	1122194.AUHU01000008_gene3310	3.74e-96	288.0	COG3022@1|root,COG3022@2|Bacteria,1MUAF@1224|Proteobacteria,1RMTD@1236|Gammaproteobacteria,4644D@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0246 family	yaaA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700	-	ko:K09861	-	-	-	-	ko00000	-	-	-	H2O2_YaaD
k59_408618_1	861299.J421_1872	1.56e-104	317.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
k59_245342_1	580332.Slit_0982	8.1e-86	271.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,44VCR@713636|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter transmembrane region	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_837205_2	566466.NOR53_2188	3.77e-50	161.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1JA8C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
k59_837205_3	1348657.M622_04340	4.4e-42	147.0	COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,2KW96@206389|Rhodocyclales	206389|Rhodocyclales	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
k59_837205_4	265072.Mfla_0357	2.41e-89	271.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,2KM94@206350|Nitrosomonadales	206350|Nitrosomonadales	S	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_21651_1	1349767.GJA_4705	1.44e-46	160.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,472AK@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_576716_2	1191523.MROS_2539	3.88e-41	135.0	2C8VT@1|root,32RN1@2|Bacteria	2|Bacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DUF2795
k59_87108_1	1038858.AXBA01000011_gene1454	1.77e-119	359.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_409490_1	977880.RALTA_A2668	2.4e-29	119.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJJD@28216|Betaproteobacteria,1K1EB@119060|Burkholderiaceae	28216|Betaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_511444_1	420662.Mpe_A3765	7.1e-22	90.5	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria,1KIYP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
k59_511444_2	1538295.JY96_07655	1.59e-36	127.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2VU20@28216|Betaproteobacteria,1KMAT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_576717_1	1185652.USDA257_c22550	1.2e-51	173.0	COG4106@1|root,COG4106@2|Bacteria,1QVHH@1224|Proteobacteria,2TXG5@28211|Alphaproteobacteria,4BNYB@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_584994_3	1396418.BATQ01000038_gene5752	5.98e-88	280.0	28HPK@1|root,2Z7XJ@2|Bacteria,46VI6@74201|Verrucomicrobia,2IVHI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Bacteriophage head to tail connecting protein	-	-	-	-	-	-	-	-	-	-	-	-	Head-tail_con
k59_519527_1	1218075.BAYA01000048_gene6751	1.71e-52	184.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VK3I@28216|Betaproteobacteria,1K35H@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_846505_2	545276.KB898731_gene2285	1.06e-50	165.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,1WYJN@135613|Chromatiales	135613|Chromatiales	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_683112_1	666681.M301_0482	6.18e-18	82.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria,2KMXE@206350|Nitrosomonadales	206350|Nitrosomonadales	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_908785_1	1217718.ALOU01000037_gene2038	4.01e-12	66.2	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_908785_2	1123368.AUIS01000005_gene485	1.46e-42	153.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,2NBSD@225057|Acidithiobacillales	225057|Acidithiobacillales	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_61120_1	987059.RBXJA2T_00679	8.91e-88	275.0	COG2866@1|root,COG2866@2|Bacteria,1R586@1224|Proteobacteria	1224|Proteobacteria	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_481285_1	472759.Nhal_0237	6.95e-74	234.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria,1X1NE@135613|Chromatiales	135613|Chromatiales	L	transposase IS4	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_1007490_1	933262.AXAM01000001_gene354	2.67e-79	243.0	COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,42NM0@68525|delta/epsilon subdivisions,2WM96@28221|Deltaproteobacteria,2MHSQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_1007494_1	156889.Mmc1_2456	9.25e-05	50.1	COG0784@1|root,COG2198@1|root,COG3300@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG3300@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
k59_944036_2	1341181.FLJC2902T_13220	1.64e-59	189.0	2DCHV@1|root,2ZE7Q@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_386814_1	330214.NIDE3936	2.97e-97	290.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,fn3_3
k59_127156_1	1408428.JNJP01000005_gene81	2.9e-47	172.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2M8WP@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512	Aldedh,Pro_dh
k59_416428_1	948106.AWZT01000011_gene2074	3.6e-62	196.0	COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2WEAK@28216|Betaproteobacteria,1K11E@119060|Burkholderiaceae	28216|Betaproteobacteria	K	response regulator	qseB	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_416428_2	261292.Nit79A3_1078	4.61e-30	119.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VHNB@28216|Betaproteobacteria,371VU@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_61139_1	436308.Nmar_1725	1.37e-139	402.0	COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI
k59_95252_1	316274.Haur_3477	6.14e-16	85.5	COG2909@1|root,COG2909@2|Bacteria,2G7Q4@200795|Chloroflexi,3754G@32061|Chloroflexia	32061|Chloroflexia	K	ATP-dependent transcriptional regulator, MalT-like, LuxR family	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_386826_1	1005048.CFU_4203	8.92e-18	84.7	2DP0A@1|root,3300Q@2|Bacteria,1N78Y@1224|Proteobacteria,2VVZ5@28216|Betaproteobacteria,474AI@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PFAM Sporulation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_877321_1	1366050.N234_05245	1.85e-96	288.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,1K2UE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_29539_1	1095769.CAHF01000010_gene1221	1.71e-86	271.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,475GZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	AMP-binding enzyme C-terminal domain	bclA_2	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_519571_1	696747.NIES39_A00810	2.92e-54	180.0	COG2234@1|root,COG2234@2|Bacteria,1G1QW@1117|Cyanobacteria,1H7N7@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_715864_1	882082.SaccyDRAFT_2635	5.78e-47	166.0	COG5434@1|root,COG5434@2|Bacteria,2HEP8@201174|Actinobacteria,4EABR@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolases family 28	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
k59_191899_1	1101192.KB910516_gene294	6.19e-19	92.4	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1JRHV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PPC
k59_908821_1	384765.SIAM614_14350	2.1e-83	256.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0714 MoxR-like ATPases	coxD	-	-	-	-	-	-	-	-	-	-	-	AAA_5
k59_715867_1	373903.Hore_09670	5.01e-45	166.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
k59_519575_1	570967.JMLV01000003_gene2298	3.54e-28	112.0	COG2223@1|root,COG2223@2|Bacteria,1QU99@1224|Proteobacteria,2TW9H@28211|Alphaproteobacteria,2JYYS@204441|Rhodospirillales	204441|Rhodospirillales	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_519575_2	977880.RALTA_A2831	1.03e-31	117.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,1K08A@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186,ko:K16875	ko00130,ko00365,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R10213,R11225	RC00391,RC00814,RC03086,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_976879_1	330214.NIDE0855	1.95e-110	321.0	COG1392@1|root,COG1392@2|Bacteria	2|Bacteria	P	Protein of unknown function DUF47	MA20_27875	-	-	ko:K02039,ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_191905_1	404589.Anae109_1032	7.6e-39	149.0	COG4262@1|root,COG4262@2|Bacteria	2|Bacteria	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,Spermine_synth
k59_715875_1	864069.MicloDRAFT_00005320	5.82e-62	209.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_416454_1	330214.NIDE4369	1.53e-44	146.0	COG3357@1|root,COG3357@2|Bacteria	2|Bacteria	K	Transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	HTH_5,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_877343_1	1278073.MYSTI_03434	9.35e-79	263.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,CarbopepD_reg_2,Plug
k59_1007553_1	1370121.AUWS01000124_gene2732	4.52e-59	185.0	COG2452@1|root,COG2452@2|Bacteria,2IDNQ@201174|Actinobacteria,235UX@1762|Mycobacteriaceae	201174|Actinobacteria	L	Resolvase, N terminal domain	-	-	-	ko:K07450	-	-	-	-	ko00000	-	-	-	Resolvase
k59_1007553_2	1120950.KB892812_gene7040	1.04e-26	105.0	COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
k59_416467_1	1189619.pgond44_14073	1.92e-33	133.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,TPR_12,TPR_7
k59_95293_1	999541.bgla_1g04730	2.32e-89	269.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2VIN7@28216|Betaproteobacteria,1K1AS@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_61178_1	1218084.BBJK01000007_gene1045	8.59e-37	140.0	COG2010@1|root,COG2010@2|Bacteria,1R4K1@1224|Proteobacteria,2VPYX@28216|Betaproteobacteria,1K3KC@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_715901_1	313598.MED152_03765	2.29e-05	50.1	2CG1Y@1|root,31NHZ@2|Bacteria,4NQ9Z@976|Bacteroidetes,1I375@117743|Flavobacteriia,3VWMD@52959|Polaribacter	976|Bacteroidetes	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
k59_748407_1	460265.Mnod_2174	1.69e-22	96.7	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,1JRC8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM Phosphate acetyl butaryl transferase	dme	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_386867_1	1117647.M5M_00630	1.21e-32	129.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1J4HM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125	GATase_6,Pribosyltran
k59_944105_1	926569.ANT_22780	8.26e-36	127.0	COG1047@1|root,COG1047@2|Bacteria,2G744@200795|Chloroflexi	200795|Chloroflexi	G	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_253179_1	1380391.JIAS01000013_gene3738	3.09e-12	72.4	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,2JTNS@204441|Rhodospirillales	204441|Rhodospirillales	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_538671_1	1198452.Jab_2c29140	5.7e-35	123.0	COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,2VSPC@28216|Betaproteobacteria,474Q9@75682|Oxalobacteraceae	28216|Betaproteobacteria	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
k59_538671_2	264198.Reut_A0816	1.12e-39	148.0	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_416474_1	1123393.KB891327_gene347	2.34e-89	277.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,1KSEY@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS
k59_717013_1	1304885.AUEY01000005_gene879	1.54e-55	197.0	COG2202@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
k59_387878_1	543728.Vapar_1979	5.66e-173	505.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,4AD7Y@80864|Comamonadaceae	28216|Betaproteobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_482327_1	1122165.AUHS01000005_gene1717	2.08e-26	108.0	COG1680@1|root,COG1680@2|Bacteria,1PHIG@1224|Proteobacteria,1SWR9@1236|Gammaproteobacteria,1JGDJ@118969|Legionellales	118969|Legionellales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_776773_1	1229909.NSED_09745	3.55e-83	259.0	COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_30678_1	926550.CLDAP_36610	8.15e-88	265.0	COG3293@1|root,COG3293@2|Bacteria,2G7YC@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_482331_1	371731.Rsw2DRAFT_3297	4.73e-167	477.0	COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_617834_1	1028800.RG540_PA12590	4.95e-57	187.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	NMT1,NMT1_2
k59_978080_1	246197.MXAN_3684	8.89e-105	318.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,42P6Z@68525|delta/epsilon subdivisions,2WK5W@28221|Deltaproteobacteria,2YUMK@29|Myxococcales	28221|Deltaproteobacteria	G	Maltogenic Amylase, C-terminal domain	treS	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_128391_1	96561.Dole_0551	3.47e-92	283.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2MISS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_650126_1	305700.B447_20760	2.77e-18	83.6	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VHQI@28216|Betaproteobacteria,2KUHQ@206389|Rhodocyclales	206389|Rhodocyclales	E	aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_650126_2	323848.Nmul_A0130	8.67e-34	129.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VKV7@28216|Betaproteobacteria,3723Y@32003|Nitrosomonadales	28216|Betaproteobacteria	C	TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	ubiH	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_909940_1	323261.Noc_2109	3.83e-86	279.0	COG0508@1|root,COG1249@1|root,COG0508@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding,Pyr_redox_2,Pyr_redox_dim
k59_482342_1	1121918.ARWE01000001_gene3185	4.8e-101	320.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TUU@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_945308_1	1005048.CFU_3932	1.45e-57	189.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,4735M@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Peptidase family M23	-	-	3.4.24.75	ko:K08259	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_128408_1	158189.SpiBuddy_2886	4.15e-66	220.0	COG0441@1|root,COG0441@2|Bacteria,2J5ID@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
k59_945316_1	1232410.KI421415_gene3076	2.16e-44	152.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_387921_1	987059.RBXJA2T_08053	2.96e-34	127.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,1KK1G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_586270_1	177437.HRM2_39300	6.67e-56	195.0	COG1032@1|root,COG1032@2|Bacteria,1NAY8@1224|Proteobacteria,42TR8@68525|delta/epsilon subdivisions,2WQC1@28221|Deltaproteobacteria,2MMMU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_356675_1	713586.KB900536_gene2041	1.12e-77	251.0	COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXQ0@135613|Chromatiales	135613|Chromatiales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_847795_1	1123322.KB904699_gene4608	9.13e-20	89.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_482364_1	396588.Tgr7_1356	1.83e-21	92.8	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1WWM5@135613|Chromatiales	135613|Chromatiales	OU	PFAM peptidase S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_482364_2	519989.ECTPHS_10391	6.91e-45	151.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1WX51@135613|Chromatiales	135613|Chromatiales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_794602_1	935948.KE386494_gene968	3.14e-50	173.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,42EKX@68295|Thermoanaerobacterales	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
k59_520826_2	400668.Mmwyl1_3777	1.26e-49	163.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1XJZG@135619|Oceanospirillales	135619|Oceanospirillales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_356682_1	436308.Nmar_0172	1.05e-73	225.0	COG2151@1|root,arCOG03838@1|root,arCOG01845@2157|Archaea,arCOG03838@2157|Archaea,41SHR@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P,PqqD
k59_329768_2	323848.Nmul_A0388	1.1e-58	197.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,372XV@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_166641_1	640081.Dsui_1973	3.68e-80	262.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KV42@206389|Rhodocyclales	206389|Rhodocyclales	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_689169_1	1121405.dsmv_0616	2.96e-87	279.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,42NNE@68525|delta/epsilon subdivisions,2WJZX@28221|Deltaproteobacteria,2MI6X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	qmoB	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_9,FlpD,Pyr_redox_2
k59_493303_2	1040983.AXAE01000049_gene6180	3.07e-30	118.0	COG1216@1|root,COG2246@1|root,COG1216@2|Bacteria,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	MA20_09515	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
k59_950116_1	1232410.KI421414_gene2842	2.87e-26	105.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,43T3I@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_950116_2	395494.Galf_2641	1.08e-26	105.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,44V9R@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_231543_1	555779.Dthio_PD0504	6.53e-41	152.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,431TI@68525|delta/epsilon subdivisions,2WWAP@28221|Deltaproteobacteria,2MB98@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338
k59_68829_1	1227360.C176_19164	1.65e-16	82.4	COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,4HU0X@91061|Bacilli	91061|Bacilli	ET	Belongs to the bacterial solute-binding protein 3 family	artP	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_884487_1	331869.BAL199_27980	3e-65	209.0	COG0346@1|root,COG0346@2|Bacteria,1MX75@1224|Proteobacteria,2TRQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_721683_2	570967.JMLV01000002_gene1949	2.06e-54	182.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JP9N@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_525765_1	1158292.JPOE01000005_gene468	2.14e-14	74.3	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VIST@28216|Betaproteobacteria,1KJK6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR family	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_199305_1	511051.CSE_10260	5.92e-56	192.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_558566_1	316057.RPD_4170	2.08e-65	207.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,3JSNW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_394772_1	864069.MicloDRAFT_00065990	1.57e-54	182.0	COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,2U230@28211|Alphaproteobacteria,1JXFU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	ko:K13816	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001	-	-	-	ECH_1
k59_199306_1	1162668.LFE_0845	2.28e-46	164.0	COG1625@1|root,COG1625@2|Bacteria,3J0XK@40117|Nitrospirae	40117|Nitrospirae	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
k59_884501_1	1100720.ALKN01000040_gene2251	1.53e-96	289.0	COG2267@1|root,COG2267@2|Bacteria,1MV7P@1224|Proteobacteria,2VPTY@28216|Betaproteobacteria,4AGS7@80864|Comamonadaceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_950143_1	436308.Nmar_1586	1.03e-40	143.0	COG0136@1|root,arCOG00494@2157|Archaea,41SFD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	aspartate-semialdehyde dehydrogenase	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_950143_2	436308.Nmar_1587	1.11e-72	219.0	COG1522@1|root,arCOG01580@2157|Archaea,41SKI@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
k59_917728_1	643562.Daes_2653	3.55e-83	250.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,43A6B@68525|delta/epsilon subdivisions,2X294@28221|Deltaproteobacteria,2MBDE@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
k59_917728_2	1532557.JL37_23680	7.36e-13	65.5	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,3T1CP@506|Alcaligenaceae	28216|Betaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_101364_1	1100721.ALKO01000016_gene1475	7.28e-119	355.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2VJYX@28216|Betaproteobacteria,4AC85@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_329797_1	1487923.DP73_11190	3.68e-22	100.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,260UH@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K10681	ko02020,map02020	M00468	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_like
k59_623732_1	443143.GM18_2495	1.95e-111	334.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,43TBZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_525790_1	933262.AXAM01000019_gene1086	3.53e-61	197.0	COG2221@1|root,COG2221@2|Bacteria,1R5F8@1224|Proteobacteria,42PB3@68525|delta/epsilon subdivisions,2WKJR@28221|Deltaproteobacteria,2MHQY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Proto-chlorophyllide reductase 57 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,Fer4_7,NIR_SIR,PCP_red
k59_199319_1	395964.KE386496_gene2969	3.67e-264	734.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,3NASQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	F	formate-tetrahydrofolate ligase activity	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_36110_1	589865.DaAHT2_2390	3.87e-63	212.0	COG5433@1|root,COG5433@2|Bacteria,1MXI8@1224|Proteobacteria,42WFU@68525|delta/epsilon subdivisions,2WS4T@28221|Deltaproteobacteria,2MKX1@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Pfam Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_460052_1	1192034.CAP_9007	4.27e-76	243.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NSM@68525|delta/epsilon subdivisions,2WJXQ@28221|Deltaproteobacteria,2YUS3@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter, ATP-binding protein	pilH	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_166691_1	1313421.JHBV01000042_gene3327	3.85e-63	206.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_36112_1	945713.IALB_0835	1.71e-92	289.0	COG0342@1|root,COG0342@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_884525_1	6500.XP_005111052.1	3.31e-56	191.0	COG0646@1|root,KOG1579@2759|Eukaryota,38H9Z@33154|Opisthokonta,3BF53@33208|Metazoa	33208|Metazoa	E	betaine-homocysteine S-methyltransferase activity	-	-	2.1.1.5	ko:K00544	ko00260,ko00270,ko01100,map00260,map00270,map01100	-	R02821	RC00035,RC00496	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
k59_918675_1	517417.Cpar_0010	2.75e-86	268.0	COG0446@1|root,COG0446@2|Bacteria,1FDM3@1090|Chlorobi	1090|Chlorobi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
k59_852937_2	330214.NIDE4289	4.64e-51	169.0	COG2732@1|root,COG2732@2|Bacteria	2|Bacteria	K	(Barnase) inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	Barstar
k59_852937_3	330214.NIDE4288	2.3e-11	60.8	COG4290@1|root,COG4290@2|Bacteria	2|Bacteria	F	endoribonuclease activity	-	GO:0005575,GO:0005576	-	ko:K03628,ko:K15125	ko03018,ko05133,map03018,map05133	-	-	-	ko00000,ko00001,ko00536,ko03019,ko03021	-	-	-	Ribonuclease
k59_37031_1	1230476.C207_01300	1.68e-40	147.0	COG0742@1|root,COG0742@2|Bacteria,1MW6A@1224|Proteobacteria,2TQNI@28211|Alphaproteobacteria,3JR22@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	ribosomal rna small subunit methyltransferase	MA20_07810	-	-	-	-	-	-	-	-	-	-	-	-
k59_428527_1	945713.IALB_2801	1.04e-122	360.0	COG0148@1|root,COG0148@2|Bacteria	2|Bacteria	G	phosphopyruvate hydratase activity	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_395511_1	1097668.BYI23_B007710	1.78e-97	294.0	COG3938@1|root,COG3938@2|Bacteria,1NVF9@1224|Proteobacteria,2VHHY@28216|Betaproteobacteria,1K4R9@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the proline racemase family	-	GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855,GO:0036361,GO:0047580,GO:0047661	5.1.1.8	ko:K12658	ko00330,map00330	-	R03296	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
k59_135079_1	1132509.C447_09157	0.000214	48.1	COG0111@1|root,arCOG01757@2157|Archaea,2XU4Y@28890|Euryarchaeota,23SDM@183963|Halobacteria	183963|Halobacteria	H	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	ddh	-	1.1.1.272	ko:K17064	-	-	R10528	RC00501	ko00000,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_135079_2	247634.GPB2148_879	4.78e-11	62.4	2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria	247634.GPB2148_879|-	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_918685_1	388413.ALPR1_12880	6.17e-34	128.0	COG1028@1|root,COG1028@2|Bacteria,4NEUB@976|Bacteroidetes,47MT3@768503|Cytophagia	976|Bacteroidetes	IQ	KR domain	-	-	1.3.1.25	ko:K05783	ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00622,map01100,map01120,map01220	M00551	R00813,R05292,R05293,R05309,R05314,R08111,R08112,R08113	RC00271,RC01326,RC01327	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
k59_690147_1	330214.NIDE0952	1.79e-70	221.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	3.6.1.11,3.6.1.40	ko:K01524,ko:K07012	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000,ko02048	-	-	-	HD
k59_885401_1	945713.IALB_0638	1.64e-94	287.0	COG0195@1|root,COG0195@2|Bacteria	2|Bacteria	K	DNA-templated transcription, termination	nusA	GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_428538_1	713586.KB900536_gene1141	3.64e-64	211.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1WXE2@135613|Chromatiales	135613|Chromatiales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_232304_1	871963.Desdi_0975	8.34e-12	67.8	COG3381@1|root,COG3381@2|Bacteria,1VGZ7@1239|Firmicutes,24SRM@186801|Clostridia	186801|Clostridia	S	PFAM cytoplasmic chaperone TorD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
k59_983455_2	864051.BurJ1DRAFT_3327	1.04e-51	178.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,1KKEG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NADPH-dependent glutamate synthase beta	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_21,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_754482_1	96561.Dole_1512	4.79e-50	169.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2MJC5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_852966_1	75379.Tint_2227	4e-42	149.0	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,2VKN0@28216|Betaproteobacteria,1KIZI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Lipid A biosynthesis acyltransferase	htrB_2	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_918712_1	223926.28806353	1.62e-39	147.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1XVZK@135623|Vibrionales	135623|Vibrionales	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_460768_1	667632.KB890168_gene5189	2.39e-128	378.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VHC1@28216|Betaproteobacteria,1K09M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520,ko:K21739	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_460768_2	1230476.C207_06443	1.28e-84	260.0	COG0179@1|root,COG0179@2|Bacteria,1NM05@1224|Proteobacteria,2U0IB@28211|Alphaproteobacteria,3JRKT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_885416_1	1469245.JFBG01000062_gene2271	2.24e-92	295.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_69829_1	159087.Daro_3026	4.42e-41	143.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,2KWGP@206389|Rhodocyclales	206389|Rhodocyclales	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_69829_2	226899.F0XQ18	2.88e-12	63.9	COG3526@1|root,2S6UH@2759|Eukaryota,3A6V6@33154|Opisthokonta,3P55U@4751|Fungi,3QX8M@4890|Ascomycota,21ARN@147550|Sordariomycetes,3UU7P@5151|Ophiostomatales	4751|Fungi	O	Rdx family	-	-	-	ko:K07401	-	-	-	-	ko00000	-	-	-	Rdx
k59_200238_1	1123487.KB892835_gene3710	8.18e-09	63.9	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_460780_1	1229909.NSED_00560	5.03e-13	67.4	COG0109@1|root,arCOG00479@2157|Archaea,41SFH@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_885434_2	1095769.CAHF01000014_gene2868	4.63e-85	263.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,472TI@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_135118_1	305700.B447_20333	1.11e-17	80.5	COG2267@1|root,COG2267@2|Bacteria,1QVSP@1224|Proteobacteria,2WGT8@28216|Betaproteobacteria,2KZP9@206389|Rhodocyclales	206389|Rhodocyclales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_135118_2	1454004.AW11_02662	1.18e-111	337.0	COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria	28216|Betaproteobacteria	S	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
k59_135118_3	556268.OFAG_01428	1.06e-100	297.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,473B4@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Phosphatidylethanolamine-binding protein	bbsI	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_657572_1	272568.GDI2363	2.56e-74	239.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TT6V@28211|Alphaproteobacteria,2JPWF@204441|Rhodospirillales	204441|Rhodospirillales	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_820796_1	96561.Dole_3265	1.35e-39	160.0	COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2X734@28221|Deltaproteobacteria,2MIC0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_37099_1	375286.mma_3356	4.59e-12	65.1	COG4726@1|root,COG4726@2|Bacteria,1N9CE@1224|Proteobacteria,2VWPP@28216|Betaproteobacteria,47556@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_37099_2	1286631.X805_20170	6.33e-18	88.6	COG4966@1|root,COG4966@2|Bacteria,1RH2G@1224|Proteobacteria,2VT5C@28216|Betaproteobacteria,1KMMA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type IV Pilus-assembly protein W	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
k59_690218_1	864051.BurJ1DRAFT_3700	3.77e-39	149.0	COG0726@1|root,COG0823@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3420@1|root,COG0726@2|Bacteria,COG0823@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,1MU7T@1224|Proteobacteria,2WI67@28216|Betaproteobacteria,1KMDS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MQU	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
k59_754516_1	1000565.METUNv1_00041	2.61e-52	185.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,2KUWP@206389|Rhodocyclales	206389|Rhodocyclales	O	peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_3
k59_592097_1	1538295.JY96_17005	1.67e-40	141.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,1KM5G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_820802_1	525263.HMPREF0298_0712	1.18e-41	155.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,22JUA@1653|Corynebacteriaceae	201174|Actinobacteria	JKL	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k59_853001_1	1380355.JNIJ01000004_gene2787	2.29e-93	283.0	COG2358@1|root,COG2358@2|Bacteria,1NRH6@1224|Proteobacteria,2TT34@28211|Alphaproteobacteria,3JTPF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_853001_2	1123487.KB892857_gene2418	2.86e-148	441.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,2KUV3@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_363298_1	342113.DM82_6236	2.98e-16	79.7	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VMBM@28216|Betaproteobacteria,1K1HQ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	alcohol dehydrogenase	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_363298_2	580332.Slit_2559	2.13e-76	231.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2VP8A@28216|Betaproteobacteria,44W9X@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	hyfI	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
k59_460797_1	929556.Solca_4452	3.93e-64	205.0	COG0500@1|root,COG2226@2|Bacteria,4NG68@976|Bacteroidetes,1IRA0@117747|Sphingobacteriia	976|Bacteroidetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_592103_1	686340.Metal_0376	5.53e-31	110.0	COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,1S8XM@1236|Gammaproteobacteria,1XFI5@135618|Methylococcales	135618|Methylococcales	S	PFAM Lipid A Biosynthesis N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
k59_592103_2	1279038.KB907340_gene1536	9.78e-37	131.0	COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,2TTR9@28211|Alphaproteobacteria,2JQI8@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_951153_1	1125973.JNLC01000010_gene1490	2.42e-114	348.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3JVBW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_951153_2	1209072.ALBT01000061_gene1006	1.75e-29	114.0	2DC00@1|root,2ZC4V@2|Bacteria,1RBPR@1224|Proteobacteria,1S2KT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_460799_1	879212.DespoDRAFT_01048	1.84e-74	244.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_787553_1	421072.IO89_07360	2.97e-48	175.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia,3HIM0@358033|Chryseobacterium	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_502355_1	319003.Bra1253DRAFT_01455	2.56e-59	194.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,3JUQJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	MA20_26650	-	-	-	-	-	-	-	-	-	-	-	NMT1
k59_142955_1	1121939.L861_01745	3.17e-80	243.0	COG1765@1|root,COG1765@2|Bacteria,1QUE7@1224|Proteobacteria,1S84Z@1236|Gammaproteobacteria,1XKED@135619|Oceanospirillales	135619|Oceanospirillales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_787557_1	1205680.CAKO01000010_gene3710	1.53e-78	242.0	COG2175@1|root,COG2175@2|Bacteria,1P6UZ@1224|Proteobacteria,2TTJB@28211|Alphaproteobacteria,2JYSV@204441|Rhodospirillales	204441|Rhodospirillales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_632364_1	1562701.BBOF01000029_gene872	5.61e-103	331.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1K1A9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_926757_2	395495.Lcho_2991	7.21e-25	104.0	2EFKN@1|root,339CX@2|Bacteria,1N8ST@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_502373_1	1288494.EBAPG3_25510	4.26e-111	333.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria,372M4@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	Nucleoside H+ symporter	hcaT	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_306159_1	580332.Slit_2932	7.99e-104	307.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,44VME@713636|Nitrosomonadales	28216|Betaproteobacteria	F	PFAM aspartate ornithine carbamoyltransferase Asp Orn-binding region	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_467939_1	999411.HMPREF1092_00591	2.29e-45	159.0	COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,36DBJ@31979|Clostridiaceae	186801|Clostridia	H	molybdopterin binding domain	moeA2	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_371838_1	396588.Tgr7_2043	6.18e-168	481.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1WWTQ@135613|Chromatiales	135613|Chromatiales	E	PFAM aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_239462_1	1415779.JOMH01000001_gene2583	5.66e-63	208.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1X4TP@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the IlvD Edd family	-	-	-	-	-	-	-	-	-	-	-	-	ILVD_EDD
k59_633348_1	290400.Jann_3726	4.08e-06	50.1	2CDFF@1|root,32RXP@2|Bacteria,1N26W@1224|Proteobacteria,2UDNJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_437126_1	420662.Mpe_A0075	1.99e-109	323.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,1KIVV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_960369_1	1353531.AZNX01000012_gene3971	4.71e-14	75.5	COG2207@1|root,COG2207@2|Bacteria,1R81X@1224|Proteobacteria,2U0BK@28211|Alphaproteobacteria,4B6Y7@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	AraC-binding-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
k59_45910_1	713586.KB900536_gene1945	3.94e-46	167.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_371840_1	666681.M301_0602	1.66e-91	279.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,2KKCS@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_761706_1	330214.NIDE3569	2.09e-91	274.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	norQ	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_503413_1	1123504.JQKD01000018_gene2062	6.56e-05	45.4	COG3181@1|root,COG3181@2|Bacteria,1MWSC@1224|Proteobacteria,2VZGI@28216|Betaproteobacteria,4AH6N@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_503413_2	1218084.BBJK01000007_gene906	3.8e-268	741.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2W1P1@28216|Betaproteobacteria,1K0XN@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_339654_1	640081.Dsui_1449	9.87e-158	469.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales	206389|Rhodocyclales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
k59_666665_1	572544.Ilyop_0290	3.51e-20	91.7	COG3181@1|root,COG3181@2|Bacteria,379J4@32066|Fusobacteria	32066|Fusobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_666665_2	1205680.CAKO01000006_gene3271	1.19e-58	185.0	COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,2U5ES@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein possibly involved in utilization of glycolate and propanediol	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_273071_2	172088.AUGA01000030_gene7634	2.49e-54	179.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2TVM0@28211|Alphaproteobacteria,3JW6H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	ligJ	-	4.1.1.45,4.2.1.83	ko:K03392,ko:K10220	ko00362,ko00380,ko01100,ko01120,map00362,map00380,map01100,map01120	M00038	R04323,R04478	RC00498,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_731868_1	1236973.JCM9157_121	1.99e-65	209.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4HAJC@91061|Bacilli,1ZCC8@1386|Bacillus	91061|Bacilli	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
k59_437138_1	397948.Cmaq_1261	4.94e-61	208.0	COG0603@1|root,arCOG00039@2157|Archaea,2XQ5Q@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	GATase_7,QueC
k59_208937_1	1454004.AW11_03689	9.65e-70	223.0	2C8FN@1|root,2ZBER@2|Bacteria,1RK02@1224|Proteobacteria,2WG0U@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_437142_1	1128421.JAGA01000001_gene2383	4.37e-50	173.0	COG0624@1|root,COG0624@2|Bacteria,2NQBR@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	lysK	-	3.5.1.16	ko:K01438,ko:K05831	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R00669,R09107,R09779,R10933	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
k59_568607_1	1049564.TevJSym_bc00390	1.77e-33	131.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	hydB	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_893833_1	1245475.ANAE01000143_gene4929	2.27e-09	63.9	COG2366@1|root,COG2366@2|Bacteria,2GKEN@201174|Actinobacteria,4EMYS@85012|Streptosporangiales	201174|Actinobacteria	S	Penicillin amidase	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Penicil_amidase
k59_273080_1	1123392.AQWL01000010_gene2311	1.05e-53	180.0	COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,2VPGW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2219)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2219
k59_992152_1	266265.Bxe_A0056	6.7e-68	218.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,1K21G@119060|Burkholderiaceae	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_144011_1	1158146.KB907134_gene1478	4.6e-46	157.0	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria,1WW5S@135613|Chromatiales	135613|Chromatiales	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_144011_2	396588.Tgr7_1267	1.7e-127	375.0	COG0247@1|root,COG1145@1|root,COG0247@2|Bacteria,COG1145@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1WWK6@135613|Chromatiales	135613|Chromatiales	C	PFAM Cysteine-rich	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_992156_1	1424334.W822_19640	6.26e-85	259.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2VIKK@28216|Betaproteobacteria,3T6I6@506|Alcaligenaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_731902_1	477974.Daud_1042	2.69e-42	154.0	COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,25ZXY@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_927851_2	1283300.ATXB01000001_gene1032	2.17e-55	186.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1XEQ5@135618|Methylococcales	135618|Methylococcales	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_731903_1	999141.GME_17022	2.44e-164	479.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XHB9@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_239514_1	1123054.KB907702_gene1445	2.15e-28	115.0	COG1506@1|root,COG1506@2|Bacteria,1MWFI@1224|Proteobacteria,1RPJD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
k59_861663_1	1125973.JNLC01000011_gene652	8.85e-62	204.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria,3JYUS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_601056_1	56780.SYN_02630	2.98e-189	543.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,42P6Z@68525|delta/epsilon subdivisions,2WK5W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM alpha amylase, catalytic	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_437178_1	1299327.I546_2981	2.13e-09	59.7	COG0446@1|root,COG0446@2|Bacteria,2I4HJ@201174|Actinobacteria,23F7X@1762|Mycobacteriaceae	201174|Actinobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_437178_2	382464.ABSI01000010_gene3861	8.89e-25	100.0	COG2258@1|root,COG2258@2|Bacteria	2|Bacteria	C	MOSC domain	yuaD	-	-	-	-	-	-	-	-	-	-	-	MOSC
k59_208983_1	1459636.NTE_00019	6.24e-74	237.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_960436_1	1163617.SCD_n02913	6.04e-128	372.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_437186_1	335283.Neut_2128	8.47e-17	83.2	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,3725T@32003|Nitrosomonadales	28216|Betaproteobacteria	NU	type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GAF,T2SSE,T2SSE_N
k59_830040_1	1123368.AUIS01000001_gene1973	5.58e-36	140.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,2NC8G@225057|Acidithiobacillales	225057|Acidithiobacillales	KL	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_731927_1	1121456.ATVA01000014_gene713	3.64e-28	116.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2M9RV@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_176669_1	748280.NH8B_3532	4.27e-108	324.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KQHP@206351|Neisseriales	206351|Neisseriales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_893882_1	1121405.dsmv_0197	1.33e-224	635.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MINQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_239526_1	1198452.Jab_1c17600	7.65e-05	52.8	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_8,Response_reg
k59_339737_1	1125863.JAFN01000001_gene1789	1.91e-49	162.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,42QXP@68525|delta/epsilon subdivisions,2WP9I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_992199_1	443143.GM18_0309	1.72e-32	140.0	COG2770@1|root,COG4191@1|root,COG2770@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg,dCache_1
k59_468025_2	1123393.KB891331_gene2887	5.69e-29	113.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2VH76@28216|Betaproteobacteria,1KRXW@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_306258_1	748247.AZKH_0068	3.24e-05	45.1	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales	206389|Rhodocyclales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_306258_2	1000565.METUNv1_04051	1.21e-137	396.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales	206389|Rhodocyclales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
k59_306258_3	76114.ebA5430	1.27e-17	81.3	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,2KURW@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_209020_1	469381.Dpep_0162	0.0004	48.9	COG4241@1|root,COG4241@2|Bacteria,3TA3B@508458|Synergistetes	508458|Synergistetes	S	membrane protein (DUF2232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
k59_209020_2	1089553.Tph_c00720	1.68e-25	96.7	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,42H4H@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_601097_1	1005048.CFU_2503	4.66e-87	267.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,47351@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_601097_2	1163617.SCD_n00919	1.48e-97	311.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_273120_1	1297570.MESS4_670041	3.73e-77	245.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_468041_1	1122604.JONR01000020_gene464	4.84e-34	130.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1X3AK@135614|Xanthomonadales	135614|Xanthomonadales	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_601108_1	323848.Nmul_A1953	1.94e-106	330.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,371V5@32003|Nitrosomonadales	28216|Betaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_79113_2	1288494.EBAPG3_21640	4.64e-160	454.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,3729E@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_79113_3	1485544.JQKP01000001_gene1033	2.07e-97	289.0	COG0637@1|root,COG0637@2|Bacteria,1QTWD@1224|Proteobacteria,2VNTW@28216|Betaproteobacteria,44UZ1@713636|Nitrosomonadales	28216|Betaproteobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
k59_79113_4	1163617.SCD_n02703	1.44e-90	270.0	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,2VQ4C@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	slmA	-	-	ko:K05501	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	TetR_N
k59_893913_1	330214.NIDE3440	1.36e-48	174.0	COG0457@1|root,COG0457@2|Bacteria,3J0MH@40117|Nitrospirae	40117|Nitrospirae	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
k59_675398_2	436308.Nmar_1588	9.63e-164	462.0	COG0109@1|root,arCOG00479@2157|Archaea,41SFH@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_641681_1	360911.EAT1b_2506	1.37e-21	96.7	COG1609@1|root,COG1609@2|Bacteria,1TPZM@1239|Firmicutes,4H9ZT@91061|Bacilli,3WFEJ@539002|Bacillales incertae sedis	91061|Bacilli	K	helix_turn _helix lactose operon repressor	malR	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_870047_1	861299.J421_5897	2.5e-32	131.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_5897|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_217142_1	365044.Pnap_2179	9.22e-37	135.0	COG3212@1|root,COG3212@2|Bacteria,1N0D3@1224|Proteobacteria	1224|Proteobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
k59_379877_1	552398.HMPREF0866_00425	6.27e-27	109.0	COG1099@1|root,COG1099@2|Bacteria,1UXNI@1239|Firmicutes,24GSG@186801|Clostridia,3WQCR@541000|Ruminococcaceae	186801|Clostridia	S	with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_409940_1	1211115.ALIQ01000212_gene3268	3.45e-86	260.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,3NA3P@45404|Beijerinckiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
k59_445278_1	945713.IALB_0796	2.43e-22	94.0	COG0253@1|root,COG0253@2|Bacteria	2|Bacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0566,iLJ478.TM1522	DAP_epimerase
k59_277266_1	1121930.AQXG01000001_gene1524	1.89e-39	149.0	2E09V@1|root,32VXB@2|Bacteria,4NY12@976|Bacteroidetes,1J03H@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_936469_1	1532557.JL37_07905	1.34e-33	128.0	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,3T2GI@506|Alcaligenaceae	28216|Betaproteobacteria	C	COG3245 Cytochrome c5	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_54013_1	1144664.F973_00657	1.11e-15	72.8	COG3415@1|root,COG3415@2|Bacteria,1N3D0@1224|Proteobacteria,1SE8Y@1236|Gammaproteobacteria,3NNQ7@468|Moraxellaceae	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_IS630
k59_54013_2	406818.XBJ1_2582	5.78e-18	78.2	COG3335@1|root,COG3335@2|Bacteria,1RJPC@1224|Proteobacteria,1SZ4U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_Tnp_IS630
k59_769026_1	502025.Hoch_2696	2.94e-123	372.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,43850@68525|delta/epsilon subdivisions,2WX9Z@28221|Deltaproteobacteria,2YWVT@29|Myxococcales	28221|Deltaproteobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_675427_1	1122135.KB893135_gene996	1.18e-97	298.0	COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,2TTAU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	catalyzes the formation of indole and pyruvate from tryptophan	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_901712_1	1297742.A176_05122	6.66e-23	97.1	COG0073@1|root,COG0073@2|Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890,ko:K06878	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,RNA_ligase,tRNA_bind
k59_1000423_1	330214.NIDE0691	4.46e-31	114.0	COG2094@1|root,COG2094@2|Bacteria	2|Bacteria	L	Belongs to the DNA glycosylase MPG family	mpg	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
k59_936477_1	946483.Cenrod_0957	3.93e-106	324.0	COG3039@1|root,COG3039@2|Bacteria,1R64B@1224|Proteobacteria,2W09R@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_87633_1	545694.TREPR_1654	4.1e-10	63.5	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
k59_313844_1	1245469.S58_30920	3.08e-35	143.0	COG4105@1|root,COG4571@1|root,COG4105@2|Bacteria,COG4571@2|Bacteria,1QYYT@1224|Proteobacteria,2TY1X@28211|Alphaproteobacteria,3K6VK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Outer membrane protease	-	-	-	-	-	-	-	-	-	-	-	-	Pom
k59_379904_1	1397696.KK211189_gene1228	6.54e-12	65.1	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H9R3@91061|Bacilli,3WEI9@539002|Bacillales incertae sedis	91061|Bacilli	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSB619.SA_RS04145	PGK
k59_379904_2	1121013.P873_11290	3.13e-32	122.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1X34S@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_577244_1	1124780.ANNU01000013_gene3853	0.000998	43.1	COG3198@1|root,COG3198@2|Bacteria,4PPZ3@976|Bacteroidetes,47RV1@768503|Cytophagia	976|Bacteroidetes	S	FixH	ccoH	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
k59_577244_2	945713.IALB_0724	1.1e-37	139.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ccoG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_511955_1	93220.LV28_21370	3.36e-42	150.0	COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2VN8N@28216|Betaproteobacteria,1K3YZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Haloacid dehalogenase, type II	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_740657_1	323848.Nmul_A1015	1.07e-194	556.0	COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,3743I@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
k59_641721_1	585502.HMPREF0645_0753	2.17e-17	90.5	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_838794_1	645512.GCWU000246_01800	4.97e-27	114.0	COG4666@1|root,COG4666@2|Bacteria,3TAHY@508458|Synergistetes	508458|Synergistetes	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_87645_1	767434.Fraau_1596	3.52e-69	218.0	COG3293@1|root,COG3293@2|Bacteria,1N13W@1224|Proteobacteria,1SB65@1236|Gammaproteobacteria,1XCUQ@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_675458_1	118166.JH976537_gene21	1.14e-08	62.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_445318_2	349521.HCH_00106	6.82e-76	230.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Coenzyme F420-reducing hydrogenase, gamma subunit	hoxY	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
k59_969165_1	1403819.BATR01000195_gene6595	8.69e-83	265.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_22189_1	1123228.AUIH01000011_gene2028	3.85e-51	179.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XIWG@135619|Oceanospirillales	135619|Oceanospirillales	V	ABC transporter transmembrane region	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_609435_2	580332.Slit_1690	2.66e-67	208.0	COG0425@1|root,COG0425@2|Bacteria,1PX23@1224|Proteobacteria,2WCJT@28216|Betaproteobacteria,44W8S@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
k59_609435_3	292415.Tbd_2488	1.12e-51	165.0	COG2920@1|root,COG2920@2|Bacteria,1N2HP@1224|Proteobacteria,2VVGF@28216|Betaproteobacteria	28216|Betaproteobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_119892_2	984262.SGRA_2470	7.99e-05	48.5	COG1595@1|root,COG1595@2|Bacteria,4NMC0@976|Bacteroidetes,1IQKN@117747|Sphingobacteriia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_410001_1	215803.DB30_7218	2.76e-23	102.0	COG0412@1|root,COG0412@2|Bacteria,1QRBY@1224|Proteobacteria,43E13@68525|delta/epsilon subdivisions,2WZE4@28221|Deltaproteobacteria,2Z1XS@29|Myxococcales	28221|Deltaproteobacteria	Q	Chlorophyllase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_641753_1	1121004.ATVC01000053_gene763	1.85e-05	46.2	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,2KPXZ@206351|Neisseriales	206351|Neisseriales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_641753_2	983917.RGE_46940	2.33e-22	91.7	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,2VRC4@28216|Betaproteobacteria,1KKP8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_838825_1	595537.Varpa_3236	4.79e-11	68.9	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,2VHP0@28216|Betaproteobacteria,4ACSF@80864|Comamonadaceae	28216|Betaproteobacteria	S	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
k59_838825_2	1122604.JONR01000006_gene2600	8.4e-32	120.0	COG0463@1|root,COG0463@2|Bacteria,1QTWH@1224|Proteobacteria,1T2BN@1236|Gammaproteobacteria,1XDEW@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_936523_1	497321.C664_19883	1.97e-55	184.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VN1Z@28216|Betaproteobacteria,2KXKA@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Lactamase_B
k59_936523_2	1000565.METUNv1_01519	2.06e-27	107.0	COG5501@1|root,COG5501@2|Bacteria,1RBHP@1224|Proteobacteria,2VR7Y@28216|Betaproteobacteria,2KXWK@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulphur oxidation protein SoxZ	-	-	-	-	-	-	-	-	-	-	-	-	SoxY,SoxZ
k59_675490_1	987059.RBXJA2T_05143	2.86e-98	313.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2VITK@28216|Betaproteobacteria,1KJ8X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.3.8.7,1.5.5.2	ko:K00249,ko:K00294,ko:K13821	ko00071,ko00250,ko00280,ko00330,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00250,map00280,map00330,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00245,R00707,R00708,R00924,R01175,R01253,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04444,R04445,R04751,R04754,R05051	RC00052,RC00068,RC00076,RC00080,RC00083,RC00095,RC00148,RC00216,RC00242,RC00246,RC00255	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_791319_1	580332.Slit_2309	6.37e-77	238.0	COG4783@1|root,COG4783@2|Bacteria,1R84W@1224|Proteobacteria,2VIBK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_22205_1	292415.Tbd_0793	2.87e-122	375.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,1KRHS@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_184750_1	472759.Nhal_0691	2.42e-151	437.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SufE
k59_740707_1	316274.Haur_2039	6.79e-07	57.0	COG3385@1|root,COG3385@2|Bacteria,2G8GC@200795|Chloroflexi,3768R@32061|Chloroflexia	32061|Chloroflexia	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_577304_1	1286631.X805_14420	1.9e-38	137.0	COG1555@1|root,COG1555@2|Bacteria,1N2AZ@1224|Proteobacteria,2W4W8@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
k59_534849_1	240015.ACP_1770	1.63e-50	172.0	COG0133@1|root,COG0133@2|Bacteria,3Y45B@57723|Acidobacteria,2JIVM@204432|Acidobacteriia	204432|Acidobacteriia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_534849_2	1210884.HG799468_gene13783	2.26e-11	63.9	COG0135@1|root,COG0135@2|Bacteria,2IZP6@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_641770_2	94624.Bpet4003	1.13e-53	178.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria,3T1VC@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_708282_1	1159870.KB907784_gene72	2.74e-11	63.5	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,3T327@506|Alcaligenaceae	28216|Betaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_708282_2	497321.C664_06933	3.11e-98	303.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,2KVPJ@206389|Rhodocyclales	206389|Rhodocyclales	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_348075_1	292415.Tbd_0549	5.54e-54	189.0	COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMT1@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type II and III secretion system protein	exeD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N_2
k59_936537_1	266265.Bxe_C0033	1.04e-132	385.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VIJR@28216|Betaproteobacteria,1K34U@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
k59_54093_2	1380394.JADL01000003_gene4840	1.52e-12	66.6	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,2UH20@28211|Alphaproteobacteria,2JTY1@204441|Rhodospirillales	204441|Rhodospirillales	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
k59_54093_3	1121035.AUCH01000004_gene401	8.23e-16	77.4	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,2VN3Y@28216|Betaproteobacteria,2KYF7@206389|Rhodocyclales	206389|Rhodocyclales	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_313914_1	1131266.ARWQ01000009_gene955	4.97e-114	340.0	COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_901799_1	640081.Dsui_2806	2.07e-30	125.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJGE@28216|Betaproteobacteria,2KV5M@206389|Rhodocyclales	206389|Rhodocyclales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_87712_1	76114.ebA4672	6.48e-58	188.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2VKQH@28216|Betaproteobacteria,2KW5S@206389|Rhodocyclales	206389|Rhodocyclales	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_246747_1	523791.Kkor_2074	5.06e-23	102.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase m28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_675524_1	1121948.AUAC01000002_gene1662	2.84e-24	103.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,43XS7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF541)	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
k59_152585_1	1449350.OCH239_02660	4.22e-05	45.8	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,4KKEW@93682|Roseivivax	28211|Alphaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	ldc	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_152585_2	1380391.JIAS01000019_gene1133	3.08e-46	159.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JQTG@204441|Rhodospirillales	204441|Rhodospirillales	E	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
k59_1000517_1	1265505.ATUG01000003_gene516	6.07e-84	259.0	COG0589@1|root,COG0589@2|Bacteria,1RJMY@1224|Proteobacteria,439UF@68525|delta/epsilon subdivisions,2X583@28221|Deltaproteobacteria,2MMT1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_578301_2	864051.BurJ1DRAFT_2067	7.23e-66	212.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,1KMB7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_475851_1	1238182.C882_2010	3.77e-31	124.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,2JQNG@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_247538_1	1183438.GKIL_0328	3.83e-90	285.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1G1ZS@1117|Cyanobacteria	1117|Cyanobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
k59_446277_1	1125973.JNLC01000011_gene607	1.24e-79	244.0	COG1809@1|root,COG1809@2|Bacteria,1NEVX@1224|Proteobacteria,2VG8Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	(2R)-phospho-3-sulfolactate synthase (ComA)	-	-	-	-	-	-	-	-	-	-	-	-	ComA
k59_741695_1	380394.Lferr_0215	7.93e-127	381.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1SWPK@1236|Gammaproteobacteria,2NDCF@225057|Acidithiobacillales	225057|Acidithiobacillales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_676509_1	1282876.BAOK01000002_gene252	6.79e-41	139.0	COG1917@1|root,COG1917@2|Bacteria,1N0BS@1224|Proteobacteria	1224|Proteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
k59_88699_1	265072.Mfla_0077	1.2e-48	171.0	COG0457@1|root,COG0457@2|Bacteria,1RKBG@1224|Proteobacteria,2VQFW@28216|Betaproteobacteria,2KMV8@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_88699_2	1101195.Meth11DRAFT_0142	9.48e-17	79.7	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KKZR@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	General secretory system II protein E domain protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_130093_1	1172190.M947_09370	1.61e-15	80.1	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2YMJQ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.92	ko:K15895	ko00520,map00520	-	R09825	RC00006,RC00781	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
k59_1010204_2	1116472.MGMO_17c00090	2.26e-57	191.0	COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,1S59S@1236|Gammaproteobacteria,1XFTG@135618|Methylococcales	135618|Methylococcales	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
k59_1010204_3	381666.H16_A1821	6.72e-30	114.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKD3@28216|Betaproteobacteria,1K0J2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF2063,DUF692
k59_358493_1	1049564.TevJSym_ax00210	8.94e-73	223.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1JBWT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	ACT domain	gcvR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT,ACT_6
k59_323181_1	215803.DB30_3342	1.14e-08	64.7	COG0170@1|root,COG1836@1|root,COG0170@2|Bacteria,COG1836@2|Bacteria	2|Bacteria	I	PFAM Integral membrane protein DUF92	-	GO:0005575,GO:0016020	2.7.1.182	ko:K18678	-	-	R10659	RC00002,RC00017	ko00000,ko01000	-	-	-	DUF92
k59_651745_1	298655.KI912266_gene4030	1.17e-68	221.0	COG0446@1|root,COG0446@2|Bacteria,2I4F6@201174|Actinobacteria	201174|Actinobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_619481_2	439235.Dalk_2250	1.66e-47	157.0	COG0745@1|root,COG0745@2|Bacteria,1QW16@1224|Proteobacteria,43BR7@68525|delta/epsilon subdivisions,2X723@28221|Deltaproteobacteria,2MPIZ@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_619481_3	644282.Deba_0059	1.47e-07	50.8	COG2204@1|root,COG2204@2|Bacteria,1RJP7@1224|Proteobacteria,42SDG@68525|delta/epsilon subdivisions,2WP9A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_194725_1	1123401.JHYQ01000009_gene2221	2.67e-93	291.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,1RQCS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
k59_194726_1	1121033.AUCF01000014_gene1310	1.08e-53	179.0	COG3181@1|root,COG3181@2|Bacteria,1NBGQ@1224|Proteobacteria,2U3YX@28211|Alphaproteobacteria,2JYNG@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_619487_2	768671.ThimaDRAFT_4485	2.24e-11	64.3	COG0265@1|root,COG1075@1|root,COG2304@1|root,COG0265@2|Bacteria,COG1075@2|Bacteria,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	MA20_07505	-	1.1.3.6,1.6.5.3,3.4.21.107	ko:K00337,ko:K03333,ko:K04771,ko:K07114	ko00190,ko00984,ko01100,ko01120,ko01503,ko02020,map00190,map00984,map01100,map01120,map01503,map02020	M00144,M00728	R01459,R11945	RC00061,RC00146	ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03110	1.A.13.2.2,1.A.13.2.3,3.D.1	-	-	DUF1194
k59_323200_1	330214.NIDE2645	3.87e-35	123.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078,ko:K05553	ko00253,ko01056,ko01130,map00253,map01056,map01130	M00778	R06635,R06637,R06641,R06643,R06644,R06645,R09258,R09259,R10960,R11516	RC00004,RC00039,RC02545,RC02728,RC02729,RC02931,RC02932,RC02947	ko00000,ko00001,ko00002,ko01004,ko01008	-	-	-	PP-binding
k59_323200_2	1235815.BAIX01000003_gene361	6.57e-30	118.0	COG0304@1|root,COG0304@2|Bacteria,4NEKC@976|Bacteroidetes,2FNDB@200643|Bacteroidia	976|Bacteroidetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_130124_1	1121405.dsmv_2189	9.41e-90	273.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2MJ60@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_911560_1	331869.BAL199_03574	1.65e-41	147.0	COG1638@1|root,COG1638@2|Bacteria,1PG0D@1224|Proteobacteria,2TTUQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_130127_1	697282.Mettu_0567	4.69e-30	118.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1XE30@135618|Methylococcales	1236|Gammaproteobacteria	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	treZ	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_130127_2	76114.ebA6232	3.34e-35	132.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,2M01C@206389|Rhodocyclales	206389|Rhodocyclales	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_651761_1	323848.Nmul_A2715	3.36e-08	54.7	COG3064@1|root,COG3064@2|Bacteria,1RKZU@1224|Proteobacteria,2WGP5@28216|Betaproteobacteria,372CU@32003|Nitrosomonadales	28216|Betaproteobacteria	D	TolA C-terminal	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
k59_651761_2	1163617.SCD_n00674	4.19e-56	179.0	COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Pfam Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_778291_1	396588.Tgr7_2629	1.55e-51	172.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1WX3R@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_162607_1	1238425.J07HQW2_03283	1.33e-07	54.3	arCOG06187@1|root,arCOG06187@2157|Archaea,2XTSP@28890|Euryarchaeota,23S9E@183963|Halobacteria	183963|Halobacteria	D	COG1077 Actin-like ATPase involved in cell morphogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_227061_1	96561.Dole_3250	1.45e-101	310.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_455266_1	322710.Avin_00520	1.16e-78	254.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_227069_1	595460.RRSWK_02125	4.99e-45	167.0	COG1357@1|root,COG1511@1|root,COG2931@1|root,COG3291@1|root,COG1357@2|Bacteria,COG1511@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,2IZ0P@203682|Planctomycetes	203682|Planctomycetes	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Laminin_G_3
k59_419054_1	96561.Dole_0451	6.88e-143	417.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria,2MHXY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	dsrK	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_880097_1	1125973.JNLC01000010_gene1201	7.02e-12	64.3	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria,3JSDR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_880097_2	1089552.KI911559_gene378	6.23e-30	112.0	COG5488@1|root,COG5488@2|Bacteria,1NPQQ@1224|Proteobacteria,2UB81@28211|Alphaproteobacteria,2JTP1@204441|Rhodospirillales	204441|Rhodospirillales	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
k59_651793_1	1054213.HMPREF9946_02869	6.77e-51	172.0	COG0596@1|root,COG0596@2|Bacteria,1P092@1224|Proteobacteria,2UV5T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_651793_2	288000.BBta_5810	4.34e-38	140.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,3JT6H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Malic enzyme, NAD binding domain	MA20_02490	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_162635_1	1121106.JQKB01000004_gene2407	1.02e-53	177.0	COG0684@1|root,COG0684@2|Bacteria,1MUES@1224|Proteobacteria,2U0IC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Demethylmenaquinone methyltransferase	MA20_26380	-	-	-	-	-	-	-	-	-	-	-	RraA-like
k59_63961_1	338969.Rfer_4238	1.54e-49	176.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,4AABC@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_227090_1	138119.DSY0339	3.09e-13	74.7	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,249R9@186801|Clostridia	1239|Firmicutes	T	Histidine kinase	nreB	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,PAS,PAS_9
k59_419065_1	610130.Closa_1949	2.9e-47	168.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,21ZEU@1506553|Lachnoclostridium	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_162647_2	460265.Mnod_4690	9.37e-37	137.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JU2Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM transcriptional regulator domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
k59_778336_1	1265505.ATUG01000002_gene2129	1.51e-121	353.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,42PAQ@68525|delta/epsilon subdivisions,2WKN9@28221|Deltaproteobacteria,2MKJR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM amidohydrolase 2	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_358615_1	1229909.NSED_02375	4.61e-40	148.0	COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
k59_483819_1	1177181.T9A_01401	1.17e-69	228.0	COG3017@1|root,COG3662@1|root,COG3017@2|Bacteria,COG3662@2|Bacteria,1R50Q@1224|Proteobacteria,1RQJN@1236|Gammaproteobacteria,1XNT1@135619|Oceanospirillales	135619|Oceanospirillales	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236,LolB
k59_619586_1	1502851.FG93_02000	3.69e-130	377.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_483824_1	1380387.JADM01000014_gene4116	9.19e-81	252.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RS8E@1236|Gammaproteobacteria,1XIGN@135619|Oceanospirillales	135619|Oceanospirillales	I	COG3000 Sterol desaturase	-	-	1.14.19.20	ko:K00227	ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130	M00101,M00102	R07215,R07486,R07491,R07505	RC00904	ko00000,ko00001,ko00002,ko01000	-	-	-	FA_hydroxylase
k59_619588_1	330214.NIDE3728	1.34e-82	256.0	COG0820@1|root,COG0820@2|Bacteria,3J0CH@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
k59_540203_1	247633.GP2143_14336	1.18e-68	219.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria,1J81T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.156,4.2.1.42,5.1.2.2,5.5.1.25	ko:K01781,ko:K20023,ko:K20549	ko00053,ko00627,ko01120,map00053,map00627,map01120	-	R03791,R04161,R05608	RC00543,RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_1010338_1	1532557.JL37_00800	1.27e-71	227.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2VS4Y@28216|Betaproteobacteria,3T6BJ@506|Alcaligenaceae	28216|Betaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_911658_1	977880.RALTA_B1495	8.84e-76	250.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1K6SR@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_323315_1	768671.ThimaDRAFT_2344	3.02e-47	170.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1027929_1	1122185.N792_07230	8.72e-41	152.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,1X52V@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_358659_1	228410.NE2480	3.35e-73	241.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,372B6@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	dppF	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_194849_1	222984.JNCS01000001_gene2284	4.53e-15	79.0	COG4948@1|root,arCOG01168@2157|Archaea,2XTSG@28890|Euryarchaeota,23SSG@183963|Halobacteria	183963|Halobacteria	M	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_455359_1	637390.AFOH01000043_gene2228	1.55e-09	57.8	COG0732@1|root,COG0732@2|Bacteria,1R5XE@1224|Proteobacteria,1T6EU@1236|Gammaproteobacteria,2NDF5@225057|Acidithiobacillales	225057|Acidithiobacillales	V	Type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
k59_485456_1	1460635.JCM19038_714	9.41e-28	113.0	COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,4HAWT@91061|Bacilli	91061|Bacilli	V	proteins, homologs of microcin C7 resistance protein MccF	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
k59_1012124_2	330214.NIDE0434	6.43e-85	258.0	COG1686@1|root,COG1686@2|Bacteria,3J179@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_420830_1	1125863.JAFN01000001_gene3248	6.11e-28	116.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_780067_1	859657.RPSI07_mp1355	6.87e-31	127.0	COG4585@1|root,COG4585@2|Bacteria,1R1TC@1224|Proteobacteria,2VJRQ@28216|Betaproteobacteria,1K8QQ@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA_3
k59_325414_1	94624.Bpet1409	2.96e-18	84.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_1012149_1	358681.BBR47_51560	2.42e-43	157.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,4HDFT@91061|Bacilli,26VWX@186822|Paenibacillaceae	91061|Bacilli	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_913473_1	983917.RGE_43450	1.29e-203	575.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1KJ65@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxyl transferase domain	accB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_780085_1	1121377.KB906404_gene2877	1.86e-33	131.0	COG0515@1|root,COG0515@2|Bacteria,1WIDK@1297|Deinococcus-Thermus	1121377.KB906404_gene2877|-	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_325434_1	506534.Rhein_1575	3.28e-50	179.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,1RQS2@1236|Gammaproteobacteria,1WY1F@135613|Chromatiales	135613|Chromatiales	I	PFAM Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_913490_2	1229487.AMYW01000002_gene1553	6.94e-12	65.1	arCOG09486@1|root,2ZC3Y@2|Bacteria,4NNUF@976|Bacteroidetes,1I367@117743|Flavobacteriia,2NWZT@237|Flavobacterium	976|Bacteroidetes	S	Glycosyl transferase family 11	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_11
k59_780093_1	2340.JV46_03730	1.3e-88	271.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1J543@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_283827_1	1249627.D779_2237	1.59e-106	325.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales	135613|Chromatiales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_1012180_2	1187851.A33M_2606	2.57e-58	190.0	COG0559@1|root,COG0559@2|Bacteria,1R5JM@1224|Proteobacteria,2TUSY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1012192_1	1288494.EBAPG3_8200	7.34e-115	342.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,371PY@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_325480_1	234267.Acid_0177	4.38e-83	261.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_325492_2	1279019.ARQK01000056_gene318	3.29e-11	63.5	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1WYZZ@135613|Chromatiales	135613|Chromatiales	I	PFAM Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_325539_1	767434.Fraau_1596	8.65e-75	231.0	COG3293@1|root,COG3293@2|Bacteria,1N13W@1224|Proteobacteria,1SB65@1236|Gammaproteobacteria,1XCUQ@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_526707_1	1163617.SCD_n03033	2.21e-29	119.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_168674_1	1123320.KB889640_gene4375	9.69e-31	117.0	COG0346@1|root,COG0346@2|Bacteria,2GM8H@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.25	ko:K16049	ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220	-	R04597	RC01610	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_168674_2	1184609.KILIM_026_00400	4.07e-07	52.8	2A6YK@1|root,30VTJ@2|Bacteria,2IJ81@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_461521_1	224911.27356468	1.13e-101	304.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JVIU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_658592_1	266264.Rmet_0726	8.75e-06	50.4	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,1K30S@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_658592_2	926569.ANT_09960	2.47e-75	235.0	COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_298850_1	1001530.BACE01000029_gene3753	1.82e-50	175.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1XTVH@135623|Vibrionales	135623|Vibrionales	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_5453_1	243233.MCA1693	1.31e-54	178.0	COG2913@1|root,COG2913@2|Bacteria,1RDAX@1224|Proteobacteria,1SIDU@1236|Gammaproteobacteria,1XH0J@135618|Methylococcales	135618|Methylococcales	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_526711_1	156889.Mmc1_1104	8.93e-72	225.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG3000 Sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_625636_1	522306.CAP2UW1_3923	1.1e-114	336.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,1KQ3X@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_526712_2	1007105.PT7_1944	4.81e-23	95.5	28IHQ@1|root,2Z8IX@2|Bacteria,1PX3U@1224|Proteobacteria,2VWXF@28216|Betaproteobacteria,3T997@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
k59_755306_1	543728.Vapar_5958	5.31e-68	226.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2VHSJ@28216|Betaproteobacteria,4ACTV@80864|Comamonadaceae	28216|Betaproteobacteria	V	TIGRFAM type I secretion system ATPase	-	-	-	ko:K06148,ko:K12536	ko02010,map02010	M00328	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1,3.A.1.110	-	-	ABC_membrane,ABC_tran
k59_103390_1	330214.NIDE0304	2.39e-34	129.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3J11K@40117|Nitrospirae	40117|Nitrospirae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_103390_2	861299.J421_3620	7.75e-59	189.0	COG0745@1|root,COG0745@2|Bacteria,1ZT8B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_266575_1	1229205.BUPH_03945	5.4e-146	412.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,1JZYT@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
k59_168707_1	1121033.AUCF01000030_gene160	2.58e-37	127.0	COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,2UC3P@28211|Alphaproteobacteria,2JTZR@204441|Rhodospirillales	204441|Rhodospirillales	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
k59_331832_1	330214.NIDE0755	3.38e-49	172.0	COG0768@1|root,COG0768@2|Bacteria,3J0FH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_364263_1	1279019.ARQK01000035_gene1554	1.01e-33	124.0	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_298874_1	1167006.UWK_02848	2.5e-23	98.6	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MR6@68525|delta/epsilon subdivisions,2WITP@28221|Deltaproteobacteria,2MHTE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_853979_1	314278.NB231_13251	3.41e-17	80.1	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RCFZ@1224|Proteobacteria,1S2QS@1236|Gammaproteobacteria,1X1B9@135613|Chromatiales	135613|Chromatiales	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_853979_2	1429916.X566_00575	1.16e-60	192.0	COG3415@1|root,COG3415@2|Bacteria,1RDMQ@1224|Proteobacteria,2U7PU@28211|Alphaproteobacteria,3K38Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,HTH_33
k59_136129_1	644801.Psest_2346	4.85e-20	87.4	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RS50@1236|Gammaproteobacteria,1Z0W7@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	tauC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_136129_2	948106.AWZT01000001_gene5234	8.05e-59	189.0	COG1116@1|root,COG1116@2|Bacteria,1MWZG@1224|Proteobacteria,2VNXX@28216|Betaproteobacteria,1JZNJ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_919764_1	930169.B5T_01411	4.82e-26	104.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1XHWW@135619|Oceanospirillales	135619|Oceanospirillales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_593096_1	292415.Tbd_0072	8.19e-38	130.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2VR9X@28216|Betaproteobacteria,1KT8U@119069|Hydrogenophilales	119069|Hydrogenophilales	K	transcriptional regulator AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_593096_2	477228.YO5_04287	4.15e-52	169.0	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,1S8HH@1236|Gammaproteobacteria,1Z2SH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	K	heme biosynthesis protein	nirG	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_201249_1	9371.XP_004701933.1	0.000621	46.6	COG0666@1|root,KOG0504@2759|Eukaryota,39T7I@33154|Opisthokonta,3BI1R@33208|Metazoa,3D00G@33213|Bilateria,483RH@7711|Chordata,48UU3@7742|Vertebrata,3J68I@40674|Mammalia,353TF@311790|Afrotheria	33208|Metazoa	S	Ankyrin repeat and SOCS box	ASB1	GO:0000003,GO:0000151,GO:0001817,GO:0001818,GO:0003006,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0007275,GO:0007548,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016567,GO:0019222,GO:0019538,GO:0022414,GO:0030539,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032446,GO:0032501,GO:0032502,GO:0032991,GO:0036211,GO:0042035,GO:0042036,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046661,GO:0048513,GO:0048519,GO:0048523,GO:0048608,GO:0048731,GO:0048806,GO:0048856,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051239,GO:0051241,GO:0051246,GO:0051248,GO:0060255,GO:0061458,GO:0065007,GO:0070647,GO:0071704,GO:0080090,GO:1901564,GO:1902494,GO:1990234	-	ko:K10323	-	-	-	-	ko00000,ko04121	-	-	-	Ank_2,Ank_3,Ank_4,SOCS_box
k59_103414_1	1122951.ATUE01000005_gene2107	2.04e-47	164.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,3NJY2@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Aminotran_3
k59_103414_2	396595.TK90_2251	7.37e-18	80.1	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales	135613|Chromatiales	V	PFAM N-acetylmuramoyl-L-alanine amidase family 2	-	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
k59_526716_2	1123368.AUIS01000005_gene447	5.51e-140	418.0	COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,2NBSM@225057|Acidithiobacillales	225057|Acidithiobacillales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_526716_3	1454004.AW11_00539	1.81e-42	152.0	COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,2VPY4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_38112_1	1415778.JQMM01000001_gene518	2.43e-21	92.0	COG1575@1|root,COG1575@2|Bacteria,1PKCZ@1224|Proteobacteria,1SXAN@1236|Gammaproteobacteria,1J9HU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
k59_38112_2	1415778.JQMM01000001_gene519	1.31e-31	115.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	ngr	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_3241	Flavin_Reduct,Rubrerythrin
k59_266617_1	84531.JMTZ01000038_gene3588	5.49e-22	91.7	2EFPP@1|root,339FP@2|Bacteria,1NA60@1224|Proteobacteria,1SH3I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
k59_886393_1	391038.Bphy_0030	1.19e-83	265.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,1JZXA@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_952234_1	595537.Varpa_2456	2.64e-87	275.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,4A9VY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_495474_1	1266925.JHVX01000004_gene1240	1.88e-13	71.6	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,372GZ@32003|Nitrosomonadales	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_495474_2	935836.JAEL01000034_gene4420	2.83e-18	83.6	COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,4H9UT@91061|Bacilli,1ZCDW@1386|Bacillus	91061|Bacilli	V	ABC transporter, ATP-binding protein	yxdL	-	-	ko:K11635	ko02020,map02020	M00315	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.134.6	-	-	ABC_tran
k59_5517_1	96561.Dole_1988	1.17e-51	176.0	COG0394@1|root,COG0655@1|root,COG0394@2|Bacteria,COG0655@2|Bacteria,1NANP@1224|Proteobacteria,42Q16@68525|delta/epsilon subdivisions,2WIJ7@28221|Deltaproteobacteria,2MIC1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,LMWPc
k59_461582_1	1452718.JBOY01000147_gene652	1.45e-54	182.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	dcaF	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_886398_1	388467.A19Y_3175	3.86e-68	218.0	COG2307@1|root,COG2307@2|Bacteria,1G05F@1117|Cyanobacteria,1H8SU@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Bacterial domain of	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_723790_1	279714.FuraDRAFT_1514	1.64e-71	239.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,2KQ33@206351|Neisseriales	206351|Neisseriales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_723790_2	279714.FuraDRAFT_1515	2.89e-118	351.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2VJ1V@28216|Betaproteobacteria,2KPCT@206351|Neisseriales	206351|Neisseriales	C	Nitrate reductase, beta subunit	-	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
k59_6365_3	1123508.JH636442_gene4266	4.11e-29	108.0	COG2128@1|root,COG2128@2|Bacteria,2IZDY@203682|Planctomycetes	203682|Planctomycetes	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_692117_1	436308.Nmar_0285	2.05e-131	392.0	COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_496275_1	444859.E3SI15_9CAUD	4.01e-74	238.0	4QAJD@10239|Viruses,4QW4M@35237|dsDNA viruses  no RNA stage,4QQ7U@28883|Caudovirales,4QIAP@10662|Myoviridae	10662|Myoviridae	S	gp32 DNA binding protein like	-	GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704	-	-	-	-	-	-	-	-	-	-	-
k59_496275_2	1357423.S5MB15_9CAUD	3.77e-41	145.0	4QC69@10239|Viruses,4QWAY@35237|dsDNA viruses  no RNA stage,4QPPC@28883|Caudovirales,4QHVU@10662|Myoviridae	10662|Myoviridae	S	T4 gene Gp59 loader of gp41 DNA helicase	-	GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704	-	-	-	-	-	-	-	-	-	-	-
k59_496275_3	268746.Q58N03_BPPRM	3.23e-08	53.1	4QHYU@10662|Myoviridae	10662|Myoviridae	S	Pfam:Trans_coact	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_496275_6	595536.ADVE02000001_gene3071	4.31e-20	94.4	COG3409@1|root,COG3409@2|Bacteria,1QW68@1224|Proteobacteria,2UD65@28211|Alphaproteobacteria,370HA@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_496275_7	710686.Mycsm_05224	0.000828	46.2	COG3409@1|root,COG3409@2|Bacteria,2GT5Y@201174|Actinobacteria,23CGS@1762|Mycobacteriaceae	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_169580_1	530564.Psta_3379	1.22e-98	301.0	COG1509@1|root,COG1509@2|Bacteria,2IYGS@203682|Planctomycetes	203682|Planctomycetes	C	lysine 2,3-aminomutase	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,LAM_C,Radical_SAM
k59_136988_1	1049564.TevJSym_bu00100	6.66e-49	159.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1J4SH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_136988_2	202952.BBLI01000003_gene384	1.15e-41	140.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,3NJ44@468|Moraxellaceae	1236|Gammaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_462230_1	702113.PP1Y_Mpl4	9.13e-27	102.0	COG3415@1|root,COG3415@2|Bacteria,1RDMQ@1224|Proteobacteria,2U7PU@28211|Alphaproteobacteria,2K4QQ@204457|Sphingomonadales	204457|Sphingomonadales	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,HTH_33
k59_462230_2	1522072.IL54_2353	9.94e-113	324.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,2K3Y4@204457|Sphingomonadales	204457|Sphingomonadales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_462230_3	1219045.BV98_001502	5.84e-70	213.0	COG3415@1|root,COG3415@2|Bacteria,1N7CS@1224|Proteobacteria,2UFAY@28211|Alphaproteobacteria,2K586@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
k59_594007_1	497321.C664_08548	2.24e-87	268.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,2KUHY@206389|Rhodocyclales	206389|Rhodocyclales	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_38968_1	1144312.PMI09_01682	2.16e-57	186.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2TT9I@28211|Alphaproteobacteria,4B892@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Phosphatidate cytidylyltransferase	cdsA2	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_920675_1	1121935.AQXX01000143_gene4284	3.24e-26	106.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RS2E@1236|Gammaproteobacteria,1XR33@135619|Oceanospirillales	135619|Oceanospirillales	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_920675_2	1163407.UU7_11120	7.27e-23	94.0	COG2839@1|root,COG2839@2|Bacteria,1MZEV@1224|Proteobacteria,1SAFY@1236|Gammaproteobacteria,1X6YB@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
k59_887212_1	1288494.EBAPG3_350	5.2e-70	216.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,3732A@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Transcriptional regulator	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_527114_1	977880.RALTA_B0731	2.52e-80	254.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2VKTY@28216|Betaproteobacteria,1K11H@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
k59_462232_1	290315.Clim_2069	2.05e-106	327.0	COG2989@1|root,COG2989@2|Bacteria,1FEJK@1090|Chlorobi	1090|Chlorobi	S	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_692158_1	335543.Sfum_2958	4.47e-102	308.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2MRBW@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_561517_1	330214.NIDE2461	1.17e-56	186.0	COG1561@1|root,COG1561@2|Bacteria,3J0QJ@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_561517_2	1162668.LFE_0962	1.58e-28	110.0	COG0194@1|root,COG0194@2|Bacteria,3J0JT@40117|Nitrospirae	40117|Nitrospirae	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_299724_1	497321.C664_11330	1.02e-94	281.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,2KUNS@206389|Rhodocyclales	206389|Rhodocyclales	S	ABC-type (Unclassified) transport system, ATPase component	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_267537_1	314345.SPV1_11301	3.64e-76	234.0	COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria	1224|Proteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_920693_1	999423.HMPREF9161_00156	1.54e-05	46.6	COG0780@1|root,COG0780@2|Bacteria,1TPYC@1239|Firmicutes,4H3ZI@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_594029_1	644282.Deba_1534	6.83e-67	218.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_169622_1	7668.SPU_022296-tr	1.44e-92	303.0	COG5059@1|root,KOG1075@1|root,KOG0242@2759|Eukaryota,KOG1075@2759|Eukaryota,38GPV@33154|Opisthokonta,3BF94@33208|Metazoa,3CWIA@33213|Bilateria	33208|Metazoa	Z	microtubule motor activity	KIF22	GO:0000070,GO:0000278,GO:0000280,GO:0000775,GO:0000776,GO:0000785,GO:0000819,GO:0000902,GO:0000904,GO:0001654,GO:0001756,GO:0001966,GO:0002376,GO:0002478,GO:0002495,GO:0002504,GO:0003002,GO:0003674,GO:0003676,GO:0003677,GO:0003774,GO:0003777,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0005871,GO:0005875,GO:0006810,GO:0006890,GO:0006928,GO:0006996,GO:0007017,GO:0007018,GO:0007049,GO:0007059,GO:0007062,GO:0007080,GO:0007275,GO:0007389,GO:0007399,GO:0007409,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009605,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009952,GO:0009987,GO:0015630,GO:0016043,GO:0016192,GO:0016462,GO:0016604,GO:0016607,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019882,GO:0019884,GO:0019886,GO:0021952,GO:0021953,GO:0021954,GO:0021955,GO:0022008,GO:0022402,GO:0030030,GO:0030154,GO:0030182,GO:0031175,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032989,GO:0032990,GO:0032991,GO:0035282,GO:0040011,GO:0042330,GO:0043009,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0048002,GO:0048193,GO:0048285,GO:0048468,GO:0048513,GO:0048592,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050000,GO:0050896,GO:0051179,GO:0051234,GO:0051276,GO:0051303,GO:0051310,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0060322,GO:0060429,GO:0061053,GO:0061564,GO:0070013,GO:0071840,GO:0072686,GO:0090596,GO:0097159,GO:0098687,GO:0098813,GO:0120036,GO:0120039,GO:0140014,GO:1901363,GO:1903047	-	ko:K02988,ko:K10403	ko03010,ko04914,map03010,map04914	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04812	-	-	-	HHH_3,Kinesin
k59_659571_1	76114.ebA6232	4.84e-117	353.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,2M01C@206389|Rhodocyclales	206389|Rhodocyclales	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_462245_1	446470.Snas_5218	0.000201	47.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4EZMZ@85014|Glycomycetales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_985391_1	1042163.BRLA_c017260	7.78e-07	56.2	COG0508@1|root,COG0508@2|Bacteria,1TQSH@1239|Firmicutes,4HBSU@91061|Bacilli,26SPG@186822|Paenibacillaceae	91061|Bacilli	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	bkdB	-	2.3.1.12,2.3.1.168	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	M00036,M00307	R00209,R02569,R02662,R03174,R04097,R10998	RC00004,RC02727,RC02742,RC02857,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_202158_1	1123508.JH636442_gene4074	8.6e-74	233.0	COG2055@1|root,COG2055@2|Bacteria,2J36Z@203682|Planctomycetes	203682|Planctomycetes	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
k59_202158_2	118168.MC7420_1119	7.75e-25	100.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	cypM_2	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
k59_430448_1	1117647.M5M_14405	4.36e-48	160.0	COG3431@1|root,COG3431@2|Bacteria,1RJWK@1224|Proteobacteria,1S2UP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	PsiE
k59_756043_1	1131553.JIBI01000053_gene28	3.97e-60	207.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,3725T@32003|Nitrosomonadales	28216|Betaproteobacteria	NU	type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GAF,T2SSE,T2SSE_N
k59_462249_1	1111728.ATYS01000009_gene571	3.27e-81	246.0	COG0671@1|root,COG0671@2|Bacteria,1QFZ7@1224|Proteobacteria,1S190@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
k59_365172_1	1089551.KE386572_gene2972	1.04e-143	421.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_927594_1	378806.STAUR_6282	2.21e-211	593.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2YU8Q@29|Myxococcales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_503219_1	1485544.JQKP01000001_gene1259	1.35e-34	128.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,44UYT@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_503219_2	279714.FuraDRAFT_2879	1.26e-26	98.2	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,2KRZ9@206351|Neisseriales	206351|Neisseriales	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
k59_111115_1	631362.Thi970DRAFT_04432	1.27e-71	229.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales	135613|Chromatiales	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_600812_1	909663.KI867150_gene2885	1.5e-106	337.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MQUP@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Hydrophobe amphiphile Efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_272973_1	748280.NH8B_3832	1.99e-40	144.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,2KQ7D@206351|Neisseriales	206351|Neisseriales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_339459_1	305700.B447_18828	3.86e-69	232.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales	206389|Rhodocyclales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_699280_1	338969.Rfer_2533	5.08e-112	329.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VK4X@28216|Betaproteobacteria,4AE55@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_13440_1	768671.ThimaDRAFT_2143	1.63e-28	114.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WWA8@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_991952_1	1286093.C266_20334	2.61e-91	281.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHQD@28216|Betaproteobacteria,1K09N@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde dehydrogenase	betB	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_78833_1	323848.Nmul_A2692	2.66e-97	298.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,371SR@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_78833_2	1288494.EBAPG3_8910	2.7e-33	124.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2VH9V@28216|Betaproteobacteria,3722K@32003|Nitrosomonadales	28216|Betaproteobacteria	T	PhoH-like protein	ybeZ	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_176437_1	1123256.KB907959_gene483	1.28e-57	190.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1X3WY@135614|Xanthomonadales	135614|Xanthomonadales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_861447_1	1123367.C666_14720	2.97e-63	204.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,2KVEN@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_699296_1	1379698.RBG1_1C00001G0623	3.2e-93	280.0	COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	ybhF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_761568_1	1235798.C817_05291	3.26e-159	468.0	COG1321@1|root,COG1321@2|Bacteria,1UZX6@1239|Firmicutes,248DA@186801|Clostridia	186801|Clostridia	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_960208_1	762376.AXYL_02444	1.12e-08	56.2	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,3T2WJ@506|Alcaligenaceae	28216|Betaproteobacteria	O	cytochrome c biogenesis	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_960208_2	335283.Neut_0060	2.04e-66	205.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,3731F@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_960208_3	153948.NAL212_1560	8.4e-14	66.2	COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,2VY1Y@28216|Betaproteobacteria,373N5@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
k59_960208_4	159087.Daro_3993	5.8e-09	57.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,2KV1K@206389|Rhodocyclales	206389|Rhodocyclales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
k59_208770_1	1274374.CBLK010000003_gene3219	3.13e-21	99.4	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,4HAVB@91061|Bacilli,26TAI@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 65, N-terminal domain	-	-	2.4.1.64,5.4.2.6	ko:K01838,ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727,R02728,R11310	RC00049,RC00408	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
k59_568445_2	378806.STAUR_0763	7.41e-41	143.0	COG0500@1|root,COG2226@2|Bacteria,1RC36@1224|Proteobacteria,42UDA@68525|delta/epsilon subdivisions,2WQHW@28221|Deltaproteobacteria,2YV8X@29|Myxococcales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_503263_1	641491.DND132_0693	1.03e-95	303.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,42QJC@68525|delta/epsilon subdivisions,2WPI2@28221|Deltaproteobacteria,2M9VY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_10,TPR_16,TPR_19,TPR_4,TPR_8
k59_568451_1	987059.RBXJA2T_07538	3.96e-69	214.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,2VRQX@28216|Betaproteobacteria,1KKN6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
k59_699309_1	515635.Dtur_0233	9.41e-92	280.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_437247_1	1038859.AXAU01000003_gene5956	5.11e-91	276.0	COG0583@1|root,COG0583@2|Bacteria,1R51E@1224|Proteobacteria,2TZIK@28211|Alphaproteobacteria,3JW8F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_239575_1	857087.Metme_4023	1.18e-87	267.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1XDRT@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_402855_1	1454004.AW11_03689	3.37e-102	310.0	2C8FN@1|root,2ZBER@2|Bacteria,1RK02@1224|Proteobacteria,2WG0U@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_830121_2	1288494.EBAPG3_10630	1.49e-60	191.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,2VUK7@28216|Betaproteobacteria,3733G@32003|Nitrosomonadales	28216|Betaproteobacteria	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
k59_111453_1	420324.KI911999_gene8064	3.54e-81	262.0	28JZZ@1|root,2Z9PZ@2|Bacteria,1N3C6@1224|Proteobacteria,2TSCX@28211|Alphaproteobacteria,1JTZB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_111453_2	452662.SJA_C1-13550	5.37e-76	248.0	COG0654@1|root,COG0654@2|Bacteria,1MX9R@1224|Proteobacteria,2TR4U@28211|Alphaproteobacteria,2K3D6@204457|Sphingomonadales	204457|Sphingomonadales	CH	FAD binding domain	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_437259_1	926569.ANT_25420	3.77e-92	281.0	COG0148@1|root,COG0148@2|Bacteria,2G5VB@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_79153_1	1122134.KB893650_gene1428	1.5e-21	89.7	COG2128@1|root,COG2128@2|Bacteria,1PC51@1224|Proteobacteria,1RS2U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_79153_2	365046.Rta_27470	3.8e-45	152.0	COG2128@1|root,COG2128@2|Bacteria,1QKTS@1224|Proteobacteria,2VWVV@28216|Betaproteobacteria,4AIAM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_503573_1	1144342.PMI40_02396	8.8e-13	68.9	COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,474DW@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	TIGRFAM phasin family protein	phaP	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
k59_568763_1	1280947.HY30_11505	1.61e-37	135.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,43X6N@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	COG0846 NAD-dependent protein deacetylases, SIR2 family	MA20_30275	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_176754_1	420662.Mpe_A2574	1.58e-22	94.7	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,1KKXW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome bd terminal oxidase subunit II	cioB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_176754_2	1458275.AZ34_13680	1.88e-26	108.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,4AAGK@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_893960_1	697282.Mettu_3886	2.49e-79	270.0	COG1749@1|root,COG2319@1|root,COG2372@1|root,COG1749@2|Bacteria,COG2319@2|Bacteria,COG2372@2|Bacteria,1MWJA@1224|Proteobacteria,1S1AJ@1236|Gammaproteobacteria,1XF66@135618|Methylococcales	135618|Methylococcales	N	WD40 repeat, subgroup	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,WD40
k59_861777_1	1173026.Glo7428_1327	5.25e-54	187.0	COG0318@1|root,COG0318@2|Bacteria,1G2H0@1117|Cyanobacteria	1117|Cyanobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_46098_1	261292.Nit79A3_1670	2.3e-110	332.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,372BM@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_601176_1	644107.SL1157_3330	3.41e-123	371.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,4NA93@97050|Ruegeria	28211|Alphaproteobacteria	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
k59_787983_1	1071085.KK033114_gene134	9.65e-68	223.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTGR@28890|Euryarchaeota,23SE9@183963|Halobacteria	183963|Halobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_830154_1	1188252.AJYK01000057_gene330	8.22e-94	282.0	COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,1XW39@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF541)	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
k59_633538_1	298654.FraEuI1c_3126	3.04e-29	121.0	COG2159@1|root,COG2159@2|Bacteria,2GMRC@201174|Actinobacteria	201174|Actinobacteria	I	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_601188_1	1163617.SCD_n01217	7.36e-64	197.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
k59_601188_2	338969.Rfer_1291	1.08e-09	57.8	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2VHBM@28216|Betaproteobacteria,4AAFZ@80864|Comamonadaceae	28216|Betaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_568804_1	570952.ATVH01000014_gene2234	1.08e-64	206.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,2JQID@204441|Rhodospirillales	204441|Rhodospirillales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_928010_2	1232410.KI421422_gene2036	1.42e-47	166.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,43UAU@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_468109_1	472759.Nhal_2480	2.06e-70	226.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1WXJN@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_830173_1	1485544.JQKP01000004_gene487	3.09e-89	283.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,44VNC@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	General secretory system II protein E domain protein	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GAF,T2SSE,T2SSE_N
k59_732065_1	1288494.EBAPG3_9710	9.28e-67	208.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2VHDK@28216|Betaproteobacteria,371RB@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_861816_1	1111479.AXAR01000001_gene419	1.8e-110	333.0	COG2225@1|root,COG2225@2|Bacteria,1TPE8@1239|Firmicutes,4H9ST@91061|Bacilli,279F3@186823|Alicyclobacillaceae	91061|Bacilli	C	Malate synthase	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_13860_1	1144319.PMI16_02873	1.18e-39	139.0	COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria	28216|Betaproteobacteria	S	beta-lactamase domain protein	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_601205_1	644282.Deba_1430	2.69e-53	177.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,42SJ9@68525|delta/epsilon subdivisions,2WPBC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Short chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_306364_1	1280952.HJA_05637	1.11e-07	54.3	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,43XM4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_306364_2	1123392.AQWL01000002_gene1978	1.49e-182	541.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KSKV@119069|Hydrogenophilales	119069|Hydrogenophilales	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_339865_1	1123367.C666_12150	3.41e-69	233.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales	206389|Rhodocyclales	CM	Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_46136_1	502025.Hoch_2603	3.01e-58	200.0	COG0167@1|root,COG0479@1|root,COG0167@2|Bacteria,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	1.3.1.1,1.3.1.2,1.97.1.9	ko:K00207,ko:K12527,ko:K17723	ko00240,ko00410,ko00450,ko00770,ko00983,ko01100,map00240,map00410,map00450,map00770,map00983,map01100	M00046	R00977,R00978,R01414,R01415,R07229,R08226,R11026	RC00072,RC00123,RC02245,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	ATC_hydrolase,CCG,DHO_dh,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_20,Fer4_8,Pyr_redox_2
k59_273183_1	748247.AZKH_1782	5.26e-50	174.0	COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,2VJ3A@28216|Betaproteobacteria,2KUKB@206389|Rhodocyclales	206389|Rhodocyclales	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_306367_1	497321.C664_16925	2.06e-86	263.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2VHBU@28216|Betaproteobacteria,2KUKT@206389|Rhodocyclales	206389|Rhodocyclales	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_176807_1	525897.Dbac_0165	1.37e-15	73.2	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42SIE@68525|delta/epsilon subdivisions,2WP8B@28221|Deltaproteobacteria,2MG7H@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_176807_2	1121405.dsmv_2919	4.21e-51	164.0	COG4109@1|root,COG4109@2|Bacteria,1N96M@1224|Proteobacteria,42V82@68525|delta/epsilon subdivisions,2WS7X@28221|Deltaproteobacteria,2MNU8@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
k59_402914_1	323848.Nmul_A0711	2.31e-37	136.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,372A4@32003|Nitrosomonadales	28216|Betaproteobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_861826_1	1116472.MGMO_224c00010	2.38e-34	120.0	2A022@1|root,30N4C@2|Bacteria,1PU9F@1224|Proteobacteria,1SCMU@1236|Gammaproteobacteria,1XFRM@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF1840)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1840
k59_633574_1	1115515.EV102420_06_00350	4.73e-39	141.0	2AXQF@1|root,31PR8@2|Bacteria,1RKX8@1224|Proteobacteria,1S6JS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_894011_1	1268622.AVS7_01010	6.14e-10	59.7	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VINW@28216|Betaproteobacteria,4ACAN@80864|Comamonadaceae	28216|Betaproteobacteria	E	ABC transporter	livF_15	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_894011_2	429009.Adeg_1595	5.77e-25	105.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,42ESB@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998,ko:K11961	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_830195_1	204773.HEAR2693	3.74e-10	61.6	COG2867@1|root,COG2867@2|Bacteria,1QUZA@1224|Proteobacteria,2VUHS@28216|Betaproteobacteria,4750S@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_830195_2	717785.HYPMC_3287	4.02e-12	65.9	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
k59_273185_2	797209.ZOD2009_07199	4.35e-29	118.0	COG0602@1|root,arCOG02173@2157|Archaea,2XUSP@28890|Euryarchaeota,23SEF@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_732097_1	391596.PBAL39_12097	1.68e-18	86.3	COG4108@1|root,COG4108@2|Bacteria,4NFEZ@976|Bacteroidetes,1IP50@117747|Sphingobacteriia	976|Bacteroidetes	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_732097_2	1217714.F975_01163	1.33e-17	82.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,3NIZR@468|Moraxellaceae	1236|Gammaproteobacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934	DAHP_synth_1
k59_601225_1	159087.Daro_1746	1.87e-44	151.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,2KV64@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_601225_2	1158292.JPOE01000002_gene2162	1.6e-83	251.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,1KJGT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_601225_3	1288494.EBAPG3_800	4.59e-121	351.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2VH8A@28216|Betaproteobacteria,372KJ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_601225_4	511.JT27_13410	3.64e-06	48.1	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,3T31G@506|Alcaligenaceae	28216|Betaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_830212_1	1096546.WYO_2549	5.3e-177	499.0	COG3415@1|root,COG3415@2|Bacteria,1QWK4@1224|Proteobacteria,2TX0C@28211|Alphaproteobacteria,1JS18@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k59_894027_1	1442599.JAAN01000034_gene789	5.73e-77	242.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,1RQHG@1236|Gammaproteobacteria,1X4ZM@135614|Xanthomonadales	135614|Xanthomonadales	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve
k59_568857_1	1163617.SCD_n00803	7.91e-50	168.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2VQNY@28216|Betaproteobacteria	28216|Betaproteobacteria	H	lipoate-protein ligase A	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_239659_1	330214.NIDE0302	1.43e-99	302.0	COG0621@1|root,COG0621@2|Bacteria,3J0CD@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_837069_1	436308.Nmar_0196	4.9e-65	199.0	arCOG05565@1|root,arCOG05565@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_52487_1	1122939.ATUD01000001_gene538	7.81e-30	115.0	COG4976@1|root,COG4976@2|Bacteria,2H4WU@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_312366_1	314345.SPV1_06939	2.6e-140	412.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c45100	ThiC-associated,ThiC_Rad_SAM
k59_150871_2	262724.TT_P0070	7.42e-34	125.0	COG1030@1|root,COG1030@2|Bacteria,1WKAY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_640100_1	243159.AFE_2083	4.49e-64	210.0	COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,1S04A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_473595_1	1287116.X734_15365	4.39e-20	87.0	COG5573@1|root,COG5573@2|Bacteria,1N454@1224|Proteobacteria,2UDGY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_473595_2	1379270.AUXF01000002_gene1303	1.36e-11	61.2	2DR3J@1|root,33A0M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_576550_2	387631.Asulf_00213	1.62e-05	48.1	COG0446@1|root,arCOG01064@2157|Archaea,2XUFE@28890|Euryarchaeota,2460V@183980|Archaeoglobi	183980|Archaeoglobi	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_246090_1	1459636.NTE_00986	1.72e-51	170.0	COG2085@1|root,arCOG00457@2157|Archaea,41SH2@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_246090_2	1459636.NTE_00985	2.65e-16	73.6	arCOG08823@1|root,arCOG08823@2157|Archaea,41SW2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_576560_2	945713.IALB_0305	3.8e-23	90.9	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_86958_1	671143.DAMO_0754	3.66e-63	209.0	COG0260@1|root,COG0260@2|Bacteria,2NNKH@2323|unclassified Bacteria	2|Bacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.4.11.1,3.4.11.5	ko:K01255,ko:K01259	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00135,R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_86963_1	795666.MW7_2489	1.31e-64	206.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,1K6K1@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_216550_1	1120936.KB907219_gene3171	7.51e-14	77.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4EG9Z@85012|Streptosporangiales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_576568_1	685778.AORL01000010_gene2833	1.03e-18	88.2	COG0702@1|root,COG0702@2|Bacteria,1RCCP@1224|Proteobacteria,2TU1D@28211|Alphaproteobacteria,2K0TF@204457|Sphingomonadales	204457|Sphingomonadales	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_576568_2	349741.Amuc_2146	4.76e-21	89.0	COG0720@1|root,COG0720@2|Bacteria,46VC9@74201|Verrucomicrobia,2IVQQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_935829_1	1454004.AW11_00516	2.6e-47	165.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_935829_2	1123257.AUFV01000001_gene1836	5.09e-10	59.7	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1X78G@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
k59_999843_1	665571.STHERM_c21600	1.52e-185	535.0	COG1274@1|root,COG1274@2|Bacteria,2J5BB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_21535_2	436308.Nmar_1792	5.45e-91	282.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k59_968464_1	994479.GL877881_gene6541	8.01e-11	62.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,2I98A@201174|Actinobacteria,4E0T5@85010|Pseudonocardiales	201174|Actinobacteria	KP	PFAM Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Rhodanese
k59_968464_2	1283300.ATXB01000001_gene110	6.56e-20	87.8	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1XEP6@135618|Methylococcales	135618|Methylococcales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_641103_1	945713.IALB_0262	3.37e-31	120.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_641103_2	945713.IALB_0263	1.57e-47	170.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K07710,ko:K10942	ko02020,ko05111,map02020,map05111	M00500,M00515	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
k59_313305_1	987059.RBXJA2T_07623	3.45e-113	343.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,1KJPX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_21545_1	76114.ebA6435	5.15e-69	213.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VK6R@28216|Betaproteobacteria,2KVYG@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4
k59_246135_1	1131814.JAFO01000001_gene2097	1.49e-18	94.4	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	DUF4407,MMPL,Peptidase_S46,Wzz
k59_347425_1	1122218.KB893653_gene1271	8.52e-36	126.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria,1JTVP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_347425_2	1120983.KB894570_gene1404	1.64e-14	72.0	COG1495@1|root,COG1495@2|Bacteria,1RKPG@1224|Proteobacteria,2U89W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Disulfide bond formation protein DsbB	-	-	-	-	-	-	-	-	-	-	-	-	DsbB
k59_511340_1	56780.SYN_01645	1.72e-96	306.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_641112_1	472759.Nhal_2491	1.53e-61	213.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales	135613|Chromatiales	G	alpha amylase catalytic	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_444714_1	1123367.C666_06410	5.18e-80	263.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales	206389|Rhodocyclales	NT	Methyl-accepting chemotaxis protein	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_674826_1	246194.CHY_1732	3.87e-43	157.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42I2K@68295|Thermoanaerobacterales	186801|Clostridia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_184195_1	247634.GPB2148_1605	4.56e-40	140.0	COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,1J6CJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	s cog2930	CT2216	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_740052_1	1231391.AMZF01000036_gene2989	8.11e-23	98.2	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,3T1KZ@506|Alcaligenaceae	28216|Betaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_740052_2	1304883.KI912532_gene1565	1.24e-22	90.5	COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,2KWVG@206389|Rhodocyclales	206389|Rhodocyclales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
k59_740052_3	640081.Dsui_0243	3.09e-25	105.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,2KUNQ@206389|Rhodocyclales	206389|Rhodocyclales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_474501_1	502025.Hoch_4227	0.000683	47.4	COG1716@1|root,COG1716@2|Bacteria,1RAA4@1224|Proteobacteria,431UR@68525|delta/epsilon subdivisions,2WWZQ@28221|Deltaproteobacteria,2YU65@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,FHA,Yop-YscD_cpl
k59_869514_1	450851.PHZ_c1055	4.44e-61	209.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2KFFV@204458|Caulobacterales	204458|Caulobacterales	P	Haloacid dehalogenase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_968507_1	1121861.KB899928_gene1508	5.86e-58	193.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JQGA@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_313343_2	572477.Alvin_1747	1.64e-23	94.7	2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria,1WYYH@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_119268_1	457421.CBFG_03608	7.35e-26	107.0	COG3391@1|root,COG3391@2|Bacteria,1V092@1239|Firmicutes,25BMV@186801|Clostridia	1239|Firmicutes	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
k59_740084_1	395494.Galf_1043	1.89e-12	65.1	COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,2VUJ4@28216|Betaproteobacteria,44VWY@713636|Nitrosomonadales	28216|Betaproteobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
k59_740084_2	159087.Daro_0750	1.38e-60	189.0	COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2VSK1@28216|Betaproteobacteria,2KWN2@206389|Rhodocyclales	206389|Rhodocyclales	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
k59_409435_1	330214.NIDE3354	5.16e-32	120.0	COG0005@1|root,COG0005@2|Bacteria,3J0HC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_409435_2	330214.NIDE3353	1.34e-127	369.0	COG0524@1|root,COG0524@2|Bacteria,3J0ZT@40117|Nitrospirae	40117|Nitrospirae	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
k59_277002_1	1366050.N234_33785	7.69e-08	52.8	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_277002_2	640081.Dsui_3054	1.28e-109	323.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,2KVUM@206389|Rhodocyclales	206389|Rhodocyclales	P	phosphate transport system	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_999901_1	1288494.EBAPG3_27690	5.72e-83	267.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,371PH@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Soluble lytic murein transglycosylase L domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_347470_1	1229909.NSED_07075	1.48e-76	237.0	COG0206@1|root,arCOG02201@2157|Archaea,41SG8@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Tubulin/FtsZ family, GTPase domain	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	Tubulin
k59_935905_2	426114.THI_1186	3.4e-21	92.8	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,1KJFK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	acetylornithine	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_21596_1	105559.Nwat_0513	1.61e-197	560.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1WW9C@135613|Chromatiales	135613|Chromatiales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_707659_1	3988.XP_002535387.1	1.68e-20	90.9	COG1502@1|root,2RKKV@2759|Eukaryota,382RH@33090|Viridiplantae,3GS34@35493|Streptophyta	35493|Streptophyta	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	iECED1_1282.ECED1_0754	PLDc_2
k59_707659_2	1123392.AQWL01000001_gene1370	1.89e-19	84.3	2EC4Z@1|root,3363S@2|Bacteria,1N9YG@1224|Proteobacteria,2W41I@28216|Betaproteobacteria,1KTCV@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_740099_1	484018.BACPLE_03274	2.42e-48	171.0	COG3172@1|root,COG3172@2|Bacteria,4NEQF@976|Bacteroidetes,2FN8P@200643|Bacteroidia,4AMSQ@815|Bacteroidaceae	976|Bacteroidetes	H	COG NOG06391 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	DUF4301
k59_791057_1	330214.NIDE3284	1.58e-62	215.0	COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,3J117@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,PAS_4
k59_347480_1	1150626.PHAMO_20098	1.91e-46	155.0	COG0607@1|root,COG0607@2|Bacteria,1RJQ6@1224|Proteobacteria,2VFUG@28211|Alphaproteobacteria,2JUIN@204441|Rhodospirillales	204441|Rhodospirillales	M	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_474542_1	1125863.JAFN01000001_gene3206	4.96e-38	142.0	COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_313364_1	330214.NIDE3556	2.94e-63	197.0	COG0720@1|root,COG0720@2|Bacteria	2|Bacteria	H	synthase	ygcM	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_313364_2	330214.NIDE3555	1.63e-65	205.0	COG0302@1|root,COG0302@2|Bacteria,3J0Q0@40117|Nitrospirae	40117|Nitrospirae	F	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_534569_1	472759.Nhal_3813	1.41e-46	154.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales	135613|Chromatiales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
k59_87063_1	1123399.AQVE01000007_gene1137	1.57e-69	228.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,4629A@72273|Thiotrichales	72273|Thiotrichales	P	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_474545_1	266264.Rmet_3668	4.61e-99	291.0	COG2057@1|root,COG2057@2|Bacteria,1MWW1@1224|Proteobacteria,2VIBE@28216|Betaproteobacteria,1K086@119060|Burkholderiaceae	28216|Betaproteobacteria	I	TIGRFAM 3-oxoacid CoA-transferase, B subunit	pcaJ	-	2.8.3.6	ko:K01032	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_474545_2	688245.CtCNB1_0685	1.13e-14	72.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2VIR2@28216|Betaproteobacteria,4AAYG@80864|Comamonadaceae	28216|Betaproteobacteria	I	TIGRFAM 3-oxoacid CoA-transferase, A subunit	pcaI	-	2.8.3.6	ko:K01031	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_707674_1	1229909.NSED_08400	2.45e-15	80.5	arCOG07561@1|root,arCOG07561@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TSP_3,VWA
k59_869551_1	1366050.N234_19810	1.08e-55	196.0	COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,1K1ZV@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	general secretion pathway protein D	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_999930_1	1459636.NTE_02622	1.69e-61	190.0	COG0316@1|root,arCOG04560@2157|Archaea,41SKH@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Iron-sulfur cluster assembly accessory protein	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_409464_1	1392838.AWNM01000037_gene1054	2.62e-31	124.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,3T309@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_968559_1	1123401.JHYQ01000044_gene910	7.66e-08	55.8	COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,1S3E7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5,Acyltransferase
k59_53546_1	1123060.JONP01000002_gene931	7.37e-13	68.6	COG2085@1|root,COG2085@2|Bacteria,1RCXR@1224|Proteobacteria,2UDQV@28211|Alphaproteobacteria,2JUR8@204441|Rhodospirillales	204441|Rhodospirillales	S	Rossmann-like domain	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_707691_1	1304885.AUEY01000004_gene994	9.55e-79	241.0	COG2602@1|root,COG2602@2|Bacteria,1NWXE@1224|Proteobacteria,42QWH@68525|delta/epsilon subdivisions,2WP3H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Penicillin binding protein transpeptidase domain	-	-	3.5.2.6	ko:K17838	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Transpeptidase
k59_838233_1	153948.NAL212_0449	5.15e-39	147.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,3724W@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_838233_2	580332.Slit_0988	1.28e-75	246.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria,44W55@713636|Nitrosomonadales	28216|Betaproteobacteria	P	von Willebrand factor (vWF) type A domain	cbbO	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
k59_999942_1	1163617.SCD_n00952	1.96e-138	408.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_216671_1	1094508.Tsac_1128	5.21e-66	206.0	COG0454@1|root,COG0454@2|Bacteria,1V3SX@1239|Firmicutes,24G4B@186801|Clostridia	186801|Clostridia	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_791072_1	926569.ANT_21170	1.49e-09	63.5	COG4974@1|root,COG4974@2|Bacteria,2G8U5@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_869575_1	1304885.AUEY01000010_gene1690	1.11e-68	227.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MHP4@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_246220_1	1206741.BAFX01000005_gene5873	2.62e-60	199.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4FUVB@85025|Nocardiaceae	201174|Actinobacteria	Q	cytochrome P450	cyp51	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0008398,GO:0016125,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0032451,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0055114,GO:0070988,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901615	1.14.13.70	ko:K05917	ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130	M00101	R05640,R05731	RC01442	ko00000,ko00001,ko00002,ko00199,ko01000	-	-	-	p450
k59_246220_2	1206729.BAFZ01000060_gene3596	1.53e-17	76.6	COG1141@1|root,COG1141@2|Bacteria,2GS47@201174|Actinobacteria,4G3V5@85025|Nocardiaceae	201174|Actinobacteria	C	Divergent 4Fe-4S mono-cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13,Fer4_15
k59_246220_3	247156.NFA_25840	7.98e-13	65.9	28NTV@1|root,2ZBSB@2|Bacteria,2GS03@201174|Actinobacteria,4FUR6@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_747302_2	1122604.JONR01000009_gene2310	1.8e-26	110.0	COG2208@1|root,COG4252@1|root,COG2208@2|Bacteria,COG4252@2|Bacteria,1MXJQ@1224|Proteobacteria,1RQIY@1236|Gammaproteobacteria,1X49K@135614|Xanthomonadales	135614|Xanthomonadales	KT	methyl-accepting chemotaxis protein	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,HATPase_c_2,SpoIIE,dCache_1
k59_60183_1	1305732.JAGG01000001_gene2059	3.98e-26	105.0	COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4FKAA@85023|Microbacteriaceae	201174|Actinobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_94230_1	857087.Metme_1830	1e-52	189.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1XGNR@135618|Methylococcales	135618|Methylococcales	P	PFAM Cation H exchanger	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_845485_1	391626.OAN307_63p00390	5.22e-73	229.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TT5Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_385894_1	228410.NE2323	4.18e-57	188.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2VHYP@28216|Betaproteobacteria,3720J@32003|Nitrosomonadales	28216|Betaproteobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_1025840_1	1336245.JAGO01000015_gene2004	3.06e-07	53.1	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1XJVP@135619|Oceanospirillales	135619|Oceanospirillales	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1025840_2	998088.B565_2356	1.04e-12	70.1	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1Y5IX@135624|Aeromonadales	135624|Aeromonadales	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_319632_1	279714.FuraDRAFT_1385	1.2e-135	393.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,2VIUT@28216|Betaproteobacteria,2KQAU@206351|Neisseriales	206351|Neisseriales	K	RNA polymerase sigma factor	rpoS	-	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_714847_1	384765.SIAM614_23492	2.54e-06	51.2	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
k59_907897_1	365528.KB891159_gene5397	5.51e-37	140.0	COG0438@1|root,COG0438@2|Bacteria,2GX8V@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_518595_1	365046.Rta_32010	1.06e-16	79.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,4ACKS@80864|Comamonadaceae	28216|Betaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
k59_518595_2	1300345.LF41_1761	1.38e-53	171.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,1X72V@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_518598_2	1430440.MGMSRv2_3777	7.59e-52	175.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2JQHW@204441|Rhodospirillales	204441|Rhodospirillales	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_60220_1	4538.ORGLA05G0020200.1	6.69e-08	56.2	COG4992@1|root,KOG1401@2759|Eukaryota,37JRF@33090|Viridiplantae,3GBNS@35493|Streptophyta,3KQ1V@4447|Liliopsida,3IBVS@38820|Poales	35493|Streptophyta	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	GO:0003674,GO:0003824,GO:0003992,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0006950,GO:0006952,GO:0007275,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0022622,GO:0030170,GO:0032501,GO:0032502,GO:0036094,GO:0042742,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044419,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048037,GO:0048364,GO:0048731,GO:0048856,GO:0050662,GO:0050896,GO:0051704,GO:0051707,GO:0070279,GO:0071704,GO:0080022,GO:0097159,GO:0098542,GO:0099402,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.11	ko:K00818	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02283	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_60220_2	323848.Nmul_A1042	1.41e-57	188.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,371NM@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1006619_1	666686.B1NLA3E_12665	6.31e-05	45.1	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,4HASX@91061|Bacilli,1ZBFM@1386|Bacillus	91061|Bacilli	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iYO844.BSU38550	Aminotran_4
k59_1006619_2	945713.IALB_0491	4.43e-60	191.0	COG0767@1|root,COG0767@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_451486_1	1464048.JNZS01000020_gene2256	4.68e-44	160.0	COG1409@1|root,COG1409@2|Bacteria,2IM97@201174|Actinobacteria,4D9VR@85008|Micromonosporales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Metallophos
k59_158846_1	247634.GPB2148_3472	8.55e-101	306.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1J4HM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125	GATase_6,Pribosyltran
k59_126212_1	686340.Metal_3173	1.05e-39	158.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales	135618|Methylococcales	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,MASE1,PAS_3,PAS_9
k59_518607_2	309801.trd_A0672	1.11e-06	50.4	COG0714@1|root,COG0714@2|Bacteria,2GANG@200795|Chloroflexi,27Y4P@189775|Thermomicrobia	189775|Thermomicrobia	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1025857_1	373903.Hore_06780	1.81e-125	367.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,3WBK2@53433|Halanaerobiales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	vorB	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_615761_1	580332.Slit_1294	2.41e-64	202.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2VRM9@28216|Betaproteobacteria,44VRI@713636|Nitrosomonadales	28216|Betaproteobacteria	F	Phosphoribosyl transferase domain	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_615761_2	765914.ThisiDRAFT_0455	7.83e-45	147.0	COG2044@1|root,COG2044@2|Bacteria,1RGWS@1224|Proteobacteria,1SE6E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE,DrsE_2
k59_975863_1	1499967.BAYZ01000113_gene2936	9.79e-100	296.0	COG0081@1|root,COG0081@2|Bacteria,2NNK6@2323|unclassified Bacteria	2|Bacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_682160_1	179408.Osc7112_5633	1.05e-68	227.0	COG0366@1|root,COG0366@2|Bacteria,1G0NX@1117|Cyanobacteria,1H7KE@1150|Oscillatoriales	1117|Cyanobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_20
k59_648051_1	1157708.KB907468_gene103	2.73e-10	61.6	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VNJN@28216|Betaproteobacteria,4ACBA@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_648051_2	1037409.BJ6T_36720	8.57e-56	186.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,3JT4Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	MA20_43260	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_126213_1	6087.XP_004211536.1	1.41e-45	173.0	2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2,Endonuclease_7
k59_518609_1	1068980.ARVW01000001_gene4892	1.27e-43	157.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4DYHU@85010|Pseudonocardiales	201174|Actinobacteria	Q	cytochrome P450	-	-	-	ko:K21164	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002	-	-	-	p450
k59_28592_1	977880.RALTA_A1076	3.03e-70	224.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,1K1EX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_319669_2	483219.LILAB_17770	2.29e-56	189.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ28@28221|Deltaproteobacteria,2YWA0@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II/IV secretion system protein	pilT-1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_319670_1	1267534.KB906757_gene956	2.11e-10	67.4	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase,Trans_reg_C,WD40
k59_415585_1	416591.Tlet_1142	1.13e-60	198.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
k59_907930_2	1112209.AHVZ01000015_gene2430	3.65e-112	332.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,3NK12@468|Moraxellaceae	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase, middle domain	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_584021_1	863365.XHC_0256	4.44e-16	79.7	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMXI@1236|Gammaproteobacteria,1X3Q6@135614|Xanthomonadales	135614|Xanthomonadales	E	Dipeptidyl carboxypeptidase	dcp2	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_451503_1	945713.IALB_1435	1.15e-112	342.0	COG0441@1|root,COG0441@2|Bacteria	2|Bacteria	J	threonyl-tRNA aminoacylation	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_385949_1	443254.Marpi_1461	1.14e-07	53.1	COG0399@1|root,COG0399@2|Bacteria,2GCGX@200918|Thermotogae	200918|Thermotogae	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_385949_2	925409.KI911562_gene137	1.01e-15	80.5	28JDJ@1|root,2Z97V@2|Bacteria,4NJ02@976|Bacteroidetes	976|Bacteroidetes	S	Capsule assembly protein Wzi	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
k59_714893_1	1288494.EBAPG3_25940	5.61e-56	188.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,372X1@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	Sugar (and other) transporter	yajR	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_714893_2	859657.RPSI07_2983	3.32e-14	69.3	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,1K2Q6@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_126226_2	330214.NIDE4188	1.04e-25	105.0	28J7E@1|root,2Z92U@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
k59_793833_1	335283.Neut_1570	2.2e-54	182.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2VJEV@28216|Betaproteobacteria,371MR@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51,4.2.1.91,5.4.99.5	ko:K01713,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_682178_1	337191.KTR9_2340	4.11e-12	70.9	COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria,4GB6S@85026|Gordoniaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_94296_1	1207075.PputUW4_03127	6.26e-11	70.1	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_190958_2	1123261.AXDW01000010_gene298	9.39e-21	95.1	COG4638@1|root,COG4638@2|Bacteria,1N3CA@1224|Proteobacteria,1S0V7@1236|Gammaproteobacteria,1X4YE@135614|Xanthomonadales	135614|Xanthomonadales	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_252304_1	247634.GPB2148_140	5.28e-46	159.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,1RRRV@1236|Gammaproteobacteria,1J55K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_747380_1	765913.ThidrDRAFT_1101	2.18e-23	106.0	COG3598@1|root,COG3598@2|Bacteria,1PWN4@1224|Proteobacteria,1T47X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25
k59_354520_1	1255043.TVNIR_3070	6.63e-95	288.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1WZYG@135613|Chromatiales	135613|Chromatiales	G	Fructose-bisphosphate aldolase class-I	-	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_876442_1	414684.RC1_1317	6.66e-11	62.8	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria,2JQEF@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_876442_2	640081.Dsui_2808	8.97e-46	161.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VIJ8@28216|Betaproteobacteria,2KVRS@206389|Rhodocyclales	206389|Rhodocyclales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_876444_2	1123367.C666_02955	8.02e-25	98.6	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,2KVGG@206389|Rhodocyclales	206389|Rhodocyclales	S	synthesis repressor, PhaR	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
k59_451531_1	1127673.GLIP_0459	2.69e-16	83.2	COG3386@1|root,COG3386@2|Bacteria,1QAGP@1224|Proteobacteria,1RTQI@1236|Gammaproteobacteria,46BKS@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_480498_1	1485544.JQKP01000023_gene867	3.25e-66	214.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,44VGF@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_975907_1	1123393.KB891333_gene2538	5.17e-86	263.0	COG0664@1|root,COG0664@2|Bacteria,1RAF3@1224|Proteobacteria,2VQIC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
k59_354538_1	224911.27356358	9.5e-110	325.0	COG0605@1|root,COG0607@1|root,COG0605@2|Bacteria,COG0607@2|Bacteria,1R4Z3@1224|Proteobacteria,2U38P@28211|Alphaproteobacteria,3JT9I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Iron/manganese superoxide dismutases, C-terminal domain	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Rhodanese,Sod_Fe_C
k59_60284_1	436308.Nmar_0290	8.56e-86	263.0	COG3875@1|root,arCOG02046@2157|Archaea,41SK4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_252338_1	1236959.BAMT01000004_gene915	2.73e-11	59.7	COG3165@1|root,COG3165@2|Bacteria	2|Bacteria	S	ubiquinone biosynthetic process from chorismate	yigP	GO:0006082,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0019752,GO:0032150,GO:0042180,GO:0042181,GO:0043436,GO:0043648,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046417,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
k59_252338_2	323848.Nmul_A0988	9.68e-63	207.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,3723G@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_907978_1	1122604.JONR01000001_gene1775	1.03e-66	217.0	COG0596@1|root,COG0596@2|Bacteria,1NDHC@1224|Proteobacteria,1SM95@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_94348_1	1349767.GJA_3091	3.59e-50	182.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,473K1@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Linear gramicidin synthase subunit	-	-	6.3.2.14	ko:K02364	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
k59_682234_1	1123487.KB892836_gene3266	2.74e-23	98.6	COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VHDQ@28216|Betaproteobacteria,2KW16@206389|Rhodocyclales	206389|Rhodocyclales	T	response regulator	mmoQ	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HDOD,Response_reg
k59_416474_2	261292.Nit79A3_2480	4.96e-41	150.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VJ6T@28216|Betaproteobacteria,372WA@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3501
k59_29587_1	886293.Sinac_2176	1.62e-28	121.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_794163_2	330214.NIDE3736	6e-86	273.0	COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae	2|Bacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046820,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_616773_1	1266925.JHVX01000017_gene23	1.68e-99	307.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,371QX@32003|Nitrosomonadales	28216|Betaproteobacteria	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_775756_1	1168065.DOK_16963	4.56e-18	84.3	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1J5V1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction protein with a C-terminal ATPase domain	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_775756_2	713586.KB900537_gene3330	1.42e-25	101.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1WY8N@135613|Chromatiales	135613|Chromatiales	KT	Response regulator of the LytR AlgR family	-	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_95306_1	1232410.KI421412_gene169	6.06e-73	231.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,43SYA@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_67787_1	180281.CPCC7001_1979	1.68e-56	191.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,22SI1@167375|Cyanobium	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_67787_2	469383.Cwoe_1063	7.66e-14	71.2	COG1233@1|root,COG1233@2|Bacteria,2IE6C@201174|Actinobacteria	201174|Actinobacteria	Q	FAD dependent oxidoreductase	crtO	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_818752_2	1121918.ARWE01000001_gene1112	4.35e-27	106.0	COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2WIRR@28221|Deltaproteobacteria,43S9X@69541|Desulfuromonadales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_590080_1	522772.Dacet_2901	1.88e-41	150.0	COG0282@1|root,COG0282@2|Bacteria,2GF56@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_328819_1	1162668.LFE_0880	1.14e-96	292.0	COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae	40117|Nitrospirae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_916679_1	265072.Mfla_1057	5.85e-110	340.0	COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,2KKG4@206350|Nitrosomonadales	206350|Nitrosomonadales	T	His Kinase A (phospho-acceptor) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_916679_2	1173028.ANKO01000164_gene2743	1.44e-30	116.0	COG2234@1|root,COG2234@2|Bacteria,1G1QW@1117|Cyanobacteria,1H7N7@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_981558_1	457570.Nther_2823	8.82e-30	119.0	COG0613@1|root,COG0613@2|Bacteria,1VINF@1239|Firmicutes,24SJB@186801|Clostridia	186801|Clostridia	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
k59_720651_1	66373.JOFQ01000003_gene5820	4.63e-19	90.9	COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria	201174|Actinobacteria	I	fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_981564_1	706587.Desti_3169	1.1e-132	389.0	COG0683@1|root,COG0683@2|Bacteria,1MXPJ@1224|Proteobacteria,42NFF@68525|delta/epsilon subdivisions,2WKDK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Amino acid amide ABC transporter substrate-binding protein, HAAT family	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_35114_1	1121035.AUCH01000003_gene1192	9.96e-31	123.0	COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMT1@28216|Betaproteobacteria,2KUZ5@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N_2
k59_100346_1	1122223.KB890700_gene2078	1.01e-85	266.0	COG1012@1|root,COG1012@2|Bacteria,1WK1N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_524785_1	1163617.SCD_n01089	6.98e-84	252.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria	1224|Proteobacteria	E	Glycine cleavage system	gcvR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
k59_949090_1	566466.NOR53_2328	2.14e-65	205.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1J9J6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	KR domain	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0030497,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1093,iAPECO1_1312.APECO1_174,iBWG_1329.BWG_0941,iE2348C_1286.E2348C_1185,iEC55989_1330.EC55989_1205,iECABU_c1320.ECABU_c13060,iECDH10B_1368.ECDH10B_1165,iECDH1ME8569_1439.ECDH1ME8569_1028,iECED1_1282.ECED1_1236,iECIAI39_1322.ECIAI39_2068,iECNA114_1301.ECNA114_1150,iECO103_1326.ECO103_1138,iECOK1_1307.ECOK1_1200,iECP_1309.ECP_1085,iECS88_1305.ECS88_1107,iECSE_1348.ECSE_1157,iECSF_1327.ECSF_0992,iECUMN_1333.ECUMN_1268,iECW_1372.ECW_m1201,iEKO11_1354.EKO11_2741,iETEC_1333.ETEC_1158,iEcDH1_1363.EcDH1_2554,iEcE24377_1341.EcE24377A_1214,iEcHS_1320.EcHS_A1215,iEcSMS35_1347.EcSMS35_2034,iEcolC_1368.EcolC_2508,iG2583_1286.G2583_1353,iJN746.PP_1914,iJO1366.b1093,iJR904.b1093,iSBO_1134.SBO_1970,iSFV_1184.SFV_1113,iSF_1195.SF1097,iSFxv_1172.SFxv_1249,iSSON_1240.SSON_1113,iS_1188.S1177,iSbBS512_1146.SbBS512_E2231,iUMN146_1321.UM146_11860,iUMNK88_1353.UMNK88_1363,iUTI89_1310.UTI89_C1218,iWFL_1372.ECW_m1201,iY75_1357.Y75_RS05710	adh_short_C2
k59_949090_2	247639.MGP2080_11713	5.7e-38	128.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,1J6RD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_393905_1	1123274.KB899406_gene984	9.38e-05	50.1	COG1053@1|root,COG3976@1|root,COG1053@2|Bacteria,COG3976@2|Bacteria,2J5TN@203691|Spirochaetes	203691|Spirochaetes	C	Fumarate reductase succinate dehydrogenase flavoprotein	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
k59_655489_2	264732.Moth_1909	1.73e-51	182.0	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,42FDP@68295|Thermoanaerobacterales	186801|Clostridia	C	Formate dehydrogenase alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_328843_1	76114.ebA4892	1.33e-75	236.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHGM@28216|Betaproteobacteria,2KVQ7@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_622738_1	1229909.NSED_07115	3.97e-28	115.0	COG2132@1|root,COG3391@1|root,COG3794@1|root,arCOG02562@2157|Archaea,arCOG02926@2157|Archaea,arCOG03914@2157|Archaea	2157|Archaea	Q	Multicopper	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
k59_2330_1	7425.NV30603-PA	1.65e-17	92.8	2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,41XP3@6656|Arthropoda,3SQGB@50557|Insecta	33208|Metazoa	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2,Endonuclease_7
k59_459177_2	330214.NIDE3757	3.82e-42	146.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_655495_1	330214.NIDE1727	8.49e-133	386.0	COG0484@1|root,COG0484@2|Bacteria,3J0A7@40117|Nitrospirae	40117|Nitrospirae	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_393915_1	1132855.KB913035_gene1798	4.88e-39	144.0	COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2VI0A@28216|Betaproteobacteria,2KKQT@206350|Nitrosomonadales	206350|Nitrosomonadales	N	TIGRFAM flagellar motor switch protein FliM	-	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
k59_492296_1	443144.GM21_2798	5.77e-73	240.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
k59_949106_1	543913.D521_1362	4.21e-18	89.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,1KQQV@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_35142_1	83406.HDN1F_32990	1.46e-69	223.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,1RSCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Saccharopine dehydrogenase	lys	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
k59_590121_1	436308.Nmar_0564	1.84e-47	156.0	COG1607@1|root,arCOG00773@2157|Archaea	436308.Nmar_0564|-	I	Acyl-CoA hydrolase	-	-	4.3.1.14	ko:K18014	ko00310,map00310	-	R03030	RC00833	ko00000,ko00001,ko01000	-	-	-	-
k59_688203_2	1229909.NSED_01665	1.06e-51	163.0	COG2012@1|root,arCOG04258@2157|Archaea,41SU8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
k59_688203_3	1229909.NSED_01670	9.16e-07	49.3	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_916741_1	1121930.AQXG01000001_gene1272	4.95e-06	50.1	COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1IQN0@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_916741_2	521393.JH806632_gene307	4.02e-23	90.9	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4D5YH@85005|Actinomycetales	201174|Actinobacteria	J	Ribosomal protein L31	rpmE2	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_492315_2	1396141.BATP01000003_gene5192	5.45e-33	122.0	2EGH2@1|root,33A95@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4375
k59_165707_1	1177154.Y5S_02233	2.07e-49	160.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1XKH7@135619|Oceanospirillales	135619|Oceanospirillales	P	protein affecting Mg2 Co2 transport	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_459200_1	936455.KI421499_gene340	1.02e-67	236.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_655526_1	1229909.NSED_07800	3.39e-36	127.0	arCOG08772@1|root,arCOG08772@2157|Archaea,41SSX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_655526_2	1229909.NSED_07795	9.44e-35	126.0	COG0104@1|root,arCOG04387@2157|Archaea,41SCA@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_655528_1	861299.J421_1944	4.7e-61	206.0	COG0659@1|root,COG0659@2|Bacteria,1ZTYW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	Sulfate_transp
k59_720719_1	468059.AUHA01000006_gene3015	1.05e-61	204.0	COG0534@1|root,COG0534@2|Bacteria,4NDUF@976|Bacteroidetes,1IQJT@117747|Sphingobacteriia	976|Bacteroidetes	V	Mate efflux family protein	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_133126_1	945713.IALB_3175	1.39e-35	141.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_16,TPR_8
k59_688235_2	1340493.JNIF01000003_gene2605	1.83e-14	76.6	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	FHA,VWA,VWA_2
k59_328893_1	177437.HRM2_37580	8.8e-09	53.9	COG1146@1|root,COG1146@2|Bacteria,1NJJD@1224|Proteobacteria,42VKY@68525|delta/epsilon subdivisions,2WRXE@28221|Deltaproteobacteria,2MKYB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7
k59_328893_2	926569.ANT_29420	2e-11	64.7	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_557611_1	255470.cbdbA1487	1.22e-132	383.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_557611_2	717785.HYPMC_3459	3.57e-36	124.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_820163_2	880073.Calab_1319	5.77e-34	127.0	COG1249@1|root,COG1249@2|Bacteria,2NQMY@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3)	lpdA	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019464,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0036211,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045250,GO:0045252,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0097159,GO:0106077,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_1869,iEcolC_1368.EcolC_3543,iPC815.YPO3417,iSFV_1184.SFV_0107,iUMN146_1321.UM146_23385	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_362658_1	1304885.AUEY01000032_gene2011	6.57e-102	303.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2MI9R@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_656869_1	1397527.Q670_07025	7.39e-21	95.5	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1XINT@135619|Oceanospirillales	135619|Oceanospirillales	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_722060_1	331869.BAL199_27166	3.33e-99	298.0	COG0596@1|root,COG0596@2|Bacteria,1NJ2B@1224|Proteobacteria,2TR54@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_264983_1	439235.Dalk_4509	7.27e-86	268.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,434AT@68525|delta/epsilon subdivisions,2X9GM@28221|Deltaproteobacteria,2MNQ4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_982878_1	768066.HELO_1213	2.31e-48	173.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1XHC0@135619|Oceanospirillales	135619|Oceanospirillales	E	Oligopeptidase	prlC	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_3753_1	1121351.AUAP01000017_gene1311	6.18e-24	103.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,2KQCQ@206351|Neisseriales	206351|Neisseriales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
k59_3753_2	795666.MW7_0049	6.98e-11	62.8	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,1K23X@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_101721_1	864051.BurJ1DRAFT_2511	2.98e-104	309.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2VHSU@28216|Betaproteobacteria,1KIX9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_297346_1	582744.Msip34_2662	8.85e-63	200.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2VH1V@28216|Betaproteobacteria,2KMFB@206350|Nitrosomonadales	206350|Nitrosomonadales	K	Transcriptional regulator, Crp Fnr family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
k59_918086_1	984262.SGRA_3394	2.89e-133	405.0	COG0855@1|root,COG0855@2|Bacteria,4NE3P@976|Bacteroidetes,1IPGC@117747|Sphingobacteriia	976|Bacteroidetes	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_264997_2	671143.DAMO_0040	1.39e-62	204.0	COG0577@1|root,COG0577@2|Bacteria,2NQJU@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_591461_1	1123354.AUDR01000015_gene257	1.87e-88	266.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,1KS53@119069|Hydrogenophilales	1224|Proteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_3778_1	640081.Dsui_3223	1.86e-117	348.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,2KUVU@206389|Rhodocyclales	206389|Rhodocyclales	O	Zn-dependent protease with chaperone function	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_36475_1	1163617.SCD_n01943	1.73e-101	303.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria	28216|Betaproteobacteria	BQ	histone deacetylase	hda	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_330174_1	765912.Thimo_3378	1.33e-43	160.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW89@135613|Chromatiales	135613|Chromatiales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_167073_1	666681.M301_2336	9.69e-50	173.0	COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,PEGA
k59_134477_1	573370.DMR_37340	5.74e-55	203.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42MI4@68525|delta/epsilon subdivisions,2WKB9@28221|Deltaproteobacteria,2M9JS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K08357	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_199677_1	1159870.KB907784_gene2093	1.56e-05	46.6	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2VIHY@28216|Betaproteobacteria	28216|Betaproteobacteria	P	YidE YbjL duplication	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
k59_820214_1	1165096.ARWF01000001_gene2027	1.84e-35	130.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KKH8@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_820214_2	1034943.BN1094_03021	1.84e-07	52.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1JDD3@118969|Legionellales	118969|Legionellales	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_982922_1	1121448.DGI_0773	5.58e-53	181.0	COG0160@1|root,COG0160@2|Bacteria,1QTZ3@1224|Proteobacteria,43D42@68525|delta/epsilon subdivisions,2X8AU@28221|Deltaproteobacteria,2MHF9@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_918126_1	1318628.MARLIPOL_09159	5.95e-26	106.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria,464HZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_918126_2	1172185.KB911512_gene4870	1e-50	168.0	COG0596@1|root,COG0596@2|Bacteria,2HEMJ@201174|Actinobacteria,4FY86@85025|Nocardiaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_950537_1	794903.OPIT5_28445	9.59e-102	306.0	COG0677@1|root,COG0677@2|Bacteria	2|Bacteria	M	UDP-N-acetyl-D-mannosamine dehydrogenase activity	wbpA	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_820221_1	945713.IALB_0904	9.42e-40	134.0	COG0222@1|root,COG0222@2|Bacteria	2|Bacteria	J	mitochondrial gene expression	rplL	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_820221_2	1232437.KL662045_gene2150	7.93e-12	66.6	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MI5C@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_297381_1	1123392.AQWL01000002_gene1978	1.19e-125	391.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KSKV@119069|Hydrogenophilales	119069|Hydrogenophilales	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_591500_1	1123053.AUDG01000001_gene2433	1.63e-26	103.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,1S8Y4@1236|Gammaproteobacteria,1X1EZ@135613|Chromatiales	135613|Chromatiales	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_591500_2	571166.KI421509_gene2920	0.000122	43.9	COG2900@1|root,COG2900@2|Bacteria,1N7YP@1224|Proteobacteria,2UFXX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SlyX protein	-	-	-	ko:K03745	-	-	-	-	ko00000	-	-	-	SlyX
k59_991347_2	945543.VIBR0546_13685	2.42e-33	125.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RREX@1236|Gammaproteobacteria,1XUF6@135623|Vibrionales	135623|Vibrionales	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_371085_1	1380391.JIAS01000019_gene1302	1.45e-06	49.7	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria,2JYME@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
k59_371085_2	1333998.M2A_2787	1.15e-55	188.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,4BSZR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_761019_1	543728.Vapar_4936	1.18e-63	213.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,4A9UR@80864|Comamonadaceae	28216|Betaproteobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_860824_1	936455.KI421499_gene6040	2.43e-53	181.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TT6V@28211|Alphaproteobacteria,3JX9K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	FliO,Voltage_CLC
k59_665829_1	566466.NOR53_1905	7.79e-25	102.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,1J7X5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_467239_1	1298867.AUES01000067_gene5125	6.37e-29	120.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_893045_1	1157708.KB907475_gene1108	3.27e-89	272.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2VIGP@28216|Betaproteobacteria,4AC6E@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_12803_1	96561.Dole_1419	1.25e-94	285.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2WK12@28221|Deltaproteobacteria,2MIA2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein alpha	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_110508_1	1192034.CAP_8806	1.45e-20	95.1	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,42NU5@68525|delta/epsilon subdivisions,2WJV4@28221|Deltaproteobacteria,2YX9Q@29|Myxococcales	28221|Deltaproteobacteria	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_175813_1	330214.NIDE2563	5e-31	115.0	COG2003@1|root,COG2003@2|Bacteria,3J0HV@40117|Nitrospirae	40117|Nitrospirae	E	RadC-like JAB domain	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_175813_2	555088.DealDRAFT_2165	2.95e-24	103.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,42JHA@68298|Syntrophomonadaceae	186801|Clostridia	J	elongation factor Tu domain 2 protein	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_45126_1	1121875.KB907546_gene2194	5.35e-65	215.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_731058_1	1227739.Hsw_3198	8.55e-05	45.4	COG0644@1|root,COG0644@2|Bacteria,4NE67@976|Bacteroidetes	976|Bacteroidetes	C	fad dependent oxidoreductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
k59_731058_2	62928.azo2890	3.13e-119	354.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VHQI@28216|Betaproteobacteria,2KUHQ@206389|Rhodocyclales	206389|Rhodocyclales	E	aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_632592_1	1120972.AUMH01000022_gene619	7.39e-82	253.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,4H9MB@91061|Bacilli,27865@186823|Alicyclobacillaceae	91061|Bacilli	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_78224_1	744979.R2A130_3657	7.38e-56	182.0	COG1638@1|root,COG1638@2|Bacteria,1MUJY@1224|Proteobacteria,2TQNU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_371106_1	1123368.AUIS01000031_gene1424	1.23e-14	73.9	COG0737@1|root,COG0737@2|Bacteria,1Q977@1224|Proteobacteria,1RYXZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the 5'-nucleotidase family	yfkN	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_371106_2	1121372.AULK01000006_gene1431	8.13e-20	82.4	COG1254@1|root,COG1254@2|Bacteria,2HZJD@201174|Actinobacteria,4FQ1C@85023|Microbacteriaceae	201174|Actinobacteria	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
k59_143208_1	649638.Trad_1985	6.77e-76	243.0	COG1488@1|root,COG1488@2|Bacteria,1WIWH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
k59_238794_1	861299.J421_1112	8.92e-105	320.0	COG0534@1|root,COG0534@2|Bacteria,1ZT3Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_371107_1	1100720.ALKN01000007_gene3022	7.93e-58	197.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria,4AASY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Indolepyruvate ferredoxin oxidoreductase	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	TPP_enzyme_C
k59_371107_2	1123504.JQKD01000007_gene3334	8.24e-44	156.0	COG1014@1|root,COG1014@2|Bacteria,1MV7Q@1224|Proteobacteria,2VMSN@28216|Betaproteobacteria,4ABYN@80864|Comamonadaceae	28216|Betaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
k59_927005_1	247639.MGP2080_11863	8.86e-54	183.0	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,1S719@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_567799_1	864051.BurJ1DRAFT_1631	1.23e-47	175.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1KJ47@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_436385_1	880073.Calab_1254	8.32e-23	102.0	COG2133@1|root,COG2866@1|root,COG2133@2|Bacteria,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	manA5	-	3.2.1.51,3.2.1.78	ko:K01206,ko:K01218	ko00051,ko00511,ko02024,map00051,map00511,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH26,GH29	-	Alpha_L_fucos,CHU_C,Glyco_hydro_26,PA14
k59_600235_1	1504672.669787224	6.26e-28	109.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,4A9PY@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	yiaJ	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_600235_2	557598.LHK_02526	5.61e-52	179.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VK3W@28216|Betaproteobacteria,2KQH0@206351|Neisseriales	206351|Neisseriales	L	DNA polymerase III, epsilon subunit	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T
k59_402097_1	76114.ebA723	5.95e-95	283.0	COG1028@1|root,COG1028@2|Bacteria,1RCD5@1224|Proteobacteria,2W04R@28216|Betaproteobacteria,2KXRA@206389|Rhodocyclales	206389|Rhodocyclales	IQ	KR domain	-	-	-	ko:K07535	ko00362,ko01120,ko01220,map00362,map01120,map01220	M00540	R05582	RC00154	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
k59_402097_2	991905.SL003B_1858	1.9e-23	96.3	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria,4BRFT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	MA20_38145	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_208184_1	335543.Sfum_3755	3.07e-99	305.0	COG5421@1|root,COG5421@2|Bacteria,1Q09R@1224|Proteobacteria,437PJ@68525|delta/epsilon subdivisions,2WYMZ@28221|Deltaproteobacteria,2MRCG@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_893092_1	551275.KB899544_gene1541	3.46e-14	75.9	COG0664@1|root,COG0664@2|Bacteria,1PG8F@1224|Proteobacteria,2V8J5@28211|Alphaproteobacteria,43ZQ9@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
k59_761070_1	1453501.JELR01000001_gene2239	3.99e-48	173.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,4656T@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG2217 Cation transport ATPase	copA	GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035434,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060003,GO:0061687,GO:0070887,GO:0071241,GO:0071248,GO:0071280,GO:0071292,GO:0071944,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:1902601,GO:1990169	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iEC55989_1330.EC55989_0497,iECIAI1_1343.ECIAI1_0487,iECO103_1326.ECO103_0460,iECSE_1348.ECSE_0509,iECW_1372.ECW_m0557,iEKO11_1354.EKO11_3363,iWFL_1372.ECW_m0557	E1-E2_ATPase,HMA,Hydrolase
k59_698682_1	266264.Rmet_0174	4.82e-32	121.0	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,2VWZ9@28216|Betaproteobacteria,1KGBX@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
k59_698682_2	1095769.CAHF01000011_gene2257	1.14e-07	53.1	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,472MA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	ABC transporter	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_665897_1	640081.Dsui_2148	2.14e-77	257.0	COG4564@1|root,COG5001@1|root,COG4564@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KW14@206389|Rhodocyclales	206389|Rhodocyclales	T	Cache 3/Cache 2 fusion domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9,dCache_2
k59_436415_1	2340.JV46_14070	2.42e-36	134.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1J9KE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_436415_2	1041159.AZUW01000019_gene128	7.35e-15	73.6	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U4QB@28211|Alphaproteobacteria,4BD43@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_338888_1	864051.BurJ1DRAFT_3528	6.16e-120	357.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KJP2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_665901_1	1218084.BBJK01000086_gene5770	8.03e-30	123.0	COG4796@1|root,COG4796@2|Bacteria,1QUY7@1224|Proteobacteria,2VJ8Z@28216|Betaproteobacteria,1K5MF@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Secretin and TonB N terminus short domain	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,STN,Secretin,Secretin_N
k59_402111_1	870187.Thini_4244	1.67e-26	107.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,1RMCU@1236|Gammaproteobacteria,461XW@72273|Thiotrichales	72273|Thiotrichales	H	Cobyrinic acid A,C-diamide	-	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	CbiA,GATase_3
k59_402111_2	864051.BurJ1DRAFT_3324	6.82e-59	194.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,2VK76@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_468280_2	1089552.KI911559_gene404	2.56e-07	50.1	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2U9GJ@28211|Alphaproteobacteria,2JT01@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
k59_209334_2	1248917.ANFX01000040_gene768	5.49e-05	48.1	COG0346@1|root,COG0346@2|Bacteria,1RAC9@1224|Proteobacteria,2U65N@28211|Alphaproteobacteria,2K485@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_928241_2	323848.Nmul_A1964	4.05e-13	69.7	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,372I8@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_46365_1	388051.AUFE01000001_gene1913	3.13e-69	220.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2VIVI@28216|Betaproteobacteria	28216|Betaproteobacteria	I	2-Hydroxy-3-oxopropionate reductase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_633802_1	522306.CAP2UW1_0661	2.87e-70	219.0	COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,1KQPY@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	cAMP phosphodiesterases class-II	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_468287_1	1454004.AW11_01676	2.62e-112	333.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_928244_1	323848.Nmul_A1129	3.34e-131	381.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2VHZZ@28216|Betaproteobacteria,3729W@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_144444_1	1168065.DOK_10061	5.31e-43	154.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1J4X2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Nucleoside H+ symporter	hcaT	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_14092_1	1437882.AZRU01000059_gene4142	1.32e-43	171.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YEZ2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Signal transducing histidine kinase, homodimeric domain	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_46370_1	1167006.UWK_02176	2.66e-71	241.0	COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MICZ@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2,PPDK_N
k59_144447_1	1229909.NSED_01160	6.79e-63	197.0	COG1056@1|root,arCOG00972@2157|Archaea,41SHQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Nicotinamide-nucleotide adenylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_144447_2	436308.Nmar_0253	2.16e-103	304.0	COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota	651137|Thaumarchaeota	C	oxidoreductase FAD NAD(P)-binding	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_177041_1	1198452.Jab_2c02500	8.21e-20	88.6	COG4968@1|root,COG4968@2|Bacteria,1QUZW@1224|Proteobacteria,2WGNG@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
k59_273296_1	483219.LILAB_17265	1.26e-41	139.0	COG3436@1|root,COG3436@2|Bacteria,1PXYK@1224|Proteobacteria,43DZ7@68525|delta/epsilon subdivisions,2WZ9A@28221|Deltaproteobacteria,2Z1MK@29|Myxococcales	28221|Deltaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_503855_1	323848.Nmul_A1295	9.03e-149	425.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,37275@32003|Nitrosomonadales	28216|Betaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_46384_1	439235.Dalk_1318	3.84e-75	227.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,43BHF@68525|delta/epsilon subdivisions,2WQUJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_928265_1	396588.Tgr7_2205	1.92e-69	222.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1SEJ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored,GIDA,Lycopene_cycl
k59_601435_1	926550.CLDAP_38200	1.29e-20	95.5	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_633830_1	1323663.AROI01000013_gene245	8.86e-75	243.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_437558_1	583345.Mmol_0304	9.26e-14	68.2	COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,2W81J@28216|Betaproteobacteria,2KNBR@206350|Nitrosomonadales	206350|Nitrosomonadales	S	STAS domain	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
k59_437558_2	762376.AXYL_00195	1.36e-35	129.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,3T258@506|Alcaligenaceae	28216|Betaproteobacteria	V	ABC transporter, ATP-binding protein	ybhF_1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_894230_2	768671.ThimaDRAFT_4899	1.63e-151	446.0	COG2801@1|root,COG2801@2|Bacteria,1MUSB@1224|Proteobacteria,1RYKV@1236|Gammaproteobacteria,1X06D@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase, catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_209376_1	1504672.669785423	1.28e-85	263.0	COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2VMR1@28216|Betaproteobacteria,4AA67@80864|Comamonadaceae	28216|Betaproteobacteria	EJ	PFAM Asparaginase glutaminase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_79450_3	349741.Amuc_1497	2.66e-36	140.0	2BDDY@1|root,32730@2|Bacteria,46WKY@74201|Verrucomicrobia,2IWBU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_862076_1	1163407.UU7_10551	2.12e-26	98.2	2E5S4@1|root,330GM@2|Bacteria,1NAY4@1224|Proteobacteria,1SEIX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_862076_2	1366050.N234_12245	6.54e-23	90.5	2C19F@1|root,32TZS@2|Bacteria,1R3J6@1224|Proteobacteria,2VXS6@28216|Betaproteobacteria,1KISS@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_239849_1	580332.Slit_2564	2.23e-74	242.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2VMAN@28216|Betaproteobacteria,44WCY@713636|Nitrosomonadales	28216|Betaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_340124_1	555778.Hneap_1706	5.56e-43	142.0	COG0011@1|root,COG0011@2|Bacteria,1N1NM@1224|Proteobacteria,1SAV8@1236|Gammaproteobacteria,1WZPV@135613|Chromatiales	135613|Chromatiales	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
k59_1018748_1	870187.Thini_2393	4.36e-57	186.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,4604S@72273|Thiotrichales	72273|Thiotrichales	J	glycyl-tRNA synthetase, alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
k59_1018748_2	187272.Mlg_0011	4.64e-10	60.5	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_992608_1	436308.Nmar_0210	1.34e-34	119.0	COG0526@1|root,arCOG01972@2157|Archaea,41SSR@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_992608_2	1229909.NSED_00850	1.73e-53	173.0	arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
k59_862082_1	264198.Reut_A0685	2.35e-60	199.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,1K1V2@119060|Burkholderiaceae	28216|Betaproteobacteria	C	formate dehydrogenase	fdhC	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_928288_1	1128421.JAGA01000003_gene2905	2.76e-33	132.0	COG3011@1|root,COG3011@2|Bacteria	2|Bacteria	CH	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	LMF1
k59_762114_1	402626.Rpic_1188	2.06e-99	298.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1K25Z@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_569123_1	102107.XP_008237054.1	3.69e-08	61.2	COG0154@1|root,KOG1211@2759|Eukaryota,37RB9@33090|Viridiplantae,3G9FZ@35493|Streptophyta,4JDRP@91835|fabids	35493|Streptophyta	J	Fatty acid amide	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005783,GO:0005794,GO:0005886,GO:0006066,GO:0006576,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009308,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0012505,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0031090,GO:0034308,GO:0034641,GO:0042439,GO:0042742,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044106,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0047412,GO:0050896,GO:0051704,GO:0051707,GO:0070291,GO:0071704,GO:0071944,GO:0098542,GO:0098588,GO:0098805,GO:1901564,GO:1901615	-	-	-	-	-	-	-	-	-	-	Amidase
k59_14145_1	323848.Nmul_A2468	1.13e-99	316.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_894256_1	945713.IALB_2287	2.99e-67	211.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_209389_1	1163617.SCD_n01425	4.64e-06	48.5	2CM31@1|root,32SD0@2|Bacteria,1N2TZ@1224|Proteobacteria,2VUNK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1001704_1	452637.Oter_0854	2.44e-14	78.2	COG3291@1|root,COG3291@2|Bacteria,46Z7J@74201|Verrucomicrobia,3KA3F@414999|Opitutae	2|Bacteria	S	SMART Immunoglobulin C2 type	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,He_PIG,Ig_3,VCBS
k59_643091_1	330214.NIDE3968	5.69e-139	409.0	COG2274@1|root,COG2274@2|Bacteria	2|Bacteria	V	protein secretion by the type I secretion system	-	-	-	ko:K02021	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_578707_1	296591.Bpro_4696	7.3e-86	269.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2VI17@28216|Betaproteobacteria,4ACCU@80864|Comamonadaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_23547_1	472759.Nhal_0688	2.64e-97	296.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1WWT1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_247873_1	351348.Maqu_3115	3.39e-30	121.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,46432@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Cytochrome C and Quinol oxidase polypeptide I	norB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0055114	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_247873_2	292415.Tbd_0822	1.39e-11	68.2	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,2VNWY@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
k59_840241_1	882378.RBRH_00999	7.54e-102	310.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,1K1TI@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_446627_1	402777.KB235903_gene2403	3.16e-59	201.0	COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,1H7MX@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
k59_411171_1	2340.JV46_28850	2.73e-86	264.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1J63G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	IS30 family	ISPlu1B	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_218511_1	666681.M301_0210	2.86e-48	159.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria,2KMM5@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_381205_1	189753.AXAS01000047_gene109	1.05e-70	230.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,3JQZH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,FAD_binding_3
k59_23566_1	744979.R2A130_1662	1.22e-20	91.3	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_23566_2	420324.KI911948_gene9276	1.74e-35	126.0	COG0262@1|root,COG0262@2|Bacteria,1Q00Z@1224|Proteobacteria,2TTFQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	-	-	-	-	-	-	-	-	-	-	-	-	DHFR_1
k59_770323_1	1380390.JIAT01000009_gene1598	9.59e-61	211.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria,4CTX9@84995|Rubrobacteria	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,TPR_19
k59_903047_1	243232.MJ_1425	3.52e-39	144.0	COG2055@1|root,arCOG04874@2157|Archaea,2XVBT@28890|Euryarchaeota,23QEN@183939|Methanococci	183939|Methanococci	C	PFAM Malate L-lactate dehydrogenase	comC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464,GO:0050545	1.1.1.337	ko:K05884	ko00680,map00680	M00358	R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_2
k59_937949_1	1286632.P278_31310	1.3e-191	552.0	28HMZ@1|root,2Z7WD@2|Bacteria,4P095@976|Bacteroidetes	2|Bacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_513407_1	945713.IALB_1697	1.28e-41	148.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_513407_2	945713.IALB_1697	5.95e-15	74.3	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_791861_1	397945.Aave_2985	1.24e-55	198.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria,4AD3R@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_578726_1	1000565.METUNv1_02950	6.04e-89	275.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,2KUV1@206389|Rhodocyclales	206389|Rhodocyclales	S	modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_121993_1	497964.CfE428DRAFT_4819	4.71e-48	169.0	COG2433@1|root,COG2433@2|Bacteria,46Z8U@74201|Verrucomicrobia	2|Bacteria	S	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_350266_1	992406.RIA_0577	5.99e-62	209.0	COG3104@1|root,COG3104@2|Bacteria,4NE8R@976|Bacteroidetes,1HWTF@117743|Flavobacteriia	976|Bacteroidetes	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_792226_1	1007105.PT7_0805	1.89e-88	272.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,3T1SD@506|Alcaligenaceae	28216|Betaproteobacteria	G	C4-dicarboxylate ABC transporter permease	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_447447_1	95619.PM1_0200290	4.46e-05	45.8	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoglycolate phosphatase	gph	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756	HAD_2
k59_447447_2	987059.RBXJA2T_16537	1.47e-56	182.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,1KK6S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
k59_536005_1	323848.Nmul_A1268	3.15e-104	305.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VZ53@28216|Betaproteobacteria,374MG@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_536005_2	1163617.SCD_n02143	2.36e-12	67.4	COG1230@1|root,COG1230@2|Bacteria,1QUZ5@1224|Proteobacteria,2WGMK@28216|Betaproteobacteria	28216|Betaproteobacteria	P	cation diffusion facilitator family transporter	zitB	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Abhydrolase_6,Cation_efflux
k59_411938_1	93220.LV28_14625	1.63e-56	192.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,1K1TG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_447448_1	351746.Pput_0852	9.87e-39	144.0	COG3639@1|root,COG3639@2|Bacteria,1N3HU@1224|Proteobacteria,1TKEF@1236|Gammaproteobacteria,1YUW1@136845|Pseudomonas putida group	1236|Gammaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_677800_1	330214.NIDE3057	1.65e-93	287.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119,6.3.1.19	ko:K13571,ko:K20814	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
k59_1002538_1	1230476.C207_00724	8.43e-26	106.0	2E5W4@1|root,330K6@2|Bacteria,1N893@1224|Proteobacteria,2UGUZ@28211|Alphaproteobacteria,3JRW1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
k59_1002538_2	1410620.SHLA_38c000530	5.18e-210	590.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,4B9XR@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1002538_3	522306.CAP2UW1_2883	2.29e-76	249.0	COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1NQ5K@1224|Proteobacteria,2VPHG@28216|Betaproteobacteria	28216|Betaproteobacteria	KLT	peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
k59_841157_1	640081.Dsui_1583	1.97e-110	332.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,2KU8D@206389|Rhodocyclales	1224|Proteobacteria	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_841158_1	436308.Nmar_1497	6.32e-14	70.9	arCOG03932@1|root,arCOG03932@2157|Archaea,41SKB@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_938821_2	1158345.JNLL01000001_gene1305	4.52e-24	98.6	COG1611@1|root,COG1611@2|Bacteria,2G4BX@200783|Aquificae	200783|Aquificae	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A,Lysine_decarbox
k59_186800_1	1089552.KI911559_gene2519	5.04e-35	128.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,2JRCB@204441|Rhodospirillales	204441|Rhodospirillales	S	Elongator protein 3, MiaB family, Radical SAM	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_186800_2	1089552.KI911559_gene2518	4.81e-46	157.0	COG1575@1|root,COG1575@2|Bacteria	2|Bacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_248679_1	501479.ACNW01000058_gene4416	7.32e-75	239.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	Glutaredoxin,PALP
k59_122008_1	243160.BMAA2089	6.83e-08	55.1	COG0304@1|root,COG1028@1|root,COG3321@1|root,COG0304@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2VP69@28216|Betaproteobacteria,1KBR1@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,PS-DH,adh_short_C2,ketoacyl-synt
k59_381984_2	748247.AZKH_4132	4.6e-18	84.0	COG1989@1|root,COG1989@2|Bacteria,1R34X@1224|Proteobacteria,2WIFE@28216|Betaproteobacteria,2KXGG@206389|Rhodocyclales	206389|Rhodocyclales	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
k59_350284_1	330214.NIDE0678	2.99e-59	203.0	COG2217@1|root,COG2217@2|Bacteria,3J0CY@40117|Nitrospirae	40117|Nitrospirae	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_350284_2	330214.NIDE0681	2.73e-57	192.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_186807_1	1286106.MPL1_05389	1.24e-128	373.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,4602K@72273|Thiotrichales	72273|Thiotrichales	D	TIGRFAM Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_154781_3	1410622.JNKY01000013_gene1583	3.09e-06	50.1	COG0789@1|root,COG0789@2|Bacteria,1VF47@1239|Firmicutes,24U5Z@186801|Clostridia	186801|Clostridia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_154781_5	1121100.JCM6294_540	2.27e-52	171.0	2BVF9@1|root,32QUP@2|Bacteria,4NS32@976|Bacteroidetes,2FSIF@200643|Bacteroidia,4AR54@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_24430_2	497321.C664_17025	1.95e-52	174.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,2KU92@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_1002550_1	1288494.EBAPG3_7970	4.86e-111	334.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,372M3@32003|Nitrosomonadales	28216|Betaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_122022_1	1499967.BAYZ01000093_gene4034	5.21e-79	246.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_476960_1	85643.Tmz1t_3466	1.95e-61	209.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VIQ6@28216|Betaproteobacteria,2KUJM@206389|Rhodocyclales	206389|Rhodocyclales	K	Bacterial regulatory protein, Fis family	-	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
k59_89989_1	292415.Tbd_1295	5.23e-117	352.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	type II secretion system protein E	-	-	-	ko:K02454,ko:K02652,ko:K12276	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_186816_2	118005.AWNK01000013_gene890	9.97e-26	107.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_743008_1	1458275.AZ34_09470	6.5e-71	228.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4AAJP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_611634_2	525904.Tter_2405	1.46e-10	63.2	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_447479_2	436308.Nmar_1085	5.96e-100	318.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_411969_1	251229.Chro_0863	9.34e-79	256.0	COG3385@1|root,COG3385@2|Bacteria,1G3T3@1117|Cyanobacteria,3VMB3@52604|Pleurocapsales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_90002_1	1499967.BAYZ01000095_gene4068	1.37e-14	79.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_743024_1	1229909.NSED_02705	7.58e-76	238.0	COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota	651137|Thaumarchaeota	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
k59_743024_2	1229909.NSED_02700	3.72e-14	69.3	COG1547@1|root,arCOG03705@2157|Archaea,41SQ0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
k59_938859_1	365044.Pnap_2183	1.33e-96	308.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_710651_1	504472.Slin_0358	1.62e-95	308.0	COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,47MPU@768503|Cytophagia	976|Bacteroidetes	G	glycoside hydrolase family 2 sugar binding	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_106,Glyco_hydro_2_N
k59_611652_1	1123392.AQWL01000005_gene3007	2.22e-19	84.3	COG0589@1|root,COG0589@2|Bacteria,1N02E@1224|Proteobacteria,2VU60@28216|Betaproteobacteria,1KTAA@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_611652_2	671143.DAMO_1046	8.02e-20	84.3	COG4747@1|root,COG4747@2|Bacteria,2NR4R@2323|unclassified Bacteria	2|Bacteria	S	ACT domain protein	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00570	R00220,R00996,R01513,R01773,R01775	RC00031,RC00087,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
k59_411980_1	522306.CAP2UW1_1311	1.33e-56	184.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VM61@28216|Betaproteobacteria,1KQQ2@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein LuxR	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_872355_1	1125973.JNLC01000010_gene1416	3.97e-26	107.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,3JVJ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	MA20_17650	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_872355_2	1125973.JNLC01000011_gene592	5.59e-91	277.0	COG0673@1|root,COG0673@2|Bacteria,1QSNV@1224|Proteobacteria,2TUMB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_411986_1	330214.NIDE4326	2.4e-36	127.0	2CK1C@1|root,32SJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_411986_2	498761.HM1_1844	4.58e-22	90.1	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
k59_677864_1	1123261.AXDW01000002_gene1648	8.98e-77	242.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1X3KV@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_56186_1	313612.L8106_02422	1.22e-14	81.3	COG0823@1|root,COG1404@1|root,COG2931@1|root,COG0823@2|Bacteria,COG1404@2|Bacteria,COG2931@2|Bacteria,1GR3A@1117|Cyanobacteria,1HI6V@1150|Oscillatoriales	1117|Cyanobacteria	OQ	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,HemolysinCabind
k59_382033_1	485915.Dret_1993	1.57e-08	57.8	2EP8F@1|root,33GV5@2|Bacteria,1NM4S@1224|Proteobacteria,42WXQ@68525|delta/epsilon subdivisions,2WSJE@28221|Deltaproteobacteria,2MDVH@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_938876_2	679937.Bcop_1652	1.48e-06	57.4	COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,2FMMH@200643|Bacteroidia,4AKHX@815|Bacteroidaceae	976|Bacteroidetes	H	Acetolactate synthase, large subunit	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_804890_1	443254.Marpi_0054	2.77e-10	67.8	COG0419@1|root,COG0419@2|Bacteria,2GC4P@200918|Thermotogae	200918|Thermotogae	L	PFAM SMC domain protein	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_23,SbcCD_C
k59_1036148_1	1142394.PSMK_18310	7.67e-37	141.0	COG1178@1|root,COG1178@2|Bacteria,2J51F@203682|Planctomycetes	203682|Planctomycetes	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_551793_1	1424334.W822_22380	1.28e-37	130.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,3T3GD@506|Alcaligenaceae	28216|Betaproteobacteria	S	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ	yajQ	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_551793_2	1163617.SCD_n02187	2.29e-57	179.0	COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,2VSCI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	-	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
k59_551796_1	637905.SVI_3133	5.01e-13	74.3	COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,1RP19@1236|Gammaproteobacteria,2Q9GW@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM acetyl-CoA hydrolase transferase	-	-	-	ko:K18288	ko00660,map00660	-	R02407,R10600	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
k59_804950_1	1453501.JELR01000002_gene351	9.51e-32	117.0	2B4XH@1|root,32REP@2|Bacteria,1RJ9F@1224|Proteobacteria,1T0SV@1236|Gammaproteobacteria,46BPI@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_292522_1	1129794.C427_0258	4.71e-54	194.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1SM5J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_804971_2	1265502.KB905959_gene247	3.23e-35	127.0	290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,2VZ0V@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_551853_1	1101188.KI912155_gene2740	0.000318	43.1	COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,1W7I7@1268|Micrococcaceae	201174|Actinobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_551860_1	392499.Swit_4007	1.64e-63	211.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria,2KCWT@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type protease lipase transport system, ATPase and permease	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_551865_1	1095769.CAHF01000022_gene355	1.65e-66	204.0	COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,2VTFT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
k59_805025_1	1266925.JHVX01000005_gene1861	1.76e-142	431.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,371QF@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1036241_1	1163617.SCD_n00100	2.58e-110	336.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_551900_1	316055.RPE_3823	5.77e-55	182.0	COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,3JTG7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_06725	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
k59_551900_2	1280944.HY17_10010	7.44e-11	62.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,43ZC5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	MA20_06720	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_292602_1	1356854.N007_20665	7.29e-08	55.8	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,27A1K@186823|Alicyclobacillaceae	91061|Bacilli	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_292620_1	1435356.Y013_18500	4.99e-05	47.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4FVWN@85025|Nocardiaceae	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_292620_2	1265505.ATUG01000001_gene3942	0.000216	46.2	COG0664@1|root,COG1033@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales	28221|Deltaproteobacteria	K	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	GGDEF,LolA_like,MMPL,cNMP_binding
k59_551935_1	330214.NIDE3295	2.58e-32	122.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	ccoP	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrom_C,Cytochrome_CBB3,FixO
k59_551935_2	330214.NIDE3294	1.03e-41	146.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_805147_1	56780.SYN_00551	2.34e-41	155.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MQ74@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Penicillin-binding protein, dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
k59_292725_1	436308.Nmar_0222	1.85e-15	73.6	COG1402@1|root,arCOG04536@2157|Archaea,41SNC@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_292725_2	1229909.NSED_00930	1.1e-44	145.0	COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
k59_805172_1	436308.Nmar_1589	1.34e-06	46.6	arCOG10591@1|root,arCOG10591@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_805174_1	1038866.KB902773_gene863	3.3e-50	182.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_805175_1	1125863.JAFN01000001_gene1862	1.39e-96	288.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKFV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033,ko:K12369,ko:K13890	ko02010,ko02024,map02010,map02024	M00239,M00324,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	BPD_transp_1
k59_292746_1	246196.MSMEI_3140	8.61e-28	117.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,2359B@1762|Mycobacteriaceae	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LGT
k59_292755_1	945713.IALB_0661	1.15e-120	365.0	COG0855@1|root,COG0855@2|Bacteria	2|Bacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_1036402_1	1500281.JQKZ01000010_gene2380	1.16e-24	99.8	COG0605@1|root,COG0605@2|Bacteria,4NDZ4@976|Bacteroidetes,1HX6F@117743|Flavobacteriia,3ZQBI@59732|Chryseobacterium	976|Bacteroidetes	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_1036402_2	1519464.HY22_04770	3.23e-38	130.0	COG0316@1|root,COG0316@2|Bacteria,1FF80@1090|Chlorobi	1090|Chlorobi	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_292821_1	381666.PHG394	6.27e-22	99.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2VH1R@28216|Betaproteobacteria,1K2BQ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	menC	-	4.2.1.113,5.5.1.1	ko:K01856,ko:K02549	ko00130,ko00361,ko00362,ko00364,ko00623,ko01100,ko01110,ko01120,ko01220,map00130,map00361,map00362,map00364,map00623,map01100,map01110,map01120,map01220	M00116,M00568	R04031,R05300,R05390,R06989,R08116,R09229	RC00903,RC01038,RC01053,RC01108,RC01321,RC01356	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_805261_1	313628.LNTAR_03884	4.58e-78	251.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_292849_1	497964.CfE428DRAFT_0986	2.17e-69	228.0	COG0173@1|root,COG0173@2|Bacteria,46S7W@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_552147_1	1294143.H681_20610	3.17e-94	290.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_292884_1	330214.NIDE3046	2.31e-82	266.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1036494_1	1128421.JAGA01000002_gene232	9.02e-33	130.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_1036497_1	330214.NIDE0611	1.17e-42	150.0	COG1894@1|root,COG1894@2|Bacteria,3J0WX@40117|Nitrospirae	40117|Nitrospirae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1036497_2	330214.NIDE0612	1.82e-66	205.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	nuoE	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
k59_805401_1	1121403.AUCV01000001_gene700	5.28e-78	244.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2WJA1@28221|Deltaproteobacteria,2MJ9S@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfk-1	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_292991_1	1380394.JADL01000001_gene2940	1.22e-45	152.0	COG0066@1|root,COG0066@2|Bacteria,1RBRQ@1224|Proteobacteria,2UA0M@28211|Alphaproteobacteria,2JXDY@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the LeuD family	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_292991_2	1380394.JADL01000001_gene2941	5.4e-45	157.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TT8I@28211|Alphaproteobacteria,2JV7M@204441|Rhodospirillales	204441|Rhodospirillales	E	Aconitase family (aconitate hydratase)	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase
k59_805423_1	945713.IALB_2662	3.06e-104	328.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT,PMT_2,TPR_19
k59_1036557_1	545695.TREAZ_0100	9.37e-103	315.0	COG1155@1|root,COG1155@2|Bacteria,2J59J@203691|Spirochaetes	203691|Spirochaetes	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_805476_1	1191523.MROS_1571	5.67e-99	298.0	COG5557@1|root,COG5557@2|Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	hybB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	iAPECO1_1312.APECO1_3427,iE2348C_1286.E2348C_3282,iECABU_c1320.ECABU_c34010,iECOK1_1307.ECOK1_3414,iECS88_1305.ECS88_3377,iUMN146_1321.UM146_01380,iUTI89_1310.UTI89_C3417	NrfD
k59_552354_1	266779.Meso_1048	4.86e-10	59.7	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,43MVA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	PrpF protein	-	-	-	ko:K09788	ko00640,map00640	-	R11264	RC03405	ko00000,ko00001,ko01000	-	-	-	PrpF
k59_552354_2	243090.RB5963	2.85e-35	130.0	COG0758@1|root,COG0758@2|Bacteria,2J0ND@203682|Planctomycetes	203682|Planctomycetes	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
k59_552363_1	94624.Bpet4326	2.29e-33	126.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,3T1HR@506|Alcaligenaceae	28216|Betaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_552363_2	395494.Galf_2704	3.26e-87	268.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,2VK0H@28216|Betaproteobacteria,44V5D@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Cytochrome C assembly protein	ypjD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_552368_1	383372.Rcas_1819	1.15e-63	201.0	COG0491@1|root,COG0491@2|Bacteria,2G6X9@200795|Chloroflexi,3777M@32061|Chloroflexia	32061|Chloroflexia	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1036656_1	323848.Nmul_A0085	2.69e-65	208.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,372DG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Branched-chain amino acid ATP-binding cassette transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_1036661_1	1230476.C207_07035	7.7e-87	280.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,3JU9H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_805608_1	448385.sce6983	9.53e-51	171.0	COG3209@1|root,COG3385@1|root,COG3209@2|Bacteria,COG3385@2|Bacteria,1R55Y@1224|Proteobacteria,437YG@68525|delta/epsilon subdivisions,2X38D@28221|Deltaproteobacteria,2YUTS@29|Myxococcales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_552458_1	243233.MCA1526	4.57e-34	126.0	COG1721@1|root,COG1721@2|Bacteria,1R69F@1224|Proteobacteria,1S8QT@1236|Gammaproteobacteria,1XEZS@135618|Methylococcales	135618|Methylococcales	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_552458_2	314607.KB13_514	1.93e-13	69.7	COG0714@1|root,COG0714@2|Bacteria,1MUCP@1224|Proteobacteria,2VN99@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	-	-	-	-	-	-	-	-	-	AAA_3
k59_552538_1	391625.PPSIR1_40370	4.29e-121	360.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2Z30M@29|Myxococcales	28221|Deltaproteobacteria	L	COG3344 Retron-type reverse transcriptase	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_552541_2	670292.JH26_12705	6.48e-33	127.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_23605	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_805708_2	1031711.RSPO_c01374	8.15e-35	124.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,1K15D@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_552571_1	1713.JOFV01000002_gene709	4.2e-40	147.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	CAP,Laminin_G_3
k59_805744_1	1163617.SCD_n01759	4.87e-33	119.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,2VRE4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM AMMECR1 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
k59_805744_2	1192124.LIG30_4202	2.48e-32	120.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2VINV@28216|Betaproteobacteria,1KB7K@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_805745_1	227377.CBU_0242	6.83e-34	117.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1JEQJ@118969|Legionellales	118969|Legionellales	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_805745_2	247639.MGP2080_06472	4.67e-40	135.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_293421_1	37919.EP51_00470	1.19e-10	67.8	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4FUSX@85025|Nocardiaceae	201174|Actinobacteria	J	Amidase	zhuL	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_805797_1	945713.IALB_2412	1.13e-130	384.0	COG0076@1|root,COG0076@2|Bacteria	2|Bacteria	E	glutamate decarboxylase activity	ddc	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_552639_1	580332.Slit_2411	2.77e-17	77.8	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,2VTYC@28216|Betaproteobacteria,44VZ8@713636|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM DNA polymerase III chi subunit HolC	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_552639_2	557598.LHK_01414	4.85e-80	252.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,2KQ8S@206351|Neisseriales	206351|Neisseriales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_552645_1	436308.Nmar_0618	2.62e-88	282.0	COG3889@1|root,arCOG01672@2157|Archaea,41SA5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_805868_1	864051.BurJ1DRAFT_4462	2.49e-129	370.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,1KK3M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_805874_1	1121405.dsmv_3244	2.04e-74	238.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,2MINV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_293528_1	568706.BN118_1473	1.18e-79	246.0	COG0045@1|root,COG0045@2|Bacteria,1NG2I@1224|Proteobacteria	1224|Proteobacteria	C	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5
k59_805892_1	926569.ANT_19820	1.02e-63	209.0	COG0457@1|root,COG0457@2|Bacteria,2G8PU@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2
k59_805908_1	1191523.MROS_1977	5.75e-36	142.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	korA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1036932_1	749222.Nitsa_0955	7.19e-37	140.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2YNK2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_293635_1	1396141.BATP01000045_gene1848	1.88e-73	247.0	COG2911@1|root,COG3866@1|root,COG4932@1|root,COG5267@1|root,COG2911@2|Bacteria,COG3866@2|Bacteria,COG4932@2|Bacteria,COG5267@2|Bacteria,46TJE@74201|Verrucomicrobia,2IVHT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
k59_552816_1	1254432.SCE1572_51240	6.75e-21	86.3	COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,2YV1R@29|Myxococcales	28221|Deltaproteobacteria	F	deaminase	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
k59_552816_2	670487.Ocepr_0162	3.54e-20	90.5	COG0220@1|root,COG0220@2|Bacteria,1WI0J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_552827_1	497964.CfE428DRAFT_6228	2.38e-37	144.0	COG4191@1|root,COG4191@2|Bacteria,46TV0@74201|Verrucomicrobia	2|Bacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_9,Response_reg
k59_806026_1	519989.ECTPHS_00600	4.85e-05	49.3	COG0642@1|root,COG2202@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1X2SE@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
k59_66211_3	1283076.M1ICX5_9CAUD	4.65e-17	78.2	4QE3P@10239|Viruses,4QX79@35237|dsDNA viruses  no RNA stage,4QSZ8@28883|Caudovirales,4QK0B@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_66211_6	445696.E3ST24_9CAUD	2.47e-69	226.0	4QBSJ@10239|Viruses,4QUQN@35237|dsDNA viruses  no RNA stage,4QPFJ@28883|Caudovirales,4QIA7@10662|Myoviridae	10662|Myoviridae	S	DNA primase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_66211_7	1121028.ARQE01000006_gene4529	1.19e-64	207.0	COG1351@1|root,COG1351@2|Bacteria	2|Bacteria	F	thymidylate synthase (FAD) activity	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	HNH,Intein_splicing,Thy1
k59_629068_1	1040989.AWZU01000028_gene3007	1.63e-67	223.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,3JR67@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_758041_1	663610.JQKO01000018_gene2987	4.83e-41	156.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3N9YH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Heavy-metal-associated domain	actP	-	3.6.3.54	ko:K17686,ko:K19597	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5,3.A.3.5.20	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_270036_1	933262.AXAM01000005_gene2508	9.2e-13	70.1	COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,42NBF@68525|delta/epsilon subdivisions,2WNW9@28221|Deltaproteobacteria,2MHZE@213118|Desulfobacterales	28221|Deltaproteobacteria	N	PFAM SRP54-type protein, GTPase domain	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
k59_270036_2	933262.AXAM01000005_gene2509	2.13e-22	97.8	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,42NB2@68525|delta/epsilon subdivisions,2WIWG@28221|Deltaproteobacteria,2MI0U@213118|Desulfobacterales	28221|Deltaproteobacteria	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
k59_498929_1	1220535.IMCC14465_17250	1.5e-127	373.0	COG2159@1|root,COG2159@2|Bacteria,1R3TG@1224|Proteobacteria,2URNF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_498929_2	1150399.AQYK01000001_gene474	8.89e-13	69.3	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4FM14@85023|Microbacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_367674_1	27923.ML042713a-PA	1.12e-05	53.1	KOG2177@1|root,KOG2177@2759|Eukaryota,38F95@33154|Opisthokonta,3BA7J@33208|Metazoa	2759|Eukaryota	O	miRNA binding	-	-	-	ko:K02599,ko:K11997	ko01522,ko04320,ko04330,ko04658,ko04919,ko05020,ko05165,ko05200,ko05206,ko05224,map01522,map04320,map04330,map04658,map04919,map05020,map05165,map05200,map05206,map05224	M00682	-	-	ko00000,ko00001,ko00002,ko04121	-	-	-	Bromodomain,NHL,SAND
k59_204609_1	13037.EHJ65891	4.44e-23	95.5	COG1335@1|root,KOG4044@2759|Eukaryota,38EAH@33154|Opisthokonta,3BAPT@33208|Metazoa,3CSH5@33213|Bilateria,41ZG2@6656|Arthropoda,3SMVN@50557|Insecta,4460S@7088|Lepidoptera	33208|Metazoa	Q	Isochorismatase family	ISOC1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_825412_1	159450.NH14_28870	2.08e-64	219.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1K37E@119060|Burkholderiaceae	28216|Betaproteobacteria	C	oxidoreductase	porG	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_662177_1	96561.Dole_0059	1.08e-59	197.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2WJU8@28221|Deltaproteobacteria,2MIPX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_786378_1	42099.EPrPV00000017400	1.87e-36	141.0	COG2159@1|root,KOG4245@2759|Eukaryota,1MEGE@121069|Pythiales	121069|Pythiales	S	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1016107_1	261292.Nit79A3_1222	1.07e-53	180.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,372CZ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1016107_2	1288494.EBAPG3_5490	9.32e-56	177.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2VSD7@28216|Betaproteobacteria,373A1@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_1016107_3	228410.NE0609	1.93e-170	488.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2VKQB@28216|Betaproteobacteria,3720Y@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_758056_1	1163617.SCD_n01742	5.28e-65	220.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria	28216|Betaproteobacteria	D	FtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_596594_1	926550.CLDAP_39080	1.4e-45	165.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_987869_1	580340.Tlie_0939	3.19e-47	168.0	COG2801@1|root,COG2801@2|Bacteria,3TAWD@508458|Synergistetes	508458|Synergistetes	L	SPTR Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,rve
k59_694874_1	864051.BurJ1DRAFT_1999	2.6e-66	219.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KJ0P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K02021,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_270062_1	1288494.EBAPG3_3870	1.12e-61	196.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,371Y8@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_41487_1	404589.Anae109_0564	1.6e-118	353.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria	1224|Proteobacteria	H	Methyl-transferase	egtB	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
k59_74475_1	1340493.JNIF01000003_gene3305	7.71e-35	125.0	COG1878@1|root,COG1878@2|Bacteria	2|Bacteria	S	arylformamidase activity	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
k59_74475_2	246197.MXAN_6169	3.35e-28	110.0	COG1063@1|root,COG1063@2|Bacteria,1NXSN@1224|Proteobacteria,438FZ@68525|delta/epsilon subdivisions,2X3QX@28221|Deltaproteobacteria,2YWVR@29|Myxococcales	28221|Deltaproteobacteria	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
k59_1016110_2	401053.AciPR4_3150	9.22e-51	165.0	COG0105@1|root,COG0105@2|Bacteria,3Y4MW@57723|Acidobacteria,2JJD4@204432|Acidobacteriia	204432|Acidobacteriia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_694878_1	1454004.AW11_03673	2.72e-49	166.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,1KQRT@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_758057_2	765913.ThidrDRAFT_4544	3.5e-117	340.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1S900@1236|Gammaproteobacteria,1WZQJ@135613|Chromatiales	135613|Chromatiales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_758057_3	765914.ThisiDRAFT_2787	5.58e-24	96.7	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k59_923356_2	1227349.C170_04533	7.43e-19	86.7	COG2040@1|root,COG2040@2|Bacteria,1UHQ5@1239|Firmicutes,4HAS6@91061|Bacilli,26TIZ@186822|Paenibacillaceae	91061|Bacilli	E	Homocysteine S-methyltransferase	mmuM	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
k59_596605_1	1535287.JP74_00010	4.72e-65	207.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TTXX@28211|Alphaproteobacteria,3N7YJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	gltI	-	-	ko:K02030,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_498964_1	1286631.X805_15690	8.06e-99	313.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1KK82@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_727355_1	290317.Cpha266_1840	2.25e-95	311.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria	2|Bacteria	O	protein N-acetylglucosaminyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
k59_564143_1	1229909.NSED_08720	6.43e-22	87.8	arCOG10596@1|root,arCOG10596@2157|Archaea,41T8F@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_564143_2	1229909.NSED_08715	5.65e-93	275.0	COG3945@1|root,arCOG01471@2157|Archaea,41T3D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Hemerythrin HHE cation binding	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_987881_1	511062.GU3_05010	1.47e-130	387.0	COG3639@1|root,COG3639@2|Bacteria,1N3HU@1224|Proteobacteria,1RYH5@1236|Gammaproteobacteria,1Y4XC@135624|Aeromonadales	135624|Aeromonadales	P	COG3639 ABC-type phosphate phosphonate transport system permease component	phnE	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_955801_1	1288494.EBAPG3_22410	6.39e-53	171.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2VSRT@28216|Betaproteobacteria,37338@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_694894_1	575540.Isop_3045	2.51e-30	114.0	COG0457@1|root,COG0457@2|Bacteria,2IZQ0@203682|Planctomycetes	203682|Planctomycetes	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_106954_1	2055.JNXA01000012_gene2960	2.46e-83	265.0	COG4670@1|root,COG4670@2|Bacteria	2|Bacteria	I	ketone body catabolic process	-	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008410,GO:0008775,GO:0009987,GO:0016043,GO:0016740,GO:0016782,GO:0019752,GO:0022607,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_857429_1	1380394.JADL01000021_gene1881	5.51e-79	241.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_498972_1	876269.ARWA01000001_gene1346	3.65e-81	258.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,3N9RG@45404|Beijerinckiaceae	28211|Alphaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_662213_1	331869.BAL199_06164	2.29e-103	316.0	COG0477@1|root,COG2814@2|Bacteria,1MUDA@1224|Proteobacteria,2TS0P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1016121_1	1120705.FG95_03289	1.6e-56	192.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,2K117@204457|Sphingomonadales	204457|Sphingomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_825463_2	298386.PBPRA2893	5.55e-21	93.2	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1XSFX@135623|Vibrionales	135623|Vibrionales	M	Belongs to the peptidase S11 family	dacA	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_955819_1	930169.B5T_02488	1.86e-42	157.0	KOG2232@1|root,2Z84X@2|Bacteria,1MU34@1224|Proteobacteria,1SKC9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	3.5.1.23	ko:K12349	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00099	R01494	RC00064,RC00328	ko00000,ko00001,ko00002,ko01000	-	-	-	Ceramidase_alk
k59_367740_2	330214.NIDE4150	2.29e-15	77.0	COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
k59_41525_1	864051.BurJ1DRAFT_1346	2.13e-95	290.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,1KJXY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_955820_1	1206720.BAFQ01000118_gene2946	1.05e-15	74.7	COG1011@1|root,COG1011@2|Bacteria,2HHHH@201174|Actinobacteria,4G0G6@85025|Nocardiaceae	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	dehII	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
k59_955820_2	75379.Tint_2355	4.29e-73	227.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,1KJMH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_889631_1	1121440.AUMA01000006_gene1503	2.68e-07	58.2	COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WJ9C@28221|Deltaproteobacteria,2M9NJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	ET	extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_596628_1	1121405.dsmv_1005	6.98e-135	401.0	COG2766@1|root,COG2766@2|Bacteria,1PXNG@1224|Proteobacteria,42N5G@68525|delta/epsilon subdivisions,2WINM@28221|Deltaproteobacteria,2MINW@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Serine protein kinase	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_204665_1	472759.Nhal_1635	3.51e-99	313.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria,1WXPA@135613|Chromatiales	135613|Chromatiales	I	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2,SNARE_assoc
k59_270109_1	1229909.NSED_08255	1.1e-72	220.0	arCOG08676@1|root,arCOG08676@2157|Archaea,41SCF@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Archaeal ammonia monooxygenase subunit A (AmoA)	-	-	1.14.18.3,1.14.99.39	ko:K10944	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Archaeal_AmoA
k59_498998_1	580332.Slit_1712	7.07e-111	328.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VR2T@28216|Betaproteobacteria	28216|Betaproteobacteria	H	PUA-like domain	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PK,PUA_2
k59_367747_1	1121127.JAFA01000009_gene6892	3.38e-49	172.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2VMJ9@28216|Betaproteobacteria,1K26K@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_106982_1	330214.NIDE0516	2.64e-22	99.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	hcf136	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
k59_825478_1	1487953.JMKF01000004_gene680	1.3e-26	112.0	COG2931@1|root,COG2931@2|Bacteria,1G02E@1117|Cyanobacteria,1H9TQ@1150|Oscillatoriales	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind
k59_955828_1	1313304.CALK_0442	8.7e-20	91.3	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_987917_1	305700.B447_12337	1.8e-45	156.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,2KURX@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	cysB	-	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_987917_2	1288494.EBAPG3_13310	2.25e-39	144.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,371XE@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_464292_1	211586.SO_0365	1.78e-31	127.0	COG2807@1|root,COG2807@2|Bacteria,1NXQ2@1224|Proteobacteria,1RXXM@1236|Gammaproteobacteria,2QABM@267890|Shewanellaceae	1236|Gammaproteobacteria	P	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1016131_1	243233.MCA2493	7.06e-79	246.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1XDUU@135618|Methylococcales	135618|Methylococcales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_498999_1	945713.IALB_2663	5.13e-30	115.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_498999_2	945713.IALB_2662	4.69e-168	503.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT,PMT_2,TPR_19
k59_955841_1	522306.CAP2UW1_2865	1.33e-79	246.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,1KPN9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_987924_1	1163617.SCD_n00476	8.77e-81	249.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_663314_1	1129794.C427_1366	9.6e-78	266.0	COG0596@1|root,COG4206@1|root,COG0596@2|Bacteria,COG4206@2|Bacteria,1QVV2@1224|Proteobacteria,1T4JF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1016730_1	557598.LHK_01906	1.29e-170	491.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KPJ5@206351|Neisseriales	206351|Neisseriales	T	Sigma-54 interaction domain protein	glnG	-	-	ko:K07712,ko:K07714	ko02020,map02020	M00497,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_368815_1	1499683.CCFF01000017_gene2697	1.79e-40	153.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,36DJT@31979|Clostridiaceae	186801|Clostridia	M	stage V sporulation protein D	spoVD	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
k59_303184_1	1123393.KB891328_gene592	6.1e-168	484.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VNYV@28216|Betaproteobacteria,1KS6P@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_890709_1	1120746.CCNL01000008_gene781	2.16e-31	128.0	COG0145@1|root,COG0145@2|Bacteria,2NP17@2323|unclassified Bacteria	2|Bacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	hyuA	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_728535_1	864051.BurJ1DRAFT_0791	1.24e-102	317.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,2VKG8@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_140731_1	335543.Sfum_4045	8.55e-59	182.0	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,42SN5@68525|delta/epsilon subdivisions,2WP28@28221|Deltaproteobacteria,2MS1Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	DsrC like protein	dsrC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_140731_2	290315.Clim_0692	9.04e-05	44.7	COG1797@1|root,COG1797@2|Bacteria,1FEVE@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	-	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,GATase_3
k59_988971_2	745310.G432_01395	1.75e-51	177.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2K1MW@204457|Sphingomonadales	204457|Sphingomonadales	E	Acetylornithine deacetylase Succinyl-diaminopimelate	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_42685_1	1121930.AQXG01000001_gene1273	5.11e-64	221.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IP63@117747|Sphingobacteriia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	bepE_4	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_205755_1	420662.Mpe_A0704	1.22e-65	216.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,1KIUG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	DNA photolyase	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_597770_1	1280689.AUJC01000015_gene10	2.45e-44	161.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,36E52@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein TrkH	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_826637_1	329726.AM1_4593	1.58e-59	186.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_924537_1	859657.RPSI07_0950	1.3e-23	99.8	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,2VNV5@28216|Betaproteobacteria,1KH20@119060|Burkholderiaceae	28216|Betaproteobacteria	P	ABC-type glycine betaine transport system	opuBC	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
k59_924537_2	1532557.JL37_21140	1.58e-17	82.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,3T1Y4@506|Alcaligenaceae	28216|Betaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_924539_1	795666.MW7_0758	6.61e-67	221.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,1K50V@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
k59_243647_1	85643.Tmz1t_2648	7.15e-32	127.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_472042_2	96561.Dole_0851	1.96e-54	191.0	COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria,2MJ5S@213118|Desulfobacterales	28221|Deltaproteobacteria	G	alpha amylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,GDE_C,GDE_N
k59_310704_1	1238182.C882_4016	1.05e-18	83.6	COG3396@1|root,COG3396@2|Bacteria,1R8B1@1224|Proteobacteria,2U4FX@28211|Alphaproteobacteria,2JVQS@204441|Rhodospirillales	204441|Rhodospirillales	S	Phenylacetic acid catabolic protein	-	-	-	-	-	-	-	-	-	-	-	-	PaaA_PaaC
k59_18632_1	228410.NE0611	9.31e-168	475.0	COG0524@1|root,COG0524@2|Bacteria,1PDQE@1224|Proteobacteria,2VHMF@28216|Betaproteobacteria,372FP@32003|Nitrosomonadales	28216|Betaproteobacteria	H	pfkB family carbohydrate kinase	adoK	-	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100	-	R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_84030_1	522306.CAP2UW1_0634	7.18e-32	129.0	COG0642@1|root,COG0642@2|Bacteria,1R49A@1224|Proteobacteria,2VKU5@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_997064_1	984262.SGRA_2312	1.84e-38	142.0	COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,1IP5J@117747|Sphingobacteriia	976|Bacteroidetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_997064_2	517418.Ctha_1178	2.33e-47	169.0	COG0085@1|root,COG0085@2|Bacteria,1FDA5@1090|Chlorobi	1090|Chlorobi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_671804_1	1095769.CAHF01000014_gene2918	1.54e-107	330.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,4727V@75682|Oxalobacteraceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ilvG	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_472050_2	1231190.NA8A_10738	8.36e-22	88.2	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2UG8Q@28211|Alphaproteobacteria,43QQ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_344607_1	243231.GSU0004	5.06e-80	261.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,43T5S@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_441927_1	1229909.NSED_07830	3.19e-58	185.0	COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
k59_508399_1	936455.KI421499_gene6925	5.58e-70	226.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_23145	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_965526_1	1288494.EBAPG3_28130	4.26e-125	366.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,372QQ@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_243666_1	550540.Fbal_1164	1.42e-55	197.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_866644_1	1249627.D779_0385	2.58e-47	167.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1WXRW@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_866644_2	76114.ebA955	6.93e-32	119.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria,2KW2B@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_605930_1	1528106.JRJE01000005_gene1238	4.62e-49	160.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2U5CQ@28211|Alphaproteobacteria,2JSR1@204441|Rhodospirillales	204441|Rhodospirillales	I	COG2030 Acyl dehydratase	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016043,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0042620,GO:0042621,GO:0043933,GO:0044085,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
k59_605930_2	1123269.NX02_18090	2.97e-10	62.0	COG3128@1|root,COG3128@2|Bacteria,1MVVI@1224|Proteobacteria,2TRHC@28211|Alphaproteobacteria,2K3EK@204457|Sphingomonadales	204457|Sphingomonadales	O	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3,AhpC-TSA
k59_275530_2	518766.Rmar_1789	6.91e-31	119.0	COG0842@1|root,COG0842@2|Bacteria,4NWUF@976|Bacteroidetes,1FJ84@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_376704_1	1509405.GV67_08610	1.06e-46	164.0	COG0028@1|root,COG0028@2|Bacteria,1N4U6@1224|Proteobacteria,2U0I6@28211|Alphaproteobacteria,4BDDC@82115|Rhizobiaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_704663_1	232721.Ajs_3052	2.07e-13	69.3	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria,4ABAZ@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,IstB_IS21,rve
k59_704663_2	1123504.JQKD01000130_gene3194	4.67e-153	434.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VHN6@28216|Betaproteobacteria,4ACDX@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_765975_3	1262449.CP6013_3928	1.59e-05	49.7	COG3267@1|root,COG3267@2|Bacteria,1TRGM@1239|Firmicutes,24EPV@186801|Clostridia,36HUB@31979|Clostridiaceae	186801|Clostridia	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_18668_1	527002.yaldo0001_13240	5.74e-37	138.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,1RPPC@1236|Gammaproteobacteria,41E2P@629|Yersinia	1236|Gammaproteobacteria	P	extracellular solute-binding protein	afuA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_898454_1	1121937.AUHJ01000021_gene1432	1.69e-153	439.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,46BKC@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_866661_1	977880.RALTA_B0315	5.02e-26	108.0	COG2421@1|root,COG2421@2|Bacteria,1MXKY@1224|Proteobacteria,2VN9H@28216|Betaproteobacteria,1K3J2@119060|Burkholderiaceae	28216|Betaproteobacteria	C	formamidase	-	-	3.5.1.49	ko:K01455	ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200	-	R00524	RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
k59_18673_1	522306.CAP2UW1_1921	1.23e-112	342.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,1KQBB@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_441949_2	1266925.JHVX01000007_gene2386	4.76e-81	250.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,372M5@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_573721_1	450851.PHZ_p0187	1.74e-54	196.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2KJYY@204458|Caulobacterales	204458|Caulobacterales	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
k59_573721_2	2340.JV46_02630	1.06e-11	64.3	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1J64K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_508424_2	330214.NIDE1399	1.34e-28	107.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_704683_1	1469245.JFBG01000056_gene2455	6.67e-23	96.7	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1WVV8@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_704683_2	1131553.JIBI01000002_gene1782	1.68e-40	151.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,372K8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_149071_1	1121405.dsmv_1442	2.36e-102	327.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MI79@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_605958_1	1123367.C666_05000	4.41e-108	333.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2VM8J@28216|Betaproteobacteria,2KVNJ@206389|Rhodocyclales	206389|Rhodocyclales	C	nitrous oxide reductase	-	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
k59_866677_1	1417296.U879_08095	1.77e-67	213.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,2U4AQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_835219_1	485915.Dret_1750	2.57e-57	199.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
k59_704693_1	1163617.SCD_n02290	3.44e-38	144.0	COG3437@1|root,COG3829@1|root,COG4191@1|root,COG5001@1|root,COG3437@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg
k59_50835_1	1000565.METUNv1_00768	1.1e-74	247.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales	206389|Rhodocyclales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_966568_1	439235.Dalk_4766	4.16e-100	298.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,42PM3@68525|delta/epsilon subdivisions,2WKSN@28221|Deltaproteobacteria,2MI0X@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
k59_276037_1	457429.ABJI02000446_gene5398	6.29e-46	153.0	COG0748@1|root,COG0748@2|Bacteria,2I5IZ@201174|Actinobacteria	201174|Actinobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_276037_3	1123504.JQKD01000050_gene737	1.15e-185	531.0	COG1840@1|root,COG1840@2|Bacteria,1MWWI@1224|Proteobacteria,2VIG9@28216|Betaproteobacteria,4ABVV@80864|Comamonadaceae	28216|Betaproteobacteria	P	extracellular solute-binding protein, family 1	pgtC	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
k59_51763_1	710421.Mycch_2853	8.25e-44	157.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,232KS@1762|Mycobacteriaceae	201174|Actinobacteria	Q	cytochrome p450	cyp124A1	GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0009987,GO:0010430,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0019395,GO:0019752,GO:0020037,GO:0030258,GO:0031073,GO:0032787,GO:0034440,GO:0036094,GO:0036199,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044282,GO:0046164,GO:0046906,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070402,GO:0071704,GO:0097089,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652	1.14.15.14	ko:K20497	-	-	-	-	ko00000,ko00199,ko01000	-	-	-	p450
k59_933984_1	1502770.JQMG01000001_gene1014	9.29e-120	357.0	COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VMD2@28216|Betaproteobacteria,2KKBN@206350|Nitrosomonadales	206350|Nitrosomonadales	U	PFAM Sporulation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,SPOR
k59_705724_1	649831.L083_1694	1.3e-46	172.0	COG1404@1|root,COG3055@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria,2IF2T@201174|Actinobacteria,4DBYG@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Kelch_1,Peptidase_S8
k59_182518_2	56780.SYN_00867	1.56e-129	379.0	COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,42PX0@68525|delta/epsilon subdivisions,2WJUG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
k59_442925_1	1517681.HW45_27435	1.23e-37	141.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_150094_1	330214.NIDE0719	1.05e-64	207.0	28IX1@1|root,2Z8V3@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2914
k59_1021367_1	452637.Oter_4105	4.02e-74	227.0	COG2818@1|root,COG2818@2|Bacteria,46VJV@74201|Verrucomicrobia,3K9KD@414999|Opitutae	414999|Opitutae	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_345646_1	521011.Mpal_2625	3.24e-113	345.0	COG0685@1|root,arCOG04487@2157|Archaea,2XU03@28890|Euryarchaeota,2NAHD@224756|Methanomicrobia	224756|Methanomicrobia	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_574762_1	356829.BITS_0679	9.95e-42	152.0	COG1879@1|root,COG1879@2|Bacteria,2I2HU@201174|Actinobacteria,4CZS9@85004|Bifidobacteriales	201174|Actinobacteria	G	Periplasmic binding protein domain	rbsB	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
k59_472954_1	312153.Pnuc_0038	3.51e-29	113.0	COG1670@1|root,COG1670@2|Bacteria,1QVH4@1224|Proteobacteria,2VQSE@28216|Betaproteobacteria,1KG6J@119060|Burkholderiaceae	28216|Betaproteobacteria	J	N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_472954_2	1179778.PMM47T1_07391	0.000626	42.7	COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	(GGDEF) domain	pleD	-	2.7.7.65	ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
k59_639343_1	991905.SL003B_1045	1.06e-32	122.0	COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,2U255@28211|Alphaproteobacteria,4BSC8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_639343_2	479434.Sthe_1520	1.11e-19	86.7	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi,27XNT@189775|Thermomicrobia	189775|Thermomicrobia	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_311670_5	28072.Nos7524_1346	2.69e-06	60.8	COG2374@1|root,COG2931@1|root,COG3210@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	1.11.1.7,1.6.3.1	ko:K07004,ko:K13411,ko:K19511	ko04013,ko04624,map04013,map04624	-	-	-	ko00000,ko00001,ko01000,ko04131	5.B.1.2	-	-	An_peroxidase,Exo_endo_phos,HemolysinCabind,LTD,VCBS
k59_311670_6	1123508.JH636442_gene4405	1.52e-08	66.2	2DSR5@1|root,33H51@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_672927_1	305700.B447_19174	3.94e-25	103.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,2KUI2@206389|Rhodocyclales	206389|Rhodocyclales	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
k59_639349_1	887062.HGR_08269	3.97e-28	108.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2VJ8M@28216|Betaproteobacteria,4A9RP@80864|Comamonadaceae	28216|Betaproteobacteria	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Thioesterase
k59_639349_2	76114.ebB118	1.24e-55	176.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,2VTY1@28216|Betaproteobacteria,2KWNM@206389|Rhodocyclales	206389|Rhodocyclales	C	ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
k59_899436_1	1121033.AUCF01000045_gene3991	4.28e-97	291.0	COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,2TRR9@28211|Alphaproteobacteria,2JQCY@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
k59_867694_1	1123253.AUBD01000011_gene2078	4.87e-60	205.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RYFT@1236|Gammaproteobacteria,1X3IT@135614|Xanthomonadales	1236|Gammaproteobacteria	EU	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_117440_1	1459636.NTE_01618	5.97e-56	177.0	COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
k59_766930_1	1268622.AVS7_02523	1.91e-35	133.0	COG3181@1|root,COG3181@2|Bacteria,1R83F@1224|Proteobacteria,2VP0C@28216|Betaproteobacteria,4ABM9@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_639355_1	1283299.AUKG01000004_gene1206	2.71e-91	281.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CPPT@84995|Rubrobacteria	84995|Rubrobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_407880_1	330214.NIDE1510	1.45e-53	181.0	COG0750@1|root,COG0750@2|Bacteria,3J0GI@40117|Nitrospirae	40117|Nitrospirae	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
k59_345665_1	1304883.KI912532_gene1595	1.13e-37	145.0	COG3203@1|root,COG3203@2|Bacteria,1MWUN@1224|Proteobacteria,2VN8D@28216|Betaproteobacteria,2KUJ1@206389|Rhodocyclales	206389|Rhodocyclales	M	Outer membrane protein (Porin)	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
k59_533672_1	472759.Nhal_2944	2.42e-232	646.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1X0JE@135613|Chromatiales	135613|Chromatiales	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_117458_1	1121430.JMLG01000005_gene792	1.67e-25	110.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_941672_1	867903.ThesuDRAFT_01482	6.31e-61	205.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,3WCDR@538999|Clostridiales incertae sedis	186801|Clostridia	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_745895_2	543728.Vapar_6055	5.62e-45	152.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2VQ5D@28216|Betaproteobacteria,4ADG2@80864|Comamonadaceae	1224|Proteobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,YjgF_endoribonc
k59_773608_1	1328313.DS2_00935	3.35e-34	136.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,46634@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
k59_680694_1	1348657.M622_03005	2.58e-44	152.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2VKE7@28216|Betaproteobacteria,2KU7P@206389|Rhodocyclales	206389|Rhodocyclales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_680694_2	1163617.SCD_n01478	2.76e-88	270.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_844082_1	926569.ANT_19900	1.41e-70	225.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_384614_1	56780.SYN_01993	2.64e-40	147.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
k59_646723_1	436308.Nmar_0547	2.31e-48	166.0	COG0082@1|root,arCOG04133@2157|Archaea,41SC3@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_279980_2	1123354.AUDR01000011_gene1425	6.3e-74	236.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria	28216|Betaproteobacteria	I	carboxylase	accB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1005314_1	1000565.METUNv1_01451	4.49e-37	134.0	COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,2VMCD@28216|Betaproteobacteria,2KVCZ@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
k59_1005314_2	582744.Msip34_1501	2.04e-38	137.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2VJZS@28216|Betaproteobacteria,2KKPT@206350|Nitrosomonadales	206350|Nitrosomonadales	HJ	Belongs to the RimK family	-	-	-	-	-	-	-	-	-	-	-	-	RimK
k59_773615_1	945713.IALB_1448	1.07e-77	242.0	COG1559@1|root,COG1559@2|Bacteria	2|Bacteria	F	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_222037_1	497321.C664_11305	6.28e-110	332.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,2KUM9@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_1025176_2	358220.C380_06495	8.5e-87	265.0	COG0265@1|root,COG0265@2|Bacteria,1QWA4@1224|Proteobacteria,2VK6X@28216|Betaproteobacteria,4A9X2@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_906620_1	99598.Cal7507_5210	6.65e-43	150.0	COG1398@1|root,COG1398@2|Bacteria,1G100@1117|Cyanobacteria,1HJB1@1161|Nostocales	1117|Cyanobacteria	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_875048_1	977880.RALTA_A0383	4.22e-55	194.0	COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,1K40G@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD linked oxidase domain protein	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_157509_1	911239.CF149_02114	5.08e-55	188.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_974409_1	994479.GL877882_gene6819	1.78e-21	94.7	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4E4WS@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_279987_1	159450.NH14_05615	3.55e-99	310.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,1K1ZS@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_517192_1	370438.PTH_2624	6.02e-49	165.0	COG4662@1|root,COG4662@2|Bacteria,1TRK7@1239|Firmicutes,249VG@186801|Clostridia,260GI@186807|Peptococcaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
k59_941712_1	671143.DAMO_0056	3.8e-38	136.0	COG0341@1|root,COG0341@2|Bacteria,2NP4P@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_941712_2	330214.NIDE3287	2.16e-55	188.0	COG0342@1|root,COG0342@2|Bacteria,3J09Z@40117|Nitrospirae	40117|Nitrospirae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_745934_1	266117.Rxyl_0536	4.56e-74	246.0	COG2721@1|root,COG2721@2|Bacteria,2GJC8@201174|Actinobacteria	201174|Actinobacteria	G	D-galactarate dehydratase Altronate	-	-	4.2.1.42,4.2.1.7	ko:K01685,ko:K01708	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00631	R01540,R05608	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_353123_1	556269.ACDQ01000011_gene120	4.43e-47	171.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,472EV@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_517204_1	177437.HRM2_41920	3.27e-36	141.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42PTS@68525|delta/epsilon subdivisions,2WTHY@28221|Deltaproteobacteria,2MMXZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
k59_1025185_1	682795.AciX8_4389	1.25e-61	214.0	COG3696@1|root,COG3696@2|Bacteria,3Y3AQ@57723|Acidobacteria,2JKZY@204432|Acidobacteriia	204432|Acidobacteriia	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_942757_1	493475.GARC_0853	7.59e-24	105.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,465GI@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	styS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_8
k59_415280_1	316067.Geob_3517	1.39e-98	298.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,43T7M@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_28282_1	420662.Mpe_A2227	1.09e-152	442.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KNDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_125918_1	1255043.TVNIR_1173	3.63e-50	174.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1WXF3@135613|Chromatiales	135613|Chromatiales	I	Membrane protein involved in aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_125920_1	552398.HMPREF0866_02545	6.54e-10	55.8	COG0230@1|root,COG0230@2|Bacteria,1VK90@1239|Firmicutes,24UGN@186801|Clostridia,3WM8B@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
k59_385655_1	768671.ThimaDRAFT_2578	5.78e-07	52.8	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_385655_2	1288494.EBAPG3_13130	2.45e-24	96.3	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,3737W@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
k59_518306_1	1236902.ANAS01000004_gene3803	5.5e-39	143.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4EPFQ@85012|Streptosporangiales	201174|Actinobacteria	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_158565_1	1163617.SCD_n01668	1.13e-55	201.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_385656_2	330214.NIDE2826	9.68e-53	177.0	COG1459@1|root,COG1459@2|Bacteria,3J0HZ@40117|Nitrospirae	40117|Nitrospirae	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
k59_876118_1	330214.NIDE4383	1.53e-13	75.9	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_774542_1	521011.Mpal_0200	4.63e-14	75.9	COG0778@1|root,arCOG00288@2157|Archaea,2XXW2@28890|Euryarchaeota,2N9TG@224756|Methanomicrobia	224756|Methanomicrobia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_415302_1	1097668.BYI23_A011840	3.3e-27	104.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2VUF2@28216|Betaproteobacteria,1K7NX@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
k59_415302_2	1000565.METUNv1_02686	3.02e-09	57.4	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,2KVWI@206389|Rhodocyclales	206389|Rhodocyclales	BQ	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_319420_1	338963.Pcar_3003	9.79e-42	155.0	COG1538@1|root,COG1538@2|Bacteria,1MYXE@1224|Proteobacteria,42TA7@68525|delta/epsilon subdivisions,2WR7T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_907654_1	1348657.M622_08590	3.49e-77	238.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,2KV5S@206389|Rhodocyclales	206389|Rhodocyclales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_415306_1	323848.Nmul_A0536	2.23e-29	117.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,3721E@32003|Nitrosomonadales	28216|Betaproteobacteria	K	ribonuclease II	rnb	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
k59_942789_2	945713.IALB_3193	6.12e-119	347.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
k59_774553_1	713586.KB900536_gene538	6.16e-13	73.9	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWGD@135613|Chromatiales	135613|Chromatiales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1006356_1	443218.AS9A_4481	2.54e-22	97.1	COG3333@1|root,COG3333@2|Bacteria,2GJB2@201174|Actinobacteria,234KK@1762|Mycobacteriaceae	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_415315_1	404589.Anae109_0490	7.38e-32	122.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,42Z8C@68525|delta/epsilon subdivisions,2WU08@28221|Deltaproteobacteria,2YXJP@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_223126_1	1123504.JQKD01000002_gene3754	5.04e-60	200.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,4AD1S@80864|Comamonadaceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_280556_1	292415.Tbd_2694	4.8e-26	106.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,1KRCT@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_94007_1	573370.DMR_16160	4.52e-81	254.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42MRE@68525|delta/epsilon subdivisions,2WIP0@28221|Deltaproteobacteria,2M81I@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_280559_1	1121904.ARBP01000004_gene880	1.62e-44	154.0	COG1932@1|root,COG1932@2|Bacteria,4NE06@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1006379_1	1037409.BJ6T_83010	1.26e-116	338.0	COG3293@1|root,COG3293@2|Bacteria,1NCPP@1224|Proteobacteria	1224|Proteobacteria	L	Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3'	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_714612_1	1163617.SCD_n00990	5.86e-70	223.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VH8N@28216|Betaproteobacteria	28216|Betaproteobacteria	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
k59_385695_1	1217718.ALOU01000020_gene2167	4.48e-79	252.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,1K0Z0@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	bclA_2	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_28353_1	296591.Bpro_0953	3.54e-77	244.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,4AAXF@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_647833_1	1122176.KB903539_gene1370	2.96e-111	349.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes	976|Bacteroidetes	T	PFAM BNR Asp-box repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_354243_1	330214.NIDE1746	7.69e-17	84.7	COG4372@1|root,COG5343@1|root,COG4372@2|Bacteria,COG5343@2|Bacteria	2|Bacteria	S	Anti-sigma-K factor rskA	-	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	LZ_Tnp_IS66,RskA,zf-HC2
k59_1006408_1	330214.NIDE3338	5.76e-129	372.0	COG1131@1|root,COG1131@2|Bacteria,3J116@40117|Nitrospirae	40117|Nitrospirae	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_845301_1	1429916.X566_16150	2.03e-72	230.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2U6H0@28211|Alphaproteobacteria,3K62H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_845301_2	1054213.HMPREF9946_02503	2.61e-32	121.0	COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2TV0U@28211|Alphaproteobacteria,2JRPC@204441|Rhodospirillales	204441|Rhodospirillales	S	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
k59_774608_1	1121405.dsmv_3526	1.26e-71	223.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria,2MJ8F@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
k59_876190_1	945713.IALB_0590	1.19e-69	217.0	COG1825@1|root,COG1825@2|Bacteria	2|Bacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_5826_1	1121035.AUCH01000001_gene1900	5.23e-22	93.6	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VIX7@28216|Betaproteobacteria,2KU9Y@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_5826_2	697282.Mettu_1303	6.06e-09	57.8	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XEEP@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_658951_1	365046.Rta_34780	6.08e-47	162.0	COG3181@1|root,COG3181@2|Bacteria,1P88K@1224|Proteobacteria,2VJJP@28216|Betaproteobacteria,4AJD9@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_952525_1	1429916.X566_00580	5.57e-104	302.0	COG3335@1|root,COG3335@2|Bacteria,1RDBN@1224|Proteobacteria,2VFA9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	transposable element conserved	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_461828_1	991905.SL003B_4136	4.04e-163	464.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,4BT5R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_3
k59_691577_1	383372.Rcas_0893	7.39e-06	50.4	COG0607@1|root,COG0659@1|root,COG0607@2|Bacteria,COG0659@2|Bacteria,2G83D@200795|Chloroflexi,3764C@32061|Chloroflexia	32061|Chloroflexia	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	Rhodanese,STAS,Sulfate_transp
k59_691577_2	690850.Desaf_2173	5.5e-14	73.2	COG0730@1|root,COG0730@2|Bacteria,1Q05R@1224|Proteobacteria,42NT9@68525|delta/epsilon subdivisions,2WJVB@28221|Deltaproteobacteria,2M9C5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_886680_2	1122135.KB893157_gene170	1.65e-23	94.4	COG4392@1|root,COG4392@2|Bacteria,1NA6M@1224|Proteobacteria,2UICP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
k59_886680_3	42565.FP66_00405	1.84e-07	52.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1XI88@135619|Oceanospirillales	135619|Oceanospirillales	C	FAD-linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_169054_1	330214.NIDE4368	6.9e-129	378.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_136467_1	1453501.JELR01000005_gene1616	4.52e-56	194.0	COG3391@1|root,COG3391@2|Bacteria,1RA6R@1224|Proteobacteria,1SE8J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_5857_1	1042326.AZNV01000048_gene1240	6.54e-75	227.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2TS7U@28211|Alphaproteobacteria,4B70D@82115|Rhizobiaceae	28211|Alphaproteobacteria	JM	Glucose-1-phosphate cytidylyltransferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_5857_2	557598.LHK_02715	9.95e-12	64.7	COG0451@1|root,COG0451@2|Bacteria,1MV73@1224|Proteobacteria,2VI84@28216|Betaproteobacteria,2KQPB@206351|Neisseriales	206351|Neisseriales	M	Polysaccharide biosynthesis protein	rfbG	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_233460_1	1449065.JMLL01000010_gene1333	1.02e-07	51.6	COG3339@1|root,COG3339@2|Bacteria,1MZR5@1224|Proteobacteria,2UCIB@28211|Alphaproteobacteria,43KKN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1232)	MA20_25305	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_233460_2	991905.SL003B_0174	6.47e-55	181.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,4BPZE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	MA20_25320	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_103759_1	1229909.NSED_09155	8.48e-82	250.0	COG1701@1|root,arCOG04262@2157|Archaea,41SXP@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pfam:DUF137	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
k59_71307_1	857087.Metme_1146	1.47e-58	194.0	COG4782@1|root,COG4782@2|Bacteria,1MXVC@1224|Proteobacteria,1RYK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
k59_299217_1	1122947.FR7_4524	1.27e-06	54.7	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4H3PF@909932|Negativicutes	909932|Negativicutes	M	NlpC P60 family protein	lytE	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
k59_461850_1	945713.IALB_0556	1.49e-79	255.0	COG2804@1|root,COG2804@2|Bacteria	2|Bacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_626006_1	1459636.NTE_01413	9.52e-89	271.0	COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
k59_1014541_1	159450.NH14_05615	5.65e-115	352.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,1K1ZS@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_593479_1	1459636.NTE_00531	6.32e-42	148.0	COG1093@1|root,arCOG04107@2157|Archaea,41SHY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Translation initiation factor 2, alpha subunit	-	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
k59_984865_1	395495.Lcho_0491	1.66e-58	185.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2VR7B@28216|Betaproteobacteria,1KKXV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_984865_2	1163617.SCD_n00796	7.79e-09	56.6	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	peptidase m48, ste24p	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_952578_1	583345.Mmol_0339	3.05e-94	306.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,2KMFS@206350|Nitrosomonadales	206350|Nitrosomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_429919_1	1297570.MESS4_670035	1.29e-35	125.0	COG2149@1|root,COG2149@2|Bacteria,1N9QP@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF202
k59_429919_2	118166.JH976537_gene4085	4.05e-27	108.0	COG3119@1|root,COG3119@2|Bacteria,1G3EC@1117|Cyanobacteria,1H9S2@1150|Oscillatoriales	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_332226_1	748247.AZKH_0440	1.22e-22	91.7	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2VQGE@28216|Betaproteobacteria,2KW8Z@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
k59_332226_2	1266925.JHVX01000008_gene358	2.41e-92	282.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,371M0@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_233476_1	999541.bgla_1g17080	3.19e-159	472.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,1K06F@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_38474_1	880072.Desac_2816	5.84e-77	248.0	COG4770@1|root,COG5016@1|root,COG4770@2|Bacteria,COG5016@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	carboxylase	-	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_495819_1	395493.BegalDRAFT_0232	4.57e-70	225.0	COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria,461MK@72273|Thiotrichales	72273|Thiotrichales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_952588_1	93220.LV28_23390	2.97e-50	160.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSKY@28216|Betaproteobacteria,1K7RI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the HesB IscA family	iscA	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_952588_2	667632.KB890169_gene5008	2.58e-67	206.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ2I@28216|Betaproteobacteria,1K6Y7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_461868_1	319795.Dgeo_0844	4.98e-21	97.1	2DBFF@1|root,2Z8YA@2|Bacteria	2|Bacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
k59_103804_1	159087.Daro_3204	4.68e-95	290.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,2KUJT@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_299249_1	525897.Dbac_1216	3.08e-54	177.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42PNX@68525|delta/epsilon subdivisions,2WK8F@28221|Deltaproteobacteria,2M8X5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_691642_1	690850.Desaf_3656	2.65e-54	177.0	COG0765@1|root,COG0765@2|Bacteria,1QN80@1224|Proteobacteria,42NV7@68525|delta/epsilon subdivisions,2WKTD@28221|Deltaproteobacteria,2MAHR@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
k59_691642_2	926550.CLDAP_05450	8.23e-65	206.0	COG1126@1|root,COG1126@2|Bacteria,2G6SU@200795|Chloroflexi	200795|Chloroflexi	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k59_364659_1	502025.Hoch_1967	3.58e-57	187.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,42M0U@68525|delta/epsilon subdivisions,2WJR5@28221|Deltaproteobacteria,2Z0KD@29|Myxococcales	28221|Deltaproteobacteria	M	ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	LysM,MS_channel,TM_helix
k59_136520_1	266779.Meso_0801	9.99e-13	68.6	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,43GZZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EH	PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_136520_2	870187.Thini_4002	2.07e-27	108.0	COG1566@1|root,COG1566@2|Bacteria,1QUDS@1224|Proteobacteria,1T1V3@1236|Gammaproteobacteria,463WI@72273|Thiotrichales	72273|Thiotrichales	V	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_822248_1	945713.IALB_2927	5.85e-20	96.7	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CBM_6,DUF1565,PDZ_2,Trypsin_2
k59_626052_1	330214.NIDE0858	4.79e-91	272.0	COG0745@1|root,COG0745@2|Bacteria,3J0JU@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_364673_1	671143.DAMO_0565	1.01e-06	48.9	COG0522@1|root,COG0522@2|Bacteria,2NPCC@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_364673_2	671143.DAMO_0566	2.94e-66	211.0	COG0202@1|root,COG0202@2|Bacteria,2NNQQ@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_785416_1	314278.NB231_10293	1.01e-35	140.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1WW36@135613|Chromatiales	135613|Chromatiales	E	PFAM NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_136548_1	883081.HMPREF9698_01132	9.29e-16	82.0	COG1061@1|root,COG1061@2|Bacteria,1TQ62@1239|Firmicutes,4HAJ1@91061|Bacilli,27FV9@186828|Carnobacteriaceae	91061|Bacilli	L	Domain of unknown function (DUF3427)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,PLDc_2,ResIII
k59_136549_1	1408423.JHYA01000007_gene181	6.71e-41	150.0	COG0319@1|root,COG1159@1|root,COG0319@2|Bacteria,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H1WW@909932|Negativicutes	909932|Negativicutes	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_822280_1	1127673.GLIP_1552	6.59e-21	97.1	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,468K9@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8,Trans_reg_C
k59_169149_1	1030157.AFMP01000007_gene3160	3.4e-41	145.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,2K2FR@204457|Sphingomonadales	204457|Sphingomonadales	I	epoxide hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	EHN
k59_299286_1	946483.Cenrod_1830	9.99e-56	176.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2VR2S@28216|Betaproteobacteria,4ADW5@80864|Comamonadaceae	28216|Betaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_299286_2	1123228.AUIH01000003_gene834	1.09e-17	80.9	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1XHIU@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_626072_1	945713.IALB_0942	1.53e-16	80.1	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	pleD	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,GGDEF,Response_reg
k59_626072_2	318464.IO99_18070	1.46e-40	143.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,36EDR@31979|Clostridiaceae	186801|Clostridia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_38531_1	381666.H16_B1609	2.19e-31	123.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,1K2BP@119060|Burkholderiaceae	28216|Betaproteobacteria	MV	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_38531_2	998674.ATTE01000001_gene3680	1.42e-06	50.8	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,1RZ65@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	secreted hydrolase	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
k59_691682_1	1042377.AFPJ01000054_gene1686	3.23e-16	79.7	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,469KU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_691682_2	1249627.D779_4053	1.42e-31	117.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales	135613|Chromatiales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_626078_1	237368.SCABRO_03767	5.89e-82	254.0	COG1060@1|root,COG1060@2|Bacteria,2IX1I@203682|Planctomycetes	203682|Planctomycetes	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
k59_724198_1	1120965.AUBV01000001_gene3496	1.25e-19	86.3	COG1376@1|root,COG1376@2|Bacteria,4NNX7@976|Bacteroidetes,47NYB@768503|Cytophagia	976|Bacteroidetes	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD_2
k59_724198_2	908337.HMPREF9257_0827	2.86e-12	68.6	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,4HAIV@91061|Bacilli,27DEZ@186827|Aerococcaceae	91061|Bacilli	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_659076_1	1082705.JIBP01000003_gene2639	4.75e-14	73.9	COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,1RPQ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Flagellar Motor Protein	motB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009288,GO:0009425,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0071944,GO:0120100,GO:0120101	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
k59_659076_2	1122603.ATVI01000012_gene1081	4.7e-76	239.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,1RNTF@1236|Gammaproteobacteria,1X4NU@135614|Xanthomonadales	135614|Xanthomonadales	N	With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
k59_561077_1	1120971.AUCA01000006_gene2131	7.47e-21	94.4	COG3039@1|root,COG3039@2|Bacteria,1TRUS@1239|Firmicutes,4HCCQ@91061|Bacilli	91061|Bacilli	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF772
k59_495897_1	1121448.DGI_0184	3.64e-59	209.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M9AP@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_526919_1	1410620.SHLA_15c000610	2.15e-26	102.0	2BUCE@1|root,32PN5@2|Bacteria,1PS9E@1224|Proteobacteria,2V2YW@28211|Alphaproteobacteria,4BJVS@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_72650_1	2340.JV46_03560	4.51e-88	262.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1J8FE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_823552_1	1121091.AUMP01000031_gene1426	1.2e-27	106.0	COG3981@1|root,COG3981@2|Bacteria,1V1C4@1239|Firmicutes,4HG6C@91061|Bacilli	91061|Bacilli	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_921464_1	697282.Mettu_1556	4.71e-29	109.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S8WW@1236|Gammaproteobacteria,1XEZJ@135618|Methylococcales	135618|Methylococcales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_562329_1	1380394.JADL01000008_gene3735	6.38e-25	103.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,2JPX8@204441|Rhodospirillales	204441|Rhodospirillales	E	homoserine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
k59_562329_2	335659.S23_44300	6.19e-84	251.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,3JSMD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	MA20_26500	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_695445_1	1397528.Q671_07715	3.65e-87	269.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1XNI8@135619|Oceanospirillales	135619|Oceanospirillales	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_499505_1	118168.MC7420_1035	3.85e-34	135.0	COG0642@1|root,COG2202@1|root,COG3605@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3605@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H71H@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_172729_1	1116472.MGMO_3c00040	9.21e-101	304.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XFDE@135618|Methylococcales	135618|Methylococcales	L	PFAM RNA-directed DNA polymerase (reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_368246_1	331678.Cphamn1_2068	1.64e-80	252.0	COG0372@1|root,COG0372@2|Bacteria,1FD5Z@1090|Chlorobi	1090|Chlorobi	H	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_499511_1	323848.Nmul_A0337	2.32e-36	134.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,372IM@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_270598_1	484770.UFO1_2870	9.23e-42	154.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	60KD_IMP,PEP-utilizers,PPDK_N,Rhodanese,YceI
k59_433411_1	305700.B447_00660	4.35e-165	481.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,2KVS9@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type Fe3 transport system, permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_399602_1	1123023.JIAI01000002_gene4957	8e-31	120.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
k59_890124_1	1485545.JQLW01000005_gene926	2.63e-17	77.0	COG3118@1|root,COG3118@2|Bacteria,1QVD0@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the HupG HyaE family	hupG	-	-	ko:K03619	-	-	-	-	ko00000	-	-	-	HyaE
k59_890124_2	765910.MARPU_11450	1.85e-32	116.0	COG0298@1|root,COG0298@2|Bacteria,1N9Z3@1224|Proteobacteria,1SCWQ@1236|Gammaproteobacteria,1WZ92@135613|Chromatiales	135613|Chromatiales	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_236321_1	1238182.C882_2537	5.77e-106	323.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2TUPJ@28211|Alphaproteobacteria,2JRME@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_42074_1	323848.Nmul_A0787	1.13e-104	314.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,372DI@32003|Nitrosomonadales	28216|Betaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_75061_1	1229909.NSED_07450	1.35e-79	252.0	COG0475@1|root,arCOG01956@2157|Archaea	2157|Archaea	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Na_H_Exchanger
k59_923920_1	4113.PGSC0003DMT400011930	2.27e-32	129.0	COG1132@1|root,KOG0055@2759|Eukaryota,37HZ5@33090|Viridiplantae,3G9FQ@35493|Streptophyta,44QW4@71274|asterids	35493|Streptophyta	Q	ABC transporter	-	-	3.6.3.44	ko:K05658	ko02010,ko04976,ko05206,ko05226,map02010,map04976,map05206,map05226	-	-	-	ko00000,ko00001,ko01000,ko02000,ko04090,ko04147	3.A.1.201	-	-	ABC_membrane,ABC_tran
k59_205200_1	1283300.ATXB01000001_gene66	3.11e-75	247.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XF9A@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase SLT domain	-	-	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_172752_1	375286.mma_1078	4.33e-64	209.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,472E7@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Glutamine synthetase, catalytic domain	glnA	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360	5.4.4.3,6.3.1.2	ko:K01915,ko:K20712	ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253,R06988,R09284	RC00010,RC01754,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_399628_1	351627.Csac_1172	1.06e-05	52.4	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24XW6@186801|Clostridia,42F0S@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_335871_1	644282.Deba_1540	1.84e-36	139.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_172762_1	323848.Nmul_A1746	2.72e-43	146.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,371U7@32003|Nitrosomonadales	28216|Betaproteobacteria	K	RNA polymerase sigma factor	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_172762_2	765913.ThidrDRAFT_1359	8.78e-08	53.9	COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SGPC@1236|Gammaproteobacteria,1WYNC@135613|Chromatiales	135613|Chromatiales	T	PFAM Anti sigma-E protein RseA	-	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
k59_499541_1	406124.ACPC01000017_gene619	7.41e-07	50.1	COG0454@1|root,COG0456@2|Bacteria,1V50M@1239|Firmicutes,4HH63@91061|Bacilli,1ZG7D@1386|Bacillus	91061|Bacilli	K	acetyltransferase	yqjY	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
k59_499541_2	56780.SYN_02434	3.9e-166	470.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.5.1.106	ko:K15357	ko00760,ko01120,map00760,map01120	M00622	R09126	RC00323,RC02431	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_3,Abhydrolase_6,Hydrolase_4
k59_629683_1	1141662.OOA_14555	1.12e-96	308.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,3Z7RA@586|Providencia	1236|Gammaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_270636_1	405948.SACE_5073	8.23e-137	399.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4E9CU@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase	tnp3508a	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_695499_1	396588.Tgr7_2014	2.58e-93	284.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_727955_2	1454004.AW11_02855	1.01e-130	386.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2VPQP@28216|Betaproteobacteria	28216|Betaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_302665_1	330214.NIDE3370	1.41e-91	272.0	COG0491@1|root,COG0491@2|Bacteria,3J0VN@40117|Nitrospirae	40117|Nitrospirae	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_988449_1	861299.J421_1876	3.73e-93	288.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_236365_1	187272.Mlg_0956	1.6e-124	382.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_695511_1	335543.Sfum_2283	2.19e-81	251.0	COG4177@1|root,COG4177@2|Bacteria,1RD1T@1224|Proteobacteria,42SJY@68525|delta/epsilon subdivisions,2WPPK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_399654_1	1304883.KI912532_gene3161	1.66e-52	182.0	COG0664@1|root,COG0668@1|root,COG0664@2|Bacteria,COG0668@2|Bacteria,1R6J6@1224|Proteobacteria,2VPCU@28216|Betaproteobacteria,2KXC3@206389|Rhodocyclales	206389|Rhodocyclales	MT	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
k59_826070_1	472759.Nhal_1542	2.7e-39	136.0	2DN6U@1|root,32VVA@2|Bacteria,1N6AG@1224|Proteobacteria	1224|Proteobacteria	S	Cysteine rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_FGFR
k59_923982_1	1163617.SCD_n01045	2.48e-50	179.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,2VI9X@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_205252_1	1235457.C404_20175	1.42e-19	86.3	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,1K2PI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_205252_2	497321.C664_03440	2.93e-08	62.4	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2VIC1@28216|Betaproteobacteria,2KXAY@206389|Rhodocyclales	206389|Rhodocyclales	S	transport system, periplasmic component	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_890185_1	580332.Slit_1820	1.63e-55	194.0	COG3283@1|root,COG4191@1|root,COG4585@1|root,COG3283@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria,1PM1X@1224|Proteobacteria,2W8ZV@28216|Betaproteobacteria,44WJK@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
k59_499583_2	114615.BRADO0958	2.81e-05	46.6	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria,3JTGN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_18685	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_236383_1	926559.JoomaDRAFT_0554	3.13e-83	254.0	COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,1HX1P@117743|Flavobacteriia	976|Bacteroidetes	S	in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
k59_236383_2	1123057.P872_00620	5.56e-15	70.9	COG2259@1|root,COG2259@2|Bacteria,4NSBJ@976|Bacteroidetes,47R97@768503|Cytophagia	976|Bacteroidetes	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_727994_2	944481.JAFP01000001_gene423	1.72e-89	270.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2M734@213113|Desulfurellales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_597238_1	497321.C664_19670	5.78e-106	319.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,2KV17@206389|Rhodocyclales	206389|Rhodocyclales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_140219_1	861299.J421_1125	9.41e-121	353.0	COG0208@1|root,COG0208@2|Bacteria,1ZTAE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Fatty acid desaturase	-	-	1.14.19.11,1.14.19.2,1.14.19.26	ko:K03921	ko00061,ko01040,ko01212,map00061,map01040,map01212	-	R03370,R08161,R11108,R11109	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase_2
k59_988489_1	580332.Slit_0533	1.93e-139	419.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_236392_1	1163617.SCD_n02950	8.29e-51	177.0	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2VMDA@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Polysaccharide chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
k59_205268_1	313628.LNTAR_23894	6.23e-52	182.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1016460_1	979556.MTES_1206	4.44e-18	87.4	COG1175@1|root,COG1175@2|Bacteria,2GKBJ@201174|Actinobacteria,4FRAQ@85023|Microbacteriaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
k59_75145_1	118173.KB235914_gene250	0.000133	43.9	COG3677@1|root,COG3677@2|Bacteria	2|Bacteria	L	transposition, DNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_75145_2	1249627.D779_0358	4.27e-25	104.0	COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,1R7ZF@1224|Proteobacteria,1S6YQ@1236|Gammaproteobacteria,1WYGX@135613|Chromatiales	135613|Chromatiales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_597244_1	522306.CAP2UW1_1002	1.86e-92	285.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria	28216|Betaproteobacteria	CI	phosphate	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_270699_1	927658.AJUM01000034_gene181	3.98e-56	196.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,4NGSQ@976|Bacteroidetes,2FM60@200643|Bacteroidia,3XJR0@558415|Marinilabiliaceae	976|Bacteroidetes	GKT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppsA	-	-	-	-	-	-	-	-	-	-	-	PPDK_N,Response_reg
k59_368343_1	247634.GPB2148_3033	2.97e-38	135.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1J934@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_42168_1	935848.JAEN01000009_gene1518	1.57e-46	159.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,2PVIC@265|Paracoccus	28211|Alphaproteobacteria	E	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	ugpC	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264,GO:1901505	3.6.3.20	ko:K05816	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.3	-	-	ABC_tran,TOBE_2
k59_42168_2	987059.RBXJA2T_07025	1.09e-17	81.3	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2VICF@28216|Betaproteobacteria,1KMFN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	probably responsible for the translocation of the substrate across the membrane	ugpE	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
k59_302718_2	765912.Thimo_3383	4.92e-39	143.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1WW2W@135613|Chromatiales	135613|Chromatiales	P	PFAM sodium hydrogen exchanger	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_464830_1	644801.Psest_3427	2.87e-110	334.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria,1Z1TJ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_924015_1	631362.Thi970DRAFT_01084	1.21e-35	138.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales	135613|Chromatiales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_988507_1	204669.Acid345_4086	2.75e-79	246.0	COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria,2JMD3@204432|Acidobacteriia	204432|Acidobacteriia	H	Phosphofructokinase	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_988513_1	519989.ECTPHS_08948	1.18e-28	119.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WXB4@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,Response_reg
k59_368356_1	639283.Snov_1606	1.32e-112	333.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSBB@28211|Alphaproteobacteria,3EZ28@335928|Xanthobacteraceae	28211|Alphaproteobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
k59_528777_1	1125863.JAFN01000001_gene3241	1.06e-16	79.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_10,Fer4_8,Nitrate_red_gam
k59_108654_1	1459636.NTE_00589	1.98e-21	102.0	COG0726@1|root,arCOG09729@1|root,arCOG02876@2157|Archaea,arCOG09729@2157|Archaea,41T20@651137|Thaumarchaeota	2157|Archaea	G	xylanase chitin deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	CHB_HEX_C_1,HYR,Polysacc_deac_1
k59_859090_2	335283.Neut_0548	1.26e-30	122.0	COG3115@1|root,COG3115@2|Bacteria,1NJ6D@1224|Proteobacteria,2VHQ7@28216|Betaproteobacteria,372FG@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	-	-	-	-	-	-	-	-	-	ZipA_C
k59_400572_1	1146883.BLASA_5070	1.68e-12	64.7	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
k59_827197_1	1538295.JY96_17400	1.85e-15	68.9	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2VVW8@28216|Betaproteobacteria,1KMIZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_827197_2	265072.Mfla_0312	5.25e-43	140.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2VU1B@28216|Betaproteobacteria,2KN2K@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_827197_3	159087.Daro_3142	2.07e-89	268.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2VKTW@28216|Betaproteobacteria,2KUXZ@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_696677_1	1485544.JQKP01000004_gene565	2.69e-40	149.0	COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,44VIR@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_303713_1	697282.Mettu_3224	1.07e-20	92.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XE8Y@135618|Methylococcales	135618|Methylococcales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_303713_2	525903.Taci_1495	1.6e-25	97.8	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	23S_rRNA_IVP
k59_108658_1	1307437.J139_15006	0.000108	44.7	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,1RP0R@1236|Gammaproteobacteria,2Q02D@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	ampH	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_271630_1	713586.KB900536_gene1566	6.32e-14	70.5	COG1416@1|root,COG1416@2|Bacteria,1MYMK@1224|Proteobacteria,1SD2F@1236|Gammaproteobacteria,1X1AM@135613|Chromatiales	135613|Chromatiales	K	AntiSigma factor	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	-
k59_271630_2	317025.Tcr_2158	2.63e-33	120.0	COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,1S6P0@1236|Gammaproteobacteria,462TC@72273|Thiotrichales	72273|Thiotrichales	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_696687_1	330214.NIDE1528	2.67e-59	194.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,FHA,Yop-YscD_cpl
k59_696687_2	240015.ACP_1026	1.11e-23	99.4	COG0631@1|root,COG0631@2|Bacteria,3Y4SV@57723|Acidobacteria,2JJFU@204432|Acidobacteriia	204432|Acidobacteriia	T	Protein phosphatase 2C	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_175985_1	765912.Thimo_1266	5.23e-10	56.2	COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,1WZ4M@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0125 (RnfH) family	-	-	-	ko:K09801	-	-	-	-	ko00000	-	-	-	Ub-RnfH
k59_175985_2	522306.CAP2UW1_4388	6.27e-85	257.0	COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,2VJ7M@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_633935_2	483219.LILAB_20260	4.11e-42	150.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_788149_1	314278.NB231_16458	1.6e-60	210.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales	135613|Chromatiales	G	PFAM glycoside hydrolase, family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_732455_1	690850.Desaf_0477	1.79e-50	175.0	COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria,42YC9@68525|delta/epsilon subdivisions,2WTSH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_273366_1	83406.HDN1F_22510	3.74e-115	346.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1J4CY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_601556_1	436308.Nmar_1684	3.91e-134	394.0	arCOG08795@1|root,arCOG08795@2157|Archaea	2157|Archaea	C	copper ion binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_601556_2	1229909.NSED_08975	2.98e-25	99.8	arCOG10598@1|root,arCOG10598@2157|Archaea	2157|Archaea	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
k59_468408_1	1229909.NSED_03745	1.12e-26	103.0	COG2047@1|root,arCOG00348@2157|Archaea,41SFT@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
k59_960999_1	1279017.AQYJ01000029_gene4002	4.09e-33	132.0	COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria,465CI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	vgrG	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Gp5_C,Phage_GPD
k59_830582_1	1123367.C666_14340	9.53e-99	313.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
k59_992709_1	228410.NE0993	3.31e-80	249.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,3725K@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_862185_1	331869.BAL199_29635	2.89e-79	244.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,4BPAZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_372437_1	1038862.KB893823_gene12	1.23e-108	323.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria,3JTXJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_762206_1	991905.SL003B_1052	4.12e-28	112.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_762206_2	1144310.PMI07_005444	1.66e-44	154.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2U256@28211|Alphaproteobacteria,4BCRD@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.2.1.83	ko:K10220	ko00362,ko01120,map00362,map01120	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_111943_1	748247.AZKH_4287	2.05e-98	297.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria,2KVWV@206389|Rhodocyclales	206389|Rhodocyclales	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
k59_14239_1	349521.HCH_06817	1.91e-62	202.0	COG0524@1|root,COG0524@2|Bacteria,1QTMT@1224|Proteobacteria,1S1JQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
k59_14239_2	1177154.Y5S_00564	1.83e-10	60.8	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1XH8Q@135619|Oceanospirillales	135619|Oceanospirillales	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12,1.2.1.72	ko:K00134,ko:K03472	ko00010,ko00710,ko00750,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map00750,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00124,M00165,M00166,M00308,M00552	R01061,R01825	RC00149,RC00242	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_468425_1	1379698.RBG1_1C00001G0297	2.75e-32	126.0	COG4881@1|root,COG4881@2|Bacteria	2|Bacteria	-	-	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_273378_1	543728.Vapar_6249	1.39e-73	224.0	COG2010@1|root,COG2010@2|Bacteria,1RH1S@1224|Proteobacteria,2VQ9Y@28216|Betaproteobacteria,4AHIR@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_46521_1	342113.DM82_873	2.77e-35	124.0	COG3293@1|root,COG3293@2|Bacteria,1PE1I@1224|Proteobacteria,2VSHY@28216|Betaproteobacteria,1K7K9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_177188_1	113395.AXAI01000004_gene4529	8.03e-08	58.5	COG1309@1|root,COG1309@2|Bacteria,1R67Z@1224|Proteobacteria,2VF1G@28211|Alphaproteobacteria,3JUFF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_177188_2	706587.Desti_3799	2.83e-07	52.4	COG1566@1|root,COG1566@2|Bacteria,1QUDS@1224|Proteobacteria,42QZG@68525|delta/epsilon subdivisions,2WN4C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_79588_1	1151122.AQYD01000004_gene2601	1.44e-107	332.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
k59_762216_1	1125863.JAFN01000001_gene910	4.21e-107	323.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
k59_46529_1	945713.IALB_2254	1.45e-112	332.0	COG4864@1|root,COG4864@2|Bacteria	2|Bacteria	S	SigmaW regulon antibacterial	yqfA	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
k59_273387_1	2340.JV46_20880	2.82e-86	272.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1J5H2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iSFV_1184.SFV_1868	GAD,tRNA-synt_2,tRNA_anti-codon
k59_894376_1	323848.Nmul_A0900	3.38e-98	291.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2VPNZ@28216|Betaproteobacteria,372RS@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_894376_2	977880.RALTA_A2969	2.09e-25	97.1	COG3189@1|root,COG3189@2|Bacteria,1RHYB@1224|Proteobacteria,2VSIB@28216|Betaproteobacteria,1K7MI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
k59_928443_1	1384057.CD33_04875	6.62e-55	179.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4HABJ@91061|Bacilli,3IVNK@400634|Lysinibacillus	91061|Bacilli	E	amino acid ABC transporter ATPase	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_928443_2	644966.Tmar_1815	3.91e-10	60.5	COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1UR00@1239|Firmicutes,24FGE@186801|Clostridia	186801|Clostridia	P	branched-chain amino acid transport system, permease component	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_306755_1	1446473.JHWH01000003_gene3325	1.78e-07	52.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria,2PUMD@265|Paracoccus	28211|Alphaproteobacteria	CH	Catalyzes the formation of protocatechuate from 4-hydroxybenzoate	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
k59_306755_2	1110697.NCAST_08_00190	4.6e-07	58.2	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4FWMF@85025|Nocardiaceae	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_762226_1	204669.Acid345_2740	1.76e-56	192.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_601600_1	7091.BGIBMGA010512-TA	0.000308	45.8	COG1028@1|root,KOG0725@2759|Eukaryota,38BUC@33154|Opisthokonta,3BC34@33208|Metazoa,3D09G@33213|Bilateria,41XDM@6656|Arthropoda,3SIYY@50557|Insecta	33154|Opisthokonta	Q	Oxidoreductase activity. It is involved in the biological process described with metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_79609_1	1499967.BAYZ01000054_gene4816	6.32e-06	50.8	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_732519_1	395494.Galf_1842	7.74e-71	223.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,44VNR@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Inhibitor of apoptosis-promoting Bax1	-	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
k59_372472_1	158500.BV97_03308	3.37e-22	99.0	COG2267@1|root,COG2267@2|Bacteria,1MVDA@1224|Proteobacteria,2TUDQ@28211|Alphaproteobacteria,2K694@204457|Sphingomonadales	204457|Sphingomonadales	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
k59_830626_1	1282876.BAOK01000001_gene1722	5.22e-73	225.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2TRUT@28211|Alphaproteobacteria,4BQ4E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_177210_1	96561.Dole_0431	4.88e-77	244.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42MPR@68525|delta/epsilon subdivisions,2WNM3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Multicopper	cumA	-	-	ko:K04753	-	-	-	-	ko00000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_177210_2	335543.Sfum_1242	2.55e-58	184.0	2C1PD@1|root,326ZJ@2|Bacteria,1RHSG@1224|Proteobacteria,431SZ@68525|delta/epsilon subdivisions,2WW9U@28221|Deltaproteobacteria,2MS80@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_46541_1	323848.Nmul_A0580	1.39e-22	93.6	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,2VRHV@28216|Betaproteobacteria,3730Z@32003|Nitrosomonadales	28216|Betaproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_46541_2	1454004.AW11_00417	1.88e-20	85.5	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_46541_3	1485544.JQKP01000001_gene922	1.83e-223	629.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,44VGZ@713636|Nitrosomonadales	28216|Betaproteobacteria	J	PFAM RNA-binding protein AU-1 Ribonuclease E G	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_14272_1	1454004.AW11_04015	3.33e-99	323.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg
k59_961055_1	352165.HMPREF7215_2259	2.4e-12	68.6	COG0628@1|root,COG0628@2|Bacteria,3T9W6@508458|Synergistetes	508458|Synergistetes	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_372483_1	76114.ebA4973	5.3e-83	268.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,2KUM5@206389|Rhodocyclales	206389|Rhodocyclales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_14282_1	1385517.N800_08475	8.53e-39	142.0	COG3386@1|root,COG3386@2|Bacteria,1P3IB@1224|Proteobacteria	1224|Proteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
k59_992773_1	870187.Thini_4455	1.71e-37	137.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,462GE@72273|Thiotrichales	72273|Thiotrichales	U	MarC family integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
k59_992773_2	266264.Rmet_1067	4.51e-10	58.2	COG2518@1|root,COG2518@2|Bacteria,1QY0N@1224|Proteobacteria,2WH8G@28216|Betaproteobacteria,1KIIK@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
k59_240013_1	1123393.KB891327_gene253	4.17e-142	419.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,1KS41@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_992776_1	1031711.RSPO_c01063	1.34e-31	127.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2VHW1@28216|Betaproteobacteria,1K153@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM surface antigen (D15)	tama	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_928474_1	1029823.AFIE01000082_gene3490	2.12e-36	130.0	COG0454@1|root,COG0454@2|Bacteria,1N1AI@1224|Proteobacteria,1SEEH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
k59_928474_2	1206731.BAGB01000047_gene5175	4.18e-11	63.5	COG1028@1|root,COG1028@2|Bacteria,2GK47@201174|Actinobacteria,4FXVP@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	ydaD	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_894411_1	313606.M23134_06511	3.29e-10	65.9	COG2208@1|root,COG2208@2|Bacteria,4PMCM@976|Bacteroidetes,47MWQ@768503|Cytophagia	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	srrB	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CBS,HAMP,SpoIIE,TPR_12,TPR_8,Y_Y_Y,dCache_1
k59_634015_1	1123261.AXDW01000003_gene1982	6.84e-83	258.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,1RMY2@1236|Gammaproteobacteria,1XDBK@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_894417_1	861299.J421_1239	1.75e-28	109.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
k59_372502_1	56780.SYN_00180	2.87e-56	184.0	COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,42MNX@68525|delta/epsilon subdivisions,2WXBI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_437743_1	580332.Slit_0137	1.32e-85	264.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,44VN9@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_928491_1	1100721.ALKO01000018_gene1195	1.16e-22	96.7	COG2308@1|root,COG2308@2|Bacteria,1P9A0@1224|Proteobacteria,2VISX@28216|Betaproteobacteria,4AC8M@80864|Comamonadaceae	28216|Betaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1018839_2	1122214.AQWH01000014_gene3646	2.08e-39	136.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria,2PJQN@255475|Aurantimonadaceae	28211|Alphaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_830674_1	1442599.JAAN01000004_gene1056	6.12e-91	286.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales	135614|Xanthomonadales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_992792_1	1121861.KB899916_gene1772	5.48e-85	263.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_177246_1	448385.sce8130	2.45e-77	244.0	COG0520@1|root,COG0520@2|Bacteria,1MXH1@1224|Proteobacteria,43203@68525|delta/epsilon subdivisions,2WWMI@28221|Deltaproteobacteria,2YTY1@29|Myxococcales	28221|Deltaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	cefD	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_14310_1	344747.PM8797T_26025	1.15e-51	181.0	COG0129@1|root,COG0129@2|Bacteria,2J2MS@203682|Planctomycetes	203682|Planctomycetes	EG	Belongs to the IlvD Edd family	-	-	-	-	-	-	-	-	-	-	-	-	ILVD_EDD
k59_961093_1	1335757.SPICUR_00295	4.78e-121	359.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_209559_1	450380.JPSY01000004_gene3089	2.46e-10	62.4	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4FKJ5@85023|Microbacteriaceae	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_372513_2	1463841.JOIR01000008_gene3883	2.62e-05	50.4	COG3290@1|root,COG3290@2|Bacteria,2GIRZ@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction histidine kinase regulating citrate malate metabolism	-	-	2.7.13.3	ko:K02476	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,PAS,SPOB_a,sCache_3_2
k59_437749_1	706587.Desti_4999	6.13e-152	442.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42PXA@68525|delta/epsilon subdivisions,2WM6E@28221|Deltaproteobacteria,2MRCU@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_894429_1	76114.ebA7120	9.94e-103	308.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2VHF1@28216|Betaproteobacteria,2KV4C@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_840291_2	1040989.AWZU01000040_gene6011	2.53e-149	425.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTGR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1001754_1	439235.Dalk_3362	7.07e-87	269.0	COG0427@1|root,COG0427@2|Bacteria,1NVAY@1224|Proteobacteria,42ZS2@68525|delta/epsilon subdivisions,2WUYX@28221|Deltaproteobacteria,2MN92@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
k59_903086_1	28229.ND2E_0517	1.39e-24	94.4	COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,2Q78E@267889|Colwelliaceae	1236|Gammaproteobacteria	J	Global regulator protein family	csrA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005979,GO:0006109,GO:0006139,GO:0006417,GO:0006446,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010675,GO:0010677,GO:0010906,GO:0010962,GO:0016070,GO:0016071,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032881,GO:0032885,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0043255,GO:0043467,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045719,GO:0045912,GO:0045947,GO:0046483,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0062012,GO:0065007,GO:0070873,GO:0070874,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
k59_840293_1	323848.Nmul_A0003	2.02e-59	202.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3725J@32003|Nitrosomonadales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_840293_2	85643.Tmz1t_0002	3.96e-37	135.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,2KV12@206389|Rhodocyclales	206389|Rhodocyclales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_676945_1	243365.CV_1373	8.45e-39	141.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,2KQB1@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
k59_676945_2	76114.ebA4732	0.000271	43.5	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,2KVGG@206389|Rhodocyclales	206389|Rhodocyclales	S	synthesis repressor, PhaR	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
k59_55361_1	292415.Tbd_1717	2.36e-101	303.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VIX7@28216|Betaproteobacteria,1KRK8@119069|Hydrogenophilales	119069|Hydrogenophilales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_840295_1	795955.AFRW01000004_gene1492	5.59e-40	146.0	COG0477@1|root,COG0477@2|Bacteria,2GKVX@201174|Actinobacteria,1WCEN@1268|Micrococcaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_411218_1	1210884.HG799475_gene15209	1.83e-41	161.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_676951_1	748658.KB907313_gene2363	4.73e-53	189.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1X2AG@135613|Chromatiales	135613|Chromatiales	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc,PilZ
k59_903097_1	96561.Dole_0153	1.83e-54	189.0	28M0D@1|root,2ZAFE@2|Bacteria,1R6YH@1224|Proteobacteria,42NPF@68525|delta/epsilon subdivisions,2WM7K@28221|Deltaproteobacteria,2MIG7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
k59_381258_1	595460.RRSWK_02095	7.78e-105	320.0	COG4146@1|root,COG4146@2|Bacteria,2J29I@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_411220_1	330214.NIDE1026	1.43e-53	176.0	COG3901@1|root,COG3901@2|Bacteria	2|Bacteria	CK	FMN binding	nosR	-	-	ko:K19339,ko:K19343	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4_5
k59_903101_1	1283300.ATXB01000001_gene380	8.66e-25	107.0	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XE60@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_476246_1	640081.Dsui_1379	6.86e-46	156.0	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,2VSI4@28216|Betaproteobacteria,2KWMF@206389|Rhodocyclales	206389|Rhodocyclales	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
k59_476246_2	1444770.AF72_08490	6.86e-07	52.8	COG3117@1|root,COG3117@2|Bacteria,1NGCC@1224|Proteobacteria,1SGDP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA	lptC	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
k59_770377_1	1229909.NSED_01120	1.99e-159	466.0	COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the MCM family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
k59_121311_2	388051.AUFE01000001_gene2113	3.61e-17	79.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2VPKX@28216|Betaproteobacteria,1K0SW@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome c-type protein	napC	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
k59_446704_1	595537.Varpa_3005	2.78e-150	454.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_840311_1	76114.ebA1004	5.85e-64	210.0	COG0657@1|root,COG0657@2|Bacteria,1MV89@1224|Proteobacteria,2VJJC@28216|Betaproteobacteria,2M03F@206389|Rhodocyclales	206389|Rhodocyclales	I	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
k59_970661_1	709797.CSIRO_4207	2.22e-56	192.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,3JSB4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_742164_1	330214.NIDE0561	2.08e-16	77.8	COG0535@1|root,COG0535@2|Bacteria,3J10V@40117|Nitrospirae	40117|Nitrospirae	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_840314_2	388051.AUFE01000071_gene3846	1.6e-69	221.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1K39S@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the thiolase family	phbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_446706_1	330214.NIDE4110	2.25e-143	418.0	COG0119@1|root,COG0119@2|Bacteria,3J0DC@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_315150_1	266117.Rxyl_2991	6.66e-15	77.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,4CTXT@84995|Rubrobacteria	84995|Rubrobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_938019_1	395961.Cyan7425_1971	4.52e-43	148.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,3KHS0@43988|Cyanothece	1117|Cyanobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_871527_2	1298867.AUES01000038_gene820	2.01e-41	154.0	COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1MVWV@1224|Proteobacteria,2UNZ9@28211|Alphaproteobacteria,3K2C1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	PT	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp,cNMP_binding
k59_381272_1	290397.Adeh_0964	2.47e-84	262.0	COG1075@1|root,COG1075@2|Bacteria,1R88U@1224|Proteobacteria,4389A@68525|delta/epsilon subdivisions,2XA37@28221|Deltaproteobacteria,2YW9M@29|Myxococcales	28221|Deltaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
k59_840317_1	1442599.JAAN01000033_gene1668	4.76e-59	186.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1X6HP@135614|Xanthomonadales	135614|Xanthomonadales	KT	response regulator	pilG	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_840317_2	83406.HDN1F_36840	1.85e-35	124.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria,1J67D@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	cheY-homologous receiver domain	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_446712_1	1243664.CAVL020000045_gene2105	1.42e-106	322.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HA40@91061|Bacilli,1ZMF3@1386|Bacillus	91061|Bacilli	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
k59_23649_1	933262.AXAM01000002_gene554	9.67e-101	305.0	COG0745@1|root,COG0745@2|Bacteria,1NE8H@1224|Proteobacteria,42NEH@68525|delta/epsilon subdivisions,2WK1M@28221|Deltaproteobacteria,2MHU4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2,Response_reg
k59_742177_1	1206741.BAFX01000095_gene4531	2.18e-14	77.8	COG0477@1|root,COG0477@2|Bacteria,2GMEJ@201174|Actinobacteria,4FYE6@85025|Nocardiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_476265_1	1169143.KB911049_gene5579	6.58e-37	137.0	COG2207@1|root,COG2207@2|Bacteria,1MY46@1224|Proteobacteria,2W1XW@28216|Betaproteobacteria,1KFVM@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
k59_513481_1	1713.JOFV01000007_gene2974	3.9e-15	75.9	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4F0WX@85016|Cellulomonadaceae	201174|Actinobacteria	L	PFAM AAA ATPase central domain protein	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_513481_2	439235.Dalk_0492	4.22e-56	187.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2MIJC@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_871539_1	1121405.dsmv_2611	2.8e-45	165.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_186057_1	395961.Cyan7425_1386	6.82e-84	265.0	COG3540@1|root,COG3540@2|Bacteria,1G0C9@1117|Cyanobacteria,3KG8D@43988|Cyanothece	1117|Cyanobacteria	P	PhoD-like phosphatase, N-terminal domain	phoD	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
k59_1001811_1	557598.LHK_00268	1.46e-31	114.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2VQ4W@28216|Betaproteobacteria,2KQFH@206351|Neisseriales	206351|Neisseriales	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_1001811_2	270374.MELB17_20126	2.13e-30	111.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,4679B@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_903140_1	706587.Desti_2503	1.11e-87	282.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MRGT@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_55404_1	296587.XP_002499809.1	1.76e-59	208.0	2E3BA@1|root,2SAF2@2759|Eukaryota,3822D@33090|Viridiplantae,34NGR@3041|Chlorophyta	2759|Eukaryota	S	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
k59_1001832_1	1229909.NSED_08980	1.87e-63	202.0	COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota	651137|Thaumarchaeota	F	aspartate carbamoyltransferase	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1001832_2	436308.Nmar_1687	3.45e-29	107.0	COG1781@1|root,arCOG04229@2157|Archaea,41SJT@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
k59_154023_1	1255043.TVNIR_2869	2.38e-15	80.5	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WW4I@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_23687_1	555779.Dthio_PD3341	1.66e-39	143.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,42RUS@68525|delta/epsilon subdivisions,2WNWT@28221|Deltaproteobacteria,2MA7S@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_903158_2	580332.Slit_1785	3.24e-08	56.6	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2VHXK@28216|Betaproteobacteria	28216|Betaproteobacteria	G	hydroxypyruvate reductase	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_55425_1	305900.GV64_20990	2.1e-34	119.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,1XKKY@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_55425_2	265072.Mfla_2219	1.41e-45	149.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,2KMZW@206350|Nitrosomonadales	206350|Nitrosomonadales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_55425_3	1121004.ATVC01000007_gene1133	3.9e-06	48.5	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,2KPH9@206351|Neisseriales	206351|Neisseriales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_938078_1	1282876.BAOK01000001_gene2154	8.38e-33	134.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,4BPAV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	ntrY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_513529_1	224911.27351823	4.82e-13	77.0	COG0823@1|root,COG2911@1|root,COG2931@1|root,COG3209@1|root,COG0823@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3JUXC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	MQ	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k59_121390_1	589865.DaAHT2_0109	1.83e-47	169.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2MMVZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-1	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
k59_121390_2	1121403.AUCV01000001_gene865	2.32e-41	141.0	COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria,2MNKA@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
k59_315214_1	479434.Sthe_0996	1.31e-103	304.0	COG0479@1|root,COG0479@2|Bacteria,2G659@200795|Chloroflexi,27XI2@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10
k59_1001856_2	1122214.AQWH01000005_gene1206	6e-17	81.3	COG3090@1|root,COG3090@2|Bacteria,1NCEM@1224|Proteobacteria,2UFJP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG3090 TRAP-type C4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_840398_1	1454004.AW11_01908	9.86e-68	224.0	COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,1KQW8@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Flavin containing amine oxidoreductase	hpnE	-	1.17.8.1	ko:K21677	-	-	-	-	ko00000,ko01000	-	-	-	Amino_oxidase
k59_55451_1	929703.KE386491_gene1724	1.32e-31	127.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia	976|Bacteroidetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_412128_1	709032.Sulku_1032	9.34e-44	153.0	COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,42N9F@68525|delta/epsilon subdivisions,2YNBZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_316056_2	330214.NIDE3733	8.91e-32	112.0	COG0636@1|root,COG0636@2|Bacteria,3J198@40117|Nitrospirae	40117|Nitrospirae	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_316056_3	330214.NIDE3734	2.49e-39	137.0	COG0356@1|root,COG0356@2|Bacteria,3J0RW@40117|Nitrospirae	40117|Nitrospirae	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_771310_1	876044.IMCC3088_579	3.96e-57	186.0	COG0300@1|root,COG0300@2|Bacteria,1QTV7@1224|Proteobacteria,1T1IA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_678022_1	472759.Nhal_0506	1.29e-141	411.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_579855_1	330214.NIDE0302	5.4e-34	130.0	COG0621@1|root,COG0621@2|Bacteria,3J0CD@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_162091_1	1283300.ATXB01000001_gene875	9.69e-91	280.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1XEMR@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_750873_1	1380394.JADL01000001_gene2680	2.82e-96	291.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,2JWJ1@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_539882_1	945713.IALB_3198	2.52e-136	399.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_879575_1	316067.Geob_0477	1.04e-07	58.9	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2WKAK@28221|Deltaproteobacteria,43UXH@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_97706_1	330214.NIDE3446	7.55e-62	199.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
k59_946503_1	686340.Metal_0985	2.03e-54	182.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1THGR@1236|Gammaproteobacteria,1XDV9@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_946503_2	179408.Osc7112_2555	3.86e-29	109.0	COG1335@1|root,COG1335@2|Bacteria,1G3QK@1117|Cyanobacteria,1HEG7@1150|Oscillatoriales	1117|Cyanobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_979307_1	426355.Mrad2831_3238	8.08e-132	397.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,1JRYH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	MA20_38000	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_718230_1	240015.ACP_2765	1.91e-72	243.0	COG0542@1|root,COG0542@2|Bacteria,3Y35D@57723|Acidobacteria,2JIRK@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_454658_1	675635.Psed_5549	6.02e-112	343.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4DXF9@85010|Pseudonocardiales	201174|Actinobacteria	C	ferredoxin oxidoreductase	korA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_282512_1	926569.ANT_21930	9.46e-79	255.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	3.2.1.81,3.2.1.97	ko:K01219,ko:K17624	-	-	-	-	ko00000,ko01000	-	GH101	-	Big_2,CBM_6,Cytochrome_C7,F5_F8_type_C,Glyco_hyd_101C,Glyco_hydro_101,WxL
k59_1009754_1	399795.CtesDRAFT_PD1697	4.4e-35	132.0	COG3181@1|root,COG3181@2|Bacteria,1Q9D1@1224|Proteobacteria,2VP3Q@28216|Betaproteobacteria,4ACUV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_685597_1	243230.DR_2630	9.14e-27	106.0	COG0207@1|root,COG0207@2|Bacteria,1WM4Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_685597_2	626887.J057_04010	1.32e-48	163.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_31977_1	1144275.COCOR_07028	7.92e-76	241.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,2YUKJ@29|Myxococcales	28221|Deltaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2,4.3.1.1	ko:K01679,ko:K01744	ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R00490,R01082	RC00316,RC00443,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_979315_1	1268635.Loa_01916	4.88e-23	99.4	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1JDIH@118969|Legionellales	118969|Legionellales	Q	ABC transporter	yrbF	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_418618_1	1234364.AMSF01000085_gene2877	1.87e-22	99.0	COG0308@1|root,COG1277@1|root,COG0308@2|Bacteria,COG1277@2|Bacteria,1PTWJ@1224|Proteobacteria,1RZH5@1236|Gammaproteobacteria,1X55X@135614|Xanthomonadales	135614|Xanthomonadales	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,Peptidase_M1
k59_63421_1	1198452.Jab_2c30770	2.8e-86	263.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,475IE@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_97724_1	102232.GLO73106DRAFT_00037110	5.88e-32	115.0	COG3657@1|root,COG3657@2|Bacteria,1G6YT@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
k59_97724_2	493475.GARC_1437	4.12e-09	52.4	COG4115@1|root,COG4115@2|Bacteria,1MZBP@1224|Proteobacteria,1S9Q7@1236|Gammaproteobacteria,46B6R@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K19158	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YoeB_toxin
k59_879600_1	314285.KT71_04950	4.28e-94	296.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA helicase	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_63424_1	33905.BTHE_1026	3.74e-57	191.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4CZF5@85004|Bifidobacteriales	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_946524_1	404589.Anae109_4094	8.67e-91	295.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2WIQY@28221|Deltaproteobacteria,2YTXB@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_357952_1	1449065.JMLL01000010_gene173	4.77e-62	201.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,2TT6S@28211|Alphaproteobacteria,43IEI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_194271_1	572477.Alvin_3033	0.00038	44.7	COG2433@1|root,COG2433@2|Bacteria,1N0ZS@1224|Proteobacteria,1S7FF@1236|Gammaproteobacteria,1WYCM@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
k59_1027625_1	395495.Lcho_4061	1.68e-34	121.0	COG0346@1|root,COG0346@2|Bacteria,1RABQ@1224|Proteobacteria,2VS4J@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1027625_2	497321.C664_10797	1.68e-30	118.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,2KVBW@206389|Rhodocyclales	206389|Rhodocyclales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_31994_1	631454.N177_2533	4.69e-115	342.0	COG0404@1|root,COG0404@2|Bacteria,1N705@1224|Proteobacteria,2TQT7@28211|Alphaproteobacteria,1JPYD@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C,SnoaL_2
k59_255279_1	1185652.USDA257_c23780	1.34e-06	50.1	COG1225@1|root,COG1225@2|Bacteria,1N86B@1224|Proteobacteria,2TVN1@28211|Alphaproteobacteria,4BI21@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_226587_1	1300345.LF41_2530	2.31e-60	200.0	COG0520@1|root,COG0520@2|Bacteria,1R4SM@1224|Proteobacteria,1RQR6@1236|Gammaproteobacteria,1X8KQ@135614|Xanthomonadales	135614|Xanthomonadales	E	Aminotransferase class-V	-	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_651282_2	330214.NIDE1937	1.93e-35	135.0	COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_979337_1	1123020.AUIE01000031_gene2801	1e-13	70.1	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,1RNJJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030,ko:K09969	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k59_255287_1	631362.Thi970DRAFT_03870	3.3e-60	209.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales	135613|Chromatiales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_129657_1	987059.RBXJA2T_12137	9.69e-65	210.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,1KJX3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_879618_1	309801.trd_1137	1.49e-25	102.0	COG1175@1|root,COG1175@2|Bacteria,2GA2Q@200795|Chloroflexi,27Z2H@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_879618_2	309801.trd_1136	6.63e-65	207.0	COG0395@1|root,COG0395@2|Bacteria,2GBU5@200795|Chloroflexi,27YRY@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_946547_2	207559.Dde_0315	6.28e-43	152.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,42MPA@68525|delta/epsilon subdivisions,2WJ0Q@28221|Deltaproteobacteria,2M83W@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1009791_1	640081.Dsui_2413	1.16e-131	386.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,2KUIZ@206389|Rhodocyclales	206389|Rhodocyclales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_63455_1	5762.XP_002671270.1	1.8e-13	75.5	KOG1225@1|root,KOG2177@1|root,KOG4659@1|root,KOG1225@2759|Eukaryota,KOG2177@2759|Eukaryota,KOG4659@2759|Eukaryota	2759|Eukaryota	S	Teneurin transmembrane protein	-	GO:0000003,GO:0000902,GO:0000904,GO:0003006,GO:0003008,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005886,GO:0006928,GO:0006935,GO:0007275,GO:0007276,GO:0007399,GO:0007409,GO:0007411,GO:0007413,GO:0007548,GO:0007588,GO:0008037,GO:0008038,GO:0008045,GO:0008150,GO:0008406,GO:0008584,GO:0008585,GO:0009605,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009886,GO:0009887,GO:0009987,GO:0010171,GO:0010172,GO:0010927,GO:0016020,GO:0016043,GO:0016477,GO:0019953,GO:0022008,GO:0022414,GO:0022607,GO:0030030,GO:0030154,GO:0030182,GO:0030198,GO:0030421,GO:0031175,GO:0032501,GO:0032502,GO:0032504,GO:0032989,GO:0032990,GO:0035295,GO:0040011,GO:0040032,GO:0040039,GO:0042221,GO:0042330,GO:0043062,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044424,GO:0044464,GO:0044703,GO:0045137,GO:0046545,GO:0046546,GO:0046660,GO:0046661,GO:0048468,GO:0048513,GO:0048563,GO:0048565,GO:0048569,GO:0048598,GO:0048608,GO:0048609,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0055123,GO:0060465,GO:0061458,GO:0061564,GO:0070831,GO:0071711,GO:0071840,GO:0071944,GO:0097485,GO:0106030,GO:0120036,GO:0120039,GO:2001197	-	ko:K02599	ko01522,ko04320,ko04330,ko04658,ko04919,ko05020,ko05165,ko05200,ko05206,ko05224,map01522,map04320,map04330,map04658,map04919,map05020,map05165,map05200,map05206,map05224	M00682	-	-	ko00000,ko00001,ko00002	-	-	-	BTB,EGF_2,NHL,Pkinase,Tox-GHH
k59_226612_1	85643.Tmz1t_0554	9.53e-57	189.0	COG0827@1|root,COG0827@2|Bacteria,1QP3Z@1224|Proteobacteria,2VI9V@28216|Betaproteobacteria,2KVWP@206389|Rhodocyclales	206389|Rhodocyclales	L	Eco57I restriction-modification methylase	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I
k59_946552_1	83406.HDN1F_03580	8.64e-109	347.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1J52Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_97767_1	330214.NIDE2770	4.83e-40	135.0	COG2105@1|root,COG2105@2|Bacteria	2|Bacteria	F	PFAM AIG2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT,Gamma_PGA_hydro
k59_97767_2	330214.NIDE2772	8.09e-72	216.0	COG3411@1|root,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	fdx4	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
k59_357986_1	1125863.JAFN01000001_gene2445	2.26e-131	376.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_685647_1	1132855.KB913035_gene221	5.77e-79	253.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,2KMCJ@206350|Nitrosomonadales	206350|Nitrosomonadales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_418652_1	266117.Rxyl_0217	2.07e-73	230.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4CQ61@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-dependent oxidoreductase, G6PDH family	-	-	1.1.98.2	ko:K15510	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
k59_879633_1	292415.Tbd_2584	2.37e-59	199.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,1KRJE@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Carbon-nitrogen hydrolase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_750948_1	1000565.METUNv1_02456	1.95e-28	115.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	-	-	-	-	-	-	-	-	-	GAF,T2SSE,T2SSE_N
k59_750948_2	580332.Slit_0535	1.65e-15	75.9	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,2VQGZ@28216|Betaproteobacteria	28216|Betaproteobacteria	PT	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_619076_1	396588.Tgr7_0597	2.41e-23	97.1	28J26@1|root,2Z8YT@2|Bacteria,1R7S5@1224|Proteobacteria,1RNDH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2914
k59_255309_1	768710.DesyoDRAFT_5344	3.03e-94	288.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,2609R@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_32050_1	1120956.JHZK01000014_gene1784	6.63e-31	122.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TT21@28211|Alphaproteobacteria,1JP1T@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585,ko:K18901	ko01501,ko01503,map01501,map01503	M00646,M00647,M00698,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_418656_1	748280.NH8B_2691	4.23e-299	851.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,2KQ33@206351|Neisseriales	206351|Neisseriales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_129700_1	330214.NIDE0277	4.25e-56	197.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
k59_879658_1	696281.Desru_1662	4.7e-164	470.0	COG0526@1|root,COG0526@2|Bacteria,1TRBZ@1239|Firmicutes,249GQ@186801|Clostridia,264DZ@186807|Peptococcaceae	186801|Clostridia	CO	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotran_2,Arylsulfotrans,Thioredoxin
k59_779388_1	265072.Mfla_2050	3.42e-158	464.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KKKI@206350|Nitrosomonadales	206350|Nitrosomonadales	CP	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_779388_2	426114.THI_2629	1.07e-16	73.6	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2VSDV@28216|Betaproteobacteria,1KM2T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_540810_1	1415779.JOMH01000001_gene799	5.47e-162	461.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,1RY10@1236|Gammaproteobacteria,1X3VX@135614|Xanthomonadales	135614|Xanthomonadales	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_256779_1	1121920.AUAU01000004_gene590	1.45e-80	254.0	COG1171@1|root,COG1171@2|Bacteria,3Y2RI@57723|Acidobacteria	57723|Acidobacteria	E	beta' subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_540811_1	748247.AZKH_0507	1.63e-88	277.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KV59@206389|Rhodocyclales	206389|Rhodocyclales	I	poly(R)-hydroxyalkanoic acid synthase	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_324593_1	1123393.KB891316_gene1331	1.76e-54	179.0	COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2VRGI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
k59_881310_1	859657.RPSI07_mp1366	1.06e-79	249.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_912791_1	1163617.SCD_n02945	5.82e-55	190.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria	28216|Betaproteobacteria	U	type IV pilus secretin PilQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_912791_2	1266925.JHVX01000003_gene480	1.72e-17	79.3	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,372TS@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_228499_1	675635.Psed_3035	6.92e-15	74.7	COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,2GKV9@201174|Actinobacteria,4E8N2@85010|Pseudonocardiales	201174|Actinobacteria	I	Coenzyme A transferase	pcaJ	-	2.8.3.5,2.8.3.6	ko:K01027,ko:K01029,ko:K01032	ko00072,ko00280,ko00362,ko00650,ko01100,ko01120,map00072,map00280,map00362,map00650,map01100,map01120	-	R00410,R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_228499_2	1123504.JQKD01000005_gene4908	2.14e-16	80.9	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VNKP@28216|Betaproteobacteria,4ABUE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_283465_1	580332.Slit_0351	1.24e-77	240.0	COG0304@1|root,COG0304@2|Bacteria,1NP8M@1224|Proteobacteria,2VJDN@28216|Betaproteobacteria,44W98@713636|Nitrosomonadales	28216|Betaproteobacteria	IQ	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_2
k59_779437_1	1232410.KI421415_gene3078	1.2e-66	212.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2WJRU@28221|Deltaproteobacteria,43S52@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Glycosyl transferase family, helical bundle domain	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2495	GATase,Glycos_trans_3N,Glycos_transf_3
k59_779437_2	1232410.KI421415_gene3079	1.16e-13	67.8	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,43TCX@69541|Desulfuromonadales	28221|Deltaproteobacteria	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2496	GATase
k59_540836_1	941824.TCEL_01651	2.48e-12	71.2	COG0297@1|root,COG0297@2|Bacteria,1UHWI@1239|Firmicutes,25EKA@186801|Clostridia,36UWQ@31979|Clostridiaceae	186801|Clostridia	G	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_324650_1	1123368.AUIS01000031_gene1420	1.02e-66	220.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales	225057|Acidithiobacillales	P	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1011541_1	573064.Mefer_0153	5.91e-08	59.3	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,23QPF@183939|Methanococci	183939|Methanococci	C	PFAM glutamate synthase alpha subunit domain protein	fwdC	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
k59_881370_1	926569.ANT_09980	1.23e-99	320.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_912838_1	177437.HRM2_26080	1.48e-52	192.0	COG2366@1|root,COG2366@2|Bacteria,1R9UG@1224|Proteobacteria,42PRB@68525|delta/epsilon subdivisions,2WJCS@28221|Deltaproteobacteria,2MHYM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_912846_1	682795.AciX8_0375	5.71e-91	284.0	COG0481@1|root,COG0481@2|Bacteria,3Y3EX@57723|Acidobacteria,2JI4G@204432|Acidobacteriia	204432|Acidobacteriia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_228563_1	261292.Nit79A3_1043	1.29e-63	197.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,37350@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
k59_228563_2	75379.Tint_0868	1.52e-29	113.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,1KKTY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
k59_228563_3	999541.bgla_1g03870	4.06e-24	93.2	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,1K977@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_228563_4	1156919.QWC_12898	3.33e-25	102.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,3T4FJ@506|Alcaligenaceae	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_228563_5	748247.AZKH_0766	9.16e-55	179.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,2KUWA@206389|Rhodocyclales	206389|Rhodocyclales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_456793_1	946483.Cenrod_0066	5.08e-41	147.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,4AJA8@80864|Comamonadaceae	28216|Betaproteobacteria	L	Group II intron, maturase-specific domain	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,Intron_maturas2,RVT_1
k59_624290_1	713586.KB900536_gene1939	1.35e-08	59.7	COG0664@1|root,COG0664@2|Bacteria,1PDUV@1224|Proteobacteria,1SS1D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_101972_1	395961.Cyan7425_2988	4.84e-58	200.0	COG4122@1|root,COG4122@2|Bacteria,1GBCN@1117|Cyanobacteria	1117|Cyanobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_657122_1	640081.Dsui_3392	1.01e-109	327.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria,2KVTN@206389|Rhodocyclales	206389|Rhodocyclales	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	ybdK	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
k59_69444_1	665571.STHERM_c17110	1.25e-98	294.0	COG0214@1|root,COG0214@2|Bacteria,2J5SI@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
k59_493962_2	945713.IALB_0618	3.54e-41	146.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_852602_1	857087.Metme_1126	2.19e-41	144.0	COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,1S48U@1236|Gammaproteobacteria,1XFI1@135618|Methylococcales	135618|Methylococcales	K	RNA polymerase sigma factor 70, region 4 type 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_362897_1	96561.Dole_2570	1.44e-126	381.0	COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,42M8V@68525|delta/epsilon subdivisions,2WJ7S@28221|Deltaproteobacteria,2MHTW@213118|Desulfobacterales	28221|Deltaproteobacteria	F	anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
k59_3994_1	497321.C664_04072	6.47e-122	372.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,2KU6T@206389|Rhodocyclales	206389|Rhodocyclales	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_559199_1	251229.Chro_0877	1.02e-44	162.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,3VINJ@52604|Pleurocapsales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_983130_1	795666.MW7_2272	3.53e-54	188.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2VIMQ@28216|Betaproteobacteria,1K023@119060|Burkholderiaceae	28216|Betaproteobacteria	S	abc transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
k59_820416_1	395493.BegalDRAFT_2951	3.27e-71	226.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,45ZZM@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_820416_2	160492.XF_1955	1.16e-17	77.8	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1X6HP@135614|Xanthomonadales	135614|Xanthomonadales	KT	response regulator	pilG	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_950744_1	95619.PM1_0206625	6.07e-126	368.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
k59_559206_1	1288494.EBAPG3_4460	1.94e-21	93.6	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,371Z6@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_559206_2	580332.Slit_1736	2.76e-77	236.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,44VQU@713636|Nitrosomonadales	28216|Betaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_559206_3	426114.THI_1700	2.84e-23	90.1	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2VVS9@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_559206_4	1236959.BAMT01000016_gene2805	4.91e-58	182.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,2KMT0@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_559206_5	62928.azo1083	2.82e-05	46.2	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,2KUG4@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_624337_1	272560.BPSL1810	7.08e-16	81.3	COG4961@1|root,COG4961@2|Bacteria,1RKE7@1224|Proteobacteria,2VZN3@28216|Betaproteobacteria,1K3TC@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Putative Tad-like Flp pilus-assembly	-	-	-	-	-	-	-	-	-	-	-	-	Tad,Tad_C
k59_591718_1	945713.IALB_0510	9.21e-100	295.0	COG0370@1|root,COG0370@2|Bacteria	2|Bacteria	P	ferrous iron transmembrane transporter activity	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_330422_1	977880.RALTA_A2589	1.48e-35	124.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,1K7SV@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_330422_2	261292.Nit79A3_0480	3.86e-70	222.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,372EF@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_885121_1	945713.IALB_2365	2.9e-43	151.0	COG1739@1|root,COG1739@2|Bacteria	2|Bacteria	S	Uncharacterized protein family UPF0029	yigZ	-	2.1.1.45,3.4.13.9	ko:K00560,ko:K01271	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	DUF1949,UPF0029
k59_689834_1	224911.27351004	2.98e-76	234.0	COG1028@1|root,COG1028@2|Bacteria,1QWBB@1224|Proteobacteria,2U2FD@28211|Alphaproteobacteria,3JSE3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_17420	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_460532_2	1869.MB27_01440	1.68e-127	388.0	COG3459@1|root,COG3459@2|Bacteria,2IAZ0@201174|Actinobacteria,4DHXT@85008|Micromonosporales	201174|Actinobacteria	G	Putative carbohydrate binding domain	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
k59_885132_1	933262.AXAM01000036_gene2170	1.61e-78	261.0	COG0613@1|root,COG0613@2|Bacteria,1Q7I9@1224|Proteobacteria,42M1D@68525|delta/epsilon subdivisions,2WIMC@28221|Deltaproteobacteria,2MIFA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_199930_1	323261.Noc_1791	8.52e-85	264.0	COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria,1SJKT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_885135_1	1121004.ATVC01000003_gene463	1.13e-30	118.0	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,2KQHK@206351|Neisseriales	206351|Neisseriales	C	cb-type cytochrome c oxidase subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_69528_1	1120966.AUBU01000006_gene3214	5.63e-85	268.0	28ICA@1|root,2Z8EP@2|Bacteria,4NFBS@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_657214_1	243090.RB2182	8.74e-05	45.4	COG3293@1|root,COG3293@2|Bacteria,2IX9I@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_657214_2	1504672.669784874	2.45e-28	111.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2VP2D@28216|Betaproteobacteria,4AEEG@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_494042_1	1380394.JADL01000002_gene1267	4.76e-80	255.0	COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,2JP9Q@204441|Rhodospirillales	204441|Rhodospirillales	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
k59_4066_2	1283300.ATXB01000002_gene2631	1.22e-44	152.0	COG1814@1|root,COG1814@2|Bacteria,1RBQN@1224|Proteobacteria,1S2ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_265296_1	765698.Mesci_2924	9.71e-32	119.0	COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,2U0MC@28211|Alphaproteobacteria,43J4M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
k59_265296_2	1057002.KB905370_gene2377	2.67e-152	456.0	COG0076@1|root,COG0454@1|root,COG0076@2|Bacteria,COG0454@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,4B92C@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	decarboxylase	rhbB	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
k59_265296_3	1211115.ALIQ01000190_gene913	1.03e-38	143.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,3N9Q8@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_559259_1	371731.Rsw2DRAFT_2901	6.9e-06	48.9	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,1FC8K@1060|Rhodobacter	28211|Alphaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	MA20_09455	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_559259_2	1392838.AWNM01000075_gene396	1.78e-44	155.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,3T1GT@506|Alcaligenaceae	28216|Betaproteobacteria	V	ABC-type multidrug transport system, permease component	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_754271_2	579138.Zymop_0823	2.78e-15	76.6	COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2TV42@28211|Alphaproteobacteria,2K7D4@204457|Sphingomonadales	204457|Sphingomonadales	S	TIGRFAM phage terminase, large subunit, PBSX family	-	-	-	ko:K06909	-	-	-	-	ko00000	-	-	-	Terminase_3
k59_102062_1	85643.Tmz1t_3871	1.04e-54	183.0	COG2067@1|root,COG2067@2|Bacteria,1REWT@1224|Proteobacteria,2VVIS@28216|Betaproteobacteria	28216|Betaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_494049_1	497321.C664_11505	1.19e-124	362.0	COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2VIRJ@28216|Betaproteobacteria,2KYJV@206389|Rhodocyclales	206389|Rhodocyclales	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.312	ko:K10219	ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220	M00533	R04278,R04279,R04418,R04419	RC00251,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA
k59_102065_1	85643.Tmz1t_3378	1.5e-76	254.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales	206389|Rhodocyclales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_951774_1	1469245.JFBG01000062_gene2270	6.89e-78	243.0	COG2358@1|root,COG2358@2|Bacteria	2|Bacteria	G	TRAP transporter, solute receptor (TAXI family	MA20_27285	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_560235_1	272633.26454360	7.44e-25	104.0	COG0484@1|root,COG0484@2|Bacteria,3WSX8@544448|Tenericutes	544448|Tenericutes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_560235_2	1184607.AUCHE_17_01360	5.3e-06	51.6	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4F639@85018|Dermatophilaceae	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1014202_1	279714.FuraDRAFT_0324	1.85e-212	607.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,2KQ3F@206351|Neisseriales	206351|Neisseriales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_1014202_2	1122604.JONR01000045_gene2493	1.05e-46	159.0	2A20V@1|root,30QAU@2|Bacteria,1RDQH@1224|Proteobacteria,1T055@1236|Gammaproteobacteria,1X6SQ@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_298516_1	543913.D521_0651	6.77e-87	271.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,1KQI6@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,HD_5
k59_429172_1	640511.BC1002_5536	2.47e-25	105.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_429172_2	697282.Mettu_3716	8.55e-17	81.3	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
k59_821438_2	102232.GLO73106DRAFT_00027360	4.26e-11	63.9	COG1950@1|root,COG1950@2|Bacteria,1G7RB@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_70530_1	880072.Desac_0603	6.65e-34	132.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2MQXI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
k59_984130_1	1444309.JAQG01000003_gene4442	6.86e-20	94.4	COG3385@1|root,COG3385@2|Bacteria,1VDW5@1239|Firmicutes,4HMDF@91061|Bacilli,26SXH@186822|Paenibacillaceae	91061|Bacilli	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_886026_1	330214.NIDE3296	1.08e-41	155.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
k59_821442_1	395493.BegalDRAFT_0735	1.58e-50	167.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,462B7@72273|Thiotrichales	72273|Thiotrichales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	-	-	-	-	-	-	-	-	-	CcmB
k59_919407_1	861299.J421_0784	4.17e-33	128.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
k59_266241_1	1121937.AUHJ01000036_gene2808	7.11e-63	201.0	2CIH3@1|root,32KXU@2|Bacteria,1RJBB@1224|Proteobacteria,1S7QK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_266242_1	85643.Tmz1t_3337	5.72e-63	198.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2VHS6@28216|Betaproteobacteria,2KVFP@206389|Rhodocyclales	206389|Rhodocyclales	J	50S ribosomal protein L4	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_266242_2	1132855.KB913035_gene2493	1.62e-23	95.1	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2VJ3V@28216|Betaproteobacteria,2KKMB@206350|Nitrosomonadales	206350|Nitrosomonadales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_37747_1	335283.Neut_0307	2.68e-134	385.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,371P4@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Methionine aminopeptidase	map	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_429193_1	991905.SL003B_4136	2.25e-185	521.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,4BT5R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_3
k59_821467_1	977880.RALTA_A2284	7.22e-50	176.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIA6@28216|Betaproteobacteria,1K2QB@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Activates fatty acids by binding to coenzyme A	fadD2	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_37748_1	297246.lpp2046	2.2e-09	60.8	COG3293@1|root,COG3293@2|Bacteria,1P5HD@1224|Proteobacteria,1RSHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_37748_2	192952.MM_2231	1.43e-35	130.0	COG3293@1|root,arCOG03506@2157|Archaea	2157|Archaea	L	Transposase DDE domain	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF4096
k59_984154_1	420324.KI911934_gene172	1.4e-80	251.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JXEF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_919430_2	395963.Bind_2328	6.29e-10	63.2	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2TV55@28211|Alphaproteobacteria,3NB9I@45404|Beijerinckiaceae	28211|Alphaproteobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_625352_1	1229909.NSED_08845	8.39e-18	83.6	arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_298560_1	1417296.U879_08050	9.87e-122	357.0	COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria,2U1YU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
k59_298560_2	1163617.SCD_n00804	2.8e-14	75.5	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2VJIX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	geranylgeranyl reductase	-	-	1.3.1.111,1.3.1.83	ko:K10960	ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110	-	R02063,R08754,R08755,R08756,R11226,R11518	RC00212,RC00522,RC01823	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Lycopene_cycl,NAD_binding_8
k59_755054_3	439235.Dalk_1624	6.21e-13	69.7	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQ2S@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_5129_1	99598.Cal7507_0152	1.52e-09	55.5	COG1942@1|root,COG1942@2|Bacteria,1G96X@1117|Cyanobacteria,1HPCE@1161|Nostocales	1117|Cyanobacteria	S	4-oxalocrotonate tautomerase family	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_723425_1	330214.NIDE3038	3.2e-75	235.0	COG0673@1|root,COG0673@2|Bacteria,3J0M7@40117|Nitrospirae	40117|Nitrospirae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_919453_1	497965.Cyan7822_3035	1.37e-89	292.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,3KGSH@43988|Cyanothece	1117|Cyanobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN678.nifJ	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_853670_1	443143.GM18_0377	1.8e-26	110.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y50@68525|delta/epsilon subdivisions,2WUBF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HTH_8,PAS_4,Sigma54_activat
k59_625371_1	1047013.AQSP01000139_gene2391	1.45e-16	78.2	COG0460@1|root,COG0460@2|Bacteria,2NP8S@2323|unclassified Bacteria	2|Bacteria	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
k59_625371_2	1134413.ANNK01000162_gene3529	1.56e-63	210.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1ZAXK@1386|Bacillus	91061|Bacilli	C	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively	gabD_2	-	1.2.1.9	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	M00308,M00633	R01058	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_951859_1	358220.C380_13365	1.8e-19	83.6	COG2050@1|root,COG2050@2|Bacteria,1RKWK@1224|Proteobacteria,2VSST@28216|Betaproteobacteria,4AEM8@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_208550_2	436308.Nmar_0061	3.43e-101	296.0	COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_530601_1	648757.Rvan_0473	6.81e-64	206.0	COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2TWFW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_78638_1	998088.B565_3193	1.67e-42	152.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1Y3F5@135624|Aeromonadales	135624|Aeromonadales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_13251_1	794903.OPIT5_11255	1.69e-93	287.0	COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_78639_1	1188256.BASI01000002_gene3323	0.000664	43.9	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TVI7@28211|Alphaproteobacteria,3FDAK@34008|Rhodovulum	28211|Alphaproteobacteria	M	AsmA-like C-terminal region	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_78639_2	640510.BC1001_0305	8.26e-121	358.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2VH21@28216|Betaproteobacteria,1K2KI@119060|Burkholderiaceae	28216|Betaproteobacteria	L	a g-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_305839_2	107635.AZUO01000001_gene3079	6.52e-45	157.0	COG1411@1|root,COG1411@2|Bacteria,1RHWE@1224|Proteobacteria,2U80I@28211|Alphaproteobacteria,3708N@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Histidine biosynthesis protein	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_731484_1	697282.Mettu_3989	7.38e-32	120.0	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1S2JW@1236|Gammaproteobacteria,1XG9F@135618|Methylococcales	135618|Methylococcales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_991783_1	323848.Nmul_A2478	1.47e-56	181.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,372DD@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	algH	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_503068_1	545264.KB898753_gene1726	3.05e-45	166.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1SMM0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_893488_1	1380355.JNIJ01000046_gene1354	2.68e-110	336.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_23145	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_600656_1	264198.Reut_B4651	7.88e-125	383.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Formate dehydrogenase, alpha subunit	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_761412_1	177437.HRM2_38690	4.27e-74	233.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,42Q6C@68525|delta/epsilon subdivisions,2WMD6@28221|Deltaproteobacteria,2MHY6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_927456_1	795666.MW7_1790	1.53e-72	220.0	COG1786@1|root,COG1786@2|Bacteria,1RFUH@1224|Proteobacteria,2VSAS@28216|Betaproteobacteria,1KBB8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
k59_927456_2	1236902.ANAS01000030_gene2985	6.04e-05	45.1	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4EFJ2@85012|Streptosporangiales	201174|Actinobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_829614_1	1454004.AW11_03257	1.18e-170	491.0	COG2885@1|root,COG2885@2|Bacteria,1QVSX@1224|Proteobacteria	1224|Proteobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,OmpA
k59_239175_1	335543.Sfum_2437	5.43e-80	265.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MRHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
k59_666320_1	1057002.KB905371_gene115	1.91e-11	60.1	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_666320_2	986075.CathTA2_2614	1.68e-18	87.4	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli	91061|Bacilli	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	appC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_305876_1	580332.Slit_2777	1.14e-96	297.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria	28216|Betaproteobacteria	O	serine protease	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_927481_1	1232410.KI421415_gene3005	5.29e-101	301.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,43SE0@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium Bile acid symporter family	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_960046_1	471854.Dfer_2588	0.000181	44.3	COG1028@1|root,COG1028@2|Bacteria,4NEAI@976|Bacteroidetes,47MF7@768503|Cytophagia	976|Bacteroidetes	IQ	TIGRFAM 3-oxoacyl-(acyl-carrier-protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_960046_2	565655.ECBG_02719	2.07e-13	72.4	COG1028@1|root,COG1028@2|Bacteria,1TP2V@1239|Firmicutes,4HCAG@91061|Bacilli,4B0JI@81852|Enterococcaceae	91061|Bacilli	IQ	KR domain	-	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	adh_short
k59_143695_1	330214.NIDE0853	3.56e-44	155.0	COG4105@1|root,COG4105@2|Bacteria,3J0UU@40117|Nitrospirae	40117|Nitrospirae	S	Tetratricopeptide repeat	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_991821_1	1316936.K678_05006	2.7e-183	521.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales	204441|Rhodospirillales	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_600699_1	472759.Nhal_2084	2.37e-52	185.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales	135613|Chromatiales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_467680_1	1121943.KB899991_gene2417	2.68e-71	220.0	COG4122@1|root,COG4122@2|Bacteria,1N57D@1224|Proteobacteria,1S6JT@1236|Gammaproteobacteria,1XK1C@135619|Oceanospirillales	135619|Oceanospirillales	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
k59_503114_1	1041930.Mtc_0573	2.32e-67	218.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N918@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_78698_2	309799.DICTH_0852	6.19e-14	71.2	COG0097@1|root,COG0097@2|Bacteria	2|Bacteria	J	rRNA binding	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_600704_1	1123393.KB891317_gene2463	1.08e-81	251.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,1KRKH@119069|Hydrogenophilales	119069|Hydrogenophilales	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
k59_46592_1	762376.AXYL_05631	1.8e-70	228.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2VKAQ@28216|Betaproteobacteria,3T3RA@506|Alcaligenaceae	28216|Betaproteobacteria	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_634049_1	762966.HMPREF9439_01700	3.46e-34	120.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2VPZW@28216|Betaproteobacteria,4PQZM@995019|Sutterellaceae	28216|Betaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_634049_2	1121127.JAFA01000073_gene7559	2.79e-42	145.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2VHDK@28216|Betaproteobacteria,1K0FR@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_340346_1	768671.ThimaDRAFT_2402	2.76e-05	47.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1T54V@1236|Gammaproteobacteria,1X2UH@135613|Chromatiales	135613|Chromatiales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_340346_2	522306.CAP2UW1_3430	2.24e-98	300.0	COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,2VPY4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_700205_1	882.DVU_2007	1.66e-08	53.9	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,42SG5@68525|delta/epsilon subdivisions,2WNPI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM nuclease (SNase domain protein)	-	-	-	-	-	-	-	-	-	-	-	-	Ada_Zn_binding,Excalibur,SNase
k59_700205_2	1123269.NX02_14300	2.02e-15	81.3	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2K2CT@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k59_830695_1	1212548.B381_19721	2.01e-12	70.9	COG2885@1|root,COG2885@2|Bacteria,1PGGZ@1224|Proteobacteria,1RNFU@1236|Gammaproteobacteria,1Z072@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Belongs to the ompA family	motY	-	-	ko:K21218	ko02040,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
k59_667410_1	713586.KB900536_gene1818	7.04e-90	279.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_144708_2	582899.Hden_2377	6.47e-96	289.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,3N6FK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ATPase AAA	moxR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_862297_1	1121921.KB898706_gene2977	1.7e-06	53.1	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,2PNVA@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	T	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
k59_437773_1	945713.IALB_1686	4.9e-46	152.0	2ESFM@1|root,33K0C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_762303_1	1191523.MROS_1562	4.97e-35	134.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	GSu_C4xC__C2xCH
k59_14342_1	153948.NAL212_3114	2.74e-70	222.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,372PH@32003|Nitrosomonadales	28216|Betaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_273443_1	864051.BurJ1DRAFT_2346	7.84e-85	258.0	28PII@1|root,2ZCMP@2|Bacteria,1RBRM@1224|Proteobacteria,2VQP7@28216|Betaproteobacteria,1KMX0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
k59_667424_1	1515615.HQ41_05075	2.57e-32	125.0	COG0272@1|root,COG0272@2|Bacteria,4NE2X@976|Bacteroidetes,2FKZZ@200643|Bacteroidia,22WHC@171551|Porphyromonadaceae	976|Bacteroidetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_209587_1	472759.Nhal_3162	9.9e-114	342.0	COG3829@1|root,COG3829@2|Bacteria,1MXSB@1224|Proteobacteria,1RVV6@1236|Gammaproteobacteria,1WWEN@135613|Chromatiales	135613|Chromatiales	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
k59_531170_1	261292.Nit79A3_1789	1.13e-77	243.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,372I8@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_144732_2	666685.R2APBS1_3433	4.28e-100	298.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RM87@1236|Gammaproteobacteria,1X4ZK@135614|Xanthomonadales	135614|Xanthomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_830721_2	1175306.GWL_23560	1.14e-14	70.5	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2VQFV@28216|Betaproteobacteria,474FZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_601698_1	582744.Msip34_2620	3.94e-52	171.0	COG0819@1|root,COG0819@2|Bacteria,1MVA0@1224|Proteobacteria,2WGSW@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
k59_601698_2	1123257.AUFV01000005_gene1281	5.06e-44	154.0	COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,1S2HE@1236|Gammaproteobacteria,1X73Y@135614|Xanthomonadales	135614|Xanthomonadales	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_732620_1	945713.IALB_1853	5.92e-59	195.0	COG0138@1|root,COG0138@2|Bacteria	2|Bacteria	F	bifunctional purine biosynthesis protein purh	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_732620_2	945713.IALB_1852	3.73e-45	154.0	COG1077@1|root,COG1077@2|Bacteria	2|Bacteria	D	Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_403359_1	292415.Tbd_0979	9.73e-19	83.2	COG1129@1|root,COG1129@2|Bacteria,1PAYN@1224|Proteobacteria	1224|Proteobacteria	G	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_403359_2	296591.Bpro_2659	1.57e-07	53.1	COG0767@1|root,COG0767@2|Bacteria,1NSBS@1224|Proteobacteria,2VKK9@28216|Betaproteobacteria,4AABS@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_112082_1	1163617.SCD_n00468	5.34e-59	196.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_700249_1	330214.NIDE1377	4.15e-71	232.0	COG1391@1|root,COG1391@2|Bacteria	2|Bacteria	H	[glutamate-ammonia-ligase] adenylyltransferase activity	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_667442_1	1121033.AUCF01000006_gene4242	1.95e-110	331.0	COG0715@1|root,COG0715@2|Bacteria,1R4AB@1224|Proteobacteria,2U2A0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport systems periplasmic	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_961153_1	945713.IALB_3192	5.68e-143	441.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13,2.1.1.245,2.1.1.258	ko:K00197,ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00680,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00357,M00377,M00422	R00946,R02289,R09096,R09365,R10219,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_437799_1	933262.AXAM01000052_gene1988	2.65e-154	441.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_732634_1	698761.RTCIAT899_CH16070	4.51e-31	122.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TTXX@28211|Alphaproteobacteria,4BC6Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_894495_2	305700.B447_12839	1.39e-54	173.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,2KWJU@206389|Rhodocyclales	206389|Rhodocyclales	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
k59_112093_1	261292.Nit79A3_3070	6.89e-86	266.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,372F1@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_79724_1	477228.YO5_17705	2.28e-22	99.4	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1Z1NS@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	visC	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03184,ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R06146,R08768,R08775	RC00046,RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_112098_1	1223521.BBJX01000014_gene265	2.02e-26	112.0	COG2373@1|root,COG2931@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VTFV@28216|Betaproteobacteria,4AK2G@80864|Comamonadaceae	28216|Betaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind
k59_437812_1	330214.NIDE0797	1.14e-58	187.0	COG1028@1|root,COG1028@2|Bacteria,3J0J6@40117|Nitrospirae	40117|Nitrospirae	IQ	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_144760_1	177437.HRM2_02000	3.73e-45	157.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,42NI9@68525|delta/epsilon subdivisions,2WK2T@28221|Deltaproteobacteria,2MIIS@213118|Desulfobacterales	28221|Deltaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_209630_1	1123242.JH636435_gene1095	4.26e-61	203.0	COG0591@1|root,COG0591@2|Bacteria,2IYAQ@203682|Planctomycetes	203682|Planctomycetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_928590_1	1380394.JADL01000001_gene3047	1.99e-67	209.0	COG1765@1|root,COG1765@2|Bacteria,1R9XU@1224|Proteobacteria,2U6E4@28211|Alphaproteobacteria,2JS0C@204441|Rhodospirillales	204441|Rhodospirillales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_306889_1	1121396.KB893100_gene4313	1.04e-58	189.0	COG1035@1|root,COG4656@1|root,COG1035@2|Bacteria,COG4656@2|Bacteria,1NQN7@1224|Proteobacteria,42MGI@68525|delta/epsilon subdivisions,2WKNC@28221|Deltaproteobacteria,2MIJN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrD	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_17,Fer4_8,FlpD,FrhB_FdhB_C
k59_306889_2	439235.Dalk_5061	1.21e-36	134.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,2MI1V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_273471_1	977880.RALTA_A1314	4.35e-48	166.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,1K0GT@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_968864_1	330214.NIDE1868	3.95e-92	298.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae	40117|Nitrospirae	H	Pterin binding enzyme	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
k59_119594_1	1217718.ALOU01000007_gene1259	1.17e-40	146.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria,1KF02@119060|Burkholderiaceae	28216|Betaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_216938_1	1565129.JSFF01000002_gene3385	1.89e-29	121.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2QBDU@267890|Shewanellaceae	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
k59_246453_1	760568.Desku_0313	2.13e-16	82.4	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_791191_1	1395571.TMS3_0118250	4.77e-137	404.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RQR1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	type II secretion system protein	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_936234_1	1121918.ARWE01000001_gene2169	8.43e-11	65.1	COG1538@1|root,COG1538@2|Bacteria,1Q1F4@1224|Proteobacteria,42NUU@68525|delta/epsilon subdivisions,2WK3P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin)	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_936234_2	59689.fgenesh2_kg.3__2939__AT2G07680.1	0.000763	44.7	COG1132@1|root,KOG0054@2759|Eukaryota,37RZ5@33090|Viridiplantae,3GD1D@35493|Streptophyta	35493|Streptophyta	Q	ABC transporter C family member	-	GO:0000325,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0006810,GO:0008150,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0042623,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085	-	ko:K05674	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.208	-	-	ABC_membrane,ABC_tran
k59_1022436_1	671143.DAMO_0415	1.01e-113	332.0	COG0745@1|root,COG0745@2|Bacteria,2NQWD@2323|unclassified Bacteria	2|Bacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_379700_1	1094715.CM001373_gene3432	5.24e-37	142.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1JC94@118969|Legionellales	118969|Legionellales	MU	Outer membrane efflux protein	lprN	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_901506_1	436308.Nmar_0053	1.35e-119	352.0	COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
k59_53825_1	640511.BC1002_6656	1.22e-16	85.1	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VSSJ@28216|Betaproteobacteria,1K5FA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,SAM_1,TPR_12,Trans_reg_C
k59_313658_1	395019.Bmul_5339	1.08e-65	204.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2VQUA@28216|Betaproteobacteria,1K6XY@119060|Burkholderiaceae	28216|Betaproteobacteria	KT	SMART metal-dependent phosphohydrolase, HD region	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
k59_936248_1	644801.Psest_2217	1.11e-79	253.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1Z22W@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_937226_1	1031711.RSPO_c00593	1.99e-98	303.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,1K1SY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	abc transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
k59_610118_1	1232453.BAIF02000098_gene3839	2.36e-13	68.9	COG3962@1|root,COG3962@2|Bacteria,1UI18@1239|Firmicutes,25EA8@186801|Clostridia,26CS4@186813|unclassified Clostridiales	186801|Clostridia	E	Thiamine pyrophosphate enzyme, central domain	iolD	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_610118_2	483219.LILAB_25565	8.03e-67	215.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2YYIW@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_217860_1	1278073.MYSTI_01847	1.53e-173	497.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,42Q8I@68525|delta/epsilon subdivisions,2X5IX@28221|Deltaproteobacteria,2YYPK@29|Myxococcales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_153238_1	62928.azo3121	5.18e-51	168.0	COG1502@1|root,COG1502@2|Bacteria,1RG6H@1224|Proteobacteria,2VRJW@28216|Betaproteobacteria,2KWF8@206389|Rhodocyclales	206389|Rhodocyclales	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_475605_1	1123008.KB905695_gene2481	1.8e-22	94.4	COG2109@1|root,COG2109@2|Bacteria,4NN7F@976|Bacteroidetes,2FS5E@200643|Bacteroidia,22XQR@171551|Porphyromonadaceae	976|Bacteroidetes	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
k59_902432_1	1535422.ND16A_2082	2.73e-71	231.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1RSMZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_410590_1	1123242.JH636434_gene4898	9.42e-18	92.4	COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,2IX8Z@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_446013_1	391735.Veis_4002	3.66e-52	176.0	COG3181@1|root,COG3181@2|Bacteria,1MVW4@1224|Proteobacteria,2VPJZ@28216|Betaproteobacteria,4ABTW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_446013_2	1317118.ATO8_07021	7.88e-19	85.1	COG3386@1|root,COG3386@2|Bacteria,1MXVD@1224|Proteobacteria,2TVCW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	SMP-30 Gluconolaconase	MA20_17040	-	3.1.1.17	ko:K01053,ko:K02352	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_380579_2	1038869.AXAN01000235_gene5896	3.42e-53	179.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K69S@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_741415_1	251221.35213975	4.89e-44	149.0	COG2153@1|root,COG2153@2|Bacteria,1G6TQ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_410599_1	582744.Msip34_1395	1.41e-48	171.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,2VNEJ@28216|Betaproteobacteria,2KKQV@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
k59_314520_1	1123229.AUBC01000004_gene3271	3.76e-71	230.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,3JW7G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	dppA	-	-	ko:K02035,ko:K12368	ko02010,ko02024,ko02030,map02010,map02024,map02030	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_380592_1	1121430.JMLG01000019_gene1656	8.83e-58	195.0	COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,24CA4@186801|Clostridia,260IP@186807|Peptococcaceae	186801|Clostridia	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_642464_1	330214.NIDE1803	8.77e-159	456.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
k59_120618_1	1245471.PCA10_50100	2.09e-31	128.0	COG3210@1|root,COG3210@2|Bacteria,1R2YG@1224|Proteobacteria,1T5ZW@1236|Gammaproteobacteria	2|Bacteria	U	domain, Protein	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Big_2,Big_3,ChW,F5_F8_type_C,Glyco_hyd_65N_2,SLH
k59_348781_1	330214.NIDE1643	2.24e-154	451.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_676239_1	933262.AXAM01000107_gene1504	6.97e-08	53.5	COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,42MPF@68525|delta/epsilon subdivisions,2X5BJ@28221|Deltaproteobacteria,2MISB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fer4,Fer4_20,Fer4_9,Pyr_redox_2
k59_676239_2	96561.Dole_2512	6.45e-29	109.0	COG3086@1|root,COG3086@2|Bacteria,1PKXC@1224|Proteobacteria,42UU9@68525|delta/epsilon subdivisions,2WPMZ@28221|Deltaproteobacteria,2MK8X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
k59_217895_1	395494.Galf_2734	6.39e-22	98.2	COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,44V77@713636|Nitrosomonadales	28216|Betaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
k59_741441_1	298655.KI912266_gene673	1.91e-74	237.0	COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria,4EUJC@85013|Frankiales	201174|Actinobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_512737_1	358396.C445_03398	7.31e-31	125.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,23SB7@183963|Halobacteria	28890|Euryarchaeota	C	COG1042 Acyl-CoA synthetase (NDP forming)	acdAB	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_839585_1	1163617.SCD_n00054	1.18e-37	134.0	COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria,2VU54@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
k59_839585_2	349102.Rsph17025_3135	8.99e-19	86.3	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,1FAPS@1060|Rhodobacter	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_475636_1	926569.ANT_04400	3.95e-43	154.0	COG0454@1|root,COG1247@1|root,COG0456@2|Bacteria,COG1247@2|Bacteria,2G6N6@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_247331_1	1415756.JQMY01000001_gene2981	4.25e-06	51.6	2CQ1K@1|root,32SKA@2|Bacteria,1N0TP@1224|Proteobacteria,2U7ZA@28211|Alphaproteobacteria,2PEMX@252301|Oceanicola	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
k59_380616_1	1121946.AUAX01000020_gene3059	5.12e-30	120.0	COG5297@1|root,COG5297@2|Bacteria,2HDPZ@201174|Actinobacteria,4DCXB@85008|Micromonosporales	201174|Actinobacteria	G	Glycosyl hydrolase family 12	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Glyco_hydro_12
k59_120640_1	996637.SGM_2355	4.58e-43	152.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_314558_1	76114.ebA1196	5.91e-62	197.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,2KUIS@206389|Rhodocyclales	206389|Rhodocyclales	P	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_185393_1	1232683.ADIMK_0681	1.52e-83	263.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	Glutaredoxin,PALP
k59_709059_1	768671.ThimaDRAFT_0912	9.31e-70	228.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,1RQ8F@1236|Gammaproteobacteria,1X14E@135613|Chromatiales	135613|Chromatiales	P	Periplasmic copper-binding protein (NosD)	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
k59_642508_1	742159.HMPREF0004_5500	5.14e-75	233.0	COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2VI3C@28216|Betaproteobacteria,3T5DP@506|Alcaligenaceae	28216|Betaproteobacteria	S	hydrolases of the HAD superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_54771_1	1121405.dsmv_0564	6.98e-82	271.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_610189_2	1123247.AUIJ01000011_gene607	4.01e-28	109.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	MA20_44635	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_870880_1	640081.Dsui_2455	9.73e-99	300.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KUVY@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the peptidase S1C family	degQ	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_22956_1	1449065.JMLL01000013_gene2716	3.4e-47	164.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,43ICY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_54778_1	748247.AZKH_2645	7.63e-48	166.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,2KVQY@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome bd-type quinol oxidase, subunit 1	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_185409_1	330214.NIDE0295	4.01e-92	281.0	COG1206@1|root,COG1206@2|Bacteria,3J0WT@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
k59_54784_1	396588.Tgr7_2580	4.1e-14	72.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,1RMEB@1236|Gammaproteobacteria,1WVW5@135613|Chromatiales	135613|Chromatiales	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	-	-	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
k59_54784_3	83406.HDN1F_12780	2.34e-09	58.2	COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,1RMGX@1236|Gammaproteobacteria,1J6C4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferase family 21	mdoH	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006073,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009628,GO:0009987,GO:0016020,GO:0016021,GO:0016051,GO:0016740,GO:0016757,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:1901576	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glyco_trans_2_3,Glycos_transf_2
k59_676296_1	1265502.KB905959_gene278	1.24e-81	253.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,4AAD0@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_709088_1	351627.Csac_1164	1.32e-11	67.8	COG0646@1|root,COG0646@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,42FHS@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
k59_902520_1	1396141.BATP01000018_gene1562	7.17e-53	175.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	cccE	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_22976_1	1123508.JH636443_gene5029	9.97e-108	321.0	COG0451@1|root,COG0451@2|Bacteria,2J25C@203682|Planctomycetes	203682|Planctomycetes	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_54797_1	639283.Snov_1607	6.37e-46	162.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria,3EZS5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_676310_1	1370122.JHXQ01000002_gene2852	2.2e-90	273.0	COG3385@1|root,COG3385@2|Bacteria,1R8M9@1224|Proteobacteria,2UI32@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_348849_2	945713.IALB_3168	1.13e-55	177.0	COG2872@1|root,COG2872@2|Bacteria	2|Bacteria	S	Ser-tRNA(Ala) hydrolase activity	amyA	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,tRNA_SAD
k59_839649_1	1121946.AUAX01000016_gene4671	8.64e-58	189.0	COG0667@1|root,COG0667@2|Bacteria,2GJ6R@201174|Actinobacteria,4DBPI@85008|Micromonosporales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
k59_642551_1	330214.NIDE0499	6.3e-24	94.4	COG4696@1|root,COG4696@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	XK27_03185	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	Acetyltransf_3,Hydrolase_3,PRA-PH
k59_217960_1	767817.Desgi_0419	8.33e-57	198.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_153361_1	272624.lpg2184	3.11e-52	181.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,1S0CA@1236|Gammaproteobacteria,1JE4B@118969|Legionellales	118969|Legionellales	L	Transposase DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind
k59_153361_2	237368.SCABRO_00493	1.11e-40	154.0	COG3385@1|root,COG3385@2|Bacteria,2IZKA@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase Tn5 dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimer_Tnp_Tn5,Tnp_DNA_bind
k59_741529_1	497321.C664_18032	7.08e-56	176.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,2KWTI@206389|Rhodocyclales	206389|Rhodocyclales	T	response regulator receiver	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_741529_2	666681.M301_1638	3.27e-47	155.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,2KMW5@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM response regulator receiver	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_453089_1	402881.Plav_1709	7.29e-46	166.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Mate efflux family protein	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_321202_2	1146883.BLASA_2784	7.56e-24	104.0	COG0458@1|root,COG0458@2|Bacteria,2GKXY@201174|Actinobacteria	201174|Actinobacteria	EF	Pfam Carbamoyl-phosphate synthase L chain, ATP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4,CPSase_L_D2
k59_192614_1	1449126.JQKL01000079_gene3093	4.86e-49	162.0	COG3663@1|root,COG3663@2|Bacteria,1V3X9@1239|Firmicutes,24EFB@186801|Clostridia	186801|Clostridia	L	glycosylase superfamily	-	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_61837_1	945713.IALB_1511	4.77e-68	223.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_161497_1	85643.Tmz1t_3041	1.95e-216	625.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,2KV41@206389|Rhodocyclales	206389|Rhodocyclales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_282204_1	1454004.AW11_00344	1.35e-81	265.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,1KQ6G@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF3394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_482877_1	767817.Desgi_3732	1.43e-31	117.0	COG3383@1|root,COG3383@2|Bacteria,1V1Y2@1239|Firmicutes,24FSX@186801|Clostridia,264TA@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.17.1.9,1.6.5.3	ko:K00123,ko:K00336	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_21,NADH-G_4Fe-4S_3
k59_482877_2	1121405.dsmv_1967	1.28e-31	123.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MMTC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K05587,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_62837_2	85643.Tmz1t_1282	3.62e-39	138.0	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria,2KX1A@206389|Rhodocyclales	206389|Rhodocyclales	S	FixH family	-	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
k59_418099_1	330214.NIDE0826	2.55e-54	176.0	COG0226@1|root,COG0226@2|Bacteria,3J0YH@40117|Nitrospirae	2|Bacteria	P	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	forD	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	CO_dh,PBP_like_2
k59_418099_2	330214.NIDE0827	7.49e-20	88.2	COG0674@1|root,COG0674@2|Bacteria,3J105@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_225999_1	76114.ebA6506	7.25e-56	191.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,2KUFZ@206389|Rhodocyclales	206389|Rhodocyclales	C	COG1960 Acyl-CoA dehydrogenases	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_910520_1	1211815.CBYP010000028_gene1034	3.47e-24	100.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4ESD1@85013|Frankiales	201174|Actinobacteria	G	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_910520_2	1121921.KB898709_gene86	8.36e-13	69.7	COG0477@1|root,COG2814@2|Bacteria,1MVKJ@1224|Proteobacteria,1RMHJ@1236|Gammaproteobacteria,2PNA1@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K05548	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,Sugar_tr
k59_586890_1	1131266.ARWQ01000005_gene828	1.41e-91	273.0	COG3253@1|root,arCOG03031@2157|Archaea,41SGX@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
k59_161520_1	864051.BurJ1DRAFT_1083	8.47e-79	239.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJ0Q@28216|Betaproteobacteria,1KJHD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_161520_2	987059.RBXJA2T_14356	2.47e-15	73.9	COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2VIID@28216|Betaproteobacteria,1KJQG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_685020_1	745310.G432_06615	1.45e-136	394.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria,2K3KK@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_685020_2	13690.CP98_00619	1.34e-96	289.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria,2K3KK@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_521532_1	1123060.JONP01000009_gene2080	2.28e-35	127.0	COG1546@1|root,COG1546@2|Bacteria,1RHXH@1224|Proteobacteria,2UACN@28211|Alphaproteobacteria,2JWT0@204441|Rhodospirillales	204441|Rhodospirillales	S	Competence-damaged protein	-	-	-	-	-	-	-	-	-	-	-	-	CinA
k59_357266_2	1380394.JADL01000033_gene4100	1.6e-34	132.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2JS2T@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_97061_1	69042.WH5701_06631	5.25e-48	167.0	COG1373@1|root,COG1373@2|Bacteria,1GRNG@1117|Cyanobacteria,1H2G8@1129|Synechococcus	1117|Cyanobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
k59_31321_1	1123284.KB899047_gene1766	1.55e-29	119.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,4HBPD@91061|Bacilli,26PTD@186821|Sporolactobacillaceae	91061|Bacilli	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_650728_1	1122604.JONR01000015_gene107	2.48e-20	95.5	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XD55@135614|Xanthomonadales	135614|Xanthomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
k59_129054_1	314264.ROS217_10757	2.69e-60	191.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U4QB@28211|Alphaproteobacteria,46NZH@74030|Roseovarius	28211|Alphaproteobacteria	Q	COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_129054_2	1304877.KI519399_gene2906	5.46e-96	291.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,3JWB9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
k59_717651_1	1229909.NSED_09450	1.05e-51	170.0	COG0347@1|root,arCOG02305@2157|Archaea	2157|Archaea	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_717651_2	436308.Nmar_0587	6.16e-45	148.0	COG0347@1|root,arCOG02305@2157|Archaea	2157|Archaea	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF2226,P-II
k59_717651_3	1229909.NSED_09440	2.44e-44	155.0	COG0004@1|root,arCOG04397@2157|Archaea,41SZ0@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_454111_1	330214.NIDE3327	4.39e-49	158.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_650729_1	395495.Lcho_2228	1.03e-102	309.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,1KJ7S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
k59_521541_1	1297863.APJF01000019_gene2436	1.79e-58	191.0	COG2084@1|root,COG2084@2|Bacteria,1MWR4@1224|Proteobacteria,2U157@28211|Alphaproteobacteria,3JRTW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_618460_2	330214.NIDE1351	3.68e-58	189.0	COG3168@1|root,COG3168@2|Bacteria,3J1AT@40117|Nitrospirae	40117|Nitrospirae	NU	Pilus assembly protein, PilP	-	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_978726_1	679926.Mpet_2814	1.81e-14	75.1	arCOG01792@1|root,arCOG01792@2157|Archaea,2XSXC@28890|Euryarchaeota,2N9K5@224756|Methanomicrobia	224756|Methanomicrobia	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_978726_2	1231391.AMZF01000008_gene1618	8.23e-18	80.9	COG2259@1|root,COG2259@2|Bacteria,1RCKY@1224|Proteobacteria,2WBHC@28216|Betaproteobacteria,3T875@506|Alcaligenaceae	28216|Betaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_254790_1	1392838.AWNM01000064_gene4169	1.86e-15	75.9	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2VIXA@28216|Betaproteobacteria,3T32V@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type amino acid transport system permease component	aapM	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_254790_2	426117.M446_5873	4.68e-53	174.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,1JR7I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM ABC transporter	aapP	-	3.6.3.21	ko:K02028,ko:K09972,ko:K10004	ko02010,ko02020,map02010,map02020	M00230,M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.19,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
k59_161532_1	28258.KP05_04170	2.06e-20	94.4	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1XHA2@135619|Oceanospirillales	135619|Oceanospirillales	U	type II secretion system protein	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_650738_1	330214.NIDE4175	3.67e-76	234.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
k59_322195_1	1249997.JHZW01000002_gene1599	3.7e-17	85.9	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,1HY3A@117743|Flavobacteriia,2PG0A@252356|Maribacter	976|Bacteroidetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	dpp	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_1027340_1	33876.JNXY01000028_gene3356	2.99e-15	80.9	COG2303@1|root,COG4757@1|root,COG2303@2|Bacteria,COG4757@2|Bacteria,2GNHC@201174|Actinobacteria,4DC50@85008|Micromonosporales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.1.400	ko:K20927,ko:K21166	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_848423_1	347834.RHE_CH00946	4.02e-103	310.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,4BBCA@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1009241_1	1453500.AT05_05490	1.42e-43	152.0	COG2010@1|root,COG2010@2|Bacteria,4NFMJ@976|Bacteroidetes,1HZ3Y@117743|Flavobacteriia	976|Bacteroidetes	C	cytochrome C	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
k59_879074_1	1122134.KB893651_gene1787	7.15e-71	215.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,1XJIX@135619|Oceanospirillales	135619|Oceanospirillales	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_879074_2	887062.HGR_09099	2.55e-05	44.3	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,4AEBZ@80864|Comamonadaceae	28216|Betaproteobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_193716_1	98439.AJLL01000033_gene3374	1.4e-59	200.0	COG3540@1|root,COG3540@2|Bacteria,1G0C9@1117|Cyanobacteria,1JKIQ@1189|Stigonemataceae	1117|Cyanobacteria	P	PhoD-like phosphatase, N-terminal domain	phoD	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
k59_879075_1	713586.KB900536_gene606	1.08e-83	254.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1WW93@135613|Chromatiales	135613|Chromatiales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_161546_1	314287.GB2207_02047	7.19e-38	138.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1J5VS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I	yycJ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_945961_1	1177154.Y5S_01265	2.47e-07	52.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,1S21F@1236|Gammaproteobacteria,1XJVG@135619|Oceanospirillales	135619|Oceanospirillales	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
k59_945961_2	1121405.dsmv_0647	2.85e-64	209.0	COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria,2MJCH@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_226043_1	591019.Shell_0539	1.56e-23	102.0	COG0436@1|root,arCOG01130@2157|Archaea,2XPZW@28889|Crenarchaeota	28889|Crenarchaeota	E	aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1027341_2	1121033.AUCF01000011_gene1768	4.24e-150	435.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,2JQVK@204441|Rhodospirillales	204441|Rhodospirillales	S	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_750324_1	1123487.KB892864_gene2095	9.58e-32	117.0	2E74N@1|root,331P2@2|Bacteria,1RC0J@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_618493_1	436308.Nmar_0444	4.7e-112	342.0	COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_879099_1	1123277.KB893179_gene3151	2.96e-73	223.0	COG2080@1|root,COG2080@2|Bacteria,4NM72@976|Bacteroidetes,47XN3@768503|Cytophagia	976|Bacteroidetes	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_454156_1	639030.JHVA01000001_gene3144	3.09e-10	66.2	COG0312@1|root,COG0312@2|Bacteria,3Y39N@57723|Acidobacteria,2JIHC@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_482947_1	436308.Nmar_1313	7.38e-66	202.0	COG0640@1|root,arCOG00731@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_357328_1	1042326.AZNV01000061_gene4596	4.37e-87	288.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4BBZJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9
k59_586959_1	28258.KP05_07930	5.1e-08	53.9	COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1XHUS@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the BCCT transporter (TC 2.A.15) family	-	-	-	ko:K03451	-	-	-	-	ko00000	2.A.15	-	-	BCCT
k59_521611_1	670307.HYPDE_37343	1.52e-08	55.5	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_521611_2	330214.NIDE3475	4.83e-144	420.0	COG0845@1|root,COG0845@2|Bacteria,3J10X@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_388650_1	2340.JV46_26690	1.07e-70	220.0	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_717717_1	153948.NAL212_2194	1.05e-44	149.0	COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,373B0@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_717717_2	243233.MCA0095	7.46e-10	58.5	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEV2@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_750354_1	1122947.FR7_1058	5.25e-75	234.0	COG3332@1|root,COG3332@2|Bacteria,1UYHE@1239|Firmicutes,4H7AN@909932|Negativicutes	909932|Negativicutes	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
k59_254856_1	3067.XP_002948592.1	0.000368	42.4	COG0492@1|root,COG0526@1|root,KOG0404@2759|Eukaryota,KOG0907@2759|Eukaryota,37IAU@33090|Viridiplantae,34GWR@3041|Chlorophyta	3041|Chlorophyta	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Thioredoxin
k59_254856_2	574966.KB898652_gene1814	3.05e-18	85.1	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1XI6J@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_97139_1	580332.Slit_2143	2.79e-73	233.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,44VJQ@713636|Nitrosomonadales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	lplT	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_491734_1	247634.GPB2148_1965	3.15e-79	253.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1J52J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_393448_1	481448.Minf_0852	9.69e-40	149.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,TraG-D_C,TrwB_AAD_bind
k59_916159_1	323848.Nmul_A2541	2.34e-92	281.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,37280@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_589563_2	261292.Nit79A3_0023	1.8e-49	163.0	COG2010@1|root,COG2010@2|Bacteria,1RGXM@1224|Proteobacteria,2VUPT@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_981135_1	1000565.METUNv1_02663	7.69e-21	88.2	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,2KU7Q@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_981135_2	261292.Nit79A3_2470	2.04e-89	272.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,372AR@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_132510_1	1175306.GWL_17290	1.99e-24	96.3	COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,474JP@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	transporter component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_132510_2	1178482.BJB45_16670	2.75e-55	177.0	COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,1S8UB@1236|Gammaproteobacteria,1XKP8@135619|Oceanospirillales	135619|Oceanospirillales	S	Transporter Component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_720133_1	1205680.CAKO01000002_gene2788	1.22e-68	223.0	COG1058@1|root,COG1058@2|Bacteria,1QUB2@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the CinA family	yfaY	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_1786_1	479433.Caci_4007	3.54e-13	75.1	COG3344@1|root,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria	201174|Actinobacteria	L	RNA-directed DNA polymerase (reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_752436_1	706587.Desti_4721	5.93e-29	106.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_197823_2	234267.Acid_3938	6.42e-30	118.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
k59_67250_1	1045855.DSC_02785	2.6e-07	52.8	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1X30V@135614|Xanthomonadales	135614|Xanthomonadales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_361800_1	1267535.KB906767_gene5039	4.08e-33	131.0	COG0520@1|root,COG0520@2|Bacteria,3Y632@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_231106_1	1454004.AW11_02451	6.21e-63	218.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_9,Response_reg
k59_590582_1	365046.Rta_21540	7.58e-25	102.0	COG1052@1|root,COG1052@2|Bacteria,1MVSS@1224|Proteobacteria,2VN5N@28216|Betaproteobacteria,4AGX2@80864|Comamonadaceae	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_427163_1	1255043.TVNIR_1131	2.88e-92	285.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales	135613|Chromatiales	L	PFAM Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_917227_1	398767.Glov_3450	5.34e-77	242.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,43VCE@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_525284_1	177439.DP1142	5.24e-71	218.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_525284_2	1265505.ATUG01000001_gene3695	3.6e-06	45.4	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2WQ8U@28221|Deltaproteobacteria,2MKF7@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_949609_2	1229909.NSED_01460	1.65e-33	117.0	arCOG08822@1|root,arCOG08822@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_296562_1	1268622.AVS7_00501	2.47e-10	61.2	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,4AAI5@80864|Comamonadaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_296562_2	420662.Mpe_A1415	3.42e-102	310.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,1KK0V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_133583_1	497321.C664_03000	9.4e-76	236.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2VI7V@28216|Betaproteobacteria,2KUCX@206389|Rhodocyclales	206389|Rhodocyclales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_525292_1	1232410.KI421413_gene599	4.2e-114	350.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2WKBA@28221|Deltaproteobacteria,43TAY@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_166167_1	398767.Glov_1886	3.57e-07	57.4	COG0500@1|root,COG2835@1|root,COG2226@2|Bacteria,COG2835@2|Bacteria,1R5RG@1224|Proteobacteria,42NHW@68525|delta/epsilon subdivisions,2WKI8@28221|Deltaproteobacteria,43TKH@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Trm112p
k59_231122_1	342113.DM82_6228	1.08e-59	211.0	COG0842@1|root,COG1129@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,1K1JP@119060|Burkholderiaceae	28216|Betaproteobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_tran
k59_688701_1	1118060.CAGZ01000027_gene1011	3.42e-23	96.7	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4CUM5@84998|Coriobacteriia	84998|Coriobacteriia	L	Uracil-DNA glycosylase, family 4	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_688701_2	1382304.JNIL01000001_gene677	7.16e-07	50.8	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4HAK8@91061|Bacilli,277Z1@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_656016_2	76114.ebA6730	4.17e-75	234.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2W0ZB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_35637_1	330214.NIDE3970	2.5e-98	293.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	VVA0018	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
k59_166175_1	1095769.CAHF01000018_gene821	1.36e-55	192.0	COG4664@1|root,COG4665@1|root,COG4664@2|Bacteria,COG4665@2|Bacteria,1R4MZ@1224|Proteobacteria,2VJ2Q@28216|Betaproteobacteria,47290@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_166175_2	883078.HMPREF9695_04701	4.67e-22	94.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,3JWB9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
k59_819329_1	436308.Nmar_0616	3.8e-68	233.0	arCOG08231@1|root,arCOG08231@2157|Archaea,41T6Q@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	LTD
k59_982039_1	314265.R2601_08011	8.77e-33	114.0	COG0004@1|root,COG0004@2|Bacteria,1MX44@1224|Proteobacteria,2TR55@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0004 Ammonia permease	-	-	-	-	-	-	-	-	-	-	-	-	Ammonium_transp
k59_917269_1	929556.Solca_4206	2.64e-21	96.7	COG0845@1|root,COG0845@2|Bacteria,4NIDC@976|Bacteroidetes,1INTJ@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_819339_1	86416.Clopa_1038	7.61e-48	162.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,36EGD@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_819339_2	84531.JMTZ01000007_gene3447	5.52e-13	69.3	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1X3HB@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_68386_1	1120983.KB894573_gene126	2.89e-55	192.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,1JNSZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K04116	ko00362,ko01120,map00362,map01120	M00540	R05620	RC00004,RC01438	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_133610_1	765914.ThisiDRAFT_0750	7.44e-71	224.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1WXGN@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_133610_2	765913.ThidrDRAFT_4577	5.81e-25	104.0	COG3385@1|root,COG5433@1|root,COG3385@2|Bacteria,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1WWWX@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_133610_3	765911.Thivi_1197	1.14e-29	114.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1WXGN@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_884079_1	420324.KI912090_gene7154	3.22e-75	238.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,1JQXW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	peptidase dimerisation domain	MA20_09240	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_35667_1	264462.Bd1660	1.47e-57	186.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2MUNZ@213481|Bdellovibrionales,2WJKH@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_851612_1	268739.Nmlp_2934	8.49e-13	71.2	COG3547@1|root,arCOG03585@2157|Archaea,2XWFH@28890|Euryarchaeota,23TAM@183963|Halobacteria	183963|Halobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_558110_1	1068980.ARVW01000001_gene654	7.21e-23	102.0	COG1878@1|root,COG1878@2|Bacteria,2GQ54@201174|Actinobacteria	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_492863_1	35128.Thaps22864	4.5e-14	77.8	COG0404@1|root,KOG2844@2759|Eukaryota,2XE3A@2836|Bacillariophyta	2836|Bacillariophyta	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_558117_1	697282.Mettu_0567	6.97e-82	261.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1XE30@135618|Methylococcales	1236|Gammaproteobacteria	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	treZ	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_198880_1	887898.HMPREF0551_1888	9.7e-51	165.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2VRAK@28216|Betaproteobacteria,1K75Y@119060|Burkholderiaceae	28216|Betaproteobacteria	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_198880_2	85643.Tmz1t_3320	1.76e-21	85.5	COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,2VVPT@28216|Betaproteobacteria,2KX85@206389|Rhodocyclales	206389|Rhodocyclales	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_198880_3	323848.Nmul_A0784	2.55e-85	255.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2VQ80@28216|Betaproteobacteria,3723A@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_198880_4	999541.bgla_1g03190	3.19e-40	137.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,1K7WM@119060|Burkholderiaceae	28216|Betaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_819360_1	1123393.KB891326_gene217	5.4e-86	268.0	COG0294@1|root,COG0294@2|Bacteria,1MWM3@1224|Proteobacteria,2VH38@28216|Betaproteobacteria,1KSHT@119069|Hydrogenophilales	119069|Hydrogenophilales	H	dihydropteroate synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_427231_1	1121413.JMKT01000012_gene598	1.19e-17	85.5	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria,2M7YA@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_231174_1	1121939.L861_22300	1.91e-60	192.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1SZU4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_525350_1	1379698.RBG1_1C00001G0278	2.6e-65	221.0	COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_100939_1	1121033.AUCF01000021_gene2817	0.000304	43.5	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2TWCZ@28211|Alphaproteobacteria,2JYV3@204441|Rhodospirillales	204441|Rhodospirillales	CI	phosphate acetyltransferase	-	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_100939_2	1446473.JHWH01000001_gene1109	5.24e-14	74.7	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2TQQQ@28211|Alphaproteobacteria,2PWFE@265|Paracoccus	28211|Alphaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_427241_1	886293.Sinac_4454	5.8e-45	167.0	COG0642@1|root,COG0745@1|root,COG2203@1|root,COG3829@1|root,COG3852@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,2IX8Z@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,Response_reg
k59_525359_1	864051.BurJ1DRAFT_1073	1.8e-100	299.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria,1KK7U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_361889_1	706587.Desti_4173	4.2e-41	149.0	COG1215@1|root,COG1215@2|Bacteria,1QVA1@1224|Proteobacteria,43BP8@68525|delta/epsilon subdivisions,2X70I@28221|Deltaproteobacteria,2MSKJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
k59_982092_1	436308.Nmar_0352	1.43e-51	164.0	COG1911@1|root,arCOG01752@2157|Archaea,41SW9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	PFAM ribosomal protein L7Ae L30e S12e Gadd45	-	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
k59_459667_1	1121035.AUCH01000001_gene2094	5.76e-86	273.0	COG0128@1|root,COG0283@1|root,COG0128@2|Bacteria,COG0283@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,2KUWK@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	cmk	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
k59_100964_2	765912.Thimo_0823	1.35e-27	114.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWGD@135613|Chromatiales	135613|Chromatiales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_851654_1	1278073.MYSTI_00409	1.19e-115	342.0	2C1VH@1|root,2Z7Z3@2|Bacteria,1MY5B@1224|Proteobacteria	1224|Proteobacteria	S	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase	wbxY	-	-	-	-	-	-	-	-	-	-	-	Kdo_hydroxy
k59_459673_1	702113.PP1Y_Mpl3410	4.81e-06	50.1	2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,2U39W@28211|Alphaproteobacteria,2K12X@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_459673_2	502025.Hoch_5019	1.03e-49	172.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2YU57@29|Myxococcales	28221|Deltaproteobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_264251_1	391625.PPSIR1_28278	3.02e-69	218.0	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,42R9G@68525|delta/epsilon subdivisions,2WMTN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
k59_525380_1	1158345.JNLL01000001_gene1761	7.06e-20	89.4	COG4992@1|root,COG4992@2|Bacteria,2G3V4@200783|Aquificae	200783|Aquificae	E	acetylornithine and succinylornithine aminotransferase	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_525380_2	751994.AGIG01000028_gene1972	9.99e-32	120.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1J5E4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0033554,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00930,ko:K22478	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2508,iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iUTI89_1310.UTI89_C4550,iY75_1357.Y75_RS17255	AA_kinase,NAT
k59_590693_1	710685.MycrhN_1022	1.05e-05	50.8	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,239R6@1762|Mycobacteriaceae	201174|Actinobacteria	L	PFAM Integrase, catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,LZ_Tnp_IS481,rve,rve_3
k59_525381_1	382464.ABSI01000013_gene1570	1.63e-23	101.0	COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,46U27@74201|Verrucomicrobia	74201|Verrucomicrobia	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
k59_2955_1	1454004.AW11_02850	6.44e-23	92.0	COG1320@1|root,COG1320@2|Bacteria	2|Bacteria	P	monovalent cation:proton antiporter activity	mnhG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_2955_2	1454004.AW11_02849	7.87e-33	116.0	COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria	1224|Proteobacteria	P	Multiple resistance and pH regulation protein F	mnhF	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_133664_1	640081.Dsui_1159	6.42e-101	302.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2VHKM@28216|Betaproteobacteria,2KVMG@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the HypD family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_394433_1	439235.Dalk_3639	1.15e-57	194.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_141288_1	1191523.MROS_2413	4.07e-33	124.0	2CG1Y@1|root,2Z9QX@2|Bacteria	2|Bacteria	S	COG NOG19146 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
k59_630779_1	592015.HMPREF1705_00061	0.00045	46.2	COG1434@1|root,COG1434@2|Bacteria,3TB97@508458|Synergistetes	508458|Synergistetes	S	PFAM DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
k59_400567_1	34007.IT40_09370	7.05e-25	103.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,cNMP_binding
k59_663909_1	62928.azo2862	2.11e-11	63.5	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KW6R@206389|Rhodocyclales	206389|Rhodocyclales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_663909_2	1095769.CAHF01000011_gene2300	2.1e-79	244.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2W98D@28216|Betaproteobacteria,476N1@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_207167_2	316067.Geob_1766	2.38e-30	118.0	2DRUI@1|root,33D4D@2|Bacteria,1NKUT@1224|Proteobacteria,43338@68525|delta/epsilon subdivisions,2WXDX@28221|Deltaproteobacteria,43VRS@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_109553_1	1005999.GLGR_3445	1.41e-74	238.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the GARS family	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01945,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729	GARS_A,GARS_C,GARS_N
k59_44146_1	671143.DAMO_0676	1.15e-40	150.0	COG0815@1|root,COG0815@2|Bacteria,2NP0R@2323|unclassified Bacteria	2|Bacteria	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_11817_2	1121033.AUCF01000001_gene2030	1.39e-76	244.0	COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,2U66Q@28211|Alphaproteobacteria,2JRZ1@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_859931_1	365044.Pnap_1452	1.54e-39	139.0	COG3572@1|root,COG3572@2|Bacteria,1N0R0@1224|Proteobacteria,2VUCP@28216|Betaproteobacteria,4AEYP@80864|Comamonadaceae	28216|Betaproteobacteria	H	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
k59_859931_2	159087.Daro_0494	2.47e-18	84.7	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2VI47@28216|Betaproteobacteria,2KVBH@206389|Rhodocyclales	206389|Rhodocyclales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
k59_238029_1	1384054.N790_02555	3.61e-15	77.4	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1X347@135614|Xanthomonadales	135614|Xanthomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_501647_1	614083.AWQR01000005_gene1161	1.33e-51	169.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,4ABJC@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	aapP	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
k59_501647_2	1100720.ALKN01000031_gene1259	6.98e-35	128.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2VIXA@28216|Betaproteobacteria,4ABBP@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	aapM	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_958529_1	395494.Galf_2009	2.51e-59	197.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,44VDT@713636|Nitrosomonadales	28216|Betaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	aoxR	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_859938_2	583345.Mmol_1581	1.32e-51	167.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2VSDF@28216|Betaproteobacteria,2KMY6@206350|Nitrosomonadales	206350|Nitrosomonadales	K	PFAM regulatory protein MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_466463_1	991905.SL003B_3035	3.78e-111	331.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria,4BRM2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3039 Transposase and inactivated derivatives, IS5 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_859940_1	261292.Nit79A3_2824	3.28e-106	326.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,371Q6@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_529945_1	1079460.ATTQ01000013_gene2729	1.24e-110	332.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4BABY@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	MA20_08220	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_926026_2	1345697.M493_11730	1.87e-36	135.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,4HA7D@91061|Bacilli,1WG0Q@129337|Geobacillus	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	resD	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_958546_1	113395.AXAI01000002_gene5219	9.73e-28	116.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_272197_1	13689.BV96_03171	2.19e-50	164.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,2K0CZ@204457|Sphingomonadales	204457|Sphingomonadales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_787305_1	1485544.JQKP01000003_gene129	2.01e-46	164.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,44V44@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_664864_1	644968.DFW101_1527	3.05e-24	105.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2M8ID@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_109592_1	1229909.NSED_09150	4.09e-67	213.0	COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota	651137|Thaumarchaeota	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
k59_109592_2	436308.Nmar_1717	3.21e-21	90.5	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
k59_859953_1	1123261.AXDW01000009_gene95	5.06e-123	362.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1X4BJ@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_370229_1	497965.Cyan7822_2659	2.32e-18	95.1	COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,3KH7P@43988|Cyanothece	1117|Cyanobacteria	T	Multi-sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4
k59_304573_1	1415778.JQMM01000001_gene2046	8.13e-81	266.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_304573_2	1255043.TVNIR_1418	1.82e-07	50.1	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales	135613|Chromatiales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_435473_1	1040987.AZUY01000052_gene2791	2.53e-37	137.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome c peroxidase	ccpA	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_77251_1	102129.Lepto7375DRAFT_0655	1.29e-21	97.4	COG4403@1|root,COG4403@2|Bacteria,1G1PI@1117|Cyanobacteria,1H9Z7@1150|Oscillatoriales	1117|Cyanobacteria	V	Lanthionine synthetase C family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_466487_1	394.NGR_c08400	3.38e-15	75.1	COG3832@1|root,COG3832@2|Bacteria,1RDTP@1224|Proteobacteria,2U795@28211|Alphaproteobacteria,4BA3Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_304578_1	159450.NH14_08630	6.24e-24	104.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2VPCI@28216|Betaproteobacteria,1K11U@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_29,rve
k59_370236_1	1090319.KE386571_gene1013	6.3e-124	373.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2K0SB@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_370236_2	1005048.CFU_0372	9.86e-64	210.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,472BG@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3
k59_760276_1	675814.VIC_003803	3.5e-59	193.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,1RMBA@1236|Gammaproteobacteria,1XUR9@135623|Vibrionales	135623|Vibrionales	E	COG0620 Methionine synthase II (cobalamin-independent)	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_760276_2	1038859.AXAU01000001_gene3649	2.8e-74	239.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3JTY7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_466495_2	472759.Nhal_0244	7.05e-08	52.4	2E5P1@1|root,330DP@2|Bacteria,1N794@1224|Proteobacteria,1SD5J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
k59_529968_1	1116472.MGMO_37c00220	3.04e-75	251.0	COG2132@1|root,COG2132@2|Bacteria,1QZ1I@1224|Proteobacteria,1S18S@1236|Gammaproteobacteria,1XEXE@135618|Methylococcales	1236|Gammaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22350	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2
k59_892216_1	261292.Nit79A3_0235	6.33e-146	421.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,371PD@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_304593_2	580332.Slit_0531	6.98e-102	305.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,44W64@713636|Nitrosomonadales	28216|Betaproteobacteria	T	SMART protein phosphatase 2C domain protein	pppL	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_304593_3	85643.Tmz1t_0921	4.56e-27	105.0	COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria,2KUV6@206389|Rhodocyclales	206389|Rhodocyclales	T	(FHA) domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
k59_238084_1	492774.JQMB01000005_gene5489	1.6e-12	67.4	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,4B7JW@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_238084_2	391600.ABRU01000010_gene3165	2.74e-25	102.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,2KG9F@204458|Caulobacterales	204458|Caulobacterales	S	ICC-like phosphoesterases	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
k59_859989_1	913325.N799_03360	2.47e-16	77.8	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1X2XF@135614|Xanthomonadales	135614|Xanthomonadales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_859989_2	1125863.JAFN01000001_gene102	1.96e-34	131.0	COG3005@1|root,COG3005@2|Bacteria,1R8V7@1224|Proteobacteria,42YES@68525|delta/epsilon subdivisions,2WU80@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_958584_1	436308.Nmar_0188	5.14e-91	269.0	COG4276@1|root,arCOG04604@2157|Archaea,41SI9@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_828217_1	1037409.BJ6T_88610	5.29e-124	379.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2TVA2@28211|Alphaproteobacteria,3JRH7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4_2,rve
k59_828217_2	75379.Tint_1559	2.75e-13	69.3	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2VMVE@28216|Betaproteobacteria,1KMMP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
k59_599326_1	493475.GARC_2352	2.09e-69	236.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mtrD_1	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_304603_1	391603.FBALC1_06163	3.31e-91	278.0	COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,1HXA1@117743|Flavobacteriia	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_566876_1	760192.Halhy_1898	2.01e-15	71.6	COG3350@1|root,COG3350@2|Bacteria,4PK14@976|Bacteroidetes,1IZ1G@117747|Sphingobacteriia	976|Bacteroidetes	S	monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_566876_2	1121924.ATWH01000007_gene2181	6.52e-36	131.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,DLH,Hydrolase_4
k59_631715_1	436308.Nmar_0090	7.67e-115	336.0	COG1131@1|root,arCOG00194@2157|Archaea,41TB8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_926091_1	1303518.CCALI_02721	1.2e-18	85.9	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088,ko:K07263	-	-	-	-	ko00000,ko01000,ko01002,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_501739_1	987059.RBXJA2T_04438	3.8e-110	322.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VN3Q@28216|Betaproteobacteria,1KK3Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Electron transfer flavoprotein	fixA	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_370286_1	330214.NIDE3077	3.71e-107	328.0	COG0556@1|root,COG0556@2|Bacteria,3J0FS@40117|Nitrospirae	40117|Nitrospirae	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_174948_1	211165.AJLN01000101_gene4391	5.15e-28	123.0	COG4191@1|root,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1JJPK@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4
k59_238112_1	864051.BurJ1DRAFT_1346	2.67e-105	317.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,1KJXY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_990540_1	1278309.KB907101_gene394	3.33e-87	264.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,1XHXM@135619|Oceanospirillales	135619|Oceanospirillales	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
k59_664949_1	762966.HMPREF9439_02747	7.56e-45	149.0	COG3671@1|root,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria,4PR5N@995019|Sutterellaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_664949_2	880073.Calab_3610	9.27e-07	48.9	COG1047@1|root,COG1047@2|Bacteria,2NQ0G@2323|unclassified Bacteria	2|Bacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	slyD	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042026,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_860032_1	1384054.N790_05420	1.26e-68	225.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1X330@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_828265_1	420662.Mpe_A3214	1.57e-146	439.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,1KIWA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_338012_1	640081.Dsui_2410	5.47e-67	211.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VIX7@28216|Betaproteobacteria,2KU9Y@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_109680_1	1121937.AUHJ01000010_gene1752	5.88e-98	294.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,464Z9@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_401395_1	1163617.SCD_n00575	2.18e-38	135.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	abc transporter	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_401395_2	1163617.SCD_n00576	4.46e-141	404.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_401395_3	1217718.ALOU01000072_gene5031	2.65e-65	204.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,1K3MD@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	mlaD	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_599380_1	1286631.X805_10920	1.01e-06	48.5	2AZDN@1|root,31RM9@2|Bacteria,1QP4P@1224|Proteobacteria,2W9W2@28216|Betaproteobacteria,1KP13@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_599380_2	395495.Lcho_2535	1.92e-40	140.0	COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,2VRMP@28216|Betaproteobacteria,1KKT5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_238131_1	1335757.SPICUR_03555	1.47e-40	152.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1X14V@135613|Chromatiales	135613|Chromatiales	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_990563_1	1288494.EBAPG3_6750	7.04e-89	275.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,371T8@32003|Nitrosomonadales	28216|Betaproteobacteria	C	4Fe-4S double cluster binding domain	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
k59_990563_2	977880.RALTA_A2571	9.19e-22	94.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,1K1XC@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_238137_2	319795.Dgeo_2328	2.57e-60	199.0	COG0114@1|root,COG0114@2|Bacteria,1WJ9Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_338030_1	330214.NIDE4143	3.98e-65	214.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Spermine_synth
k59_935968_2	330214.NIDE0331	1.37e-40	137.0	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Methyltransf_25,Trm112p
k59_901254_1	933262.AXAM01000005_gene2537	3.78e-69	219.0	COG1344@1|root,COG1344@2|Bacteria,1MXC4@1224|Proteobacteria,42RME@68525|delta/epsilon subdivisions,2WN9Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	PFAM flagellin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Flagellin_C,Flagellin_N
k59_740163_1	1255043.TVNIR_2717	8.31e-17	75.9	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_740163_2	472759.Nhal_2803	5.54e-37	128.0	COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,1WZ3B@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF1820)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1820
k59_869595_1	622637.KE124773_gene4159	1.28e-39	134.0	COG3293@1|root,COG3293@2|Bacteria,1QXE6@1224|Proteobacteria,2TX8K@28211|Alphaproteobacteria,371IP@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
k59_869595_2	251221.35212193	9.24e-50	161.0	COG3293@1|root,COG3293@2|Bacteria,1G7GI@1117|Cyanobacteria	1117|Cyanobacteria	L	similarity to GB CAD86359.1	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_999975_1	502025.Hoch_3548	4.61e-106	325.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2YUHW@29|Myxococcales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_119356_1	1248760.ANFZ01000002_gene2996	1.65e-11	61.2	COG1359@1|root,COG1359@2|Bacteria,1N7AV@1224|Proteobacteria,2UIVG@28211|Alphaproteobacteria,2K7DX@204457|Sphingomonadales	204457|Sphingomonadales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_216701_2	1173028.ANKO01000195_gene5995	3.12e-32	126.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H8WC@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
k59_216701_3	1288494.EBAPG3_22130	2.35e-21	93.6	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,372E7@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Sigma-54 interaction domain	yfhA	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_838271_1	330214.NIDE0563	1.99e-238	665.0	COG1032@1|root,COG1032@2|Bacteria,3J0WM@40117|Nitrospirae	40117|Nitrospirae	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_707732_1	102125.Xen7305DRAFT_00028900	5.57e-05	49.3	COG4424@1|root,COG4424@2|Bacteria,1G7EI@1117|Cyanobacteria	1117|Cyanobacteria	S	Sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_838283_2	1041138.KB890233_gene2071	2.63e-43	155.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_740185_2	388051.AUFE01000005_gene1094	2.78e-80	245.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHZW@28216|Betaproteobacteria,1K11F@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_901273_2	338969.Rfer_0862	1.94e-60	190.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2VQ0V@28216|Betaproteobacteria,4AGUW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_21690_1	639030.JHVA01000001_gene2369	1.46e-18	90.9	COG1835@1|root,COG1835@2|Bacteria,3Y524@57723|Acidobacteria,2JJEN@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_184319_1	76114.ebA1212	6.82e-167	485.0	COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,2VH5K@28216|Betaproteobacteria,2KV8U@206389|Rhodocyclales	206389|Rhodocyclales	KLT	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	PP2C_2,Pkinase
k59_347559_1	522306.CAP2UW1_2360	5.92e-38	132.0	COG0454@1|root,COG0456@2|Bacteria,1QZ7S@1224|Proteobacteria,2WHVJ@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_347559_2	1122603.ATVI01000005_gene3150	2.42e-18	83.2	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1S24R@1236|Gammaproteobacteria,1X5Y6@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_313445_1	589865.DaAHT2_0826	2.98e-54	190.0	COG0685@1|root,COG2069@1|root,COG0685@2|Bacteria,COG2069@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,2MIIA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,MTHFR
k59_313445_2	264732.Moth_1192	4e-13	68.2	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,42FJ0@68295|Thermoanaerobacterales	186801|Clostridia	C	Methylene-tetrahydrofolate reductase C terminal	metV	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS18525	MTHFR_C
k59_740193_1	497321.C664_13499	6.76e-41	152.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,2KVPX@206389|Rhodocyclales	206389|Rhodocyclales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_379493_1	1395571.TMS3_0114760	1.1e-67	219.0	COG2203@1|root,COG2203@2|Bacteria,1PP8V@1224|Proteobacteria,1RYJ4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,Putative_PNPOx
k59_21702_1	1357423.S5MBW4_9CAUD	1.98e-29	117.0	4QAKE@10239|Viruses,4QUP7@35237|dsDNA viruses  no RNA stage	10239|Viruses	S	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_576770_1	323848.Nmul_A2067	1.25e-11	63.9	COG5416@1|root,COG5416@2|Bacteria,1N4UI@1224|Proteobacteria,2VU63@28216|Betaproteobacteria,373IP@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Lipopolysaccharide assembly protein A domain	-	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	LapA_dom
k59_576770_2	292415.Tbd_0959	9.71e-28	109.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,1KS26@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16
k59_216741_1	509190.Cseg_1739	4.49e-75	240.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRI3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.28	ko:K00141	ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667	RC00075	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_277067_2	1205680.CAKO01000038_gene1591	2e-17	75.9	2DMD4@1|root,32NV5@2|Bacteria,1RI0E@1224|Proteobacteria,2UA1F@28211|Alphaproteobacteria,2JZT3@204441|Rhodospirillales	204441|Rhodospirillales	S	Conserved hypothetical protein (Lin0512_fam)	-	-	-	-	-	-	-	-	-	-	-	-	Lin0512_fam
k59_53630_1	926550.CLDAP_16780	2.72e-96	295.0	COG5598@1|root,COG5598@2|Bacteria	2|Bacteria	H	trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_675007_1	1128421.JAGA01000002_gene387	5.92e-06	54.7	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1000023_1	436308.Nmar_1688	1.01e-51	164.0	COG0636@1|root,arCOG02455@2157|Archaea,41T6A@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_1000023_2	1229909.NSED_08985	7.25e-59	184.0	COG1781@1|root,arCOG04229@2157|Archaea,41SJT@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
k59_1022341_1	330214.NIDE4387	3.77e-35	134.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_675011_1	330214.NIDE0868	1.2e-86	266.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3187
k59_675014_1	998088.B565_1066	5.22e-18	84.7	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1Y3XY@135624|Aeromonadales	135624|Aeromonadales	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1000037_1	985054.JQEZ01000002_gene3088	5.1e-23	99.4	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,4NDGU@97050|Ruegeria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_576817_1	83406.HDN1F_06150	3.23e-80	253.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_576817_2	740709.A10D4_06526	7.55e-05	43.9	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,1RMR3@1236|Gammaproteobacteria,2QFU9@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Serine hydrolase involved in the detoxification of formaldehyde	fghA	GO:0003674,GO:0003824,GO:0004416,GO:0005488,GO:0005515,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016043,GO:0016787,GO:0016788,GO:0016790,GO:0016999,GO:0017001,GO:0017144,GO:0018738,GO:0022607,GO:0042221,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046292,GO:0046294,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0065003,GO:0070887,GO:0071704,GO:0071840,GO:0097237,GO:0098754,GO:0110095,GO:0110096,GO:1901575,GO:1901700,GO:1901701,GO:1990748	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	iAF1260.b0355,iBWG_1329.BWG_0244,iE2348C_1286.E2348C_2300,iECDH10B_1368.ECDH10B_0310,iECDH1ME8569_1439.ECDH1ME8569_0342,iEcDH1_1363.EcDH1_3251,iG2583_1286.G2583_0468,iJO1366.b0355,iY75_1357.Y75_RS01830	Esterase
k59_21748_1	1123393.KB891328_gene531	6.09e-31	123.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria,1KSBK@119069|Hydrogenophilales	119069|Hydrogenophilales	O	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
k59_216776_1	330214.NIDE3494	1.65e-07	54.3	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
k59_216776_2	1085623.GNIT_0287	2.24e-30	120.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mtrD_1	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_347628_1	323848.Nmul_A0647	1.97e-72	241.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,372CB@32003|Nitrosomonadales	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_511556_1	1192124.LIG30_2177	5.23e-11	62.8	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,2VRF6@28216|Betaproteobacteria,1K1FV@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
k59_511556_2	859657.RPSI07_1398	1.47e-37	134.0	COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,2VMRF@28216|Betaproteobacteria,1K0PC@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly	ureE	-	-	ko:K03187	-	-	-	-	ko00000	-	-	-	UreE_C,UreE_N
k59_444925_1	330214.NIDE0756	9.12e-88	274.0	COG0769@1|root,COG0769@2|Bacteria,3J0DS@40117|Nitrospirae	40117|Nitrospirae	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_791126_1	1120956.JHZK01000001_gene3373	1.52e-163	471.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,1JPPV@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_474680_1	1232410.KI421412_gene420	2.59e-103	301.0	28I53@1|root,2Z88I@2|Bacteria,1NE5N@1224|Proteobacteria,42QRB@68525|delta/epsilon subdivisions,2WMSD@28221|Deltaproteobacteria,43T55@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3750)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3750
k59_347633_1	1500890.JQNL01000001_gene2981	1.02e-18	94.4	COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,1RZBM@1236|Gammaproteobacteria,1X4YD@135614|Xanthomonadales	135614|Xanthomonadales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_216791_1	693746.OBV_07870	7.01e-25	95.9	COG2963@1|root,COG2963@2|Bacteria,1VBPK@1239|Firmicutes,24W69@186801|Clostridia,2N8JQ@216572|Oscillospiraceae	186801|Clostridia	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_53677_1	631454.N177_4194	8.22e-101	301.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,1JPM2@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	livH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_184397_1	264198.Reut_A2908	2.62e-06	49.3	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJJD@28216|Betaproteobacteria,1K1EB@119060|Burkholderiaceae	28216|Betaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_184397_2	985867.AEWF01000001_gene1760	1.16e-21	89.4	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,2U728@28211|Alphaproteobacteria,47G8A@766|Rickettsiales	766|Rickettsiales	E	Glyoxalase-like domain	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
k59_768708_1	388051.AUFE01000065_gene3874	1.76e-37	143.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2VMJ9@28216|Betaproteobacteria,1K26K@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_768708_2	983548.Krodi_1492	3.53e-06	48.1	COG0396@1|root,COG0396@2|Bacteria,4NEMY@976|Bacteroidetes,1HWTU@117743|Flavobacteriia,37EAN@326319|Dokdonia	976|Bacteroidetes	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_53683_1	1100720.ALKN01000035_gene975	4.14e-40	137.0	COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,2VUSK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_474689_1	1288494.EBAPG3_17910	8.45e-152	452.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,371SW@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_379574_1	945713.IALB_3166	8.39e-56	180.0	COG0313@1|root,COG0313@2|Bacteria	2|Bacteria	H	rRNA processing	rsmI_1	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_838394_1	316067.Geob_0877	3.04e-17	79.0	COG2050@1|root,COG2050@2|Bacteria,1N5HF@1224|Proteobacteria,42RQZ@68525|delta/epsilon subdivisions,2WNIY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_838394_2	1123504.JQKD01000005_gene4787	2.91e-30	117.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VJ7Q@28216|Betaproteobacteria,4AC45@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_216809_2	1459636.NTE_01850	2.23e-20	90.5	COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_534666_1	468059.AUHA01000002_gene563	2.3e-44	162.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
k59_119477_1	314254.OA2633_13080	3.42e-52	182.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,43W9P@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	M13 family peptidase	-	-	3.4.24.71	ko:K01415,ko:K07386	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_53694_1	379066.GAU_2628	6.46e-24	100.0	COG2957@1|root,COG2957@2|Bacteria,1ZSZ0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
k59_410490_1	557598.LHK_00699	7.15e-85	259.0	COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,2VJ81@28216|Betaproteobacteria,2KQEX@206351|Neisseriales	206351|Neisseriales	IQ	KR domain	fabG2	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_410490_2	1266925.JHVX01000001_gene2506	1.09e-38	132.0	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,2VQT7@28216|Betaproteobacteria,3730C@32003|Nitrosomonadales	28216|Betaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_247190_1	234267.Acid_7639	2.23e-203	577.0	COG3344@1|root,COG3344@2|Bacteria,3Y46K@57723|Acidobacteria	57723|Acidobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1,RVT_N
k59_1000987_2	305700.B447_08129	1.14e-36	126.0	COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,2VRX8@28216|Betaproteobacteria,2KYU2@206389|Rhodocyclales	206389|Rhodocyclales	H	Pterin 4 alpha carbinolamine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Pterin_4a
k59_445882_2	744980.TRICHSKD4_0405	1.11e-50	167.0	COG0395@1|root,COG0395@2|Bacteria,1MVRG@1224|Proteobacteria,2TSEK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type sugar transport system, permease component	MA20_44780	-	-	ko:K17323	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	BPD_transp_1
k59_185233_1	395495.Lcho_2697	5.97e-132	395.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,1KK96@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Methylmalonyl-CoA mutase	icmF	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_969761_1	330214.NIDE0400	4.05e-47	153.0	COG0292@1|root,COG0292@2|Bacteria,3J0SF@40117|Nitrospirae	40117|Nitrospirae	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_969761_2	635013.TherJR_1870	3.61e-08	56.6	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,2602M@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
k59_642325_1	436308.Nmar_0535	7.37e-46	152.0	COG2004@1|root,arCOG04182@2157|Archaea,41SWI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS24 family	-	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
k59_217738_1	1121405.dsmv_3267	2.83e-76	245.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	ribonuclease Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_847804_1	1095769.CAHF01000021_gene882	1.99e-124	378.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,4747B@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_978124_1	1121405.dsmv_0302	9.93e-76	241.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2MHTM@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_482368_1	1297570.MESS4_670041	6.12e-89	275.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_254252_1	335283.Neut_0860	7.1e-176	520.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,371W3@32003|Nitrosomonadales	28216|Betaproteobacteria	C	dehydrogenase, E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_62300_1	335543.Sfum_3525	2.42e-57	193.0	COG0446@1|root,COG0446@2|Bacteria,1QXXG@1224|Proteobacteria,42Z3E@68525|delta/epsilon subdivisions,2WU93@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_254256_1	1332071.L581_1978	2.32e-11	65.5	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,40144@613|Serratia	1236|Gammaproteobacteria	P	Sulfurtransferase	sseA	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016782,GO:0016783,GO:0016784,GO:0031668,GO:0033554,GO:0034641,GO:0042221,GO:0042262,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	iECs_1301.ECs3387,iZ_1308.Z3788	Rhodanese
k59_387949_1	497321.C664_07788	9.89e-121	351.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2VIVI@28216|Betaproteobacteria,2KVR9@206389|Rhodocyclales	206389|Rhodocyclales	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_717081_1	449447.MAE_12400	2.1e-46	171.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	bhp	-	-	ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001,ko02000	1.B.40.2	-	-	B_lectin,Big_3_2,Big_5,Calx-beta,DUF4347,HemolysinCabind
k59_225462_1	555778.Hneap_2214	1.48e-71	230.0	COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,1RN0A@1236|Gammaproteobacteria,1WZMA@135613|Chromatiales	135613|Chromatiales	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_482379_1	1229909.NSED_01430	1.31e-143	418.0	COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_909991_1	987059.RBXJA2T_04503	1.24e-85	283.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1KJJ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_847819_2	580332.Slit_1793	1.19e-209	600.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,44VEM@713636|Nitrosomonadales	28216|Betaproteobacteria	O	TIGRFAM cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_128443_1	1288494.EBAPG3_13140	1.12e-144	417.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,372I8@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_128443_2	997296.PB1_13444	1.14e-41	143.0	COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,4HIGJ@91061|Bacilli,1ZG71@1386|Bacillus	91061|Bacilli	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	dfrA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
k59_128443_3	546268.NEISUBOT_03712	2.62e-101	300.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,2KPIK@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_1027055_1	305700.B447_16101	4.43e-73	242.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,2KUQF@206389|Rhodocyclales	206389|Rhodocyclales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	-
k59_356707_1	1110697.NCAST_08_00870	1.13e-35	139.0	COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria,4FXDH@85025|Nocardiaceae	201174|Actinobacteria	CP	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_387961_1	436308.Nmar_0115	3.06e-156	451.0	COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_878518_2	436308.Nmar_1727	9.57e-76	244.0	COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota	651137|Thaumarchaeota	S	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
k59_62328_1	1000565.METUNv1_02133	6.61e-50	172.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,2KUN3@206389|Rhodocyclales	206389|Rhodocyclales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_978158_1	3885.XP_007138957.1	1.31e-28	115.0	COG1622@1|root,KOG4767@2759|Eukaryota,37T4F@33090|Viridiplantae,3GGAX@35493|Streptophyta,4JT1W@91835|fabids	35493|Streptophyta	C	Cytochrome C oxidase, subunit	cox2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034641,GO:0042773,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564	-	ko:K02261	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX2,COX2_TM
k59_254280_1	319003.Bra1253DRAFT_06429	1.23e-45	160.0	COG0745@1|root,COG0745@2|Bacteria,1MX29@1224|Proteobacteria,2TV8G@28211|Alphaproteobacteria,3JR5C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_321665_1	768066.HELO_3480	4.39e-49	166.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1XH8Y@135619|Oceanospirillales	135619|Oceanospirillales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_978163_1	909663.KI867150_gene2890	3.84e-53	179.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,42PA3@68525|delta/epsilon subdivisions,2WM6X@28221|Deltaproteobacteria,2MQSC@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
k59_356718_2	697282.Mettu_3216	1.04e-14	74.7	COG4967@1|root,COG4967@2|Bacteria,1RKKA@1224|Proteobacteria	1224|Proteobacteria	NU	type IV pilus modification protein PilV	-	-	-	ko:K10927	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	N_methyl
k59_847837_1	330214.NIDE3884	1.1e-46	163.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	sorA	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_910014_1	1485544.JQKP01000002_gene1448	1.5e-57	188.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,44V2D@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
k59_910014_2	857087.Metme_0746	1.41e-16	76.6	2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,1SD8N@1236|Gammaproteobacteria,1XFAR@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2782)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2782
k59_910014_3	323848.Nmul_A0568	4.49e-80	262.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,372B8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1027064_1	984262.SGRA_0031	2.06e-105	324.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes	976|Bacteroidetes	E	Glutamate formimidoyltransferase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
k59_161026_2	1254432.SCE1572_36420	7.6e-36	127.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,43BFC@68525|delta/epsilon subdivisions,2X6TQ@28221|Deltaproteobacteria,2Z3CQ@29|Myxococcales	28221|Deltaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_776863_1	261292.Nit79A3_0774	7.65e-137	394.0	COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2WGMS@28216|Betaproteobacteria,3721D@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_776863_2	713586.KB900536_gene1926	0.000327	40.8	2END2@1|root,33G0J@2|Bacteria,1NIFI@1224|Proteobacteria,1SHCA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_128474_1	330214.NIDE3664	5.3e-81	249.0	COG0679@1|root,COG0679@2|Bacteria,3J1EB@40117|Nitrospirae	40117|Nitrospirae	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_161027_1	390235.PputW619_2790	2.85e-38	144.0	COG4191@1|root,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,1SC56@1236|Gammaproteobacteria,1YXXE@136845|Pseudomonas putida group	1236|Gammaproteobacteria	T	Integral membrane sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_878540_1	1265490.JHVY01000023_gene2127	3.4e-57	187.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RRPI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CE	Tartrate dehydrogenase	tdh	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
k59_878540_2	471854.Dfer_4181	5.54e-17	82.0	COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,47JS6@768503|Cytophagia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH
k59_910017_1	159087.Daro_1900	1.97e-101	309.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KVHE@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_30782_1	868864.Dester_0409	2.54e-60	193.0	COG0177@1|root,COG0177@2|Bacteria,2G3TX@200783|Aquificae	200783|Aquificae	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_586336_1	1249634.D781_3419	1.79e-55	191.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PUMN@1224|Proteobacteria,1RYSS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_161038_1	472759.Nhal_1541	1.5e-62	204.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RCFZ@1224|Proteobacteria,1S2QS@1236|Gammaproteobacteria,1X1B9@135613|Chromatiales	135613|Chromatiales	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_482420_1	1121438.JNJA01000001_gene2064	8.9e-102	301.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2MA2P@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_586341_1	570967.JMLV01000001_gene2799	1.58e-48	167.0	2DG8R@1|root,2ZUYV@2|Bacteria,1R8VA@1224|Proteobacteria,2VGKJ@28211|Alphaproteobacteria,2JZ9B@204441|Rhodospirillales	204441|Rhodospirillales	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
k59_684485_1	390235.PputW619_3456	8.27e-05	45.1	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1YWI2@136845|Pseudomonas putida group	1236|Gammaproteobacteria	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN746.PP_2215	Thiolase_C,Thiolase_N
k59_684485_2	1380356.JNIK01000019_gene239	2.45e-09	60.8	COG0642@1|root,COG0745@1|root,COG2172@1|root,COG0745@2|Bacteria,COG2172@2|Bacteria,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GAF_2,HAMP,HATPase_c,HATPase_c_2,HisKA,PAS_4,Response_reg,SpoIIE
k59_848735_2	1297863.APJF01000001_gene2298	3.36e-06	49.7	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria,3JSAM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF502)	MA20_12960	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_226289_1	1121035.AUCH01000002_gene1682	4.27e-88	270.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,2KUP3@206389|Rhodocyclales	206389|Rhodocyclales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_97385_1	1396418.BATQ01000050_gene289	1.02e-21	96.3	COG0745@1|root,COG0784@1|root,COG0840@1|root,COG1511@1|root,COG2770@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG0840@2|Bacteria,COG1511@2|Bacteria,COG2770@2|Bacteria,COG5002@2|Bacteria,46SI7@74201|Verrucomicrobia,2IV43@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
k59_97385_2	945713.IALB_2133	3.29e-19	86.7	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	ycjS	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_282374_1	439235.Dalk_5087	2.96e-148	429.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_910823_1	247639.MGP2080_05657	5.1e-30	120.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_521887_2	1218084.BBJK01000016_gene1759	8.27e-15	75.5	COG2067@1|root,COG2067@2|Bacteria,1RJIQ@1224|Proteobacteria,2WFUS@28216|Betaproteobacteria,1KA6V@119060|Burkholderiaceae	28216|Betaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_31651_1	330214.NIDE1090	1.32e-09	58.5	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_31651_2	330214.NIDE1091	3.26e-62	199.0	COG0167@1|root,COG0167@2|Bacteria,3J145@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.98.1	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_63150_2	1499680.CCFE01000030_gene3624	1.6e-10	60.8	COG3104@1|root,COG3104@2|Bacteria,1TP81@1239|Firmicutes,4HAF2@91061|Bacilli,1ZAVZ@1386|Bacillus	91061|Bacilli	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_357619_2	1125863.JAFN01000001_gene1075	6.82e-41	142.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,42PUJ@68525|delta/epsilon subdivisions,2WM9G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_946238_1	522306.CAP2UW1_1590	1.1e-112	358.0	COG0296@1|root,COG1523@1|root,COG0296@2|Bacteria,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_879344_1	945713.IALB_0065	5.37e-134	393.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	ybjT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2867,Epimerase,NAD_binding_10
k59_97396_1	1089551.KE386572_gene4036	2.33e-07	51.2	COG1359@1|root,COG1359@2|Bacteria,1N98F@1224|Proteobacteria,2UFXS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_97396_2	1453503.AU05_07530	3.37e-28	114.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1027479_1	123899.JPQP01000001_gene1737	6.06e-47	163.0	COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2VJB5@28216|Betaproteobacteria,3T9IX@506|Alcaligenaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_651018_2	305700.B447_16036	2.07e-49	160.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,2KWNI@206389|Rhodocyclales	206389|Rhodocyclales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_651018_3	522306.CAP2UW1_3478	4.04e-53	171.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2VQ4W@28216|Betaproteobacteria,1KQ0Y@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_587233_1	1121405.dsmv_1991	2.55e-140	408.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	nuoF-2	-	1.6.5.3	ko:K00334,ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_255061_1	1071679.BG57_22035	6.14e-14	71.2	COG5488@1|root,COG5488@2|Bacteria,1N5Z9@1224|Proteobacteria,2VU1W@28216|Betaproteobacteria,1K6XS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
k59_255061_2	697282.Mettu_0140	6.09e-22	95.5	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XECZ@135618|Methylococcales	135618|Methylococcales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_388929_1	1266925.JHVX01000008_gene285	0.0	1098.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,372NK@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_97407_1	56780.SYN_01459	1.55e-115	337.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990,ko:K01992,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC2_membrane_3,ABC_tran
k59_651027_1	330214.NIDE3387	8.01e-131	384.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_879359_1	981384.AEYW01000006_gene2251	2.12e-38	138.0	COG2267@1|root,COG2267@2|Bacteria,1QTNZ@1224|Proteobacteria,2V255@28211|Alphaproteobacteria,4ND6G@97050|Ruegeria	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_651031_1	1121351.AUAP01000001_gene701	2.17e-69	216.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,2KQWG@206351|Neisseriales	206351|Neisseriales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_685356_1	1123053.AUDG01000013_gene1176	6.82e-09	55.8	2C19Z@1|root,2Z826@2|Bacteria,1RBG1@1224|Proteobacteria,1RZFJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_135137_2	1125863.JAFN01000001_gene1233	2.02e-46	155.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42S8R@68525|delta/epsilon subdivisions,2WSA2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_135137_3	5786.XP_003283197.1	1.3e-31	124.0	COG0235@1|root,KOG3699@2759|Eukaryota,3XGGN@554915|Amoebozoa	554915|Amoebozoa	TZ	Class II Aldolase and Adducin N-terminal domain	-	-	-	ko:K18622	-	-	-	-	ko00000,ko04812	-	-	-	Aldolase_II
k59_135137_5	635013.TherJR_0207	7.94e-12	63.2	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,2622Z@186807|Peptococcaceae	186801|Clostridia	S	THIoesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_722751_1	1316936.K678_16580	3.79e-27	113.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria,2JP8P@204441|Rhodospirillales	204441|Rhodospirillales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_754532_1	1499967.BAYZ01000041_gene2365	7.8e-35	131.0	COG0028@1|root,COG0028@2|Bacteria,2NNMW@2323|unclassified Bacteria	2|Bacteria	EH	thiamine pyrophosphate protein TPP binding domain protein	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_754532_2	1196029.ALIM01000004_gene4284	2.24e-52	172.0	COG1082@1|root,COG1082@2|Bacteria,1UZZY@1239|Firmicutes,4HCGS@91061|Bacilli,1ZFCY@1386|Bacillus	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_4432_1	715451.ambt_06360	1.97e-31	116.0	2DQ56@1|root,334T2@2|Bacteria,1QUYU@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4262)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4262
k59_951162_1	215803.DB30_3561	2.54e-63	209.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWSR@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_690251_1	945713.IALB_0840	1.01e-32	124.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_754540_1	768671.ThimaDRAFT_0369	4.57e-13	66.6	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1WX78@135613|Chromatiales	135613|Chromatiales	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
k59_754540_2	713586.KB900536_gene2898	1.55e-33	125.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_559629_2	391038.Bphy_4185	5.56e-07	51.2	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2VS28@28216|Betaproteobacteria,1K1EV@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome b561	cybB	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_428632_1	1408473.JHXO01000005_gene1461	3.54e-63	208.0	COG0168@1|root,COG0168@2|Bacteria,4NGMF@976|Bacteroidetes,2FNQZ@200643|Bacteroidia	976|Bacteroidetes	P	potassium uptake protein, TrkH family	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_37144_1	592015.HMPREF1705_01687	2.67e-51	185.0	COG1615@1|root,COG1615@2|Bacteria,3TANI@508458|Synergistetes	508458|Synergistetes	S	UPF0182 protein	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_69905_1	999541.bgla_2g18360	1.06e-58	196.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2VH7T@28216|Betaproteobacteria,1K4ZW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	2-methylcitrate dehydratase	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
k59_918795_1	1288494.EBAPG3_920	3.35e-124	362.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,37274@32003|Nitrosomonadales	28216|Betaproteobacteria	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_690262_1	1429916.X566_17350	1.27e-71	228.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,3JT4Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_265663_1	305700.B447_12157	4.51e-23	96.7	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,2KUWU@206389|Rhodocyclales	206389|Rhodocyclales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_265663_2	335283.Neut_2306	8.72e-22	93.6	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,372NZ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_37153_1	243365.CV_2914	2.41e-60	201.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,2KQ8S@206351|Neisseriales	206351|Neisseriales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_722780_1	742766.HMPREF9455_03696	1.25e-19	91.7	COG3547@1|root,COG3547@2|Bacteria,4NHYP@976|Bacteroidetes,2FKYS@200643|Bacteroidia	976|Bacteroidetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_526309_1	1121033.AUCF01000016_gene5419	2.2e-95	288.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2JPCP@204441|Rhodospirillales	204441|Rhodospirillales	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
k59_559644_1	7668.SPU_028323-tr	9.56e-48	160.0	2BG5J@1|root,2S18N@2759|Eukaryota,3A435@33154|Opisthokonta,3BRGG@33208|Metazoa,3D8KM@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_37154_1	1095769.CAHF01000011_gene2632	1.06e-129	383.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,473CK@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	fdwB	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_135179_1	330214.NIDE3060	5.15e-137	390.0	COG2022@1|root,COG2022@2|Bacteria,3J0EI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
k59_363347_1	1283284.AZUK01000001_gene1793	1.83e-127	371.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RUI0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_559646_2	330214.NIDE0431	1.25e-29	119.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,VCBS
k59_820856_1	297246.lpp2727	4.39e-08	55.1	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1JCXU@118969|Legionellales	118969|Legionellales	L	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	yhhF	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_820856_2	153948.NAL212_0452	7.37e-60	188.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,37305@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_722785_1	1163617.SCD_n00618	5.75e-191	570.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_593292_2	1071679.BG57_17885	2.8e-68	224.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,1JZXA@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_136313_2	748247.AZKH_0928	6.68e-10	59.3	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,2KU74@206389|Rhodocyclales	206389|Rhodocyclales	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_233333_1	443152.MDG893_11081	1.39e-40	149.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,1RME6@1236|Gammaproteobacteria,465W8@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_233333_2	864051.BurJ1DRAFT_3660	1.78e-78	241.0	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,2VJDD@28216|Betaproteobacteria,1KPIP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	membrane protein, terc	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_593300_1	589865.DaAHT2_2517	4.91e-10	58.5	COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,42U8N@68525|delta/epsilon subdivisions,2WQSA@28221|Deltaproteobacteria,2MKPM@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Na+/H+ ion antiporter subunit	mnhE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_364472_1	545243.BAEV01000085_gene2398	5.86e-13	73.6	COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,36DNW@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
k59_919966_1	314285.KT71_00910	2.81e-56	176.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1JA77@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_984690_1	535289.Dtpsy_1066	2.92e-67	228.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,4A9W6@80864|Comamonadaceae	28216|Betaproteobacteria	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_560812_1	42565.FP66_00040	3.19e-33	121.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1XKFB@135619|Oceanospirillales	135619|Oceanospirillales	G	PTS fructose transporter subunit IIA	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_822051_1	945713.IALB_1701	2.58e-40	149.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_396563_1	879212.DespoDRAFT_00043	3.88e-15	77.0	2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,42UIS@68525|delta/epsilon subdivisions,2WR4F@28221|Deltaproteobacteria,2MQ0N@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
k59_785346_1	261292.Nit79A3_3001	3.35e-177	514.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,372ME@32003|Nitrosomonadales	28216|Betaproteobacteria	I	AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_201466_1	760011.Spico_1774	3.88e-41	148.0	COG0002@1|root,COG0002@2|Bacteria,2J5UE@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_822068_1	999541.bgla_1g01150	1.52e-101	313.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,1K005@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	ilvG	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_625877_1	1286093.C266_16875	1.36e-92	284.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,1K2GP@119060|Burkholderiaceae	28216|Betaproteobacteria	I	fatty acid desaturase	ole1	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_886578_1	1538295.JY96_12895	1.75e-24	103.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,1KJ5A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
k59_886578_2	469610.HMPREF0189_00739	1.57e-19	86.7	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,1KJFK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	acetylornithine	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_952443_2	596154.Alide2_0879	1.37e-49	164.0	2DZKR@1|root,32VDB@2|Bacteria,1RBUG@1224|Proteobacteria,2VQA7@28216|Betaproteobacteria,4ADGA@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_266832_1	436308.Nmar_0043	2.33e-103	310.0	COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_723981_1	945713.IALB_0431	3e-51	169.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
k59_38323_1	945713.IALB_1064	1.08e-52	169.0	COG1956@1|root,COG1956@2|Bacteria	2|Bacteria	T	GAF domain-containing protein	yebR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0033745,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.8.4.14,3.1.3.3	ko:K02584,ko:K07315,ko:K08968	ko00270,ko02020,map00270,map02020	-	R02025	RC00639	ko00000,ko00001,ko01000,ko03000,ko03021	-	-	-	GAF_2
k59_38323_2	760192.Halhy_3596	6.15e-31	121.0	COG2812@1|root,COG2812@2|Bacteria,4NE8A@976|Bacteroidetes,1IQ35@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_822080_2	1122947.FR7_4292	9.78e-39	144.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,4H31M@909932|Negativicutes	909932|Negativicutes	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_4,Fer4_8,RnfC_N,SLBB
k59_854238_1	1123508.JH636454_gene5743	4.64e-97	295.0	COG1783@1|root,COG1783@2|Bacteria	2|Bacteria	S	DNA packaging	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
k59_299113_1	386456.JQKN01000027_gene12	1.56e-08	61.2	arCOG02488@1|root,arCOG02516@1|root,arCOG06534@1|root,arCOG02488@2157|Archaea,arCOG02516@2157|Archaea,arCOG06534@2157|Archaea,2Y7W8@28890|Euryarchaeota,23PZB@183925|Methanobacteria	183925|Methanobacteria	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_299114_1	1101195.Meth11DRAFT_1196	1.17e-32	131.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,2KM41@206350|Nitrosomonadales	206350|Nitrosomonadales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	GlnD_UR_UTase,HD,NTP_transf_2
k59_691499_1	945713.IALB_2225	1.42e-103	317.0	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_920017_1	545264.KB898757_gene2468	3.99e-49	177.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_364520_1	1121924.ATWH01000022_gene3197	1.71e-07	55.8	COG0715@1|root,COG0715@2|Bacteria,2I93G@201174|Actinobacteria,4FRU3@85023|Microbacteriaceae	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_593354_1	1229909.NSED_09820	2.51e-12	61.6	arCOG08816@1|root,arCOG08816@2157|Archaea,41TAW@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_593354_2	436308.Nmar_0038	1.55e-90	268.0	COG0302@1|root,arCOG04542@2157|Archaea,41SGC@651137|Thaumarchaeota	651137|Thaumarchaeota	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_886597_1	305700.B447_10857	3.16e-146	431.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KV59@206389|Rhodocyclales	206389|Rhodocyclales	I	poly(R)-hydroxyalkanoic acid synthase	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_71197_1	323848.Nmul_A2690	5e-106	316.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,372YX@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_755533_1	1246459.KB898353_gene548	1.43e-90	278.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2U4SQ@28211|Alphaproteobacteria,4BC89@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Amino acid permease	potE	-	-	ko:K03756,ko:K03759	-	-	-	-	ko00000,ko02000	2.A.3.2	-	-	AA_permease_2
k59_209038_1	1121405.dsmv_3105	2.24e-109	318.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2WK74@28221|Deltaproteobacteria,2MJ0K@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_992226_1	1123060.JONP01000024_gene2528	2.08e-109	329.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2TVHP@28211|Alphaproteobacteria,2JY55@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_992226_2	1203554.HMPREF1476_02115	2.36e-31	115.0	2CJPW@1|root,32SAH@2|Bacteria,1NAJ3@1224|Proteobacteria,2W4DG@28216|Betaproteobacteria,4PR79@995019|Sutterellaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_666789_1	639283.Snov_0512	1.04e-80	250.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,3EY3I@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_530852_1	671143.DAMO_3066	1.4e-33	130.0	COG0318@1|root,COG0318@2|Bacteria,2NQWW@2323|unclassified Bacteria	2|Bacteria	IQ	AMP-binding enzyme	JD73_00810	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2
k59_46047_1	1123057.P872_24735	6.15e-33	127.0	COG0490@1|root,COG0569@1|root,COG1226@1|root,COG0490@2|Bacteria,COG0569@2|Bacteria,COG1226@2|Bacteria,4NG7W@976|Bacteroidetes,47N8E@768503|Cytophagia	976|Bacteroidetes	U	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_339777_1	436308.Nmar_0512	1.25e-94	284.0	COG1522@1|root,arCOG01628@2157|Archaea,41SA2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_339777_2	1229909.NSED_02575	1.13e-20	84.0	arCOG10528@1|root,arCOG10528@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_306297_2	948106.AWZT01000027_gene319	9.13e-20	87.0	COG0745@1|root,COG0745@2|Bacteria,1RBJ1@1224|Proteobacteria,2VQ7Q@28216|Betaproteobacteria,1KGNS@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_144119_1	1229909.NSED_07785	1.37e-95	283.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_633495_1	396588.Tgr7_2411	2.05e-87	266.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1WWVX@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_666806_1	113395.AXAI01000021_gene3463	3.74e-43	160.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_340733_1	945713.IALB_1767	1.28e-105	318.0	COG0008@1|root,COG1384@1|root,COG0008@2|Bacteria,COG1384@2|Bacteria	2|Bacteria	J	tRNA binding	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_700605_1	323848.Nmul_A2334	4.64e-78	254.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,371M3@32003|Nitrosomonadales	28216|Betaproteobacteria	E	extracellular solute-binding protein, family 5	oppA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_788339_1	857087.Metme_0929	5.29e-42	157.0	COG1452@1|root,COG3266@1|root,COG1452@2|Bacteria,COG3266@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1XETE@135618|Methylococcales	135618|Methylococcales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
k59_894831_1	76114.ebA6829	2.15e-70	235.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0454@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales	206389|Rhodocyclales	CM	Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_14726_1	1408164.MOLA814_00646	2.04e-114	340.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_504499_1	679201.HMPREF9334_01541	1.32e-07	58.5	COG0470@1|root,COG0470@2|Bacteria,1TRVS@1239|Firmicutes,4H3FX@909932|Negativicutes	909932|Negativicutes	L	DNA polymerase III	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_602070_1	338969.Rfer_0173	2.81e-17	77.0	COG3874@1|root,COG3874@2|Bacteria,1N4RT@1224|Proteobacteria	1224|Proteobacteria	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
k59_961509_1	1120999.JONM01000001_gene1070	5.53e-51	182.0	COG0348@1|root,COG1251@1|root,COG0348@2|Bacteria,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,2KSEV@206351|Neisseriales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Fer2,Pyr_redox_2
k59_667832_1	717785.HYPMC_0929	6.88e-75	232.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,3N6UA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_862700_1	395494.Galf_2498	6.42e-16	84.3	2A8Z1@1|root,30Y2U@2|Bacteria,1PJYG@1224|Proteobacteria,2VJ83@28216|Betaproteobacteria,44W4N@713636|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_928941_1	204773.HEAR1108	3.28e-82	253.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,472NW@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_634483_1	1385935.N836_30135	1.15e-81	271.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1G02W@1117|Cyanobacteria,1H8RM@1150|Oscillatoriales	1117|Cyanobacteria	EQ	N-methylhydantoinase B acetone carboxylase alpha subunit	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_47016_1	1150600.ADIARSV_0061	3.08e-28	114.0	COG2207@1|root,COG2207@2|Bacteria,4NGS3@976|Bacteroidetes,1J0H6@117747|Sphingobacteriia	976|Bacteroidetes	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
k59_209977_1	945713.IALB_2749	8.31e-11	63.2	2CGDR@1|root,336BW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_307204_2	945713.IALB_0780	1.4e-15	75.5	COG1427@1|root,COG1427@2|Bacteria	2|Bacteria	E	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	1.21.98.1,4.2.1.151	ko:K07081,ko:K11782,ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588,R10666	RC02329,RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
k59_307209_1	395494.Galf_2384	6.45e-54	188.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2VMAN@28216|Betaproteobacteria,44WCY@713636|Nitrosomonadales	28216|Betaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_569783_3	1499968.TCA2_1736	2.15e-18	89.7	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,4HAKY@91061|Bacilli,26QTU@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	idhA	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_894875_1	1229909.NSED_08945	2.26e-69	233.0	COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota	651137|Thaumarchaeota	V	resistance protein	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
k59_47039_1	1121920.AUAU01000022_gene2452	6.67e-24	93.6	COG0776@1|root,COG0776@2|Bacteria,3Y55Y@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_47039_2	1123236.KB899388_gene2068	3.31e-09	57.4	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,466WC@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1019077_1	580332.Slit_1678	2.19e-110	336.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,44V9S@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_21,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_634517_1	1163617.SCD_n00796	2.81e-57	193.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	peptidase m48, ste24p	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_862735_1	903818.KI912269_gene521	1.44e-49	175.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1,PTR2
k59_273675_1	1341151.ASZU01000001_gene675	3.2e-92	285.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,4HACW@91061|Bacilli,27BMB@186824|Thermoactinomycetaceae	91061|Bacilli	F	Adenylosuccinate lyase C-terminus	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09895	ADSL_C,Lyase_1
k59_762676_1	1121033.AUCF01000047_gene142	3.46e-95	293.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,2JW49@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_831184_1	595537.Varpa_5315	2.03e-67	214.0	COG2267@1|root,COG2267@2|Bacteria,1R41P@1224|Proteobacteria,2WGZC@28216|Betaproteobacteria,4AGAA@80864|Comamonadaceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_862737_2	42565.FP66_08880	8.93e-10	62.0	COG0589@1|root,COG0589@2|Bacteria,1N7EK@1224|Proteobacteria,1SCRX@1236|Gammaproteobacteria,1XMGK@135619|Oceanospirillales	135619|Oceanospirillales	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_569801_1	365046.Rta_12010	1.03e-88	266.0	COG4340@1|root,COG4340@2|Bacteria,1R9YQ@1224|Proteobacteria,2VHC5@28216|Betaproteobacteria,4A9P8@80864|Comamonadaceae	28216|Betaproteobacteria	S	2OG-Fe dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-Fe_Oxy_2
k59_468883_1	1100720.ALKN01000028_gene2458	4.93e-94	300.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,4ACHC@80864|Comamonadaceae	28216|Betaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_831195_1	330214.NIDE1223	7.81e-06	47.0	COG2204@1|root,COG2204@2|Bacteria,3J0C2@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_831195_2	330214.NIDE1222	3.72e-65	218.0	COG5000@1|root,COG5000@2|Bacteria,3J0B7@40117|Nitrospirae	40117|Nitrospirae	T	GHKL domain	-	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS
k59_80163_1	1439940.BAY1663_04106	1.17e-42	150.0	2BRG7@1|root,32KF4@2|Bacteria,1REC2@1224|Proteobacteria,1SVQK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
k59_634537_2	94624.Bpet2679	9.64e-126	374.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,3T5BW@506|Alcaligenaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_403740_1	926569.ANT_15080	5.75e-28	114.0	COG1572@1|root,COG1572@2|Bacteria,2G9M8@200795|Chloroflexi	2|Bacteria	S	Ig-like domain from next to BRCA1 gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,N_BRCA1_IG
k59_667903_1	331635.G5S_1028	1.25e-19	85.1	COG0164@1|root,COG0164@2|Bacteria,2JFYJ@204428|Chlamydiae	204428|Chlamydiae	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_667903_2	545264.KB898750_gene254	2.11e-35	126.0	COG5615@1|root,COG5615@2|Bacteria,1RH6D@1224|Proteobacteria,1S6S2@1236|Gammaproteobacteria,1WZE3@135613|Chromatiales	135613|Chromatiales	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
k59_438225_2	330214.NIDE3269	3.33e-92	282.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_667907_1	472759.Nhal_3838	8.91e-38	139.0	COG0576@1|root,COG0811@1|root,COG0576@2|Bacteria,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1S2ZN@1236|Gammaproteobacteria,1WZ7W@135613|Chromatiales	135613|Chromatiales	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_667907_2	472759.Nhal_3837	1.99e-31	118.0	COG0811@1|root,COG0811@2|Bacteria,1NZ0Y@1224|Proteobacteria,1SQUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_403745_1	395494.Galf_0590	6.3e-38	138.0	2DP0A@1|root,3300Q@2|Bacteria,1N78Y@1224|Proteobacteria,2VVZ5@28216|Betaproteobacteria,44VYM@713636|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Sporulation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_504593_1	945713.IALB_2895	1.61e-05	46.2	COG0719@1|root,COG0719@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
k59_504593_2	471854.Dfer_2039	4.83e-40	148.0	COG0520@1|root,COG0520@2|Bacteria,4NDUB@976|Bacteroidetes,47NQT@768503|Cytophagia	976|Bacteroidetes	H	Aminotransferase class-V	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_340836_1	596154.Alide2_4007	9.45e-79	244.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VHCB@28216|Betaproteobacteria,4AA8K@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	qor1	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_929033_1	945713.IALB_0218	5.67e-80	249.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
k59_403752_1	1459636.NTE_01739	1.5e-104	311.0	COG0644@1|root,arCOG00570@2157|Archaea,41SCG@651137|Thaumarchaeota	2157|Archaea	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,NAD_binding_8,Pyr_redox_2
k59_894932_1	1218074.BAXZ01000003_gene467	1.46e-39	143.0	COG4360@1|root,COG4360@2|Bacteria,1RDRJ@1224|Proteobacteria,2VSAU@28216|Betaproteobacteria,1K35M@119060|Burkholderiaceae	28216|Betaproteobacteria	F	ATP adenylyltransferase	-	-	2.7.7.53	ko:K00988	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	ATP_transf
k59_80192_1	278197.PEPE_0850	7.43e-42	140.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,3F6K4@33958|Lactobacillaceae	91061|Bacilli	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_177769_1	292415.Tbd_0425	1.39e-93	285.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,1KRD8@119069|Hydrogenophilales	119069|Hydrogenophilales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_929035_1	631362.Thi970DRAFT_04215	5.25e-89	266.0	COG3751@1|root,COG3751@2|Bacteria,1RBXB@1224|Proteobacteria,1RR8W@1236|Gammaproteobacteria,1WWUG@135613|Chromatiales	135613|Chromatiales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
k59_504608_1	248742.XP_005647419.1	6.07e-48	167.0	COG0596@1|root,KOG2565@2759|Eukaryota,380C4@33090|Viridiplantae	33090|Viridiplantae	S	Epoxide hydrolase N terminus	-	-	-	-	-	-	-	-	-	-	-	-	EHN
k59_961609_1	1123392.AQWL01000006_gene596	8.23e-87	276.0	COG0152@1|root,COG0628@1|root,COG0152@2|Bacteria,COG0628@2|Bacteria,1MUR9@1224|Proteobacteria,2VGZK@28216|Betaproteobacteria,1KSDD@119069|Hydrogenophilales	119069|Hydrogenophilales	F	SAICAR synthetase	-	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	AI-2E_transport,SAICAR_synt
k59_569856_1	1232410.KI421425_gene1549	2.53e-79	263.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_667940_1	640081.Dsui_2926	1.14e-28	115.0	COG2199@1|root,COG3706@2|Bacteria,1R59V@1224|Proteobacteria,2VN7N@28216|Betaproteobacteria,2KUR6@206389|Rhodocyclales	206389|Rhodocyclales	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
k59_373005_1	1175306.GWL_13090	5.49e-145	421.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,473AW@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_504618_1	765910.MARPU_01715	5.86e-14	71.6	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales	135613|Chromatiales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_504618_2	1033802.SSPSH_000333	9.36e-20	82.4	COG5007@1|root,COG5007@2|Bacteria,1R3MK@1224|Proteobacteria,1SE4M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the BolA IbaG family	SN15_13775	-	-	-	-	-	-	-	-	-	-	-	BolA
k59_80211_1	525897.Dbac_2183	2.97e-55	183.0	COG0464@1|root,COG0464@2|Bacteria,1QFHD@1224|Proteobacteria,42QEP@68525|delta/epsilon subdivisions,2WIT4@28221|Deltaproteobacteria,2M9XS@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,DUF4032
k59_788385_1	552811.Dehly_1614	7.41e-112	331.0	COG0530@1|root,COG0530@2|Bacteria,2G6GV@200795|Chloroflexi	200795|Chloroflexi	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_177777_1	330214.NIDE2929	4.84e-297	825.0	COG0465@1|root,COG0465@2|Bacteria,3J0AG@40117|Nitrospirae	2|Bacteria	D	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	3.4.21.53	ko:K03798,ko:K04076,ko:K13525,ko:K17681	ko04141,ko05134,map04141,map05134	M00400,M00403,M00742	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03019,ko03029,ko03110,ko04131,ko04147	3.A.16.1	-	-	AAA,FtsH_ext,Peptidase_M41
k59_993349_1	1123320.KB889629_gene7811	4.48e-69	215.0	COG2159@1|root,COG2159@2|Bacteria,2I9QG@201174|Actinobacteria	201174|Actinobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_47109_1	1121403.AUCV01000031_gene2857	9e-98	304.0	29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria,431AV@68525|delta/epsilon subdivisions,2WWN5@28221|Deltaproteobacteria,2MNY5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_961623_1	62928.azo1163	1.25e-33	122.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2VJ19@28216|Betaproteobacteria,2KV78@206389|Rhodocyclales	206389|Rhodocyclales	G	to the hyi family	hfi	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
k59_961623_2	948106.AWZT01000002_gene6289	8.19e-90	280.0	COG3960@1|root,COG3960@2|Bacteria,1MV88@1224|Proteobacteria,2VHT9@28216|Betaproteobacteria,1JZR7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the TPP enzyme family	gcl	-	4.1.1.47	ko:K01608	ko00630,ko01100,map00630,map01100	-	R00013	RC00899	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_47112_1	306281.AJLK01000062_gene4996	4.46e-27	102.0	COG2329@1|root,COG2329@2|Bacteria,1G7DQ@1117|Cyanobacteria,1JIXE@1189|Stigonemataceae	1117|Cyanobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_862805_1	582744.Msip34_0310	2.56e-23	91.3	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2VU2G@28216|Betaproteobacteria,2KN30@206350|Nitrosomonadales	206350|Nitrosomonadales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_733161_1	420662.Mpe_A1422	1.87e-57	192.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,1KJDV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	UPF0761 membrane protein	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_762739_1	1458275.AZ34_06480	6.13e-25	102.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VPM0@28216|Betaproteobacteria,4ACTH@80864|Comamonadaceae	28216|Betaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_762739_2	375286.mma_1291	8.96e-38	137.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VJTU@28216|Betaproteobacteria,477DI@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_210082_1	349124.Hhal_2231	3.57e-12	70.5	COG0300@1|root,COG0300@2|Bacteria,1RGKZ@1224|Proteobacteria,1T1HV@1236|Gammaproteobacteria,1X2QM@135613|Chromatiales	135613|Chromatiales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_145242_1	1131553.JIBI01000007_gene1140	1.28e-52	182.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,3721E@32003|Nitrosomonadales	28216|Betaproteobacteria	K	ribonuclease II	rnb	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
k59_120873_2	1122603.ATVI01000009_gene2593	2.01e-82	256.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1X4P2@135614|Xanthomonadales	135614|Xanthomonadales	S	Phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
k59_970206_2	330214.NIDE1649	4.56e-94	288.0	2AAUK@1|root,3107C@2|Bacteria,3J1E0@40117|Nitrospirae	40117|Nitrospirae	S	LPP20 lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
k59_314751_1	365046.Rta_30570	1.81e-16	81.3	2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,2VWJH@28216|Betaproteobacteria,4AF49@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306
k59_314751_2	257310.BB2119	5.88e-12	66.6	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,3T668@506|Alcaligenaceae	28216|Betaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
k59_410855_1	330214.NIDE0420	3.85e-73	230.0	COG0079@1|root,COG0079@2|Bacteria,3J0XY@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1023045_1	1231185.BAMP01000009_gene2274	1.95e-59	199.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2U3A6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_1001390_1	1229487.AMYW01000005_gene241	1.35e-10	62.0	COG4225@1|root,COG4225@2|Bacteria,4NIET@976|Bacteroidetes,1I0HZ@117743|Flavobacteriia,2NTC2@237|Flavobacterium	976|Bacteroidetes	S	Domain of unknown function (DUF4861)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4861
k59_1001390_2	518766.Rmar_2303	1.61e-176	507.0	COG1904@1|root,COG1904@2|Bacteria,4NFHS@976|Bacteroidetes	976|Bacteroidetes	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
k59_709316_1	991905.SL003B_3848	4.94e-120	350.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2VFQ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	leucine-zipper of insertion element IS481	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k59_741708_1	565034.BHWA1_02394	2.78e-46	167.0	COG4666@1|root,COG4666@2|Bacteria,2J57Z@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_88712_1	1283283.ATXA01000006_gene1743	1.02e-12	70.1	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria,4ESI9@85013|Frankiales	201174|Actinobacteria	K	ECF sigma factor	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_23196_1	1242864.D187_004512	2.92e-39	143.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2YVR0@29|Myxococcales	28221|Deltaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_277797_1	29495.EA26_15585	4.93e-60	196.0	COG3039@1|root,COG3039@2|Bacteria,1Q9AW@1224|Proteobacteria,1RNU1@1236|Gammaproteobacteria,1XZ6Q@135623|Vibrionales	135623|Vibrionales	L	IR of VSa6	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_349042_1	1121405.dsmv_2240	1.8e-63	196.0	arCOG10385@1|root,32SEM@2|Bacteria,1N1IG@1224|Proteobacteria,42TMW@68525|delta/epsilon subdivisions,2WQBW@28221|Deltaproteobacteria,2MK19@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	dsrJ	-	-	-	-	-	-	-	-	-	-	-	-
k59_349042_2	1121405.dsmv_2239	2.37e-31	119.0	COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,42MNU@68525|delta/epsilon subdivisions,2WJRG@28221|Deltaproteobacteria,2MIME@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	dsrO	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
k59_676532_1	1229909.NSED_06845	2.9e-108	322.0	COG0644@1|root,arCOG00570@2157|Archaea,41SB5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_839873_2	156889.Mmc1_0794	1.46e-21	86.7	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2UF3C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	tusA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_247565_1	983917.RGE_27460	3.06e-70	225.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,1KKAN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_578335_1	1304883.KI912532_gene2789	3.61e-55	181.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,2KVGE@206389|Rhodocyclales	206389|Rhodocyclales	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_871120_1	933262.AXAM01000005_gene2478	1.85e-07	57.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N0F@68525|delta/epsilon subdivisions,2WJAE@28221|Deltaproteobacteria,2MIUP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CZB,HAMP,MCPsignal
k59_871120_2	234267.Acid_5368	7.94e-26	100.0	COG0835@1|root,COG0835@2|Bacteria,3Y4YS@57723|Acidobacteria	57723|Acidobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
k59_380875_1	1305737.JAFX01000001_gene2689	4.66e-75	236.0	COG2911@1|root,COG2911@2|Bacteria,4NHAF@976|Bacteroidetes,47T04@768503|Cytophagia	976|Bacteroidetes	S	COG NOG10142 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	Porin_2
k59_410869_1	85643.Tmz1t_3475	6.23e-163	474.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,2KVV7@206389|Rhodocyclales	206389|Rhodocyclales	J	glutaminyl-tRNA	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_741727_1	1232410.KI421426_gene1459	2.62e-37	139.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42PGM@68525|delta/epsilon subdivisions,2X5J8@28221|Deltaproteobacteria,43SW4@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_791724_1	1158292.JPOE01000005_gene849	1.35e-83	262.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2VIFN@28216|Betaproteobacteria,1KJQY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	FAD dependent oxidoreductase	ordL	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
k59_741730_1	880072.Desac_2736	1.52e-91	292.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MR1B@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CoA binding domain	acs	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_120909_1	765911.Thivi_2664	3.31e-34	127.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,1SHHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_185643_1	330214.NIDE1222	1.78e-10	62.8	COG5000@1|root,COG5000@2|Bacteria,3J0B7@40117|Nitrospirae	40117|Nitrospirae	T	GHKL domain	-	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS
k59_185643_2	330214.NIDE1221	4.47e-31	112.0	2EAFJ@1|root,334IY@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
k59_741734_1	401526.TcarDRAFT_2709	9.76e-05	49.7	COG1566@1|root,COG1566@2|Bacteria,1V53J@1239|Firmicutes,4H26R@909932|Negativicutes	909932|Negativicutes	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	HlyD_D23
k59_446322_1	1380355.JNIJ01000010_gene1458	2.5e-25	106.0	COG0609@1|root,COG1120@1|root,COG0609@2|Bacteria,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2TV55@28211|Alphaproteobacteria,3JY8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_446322_2	748247.AZKH_0484	4.08e-145	414.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2VJQG@28216|Betaproteobacteria,2KUXA@206389|Rhodocyclales	206389|Rhodocyclales	H	Bacterial extracellular solute-binding protein	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k59_610460_1	1038858.AXBA01000003_gene4244	3.85e-90	275.0	COG0687@1|root,COG0687@2|Bacteria,1PRWU@1224|Proteobacteria,2U2MI@28211|Alphaproteobacteria,3EYWY@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
k59_23228_1	713587.THITH_04905	1.82e-85	280.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_610463_1	944435.AXAJ01000003_gene4120	6.02e-142	412.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2VIEM@28216|Betaproteobacteria,1K1V0@119060|Burkholderiaceae	28216|Betaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_610463_2	1266925.JHVX01000004_gene1298	8.31e-37	135.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,371UM@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	odhL	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_791728_2	160488.PP_1361	1.94e-63	210.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1YUY5@136845|Pseudomonas putida group	1236|Gammaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009987,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019058,GO:0019068,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0044183,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0097159,GO:0097367,GO:0101031,GO:1901265,GO:1901363,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_741749_1	945713.IALB_0610	4.62e-75	237.0	COG0621@1|root,COG0621@2|Bacteria	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_218201_1	925409.KI911562_gene579	2.25e-30	118.0	COG0436@1|root,COG0436@2|Bacteria,4NES3@976|Bacteroidetes,1IP0R@117747|Sphingobacteriia	976|Bacteroidetes	E	PFAM Aminotransferase class I and II	ybdL	-	2.6.1.88	ko:K14287	-	-	R08618	RC00006,RC00025	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_247592_2	543728.Vapar_4715	6.8e-52	167.0	COG0662@1|root,COG0662@2|Bacteria,1RH1E@1224|Proteobacteria,2VSQU@28216|Betaproteobacteria,4AEEV@80864|Comamonadaceae	28216|Betaproteobacteria	G	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_247592_3	1038866.KB902780_gene3913	6.71e-16	76.3	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2TR02@28211|Alphaproteobacteria,3JR2G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	MA20_00800	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_610474_1	1149133.ppKF707_3010	2.16e-36	142.0	28PH1@1|root,32DEN@2|Bacteria,1PHQF@1224|Proteobacteria,1TBFI@1236|Gammaproteobacteria,1YHC0@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_23240_1	436308.Nmar_0034	5.71e-65	210.0	COG2512@1|root,arCOG00374@2157|Archaea,41SUX@651137|Thaumarchaeota	651137|Thaumarchaeota	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_185669_1	1124983.PFLCHA0_c52970	5.15e-40	147.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1YP96@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	iECO103_1326.ECO103_1114	MVIN
k59_349096_2	339670.Bamb_5901	4.41e-08	53.5	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2VRUP@28216|Betaproteobacteria,1K6GB@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	ko:K15060	ko00627,ko01120,map00627,map01120	-	R09275	RC00392,RC01533	ko00000,ko00001	-	-	-	Rieske
k59_709388_1	745014.OMB55_00003810	8.22e-84	263.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1233 Phytoene dehydrogenase and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_642821_1	314607.KB13_1097	2.66e-13	67.4	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VRPJ@28216|Betaproteobacteria,1KQRJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_642821_2	1131553.JIBI01000039_gene1931	4.48e-83	266.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,372MQ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_446357_1	1122951.ATUE01000009_gene418	3.03e-96	299.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,3NJC9@468|Moraxellaceae	1236|Gammaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_88781_1	1163617.SCD_n02235	1.06e-71	219.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,2VRAZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0178 family	yaiI	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
k59_741778_1	1110502.TMO_2116	4.53e-89	272.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,2U4U5@28211|Alphaproteobacteria,2JZ8A@204441|Rhodospirillales	28211|Alphaproteobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_88785_1	436308.Nmar_0466	3.87e-36	131.0	arCOG08732@1|root,arCOG08732@2157|Archaea,41SR6@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_535383_1	985255.APHJ01000016_gene2943	4.61e-17	77.4	2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,1I02M@117743|Flavobacteriia	976|Bacteroidetes	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_410925_1	879212.DespoDRAFT_02660	1.59e-51	178.0	COG3385@1|root,COG3385@2|Bacteria,1NNH0@1224|Proteobacteria	1224|Proteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_446369_1	1123288.SOV_5c02360	1.33e-35	137.0	COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,4H7WA@909932|Negativicutes	909932|Negativicutes	F	Permease family	-	-	-	-	-	-	-	-	-	-	-	-	Xan_ur_permease
k59_937656_1	519989.ECTPHS_00355	2.34e-84	266.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1WXDW@135613|Chromatiales	135613|Chromatiales	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_610508_1	1177181.T9A_01360	2.16e-39	144.0	28HEE@1|root,2Z7QU@2|Bacteria,1MXU6@1224|Proteobacteria,1RZSJ@1236|Gammaproteobacteria,1XNV1@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain of unknown function (DUF932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF932
k59_1001478_1	570967.JMLV01000002_gene1872	4.3e-86	279.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPV8@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1042 Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_277843_2	3988.XP_002534960.1	8e-81	252.0	COG0740@1|root,KOG0840@2759|Eukaryota,37J0P@33090|Viridiplantae,3GCKS@35493|Streptophyta,4JFF1@91835|fabids	35493|Streptophyta	O	ATP-dependent Clp protease proteolytic subunit	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_513126_1	517417.Cpar_0058	1.21e-38	147.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1FESR@1090|Chlorobi	1090|Chlorobi	KT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,Sigma54_activat
k59_475955_1	582744.Msip34_0934	2.73e-68	226.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,2KKXI@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_535955_1	382464.ABSI01000005_gene1396	2.07e-69	231.0	COG1501@1|root,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	yihQ	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016798,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777,GO:1990929	3.2.1.177,3.2.1.199	ko:K01811,ko:K15922	-	-	R00802,R11543	RC00028,RC00059,RC00077,RC00451	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
k59_938702_1	1307761.L21SP2_0220	1.12e-25	103.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.72	ko:K00571,ko:K03497	-	-	-	-	ko00000,ko01000,ko02048,ko03000,ko03036,ko04812	-	-	-	N6_N4_Mtase,ParBc,RE_Eco29kI
k59_938702_2	945713.IALB_3102	1e-33	124.0	COG3358@1|root,COG3358@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
k59_24300_1	637389.Acaty_m0093	1.83e-34	128.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,rve
k59_903768_2	1121918.ARWE01000001_gene2286	4.94e-14	70.5	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2WMJ5@28221|Deltaproteobacteria,43S93@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_742867_1	1205680.CAKO01000002_gene2546	1.09e-88	274.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_742867_2	795666.MW7_3082	1.16e-49	172.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHND@28216|Betaproteobacteria,1K2B3@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_579522_1	1452718.JBOY01000004_gene3111	7.85e-71	222.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Hydrolase	yrfG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
k59_226204_2	686578.AFFX01000012_gene2070	5.94e-39	138.0	COG1028@1|root,COG1028@2|Bacteria,1QTUD@1224|Proteobacteria,1T1HG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	acdS	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	adh_short
k59_750499_1	861299.J421_5672	4.88e-131	397.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH,Glyco_hydro_63
k59_978941_1	118173.KB235914_gene4231	5.34e-43	150.0	COG3293@1|root,COG3293@2|Bacteria,1FZVT@1117|Cyanobacteria,1HDEX@1150|Oscillatoriales	1117|Cyanobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_587121_1	1304883.KI912532_gene504	4.49e-18	82.4	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,2KVN6@206389|Rhodocyclales	206389|Rhodocyclales	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_587121_2	1000565.METUNv1_03420	1.15e-30	110.0	COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,2KWZM@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the UPF0250 family	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
k59_750503_1	945713.IALB_0582	5.74e-22	93.2	COG2870@1|root,COG2870@2|Bacteria	2|Bacteria	H	ADP-L-glycero-beta-D-manno-heptose biosynthetic process	rfaE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_750503_2	1191523.MROS_1875	8.37e-45	149.0	COG0615@1|root,COG0615@2|Bacteria	2|Bacteria	H	ADP-L-glycero-beta-D-manno-heptose biosynthetic process	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_650927_1	1047013.AQSP01000113_gene741	2.71e-87	274.0	COG1070@1|root,COG1070@2|Bacteria,2NQ9W@2323|unclassified Bacteria	2|Bacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	1.1.1.57,2.7.1.17	ko:K00040,ko:K00854,ko:K19168	ko00040,ko01100,map00040,map01100	M00014,M00061	R01639,R02454	RC00002,RC00085,RC00538	ko00000,ko00001,ko00002,ko01000,ko02048	-	-	-	FGGY_C,FGGY_N
k59_322390_1	323848.Nmul_A0700	1.01e-81	245.0	COG0822@1|root,COG0822@2|Bacteria,1PC9F@1224|Proteobacteria,2VS65@28216|Betaproteobacteria,372KK@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_322390_2	1500893.JQNB01000001_gene185	3.75e-14	71.6	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1X4J9@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_388825_1	1380355.JNIJ01000001_gene3939	8.11e-51	170.0	COG1638@1|root,COG1638@2|Bacteria,1MXUZ@1224|Proteobacteria,2TTTA@28211|Alphaproteobacteria,3JR1D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	MA20_17110	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_388825_2	331869.BAL199_20315	1.26e-33	129.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,4BQDS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_685242_1	926550.CLDAP_26600	8.15e-18	85.9	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2G5VK@200795|Chloroflexi	200795|Chloroflexi	E	glutamate synthase, alpha subunit domain protein	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_9,GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_910752_1	261292.Nit79A3_1577	2.76e-79	251.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,2VUMQ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_618676_1	322710.Avin_04640	5.21e-33	129.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_618676_2	1080067.BAZH01000028_gene1309	1.42e-07	53.1	COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,1RN30@1236|Gammaproteobacteria,3WVZ7@544|Citrobacter	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	yfgF	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008081,GO:0008150,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0031224,GO:0033554,GO:0034059,GO:0034599,GO:0034614,GO:0035690,GO:0036293,GO:0036294,GO:0042221,GO:0042493,GO:0042542,GO:0042578,GO:0043900,GO:0044425,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070301,GO:0070482,GO:0070887,GO:0071111,GO:0071236,GO:0071453,GO:0071454,GO:0071944,GO:0097237,GO:1900190,GO:1901700,GO:1901701	-	-	-	-	-	-	-	-	-	-	EAL,MASE1
k59_879270_1	1121405.dsmv_2181	1.85e-84	260.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2MI44@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_226233_1	591157.SSLG_04201	6.56e-34	127.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
k59_97313_1	1266925.JHVX01000002_gene960	4.76e-41	150.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,373WQ@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
k59_910761_1	706587.Desti_0196	6.07e-105	311.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42QRU@68525|delta/epsilon subdivisions,2WMNQ@28221|Deltaproteobacteria,2MQDJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM ABC transporter	-	-	-	ko:K02049,ko:K15578,ko:K15579	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17	-	-	ABC_tran
k59_587149_1	1163617.SCD_n01403	5.67e-94	285.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria	28216|Betaproteobacteria	S	2-Nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
k59_97318_1	1249627.D779_2627	6.38e-41	147.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_97318_2	1123236.KB899376_gene1249	2.88e-15	75.9	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,464A9@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	mltD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1009450_1	927677.ALVU02000001_gene925	1.63e-54	194.0	COG3322@1|root,COG3852@1|root,COG5001@1|root,COG3322@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria	1117|Cyanobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS_3,PAS_4,PAS_9
k59_750533_1	96561.Dole_2657	5.64e-57	199.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_521814_1	710687.KI912270_gene5969	5.77e-20	92.4	COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,232UY@1762|Mycobacteriaceae	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_848671_1	1286631.X805_12670	4.32e-102	302.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,1KJJK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_63098_1	1232683.ADIMK_1900	1.39e-52	183.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RM8E@1236|Gammaproteobacteria,469IV@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_946198_1	1229909.NSED_09870	4.73e-86	261.0	COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_97334_1	1454004.AW11_00042	2.84e-43	158.0	COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_97334_2	314285.KT71_10052	1.49e-50	170.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1J8AR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_794960_1	436308.Nmar_0004	1.65e-54	179.0	COG3794@1|root,arCOG02926@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
k59_539733_1	1116369.KB890024_gene4104	1.84e-66	213.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TSIV@28211|Alphaproteobacteria,43I25@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	fructose-bisphosphate aldolase	fbaB	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_685278_1	269799.Gmet_3127	4.68e-56	197.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,43TI4@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_650967_1	518766.Rmar_1978	1.15e-25	111.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_388876_2	330214.NIDE0619	6.49e-198	553.0	COG2826@1|root,COG2826@2|Bacteria	2|Bacteria	L	transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_650974_1	1123073.KB899243_gene569	5.27e-13	68.6	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1X4P1@135614|Xanthomonadales	135614|Xanthomonadales	O	Cytochrome C biogenesis	ccmF1	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_650974_2	1454004.AW11_02930	2.5e-65	203.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1KQQX@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_650974_3	1348635.BBJY01000007_gene186	8.81e-05	43.1	COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,1XYX8@135623|Vibrionales	135623|Vibrionales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmD	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
k59_650974_4	1165096.ARWF01000001_gene1605	6.76e-32	118.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
k59_129327_1	411464.DESPIG_02498	9.7e-35	130.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2M8Q4@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_129327_2	1121405.dsmv_1856	2.21e-10	65.1	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WTRA@28221|Deltaproteobacteria,2MMYZ@213118|Desulfobacterales	28221|Deltaproteobacteria	O	MreB/Mbl protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_322442_1	391625.PPSIR1_32512	2.01e-55	185.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2WKM7@28221|Deltaproteobacteria,2YVBI@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	nifR3	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_31610_1	761193.Runsl_0112	1.47e-21	95.5	COG4314@1|root,COG4314@2|Bacteria,4NIPU@976|Bacteroidetes,47NSZ@768503|Cytophagia	976|Bacteroidetes	C	lipoprotein involved in nitrous oxide reduction	-	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
k59_418352_1	93220.LV28_07185	8.07e-20	89.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2VKVZ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	abc-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_418352_2	420324.KI912036_gene2593	8.11e-09	56.2	2DMMM@1|root,32SHA@2|Bacteria,1N257@1224|Proteobacteria,2TRFF@28211|Alphaproteobacteria,1JWEH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_777601_1	640081.Dsui_0434	1.75e-67	218.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,2KU6W@206389|Rhodocyclales	206389|Rhodocyclales	J	ribonuclease, Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
k59_777601_2	1123354.AUDR01000012_gene1747	7.47e-11	63.2	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQS@28216|Betaproteobacteria,1KRAZ@119069|Hydrogenophilales	119069|Hydrogenophilales	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
k59_946214_1	1348657.M622_11920	2.29e-105	313.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,2KUMZ@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_322447_1	933262.AXAM01000016_gene188	1.27e-49	175.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,42N95@68525|delta/epsilon subdivisions,2WJ0N@28221|Deltaproteobacteria,2MIKM@213118|Desulfobacterales	28221|Deltaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_322447_2	96561.Dole_2069	6.35e-12	64.3	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales	28221|Deltaproteobacteria	N	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
k59_946221_1	523791.Kkor_1345	1.45e-173	495.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RMUK@1236|Gammaproteobacteria,1XI0Y@135619|Oceanospirillales	135619|Oceanospirillales	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_129344_1	857087.Metme_0557	1.64e-12	67.4	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1XEZQ@135618|Methylococcales	135618|Methylococcales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_129344_2	1387312.BAUS01000004_gene1550	9.31e-48	161.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2VHD7@28216|Betaproteobacteria,2KKK7@206350|Nitrosomonadales	206350|Nitrosomonadales	O	PFAM 20S proteasome A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
k59_910812_1	945713.IALB_3092	7.9e-68	219.0	COG0232@1|root,COG0232@2|Bacteria	2|Bacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	iJN678.dgt	HD,HD_assoc
k59_750588_1	1123368.AUIS01000007_gene2749	4.95e-71	240.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,2NBUJ@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_685311_1	153948.NAL212_2215	4.95e-56	197.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MX4K@1224|Proteobacteria,2WB11@28216|Betaproteobacteria,373UZ@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM TonB-dependent receptor, beta-barrel	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_717943_2	1144312.PMI09_04874	3.82e-34	121.0	COG2044@1|root,COG2044@2|Bacteria,1RGAZ@1224|Proteobacteria,2UBFX@28211|Alphaproteobacteria,4BEWP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_193978_1	1123073.KB899244_gene294	1.38e-15	81.3	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1X3BD@135614|Xanthomonadales	135614|Xanthomonadales	E	Transglutaminase/protease-like homologues	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_194652_1	926569.ANT_14350	1.07e-44	149.0	COG1610@1|root,COG1610@2|Bacteria,2G7B8@200795|Chloroflexi	200795|Chloroflexi	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_651668_1	246196.MSMEI_4308	6.66e-17	76.6	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,2339H@1762|Mycobacteriaceae	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008113,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0016491,GO:0016667,GO:0016671,GO:0020012,GO:0030682,GO:0033744,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0075136	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_226960_1	196490.AUEZ01000007_gene5116	9.27e-30	115.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,3JWN0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_226960_2	1205680.CAKO01000010_gene3898	7.56e-28	112.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,2JR5U@204441|Rhodospirillales	204441|Rhodospirillales	E	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_63817_2	192875.XP_004342842.1	2.03e-35	133.0	COG4799@1|root,KOG0540@2759|Eukaryota,38D8D@33154|Opisthokonta	33154|Opisthokonta	EI	propionyl-CoA carboxylase activity	PCCB	GO:0003674,GO:0003824,GO:0004658,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006520,GO:0006629,GO:0006631,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009063,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0051186,GO:0070013,GO:0071704,GO:0072329,GO:1901360,GO:1901564,GO:1901565,GO:1901575	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_162506_1	395495.Lcho_1113	1.04e-16	77.0	COG3090@1|root,COG3090@2|Bacteria,1R7QD@1224|Proteobacteria,2VQ1H@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctQ	-	-	-	ko:K21394	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctQ
k59_162506_2	614083.AWQR01000002_gene2966	5.8e-97	292.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VKC6@28216|Betaproteobacteria,4AC8C@80864|Comamonadaceae	28216|Betaproteobacteria	G	TRAP dicarboxylate transporter	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
k59_778205_1	138119.DSY4131	1.78e-21	97.8	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,263I8@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_389743_1	243231.GSU3082	7.23e-36	126.0	2DTBN@1|root,33JKH@2|Bacteria,1NBVZ@1224|Proteobacteria,42XUQ@68525|delta/epsilon subdivisions,2WTFT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_483693_1	1191523.MROS_0693	2.19e-64	216.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_226976_1	1123392.AQWL01000002_gene2030	1.48e-11	60.5	COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,1KTD2@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Protein of unknown function (DUF493)	-	-	-	-	-	-	-	-	-	-	-	-	DUF493
k59_226976_2	265072.Mfla_2498	2.6e-62	201.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,2KNF4@206350|Nitrosomonadales	206350|Nitrosomonadales	EH	Amino-transferase class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_63832_1	338963.Pcar_1256	1.18e-62	203.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,43T3I@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_255611_1	1121920.AUAU01000004_gene684	1.72e-27	117.0	COG1566@1|root,COG1566@2|Bacteria,3Y53G@57723|Acidobacteria	57723|Acidobacteria	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_483697_1	1049564.TevJSym_ac00090	6.46e-106	320.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,1RQ8F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Nitrous oxidase accessory protein	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
k59_323162_1	1131814.JAFO01000001_gene2890	1.5e-82	249.0	COG1225@1|root,COG1225@2|Bacteria,1MWJP@1224|Proteobacteria,2TSSW@28211|Alphaproteobacteria,3F1G4@335928|Xanthobacteraceae	28211|Alphaproteobacteria	O	Redoxin	MA20_36550	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
k59_194688_1	443143.GM18_2543	6.16e-07	51.2	292XF@1|root,2ZQEX@2|Bacteria,1P8W2@1224|Proteobacteria,432F4@68525|delta/epsilon subdivisions,2WXUJ@28221|Deltaproteobacteria,43VN9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
k59_795248_1	1121405.dsmv_2788	1.24e-12	67.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,2MIMF@213118|Desulfobacterales	28221|Deltaproteobacteria	J	PFAM ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
k59_418988_1	314278.NB231_12896	1.1e-74	245.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW7H@135613|Chromatiales	135613|Chromatiales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_949342_2	582744.Msip34_0291	6.91e-68	211.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2VHDK@28216|Betaproteobacteria,2KKGN@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_394107_1	886293.Sinac_6462	1.1e-88	270.0	COG0451@1|root,COG0451@2|Bacteria,2IX7V@203682|Planctomycetes	203682|Planctomycetes	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_329060_1	1192868.CAIU01000003_gene232	4.98e-47	160.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,43QFN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	ko:K22303	-	-	-	-	ko00000,ko01000	-	-	-	TauD
k59_753026_1	743719.PaelaDRAFT_3568	1.59e-18	90.5	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,4HBJM@91061|Bacilli,26RX4@186822|Paenibacillaceae	91061|Bacilli	H	Belongs to the folylpolyglutamate synthase family	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_361570_2	153948.NAL212_3100	0.00022	43.5	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2VNAX@28216|Betaproteobacteria,372BP@32003|Nitrosomonadales	28216|Betaproteobacteria	I	PFAM Phospholipid glycerol acyltransferase	nlaB	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_883827_1	358823.DF19_11225	1.24e-26	108.0	COG1028@1|root,COG1028@2|Bacteria,2GP5U@201174|Actinobacteria	201174|Actinobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_165929_1	391596.PBAL39_09531	7.06e-11	66.2	COG0635@1|root,COG0635@2|Bacteria,4NFEE@976|Bacteroidetes,1IR75@117747|Sphingobacteriia	976|Bacteroidetes	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_557806_2	436308.Nmar_1707	3.05e-78	236.0	COG0125@1|root,arCOG01891@2157|Archaea,41T33@651137|Thaumarchaeota	651137|Thaumarchaeota	F	thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_426935_1	580332.Slit_2287	8.55e-49	162.0	2E3EJ@1|root,32YDJ@2|Bacteria,1N8MS@1224|Proteobacteria,2VW4J@28216|Betaproteobacteria,44WH3@713636|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_426935_2	1502852.FG94_03535	6.12e-14	73.6	COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,2VH3D@28216|Betaproteobacteria,472X8@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	A domain family that is part of the cupin metalloenzyme superfamily.	ycfD	-	1.14.11.47	ko:K18850	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Cupin_4
k59_557807_1	675812.VHA_002186	1.7e-21	90.1	COG3090@1|root,COG3090@2|Bacteria,1RBHY@1224|Proteobacteria,1S5RE@1236|Gammaproteobacteria,1XXPI@135623|Vibrionales	135623|Vibrionales	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_557807_2	1238450.VIBNISOn1_560142	1.35e-21	94.0	COG1593@1|root,COG1593@2|Bacteria,1MUHY@1224|Proteobacteria,1RYC3@1236|Gammaproteobacteria,1XTXZ@135623|Vibrionales	135623|Vibrionales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_394126_1	196367.JNFG01000204_gene443	3.27e-11	62.4	COG2184@1|root,COG2184@2|Bacteria,1RAVF@1224|Proteobacteria,2VRNI@28216|Betaproteobacteria,1KF1V@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
k59_394126_2	1121022.ABENE_20935	5.51e-28	108.0	COG3655@1|root,COG3655@2|Bacteria,1QZZC@1224|Proteobacteria,2TYVV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_851324_1	713587.THITH_01405	6.06e-17	79.7	2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,1RRV2@1236|Gammaproteobacteria,1WXVA@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_133347_1	1000565.METUNv1_02207	7.19e-91	285.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,2KUV3@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_720953_1	870187.Thini_1771	2.68e-52	182.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,462AI@72273|Thiotrichales	72273|Thiotrichales	P	PFAM von Willebrand factor type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	-
k59_720953_2	671143.DAMO_0173	1.16e-19	80.5	2E3CN@1|root,32YBX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_525051_1	1123024.AUII01000035_gene1220	1.19e-74	248.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4DZUH@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_981780_1	264732.Moth_0729	7.89e-75	239.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,42EKW@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_68101_1	1535287.JP74_19305	3.56e-09	57.4	COG1129@1|root,COG1129@2|Bacteria,1MVNR@1224|Proteobacteria,2TTCM@28211|Alphaproteobacteria,3N7SM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056,ko:K10545	ko02010,map02010	M00215,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.4	-	-	ABC_tran
k59_68101_2	1100721.ALKO01000022_gene1883	3.46e-11	66.6	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VJN3@28216|Betaproteobacteria,4AC7N@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1013185_1	345073.VC395_0340	6.12e-09	56.2	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1XWV0@135623|Vibrionales	135623|Vibrionales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_1013185_2	1265313.HRUBRA_02568	6.63e-55	176.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1J5YM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0560	DHquinase_II
k59_917007_1	1463825.JNXC01000080_gene5387	1.51e-37	141.0	COG5659@1|root,COG5659@2|Bacteria,2GIU9@201174|Actinobacteria,4E456@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_590400_1	1120999.JONM01000001_gene1485	3.88e-79	264.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria	28216|Betaproteobacteria	G	carbohydrate binding	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_557837_1	1282876.BAOK01000001_gene3045	4.5e-26	111.0	COG0841@1|root,COG0841@2|Bacteria,1R2RN@1224|Proteobacteria,2TZQG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_426971_1	768671.ThimaDRAFT_0960	2.43e-19	82.4	2DMKI@1|root,32S70@2|Bacteria,1N1FV@1224|Proteobacteria,1THVW@1236|Gammaproteobacteria,1WZR5@135613|Chromatiales	135613|Chromatiales	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
k59_426971_2	335543.Sfum_1953	6.04e-20	88.2	COG1940@1|root,COG1940@2|Bacteria,1NFM0@1224|Proteobacteria,42SQD@68525|delta/epsilon subdivisions,2WPSD@28221|Deltaproteobacteria,2MRQ2@213462|Syntrophobacterales	28221|Deltaproteobacteria	GK	ROK family	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_949395_1	977880.RALTA_A1802	7.44e-74	234.0	COG0683@1|root,COG0683@2|Bacteria,1N1MX@1224|Proteobacteria,2VJMT@28216|Betaproteobacteria,1KGRT@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_784454_1	378806.STAUR_5173	7.79e-33	117.0	COG3411@1|root,COG3411@2|Bacteria,1RM68@1224|Proteobacteria,42TUK@68525|delta/epsilon subdivisions,2WQGU@28221|Deltaproteobacteria,2YVQK@29|Myxococcales	28221|Deltaproteobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_784454_2	671143.DAMO_1607	2.27e-10	60.5	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	iPC815.YPO2896,iYL1228.KPN_02862	Aminotran_5
k59_394158_1	1299327.I546_5452	5.19e-93	282.0	COG0451@1|root,COG0451@2|Bacteria,2I9DG@201174|Actinobacteria,237C3@1762|Mycobacteriaceae	201174|Actinobacteria	GM	NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_329090_1	1162668.LFE_0345	4.09e-20	90.1	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
k59_329090_3	648757.Rvan_0595	2.65e-46	151.0	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,2U9K5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_329090_8	1357714.A0A067XQ33_9CAUD	2.85e-79	251.0	4QBAP@10239|Viruses,4QVX8@35237|dsDNA viruses  no RNA stage,4QQZ1@28883|Caudovirales,4QJTG@10662|Myoviridae	10662|Myoviridae	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_949402_2	428125.CLOLEP_01423	1.06e-45	158.0	2E2JP@1|root,32XP4@2|Bacteria,1VAIM@1239|Firmicutes,24PPR@186801|Clostridia,3WI4W@541000|Ruminococcaceae	186801|Clostridia	S	Phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Sipho_tail
k59_688506_1	926569.ANT_26660	1.66e-22	88.6	COG0234@1|root,COG0234@2|Bacteria,2G6WW@200795|Chloroflexi	200795|Chloroflexi	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_688506_2	926569.ANT_26670	4.11e-72	232.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi	200795|Chloroflexi	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_590416_1	926550.CLDAP_40590	9.72e-49	171.0	COG0535@1|root,COG2002@1|root,COG0535@2|Bacteria,COG2002@2|Bacteria,2G75Y@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
k59_525095_1	520709.F985_01778	4.94e-18	82.8	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,3NKE6@468|Moraxellaceae	1236|Gammaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	icd	GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144	Iso_dh
k59_525095_2	926569.ANT_22170	6.93e-41	139.0	COG2009@1|root,COG2009@2|Bacteria,2G7CW@200795|Chloroflexi	200795|Chloroflexi	C	succinate dehydrogenase, cytochrome	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_492613_1	796620.VIBC2010_17210	4.69e-17	84.7	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,1RPKH@1236|Gammaproteobacteria,1XSIQ@135623|Vibrionales	1236|Gammaproteobacteria	S	protein conserved in bacteria	VP1651	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_819112_1	477228.YO5_10210	8.65e-63	209.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1Z1W2@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	clsC	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0090483,GO:1901576	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_819112_2	1345023.M467_15460	3.83e-21	86.7	COG1226@1|root,COG1226@2|Bacteria,1VCJJ@1239|Firmicutes,4HM5T@91061|Bacilli	91061|Bacilli	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_917047_1	522306.CAP2UW1_1498	1.76e-54	181.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,1KPQA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_917047_2	748280.NH8B_2263	5.36e-12	65.9	COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,2KSQP@206351|Neisseriales	206351|Neisseriales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,Condensation,PP-binding
k59_165988_1	1122180.Lokhon_01595	8.29e-27	103.0	2C5R9@1|root,32VFY@2|Bacteria,1N0MI@1224|Proteobacteria,2UDWW@28211|Alphaproteobacteria,2P9TX@245186|Loktanella	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_2652_1	666681.M301_0333	7.9e-95	296.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,2KMC8@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_981833_1	380394.Lferr_2175	3.92e-25	97.1	COG0509@1|root,COG0509@2|Bacteria,1N2U9@1224|Proteobacteria,1SC71@1236|Gammaproteobacteria,2NCVY@225057|Acidithiobacillales	225057|Acidithiobacillales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_199328_2	1232410.KI421413_gene517	1.96e-14	75.1	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,43RX8@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Translation-initiation factor 2	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_493370_1	1278309.KB907101_gene518	6.96e-51	171.0	COG1714@1|root,COG1714@2|Bacteria,1RIE9@1224|Proteobacteria,1S566@1236|Gammaproteobacteria,1XK0Q@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_264684_1	1191523.MROS_1812	3.09e-38	135.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_819848_1	1408418.JNJH01000191_gene642	1.4e-12	70.5	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_819848_2	653733.Selin_2484	2.15e-51	176.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_689243_1	1266925.JHVX01000004_gene1219	4.95e-75	236.0	COG0385@1|root,COG0385@2|Bacteria,1PWDU@1224|Proteobacteria,2WBYI@28216|Betaproteobacteria,3740W@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Sodium Bile acid symporter family	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	-
k59_199340_1	342113.DM82_2681	1.34e-63	207.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,1K1KV@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_656591_1	580332.Slit_2233	1.15e-105	336.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,44UYD@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_721758_1	1217718.ALOU01000083_gene2975	4.4e-38	140.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,1K1V2@119060|Burkholderiaceae	28216|Betaproteobacteria	C	formate dehydrogenase	fdhC	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_166722_1	640081.Dsui_2182	9.82e-69	223.0	COG0477@1|root,COG2814@2|Bacteria,1QUTR@1224|Proteobacteria,2VHHN@28216|Betaproteobacteria,2KZXW@206389|Rhodocyclales	206389|Rhodocyclales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_460083_1	1547437.LL06_00240	1.61e-67	212.0	COG0684@1|root,COG0684@2|Bacteria,1QSHP@1224|Proteobacteria,2U948@28211|Alphaproteobacteria,43K4G@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
k59_329847_1	1163617.SCD_n02871	4.91e-32	122.0	COG3307@1|root,COG3307@2|Bacteria,1NGAP@1224|Proteobacteria,2VY7V@28216|Betaproteobacteria	28216|Betaproteobacteria	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
k59_950206_1	1279019.ARQK01000059_gene970	1.64e-66	221.0	COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1X0CC@135613|Chromatiales	135613|Chromatiales	E	7 transmembrane helices usually fused to an inactive transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	7TM_transglut,Transglut_i_TM
k59_3452_1	1163617.SCD_n01213	1.93e-84	258.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria	28216|Betaproteobacteria	M	VacJ family lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_3452_2	1453503.AU05_23110	2.03e-09	58.5	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1YDZ3@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Catalyzes the formation of succinate from succinate semialdehyde	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_982579_1	566466.NOR53_3183	4.4e-67	219.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria	1224|Proteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_329864_1	1384054.N790_13945	1.63e-37	133.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1X4HD@135614|Xanthomonadales	135614|Xanthomonadales	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_329864_2	62928.azo0766	8.51e-35	129.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2VHK7@28216|Betaproteobacteria,2KVC3@206389|Rhodocyclales	206389|Rhodocyclales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_36165_1	105559.Nwat_2897	1.79e-74	237.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales	135613|Chromatiales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_656630_1	323848.Nmul_A2422	2.11e-77	240.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,372GT@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_721798_1	266264.Rmet_1512	4.73e-103	304.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,2VHZD@28216|Betaproteobacteria,1K4M9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Phosphoribulokinase	cbbP	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_3474_1	497964.CfE428DRAFT_2857	1.02e-67	228.0	COG3523@1|root,COG3523@2|Bacteria,46VI0@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ImcF-related N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ImcF-related_N
k59_721800_1	1131553.JIBI01000005_gene2210	3.7e-48	158.0	COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria,3737B@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_721800_2	292415.Tbd_2207	1.28e-06	53.5	COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,2VKUS@28216|Betaproteobacteria,1KSX4@119069|Hydrogenophilales	119069|Hydrogenophilales	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2
k59_689294_1	391615.ABSJ01000022_gene315	2.44e-35	131.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1J5ZU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_269668_2	1163617.SCD_n00229	4.65e-63	205.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_367305_1	1410620.SHLA_15c000700	3.74e-18	80.1	2AEUU@1|root,314S7@2|Bacteria,1PYXE@1224|Proteobacteria,2V2UE@28211|Alphaproteobacteria,4BJMV@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3277
k59_987482_1	566466.NOR53_1768	1.26e-17	85.9	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1J962@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Cytidylyltransferase family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_1596,iSDY_1059.SDY_0191	CTP_transf_1
k59_106517_1	595537.Varpa_1346	3.39e-47	166.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4AAHM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_235498_2	626887.J057_07291	1.92e-52	173.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,1T1GE@1236|Gammaproteobacteria,4670C@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Integral membrane protein TerC family	ygdQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TerC
k59_955423_1	1207063.P24_02231	6.81e-22	95.9	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria,2JPDE@204441|Rhodospirillales	204441|Rhodospirillales	S	AFG1-like ATPase	-	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
k59_955423_2	767434.Fraau_1672	8.14e-13	68.9	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1X33P@135614|Xanthomonadales	135614|Xanthomonadales	C	Quinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_922937_2	930169.B5T_03771	5.62e-97	287.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1XI4I@135619|Oceanospirillales	135619|Oceanospirillales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_922937_3	1336245.JAGO01000014_gene1248	1.29e-09	58.2	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales	135619|Oceanospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_857048_1	278963.ATWD01000001_gene2074	1.17e-16	79.0	COG0533@1|root,COG0533@2|Bacteria,3Y2PN@57723|Acidobacteria,2JHJ0@204432|Acidobacteriia	204432|Acidobacteriia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_857048_2	497964.CfE428DRAFT_2715	1.12e-23	101.0	COG0793@1|root,COG0793@2|Bacteria,46SM7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_498579_1	1538295.JY96_14280	2.31e-66	216.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1KJ65@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxyl transferase domain	accB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_498579_2	1071679.BG57_09610	1.31e-11	64.3	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VN0R@28216|Betaproteobacteria,1K2NT@119060|Burkholderiaceae	28216|Betaproteobacteria	C	oxidoreductase	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_661793_1	1249627.D779_3787	9.56e-13	68.6	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1WXBU@135613|Chromatiales	135613|Chromatiales	P	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_cB
k59_661793_2	1163617.SCD_n01155	1.65e-82	249.0	COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,2VP9C@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_563755_1	338969.Rfer_4176	4.9e-55	188.0	COG2271@1|root,COG2271@2|Bacteria,1R8Q1@1224|Proteobacteria,2VKPK@28216|Betaproteobacteria,4ABJB@80864|Comamonadaceae	28216|Betaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_889271_1	243231.GSU1099	1.75e-98	296.0	COG0226@1|root,COG0226@2|Bacteria,1PVGI@1224|Proteobacteria,43A46@68525|delta/epsilon subdivisions,2X1XS@28221|Deltaproteobacteria,43VRM@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	-
k59_694504_1	288000.BBta_1460	6.29e-108	331.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_726962_1	945713.IALB_2343	2.47e-29	118.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	ppiD	-	5.2.1.8	ko:K01802,ko:K03769,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
k59_955442_1	330214.NIDE3756	2.23e-106	318.0	COG0845@1|root,COG0845@2|Bacteria,3J15V@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	HlyD_D23
k59_726968_1	197221.22294129	1.62e-73	235.0	COG0161@1|root,COG0161@2|Bacteria,1G1QE@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.18,2.6.1.62	ko:K00822,ko:K00833	ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100	M00123,M00573,M00577	R00907,R03231,R04187	RC00006,RC00008,RC00062,RC00160,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_955445_1	948106.AWZT01000054_gene1530	3.53e-111	353.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1K1A9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_171803_2	1165841.SULAR_03382	1.65e-24	97.4	COG1266@1|root,COG1266@2|Bacteria,1ND7U@1224|Proteobacteria	1224|Proteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1015940_1	402881.Plav_1782	3.87e-64	209.0	COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2TRWW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P-450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_528263_1	1229909.NSED_02835	8.67e-33	119.0	COG0580@1|root,arCOG04431@2157|Archaea,41S5R@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Major Intrinsic Protein	-	-	-	ko:K06188,ko:K09866	ko04962,ko04976,map04962,map04976	-	-	-	ko00000,ko00001,ko02000	1.A.8	-	-	MIP
k59_528263_2	436308.Nmar_0560	2.92e-96	281.0	COG1225@1|root,arCOG00310@2157|Archaea,41SN5@651137|Thaumarchaeota	651137|Thaumarchaeota	O	AhpC/TSA antioxidant enzyme	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_563788_1	330214.NIDE4183	1.69e-107	318.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	tdh	-	1.1.1.103,2.7.13.3	ko:K00060,ko:K07777	ko00260,ko02020,map00260,map02020	M00478	R01465	RC00525	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	ADH_N,ADH_zinc_N
k59_628759_1	1121035.AUCH01000002_gene1718	5.29e-110	330.0	COG2199@1|root,COG3706@2|Bacteria,1N7HG@1224|Proteobacteria,2VPE2@28216|Betaproteobacteria,2KUP8@206389|Rhodocyclales	206389|Rhodocyclales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_74156_1	1123072.AUDH01000009_gene463	2.01e-23	101.0	COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,2VFQZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_41163_1	1123278.KB893427_gene1235	1.79e-52	181.0	2AQ5P@1|root,31FB4@2|Bacteria,4NRIU@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_889292_1	1347086.CCBA010000030_gene124	4.84e-20	86.3	COG0791@1|root,COG0791@2|Bacteria,1VX13@1239|Firmicutes,4HX2B@91061|Bacilli,1ZIFC@1386|Bacillus	91061|Bacilli	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
k59_889292_2	1218084.BBJK01000135_gene7223	1.84e-310	856.0	COG0492@1|root,COG0492@2|Bacteria,1MVX2@1224|Proteobacteria,2VM3V@28216|Betaproteobacteria,1K4AE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
k59_661836_1	323848.Nmul_A0742	1.04e-181	533.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,371WK@32003|Nitrosomonadales	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_41171_2	887898.HMPREF0551_1957	1.28e-78	257.0	COG3596@1|root,COG3596@2|Bacteria,1R01T@1224|Proteobacteria,2WHSI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF3482)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3482,MMR_HSR1
k59_528777_2	1125863.JAFN01000001_gene3242	2.55e-42	148.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	mccA	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016002,GO:0016043,GO:0016491,GO:0016667,GO:0017144,GO:0019748,GO:0020037,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044272,GO:0044550,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051259,GO:0051260,GO:0055114,GO:0065003,GO:0070206,GO:0070207,GO:0070813,GO:0070814,GO:0071840,GO:0097159,GO:1901363,GO:1903136	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1
k59_988514_1	281687.CJA21249b	8.34e-16	71.6	2DF3V@1|root,2S5RJ@2759|Eukaryota,3AARI@33154|Opisthokonta,3BTYV@33208|Metazoa,3DBCA@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_368365_1	243231.GSU0201	5.36e-61	208.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,42NU9@68525|delta/epsilon subdivisions,2WKXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2,Fer2,Fer2_2
k59_597293_1	640081.Dsui_3408	5.87e-12	66.2	2BW01@1|root,32RUH@2|Bacteria,1N665@1224|Proteobacteria,2VVCA@28216|Betaproteobacteria,2KWYH@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_924046_1	439235.Dalk_4977	2.2e-70	224.0	COG0443@1|root,COG0443@2|Bacteria,1P7BK@1224|Proteobacteria,42PNW@68525|delta/epsilon subdivisions,2WKSX@28221|Deltaproteobacteria,2MHUK@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PRTRC system protein D	-	-	-	ko:K18640	-	-	-	-	ko00000,ko04812	-	-	-	-
k59_564866_1	1123508.JH636448_gene7536	3.98e-43	152.0	COG3541@1|root,COG3541@2|Bacteria,2IXJ3@203682|Planctomycetes	203682|Planctomycetes	S	Predicted nucleotidyltransferase	-	-	-	ko:K07074	-	-	-	-	ko00000	-	-	-	Nuc-transf
k59_140289_1	1120983.KB894577_gene3579	2.44e-88	266.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2U6JP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_140289_2	1120983.KB894577_gene3578	5.79e-24	100.0	COG0673@1|root,COG0673@2|Bacteria,1PGFP@1224|Proteobacteria,2V8DN@28211|Alphaproteobacteria,1JQA3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_107656_1	196367.JNFG01000016_gene3976	4.31e-19	85.9	COG0662@1|root,COG0662@2|Bacteria,1RHN1@1224|Proteobacteria	1224|Proteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_924069_1	748247.AZKH_1530	1.14e-93	286.0	COG0642@1|root,COG2205@2|Bacteria,1QV1H@1224|Proteobacteria,2WGTQ@28216|Betaproteobacteria,2KVWB@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_75217_1	1123392.AQWL01000005_gene2885	4.23e-85	285.0	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,2VIKY@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_9876_1	95619.PM1_0217365	3.75e-100	321.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_302781_1	269799.Gmet_1305	1.24e-22	93.6	COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,42VJM@68525|delta/epsilon subdivisions,2WRBG@28221|Deltaproteobacteria,43UVC@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	PFAM ROSMUCR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ROS_MUCR
k59_597331_1	62928.azo3488	1.23e-19	85.9	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales	206389|Rhodocyclales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
k59_597331_2	556268.OFAG_00615	3e-38	138.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,4725J@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_107663_2	316067.Geob_0575	2.25e-52	185.0	COG4269@1|root,COG4269@2|Bacteria,1MW5P@1224|Proteobacteria,42R97@68525|delta/epsilon subdivisions,2WMRA@28221|Deltaproteobacteria,43TIH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF898)	-	-	-	-	-	-	-	-	-	-	-	-	DUF898
k59_662887_1	522306.CAP2UW1_0299	8.53e-30	122.0	COG2202@1|root,COG3829@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KQH8@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_9
k59_988566_1	999141.GME_03542	2.56e-78	241.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1XI7T@135619|Oceanospirillales	135619|Oceanospirillales	S	ABC transporter ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_786628_1	1454004.AW11_01648	1.17e-60	194.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2VIJ5@28216|Betaproteobacteria,1KQMB@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase, C-terminal domain	yibF	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
k59_988568_1	1000565.METUNv1_03434	2.03e-18	81.6	COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,2VU9I@28216|Betaproteobacteria,2KZF6@206389|Rhodocyclales	206389|Rhodocyclales	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
k59_988568_2	652103.Rpdx1_3853	6.21e-38	132.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2TTXE@28211|Alphaproteobacteria,3JQRN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_597343_1	272123.Anacy_1661	4.01e-24	106.0	COG0642@1|root,COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria,1HISH@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,Response_reg
k59_236479_1	105559.Nwat_2819	7.03e-126	374.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1X0J9@135613|Chromatiales	135613|Chromatiales	P	PFAM Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_662901_1	1541065.JRFE01000004_gene5329	1.51e-26	104.0	COG3415@1|root,COG3415@2|Bacteria,1G6I1@1117|Cyanobacteria,3VN4B@52604|Pleurocapsales	1117|Cyanobacteria	L	Homeodomain-like domain	-	-	-	ko:K07499	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_32,HTH_33
k59_336043_1	398525.KB900701_gene2460	3.81e-93	283.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TSIV@28211|Alphaproteobacteria,3JVD2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Fructose-bisphosphate aldolase class-I	fbaB	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_786629_1	1131553.JIBI01000005_gene2227	1.46e-99	310.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,371SD@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_433607_1	335543.Sfum_3497	9.48e-131	389.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_826200_1	436308.Nmar_1120	1.73e-97	310.0	COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_9907_1	1548151.LS70_03200	2.2e-17	84.7	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,43B2E@68525|delta/epsilon subdivisions,2YN33@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	peptidylprolyl isomerase	peb4	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_464908_1	395493.BegalDRAFT_2525	2.42e-35	137.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,463KB@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_890302_1	1485544.JQKP01000002_gene1357	2.41e-13	72.0	COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,2WGMC@28216|Betaproteobacteria,44V6B@713636|Nitrosomonadales	28216|Betaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_42266_1	1150474.JQJI01000002_gene1150	5.44e-44	158.0	COG0297@1|root,COG0297@2|Bacteria,2GC9U@200918|Thermotogae	200918|Thermotogae	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	iLJ478.TM0895	Glyco_transf_5,Glycos_transf_1
k59_662918_1	375286.mma_1973	4.36e-54	189.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,472MV@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
k59_140332_1	1123368.AUIS01000004_gene125	2.42e-67	219.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,2NCIC@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_924100_1	706587.Desti_4219	5e-126	369.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2WJD7@28221|Deltaproteobacteria,2MQ5Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Na+-transporting oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k59_826217_2	179408.Osc7112_3813	4.08e-31	125.0	COG1131@1|root,COG5373@1|root,COG1131@2|Bacteria,COG5373@2|Bacteria,1G11U@1117|Cyanobacteria,1H8ET@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_629854_1	323848.Nmul_A2343	4.75e-68	214.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,372XM@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Squalene/phytoene synthase	hpnD	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_728136_1	357804.Ping_1235	2.9e-75	244.0	COG0754@1|root,COG3942@1|root,COG0754@2|Bacteria,COG3942@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Glutathionylspermidine synthase	gsp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008884,GO:0008885,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016880,GO:0044424,GO:0044444,GO:0044464	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3484	CHAP,GSP_synth
k59_788828_1	7897.ENSLACP00000004557	2.8e-61	208.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A2BJ@33154|Opisthokonta,3BR1K@33208|Metazoa,3D7JS@33213|Bilateria,48GGU@7711|Chordata,49DSU@7742|Vertebrata	33208|Metazoa	K	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,Exo_endo_phos_2
k59_211323_1	1167006.UWK_00135	1.45e-62	218.0	COG0745@1|root,COG4191@1|root,COG5000@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ29@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,dCache_3
k59_763761_1	1463864.JOGO01000130_gene2711	2.97e-20	95.5	COG0174@1|root,COG0174@2|Bacteria,2GJ83@201174|Actinobacteria	201174|Actinobacteria	E	glutamine synthetase	glnA3	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N_2
k59_635858_2	395494.Galf_1685	2.11e-17	83.2	COG1450@1|root,COG1450@2|Bacteria,1NC06@1224|Proteobacteria,2VR15@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Bacterial type II and III secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,Secretin_N
k59_342106_1	251221.35212216	6.63e-54	177.0	COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria	1117|Cyanobacteria	J	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_211328_1	314271.RB2654_06719	0.000224	44.3	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
k59_896167_1	1123487.KB892835_gene3664	4.84e-83	246.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2VR8I@28216|Betaproteobacteria,2KW6N@206389|Rhodocyclales	206389|Rhodocyclales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_702061_1	330214.NIDE4133	2.22e-102	320.0	COG0532@1|root,COG0532@2|Bacteria,3J0CC@40117|Nitrospirae	40117|Nitrospirae	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_146474_1	457425.XNR_5802	1.11e-08	58.5	COG1123@1|root,COG4172@2|Bacteria,2I3AG@201174|Actinobacteria	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
k59_146474_2	1168059.KB899087_gene762	2.08e-10	65.9	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,3EZ5R@335928|Xanthobacteraceae	28211|Alphaproteobacteria	Q	MlaD protein	MA20_08125	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_832617_1	296591.Bpro_1844	7.62e-40	140.0	COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2VRGI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
k59_832617_2	236097.ADG881_1331	4.85e-14	70.9	COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,1XHZG@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
k59_896173_1	883126.HMPREF9710_05067	1.07e-46	152.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2VSJ2@28216|Betaproteobacteria,4748X@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
k59_896173_2	631362.Thi970DRAFT_03826	6.74e-10	58.2	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1WY1A@135613|Chromatiales	135613|Chromatiales	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
k59_274333_1	1219035.NT2_08_01320	3.39e-70	222.0	COG2141@1|root,COG2141@2|Bacteria,1MWDV@1224|Proteobacteria,2TV51@28211|Alphaproteobacteria,2K3NY@204457|Sphingomonadales	204457|Sphingomonadales	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_506650_1	1163617.SCD_n00075	2.05e-96	300.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Amp-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_309142_1	1238182.C882_4240	5.85e-29	108.0	COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,2UETR@28211|Alphaproteobacteria,2JU90@204441|Rhodospirillales	204441|Rhodospirillales	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_309142_2	1121937.AUHJ01000004_gene965	3.33e-32	114.0	COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,1SE40@1236|Gammaproteobacteria,468Q3@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	mnhF	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_864900_1	85643.Tmz1t_0549	2.73e-78	252.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,2KVP5@206389|Rhodocyclales	206389|Rhodocyclales	I	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_764474_1	765913.ThidrDRAFT_3274	2.21e-123	365.0	COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_833430_1	1249627.D779_0178	4.79e-127	377.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1WW7B@135613|Chromatiales	135613|Chromatiales	C	reductase, alpha subunit	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_242191_1	439235.Dalk_2682	5.92e-61	204.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,42MYY@68525|delta/epsilon subdivisions,2WJ6V@28221|Deltaproteobacteria,2MI2N@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SpoVR like protein	spoVR	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
k59_375003_1	436308.Nmar_1695	2.98e-84	259.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
k59_833435_1	1123487.KB892863_gene1989	2.52e-63	207.0	COG1142@1|root,COG1142@2|Bacteria,1PPAS@1224|Proteobacteria,2W9FZ@28216|Betaproteobacteria,2KZD0@206389|Rhodocyclales	206389|Rhodocyclales	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_896866_1	396588.Tgr7_1023	6.93e-34	118.0	COG4327@1|root,COG4327@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4212)	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	DUF4212
k59_896866_2	1469245.JFBG01000027_gene1495	4.01e-45	160.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_764485_1	1120983.KB894572_gene2860	5.03e-89	270.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria,1JNHB@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Quinolinate synthetase A protein	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_114619_2	323848.Nmul_A2479	3.75e-48	159.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2VUH0@28216|Betaproteobacteria,373BU@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_571970_1	234267.Acid_6265	1.05e-39	153.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_963743_1	1266925.JHVX01000005_gene1865	7.66e-108	322.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,372QQ@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_670073_1	326427.Cagg_2818	1.91e-22	94.0	COG0274@1|root,COG0274@2|Bacteria,2G7HC@200795|Chloroflexi,375WJ@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
k59_604234_1	646529.Desaci_1080	7.2e-41	152.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,261B2@186807|Peptococcaceae	186801|Clostridia	KL	DNA helicase, Rad3	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
k59_636663_1	667014.Thein_0936	1.5e-29	113.0	COG1259@1|root,COG1259@2|Bacteria,2GH8I@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
k59_995366_1	639283.Snov_1916	4.32e-71	228.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases	lldD2	-	1.1.2.3,1.1.99.31	ko:K00101,ko:K15054	ko00620,ko00627,ko01100,ko01120,map00620,map00627,map01100,map01120	-	R00196,R04160,R07664	RC00044,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_242215_1	1121405.dsmv_3135	1.23e-125	372.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MHV2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_440285_2	768671.ThimaDRAFT_3686	1.29e-32	119.0	2E0F6@1|root,32W1G@2|Bacteria,1N6I3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_440285_3	555779.Dthio_PD3611	2.16e-196	562.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MGHZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_440285_4	1121405.dsmv_0889	1.11e-105	313.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NRE@68525|delta/epsilon subdivisions,2WM0E@28221|Deltaproteobacteria,2MJFH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_82332_1	582744.Msip34_0247	2e-56	187.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,2KKBV@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_405509_1	502025.Hoch_1127	6.67e-87	271.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales	28221|Deltaproteobacteria	H	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_212143_1	76114.p2A109	1.03e-89	278.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2W317@28216|Betaproteobacteria	1224|Proteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182,ko:K16874	ko00130,ko00365,ko01100,ko01110,ko01120,map00130,map00365,map01100,map01110,map01120	M00117	R04985,R04986,R10213	RC00391,RC03086	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_604250_1	436308.Nmar_0834	1.36e-26	101.0	arCOG10552@1|root,arCOG10552@2157|Archaea,41T8T@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_147347_1	1297570.MESS4_670041	4.65e-66	214.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_571996_1	1127673.GLIP_0764	1.42e-40	153.0	COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,1RRTY@1236|Gammaproteobacteria,4685K@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Peptidase M50	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_735332_1	1283300.ATXB01000002_gene2925	1.18e-199	575.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XE1B@135618|Methylococcales	135618|Methylococcales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_309207_2	1163617.SCD_n00055	4.57e-27	107.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,2VIKX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
k59_212171_1	1120956.JHZK01000042_gene3051	9.6e-112	342.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,1JQ5T@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_342962_1	338969.Rfer_3955	7.7e-06	47.0	COG0550@1|root,COG5531@1|root,COG0550@2|Bacteria,COG5531@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,4AAE2@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA topoisomerase, type IA, central domain protein	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
k59_342962_2	864051.BurJ1DRAFT_0250	2.08e-59	187.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2VR5U@28216|Betaproteobacteria,1KKW9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cysteine-rich motif following a subset of SET domains	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
k59_470652_1	396588.Tgr7_0340	3.46e-111	345.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1WWPF@135613|Chromatiales	135613|Chromatiales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_896909_1	1163617.SCD_n02124	9.28e-29	107.0	COG4967@1|root,COG4967@2|Bacteria,1N7AC@1224|Proteobacteria,2VW8B@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	type IV pilus modification protein PilV	-	-	-	ko:K02671	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
k59_896909_2	395494.Galf_0170	5.65e-35	127.0	COG4970@1|root,COG4970@2|Bacteria,1NA9B@1224|Proteobacteria,2VV1S@28216|Betaproteobacteria,44W1X@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	Type II transport protein GspH	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_82365_1	113395.AXAI01000042_gene6040	1.13e-23	99.8	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JYHD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_114670_1	644282.Deba_1250	1.56e-45	152.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_470653_2	383372.Rcas_2537	6.11e-08	53.9	COG0577@1|root,COG0577@2|Bacteria,2G68F@200795|Chloroflexi,376ZY@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_636702_1	1229909.NSED_09430	4.69e-128	384.0	arCOG02322@1|root,arCOG07810@1|root,arCOG02322@2157|Archaea,arCOG07810@2157|Archaea,41T0S@651137|Thaumarchaeota	651137|Thaumarchaeota	N	Adenylate guanylate cyclase with integral membrane sensor	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HAMP
k59_670122_1	126957.SMAR010554-PA	1.55e-09	58.9	KOG2853@1|root,KOG2853@2759|Eukaryota,38ZPZ@33154|Opisthokonta,3B96U@33208|Metazoa,3CXNE@33213|Bilateria,41YB9@6656|Arthropoda	33208|Metazoa	S	Oxidoreductase activity. It is involved in the biological process described with oxidation-reduction process	FOXRED1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009987,GO:0010257,GO:0016020,GO:0016043,GO:0016491,GO:0019866,GO:0022607,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0055114,GO:0065003,GO:0070469,GO:0071840,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204	-	ko:K18166	-	-	-	-	ko00000,ko03029	-	-	-	DAO
k59_670122_2	1232437.KL661971_gene4894	1.46e-56	187.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,42SUF@68525|delta/epsilon subdivisions,2WPJU@28221|Deltaproteobacteria,2MKU8@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_735346_1	1458357.BG58_05605	8.8e-89	284.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2VJZW@28216|Betaproteobacteria,1K3Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
k59_931243_1	1123399.AQVE01000009_gene3147	6.02e-30	121.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,460N8@72273|Thiotrichales	72273|Thiotrichales	NU	TIGRFAM FimV C-terminal domain	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
k59_342978_1	1121937.AUHJ01000017_gene3028	4.52e-42	142.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
k59_572028_1	887327.HMPREF0476_1354	3.17e-55	184.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2VIC9@28216|Betaproteobacteria,2KQBB@206351|Neisseriales	206351|Neisseriales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_506747_1	886293.Sinac_0990	3.91e-49	175.0	COG0072@1|root,COG0072@2|Bacteria,2IX0Q@203682|Planctomycetes	203682|Planctomycetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_702985_1	765914.ThisiDRAFT_0268	5.46e-110	329.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WWGR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_963806_1	264198.Reut_A1315	4.29e-15	77.8	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2VIC1@28216|Betaproteobacteria,1K1S3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ABC transporter	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_735358_1	498761.HM1_0854	2.03e-15	74.3	COG0311@1|root,COG0311@2|Bacteria,1V3I6@1239|Firmicutes,24HRT@186801|Clostridia	186801|Clostridia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
k59_735358_2	555088.DealDRAFT_2161	2.42e-90	273.0	COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,248C1@186801|Clostridia,42JR1@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
k59_995434_1	243233.MCA0127	1.09e-119	357.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPN9@1236|Gammaproteobacteria,1XEME@135618|Methylococcales	135618|Methylococcales	S	pfam abc	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_342991_2	1392838.AWNM01000025_gene4209	2.18e-49	170.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJCY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_506767_1	748658.KB907316_gene493	9.81e-111	332.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_343003_1	1123354.AUDR01000015_gene354	1.08e-78	262.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KSFJ@119069|Hydrogenophilales	119069|Hydrogenophilales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_246973_2	1235457.C404_12830	1.22e-52	167.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2VSDV@28216|Betaproteobacteria,1K8CG@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_246973_3	1288494.EBAPG3_21520	1.59e-178	516.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,371N6@32003|Nitrosomonadales	28216|Betaproteobacteria	C	chain 5 L	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_675796_1	237368.SCABRO_02892	6.32e-100	308.0	28HMZ@1|root,2Z7WD@2|Bacteria,2J2EK@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_676632_1	1231391.AMZF01000094_gene118	2.25e-50	174.0	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_218256_1	1526927.Plano_2087	2.84e-19	92.4	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,4HASP@91061|Bacilli,26DRM@186818|Planococcaceae	91061|Bacilli	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_277849_1	1380394.JADL01000014_gene153	5.37e-136	413.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JP8A@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_871211_1	580332.Slit_1884	2.17e-79	248.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,44VKW@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_153669_2	314285.KT71_17316	2.99e-67	214.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1J80N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroG	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_0684,iECSF_1327.ECSF_0680,iEcSMS35_1347.EcSMS35_0777,iLF82_1304.LF82_0146,iNRG857_1313.NRG857_03335,iYL1228.KPN_00758	DAHP_synth_1
k59_475970_1	886293.Sinac_3820	1.36e-66	213.0	COG2141@1|root,COG2141@2|Bacteria,2J10P@203682|Planctomycetes	203682|Planctomycetes	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1001503_2	1040986.ATYO01000025_gene1377	1.44e-16	75.5	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2UF4X@28211|Alphaproteobacteria,43KTI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the	yciI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_902809_1	1120999.JONM01000002_gene841	1.35e-34	133.0	COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,2KPVM@206351|Neisseriales	206351|Neisseriales	M	4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferase of PMT family K00754	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_185739_1	261292.Nit79A3_0577	2.93e-31	115.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,372W8@32003|Nitrosomonadales	28216|Betaproteobacteria	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
k59_185739_2	497321.C664_01600	2.01e-39	141.0	28I8W@1|root,2Z8BP@2|Bacteria,1N0SC@1224|Proteobacteria,2VK0J@28216|Betaproteobacteria,2KVDQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF2863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2863
k59_314865_1	1049564.TevJSym_ad00500	6.06e-101	311.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	phaD	-	1.6.5.3	ko:K00342,ko:K05561,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_535411_1	1122603.ATVI01000005_gene3040	4.77e-81	256.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_770097_2	671143.DAMO_0457	1.32e-38	143.0	COG1029@1|root,COG1029@2|Bacteria	2|Bacteria	-	-	fhcB	GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
k59_513165_1	1131553.JIBI01000036_gene2049	2.07e-90	277.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,3721F@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Sigma-54 interaction domain	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2
k59_871235_1	330214.NIDE4314	3.92e-68	216.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_871235_2	330214.NIDE4313	6.13e-100	294.0	COG0279@1|root,COG0279@2|Bacteria,3J0HG@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
k59_1001516_1	420246.GTNG_0051	9.78e-80	256.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4HA0A@91061|Bacilli,1WFQ2@129337|Geobacillus	91061|Bacilli	S	MazG nucleotide pyrophosphohydrolase domain	yabN	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
k59_791762_1	1340493.JNIF01000003_gene4564	6.49e-19	92.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	ubiG	-	2.1.1.222,2.1.1.294,2.1.1.64,2.7.1.181	ko:K00568,ko:K18827	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781,R10657,R10658	RC00002,RC00003,RC00078,RC00392,RC01895,RC03220	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_446420_1	153948.NAL212_0819	8.32e-17	79.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,371ZM@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.100,1.5.1.33	ko:K00059,ko:K03793	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_446420_2	265072.Mfla_0230	5.53e-23	97.1	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,2KKBV@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_970362_1	1449065.JMLL01000012_gene3738	2.25e-84	265.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2U1RU@28211|Alphaproteobacteria,43MQW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Predicted Permease Membrane Region	-	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex,TrkA_C
k59_937720_1	1397527.Q670_05870	2.37e-89	276.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1TJAF@1236|Gammaproteobacteria,1XP37@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_513178_1	1288494.EBAPG3_5930	2e-65	215.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,373DA@32003|Nitrosomonadales	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,Pkinase
k59_676679_1	1226322.HMPREF1545_03546	3.37e-14	77.8	COG2369@1|root,COG4695@1|root,COG2369@2|Bacteria,COG4695@2|Bacteria,1UGAT@1239|Firmicutes,24X7X@186801|Clostridia	186801|Clostridia	S	Phage Mu protein F like protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_Mu_F,Phage_portal
k59_218300_1	1485544.JQKP01000021_gene47	1.51e-98	306.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,44VFQ@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_446432_1	477184.KYC_24752	1.25e-29	120.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPYJ@28216|Betaproteobacteria,3T6MT@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_610570_1	402881.Plav_2964	4.24e-09	58.2	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,2TSJC@28211|Alphaproteobacteria,1JQ01@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Proton-conducting membrane transporter	nuoL3	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_610570_2	1126627.BAWE01000004_gene4069	2.43e-140	409.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,3JWB9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
k59_23347_1	485915.Dret_2298	2.83e-69	223.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MDPJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_902852_1	365046.Rta_15900	3.52e-59	192.0	COG1995@1|root,COG1995@2|Bacteria,1MXGJ@1224|Proteobacteria,2VISV@28216|Betaproteobacteria,4ABVP@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the PdxA family	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_741867_1	1125863.JAFN01000001_gene3522	1.13e-91	287.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_902855_1	1049564.TevJSym_bc00390	7.76e-79	250.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	hydB	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_902855_2	2340.JV46_26710	5.18e-20	85.1	2AB8D@1|root,310NU@2|Bacteria,1RFGC@1224|Proteobacteria,1S5A2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_381016_1	1123392.AQWL01000005_gene3218	2.67e-56	187.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,2VK76@28216|Betaproteobacteria,1KSUI@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_381016_2	1430440.MGMSRv2_3902	1.69e-92	276.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria,2JVPD@204441|Rhodospirillales	204441|Rhodospirillales	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11
k59_411005_1	690850.Desaf_3306	3.23e-29	114.0	COG3293@1|root,COG3293@2|Bacteria,1R5NV@1224|Proteobacteria,430FR@68525|delta/epsilon subdivisions,2WVKI@28221|Deltaproteobacteria,2MFEK@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_709498_1	91464.S7335_721	1.86e-138	400.0	COG3385@1|root,COG3385@2|Bacteria,1G3TU@1117|Cyanobacteria,1H2E0@1129|Synechococcus	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_5,DDE_Tnp_1
k59_578515_1	1265313.HRUBRA_01473	3.26e-119	359.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1J8WI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	AMP-binding enzyme	JD73_00810	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2,PP-binding
k59_446454_1	398578.Daci_1295	3.03e-31	122.0	COG3181@1|root,COG3181@2|Bacteria,1N1ND@1224|Proteobacteria,2VKD0@28216|Betaproteobacteria,4ABBA@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_709508_1	1163617.SCD_n01470	7.27e-81	268.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_937751_1	266265.Bxe_B0329	7.17e-58	201.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2VMAN@28216|Betaproteobacteria,1K3JX@119060|Burkholderiaceae	28216|Betaproteobacteria	CP	Proton-conducting membrane transporter	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_937751_2	75379.Tint_0284	2.02e-30	117.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2VKBD@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NADH dehydrogenase	hyfD	-	-	-	-	-	-	-	-	-	-	-	NADHdh
k59_277880_1	298654.FraEuI1c_1677	4.75e-14	70.5	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4ESJQ@85013|Frankiales	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_277880_2	945713.IALB_2192	6.25e-91	273.0	COG0540@1|root,COG0540@2|Bacteria	2|Bacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15490	OTCace,OTCace_N
k59_349214_1	1415780.JPOG01000001_gene1377	4.59e-55	190.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1X3EZ@135614|Xanthomonadales	135614|Xanthomonadales	L	Single-stranded-DNA-specific exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_642940_1	204669.Acid345_1900	1.18e-41	156.0	COG2936@1|root,COG2936@2|Bacteria,3Y6W3@57723|Acidobacteria	57723|Acidobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_709519_1	1193729.A1OE_1078	8.15e-11	58.9	COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2UBWN@28211|Alphaproteobacteria,2JU2A@204441|Rhodospirillales	204441|Rhodospirillales	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_709519_2	1229909.NSED_08035	2.07e-49	165.0	COG0720@1|root,arCOG02172@2157|Archaea,41SY8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_153741_1	1417296.U879_08035	3.21e-135	395.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_185810_1	338963.Pcar_0111	4.7e-81	254.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2WKSV@28221|Deltaproteobacteria,43U77@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,PAS
k59_902882_1	765420.OSCT_1950	1.37e-44	164.0	COG0457@1|root,COG0457@2|Bacteria,2G71Q@200795|Chloroflexi,376GZ@32061|Chloroflexia	32061|Chloroflexia	NU	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TPR_10,TPR_12,TPR_16,TPR_7
k59_185813_1	1415166.NONO_c50490	2.48e-05	48.9	COG4221@1|root,COG4221@2|Bacteria,2HA4H@201174|Actinobacteria,4G2MJ@85025|Nocardiaceae	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_185813_2	35754.JNYJ01000016_gene9279	2.83e-23	97.1	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4DDGP@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_153748_1	795666.MW7_2288	6e-56	180.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,1K6ZD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	ntpA	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
k59_1001575_1	1227453.C444_02286	1.69e-18	87.0	COG0613@1|root,arCOG00302@2157|Archaea,2XYHU@28890|Euryarchaeota,23WFP@183963|Halobacteria	183963|Halobacteria	S	metal-dependent phosphoesterases (PHP family)	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
k59_610623_1	580332.Slit_0706	6.57e-45	161.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,44VC0@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_610623_2	84751.XP_007880587.1	0.000294	44.3	COG0302@1|root,KOG2698@2759|Eukaryota,38CYY@33154|Opisthokonta,3NVRA@4751|Fungi,3UZMS@5204|Basidiomycota,3N2IW@452284|Ustilaginomycotina	4751|Fungi	H	GTP cyclohydrolase I	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006066,GO:0006082,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046394,GO:0046483,GO:0046655,GO:0046656,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iMM904.YGR267C,iND750.YGR267C	GTP_cyclohydroI
k59_55175_1	330214.NIDE3273	5.1e-23	91.7	COG1826@1|root,COG1826@2|Bacteria,3J1A4@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_55175_2	330214.NIDE3272	3.59e-119	350.0	COG3391@1|root,COG3391@2|Bacteria,3J19W@40117|Nitrospirae	40117|Nitrospirae	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
k59_770173_1	1131553.JIBI01000018_gene517	1.88e-39	150.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,371Z5@32003|Nitrosomonadales	28216|Betaproteobacteria	T	SMART Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_676748_1	595537.Varpa_1337	1.44e-65	211.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,2VJHU@28216|Betaproteobacteria,4A9S6@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_709560_1	1232410.KI421425_gene1552	5.88e-51	182.0	COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_741939_1	1121448.DGI_2572	0.000235	44.3	COG0314@1|root,COG0314@2|Bacteria,1N3AF@1224|Proteobacteria,42TPP@68525|delta/epsilon subdivisions,2WQK3@28221|Deltaproteobacteria,2MC27@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM molybdopterin biosynthesis MoaE protein	-	-	-	-	-	-	-	-	-	-	-	-	MoaE
k59_1001594_1	637389.Acaty_c0522	1.2e-15	75.9	2F2KZ@1|root,33VHM@2|Bacteria,1NV1E@1224|Proteobacteria,1SN95@1236|Gammaproteobacteria,2NCKP@225057|Acidithiobacillales	225057|Acidithiobacillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1001594_2	1121004.ATVC01000009_gene1002	1.21e-88	263.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,2VIDX@28216|Betaproteobacteria,2KPDE@206351|Neisseriales	206351|Neisseriales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_411059_1	395493.BegalDRAFT_0060	1.39e-43	147.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,1S44Q@1236|Gammaproteobacteria,463JT@72273|Thiotrichales	72273|Thiotrichales	K	NikR C terminal nickel binding domain	-	-	-	-	-	-	-	-	-	-	-	-	NikR_C,RHH_1
k59_218383_1	398525.KB900701_gene6702	3.19e-135	406.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_871331_1	1242864.D187_004287	2.12e-90	282.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42PZH@68525|delta/epsilon subdivisions,2WJ0T@28221|Deltaproteobacteria,2YTTX@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_578579_1	1095769.CAHF01000001_gene3462	8.63e-97	295.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,47348@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_902920_1	713586.KB900536_gene2578	3.83e-98	296.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
k59_247766_1	1229909.NSED_01285	9.35e-90	264.0	COG0377@1|root,arCOG01554@2157|Archaea,41S6D@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the complex I 20 kDa subunit family	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_55198_1	1458275.AZ34_06900	9.01e-79	248.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,4AAWB@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_153785_1	97138.C820_02496	2.24e-18	84.7	COG1573@1|root,COG1573@2|Bacteria,1V4M9@1239|Firmicutes,24C6M@186801|Clostridia,36E51@31979|Clostridiaceae	186801|Clostridia	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_871340_1	1208919.CDSE_0394	5.22e-30	114.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,1KPY7@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	DNA replication, recombination and repair	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_977792_1	436308.Nmar_0115	2.19e-130	384.0	COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_30414_1	1521187.JPIM01000034_gene3583	1.74e-106	323.0	COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi,3750X@32061|Chloroflexia	32061|Chloroflexia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_585953_1	573061.Clocel_1533	5.16e-18	85.5	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,36DD8@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
k59_585953_2	1095769.CAHF01000009_gene1397	2.42e-180	508.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4730X@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_453248_1	1459636.NTE_00079	4.51e-48	175.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
k59_281742_1	443143.GM18_2768	9.62e-76	246.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,42X93@68525|delta/epsilon subdivisions,2WSXR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_62006_1	443143.GM18_3541	1.02e-32	130.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_1026884_1	515635.Dtur_1427	1.07e-59	206.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	mpg	-	1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8	ko:K00344,ko:K00966,ko:K01840,ko:K03431,ko:K15778,ko:K16881	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00361,M00362	R00885,R00959,R01057,R01818,R02060,R08639	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3178	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
k59_847502_1	1121106.JQKB01000007_gene1070	9.38e-26	104.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2JV0E@204441|Rhodospirillales	204441|Rhodospirillales	E	Methionine synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_847502_2	358681.BBR47_56470	1.31e-27	110.0	COG1028@1|root,COG1028@2|Bacteria,1TS7Z@1239|Firmicutes,4HFZ6@91061|Bacilli	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	dhbA	-	1.1.1.100,1.1.1.385,1.3.1.28	ko:K00059,ko:K00216,ko:K19548	ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01130,ko01212,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01130,map01212	M00083,M00572,M00787	R01505,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R10917,R11671	RC00029,RC00117,RC00154,RC00534	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_749334_1	1121920.AUAU01000005_gene1056	1.47e-81	266.0	COG0247@1|root,COG0247@2|Bacteria,3Y3RK@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_749334_2	1304865.JAGF01000001_gene832	8.52e-10	60.8	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_749334_3	1288494.EBAPG3_26750	1.58e-37	133.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2VMWZ@28216|Betaproteobacteria,372M9@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_482110_1	716544.wcw_1472	2.55e-36	137.0	COG1250@1|root,COG1250@2|Bacteria,2JFTQ@204428|Chlamydiae	204428|Chlamydiae	C	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
k59_649885_1	63737.Npun_F3678	3.85e-74	247.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,Response_reg
k59_225162_1	765910.MARPU_04845	3.35e-68	226.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
k59_520509_1	268407.PWYN_13515	5.86e-31	120.0	COG0366@1|root,COG0366@2|Bacteria,1TR93@1239|Firmicutes,4HDDA@91061|Bacilli,275IY@186822|Paenibacillaceae	91061|Bacilli	G	Sucrose glucosyltransferase	gtfA	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_520509_2	1121396.KB893079_gene862	1.63e-32	126.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,42NCP@68525|delta/epsilon subdivisions,2WJSM@28221|Deltaproteobacteria,2MI5K@213118|Desulfobacterales	28221|Deltaproteobacteria	M	HAD-superfamily hydrolase, subfamily IIB	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_1008405_1	553385.JEMF01000037_gene2712	5.69e-45	153.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1XK2G@135619|Oceanospirillales	135619|Oceanospirillales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1008405_2	857087.Metme_4507	2.7e-06	48.5	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1XEKJ@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	-	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_977825_1	316057.RPD_1469	2.65e-85	268.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U2ES@28211|Alphaproteobacteria,3K6TU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_321374_1	1266925.JHVX01000009_gene103	6.21e-53	174.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,3725B@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_321374_2	1123073.KB899243_gene466	0.000125	43.5	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1X3X4@135614|Xanthomonadales	135614|Xanthomonadales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_749346_1	926569.ANT_02020	6.01e-142	406.0	COG1788@1|root,COG1788@2|Bacteria,2G6IM@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_776578_1	518766.Rmar_0923	3.56e-66	224.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1FIM5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EI	ArgK protein	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_945045_1	1121374.KB891575_gene869	3.44e-37	135.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P	epmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
k59_30456_1	439235.Dalk_4642	4.13e-06	47.8	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria,2MM4E@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_30456_2	330214.NIDE3067	8.79e-106	310.0	COG2884@1|root,COG2884@2|Bacteria,3J139@40117|Nitrospirae	40117|Nitrospirae	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_387677_1	571.MC52_04885	1.33e-07	52.0	COG4575@1|root,COG4575@2|Bacteria,1N6X7@1224|Proteobacteria,1S9QF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane protein YqjD	yqjD	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0043021,GO:0043024,GO:0044464,GO:0044877,GO:0060187,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF883
k59_482128_2	359.CN09_24620	6.56e-38	137.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,4BACT@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1026894_1	83406.HDN1F_02700	3.08e-13	69.3	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,1RPQA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	(ABC) transporter	yddA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
k59_1026894_2	187272.Mlg_0956	2.27e-27	110.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_453282_1	1095769.CAHF01000005_gene1469	1.98e-141	421.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria	28216|Betaproteobacteria	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_321382_1	76114.ebA2533	3.92e-66	220.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KUY0@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_160728_1	485915.Dret_0949	1.61e-40	144.0	2EGX7@1|root,33APC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_160728_2	745014.OMB55_00020010	8.42e-28	111.0	2DQBG@1|root,335T7@2|Bacteria,1R35T@1224|Proteobacteria	1224|Proteobacteria	S	Selenoprotein B glycine betaine sarcosine D-proline reductase	-	-	1.21.4.1	ko:K10794	ko00330,map00330	-	R02825	RC00790	ko00000,ko00001,ko01000	-	-	-	GRDB
k59_684142_1	519989.ECTPHS_08101	4.8e-58	202.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria,1X2II@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_482136_1	640512.BC1003_2674	3.36e-20	86.7	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,2VQ09@28216|Betaproteobacteria,1K33N@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_482136_2	1349767.GJA_1153	0.000113	44.7	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,472SY@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	helix_turn_helix isocitrate lyase regulation	yiaJ	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_909715_1	1123367.C666_07605	5.83e-33	121.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2VKKJ@28216|Betaproteobacteria,2KVUE@206389|Rhodocyclales	206389|Rhodocyclales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_909715_2	264198.Reut_A3037	4.49e-43	150.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,1K3VB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_794499_1	1201288.M900_A0045	6.63e-23	92.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2MT7G@213481|Bdellovibrionales,2WQ23@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_794499_2	946483.Cenrod_2052	9.49e-21	86.3	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,4ADZP@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM Thioredoxin domain	trxC	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
k59_321396_1	330214.NIDE2556	4.65e-68	213.0	COG2877@1|root,COG2877@2|Bacteria,3J0AK@40117|Nitrospirae	40117|Nitrospirae	M	DAHP synthetase I family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_321396_2	330214.NIDE2557	2.64e-113	335.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,3J0GG@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_539187_1	1255043.TVNIR_1306	4.44e-101	312.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_254025_1	330214.NIDE3850	3.08e-78	247.0	COG2403@1|root,COG2403@2|Bacteria	2|Bacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	cobW
k59_878249_1	1485544.JQKP01000002_gene1529	7.66e-104	315.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,44VAU@713636|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM membrane bound O-acyl transferase MBOAT family protein	pacA	-	-	-	-	-	-	-	-	-	-	-	MBOAT
k59_684166_1	1382359.JIAL01000001_gene2848	5.43e-131	387.0	COG1866@1|root,COG1866@2|Bacteria,3Y3U4@57723|Acidobacteria,2JKFR@204432|Acidobacteriia	204432|Acidobacteriia	C	Phosphoenolpyruvate carboxykinase	-	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_794500_2	101162.XP_007692543.1	1.44e-05	50.1	KOG4012@1|root,KOG4012@2759|Eukaryota,38FHA@33154|Opisthokonta,3P3ZN@4751|Fungi,3QWME@4890|Ascomycota,20297@147541|Dothideomycetes,4KF7R@92860|Pleosporales	4751|Fungi	B	Domain in histone families 1 and 5	-	GO:0000228,GO:0000793,GO:0000794,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0031974,GO:0031981,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0070013	-	ko:K11275	-	-	-	-	ko00000,ko03036	-	-	-	Linker_histone
k59_281779_1	247490.KSU1_C0085	1.26e-45	153.0	COG0225@1|root,COG0225@2|Bacteria,2IZ67@203682|Planctomycetes	203682|Planctomycetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_586040_1	580332.Slit_2233	2.51e-89	291.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,44UYD@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_749391_1	1157708.KB907458_gene1961	8.68e-73	248.0	COG2203@1|root,COG3614@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3614@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS,PAS_3
k59_417333_1	1454004.AW11_00172	3.41e-92	286.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,1KQF5@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_749393_2	40373.F991_03276	6.79e-19	86.7	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,3NJI3@468|Moraxellaceae	1236|Gammaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006083,GO:0006084,GO:0006085,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006473,GO:0006476,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016054,GO:0016405,GO:0016787,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018193,GO:0018205,GO:0018394,GO:0019213,GO:0019427,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033558,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034421,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043687,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045733,GO:0046390,GO:0046395,GO:0046483,GO:0050218,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072329,GO:0072521,GO:0072522,GO:0090407,GO:0098732,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iE2348C_1286.E2348C_4392,iYL1228.KPN_04478	ACAS_N,AMP-binding,AMP-binding_C
k59_356453_1	953739.SVEN_2279	1.31e-18	87.0	COG1309@1|root,COG1309@2|Bacteria,2GJPK@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_C_6,TetR_N
k59_749395_1	1249627.D779_2312	2.15e-103	317.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXUN@135613|Chromatiales	135613|Chromatiales	P	TrkA-C domain	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_586049_1	649831.L083_2761	6.19e-60	204.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4D8XJ@85008|Micromonosporales	201174|Actinobacteria	G	Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_776628_1	999541.bgla_1g00830	8.49e-96	289.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,1K08J@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_617667_1	640081.Dsui_3260	2.9e-71	234.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,2KV9E@206389|Rhodocyclales	206389|Rhodocyclales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_160773_1	1385521.N803_08165	1.74e-86	284.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4FEMU@85021|Intrasporangiaceae	201174|Actinobacteria	E	MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_586053_1	1163617.SCD_n00618	9.6e-88	287.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_30514_1	358220.C380_19325	1.14e-75	241.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_716871_1	1408418.JNJH01000054_gene406	3.47e-88	268.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,2JRJV@204441|Rhodospirillales	204441|Rhodospirillales	G	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_482184_1	1183438.GKIL_1844	1.25e-70	238.0	COG1452@1|root,COG1452@2|Bacteria,1G0TW@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Mannosyl oligosaccharide glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
k59_586059_1	395494.Galf_1186	1.17e-44	157.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,44V1A@713636|Nitrosomonadales	28216|Betaproteobacteria	T	MucB/RseB C-terminal domain	rseB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_539205_1	436308.Nmar_0620	3.48e-74	240.0	COG3356@1|root,arCOG04351@2157|Archaea,41S7S@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
k59_749413_2	1123487.KB892865_gene1564	1.06e-07	51.6	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,2KV5P@206389|Rhodocyclales	206389|Rhodocyclales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_160785_1	864051.BurJ1DRAFT_2900	8.36e-110	330.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KJUJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_417359_2	935557.ATYB01000008_gene5331	8.19e-68	216.0	COG0604@1|root,COG0604@2|Bacteria,1MXRX@1224|Proteobacteria,2TRSQ@28211|Alphaproteobacteria,4BDF6@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_717496_1	123899.JPQP01000009_gene308	3.53e-14	73.6	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,3T4BA@506|Alcaligenaceae	28216|Betaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	PEGA,Pkinase
k59_945777_1	395493.BegalDRAFT_0189	7.32e-88	278.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,461TW@72273|Thiotrichales	72273|Thiotrichales	M	Phosphoglycerol transferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_62726_1	391625.PPSIR1_12038	2.68e-62	205.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,42MXC@68525|delta/epsilon subdivisions,2WJJF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_96917_1	1100720.ALKN01000030_gene1069	4.78e-07	52.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,4ADJ3@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM VacJ family lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_96917_2	365046.Rta_02380	1.21e-44	155.0	2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2VKQ6@28216|Betaproteobacteria,4ABA6@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_254647_1	189753.AXAS01000056_gene5959	2.15e-29	112.0	COG2984@1|root,COG2984@2|Bacteria,1RDUT@1224|Proteobacteria,2U8XC@28211|Alphaproteobacteria,3JYZA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_717505_1	543728.Vapar_2030	1.05e-42	147.0	COG1546@1|root,COG1546@2|Bacteria,1RHXH@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the CinA family	MA20_19320	-	-	-	-	-	-	-	-	-	-	-	CinA
k59_96921_1	1000565.METUNv1_03890	1.09e-32	125.0	COG2304@1|root,COG2304@2|Bacteria,1MX8R@1224|Proteobacteria,2VT5A@28216|Betaproteobacteria	28216|Betaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K16259	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001	-	-	-	VWA_2
k59_96921_2	1097668.BYI23_B014500	4.4e-19	80.1	COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,2VRX8@28216|Betaproteobacteria,1K7DG@119060|Burkholderiaceae	28216|Betaproteobacteria	H	dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_750125_1	1485544.JQKP01000017_gene627	1.48e-14	70.9	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,44W0U@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Stringent starvation protein B	sspB	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
k59_1043228_2	666681.M301_1110	2.48e-120	346.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria,2KMDH@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
k59_813845_1	330214.NIDE0602	1.66e-140	412.0	COG1007@1|root,COG1007@2|Bacteria,3J0FN@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_813845_2	1121918.ARWE01000001_gene291	1.86e-06	52.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,43TUC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Proton-conducting membrane transporter	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_813870_1	1439940.BAY1663_02867	9.8e-20	82.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_813870_2	1123504.JQKD01000007_gene3336	1.16e-08	55.8	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VHZV@28216|Betaproteobacteria,4ADHI@80864|Comamonadaceae	28216|Betaproteobacteria	C	FMN-dependent dehydrogenase	mdlB	-	1.1.99.31	ko:K15054	ko00627,ko01120,map00627,map01120	-	R04160,R07664	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_1043327_1	292415.Tbd_1500	4.29e-86	273.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KSG5@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Inorganic H+ pyrophosphatase	-	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1043329_1	469383.Cwoe_4459	1.24e-13	77.4	COG0673@1|root,COG0673@2|Bacteria,2IEY3@201174|Actinobacteria,4CTIF@84995|Rubrobacteria	84995|Rubrobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_813991_1	945713.IALB_1459	2.1e-56	184.0	COG0142@1|root,COG0142@2|Bacteria	2|Bacteria	H	isoprenoid biosynthetic process	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	iYL1228.KPN_03597,ic_1306.c3945	polyprenyl_synt
k59_813991_2	860228.Ccan_06930	6.08e-13	68.2	COG0805@1|root,COG0805@2|Bacteria,4NEKM@976|Bacteroidetes,1HYNB@117743|Flavobacteriia,1EQZX@1016|Capnocytophaga	976|Bacteroidetes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_1043433_1	247633.GP2143_09320	5.07e-66	215.0	COG0624@1|root,COG0624@2|Bacteria,1R40H@1224|Proteobacteria,1SMXB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Peptidase family M20/M25/M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1043434_1	631454.N177_3173	6.76e-78	241.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria,1JNUP@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
k59_814149_1	1265505.ATUG01000001_gene3472	3.3e-32	127.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1043460_1	998674.ATTE01000001_gene3224	3.37e-09	57.4	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1RS4F@1236|Gammaproteobacteria,460Y3@72273|Thiotrichales	72273|Thiotrichales	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_1043460_2	1089545.KB913037_gene7151	4.68e-24	103.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4E0V5@85010|Pseudonocardiales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_1043480_1	1120925.F941_02790	5.37e-66	214.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,3NKNN@468|Moraxellaceae	1236|Gammaproteobacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_814192_1	338963.Pcar_1129	5.34e-61	193.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,42S4R@68525|delta/epsilon subdivisions,2WNE1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
k59_1043495_1	335659.S23_47630	1.65e-62	208.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria,3JX1U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_814210_1	1411685.U062_01186	1.08e-05	46.6	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1T1RB@1236|Gammaproteobacteria,1J8JX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_814210_2	1385513.N780_16145	2.41e-24	100.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,2Y8S8@289201|Pontibacillus	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1043517_1	335543.Sfum_0204	1.96e-22	90.1	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42SZV@68525|delta/epsilon subdivisions,2WP8T@28221|Deltaproteobacteria,2MQJF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4,Fer4_7
k59_1043517_2	335543.Sfum_0203	3.74e-63	201.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2MQ5S@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_814249_1	1000565.METUNv1_04055	1.47e-06	50.1	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,2KVUW@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
k59_1043529_1	1463857.JOFZ01000007_gene199	7.59e-08	59.7	COG0654@1|root,COG0654@2|Bacteria,2GJG5@201174|Actinobacteria	201174|Actinobacteria	CH	monooxygenase, FAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_1043536_1	273057.SSO2522	4.38e-17	84.3	COG1735@1|root,arCOG07263@2157|Archaea,2XRUD@28889|Crenarchaeota	28889|Crenarchaeota	S	Phosphotriesterase family	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
k59_1043576_1	1283300.ATXB01000001_gene157	2.29e-32	122.0	COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,1XG64@135618|Methylococcales	135618|Methylococcales	HJ	Sugar-transfer associated ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST
k59_1043576_2	314278.NB231_14803	3.14e-12	66.2	COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1X0CC@135613|Chromatiales	135613|Chromatiales	E	7 transmembrane helices usually fused to an inactive transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	7TM_transglut,Transglut_i_TM
k59_814320_1	879212.DespoDRAFT_00886	1.01e-95	288.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,42PGW@68525|delta/epsilon subdivisions,2WMMZ@28221|Deltaproteobacteria,2MKZD@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1043597_1	1397284.AYMN01000084_gene2427	9.35e-11	66.2	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,rve
k59_1043627_2	794903.OPIT5_05700	4.32e-41	143.0	COG1136@1|root,COG1136@2|Bacteria,46SKR@74201|Verrucomicrobia,3K7HB@414999|Opitutae	414999|Opitutae	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_814393_1	1121875.KB907547_gene2915	7.84e-56	189.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	CBS,Guanylate_cyc,Ion_trans,Ion_trans_2,Lipase_GDSL_2,NTP_transferase,cNMP_binding
k59_814426_1	945713.IALB_3091	1.9e-23	100.0	COG1200@1|root,COG1200@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1043664_1	1033743.CAES01000049_gene553	6.95e-42	153.0	COG1653@1|root,COG1653@2|Bacteria,1TPX9@1239|Firmicutes,4HI13@91061|Bacilli,276C3@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
k59_814443_1	323848.Nmul_A1803	5.47e-113	338.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,372GA@32003|Nitrosomonadales	28216|Betaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_814454_1	614083.AWQR01000055_gene1971	3.01e-74	236.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2W3RM@28216|Betaproteobacteria,4AJVP@80864|Comamonadaceae	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_814505_1	864069.MicloDRAFT_00005900	7.9e-07	56.6	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria,1JQUY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_814509_1	1121405.dsmv_0075	1.64e-46	169.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria,2MJZI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1043762_1	1219045.BV98_001048	8.3e-34	137.0	COG0739@1|root,COG2304@1|root,COG2755@1|root,COG2911@1|root,COG0739@2|Bacteria,COG2304@2|Bacteria,COG2755@2|Bacteria,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,2TWAF@28211|Alphaproteobacteria,2KEDJ@204457|Sphingomonadales	204457|Sphingomonadales	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1043819_1	1082933.MEA186_30901	7.97e-57	209.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_814691_1	1205680.CAKO01000015_gene137	7.31e-36	132.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,2JQ0D@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_814691_2	1002672.SAR11G3_01300	9.53e-50	169.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2UBG9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_1043911_1	1041146.ATZB01000082_gene5372	2.65e-20	95.9	COG2931@1|root,COG2931@2|Bacteria,1R4Z6@1224|Proteobacteria,2U455@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1043926_1	1547437.LL06_25595	0.000251	50.4	COG2304@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4733@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2UGU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4082,DUF4347,HemolysinCabind
k59_1043947_1	1283284.AZUK01000002_gene2769	4.17e-33	134.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,1Y5S8@135624|Aeromonadales	135624|Aeromonadales	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1044000_1	1248917.ANFX01000012_gene1784	4.01e-28	117.0	COG3210@1|root,COG3595@1|root,COG3210@2|Bacteria,COG3595@2|Bacteria,1R8TG@1224|Proteobacteria,2U41V@28211|Alphaproteobacteria,2K1DN@204457|Sphingomonadales	204457|Sphingomonadales	U	COG3210 Large exoproteins involved in heme utilization or adhesion	-	-	-	-	-	-	-	-	-	-	-	-	Haemagg_act
k59_814812_1	414684.RC1_1820	9.13e-96	298.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TUXY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EU	peptidase S9	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_814820_1	582899.Hden_0696	4.37e-80	240.0	COG0509@1|root,COG0509@2|Bacteria,1RKRS@1224|Proteobacteria,2UAPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glycine cleavage H-protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_814820_2	190650.CC_2864	3.77e-27	103.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,2KIXV@204458|Caulobacterales	204458|Caulobacterales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_814857_1	323848.Nmul_A1426	8.93e-57	196.0	COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VKC9@28216|Betaproteobacteria,372G4@32003|Nitrosomonadales	28216|Betaproteobacteria	P	TonB-dependent Receptor Plug Domain	yncD	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_814964_1	522306.CAP2UW1_2799	3.26e-80	262.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.9	ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_815057_1	1215092.PA6_006_02120	1.75e-81	254.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,1YI6S@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	NMT1-like family	nasF	-	-	ko:K15576,ko:K22067	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000,ko02022	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2,TAT_signal
k59_815122_1	883156.HMPREF9282_00941	5.23e-19	92.8	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H2W4@909932|Negativicutes	909932|Negativicutes	L	SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_815218_1	85643.Tmz1t_2648	1.63e-78	257.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_815243_1	945713.IALB_2896	1.19e-83	259.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_392967_2	388051.AUFE01000051_gene3007	9.12e-05	43.9	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria,2VZQY@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k59_229722_1	1121033.AUCF01000008_gene5655	3.88e-16	75.9	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,2JRTK@204441|Rhodospirillales	204441|Rhodospirillales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_229722_2	1333998.M2A_1798	1.68e-20	90.5	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,4BPEF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_99259_1	580332.Slit_2252	8.25e-58	186.0	COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,2VSD5@28216|Betaproteobacteria,44VVM@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA	hscB	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,HSCB_C
k59_33973_1	1027292.HMPREF9372_1061	5.44e-61	202.0	COG0069@1|root,COG0069@2|Bacteria,1TSHA@1239|Firmicutes,4HA97@91061|Bacilli,26CUZ@186818|Planococcaceae	91061|Bacilli	E	Belongs to the glutamate synthase family	yerD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	Glu_synthase
k59_262550_2	305700.B447_19454	4.81e-69	216.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,2KUT2@206389|Rhodocyclales	206389|Rhodocyclales	K	RNA polymerase sigma	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_751991_1	1304275.C41B8_15942	1.51e-43	156.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	ATPase related to phosphate starvation-inducible protein PhoH	phoH	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_360299_1	1288494.EBAPG3_22410	6.55e-65	201.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2VSRT@28216|Betaproteobacteria,37338@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_66658_1	1121028.ARQE01000016_gene2619	2.02e-30	114.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2PK0U@255475|Aurantimonadaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_66658_2	244582.JQAK01000012_gene2377	2.83e-36	125.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,47FV9@766|Rickettsiales	766|Rickettsiales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_556456_1	925409.KI911562_gene44	6.21e-45	166.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,4NFUJ@976|Bacteroidetes,1IP28@117747|Sphingobacteriia	976|Bacteroidetes	C	malic enzyme	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_850066_1	886293.Sinac_1109	7.12e-22	94.7	COG0461@1|root,COG0461@2|Bacteria,2IZA7@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_850066_3	330214.NIDE0220	2.12e-17	77.8	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_491160_2	991.IW20_07470	2.59e-10	63.2	COG3325@1|root,COG3469@1|root,COG3325@2|Bacteria,COG3469@2|Bacteria,4PKBR@976|Bacteroidetes,1IIGZ@117743|Flavobacteriia,2NU8S@237|Flavobacterium	976|Bacteroidetes	G	Glyco_18	-	GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005575,GO:0005576,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006040,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016798,GO:0017144,GO:0042737,GO:0043170,GO:0044237,GO:0044248,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12,CarboxypepD_reg,Glyco_hydro_18
k59_360306_1	1117647.M5M_11105	1.84e-126	378.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_197258_1	637390.AFOH01000046_gene2106	1.24e-61	203.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1SYTB@1236|Gammaproteobacteria,2NC77@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_262567_1	1177928.TH2_04623	2.39e-09	61.6	COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria,2TRVV@28211|Alphaproteobacteria,2JRW4@204441|Rhodospirillales	204441|Rhodospirillales	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_589045_1	1157490.EL26_19025	1.21e-22	95.5	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4HH2N@91061|Bacilli,278HX@186823|Alicyclobacillaceae	91061|Bacilli	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_589045_2	1265505.ATUG01000003_gene89	9.08e-10	58.5	COG1925@1|root,COG1925@2|Bacteria,1PW7I@1224|Proteobacteria,42N77@68525|delta/epsilon subdivisions,2WKSU@28221|Deltaproteobacteria,2MI26@213118|Desulfobacterales	28221|Deltaproteobacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_556477_1	1125863.JAFN01000001_gene666	2.43e-15	73.9	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,42SHG@68525|delta/epsilon subdivisions,2WP1D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
k59_556477_2	1121035.AUCH01000004_gene343	8.06e-19	90.9	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,2KUWP@206389|Rhodocyclales	206389|Rhodocyclales	O	peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_3
k59_433025_1	85643.Tmz1t_0889	1.47e-86	262.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,2KUIX@206389|Rhodocyclales	206389|Rhodocyclales	Q	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_433025_2	1298593.TOL_3094	3.64e-08	54.3	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1XI6F@135619|Oceanospirillales	135619|Oceanospirillales	Q	ABC transporter maintaining outer membrane lipid asymmetry	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_662312_1	1234364.AMSF01000015_gene3132	7.13e-36	131.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1X32A@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	fadA	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
k59_662312_2	1266925.JHVX01000008_gene322	2.58e-55	192.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,3725I@32003|Nitrosomonadales	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadN	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_758191_1	945713.IALB_1473	4.24e-61	196.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	liuC	-	4.2.1.17,4.2.1.18,4.2.1.57	ko:K01692,ko:K13766,ko:K13779	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00036,M00087	R02085,R03026,R03045,R03493,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC00941,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_727483_1	998088.B565_2659	1.59e-111	338.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1Y3K5@135624|Aeromonadales	135624|Aeromonadales	G	Phosphoglucomutase	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_107068_1	1121405.dsmv_0994	4.26e-67	215.0	COG0589@1|root,COG0589@2|Bacteria,1RF1N@1224|Proteobacteria,42S7A@68525|delta/epsilon subdivisions,2WNZK@28221|Deltaproteobacteria,2MKM5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_9287_1	1121918.ARWE01000001_gene74	4.7e-143	416.0	COG4881@1|root,COG4881@2|Bacteria,1QXMX@1224|Proteobacteria,43C41@68525|delta/epsilon subdivisions,2WKYD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Polysulphide reductase, NrfD	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_9287_2	269799.Gmet_3519	1.82e-31	116.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42QZ2@68525|delta/epsilon subdivisions,2WMS4@28221|Deltaproteobacteria,43T2N@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	cbcT	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_2,Fer4_3,Fer4_7
k59_988001_1	330084.JNYZ01000013_gene5766	3.82e-34	124.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria,4DY5Q@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_399249_1	391735.Veis_1099	3.28e-18	83.2	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2VNGN@28216|Betaproteobacteria,4AJ8R@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_399249_2	159450.NH14_08355	6e-34	130.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2VMMA@28216|Betaproteobacteria,1K51F@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.3.19,1.5.8.4	ko:K00315,ko:K19191	ko00260,ko00760,ko01100,ko01120,map00260,map00760,map01100,map01120	-	R01565,R10102	RC00060,RC00181,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_695038_1	1434929.X946_3446	1.54e-38	144.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria,1K0GR@119060|Burkholderiaceae	28216|Betaproteobacteria	M	transglycosylase	slt	-	3.2.1.17	ko:K01185	-	-	-	-	ko00000,ko01000	-	-	-	SLT
k59_9297_1	1280948.HY36_17905	1.43e-28	107.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_988014_1	391735.Veis_1395	5.81e-26	107.0	COG1820@1|root,COG1820@2|Bacteria,1MW8Y@1224|Proteobacteria,2VK6M@28216|Betaproteobacteria,4AFKZ@80864|Comamonadaceae	28216|Betaproteobacteria	G	Amidohydrolase family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_107079_2	1131553.JIBI01000004_gene391	3.68e-90	270.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2VMPA@28216|Betaproteobacteria,37223@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	PFAM Methionine biosynthesis MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
k59_107079_3	392499.Swit_1209	5.98e-16	76.6	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,2TTD2@28211|Alphaproteobacteria,2K1E8@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_399261_1	314285.KT71_13519	1.6e-98	315.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1J4SF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_727507_1	880072.Desac_1527	2.65e-10	59.7	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MQ80@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_727507_2	880072.Desac_1528	7.3e-67	215.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,2MR20@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
k59_629266_1	3218.PP1S240_11V6.1	6.85e-23	104.0	COG0642@1|root,KOG0519@2759|Eukaryota,37YPU@33090|Viridiplantae,3GNVQ@35493|Streptophyta	35493|Streptophyta	T	His Kinase A (phospho-acceptor) domain	-	-	2.7.13.3	ko:K19691	ko02020,map02020	M00516	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,MASE1,Response_reg
k59_786439_1	945713.IALB_0586	7.27e-71	239.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2
k59_662348_1	762376.AXYL_01490	3.21e-63	208.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2W925@28216|Betaproteobacteria,3T6IU@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_662348_2	1123504.JQKD01000029_gene4188	3.83e-06	49.3	COG3181@1|root,COG3181@2|Bacteria,1R5RT@1224|Proteobacteria,2VJT4@28216|Betaproteobacteria,4AASU@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_107092_1	1005395.CSV86_19592	2.2e-08	57.8	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,1RQ5K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC transporter substrate-binding protein	-	-	5.3.3.7	ko:K02020,ko:K22003	ko00660,ko02010,map00660,map02010	M00189	R02244	RC00668	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_107092_2	1469245.JFBG01000038_gene1840	9.06e-08	53.9	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_499125_1	1057002.KB905370_gene4647	1.46e-06	50.1	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2TRA7@28211|Alphaproteobacteria,4B9NN@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Glycolate oxidase subunit	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_499125_2	1267005.KB911255_gene2629	1.04e-46	163.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,3N890@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cysteine-rich domain	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
k59_270250_1	880072.Desac_0544	1.11e-126	394.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	por	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_107101_1	316067.Geob_3601	1.45e-26	100.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,43UKC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_107101_2	631454.N177_0753	2.1e-51	166.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,1JNYC@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_107101_3	1121267.JHZL01000006_gene949	1.65e-15	68.9	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2YQQ9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
k59_107101_4	1033730.CAHG01000004_gene3	1.69e-15	73.9	COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,4DP2T@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_302276_1	1123371.ATXH01000001_gene1278	2.27e-21	91.7	COG0071@1|root,COG0071@2|Bacteria,2GHTW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_955977_1	588932.JHOF01000027_gene1534	0.000224	45.1	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2KFWJ@204458|Caulobacterales	204458|Caulobacterales	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_9333_1	56780.SYN_03249	4.48e-71	226.0	COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,42TEG@68525|delta/epsilon subdivisions,2WPXW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_923545_1	204773.HEAR0350	1.05e-65	214.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,476QA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_923545_2	543728.Vapar_4492	1.02e-21	91.3	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2VRUQ@28216|Betaproteobacteria,4AERJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_564330_1	330214.NIDE3308	6.14e-94	280.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,fn3_3
k59_172359_1	382464.ABSI01000010_gene3328	5.06e-34	137.0	COG1611@1|root,COG1611@2|Bacteria,46UPU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_464419_1	1385515.N791_10540	1.68e-110	324.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1X3QU@135614|Xanthomonadales	135614|Xanthomonadales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_74683_1	1304874.JAFY01000005_gene1600	3e-50	177.0	COG3845@1|root,COG3845@2|Bacteria,3TAF4@508458|Synergistetes	508458|Synergistetes	S	PFAM ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_9346_1	748247.AZKH_0927	6.41e-62	213.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,2KVBE@206389|Rhodocyclales	206389|Rhodocyclales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_889794_1	279714.FuraDRAFT_0382	1.27e-41	160.0	COG2199@1|root,COG2200@1|root,COG2202@1|root,COG5002@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WHDZ@28216|Betaproteobacteria,2KTWU@206351|Neisseriales	206351|Neisseriales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4
k59_891001_1	176946.XP_007429693.1	1.37e-09	58.5	COG0461@1|root,KOG1377@2759|Eukaryota,38EAF@33154|Opisthokonta,3B9I3@33208|Metazoa,3CTV1@33213|Bilateria,48B70@7711|Chordata,48XQV@7742|Vertebrata	33208|Metazoa	F	orotate phosphoribosyltransferase activity	UMPS	GO:0003674,GO:0003824,GO:0004588,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046112,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.10,4.1.1.23	ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
k59_891001_2	90813.JQMT01000001_gene1005	3.31e-26	104.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,4603F@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_924808_1	1229909.NSED_01245	9.55e-224	621.0	arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_237078_1	1128912.GMES_4094	2.08e-08	54.7	COG2271@1|root,COG2271@2|Bacteria,1MX4V@1224|Proteobacteria,1RMB3@1236|Gammaproteobacteria,46A15@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Major Facilitator Superfamily	glpT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0008643,GO:0015075,GO:0015103,GO:0015114,GO:0015144,GO:0015166,GO:0015168,GO:0015291,GO:0015297,GO:0015301,GO:0015315,GO:0015318,GO:0015527,GO:0015698,GO:0015711,GO:0015748,GO:0015791,GO:0015793,GO:0015794,GO:0015850,GO:0016020,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:0099516,GO:1901264,GO:1901618	-	ko:K02445	-	-	-	-	ko00000,ko02000	2.A.1.4.3	-	iECH74115_1262.ECH74115_3377,iECIAI39_1322.ECIAI39_2383,iECSP_1301.ECSP_3115,iECs_1301.ECs3125,iEcSMS35_1347.EcSMS35_2392,iG2583_1286.G2583_2780,iSFV_1184.SFV_2312,iZ_1308.Z3498	MFS_1
k59_237078_2	1121434.AULY01000006_gene529	6.36e-98	298.0	COG2271@1|root,COG2271@2|Bacteria,1MX4V@1224|Proteobacteria,42QEQ@68525|delta/epsilon subdivisions,2WQEB@28221|Deltaproteobacteria,2MBT1@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K02445,ko:K07783	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.1.4.3,2.A.1.4.4,2.A.1.4.6	-	-	MFS_1
k59_434298_1	748247.AZKH_0338	1.81e-71	222.0	COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,2VI4N@28216|Betaproteobacteria,2KZCZ@206389|Rhodocyclales	206389|Rhodocyclales	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_786888_2	2340.JV46_14790	1.6e-107	318.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1J5D9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360	ACP_syn_III,ACP_syn_III_C
k59_369094_1	1454004.AW11_01714	2.26e-39	143.0	COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,1KQSE@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_8
k59_1016906_1	1112217.PPL19_06480	9.41e-09	62.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	membrane-associated protein	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
k59_924819_1	1382304.JNIL01000001_gene827	3.08e-79	249.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,278SD@186823|Alicyclobacillaceae	91061|Bacilli	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_957333_1	1120958.AULD01000005_gene2090	2.26e-05	47.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4FM83@85023|Microbacteriaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0030312,GO:0044464,GO:0071944	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_237088_1	243233.MCA0165	5.55e-131	388.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1XEHB@135618|Methylococcales	135618|Methylococcales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_271492_2	1304883.KI912532_gene1580	1.33e-07	54.3	COG4701@1|root,COG4701@2|Bacteria,1NHRC@1224|Proteobacteria,2WB0Y@28216|Betaproteobacteria,2KX66@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
k59_630542_1	696369.KI912183_gene2731	2.11e-11	59.7	2CEAQ@1|root,33N8U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_696400_1	330214.NIDE3384	1.11e-164	501.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,3J0SV@40117|Nitrospirae	40117|Nitrospirae	C	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_728864_2	279010.BL03961	3.31e-10	57.0	COG1942@1|root,COG1942@2|Bacteria,1VKD5@1239|Firmicutes,4HRBS@91061|Bacilli,1ZITA@1386|Bacillus	91061|Bacilli	G	4-oxalocrotonate tautomerase	dmpI	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0044237	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_728864_3	1379701.JPJC01000212_gene1955	5.95e-07	52.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,2K05I@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_76016_1	1160718.SU9_10658	1.04e-30	128.0	COG3391@1|root,COG3391@2|Bacteria,2H4SV@201174|Actinobacteria	201174|Actinobacteria	MU	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
k59_237092_1	439235.Dalk_3678	7.13e-87	267.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2WJPP@28221|Deltaproteobacteria,2MIY7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_237092_2	439235.Dalk_3678	5.21e-06	47.4	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2WJPP@28221|Deltaproteobacteria,2MIY7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_759341_1	1267535.KB906767_gene3177	1.58e-233	657.0	COG1158@1|root,COG1158@2|Bacteria,3Y2V3@57723|Acidobacteria,2JHRC@204432|Acidobacteriia	204432|Acidobacteriia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_173685_1	1459636.NTE_03553	1.12e-91	280.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_336781_1	1131553.JIBI01000023_gene342	5.85e-11	62.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,371W8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
k59_336781_2	323848.Nmul_A2187	1.59e-40	146.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,37277@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_369117_1	1293054.HSACCH_01641	2.62e-69	225.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,24ZIP@186801|Clostridia	186801|Clostridia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_924834_1	519989.ECTPHS_07242	5.33e-176	505.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_924834_2	1042377.AFPJ01000023_gene651	7.36e-20	92.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,46433@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_206043_1	748247.AZKH_0007	4.73e-85	259.0	2C7Q9@1|root,2Z96K@2|Bacteria,1MWKA@1224|Proteobacteria,2VN2M@28216|Betaproteobacteria,2KUGB@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_728880_1	1415779.JOMH01000001_gene2889	3.62e-07	55.1	COG0664@1|root,COG0664@2|Bacteria,1RE4X@1224|Proteobacteria,1S6Z7@1236|Gammaproteobacteria,1X91Q@135614|Xanthomonadales	135614|Xanthomonadales	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_529257_2	977880.RALTA_A1854	4.98e-35	128.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,1K1RS@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_565665_1	1232683.ADIMK_0867	3.1e-78	259.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_303487_1	497964.CfE428DRAFT_0593	1.01e-47	166.0	COG3666@1|root,COG3666@2|Bacteria,46S8M@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_206053_2	1380380.JIAX01000015_gene2924	5.65e-05	46.2	COG0398@1|root,COG0398@2|Bacteria,1RDZ2@1224|Proteobacteria,2U8CD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	ydjZ	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_271510_2	525897.Dbac_1087	7.06e-53	169.0	2E8QN@1|root,3331M@2|Bacteria,1ND4I@1224|Proteobacteria,430TR@68525|delta/epsilon subdivisions,2WVZ7@28221|Deltaproteobacteria,2MF52@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_737221_1	1485544.JQKP01000002_gene1562	9.99e-53	182.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,44VJY@713636|Nitrosomonadales	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_737221_2	292.DM42_2208	6.1e-38	129.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,1K8I2@119060|Burkholderiaceae	28216|Betaproteobacteria	G	phosphocarrier, HPr family	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_737221_3	338969.Rfer_0601	3.13e-10	59.3	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,4AEDR@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM PTS system fructose subfamily IIA component	manX	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	EIIA-man
k59_84199_1	1266925.JHVX01000006_gene2245	4.94e-66	217.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,372EM@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_50935_1	338969.Rfer_3852	2.4e-92	284.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,4AFB1@80864|Comamonadaceae	28216|Betaproteobacteria	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_243785_1	713586.KB900536_gene2247	2.49e-66	211.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_997227_1	373903.Hore_08350	1.8e-94	284.0	COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_789900_1	379731.PST_4076	3.98e-67	216.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,1SYCA@1236|Gammaproteobacteria,1YZNW@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_181654_1	1424334.W822_02710	1.1e-113	334.0	COG2175@1|root,COG2175@2|Bacteria,1NTZW@1224|Proteobacteria,2W0BS@28216|Betaproteobacteria,3T7GT@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	ko:K06912	ko00361,ko01120,ko01220,map00361,map01120,map01220	-	R05419,R05493	RC01371,RC01372	ko00000,ko00001,ko01000	-	-	-	TauD
k59_116501_1	323848.Nmul_A0434	2.79e-81	256.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,371PP@32003|Nitrosomonadales	28216|Betaproteobacteria	FP	Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_965683_1	204773.HEAR0393	1.02e-113	334.0	COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,2VKMF@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Formate nitrite	-	-	-	ko:K02598,ko:K06212	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.3	-	-	Form_Nir_trans
k59_243791_1	1210884.HG799470_gene14461	8.52e-16	80.5	COG1277@1|root,COG1277@2|Bacteria,2J09F@203682|Planctomycetes	203682|Planctomycetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_243791_2	1121957.ATVL01000007_gene2344	1.39e-07	55.1	COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,47KF6@768503|Cytophagia	976|Bacteroidetes	V	TIGRFAM Gliding motility-associated ABC transporter ATP-binding subunit GldA	gldA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_573866_1	312153.Pnuc_0136	1.67e-19	88.2	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,1K2D1@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_573866_2	1236959.BAMT01000002_gene1902	9.35e-19	85.9	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria,2KKTU@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_638423_1	1118235.CAJH01000038_gene2309	8.29e-74	232.0	COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1X38D@135614|Xanthomonadales	135614|Xanthomonadales	M	synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_149198_1	859657.RPSI07_3334	1.99e-146	431.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,1K2J1@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ABC transporter substrate-binding protein	dppA	-	-	ko:K02035,ko:K13889	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	SBP_bac_5
k59_149198_2	1123367.C666_11740	1.78e-79	255.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,2KWWE@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_997237_1	1437824.BN940_15161	9.76e-123	384.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,3T1IE@506|Alcaligenaceae	28216|Betaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_84214_1	330214.NIDE1643	1.18e-175	506.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_149203_1	864702.OsccyDRAFT_2457	5.74e-70	220.0	COG0031@1|root,COG0031@2|Bacteria,1G1AB@1117|Cyanobacteria,1H7G5@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_116521_1	1188795.K7ZJS4_9CAUD	7.25e-14	78.6	4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses  no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae	10744|Podoviridae	S	Bacteriophage head to tail connecting protein	-	GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704	-	-	-	-	-	-	-	-	-	-	-
k59_965698_1	1449049.JONW01000005_gene1399	3.11e-25	108.0	28JIP@1|root,2ZCBM@2|Bacteria	2|Bacteria	S	S1/P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
k59_835365_1	1183438.GKIL_0704	3.17e-53	188.0	COG0449@1|root,COG0449@2|Bacteria,1FZVQ@1117|Cyanobacteria	1117|Cyanobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_671986_1	1276756.AUEX01000040_gene335	2.16e-112	335.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,4AAHZ@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
k59_442119_1	1205680.CAKO01000002_gene3005	6.61e-27	107.0	COG4177@1|root,COG4177@2|Bacteria,1NE3E@1224|Proteobacteria,2TTWY@28211|Alphaproteobacteria,2JT5A@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_442119_2	768710.DesyoDRAFT_3853	5.75e-17	80.9	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,260BU@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_835370_1	330214.NIDE0725	3.66e-40	136.0	COG3255@1|root,COG3255@2|Bacteria	2|Bacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
k59_835370_2	330214.NIDE0726	0.000937	42.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_573899_1	203119.Cthe_1751	1.52e-30	122.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,3WGD4@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_965716_1	436308.Nmar_1187	1.56e-12	63.5	arCOG08690@1|root,arCOG08690@2157|Archaea,41T98@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_214944_1	1288494.EBAPG3_3040	2.61e-128	379.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,371N8@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_934112_1	330214.NIDE1418	7.08e-90	274.0	COG1386@1|root,COG1386@2|Bacteria,3J15Z@40117|Nitrospirae	40117|Nitrospirae	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_966720_1	1125973.JNLC01000001_gene189	3.23e-25	108.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,3JVKY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	TrkA-C domain	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_966720_2	1121413.JMKT01000009_gene2096	6.26e-11	62.4	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2M9JU@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_377788_1	953739.SVEN_6978	2.31e-10	65.5	COG0604@1|root,COG0604@2|Bacteria,2GK7Y@201174|Actinobacteria	201174|Actinobacteria	C	NADPH quinone	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_934121_1	589924.Ferp_1257	9.16e-52	183.0	COG0243@1|root,COG1153@1|root,arCOG01495@2157|Archaea,arCOG02674@2157|Archaea,2Y8AD@28890|Euryarchaeota	28890|Euryarchaeota	C	Molybdopterin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_473048_2	1131266.ARWQ01000002_gene551	3.41e-22	94.4	COG3425@1|root,arCOG01767@2157|Archaea,41SAQ@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Hydroxymethylglutaryl-coenzyme A synthase N terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG_CoA_synt_C,HMG_CoA_synt_N
k59_377793_1	359.CN09_26010	1.69e-70	224.0	COG0657@1|root,COG0657@2|Bacteria,1R41U@1224|Proteobacteria,2U17T@28211|Alphaproteobacteria,4BIBG@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
k59_345768_1	395493.BegalDRAFT_3559	3.54e-92	292.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,45ZUZ@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_19859_1	580332.Slit_1269	0.000148	43.9	COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,PEGA
k59_19859_2	614083.AWQR01000055_gene1979	1.12e-139	402.0	COG2972@1|root,COG2972@2|Bacteria,1QYRK@1224|Proteobacteria,2WHJ2@28216|Betaproteobacteria,4AGMA@80864|Comamonadaceae	28216|Betaproteobacteria	T	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP
k59_150229_1	1120968.AUBX01000010_gene1279	5.19e-32	125.0	COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,47JZD@768503|Cytophagia	976|Bacteroidetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_607102_1	1163617.SCD_n00349	1.58e-91	289.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2VM8J@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
k59_214967_1	330214.NIDE0770	3.68e-59	192.0	COG0345@1|root,COG0345@2|Bacteria,3J0N8@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_790331_1	926569.ANT_08160	1.5e-54	185.0	COG0842@1|root,COG0842@2|Bacteria,2G774@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_19865_1	760568.Desku_1432	3.28e-45	157.0	COG4656@1|root,COG4656@2|Bacteria,1UIC8@1239|Firmicutes,25EHB@186801|Clostridia,267BW@186807|Peptococcaceae	186801|Clostridia	C	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_17,Fer4_8,FrhB_FdhB_C
k59_117565_1	1168289.AJKI01000044_gene93	1.89e-90	271.0	COG0297@1|root,COG0297@2|Bacteria,4NFP8@976|Bacteroidetes,2FN7D@200643|Bacteroidia,3XJD4@558415|Marinilabiliaceae	976|Bacteroidetes	G	Starch synthase catalytic domain	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5
k59_51913_1	745411.B3C1_06859	4.76e-124	370.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1J5UX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG3104 Dipeptide tripeptide permease	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_509645_1	235985.BBPN01000003_gene4562	0.000129	43.1	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_509645_2	330214.NIDE0974	1.66e-57	182.0	COG4911@1|root,COG4911@2|Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
k59_117580_1	1265502.KB905931_gene1753	3.15e-64	215.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,4ABCV@80864|Comamonadaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_51924_1	999541.bgla_1g31640	4.59e-69	220.0	COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2VNHF@28216|Betaproteobacteria,1K2DN@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the precorrin methyltransferase family	cysG	-	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
k59_934168_1	330214.NIDE3974	8.76e-69	222.0	COG1012@1|root,COG1012@2|Bacteria,3J0YN@40117|Nitrospirae	40117|Nitrospirae	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_51928_1	987059.RBXJA2T_03993	1.54e-130	388.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,1KIWS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_244723_1	1217710.F969_00357	3.4e-37	142.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,3NJ42@468|Moraxellaceae	1236|Gammaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_4025	PEPcase
k59_345807_1	1249627.D779_2217	1.2e-09	58.2	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales	135613|Chromatiales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_345807_2	883126.HMPREF9710_00002	8.33e-137	398.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,473H7@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_574935_1	1120983.KB894571_gene2091	2.8e-58	195.0	COG1593@1|root,COG1593@2|Bacteria,1N1HM@1224|Proteobacteria,2TR8B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_867850_1	1265313.HRUBRA_00044	3.76e-18	84.3	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1J4NK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_244728_1	316067.Geob_3345	1.52e-81	254.0	COG1333@1|root,COG1333@2|Bacteria	2|Bacteria	O	cytochrome c biogenesis protein	resB	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
k59_51937_1	637389.Acaty_c0045	1.05e-58	192.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1S470@1236|Gammaproteobacteria,2NDJX@225057|Acidithiobacillales	225057|Acidithiobacillales	M	RmlD substrate binding domain	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_607151_1	582515.KR51_00005210	3.55e-82	250.0	COG0396@1|root,COG0396@2|Bacteria,1G11H@1117|Cyanobacteria	1117|Cyanobacteria	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_836455_1	1366050.N234_36085	6.37e-220	612.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1K2WH@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_32
k59_19907_1	1121918.ARWE01000001_gene2066	6.89e-16	75.5	COG1414@1|root,COG1414@2|Bacteria,1PHH3@1224|Proteobacteria,42Z0C@68525|delta/epsilon subdivisions,2WTST@28221|Deltaproteobacteria,43TUW@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_673116_1	880070.Cycma_4163	1.16e-34	135.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes	976|Bacteroidetes	P	TonB-linked outer membrane protein, SusC RagA family	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_215017_1	1036674.A28LD_0609	2.63e-37	138.0	COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,1RR21@1236|Gammaproteobacteria,2QFH5@267893|Idiomarinaceae	1236|Gammaproteobacteria	I	Acyltransferase	yihG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_509675_1	929556.Solca_0753	3.6e-84	256.0	COG0500@1|root,COG2226@2|Bacteria,4NFRD@976|Bacteroidetes,1IVKT@117747|Sphingobacteriia	976|Bacteroidetes	Q	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_117603_1	292.DM42_1457	2.73e-25	97.1	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,1K7WM@119060|Burkholderiaceae	28216|Betaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_244741_1	622637.KE124774_gene3979	5.94e-91	273.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,36ZYD@31993|Methylocystaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_182734_1	404589.Anae109_1032	1.08e-57	207.0	COG4262@1|root,COG4262@2|Bacteria	2|Bacteria	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,Spermine_synth
k59_117616_2	1095769.CAHF01000022_gene339	8.72e-14	71.6	COG4966@1|root,COG4966@2|Bacteria,1RC4Q@1224|Proteobacteria,2VS7N@28216|Betaproteobacteria,476YR@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type IV Pilus-assembly protein W	pilW	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
k59_19921_1	1298858.AUEL01000004_gene1057	3.22e-74	236.0	COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,43MH7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
k59_215031_1	1120949.KB903299_gene6011	4.65e-47	160.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria	201174|Actinobacteria	I	3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_867876_1	1236541.BALL01000013_gene1982	3.85e-20	86.3	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,2Q8X8@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_867876_2	1283300.ATXB01000001_gene1274	1.75e-32	125.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_182736_1	391735.Veis_3679	3.19e-246	687.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2VK8B@28216|Betaproteobacteria,4ABJ1@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_117626_1	1123393.KB891332_gene2765	2e-67	220.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,1KSSH@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_317816_1	945713.IALB_0615	1.39e-74	237.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.12	ko:K00694,ko:K00786	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Glyco_tranf_2_3
k59_1004686_1	421531.IX38_01715	2.71e-28	112.0	COG0516@1|root,COG0516@2|Bacteria,4NHGE@976|Bacteroidetes,1HX35@117743|Flavobacteriia,3ZNPK@59732|Chryseobacterium	976|Bacteroidetes	F	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides	guaC	-	1.7.1.7	ko:K00364	ko00230,map00230	-	R01134	RC00457	ko00000,ko00001,ko01000	-	-	-	IMPDH
k59_1004686_2	1469245.JFBG01000027_gene1478	1.88e-11	65.9	COG0778@1|root,COG0778@2|Bacteria,1NIJ8@1224|Proteobacteria,1RMRT@1236|Gammaproteobacteria,1X1VN@135613|Chromatiales	135613|Chromatiales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_613744_1	592015.HMPREF1705_01092	9.69e-24	104.0	COG0744@1|root,COG0744@2|Bacteria,3TA4T@508458|Synergistetes	508458|Synergistetes	M	penicillin-binding protein, 1A family	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_874365_1	711393.AYRX01000024_gene1471	1.66e-23	102.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_745222_1	1163617.SCD_n01628	1.09e-71	231.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_478813_1	1278073.MYSTI_05613	7.32e-48	178.0	COG0421@1|root,COG0421@2|Bacteria,1QX98@1224|Proteobacteria,43C2D@68525|delta/epsilon subdivisions,2X7CZ@28221|Deltaproteobacteria,2Z3FM@29|Myxococcales	28221|Deltaproteobacteria	E	Spermine/spermidine synthase domain	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_516504_1	933262.AXAM01000009_gene1489	7.86e-66	217.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria,2MHWQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	reductase, alpha subunit	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_413906_1	1000565.METUNv1_03440	4.05e-51	169.0	COG1670@1|root,COG1670@2|Bacteria,1PZTX@1224|Proteobacteria,2W4BT@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_59193_1	1163617.SCD_n00821	5.68e-62	196.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2VHHT@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_59193_2	1288494.EBAPG3_4280	1.59e-06	49.3	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,3725D@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_450501_1	96561.Dole_1569	1.17e-55	189.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MI03@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1005628_1	671143.DAMO_1570	2.1e-54	177.0	COG0639@1|root,COG0639@2|Bacteria,2NQ2C@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase	prp1	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
k59_1005628_2	395019.Bmul_3193	2.33e-12	71.6	COG0642@1|root,COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,1JZSA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS,PAS_10,Response_reg
k59_353399_2	572477.Alvin_2789	3.24e-10	60.8	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_318734_1	1502850.FG91_00925	1.25e-35	136.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PR9I@1224|Proteobacteria,2U1SM@28211|Alphaproteobacteria,2K253@204457|Sphingomonadales	204457|Sphingomonadales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Pyr_redox_3
k59_59198_1	553217.ENHAE0001_2146	7.31e-52	174.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,3NKGX@468|Moraxellaceae	1236|Gammaproteobacteria	C	Belongs to the citrate synthase family	prpC	GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630	Citrate_synt
k59_59198_2	187272.Mlg_2601	2.88e-15	75.5	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria,1WWIP@135613|Chromatiales	135613|Chromatiales	S	2-methylcitrate dehydratase	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
k59_353401_2	196490.AUEZ01000085_gene1281	9.52e-35	131.0	COG0655@1|root,COG0655@2|Bacteria,1MX6A@1224|Proteobacteria,2TU75@28211|Alphaproteobacteria,3JTKI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_157825_1	554065.XP_005846937.1	1.04e-62	209.0	COG0446@1|root,KOG1336@2759|Eukaryota,37X56@33090|Viridiplantae,34JPC@3041|Chlorophyta	3041|Chlorophyta	S	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Rhodanese
k59_875355_1	1454004.AW11_01300	4.79e-78	243.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_582903_1	1269813.ATUL01000017_gene2543	5.75e-42	152.0	COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,1S8EQ@1236|Gammaproteobacteria,1WYKW@135613|Chromatiales	135613|Chromatiales	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_906931_1	1265502.KB905938_gene2476	8e-52	168.0	COG3937@1|root,COG3937@2|Bacteria,1RIXG@1224|Proteobacteria,2VT1J@28216|Betaproteobacteria,4ADWD@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM poly granule associated family protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
k59_157826_1	1266925.JHVX01000008_gene367	2.76e-123	365.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,372M3@32003|Nitrosomonadales	28216|Betaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_942041_1	159450.NH14_21025	2.94e-66	213.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,1K0W4@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	phaY2	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_713815_1	999541.bgla_2g21000	2.02e-12	70.9	COG0834@1|root,COG0834@2|Bacteria,1N6H5@1224|Proteobacteria,2VZJC@28216|Betaproteobacteria,1K5N1@119060|Burkholderiaceae	28216|Betaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02424	ko02010,map02010	M00234	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3.10,3.A.1.3.14	-	-	SBP_bac_3
k59_942043_1	1423144.Gal_00085	1.78e-20	94.7	COG0697@1|root,COG0697@2|Bacteria,1MXPW@1224|Proteobacteria,2U1CD@28211|Alphaproteobacteria,34F2J@302485|Phaeobacter	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
k59_681073_1	1229909.NSED_08980	9.01e-124	359.0	COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota	651137|Thaumarchaeota	F	aspartate carbamoyltransferase	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_222379_1	987059.RBXJA2T_05188	4.93e-81	256.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2VIV3@28216|Betaproteobacteria,1KIZE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_517538_1	1123277.KB893177_gene3581	1.1e-44	156.0	COG0697@1|root,COG0697@2|Bacteria,4NIDP@976|Bacteroidetes,47P0K@768503|Cytophagia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_647075_1	1121920.AUAU01000035_gene2752	4.11e-62	202.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,PA14
k59_189918_1	1121405.dsmv_0777	2.99e-79	251.0	COG0309@1|root,COG0546@1|root,COG0309@2|Bacteria,COG0546@2|Bacteria,1N04A@1224|Proteobacteria,437IA@68525|delta/epsilon subdivisions,2WYKF@28221|Deltaproteobacteria,2MP0D@213118|Desulfobacterales	28221|Deltaproteobacteria	O	AIR synthase related protein, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
k59_318762_1	1479237.JMLY01000001_gene1930	1.2e-32	117.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1S3WC@1236|Gammaproteobacteria,466YX@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
k59_318762_2	1131553.JIBI01000002_gene1837	2.04e-50	164.0	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2VRBU@28216|Betaproteobacteria,3736U@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_414665_1	999425.HMPREF9186_00489	2.04e-42	152.0	COG0687@1|root,COG0687@2|Bacteria,1TPY1@1239|Firmicutes,4HAET@91061|Bacilli	91061|Bacilli	P	spermidine putrescine ABC transporter	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	iSB619.SA_RS05395	SBP_bac_8
k59_713828_1	436308.Nmar_1528	2.54e-31	124.0	arCOG07561@1|root,arCOG07561@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TSP_3,VWA
k59_875391_1	159450.NH14_17815	2.55e-94	286.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,1K1XB@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	-	-	-	-	-	-	-	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_906968_1	1026882.MAMP_01391	5.97e-38	142.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,1T1IF@1236|Gammaproteobacteria,462AF@72273|Thiotrichales	1236|Gammaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,PAS,PAS_9
k59_942075_1	935863.AWZR01000003_gene2724	1.67e-46	161.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,1X4MM@135614|Xanthomonadales	135614|Xanthomonadales	O	peptidylprolyl	-	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
k59_974805_1	886293.Sinac_6023	1.2e-43	157.0	COG2239@1|root,COG2239@2|Bacteria,2IX38@203682|Planctomycetes	203682|Planctomycetes	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_93257_1	794903.OPIT5_30440	3.76e-60	208.0	COG0058@1|root,COG0058@2|Bacteria,46S5T@74201|Verrucomicrobia,3K731@414999|Opitutae	414999|Opitutae	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_844512_1	1000565.METUNv1_01234	1.52e-70	219.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2VNEC@28216|Betaproteobacteria,2KVSG@206389|Rhodocyclales	206389|Rhodocyclales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
k59_844512_2	391613.RTM1035_17825	3.1e-10	60.8	COG1117@1|root,COG1117@2|Bacteria,1QYBM@1224|Proteobacteria,2TXM9@28211|Alphaproteobacteria,46NG3@74030|Roseovarius	28211|Alphaproteobacteria	P	transport system, ATPase component	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
k59_746327_1	1123400.KB904817_gene1484	3.43e-20	83.6	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,460PX@72273|Thiotrichales	72273|Thiotrichales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_746327_2	713586.KB900536_gene1150	1.9e-65	212.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales	135613|Chromatiales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_125225_1	96561.Dole_2169	9.33e-54	178.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,2MJIU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_93260_2	365046.Rta_06910	5.37e-12	65.1	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,4A9S8@80864|Comamonadaceae	28216|Betaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_906982_1	1125863.JAFN01000001_gene2385	2.34e-08	53.5	COG0494@1|root,COG0494@2|Bacteria,1MYSK@1224|Proteobacteria	1224|Proteobacteria	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.17	ko:K01518	ko00230,ko00240,map00230,map00240	-	R00184,R00969,R01232,R02805	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_906982_2	1121106.JQKB01000016_gene5301	8.89e-18	84.7	COG0494@1|root,COG1670@1|root,COG0494@2|Bacteria,COG1670@2|Bacteria,1RCZM@1224|Proteobacteria,2U7A4@28211|Alphaproteobacteria,2JS44@204441|Rhodospirillales	204441|Rhodospirillales	JL	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Acetyltransf_3,NUDIX,NUDIX_4
k59_125229_1	864051.BurJ1DRAFT_3638	1.07e-121	358.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2VMDW@28216|Betaproteobacteria,1KJYJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027,ko:K10227	ko02010,map02010	M00200,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.5	-	-	SBP_bac_1,SBP_bac_8
k59_479571_2	401526.TcarDRAFT_2374	9.19e-61	201.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,4H37P@909932|Negativicutes	909932|Negativicutes	P	ammonium transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_450574_1	400682.PAC_15704178	8.48e-36	135.0	COG4231@1|root,2RJDJ@2759|Eukaryota,3AJAR@33154|Opisthokonta,3BXQU@33208|Metazoa	33208|Metazoa	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	POR
k59_251379_1	497321.C664_00520	4.36e-58	183.0	COG1795@1|root,COG1795@2|Bacteria,1NDRY@1224|Proteobacteria,2VJ22@28216|Betaproteobacteria,2KVWS@206389|Rhodocyclales	206389|Rhodocyclales	S	Formaldehyde-activating enzyme (Fae)	-	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
k59_251379_2	305700.B447_19034	3.54e-63	197.0	COG1795@1|root,COG1795@2|Bacteria,1NDRY@1224|Proteobacteria,2VJ22@28216|Betaproteobacteria,2KVWS@206389|Rhodocyclales	206389|Rhodocyclales	S	Formaldehyde-activating enzyme (Fae)	-	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
k59_647121_1	743299.Acife_0339	3.17e-08	54.7	COG3462@1|root,COG3462@2|Bacteria,1QD7Z@1224|Proteobacteria,1T955@1236|Gammaproteobacteria,2NDWN@225057|Acidithiobacillales	225057|Acidithiobacillales	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	-
k59_647121_2	880072.Desac_2074	3.87e-13	68.9	COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_479574_1	204669.Acid345_2268	4.03e-42	147.0	COG5395@1|root,COG5395@2|Bacteria,3Y9FU@57723|Acidobacteria,2JP81@204432|Acidobacteriia	204432|Acidobacteriia	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
k59_773939_1	402626.Rpic_2597	5.92e-68	230.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2VHW1@28216|Betaproteobacteria,1K153@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM surface antigen (D15)	tama	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_1025370_1	62928.azo1506	7.39e-33	127.0	COG4255@1|root,COG4255@2|Bacteria,1RA9X@1224|Proteobacteria,2WGEF@28216|Betaproteobacteria,2KZVS@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_773940_1	349161.Dred_3075	2.68e-43	153.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_582980_1	208439.AJAP_04045	2.04e-18	82.8	COG0494@1|root,COG0494@2|Bacteria,2IRKE@201174|Actinobacteria,4E6DM@85010|Pseudonocardiales	201174|Actinobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_582980_2	585502.HMPREF0645_1933	1.27e-13	71.2	COG0826@1|root,COG0826@2|Bacteria,4NEX7@976|Bacteroidetes,2FNE7@200643|Bacteroidia	976|Bacteroidetes	O	Peptidase, U32 family	prtQ	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
k59_479583_1	96561.Dole_0782	8.31e-19	82.8	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,42QX8@68525|delta/epsilon subdivisions,2WMNR@28221|Deltaproteobacteria,2MJNY@213118|Desulfobacterales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_479583_2	555079.Toce_0103	1.73e-43	152.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,42FE4@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM MazG family protein	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
k59_125251_1	795666.MW7_2454	2.08e-109	342.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1K5NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_318812_2	322710.Avin_49910	4.94e-05	45.1	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_746361_1	1417296.U879_19320	1.94e-33	128.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2VFWP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_974843_1	390989.JOEG01000004_gene3862	1.34e-07	58.5	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4D8Z7@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the ParB family	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_450601_1	1123290.AUDQ01000018_gene972	6e-16	83.6	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26EDB@186818|Planococcaceae	91061|Bacilli	E	COG0747 ABC-type dipeptide transport system, periplasmic component	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_318819_1	1000565.METUNv1_01932	4.11e-17	76.6	COG1795@1|root,COG1795@2|Bacteria,1MWYS@1224|Proteobacteria,2VNIQ@28216|Betaproteobacteria,2KWDW@206389|Rhodocyclales	206389|Rhodocyclales	S	Formaldehyde-activating enzyme (Fae)	-	-	-	-	-	-	-	-	-	-	-	-	Fae
k59_318819_2	1121127.JAFA01000013_gene2264	1.7e-57	190.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,1K01J@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN2	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_479590_1	1331660.L313_1317	1.65e-113	339.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,3NKXP@468|Moraxellaceae	1236|Gammaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_517627_1	671143.DAMO_0783	3.28e-52	169.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_773955_1	1232437.KL662016_gene1174	1.91e-90	271.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,43AA7@68525|delta/epsilon subdivisions,2X2GR@28221|Deltaproteobacteria,2MPBD@213118|Desulfobacterales	28221|Deltaproteobacteria	L	MULE transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_974850_2	883.DvMF_1512	7.86e-35	124.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria,2MCM3@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
k59_125264_1	396588.Tgr7_3022	2.99e-40	151.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_93299_1	1123278.KB893442_gene2629	0.000152	50.4	COG5492@1|root,COG5492@2|Bacteria,4NH7Q@976|Bacteroidetes,47MBP@768503|Cytophagia	976|Bacteroidetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	TIG
k59_980313_1	330214.NIDE2442	8.14e-74	236.0	COG0281@1|root,COG0281@2|Bacteria,3J0WV@40117|Nitrospirae	40117|Nitrospirae	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
k59_817201_1	1229909.NSED_08945	8.48e-79	260.0	COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota	651137|Thaumarchaeota	V	resistance protein	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
k59_588619_1	997296.PB1_09427	4.25e-50	180.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,1ZARC@1386|Bacillus	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_262124_1	398527.Bphyt_0616	2.7e-126	371.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,1K1RG@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_425283_1	330214.NIDE3745	3.36e-173	519.0	COG0474@1|root,COG0474@2|Bacteria,3J0YX@40117|Nitrospirae	40117|Nitrospirae	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_457916_1	398525.KB900701_gene2612	1.33e-58	197.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_23145	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_359952_1	420662.Mpe_A1217	1.72e-82	271.0	COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,2W0AD@28216|Betaproteobacteria,1KMY4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_294738_1	1132855.KB913035_gene184	4.66e-24	100.0	COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,2VS3H@28216|Betaproteobacteria,2KMGC@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_294738_2	1123487.KB892863_gene1915	2e-28	109.0	COG0819@1|root,COG0819@2|Bacteria,1MVA0@1224|Proteobacteria,2WGSW@28216|Betaproteobacteria,2KVR3@206389|Rhodocyclales	206389|Rhodocyclales	K	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
k59_66230_1	292415.Tbd_2366	2.48e-59	192.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,1KRM9@119069|Hydrogenophilales	119069|Hydrogenophilales	D	Cell division protein	-	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_849725_2	1239962.C943_03305	1.85e-30	114.0	2DFVU@1|root,2ZTDB@2|Bacteria,4P7KE@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_849725_3	307480.IW16_06290	7.01e-25	98.6	299U5@1|root,2ZWWA@2|Bacteria,4P8JU@976|Bacteroidetes,1IBVB@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_980330_1	945713.IALB_0345	5.49e-71	220.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_229388_1	436308.Nmar_0088	3.85e-112	349.0	COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_66242_1	1279009.ADICEAN_00065	5.08e-18	85.9	COG0116@1|root,COG0116@2|Bacteria,4NFJM@976|Bacteroidetes,47MFH@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the methyltransferase superfamily	rlmL	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
k59_719142_1	1231391.AMZF01000094_gene96	1.6e-77	241.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2VMW1@28216|Betaproteobacteria,3T349@506|Alcaligenaceae	28216|Betaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_294751_1	455436.DS989811_gene1565	7.25e-31	125.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,464RV@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	DALR_1,tRNA_synt_2f
k59_849738_1	563192.HMPREF0179_00647	4.39e-60	191.0	COG4577@1|root,COG4577@2|Bacteria,1R55P@1224|Proteobacteria,42RUF@68525|delta/epsilon subdivisions,2WNT1@28221|Deltaproteobacteria,2MB2A@213115|Desulfovibrionales	28221|Deltaproteobacteria	CQ	BMC	-	-	-	-	-	-	-	-	-	-	-	-	BMC
k59_425308_1	228410.NE0152	1.77e-27	112.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,372K6@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_425308_2	1163617.SCD_n01807	7.19e-46	155.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,2VSHE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
k59_653980_3	1122201.AUAZ01000004_gene3399	2.57e-14	73.9	2DURB@1|root,32UXN@2|Bacteria,1N0HD@1224|Proteobacteria,1S3KR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_653980_5	268746.Q58MN4_BPPRM	1.84e-09	65.9	4QDYQ@10239|Viruses,4QVVQ@35237|dsDNA viruses  no RNA stage,4QPVQ@28883|Caudovirales,4QKJF@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_943_1	66874.JOFS01000035_gene622	6.97e-11	67.8	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_653982_1	395494.Galf_1181	3.21e-113	338.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,44WDG@713636|Nitrosomonadales	28216|Betaproteobacteria	KLT	PFAM Serine threonine-protein kinase-like domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
k59_588656_2	595536.ADVE02000001_gene1160	2.66e-09	58.2	COG2197@1|root,COG2197@2|Bacteria,1R2TM@1224|Proteobacteria,2TU4S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	response regulator	MA20_20785	-	-	ko:K07684,ko:K07693	ko02020,map02020	M00471,M00479	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_164176_1	247634.GPB2148_352	1.48e-96	296.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1J4DQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_425314_2	204669.Acid345_4506	1.1e-08	60.1	COG0304@1|root,COG0304@2|Bacteria,3Y3IS@57723|Acidobacteria,2JIGI@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_66277_1	269796.Rru_A2576	1.88e-76	250.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria,2JPD9@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_98905_1	1502770.JQMG01000001_gene744	1.7e-08	55.5	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,2KM28@206350|Nitrosomonadales	206350|Nitrosomonadales	HJ	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_98905_2	1485544.JQKP01000002_gene1566	6.22e-232	647.0	COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,2VHD9@28216|Betaproteobacteria,44V1Q@713636|Nitrosomonadales	28216|Betaproteobacteria	U	Glutamate-cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GshA
k59_98905_3	497321.C664_11830	2.84e-122	355.0	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,2KVJ6@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_N
k59_425328_1	1121405.dsmv_0507	2.42e-77	245.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42YHK@68525|delta/epsilon subdivisions,2WUDF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_963_1	1268303.RHODMAR_3478	3.68e-84	258.0	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria,4FYKI@85025|Nocardiaceae	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
k59_131553_2	1210045.ALNP01000002_gene4184	2.78e-05	48.9	COG2172@1|root,COG2172@2|Bacteria,2IFV3@201174|Actinobacteria	201174|Actinobacteria	T	Anti-sigma regulatory factor (Ser Thr protein kinase)	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
k59_947769_1	292415.Tbd_1756	2.04e-58	183.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2VRG9@28216|Betaproteobacteria,1KRM7@119069|Hydrogenophilales	119069|Hydrogenophilales	O	SmpB protein	-	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_947769_2	261292.Nit79A3_2372	3.55e-59	186.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,3737J@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Polyketide cyclase / dehydrase and lipid transport	ratA	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_621321_2	314345.SPV1_06954	3.93e-25	105.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria	1224|Proteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006996,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009657,GO:0009668,GO:0009987,GO:0010027,GO:0016043,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0061024,GO:0071704,GO:0071840,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365	Ketoacyl-synt_C,ketoacyl-synt
k59_621322_1	383381.EH30_10190	3.03e-65	215.0	COG4638@1|root,COG4638@2|Bacteria,1R4IX@1224|Proteobacteria,2U0IQ@28211|Alphaproteobacteria,2K1CE@204457|Sphingomonadales	204457|Sphingomonadales	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
k59_947774_1	1437824.BN940_12476	9.88e-98	297.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,3T23Q@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the formation of L-threonine from O-phospho-L-homoserine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_980372_1	288000.BBta_3243	2.13e-10	60.5	COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2TUUS@28211|Alphaproteobacteria,3JUFJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Cupin domain	-	-	1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R02656	RC00764	ko00000,ko00001,ko01000	-	-	-	Cupin_2
k59_980372_2	365044.Pnap_2456	4.51e-71	221.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2VMC0@28216|Betaproteobacteria,4ABMQ@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_425336_1	999541.bgla_1g33990	2.54e-56	189.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,1K0BX@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_523392_1	1158292.JPOE01000002_gene1439	6.88e-148	447.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1KJ1Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_719196_1	391625.PPSIR1_21759	3.55e-13	75.1	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42NYJ@68525|delta/epsilon subdivisions,2WKYM@28221|Deltaproteobacteria,2YWVI@29|Myxococcales	28221|Deltaproteobacteria	C	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppsA1	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_33634_1	926569.ANT_16580	2.22e-102	320.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi	200795|Chloroflexi	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_817288_1	1158292.JPOE01000002_gene1539	1.85e-86	270.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KKE0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Sigma-54 interaction domain	hoxA	-	-	ko:K19641	ko02020,map02020	M00772	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_817288_2	864051.BurJ1DRAFT_1600	3.94e-82	253.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VKE2@28216|Betaproteobacteria,1KJP6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase, 20	hoxB	-	1.12.7.2,1.12.99.6	ko:K00534,ko:K06282	ko00633,ko01120,map00633,map01120	-	R00019,R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_294801_1	105559.Nwat_0547	8.5e-113	353.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales	135613|Chromatiales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_882342_1	1415778.JQMM01000001_gene2181	1.48e-118	353.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA1	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_588698_1	288000.BBta_1460	1.38e-133	399.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_751749_1	1288494.EBAPG3_21530	1.52e-73	234.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,371YK@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_196937_1	743719.PaelaDRAFT_0686	1.32e-44	161.0	COG2304@1|root,COG2304@2|Bacteria,1U8R5@1239|Firmicutes,4HE3R@91061|Bacilli,26RYW@186822|Paenibacillaceae	91061|Bacilli	S	Von Willebrand factor	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	SBP_bac_11,VWA
k59_915213_1	926569.ANT_22690	4.06e-29	118.0	COG1132@1|root,COG1132@2|Bacteria,2G7KM@200795|Chloroflexi	200795|Chloroflexi	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_686652_1	450851.PHZ_c1734	4.96e-38	147.0	COG4122@1|root,COG4122@2|Bacteria,1QWCT@1224|Proteobacteria,2TYCV@28211|Alphaproteobacteria,2KHS8@204458|Caulobacterales	204458|Caulobacterales	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_98953_1	269799.Gmet_1414	3e-15	70.1	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,42REF@68525|delta/epsilon subdivisions,2WQ4F@28221|Deltaproteobacteria,43UVT@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_98953_2	97139.C824_03113	2.08e-23	90.5	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,36MNG@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_621355_1	748247.AZKH_2008	6.94e-110	321.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,2VIWG@28216|Betaproteobacteria,2KX26@206389|Rhodocyclales	206389|Rhodocyclales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_849800_1	330214.NIDE4063	3.56e-117	344.0	COG1748@1|root,COG1748@2|Bacteria	2|Bacteria	E	saccharopine dehydrogenase activity	lysDH	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
k59_164245_1	1116375.VEJY3_18501	3.69e-90	273.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,1RMBA@1236|Gammaproteobacteria,1XUR9@135623|Vibrionales	135623|Vibrionales	E	COG0620 Methionine synthase II (cobalamin-independent)	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_425370_1	1286106.MPL1_11975	4.2e-22	95.5	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,4604F@72273|Thiotrichales	72273|Thiotrichales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_425370_2	640513.Entas_2444	9.8e-33	127.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,3X0E8@547|Enterobacter	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404	GlutR_N,GlutR_dimer,Shikimate_DH
k59_458025_1	56780.SYN_02213	1.44e-68	229.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_196961_1	228410.NE1489	2.13e-81	249.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VIFE@28216|Betaproteobacteria,371U2@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_196961_2	748247.AZKH_0539	1.88e-39	140.0	COG5486@1|root,COG5486@2|Bacteria,1R6FN@1224|Proteobacteria,2VMCU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
k59_915231_2	1288494.EBAPG3_29140	2.19e-36	125.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,373AG@32003|Nitrosomonadales	28216|Betaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_915231_3	1131553.JIBI01000011_gene744	1.04e-25	102.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,372ZX@32003|Nitrosomonadales	28216|Betaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_360050_1	94624.Bpet4807	1.09e-99	302.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,3T1UE@506|Alcaligenaceae	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_686677_1	1380355.JNIJ01000007_gene3229	3.18e-28	113.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2UPGN@28211|Alphaproteobacteria,3K2V1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_720271_2	228410.NE2073	9.33e-219	618.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,371YV@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_720271_3	1485544.JQKP01000002_gene1497	6.08e-37	136.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,44VJ6@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_458877_1	1266925.JHVX01000003_gene462	1.86e-106	332.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,3729D@32003|Nitrosomonadales	28216|Betaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_230374_1	404589.Anae109_1032	2.34e-53	189.0	COG4262@1|root,COG4262@2|Bacteria	2|Bacteria	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,Spermine_synth
k59_263288_1	323848.Nmul_A0453	5.77e-159	459.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,371RP@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_589738_2	1265313.HRUBRA_02306	2.28e-53	182.0	COG0167@1|root,COG0543@1|root,COG0167@2|Bacteria,COG0543@2|Bacteria,1MU7C@1224|Proteobacteria	1224|Proteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,DHO_dh,NAD_binding_1
k59_271226_1	338969.Rfer_0216	4.39e-78	247.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,4AC26@80864|Comamonadaceae	28216|Betaproteobacteria	I	Benzoate-CoA ligase family	-	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_205775_1	330214.NIDE4091	1.06e-46	174.0	COG3419@1|root,COG3419@2|Bacteria,3J100@40117|Nitrospirae	40117|Nitrospirae	NU	Tfp pilus assembly protein tip-associated adhesin	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_630267_1	1163409.UUA_14524	2.25e-58	188.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,1X4FI@135614|Xanthomonadales	135614|Xanthomonadales	O	protein-L-isoaspartate O-methyltransferase	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_663358_1	472759.Nhal_1758	8.43e-71	230.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1X0G4@135613|Chromatiales	135613|Chromatiales	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_108126_1	205922.Pfl01_3910	2.8e-50	170.0	COG0583@1|root,COG0583@2|Bacteria,1MWUD@1224|Proteobacteria,1S5SM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_890751_1	945713.IALB_2314	5.99e-20	94.4	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
k59_957055_1	983917.RGE_01150	8.27e-18	82.8	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,1KK5P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	methylmalonate-semialdehyde dehydrogenase	mmsA_2	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_42719_1	272568.GDI2986	9.45e-33	119.0	COG3293@1|root,COG3293@2|Bacteria,1RFRK@1224|Proteobacteria,2U8TH@28211|Alphaproteobacteria,2JTJP@204441|Rhodospirillales	204441|Rhodospirillales	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_529082_1	69279.BG36_07140	2.51e-06	54.3	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2V7D9@28211|Alphaproteobacteria,43KPE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
k59_271243_2	1304883.KI912532_gene2979	7.29e-124	378.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,2KV41@206389|Rhodocyclales	206389|Rhodocyclales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_890756_1	1123367.C666_10230	2.26e-102	327.0	COG0744@1|root,COG0744@2|Bacteria,1NRPB@1224|Proteobacteria,2VJ7F@28216|Betaproteobacteria,2KVVR@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0744 Membrane carboxypeptidase (penicillin-binding protein)	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_303233_1	1229205.BUPH_03471	3.87e-66	208.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,1K3A8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	response regulator	basR_3	-	-	ko:K02483,ko:K07666,ko:K07774	ko02020,ko02024,map02020,map02024	M00453,M00457	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_597814_1	392499.Swit_0762	1.81e-110	337.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2V929@28211|Alphaproteobacteria,2K9IC@204457|Sphingomonadales	204457|Sphingomonadales	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
k59_630290_1	459495.SPLC1_S100190	2.33e-35	133.0	COG1752@1|root,COG1752@2|Bacteria,1G2F8@1117|Cyanobacteria,1HEP7@1150|Oscillatoriales	1117|Cyanobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_236886_1	640081.Dsui_0513	9.28e-81	263.0	COG2199@1|root,COG2199@2|Bacteria,1QTT5@1224|Proteobacteria,2VKM3@28216|Betaproteobacteria,2KY09@206389|Rhodocyclales	206389|Rhodocyclales	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
k59_759146_1	1122194.AUHU01000003_gene2023	2.38e-78	247.0	COG0477@1|root,COG2814@2|Bacteria,1MVKJ@1224|Proteobacteria,1RMHJ@1236|Gammaproteobacteria,464EA@72275|Alteromonadaceae	1236|Gammaproteobacteria	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	xylE	GO:0003674,GO:0005215,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015519,GO:0015672,GO:0015749,GO:0015750,GO:0015753,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	-	ko:K05548,ko:K08138,ko:K08139	ko04113,map04113	-	-	-	ko00000,ko00001,ko02000	2.A.1.1,2.A.1.1.3,2.A.1.15	-	iECIAI1_1343.ECIAI1_4259,iECSE_1348.ECSE_4322	Sugar_tr
k59_140795_1	187272.Mlg_2675	9.94e-40	150.0	COG2905@1|root,COG5001@1|root,COG2905@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X0A7@135613|Chromatiales	135613|Chromatiales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,PAS_9
k59_368877_1	468059.AUHA01000010_gene2828	9.16e-13	69.3	COG3547@1|root,COG3547@2|Bacteria,4NGED@976|Bacteroidetes,1IQ9F@117747|Sphingobacteriia	976|Bacteroidetes	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_565429_1	339670.Bamb_0857	2.31e-109	320.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2VIGI@28216|Betaproteobacteria,1K0EK@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_786811_1	429009.Adeg_0968	1.24e-44	156.0	COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,247TI@186801|Clostridia,42F3J@68295|Thermoanaerobacterales	186801|Clostridia	J	SMART PUA domain containing protein	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,PUA
k59_786811_2	1236541.BALL01000018_gene2466	5.01e-06	48.5	COG4946@1|root,COG4946@2|Bacteria,1QXRE@1224|Proteobacteria,1T3HK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40
k59_140804_2	1265505.ATUG01000001_gene3615	2.18e-19	90.1	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42PH1@68525|delta/epsilon subdivisions,2WKMX@28221|Deltaproteobacteria,2MJE1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_630308_1	765910.MARPU_07215	1.55e-58	196.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales	135613|Chromatiales	M	Cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_205818_1	765913.ThidrDRAFT_2111	4.99e-74	227.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1WWJX@135613|Chromatiales	135613|Chromatiales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
k59_1016779_1	497321.C664_02575	4.45e-68	217.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,2KVD3@206389|Rhodocyclales	206389|Rhodocyclales	E	TOBE domain	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
k59_173445_1	1392838.AWNM01000054_gene2982	1.54e-45	158.0	COG2890@1|root,COG2890@2|Bacteria,1MY5I@1224|Proteobacteria,2W2X5@28216|Betaproteobacteria,3T98E@506|Alcaligenaceae	28216|Betaproteobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_205826_3	864051.BurJ1DRAFT_2338	6.58e-67	215.0	COG3500@1|root,COG3500@2|Bacteria,1R67C@1224|Proteobacteria,2VUST@28216|Betaproteobacteria,1KMXF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
k59_858634_1	1123393.KB891327_gene424	1.44e-122	358.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,1KS4D@119069|Hydrogenophilales	119069|Hydrogenophilales	Q	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_858634_2	402777.KB235904_gene4246	1.19e-13	72.8	COG0517@1|root,COG2199@1|root,COG4251@1|root,COG0517@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,1FZWU@1117|Cyanobacteria,1H8MG@1150|Oscillatoriales	1117|Cyanobacteria	T	GGDEF domain'	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,GGDEF,PAS_3,PAS_4,PAS_8,PAS_9
k59_271288_1	511.JT27_05825	3.64e-59	191.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,3T1UN@506|Alcaligenaceae	28216|Betaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_728642_1	472759.Nhal_3349	8.72e-14	77.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_696179_2	1340493.JNIF01000003_gene4501	3.72e-05	43.1	COG0776@1|root,COG0776@2|Bacteria,3Y4U2@57723|Acidobacteria	57723|Acidobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_890811_1	945713.IALB_0633	2.65e-51	169.0	COG1127@1|root,COG1127@2|Bacteria	2|Bacteria	Q	ATPase activity	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_890811_2	945713.IALB_0632	1.12e-37	134.0	COG0767@1|root,COG0767@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_368918_1	305700.B447_03088	1.23e-50	169.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VHWQ@28216|Betaproteobacteria,2KVJ9@206389|Rhodocyclales	206389|Rhodocyclales	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_368918_2	675814.VIC_000401	4.27e-08	54.3	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1XSWD@135623|Vibrionales	135623|Vibrionales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_924630_1	1121035.AUCH01000012_gene3022	5.99e-41	153.0	COG1352@1|root,COG5001@1|root,COG1352@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVWQ@206389|Rhodocyclales	206389|Rhodocyclales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS_4
k59_205842_1	395494.Galf_1784	2.19e-51	169.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,44VX8@713636|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM outer membrane chaperone Skp (OmpH)	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_434109_1	1122603.ATVI01000005_gene3042	3.34e-41	145.0	COG0668@1|root,COG0668@2|Bacteria,1N4UN@1224|Proteobacteria,1T9TX@1236|Gammaproteobacteria,1XBUR@135614|Xanthomonadales	135614|Xanthomonadales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_10429_1	509190.Cseg_0713	1.23e-32	127.0	COG1680@1|root,COG1680@2|Bacteria,1R49D@1224|Proteobacteria,2U4UG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase class C	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_759179_2	880073.Calab_0995	1.3e-60	194.0	COG0501@1|root,COG0501@2|Bacteria,2NS4G@2323|unclassified Bacteria	2|Bacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_663435_1	3750.XP_008354068.1	1.61e-62	221.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37RKK@33090|Viridiplantae,3GFFM@35493|Streptophyta	35493|Streptophyta	S	2S seed storage protein 5-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Tryp_alpha_amyl
k59_271295_2	1198452.Jab_2c02510	3.21e-65	209.0	2EMEM@1|root,33F3F@2|Bacteria,1NK08@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_500253_1	996637.SGM_4637	0.000864	42.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria	201174|Actinobacteria	S	adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_500253_2	1547437.LL06_21140	1.15e-30	117.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2U6J3@28211|Alphaproteobacteria,43RKD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Sigma-70 region 2	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_826731_1	270374.MELB17_14111	3.46e-75	243.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,4658U@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG3267 Type II secretory pathway, component ExeA	gspA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_303291_1	399795.CtesDRAFT_PD5244	7.09e-49	168.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJCY@28216|Betaproteobacteria,4ABM4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_42782_1	1121448.DGI_2643	3.31e-67	218.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_924633_1	1454004.AW11_02857	9.43e-248	695.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria	1224|Proteobacteria	CP	formate hydrogenlyase subunit 3 multisubunit Na H antiporter, MnhD subunit	nuoL3	-	-	ko:K05568,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_858651_1	293826.Amet_3897	5.59e-24	101.0	COG3415@1|root,COG3415@2|Bacteria,1U5WP@1239|Firmicutes,24RC3@186801|Clostridia	186801|Clostridia	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_858651_2	222534.KB893755_gene4252	1.81e-66	209.0	COG3335@1|root,COG3335@2|Bacteria,2GK01@201174|Actinobacteria,4EV9T@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_597880_2	639283.Snov_1192	3.15e-10	60.1	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3F1UF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_368931_1	317013.NY99_17620	2.34e-93	292.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1X34U@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_500265_1	640081.Dsui_1319	2.4e-88	271.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,2KUZY@206389|Rhodocyclales	206389|Rhodocyclales	U	type II secretion system protein	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_924642_1	1046714.AMRX01000006_gene2656	3.34e-05	49.3	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	gspB	-	-	ko:K02451	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	DUF3391,T2SSB
k59_696208_1	639283.Snov_0228	3.58e-71	226.0	COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2TT7P@28211|Alphaproteobacteria,3F105@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	6-phosphogluconate dehydrogenase NAD-binding	MA20_16450	-	1.1.1.411	ko:K08319	-	-	-	-	ko00000,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_565481_1	1190603.AJYD01000008_gene2166	1.51e-31	119.0	COG0454@1|root,COG0456@2|Bacteria,1N4MF@1224|Proteobacteria,1S66R@1236|Gammaproteobacteria,1XWDA@135623|Vibrionales	135623|Vibrionales	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_826748_1	694431.DESACE_02525	2.28e-64	217.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Glycosyl transferase, family 20	otsAB	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,S6PP,Trehalose_PPase
k59_368946_1	243231.GSU1594	3.48e-61	201.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,43TZJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM peptidase M16 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_141837_1	396588.Tgr7_0968	2.02e-43	159.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_566432_2	472759.Nhal_1348	7.87e-20	90.1	COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria,1SJKT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_435075_1	864073.HFRIS_012169	3.91e-242	680.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,472N5@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_76824_1	1278309.KB907101_gene327	1.32e-115	351.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1XIGC@135619|Oceanospirillales	135619|Oceanospirillales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_566439_1	237368.SCABRO_00954	2.51e-113	342.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_664471_1	420662.Mpe_A0716	4.94e-78	236.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2VQ1Q@28216|Betaproteobacteria,1KKTQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_664471_2	859657.RPSI07_3052	4.17e-16	77.4	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,1JZX1@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_631265_1	335543.Sfum_0451	2.14e-64	223.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MR8V@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_958167_1	1163617.SCD_n02416	6.32e-44	154.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_958167_2	743722.Sph21_0877	6.47e-28	114.0	COG3509@1|root,COG3509@2|Bacteria,4NHFS@976|Bacteroidetes,1ITGP@117747|Sphingobacteriia	976|Bacteroidetes	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Abhydrolase_2,Esterase_phd
k59_501264_1	1268237.G114_02609	1.13e-78	244.0	COG1176@1|root,COG1176@2|Bacteria,1NU6V@1224|Proteobacteria,1RZ7V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC transporter (Permease	ydcU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	iEcSMS35_1347.EcSMS35_1732	BPD_transp_1
k59_990080_1	95619.PM1_0204690	4.61e-43	161.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_43796_1	1123393.KB891326_gene42	2.11e-79	265.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,1KSRI@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_237731_1	383381.EH30_15565	1.02e-22	97.4	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria,2K01U@204457|Sphingomonadales	204457|Sphingomonadales	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_472991_1	1227453.C444_05121	5.74e-07	55.5	arCOG02703@1|root,arCOG02703@2157|Archaea,2XV0I@28890|Euryarchaeota,23SUR@183963|Halobacteria	183963|Halobacteria	Q	Methyltransferase type 11	aknG	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_1021390_1	1123487.KB892838_gene3825	1.89e-191	556.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,2KV41@206389|Rhodocyclales	206389|Rhodocyclales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_867722_1	1336243.JAEA01000009_gene163	1.42e-90	291.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,1JSF2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_867722_2	1163617.SCD_n01708	2.66e-87	266.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2VHJ3@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	cbbY	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_867722_3	765910.MARPU_02205	1.45e-40	142.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,1RNFF@1236|Gammaproteobacteria,1WXJM@135613|Chromatiales	135613|Chromatiales	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	-	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
k59_85199_1	396588.Tgr7_3257	4.32e-15	74.3	2DKHM@1|root,309GY@2|Bacteria,1RFJ6@1224|Proteobacteria,1S4EG@1236|Gammaproteobacteria,1X1R5@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_85199_2	1123401.JHYQ01000012_gene2888	2.18e-21	91.3	COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,1T212@1236|Gammaproteobacteria,45ZU6@72273|Thiotrichales	72273|Thiotrichales	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	ThiI
k59_966645_1	1217720.ALOX01000052_gene1529	1.32e-33	129.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JSUV@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_966645_2	883078.HMPREF9695_03134	4.91e-41	144.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TTJF@28211|Alphaproteobacteria,3JT56@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_672971_2	1429851.X548_11920	1.25e-44	146.0	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,1X7QC@135614|Xanthomonadales	135614|Xanthomonadales	S	BolA family transcriptional regulator	yciI	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_639385_1	1114856.C496_12087	3.84e-13	71.2	COG3387@1|root,arCOG03286@2157|Archaea,2XUKJ@28890|Euryarchaeota,23SKS@183963|Halobacteria	183963|Halobacteria	G	COG3387 Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_934061_1	1198452.Jab_2c21380	3.62e-33	131.0	COG2831@1|root,COG2831@2|Bacteria,1PRBP@1224|Proteobacteria,2VHDS@28216|Betaproteobacteria,475Q6@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Hemolysin activation secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	POTRA,POTRA_2,ShlB
k59_899475_1	1120950.KB892779_gene987	1.99e-44	154.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4DP5D@85009|Propionibacteriales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_407908_1	1085623.GNIT_3056	3.1e-26	112.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,464DA@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Peptidase, M13	pepO	-	3.4.24.71	ko:K01415,ko:K07386	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_639390_1	105559.Nwat_2323	1.4e-51	177.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Sigma54_activat
k59_998172_1	62928.azo3673	2.13e-49	172.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,2KW6A@206389|Rhodocyclales	206389|Rhodocyclales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_998172_2	596154.Alide2_3898	3.44e-47	168.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4A9SZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_607040_1	743299.Acife_1823	1.43e-121	355.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,2NC8X@225057|Acidithiobacillales	225057|Acidithiobacillales	O	hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_790302_1	1121937.AUHJ01000017_gene3005	7.38e-15	73.2	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,466JA@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_790302_2	876044.IMCC3088_857	5.64e-50	172.0	COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Secreted protein, containing von Willebrand factor (VWF) type	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_867745_1	880073.Calab_1785	1.14e-60	207.0	COG0709@1|root,COG1104@1|root,COG0709@2|Bacteria,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	selD	-	2.7.9.3,2.8.1.7	ko:K01008,ko:K04487	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03595,R07460,R11528,R11529	RC00002,RC01789,RC02313,RC02878	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	AIRS,AIRS_C,Aminotran_5
k59_934077_2	1163617.SCD_n01211	1.22e-68	219.0	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2VN4W@28216|Betaproteobacteria	28216|Betaproteobacteria	S	DMSO reductase anchor subunit (DmsC)	dmsC	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
k59_766988_1	1120941.AUBL01000013_gene463	0.000857	41.2	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4D3YV@85005|Actinomycetales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_766988_2	469381.Dpep_0961	9.85e-12	67.8	COG1739@1|root,COG1739@2|Bacteria,3TB8F@508458|Synergistetes	508458|Synergistetes	S	YigZ family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0029
k59_407926_1	330214.NIDE4127	4.82e-118	358.0	COG1185@1|root,COG1185@2|Bacteria,3J0DX@40117|Nitrospirae	40117|Nitrospirae	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_867756_1	266265.Bxe_A3199	6.25e-08	54.3	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,2VRU5@28216|Betaproteobacteria,1K3Z8@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_867756_2	696747.NIES39_A04370	1.49e-08	57.0	COG0306@1|root,COG0306@2|Bacteria	2|Bacteria	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_214922_1	1380391.JIAS01000015_gene333	4.98e-19	80.1	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,2JSSH@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
k59_214922_2	62928.azo0988	6.79e-35	132.0	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales	206389|Rhodocyclales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
k59_738268_1	307480.IW16_13140	2.08e-26	107.0	COG2761@1|root,COG2761@2|Bacteria,4NJ3N@976|Bacteroidetes,1HXDF@117743|Flavobacteriia,3ZNN6@59732|Chryseobacterium	976|Bacteroidetes	Q	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_738268_2	1157708.KB907454_gene3113	0.000245	42.7	COG1028@1|root,COG1028@2|Bacteria,1R6C1@1224|Proteobacteria,2VP97@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_899506_1	1121413.JMKT01000002_gene2646	9.33e-60	208.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2M8T9@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_473030_1	426114.THI_0950	6.81e-10	60.8	COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,2VS06@28216|Betaproteobacteria	28216|Betaproteobacteria	I	6-phosphogluconate dehydrogenase, NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_473030_2	196367.JNFG01000008_gene6597	1.7e-42	149.0	COG1082@1|root,COG1082@2|Bacteria,1NHXC@1224|Proteobacteria,2VRSG@28216|Betaproteobacteria,1K889@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_85243_1	1168065.DOK_15069	6.51e-71	224.0	COG2141@1|root,COG2141@2|Bacteria,1R7K1@1224|Proteobacteria,1RNSC@1236|Gammaproteobacteria,1J5HQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_574859_1	243365.CV_3231	1.58e-49	165.0	2C1BX@1|root,307EB@2|Bacteria,1MY9B@1224|Proteobacteria,2VRW7@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_51877_1	335543.Sfum_3200	1.69e-56	189.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MRB7@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_443045_1	768671.ThimaDRAFT_2349	2.4e-21	86.7	2ECSY@1|root,336QI@2|Bacteria,1N9AZ@1224|Proteobacteria,1S9XM@1236|Gammaproteobacteria,1WYWD@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_443045_2	765910.MARPU_02230	1.62e-36	130.0	COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,1WX61@135613|Chromatiales	135613|Chromatiales	S	PKHD-type hydroxylase	-	-	-	ko:K07336	-	-	-	-	ko00000,ko01000	-	-	-	2OG-FeII_Oxy_3
k59_150203_1	666681.M301_1431	6.49e-42	149.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,2KKWN@206350|Nitrosomonadales	206350|Nitrosomonadales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_150203_2	1121920.AUAU01000006_gene370	4.24e-20	83.2	COG3369@1|root,COG3369@2|Bacteria	2|Bacteria	I	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
k59_117532_1	335543.Sfum_3720	4.55e-08	59.7	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria,2MQE0@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_836385_1	420324.KI912043_gene4024	1.9e-28	112.0	COG2984@1|root,COG2984@2|Bacteria,1RDUT@1224|Proteobacteria,2U8XC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_868709_1	1408445.JHXP01000003_gene1138	5.57e-68	220.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RPIE@1236|Gammaproteobacteria,1JCJS@118969|Legionellales	118969|Legionellales	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_575789_1	1395516.PMO01_05450	1.2e-10	65.5	COG4675@1|root,COG5301@1|root,COG4675@2|Bacteria,COG5301@2|Bacteria,1MWNN@1224|Proteobacteria,1S2BE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phage tail-collar fibre protein	-	-	-	-	-	-	-	-	-	-	-	-	Collar,DUF3751
k59_245449_1	1266925.JHVX01000016_gene170	4.31e-139	405.0	COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,2VHD9@28216|Betaproteobacteria,372GW@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Glutamate-cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GshA
k59_999116_1	502025.Hoch_2055	7.77e-19	83.6	COG2085@1|root,COG2085@2|Bacteria,1NF95@1224|Proteobacteria,4380B@68525|delta/epsilon subdivisions,2X3AC@28221|Deltaproteobacteria,2YURK@29|Myxococcales	28221|Deltaproteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_999116_2	1341151.ASZU01000004_gene203	2.19e-06	49.7	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,4H9T1@91061|Bacilli,27BIN@186824|Thermoactinomycetaceae	91061|Bacilli	M	Mur ligase family, glutamate ligase domain	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_443977_1	38727.Pavir.J05007.1.p	1.16e-10	67.8	2CMXP@1|root,2QSKB@2759|Eukaryota,37QF5@33090|Viridiplantae,3GF7C@35493|Streptophyta,3KTBB@4447|Liliopsida,3I2JI@38820|Poales	35493|Streptophyta	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_443977_2	644801.Psest_2161	2.62e-40	141.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,1RNSP@1236|Gammaproteobacteria,1Z076@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	Endonuclease Exonuclease phosphatase	ybhP	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_767823_1	713586.KB900536_gene2604	5.74e-21	92.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_767823_2	1577887.JSYG01000026_gene391	1.75e-41	141.0	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,2JDH8@204037|Dickeya	1236|Gammaproteobacteria	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
k59_935055_1	945713.IALB_2618	6.3e-134	390.0	COG3033@1|root,COG3033@2|Bacteria	2|Bacteria	E	tryptophanase activity	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_967670_1	1229909.NSED_03395	2.83e-104	320.0	COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_276565_1	640081.Dsui_1700	6.25e-61	196.0	COG3821@1|root,COG3821@2|Bacteria,1RDXR@1224|Proteobacteria,2VKFZ@28216|Betaproteobacteria,2KW9C@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function, DUF599	-	-	-	-	-	-	-	-	-	-	-	-	DUF599
k59_900412_1	59538.XP_005968778.1	6.63e-88	270.0	COG1062@1|root,KOG0022@2759|Eukaryota,397PJ@33154|Opisthokonta,3BIQH@33208|Metazoa,3CYWE@33213|Bilateria,4871P@7711|Chordata,491PB@7742|Vertebrata,3J1Y5@40674|Mammalia	2759|Eukaryota	Q	alcohol dehydrogenase (NAD) activity	ADH1	GO:0000302,GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009410,GO:0009413,GO:0009414,GO:0009415,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009737,GO:0009743,GO:0009744,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0014074,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0031000,GO:0032355,GO:0033993,GO:0034285,GO:0036270,GO:0036293,GO:0042221,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043279,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046686,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065007,GO:0070482,GO:0071944,GO:0080134,GO:0080135,GO:0097305,GO:1900037,GO:1900039,GO:1901698,GO:1901700	1.1.1.1,1.1.1.284	ko:K00001,ko:K00121,ko:K02267,ko:K13980,ko:K18857	ko00010,ko00071,ko00190,ko00350,ko00592,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,ko05204,map00010,map00071,map00190,map00350,map00592,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map04260,map04714,map04932,map05010,map05012,map05016,map05204	M00154	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310,R10783	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	3.D.4.11,3.D.4.8	-	-	ADH_N,ADH_zinc_N
k59_86220_1	266264.Rmet_0217	4.02e-22	94.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VHRM@28216|Betaproteobacteria,1K669@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_86220_2	640081.Dsui_1112	2.18e-58	194.0	COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2VI33@28216|Betaproteobacteria,2KVMF@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_534165_1	94624.Bpet3438	4.71e-27	108.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,3T60T@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_534165_2	652103.Rpdx1_3913	2.84e-52	176.0	COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2TV0U@28211|Alphaproteobacteria,3JQXP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	N-terminal half of MaoC dehydratase	MA20_04520	-	4.2.1.153	ko:K09709	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00376	R09282	RC02479	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
k59_767835_1	102107.XP_008222215.1	3.19e-26	112.0	COG0402@1|root,KOG3968@2759|Eukaryota,37RVI@33090|Viridiplantae,3GFQR@35493|Streptophyta,4JGHE@91835|fabids	35493|Streptophyta	FQ	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_312617_1	1280952.HJA_09824	2.88e-71	228.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,43W7I@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_118482_1	228410.NE0993	4.48e-16	77.4	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,3725K@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_118482_2	365046.Rta_09710	5.18e-49	169.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,4AA6E@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_118485_1	1173029.JH980292_gene2096	3.29e-32	129.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_86233_1	1123487.KB892868_gene1159	4.18e-08	50.4	2CI9F@1|root,33H5J@2|Bacteria,1NH1E@1224|Proteobacteria,2VXVR@28216|Betaproteobacteria,2KXJZ@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_86233_2	443144.GM21_3094	3.28e-40	139.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_837376_1	269799.Gmet_0917	2.17e-25	110.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,43TII@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	SurA N-terminal domain	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_444014_1	543913.D521_0671	1.62e-13	68.9	COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,1KQNK@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	LrgB-like family	yohK	-	-	-	-	-	-	-	-	-	-	-	LrgB
k59_444014_2	1122236.KB905143_gene198	2.08e-27	104.0	COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,2VTZY@28216|Betaproteobacteria,2KN1K@206350|Nitrosomonadales	206350|Nitrosomonadales	S	LrgA family	-	-	-	-	-	-	-	-	-	-	-	-	LrgA
k59_444014_3	1038859.AXAU01000033_gene111	3e-11	63.9	COG3485@1|root,COG3485@2|Bacteria,1MV6K@1224|Proteobacteria,2TUS4@28211|Alphaproteobacteria,3JV34@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C
k59_868761_1	631362.Thi970DRAFT_04636	1.97e-60	197.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,1RRAG@1236|Gammaproteobacteria,1WY6I@135613|Chromatiales	135613|Chromatiales	I	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_215879_1	1049564.TevJSym_aa02480	3.04e-47	163.0	COG0697@1|root,COG0697@2|Bacteria,1QQY8@1224|Proteobacteria,1RRQ6@1236|Gammaproteobacteria,1J7WK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_739301_1	246437.XP_006152920.1	3.74e-05	45.1	COG0100@1|root,KOG0408@2759|Eukaryota,3A0A4@33154|Opisthokonta,3BPCP@33208|Metazoa,3D14Y@33213|Bilateria,48A7I@7711|Chordata,492Q0@7742|Vertebrata,3JFJY@40674|Mammalia,35DSH@314146|Euarchontoglires	33208|Metazoa	J	small ribosomal subunit rRNA binding	MRPS11	GO:0000028,GO:0000313,GO:0000314,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006414,GO:0006415,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0019866,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032543,GO:0032984,GO:0032991,GO:0033554,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0042769,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0050896,GO:0051606,GO:0051716,GO:0065003,GO:0070013,GO:0070125,GO:0070126,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0098798,GO:0140053,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_739301_2	1198232.CYCME_0769	4.34e-75	229.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,4601G@72273|Thiotrichales	72273|Thiotrichales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_999176_1	1137269.AZWL01000011_gene3202	2.96e-35	134.0	COG0142@1|root,COG0761@1|root,COG0142@2|Bacteria,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB,polyprenyl_synt
k59_451285_2	29581.BW37_04898	2.73e-25	105.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,472YU@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_647844_1	215803.DB30_7727	1.83e-27	114.0	COG4191@1|root,COG4191@2|Bacteria,1MY5P@1224|Proteobacteria,42MTA@68525|delta/epsilon subdivisions,2WJ9Q@28221|Deltaproteobacteria,2YUZA@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,CHASE3,HAMP,HATPase_c,HisKA
k59_747141_1	525904.Tter_0799	1.26e-51	172.0	COG2197@1|root,COG2197@2|Bacteria,2NQFJ@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_615556_1	1496688.ER33_14790	1.19e-59	194.0	COG3900@1|root,COG3900@2|Bacteria,1G5FF@1117|Cyanobacteria	1117|Cyanobacteria	S	periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_615556_2	1038869.AXAN01000022_gene1923	4.08e-11	58.9	2ECC0@1|root,336AD@2|Bacteria,1QAJF@1224|Proteobacteria,2W4H1@28216|Betaproteobacteria,1KEMD@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_518395_1	631362.Thi970DRAFT_03247	7.28e-92	283.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_774615_1	1123008.KB905696_gene2768	8.68e-107	317.0	2DBF9@1|root,2Z8X9@2|Bacteria,4NHC2@976|Bacteroidetes,2FR37@200643|Bacteroidia,22ZEG@171551|Porphyromonadaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4434
k59_1025750_1	640081.Dsui_1581	7.94e-27	105.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VM61@28216|Betaproteobacteria,2KW2G@206389|Rhodocyclales	206389|Rhodocyclales	K	LuxR family transcriptional regulator	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1025750_2	1449065.JMLL01000011_gene2157	5.33e-08	54.3	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,43HRZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_319493_1	765914.ThisiDRAFT_0886	2.99e-24	103.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_518397_1	1122201.AUAZ01000009_gene2878	3.31e-80	266.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_60029_1	1121028.ARQE01000016_gene2619	7.25e-103	303.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2PK0U@255475|Aurantimonadaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_942878_1	1122599.AUGR01000004_gene2071	2.7e-29	112.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,1S2G5@1236|Gammaproteobacteria,1XJMZ@135619|Oceanospirillales	135619|Oceanospirillales	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_615570_1	99598.Cal7507_2523	3.2e-62	215.0	COG2374@1|root,COG2374@2|Bacteria,1GQK9@1117|Cyanobacteria,1HTQZ@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF3616)	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	-
k59_280589_1	76114.ebA5987	4.62e-62	199.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,2KU95@206389|Rhodocyclales	206389|Rhodocyclales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_354276_1	196367.JNFG01000037_gene7589	1.77e-20	92.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2VMXT@28216|Betaproteobacteria,1K33I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	paraquat-inducible protein A	pqiA	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_354276_2	395019.Bmul_2673	8.17e-13	67.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2VMXT@28216|Betaproteobacteria,1K33I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	paraquat-inducible protein A	pqiA	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_747161_1	755732.Fluta_0604	1.08e-09	60.1	COG1357@1|root,COG3291@1|root,COG3405@1|root,COG4412@1|root,COG1357@2|Bacteria,COG3291@2|Bacteria,COG3405@2|Bacteria,COG4412@2|Bacteria,4NMVW@976|Bacteroidetes,1I1JQ@117743|Flavobacteriia,2PBI2@246874|Cryomorphaceae	976|Bacteroidetes	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
k59_252104_1	998088.B565_2545	7.88e-96	283.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1Y3PJ@135624|Aeromonadales	135624|Aeromonadales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_385759_1	1288494.EBAPG3_25670	3.24e-49	167.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,372PB@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_385759_2	279714.FuraDRAFT_0789	6.42e-05	43.5	COG2944@1|root,COG2944@2|Bacteria,1N48U@1224|Proteobacteria,2VUHQ@28216|Betaproteobacteria,2KRAK@206351|Neisseriales	206351|Neisseriales	K	transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
k59_280592_1	1313172.YM304_07050	1.29e-44	157.0	COG3608@1|root,COG3608@2|Bacteria,2HGZV@201174|Actinobacteria,4CP02@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_715465_3	378806.STAUR_1477	5.03e-23	100.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YWK2@29|Myxococcales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_60788_1	93220.LV28_07575	1.52e-66	213.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,1K1XI@119060|Burkholderiaceae	28216|Betaproteobacteria	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_223930_1	292415.Tbd_1991	5e-175	504.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,1KRB2@119069|Hydrogenophilales	119069|Hydrogenophilales	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_682750_1	187272.Mlg_0343	2.28e-105	315.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX16@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_452053_1	1000565.METUNv1_02080	3.1e-06	49.7	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2VH76@28216|Betaproteobacteria,2KUJE@206389|Rhodocyclales	206389|Rhodocyclales	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_452053_2	580332.Slit_2856	6.47e-167	478.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,44VMS@713636|Nitrosomonadales	28216|Betaproteobacteria	I	PFAM Carbamoyl-phosphate synthase L chain ATP-binding	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_775359_1	1408224.SAMCCGM7_c5591	2.36e-62	215.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,DZR,Guanylate_cyc,TPR_12
k59_616350_1	1266925.JHVX01000003_gene406	6.56e-15	68.2	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2VSJ0@28216|Betaproteobacteria,373BC@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
k59_976479_1	215803.DB30_0647	1.17e-116	370.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_794024_1	945713.IALB_1313	9.88e-16	82.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
k59_538432_1	864051.BurJ1DRAFT_3753	1.9e-104	327.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1KJS6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_519201_1	713586.KB900536_gene3055	3.7e-91	281.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_747998_1	933262.AXAM01000033_gene1642	1.41e-108	333.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_320245_1	595460.RRSWK_02125	1.22e-11	70.1	COG1357@1|root,COG1511@1|root,COG2931@1|root,COG3291@1|root,COG1357@2|Bacteria,COG1511@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,2IZ0P@203682|Planctomycetes	203682|Planctomycetes	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Laminin_G_3
k59_519211_1	1198232.CYCME_2072	4.48e-42	139.0	2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,1S9N4@1236|Gammaproteobacteria,4630G@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_29202_1	247490.KSU1_C1256	5.95e-63	205.0	COG0579@1|root,COG0579@2|Bacteria,2IX3W@203682|Planctomycetes	203682|Planctomycetes	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
k59_584676_1	323848.Nmul_A2083	1.54e-95	295.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,3724J@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_252839_1	1049564.TevJSym_aq00670	1.17e-76	233.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1J4WI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_252839_2	519989.ECTPHS_08988	4.11e-10	59.7	COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1WW5Q@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_60828_1	717785.HYPMC_4102	1.18e-30	126.0	COG0457@1|root,COG0500@1|root,COG0457@2|Bacteria,COG0500@2|Bacteria,1QZ3F@1224|Proteobacteria,2TY48@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31,TPR_16,TPR_2,TPR_8
k59_748015_1	1291743.LOSG293_190110	5.33e-10	59.3	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,4HHF8@91061|Bacilli,3F67J@33958|Lactobacillaceae	91061|Bacilli	P	Belongs to the Fur family	perR	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1007203_1	1131553.JIBI01000039_gene1939	5.22e-76	234.0	COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,2WGC1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1007203_2	297246.lpp2332	2.4e-21	85.9	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,1SA80@1236|Gammaproteobacteria,1JEPA@118969|Legionellales	118969|Legionellales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_452091_1	439235.Dalk_2366	9.25e-63	196.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2MHUF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_452091_2	857293.CAAU_1601	1.33e-17	76.6	COG2033@1|root,COG2033@2|Bacteria,1VA34@1239|Firmicutes,24J9I@186801|Clostridia,36JYV@31979|Clostridiaceae	186801|Clostridia	C	Desulfoferrodoxin ferrous iron-binding	dfx	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016721,GO:0019430,GO:0022900,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
k59_908515_1	1265505.ATUG01000003_gene468	1.51e-77	252.0	COG2885@1|root,COG3267@1|root,COG2885@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42PJ3@68525|delta/epsilon subdivisions,2WJF6@28221|Deltaproteobacteria,2MJ4S@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,OmpA
k59_519238_1	1123354.AUDR01000016_gene1263	9.67e-06	48.5	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,1KRQH@119069|Hydrogenophilales	119069|Hydrogenophilales	I	Glycerol-3-phosphate acyltransferase	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_519238_2	1007105.PT7_0967	5.96e-32	121.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2VHDR@28216|Betaproteobacteria,3T1W3@506|Alcaligenaceae	28216|Betaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_584690_2	614083.AWQR01000007_gene424	1.32e-62	195.0	COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2VT72@28216|Betaproteobacteria,4AED9@80864|Comamonadaceae	28216|Betaproteobacteria	S	transporter component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_584690_3	748280.NH8B_3884	3.77e-24	94.7	COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,2KRR7@206351|Neisseriales	206351|Neisseriales	S	transporter component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_29224_1	1121933.AUHH01000041_gene3520	1.3e-08	55.8	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4DNE1@85009|Propionibacteriales	201174|Actinobacteria	T	response regulator	tcrX	GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0098771	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_29224_2	926569.ANT_13950	1.29e-07	55.8	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GGDEF,PAS,PilZ
k59_94927_1	1205680.CAKO01000010_gene3898	1.18e-49	171.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,2JR5U@204441|Rhodospirillales	204441|Rhodospirillales	E	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_252855_1	331869.BAL199_22132	4.59e-23	97.4	COG4857@1|root,COG4857@2|Bacteria,1MXBW@1224|Proteobacteria,2TR0Z@28211|Alphaproteobacteria,4BRV5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_252855_2	339670.Bamb_2616	5.35e-85	258.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2VIXW@28216|Betaproteobacteria,1JZMU@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Hemerythrin,PNP_phzG_C,Putative_PNPOx
k59_252855_3	1144275.COCOR_01542	1.42e-17	77.0	COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,430NN@68525|delta/epsilon subdivisions,2WVYS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
k59_159487_1	648757.Rvan_0219	1.86e-51	184.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,3N6E3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_223999_1	765912.Thimo_2488	1.58e-125	399.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1WXFY@135613|Chromatiales	135613|Chromatiales	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_846214_1	697282.Mettu_3761	3.87e-29	120.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1S48Z@1236|Gammaproteobacteria,1XEJQ@135618|Methylococcales	135618|Methylococcales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_943755_1	264198.Reut_B4415	8.87e-92	280.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VNG1@28216|Betaproteobacteria,1KH5I@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_748045_1	631454.N177_1710	1.05e-35	130.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,1JQNE@119043|Rhodobiaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	MA20_16780	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1007229_1	999611.KI421504_gene2635	2.29e-91	272.0	COG3316@1|root,COG3316@2|Bacteria,1PIDT@1224|Proteobacteria,2VAJV@28211|Alphaproteobacteria,282EB@191028|Leisingera	28211|Alphaproteobacteria	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
k59_877046_1	760117.JN27_14715	3.81e-114	335.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,472CI@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_808760_1	864051.BurJ1DRAFT_0640	3.82e-28	112.0	COG0596@1|root,COG0596@2|Bacteria,1R3U1@1224|Proteobacteria,2VNZR@28216|Betaproteobacteria,1KKK6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_1039012_1	1121878.AUGL01000007_gene1127	2.01e-78	256.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1039054_1	1129794.C427_0716	1.2e-34	130.0	2E3UE@1|root,32YRS@2|Bacteria,1N75A@1224|Proteobacteria,1S9W5@1236|Gammaproteobacteria,468Q7@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2799)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2799
k59_808865_1	580332.Slit_0650	2.66e-137	399.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,44V8Z@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1039160_1	85643.Tmz1t_2465	9.79e-23	94.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,2KU7T@206389|Rhodocyclales	206389|Rhodocyclales	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1039160_2	349521.HCH_06645	1.1e-29	119.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria,1XJ5D@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1039191_1	1114964.L485_18385	7.37e-49	160.0	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2UAE0@28211|Alphaproteobacteria,2K6GM@204457|Sphingomonadales	204457|Sphingomonadales	L	COG3293 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_808990_1	1449076.JOOE01000003_gene3278	2.54e-80	255.0	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,2TVB3@28211|Alphaproteobacteria,2K4BS@204457|Sphingomonadales	204457|Sphingomonadales	S	Phage tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_809013_1	436308.Nmar_0206	8.35e-123	369.0	COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18593	ko00720,ko01120,map00720,map01120	-	R10758	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_293990_1	153948.NAL212_0414	9.83e-37	148.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,372P0@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Response regulator receiver	pilL	-	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_751092_1	234267.Acid_0827	1.78e-53	176.0	COG1108@1|root,COG1108@2|Bacteria,3Y93X@57723|Acidobacteria	57723|Acidobacteria	P	ABC 3 transport family	-	-	-	ko:K02075	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
k59_424604_1	926569.ANT_31250	6.87e-76	257.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_457255_1	1123393.KB891326_gene110	1.5e-115	345.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI5E@28216|Betaproteobacteria,1KRNF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	nitrite transporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_261364_1	1121451.DESAM_23070	1.05e-88	281.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WKC0@28221|Deltaproteobacteria,2M7TX@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K10819	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HisKA,PAS_8,PAS_9,sCache_3_2
k59_947045_1	945713.IALB_2978	3.38e-89	285.0	COG2609@1|root,COG2609@2|Bacteria	2|Bacteria	C	pyruvate dehydrogenase (acetyl-transferring) activity	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_177_2	330214.NIDE3736	9.45e-84	261.0	COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae	2|Bacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046820,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_32812_1	572547.Amico_1691	4.56e-70	223.0	COG1638@1|root,COG1638@2|Bacteria,3TAKA@508458|Synergistetes	508458|Synergistetes	G	extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_228722_1	1142511.WIGMOR_0330	1.02e-16	81.6	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CH	hydroxylase	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008681,GO:0009058,GO:0009108,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185,ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R04989,R08768,R08773	RC00046,RC02670	ko00000,ko00001,ko00002,ko01000	-	-	iB21_1397.B21_02702,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECD_1391.ECD_02739,iEcHS_1320.EcHS_A3066	FAD_binding_3
k59_914416_2	945713.IALB_0238	2.94e-53	168.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
k59_914416_3	945713.IALB_0239	5.22e-12	62.8	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_489964_1	1205680.CAKO01000026_gene4597	8.35e-08	52.8	COG2128@1|root,COG2128@2|Bacteria,1RC52@1224|Proteobacteria,2U3FR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_489964_2	484019.THA_1947	1.39e-12	67.0	COG2039@1|root,COG2039@2|Bacteria,2GCYM@200918|Thermotogae	200918|Thermotogae	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	-	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
k59_783710_1	383381.EH30_15680	7.1e-16	74.3	COG0346@1|root,COG0346@2|Bacteria,1RKHN@1224|Proteobacteria,2UBJ1@28211|Alphaproteobacteria,2K57E@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
k59_783710_2	72019.SARC_01339T0	4.22e-24	102.0	COG2130@1|root,KOG1196@2759|Eukaryota,39AU4@33154|Opisthokonta	33154|Opisthokonta	L	2-alkenal reductase [NAD(P)] activity	QOR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
k59_163434_1	1463885.KL578401_gene7402	6.8e-81	254.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_32831_1	1268622.AVS7_01072	1.12e-109	327.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VJTU@28216|Betaproteobacteria,4AAYT@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_653232_1	94624.Bpet3827	2.4e-94	305.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,3T1DU@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_130779_1	522772.Dacet_1955	2.14e-33	121.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	COQ7,Rubrerythrin
k59_215_1	1288494.EBAPG3_11620	3.04e-125	367.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,37280@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_489982_1	62928.azo1512	2.35e-53	188.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,2KVQM@206389|Rhodocyclales	206389|Rhodocyclales	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_391999_1	330214.NIDE2255	4.97e-81	248.0	COG0412@1|root,COG0412@2|Bacteria,3J1B9@40117|Nitrospirae	40117|Nitrospirae	Q	Alpha/beta hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_424652_2	1472716.KBK24_0104725	1.61e-26	108.0	COG4566@1|root,COG4566@2|Bacteria,1QVXM@1224|Proteobacteria,2WGZZ@28216|Betaproteobacteria,1KIFU@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_522625_1	1008459.TASI_1559	9.85e-63	217.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,3T1ZH@506|Alcaligenaceae	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_685882_1	1232437.KL662032_gene2512	7.12e-17	77.0	COG0454@1|root,COG0456@2|Bacteria,1N5FD@1224|Proteobacteria,42U24@68525|delta/epsilon subdivisions,2WQXQ@28221|Deltaproteobacteria,2MKQW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_685882_2	56780.SYN_01664	1.39e-29	115.0	COG4656@1|root,COG4656@2|Bacteria,1PJE1@1224|Proteobacteria,42P69@68525|delta/epsilon subdivisions,2WIM9@28221|Deltaproteobacteria,2MR52@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_979744_1	1123367.C666_06405	2.18e-70	239.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KUBP@206389|Rhodocyclales	206389|Rhodocyclales	KNT	COG0643 Chemotaxis protein histidine kinase and related kinases	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
k59_424664_2	1288494.EBAPG3_14260	8.89e-29	110.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,371PT@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_849134_1	568706.BN118_3255	4.28e-91	277.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,3T22X@506|Alcaligenaceae	28216|Betaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_457314_1	391595.RLO149_c037000	1.04e-32	126.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_261437_1	1218076.BAYB01000049_gene5928	2.77e-37	139.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2VMM0@28216|Betaproteobacteria,1K18N@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_522643_1	414684.RC1_2513	2.54e-61	201.0	COG2204@1|root,COG2204@2|Bacteria,1MWW5@1224|Proteobacteria,2TXAZ@28211|Alphaproteobacteria,2JQAG@204441|Rhodospirillales	204441|Rhodospirillales	K	Sigma-54 interaction domain	-	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Sigma54_activat
k59_979751_1	762376.AXYL_04320	1.48e-29	120.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJ1B@28216|Betaproteobacteria	28216|Betaproteobacteria	M	RND efflux system, outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_326738_1	316274.Haur_0564	1.74e-23	102.0	COG4373@1|root,COG4373@2|Bacteria	2|Bacteria	-	-	gp17a	-	-	ko:K06909	-	-	-	-	ko00000	-	-	-	Terminase_6,Terminase_6C
k59_979753_1	1220714.L7TRU8_9CAUD	2.2e-54	184.0	4QCFY@10239|Viruses,4QVSM@35237|dsDNA viruses  no RNA stage,4QPPM@28883|Caudovirales,4QJW8@10662|Myoviridae	10662|Myoviridae	S	Uncharacterized protein conserved in bacteria (DUF2184)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_457324_1	864051.BurJ1DRAFT_2793	2.9e-28	107.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2VK3P@28216|Betaproteobacteria,1KK23@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	UPF0114 protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
k59_457324_2	1163617.SCD_n01957	6.31e-05	45.8	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_849144_1	1232410.KI421415_gene3008	1.9e-73	231.0	COG4122@1|root,COG4122@2|Bacteria,1QWN3@1224|Proteobacteria,43DC9@68525|delta/epsilon subdivisions,2X8IA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
k59_326746_1	999141.GME_03392	7.88e-119	352.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1XH80@135619|Oceanospirillales	135619|Oceanospirillales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_685904_2	864051.BurJ1DRAFT_0241	1.1e-60	192.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,1KKK8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	JM	Nucleotidyl transferase	rmlA	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_392036_1	1304877.KI519401_gene44	7.53e-101	302.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,3JT6Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	hmm pf01609	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DUF772
k59_130815_1	397945.Aave_2024	3.01e-227	644.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2W14D@28216|Betaproteobacteria,4AJPK@80864|Comamonadaceae	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_163491_1	1279017.AQYJ01000026_gene282	1.23e-104	320.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,465YM@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_522654_1	1415780.JPOG01000001_gene1056	3.85e-70	232.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1X37B@135614|Xanthomonadales	1236|Gammaproteobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_359368_1	637905.SVI_3141	2.27e-32	122.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,2Q9VE@267890|Shewanellaceae	1236|Gammaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_359368_2	674977.VMC_26410	5.9e-11	63.2	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1XSXA@135623|Vibrionales	135623|Vibrionales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_359371_1	1079986.JH164851_gene1138	3.85e-45	166.0	COG0480@1|root,COG0480@2|Bacteria,2GJ64@201174|Actinobacteria	201174|Actinobacteria	J	elongation factor G	tetM	-	-	ko:K18220	-	-	-	-	br01600,ko00000,ko01504	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_457336_1	631362.Thi970DRAFT_02935	9.51e-85	261.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,1RPII@1236|Gammaproteobacteria,1WVYZ@135613|Chromatiales	135613|Chromatiales	G	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_587983_2	795666.MW7_3398	2.13e-102	301.0	COG1838@1|root,COG1838@2|Bacteria,1MVNG@1224|Proteobacteria,2VMDH@28216|Betaproteobacteria,1K6CN@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Fumarase C-terminus	-	-	4.2.1.2,4.2.1.32	ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
k59_947140_1	1123354.AUDR01000012_gene1938	7.75e-10	58.9	2EDY7@1|root,337T3@2|Bacteria,1RKSZ@1224|Proteobacteria,2VTSJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_947140_2	1266925.JHVX01000005_gene1848	1.26e-25	105.0	COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,3722R@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_196168_1	1187851.A33M_0952	3.71e-73	232.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
k59_196168_2	1038858.AXBA01000028_gene1008	6.91e-18	82.4	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,3F0MK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_228791_1	1041146.ATZB01000075_gene403	4.35e-91	275.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria,4BF2S@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
k59_751178_1	1121403.AUCV01000040_gene4322	2.04e-96	292.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42QB5@68525|delta/epsilon subdivisions,2WMMA@28221|Deltaproteobacteria,2MQ1A@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_228795_1	390235.PputW619_1360	6.66e-47	164.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1YXEZ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_228795_2	396588.Tgr7_1275	0.000711	41.2	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1WWD8@135613|Chromatiales	135613|Chromatiales	O	Belongs to the HypD family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_653317_1	279238.Saro_0473	1.33e-07	58.2	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,2K1HK@204457|Sphingomonadales	204457|Sphingomonadales	FP	exopolyphosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_326780_1	385682.AFSL01000072_gene1327	7.29e-76	240.0	COG1593@1|root,COG1593@2|Bacteria,4NE5T@976|Bacteroidetes,2FR36@200643|Bacteroidia,3XJA0@558415|Marinilabiliaceae	976|Bacteroidetes	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_849173_1	637390.AFOH01000050_gene1721	2.43e-33	124.0	COG0561@1|root,COG0561@2|Bacteria,1QDJR@1224|Proteobacteria,1RSEI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	S6PP,YcgL
k59_849173_2	323261.Noc_3070	3e-23	96.3	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1WXVN@135613|Chromatiales	135613|Chromatiales	G	PfkB domain protein	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_294114_1	95619.PM1_0211675	1.95e-78	258.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Dehydrogenase E1 component	sucA	GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_685936_1	622637.KE124774_gene3888	2.25e-115	339.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,36Z6K@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_979791_1	911045.PSE_p0146	3.76e-28	116.0	COG3385@1|root,COG3385@2|Bacteria,1RCTP@1224|Proteobacteria,2UPV7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_130858_1	395494.Galf_0583	2.5e-93	277.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,44VAX@713636|Nitrosomonadales	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_392072_1	1349767.GJA_2697	8.15e-05	50.1	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VM3A@28216|Betaproteobacteria,476MG@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
k59_555376_1	330214.NIDE3615	2.66e-128	379.0	COG2081@1|root,COG2081@2|Bacteria,3J12U@40117|Nitrospirae	40117|Nitrospirae	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
k59_751195_1	1207063.P24_03830	3.01e-74	248.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JP8A@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_685943_1	977880.RALTA_A1914	7.76e-12	65.1	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,1K14R@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the BI1 family	yccA	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
k59_685943_2	393595.ABO_0248	3.92e-19	89.4	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1XJQS@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
k59_32933_1	748247.AZKH_0078	8.54e-21	92.4	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,2KVUV@206389|Rhodocyclales	206389|Rhodocyclales	C	formate dehydrogenase	fdhC	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_947178_1	1485544.JQKP01000002_gene1562	1.64e-54	187.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,44VJY@713636|Nitrosomonadales	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_490083_1	945713.IALB_1883	3.14e-61	206.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
k59_163556_1	1042377.AFPJ01000035_gene2629	1.44e-54	186.0	28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria,4662R@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_33390_1	1121481.AUAS01000001_gene4691	1.1e-13	76.6	COG3391@1|root,COG3391@2|Bacteria,4PKC0@976|Bacteroidetes,47Y3T@768503|Cytophagia	976|Bacteroidetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_759553_1	1229909.NSED_07280	5.24e-90	268.0	COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Proteasome endopeptidase complex	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
k59_465749_1	305900.GV64_09075	2.66e-20	96.7	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RPBD@1236|Gammaproteobacteria,1XI79@135619|Oceanospirillales	135619|Oceanospirillales	E	Peptidase M19	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
k59_369356_1	1294143.H681_06540	6.92e-153	440.0	28IWG@1|root,2Z8US@2|Bacteria,1NHDW@1224|Proteobacteria,1RR5V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
k59_337041_1	1216976.AX27061_2264	1.51e-68	221.0	COG1250@1|root,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2VI1C@28216|Betaproteobacteria,3T1KH@506|Alcaligenaceae	28216|Betaproteobacteria	C	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_925095_2	330214.NIDE3299	8.95e-40	140.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 4 Homologs of previously reported genes of	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase
k59_957637_1	981383.AEWH01000071_gene1125	1.53e-16	85.5	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,1TPG1@1239|Firmicutes,4HB2J@91061|Bacilli	91061|Bacilli	C	COG0247 Fe-S oxidoreductase	ywjF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_957638_1	1206731.BAGB01000003_gene1161	1.33e-31	124.0	COG4122@1|root,COG4122@2|Bacteria,2IA2G@201174|Actinobacteria	201174|Actinobacteria	S	Macrocin-O-methyltransferase (TylF)	-	-	-	ko:K19856,ko:K21325	ko00523,ko01130,map00523,map01130	M00799	R11041,R11469	RC00003,RC00466	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_24,TylF
k59_337044_1	862965.PARA_02220	1.39e-10	62.4	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1Y7ED@135625|Pasteurellales	135625|Pasteurellales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_337044_2	930169.B5T_01844	2.59e-57	184.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,1XIB2@135619|Oceanospirillales	135619|Oceanospirillales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
k59_598373_1	243160.BMA0894	1.09e-118	358.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,1K0E9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_108685_1	395494.Galf_1553	4.9e-15	73.2	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,44VNK@713636|Nitrosomonadales	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_108685_2	999541.bgla_1g10400	3.39e-66	211.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,1K35C@119060|Burkholderiaceae	28216|Betaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645,ko:K15355	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_500741_1	159087.Daro_1198	1.5e-72	236.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,2KVS9@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type Fe3 transport system, permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_43288_1	671143.DAMO_2631	1.06e-32	129.0	COG1463@1|root,COG1463@2|Bacteria,2NPXJ@2323|unclassified Bacteria	2|Bacteria	Q	MlaD protein	ttg2C	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_76325_1	1288494.EBAPG3_18770	2.53e-97	292.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,372TZ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_957640_1	381666.PHG417	6.32e-12	64.7	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,1KBMI@119060|Burkholderiaceae	28216|Betaproteobacteria	F	phosphoglycerate kinase activity	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_957640_2	395494.Galf_0031	3.37e-153	445.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,44VCT@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pykA	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_500749_1	326424.FRAAL1238	4.86e-64	211.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4EUCZ@85013|Frankiales	201174|Actinobacteria	GM	ABC transporter	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
k59_663957_1	999411.HMPREF1092_02419	7.45e-30	109.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,36E4K@31979|Clostridiaceae	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_663957_2	552396.HMPREF0863_02786	7.77e-10	56.6	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,3VRP2@526524|Erysipelotrichia	526524|Erysipelotrichia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_663957_3	945713.IALB_0921	1.46e-21	85.5	COG0186@1|root,COG0186@2|Bacteria	2|Bacteria	J	rRNA binding	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_529428_1	666684.AfiDRAFT_3139	5.46e-09	61.2	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JXFS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_529428_2	631454.N177_1007	4.15e-18	88.6	COG3181@1|root,COG3181@2|Bacteria,1PGFA@1224|Proteobacteria,2V8Q5@28211|Alphaproteobacteria,1JQCI@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_663969_1	1278073.MYSTI_01205	4.33e-49	160.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,4331F@68525|delta/epsilon subdivisions,2WXKR@28221|Deltaproteobacteria,2YY54@29|Myxococcales	28221|Deltaproteobacteria	C	SUF system FeS assembly protein	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_957666_1	1071679.BG57_03030	5.46e-41	154.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIHF@28216|Betaproteobacteria,1K3GQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Penicillin amidase	-	-	3.5.1.97	ko:K07116	-	-	-	-	ko00000,ko01000	-	-	-	Penicil_amidase
k59_663976_1	1122139.KB907884_gene404	2.59e-11	64.3	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1XJPG@135619|Oceanospirillales	135619|Oceanospirillales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_10966_1	1157708.KB907452_gene4040	9.79e-14	72.4	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VHIY@28216|Betaproteobacteria,4AJUQ@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD TfdA	tauD	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_10966_2	543728.Vapar_6115	2.77e-92	284.0	COG3181@1|root,COG3181@2|Bacteria,1NBZ9@1224|Proteobacteria,2VH6P@28216|Betaproteobacteria,4ADAM@80864|Comamonadaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_859155_1	1380394.JADL01000001_gene2482	2.13e-160	462.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_43331_1	1121396.KB892979_gene1702	2.14e-33	129.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NV6@68525|delta/epsilon subdivisions,2WIPB@28221|Deltaproteobacteria,2MIMA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_141385_1	1131553.JIBI01000007_gene1191	0.000169	43.9	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,372H6@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_141385_2	977880.RALTA_A1041	1.8e-61	200.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,1K1ZY@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_957684_1	436308.Nmar_1698	6.01e-124	368.0	COG0004@1|root,arCOG04397@2157|Archaea,41SY0@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_174034_1	404589.Anae109_0670	4.62e-23	102.0	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,42PS3@68525|delta/epsilon subdivisions,2X7MQ@28221|Deltaproteobacteria,2YVCB@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_8
k59_369414_1	1121952.ATXT01000003_gene2529	6.13e-67	211.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4FKZX@85023|Microbacteriaceae	201174|Actinobacteria	Q	Domain of unknown function (DUF2437)	fahA	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_400644_1	671143.DAMO_2717	2.97e-62	218.0	COG1452@1|root,COG1452@2|Bacteria,2NPN2@2323|unclassified Bacteria	2|Bacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659	-	ko:K04744,ko:K09774,ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2,1.B.42.1	-	iAF987.Gmet_2474,iECO111_1330.ECO111_4695,iECSF_1327.ECSF_3725,iEcSMS35_1347.EcSMS35_4260	KdgM,OstA,OstA_2,OstA_C
k59_337113_1	436308.Nmar_1690	9.64e-24	99.0	COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_337113_2	1229909.NSED_08995	3.32e-69	213.0	COG1394@1|root,arCOG04101@2157|Archaea,41T0N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_1017137_1	1266925.JHVX01000001_gene2629	2.52e-60	209.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	AMP-dependent synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_76387_1	1168067.JAGP01000001_gene1246	5.63e-10	63.5	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_76387_2	1123393.KB891328_gene592	2.34e-15	77.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VNYV@28216|Betaproteobacteria,1KS6P@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_598444_1	1229172.JQFA01000002_gene3304	6.77e-88	264.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1H7AV@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
k59_465815_1	1077972.ARGLB_037_01740	2.63e-55	186.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,1WAEE@1268|Micrococcaceae	201174|Actinobacteria	E	TOBE domain	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_108761_1	1288494.EBAPG3_13360	1.08e-81	260.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,372U6@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Orn/Lys/Arg decarboxylase, C-terminal domain	-	-	4.1.1.19	ko:K01583	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
k59_827310_1	1047013.AQSP01000128_gene455	1.73e-25	109.0	COG0018@1|root,COG0018@2|Bacteria,2NNSE@2323|unclassified Bacteria	2|Bacteria	J	Arginyl tRNA synthetase N terminal dom	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_859196_1	748658.KB907314_gene142	3.37e-66	202.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,1X16T@135613|Chromatiales	135613|Chromatiales	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
k59_696791_1	1121434.AULY01000006_gene929	1.31e-61	210.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_827319_1	1265502.KB905930_gene1490	1.08e-104	315.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,4ABMU@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_174069_1	330214.NIDE0344	8.41e-36	131.0	COG0714@1|root,COG0714@2|Bacteria,3J0WQ@40117|Nitrospirae	40117|Nitrospirae	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_337149_1	765912.Thimo_0927	1.62e-19	85.9	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1WX3Q@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	cysB	-	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_337149_2	477184.KYC_23768	2.59e-64	212.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,3T1UQ@506|Alcaligenaceae	28216|Betaproteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	-	1.8.1.2,1.8.7.1	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858,R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_957745_1	273068.TTE2389	2.86e-27	110.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_174081_1	228410.NE2342	2.16e-57	190.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,2VIZ8@28216|Betaproteobacteria,372AT@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_76424_1	1121405.dsmv_1455	6.12e-54	188.0	COG1208@1|root,COG3178@1|root,COG1208@2|Bacteria,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,42N6V@68525|delta/epsilon subdivisions,2WIQC@28221|Deltaproteobacteria,2MI45@213118|Desulfobacterales	28221|Deltaproteobacteria	JM	PFAM aminoglycoside phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH,NTP_transferase
k59_891421_1	582899.Hden_2640	3.42e-15	70.5	COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria,3N7B0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0335 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2312
k59_337158_1	1198452.Jab_1c17060	2.33e-67	228.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,473XY@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Belongs to the peptidase M16 family	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_729291_1	1121943.KB900008_gene1991	6.72e-07	56.6	COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1R97W@1224|Proteobacteria	1224|Proteobacteria	D	Phage-related minor tail protein	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_566054_2	330214.NIDE2542	3.55e-143	414.0	COG0505@1|root,COG0505@2|Bacteria,3J0CS@40117|Nitrospirae	40117|Nitrospirae	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_108809_1	1231391.AMZF01000014_gene2317	1.62e-50	172.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria	1224|Proteobacteria	S	TRAP transporter, solute receptor (TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_529497_1	557599.MKAN_25890	2.22e-25	108.0	COG1073@1|root,COG1073@2|Bacteria,2I8SP@201174|Actinobacteria,234F7@1762|Mycobacteriaceae	201174|Actinobacteria	S	alpha beta	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	-
k59_529497_2	504832.OCAR_7706	4.16e-07	51.2	COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,2TTFI@28211|Alphaproteobacteria,3JW4B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp,EamA
k59_206447_1	1123252.ATZF01000020_gene2928	5.26e-05	44.3	COG2608@1|root,COG2608@2|Bacteria,1VK5F@1239|Firmicutes,4IRA4@91061|Bacilli,27DB9@186824|Thermoactinomycetaceae	91061|Bacilli	P	Heavy-metal-associated domain	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
k59_206447_2	1191523.MROS_0327	6.53e-15	76.3	COG2217@1|root,COG2217@2|Bacteria	2|Bacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_141475_1	640081.Dsui_1584	4.6e-62	198.0	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2VJCF@28216|Betaproteobacteria,2KWJC@206389|Rhodocyclales	206389|Rhodocyclales	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
k59_43433_1	1297863.APJF01000023_gene3592	6.83e-45	150.0	COG3193@1|root,COG3193@2|Bacteria,1REF5@1224|Proteobacteria,2U5M2@28211|Alphaproteobacteria,3JYF2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_238142_1	880073.Calab_3765	5.68e-36	133.0	COG3104@1|root,COG3104@2|Bacteria,2NQCQ@2323|unclassified Bacteria	2|Bacteria	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_566941_1	945713.IALB_0313	3.2e-61	199.0	2CD20@1|root,2Z7SQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_566941_2	945713.IALB_0314	6.71e-35	125.0	COG0179@1|root,COG0179@2|Bacteria	2|Bacteria	Q	Fumarylacetoacetate (FAA) hydrolase	ycgM	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_787354_1	1288494.EBAPG3_7750	1.61e-78	259.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,371VQ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_338036_1	1165096.ARWF01000001_gene977	1.06e-18	82.8	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2VKKJ@28216|Betaproteobacteria,2KKY6@206350|Nitrosomonadales	206350|Nitrosomonadales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_338036_2	1131553.JIBI01000017_gene580	1.28e-70	222.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,37239@32003|Nitrosomonadales	28216|Betaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_338036_3	292415.Tbd_0387	3.03e-82	252.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,1KRHN@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_501816_1	76114.ebA4100	4.9e-66	216.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,2KV14@206389|Rhodocyclales	206389|Rhodocyclales	M	Membrane-bound lytic murein transglycosylase	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
k59_926173_1	153948.NAL212_1559	1.97e-30	114.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,3729C@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
k59_926173_2	626887.J057_01449	9.02e-26	103.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,466DX@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECO111_1330.ECO111_2936,iYL1228.KPN_02080	CcmB
k59_760364_2	29581.BW37_00518	2.15e-39	135.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,474F2@75682|Oxalobacteraceae	28216|Betaproteobacteria	KT	cheY-homologous receiver domain	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_736290_2	335543.Sfum_3937	1.05e-16	78.2	2D2K4@1|root,32TD0@2|Bacteria,1MZKF@1224|Proteobacteria,42TFV@68525|delta/epsilon subdivisions,2WQ7B@28221|Deltaproteobacteria,2MRY5@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3124
k59_507672_1	323848.Nmul_A1088	2.55e-30	113.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,372RB@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_507672_2	1458357.BG58_30765	4.11e-32	120.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,1K1YY@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_471448_1	290512.Paes_0783	7.24e-16	82.8	COG1376@1|root,COG2304@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG4932@1|root,COG5295@1|root,COG1376@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,COG5295@2|Bacteria,1FETB@1090|Chlorobi	1090|Chlorobi	QUW	outer membrane adhesin like proteiin	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_50073_1	1232410.KI421425_gene1569	2.86e-52	177.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WPA2@28221|Deltaproteobacteria,43TZT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome b(C-terminal)/b6/petD	cbcW	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrom_C,Cytochrome_B,Cytochrome_CBB3
k59_834413_2	1410622.JNKY01000019_gene1792	3.48e-39	139.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,27JS3@186928|unclassified Lachnospiraceae	186801|Clostridia	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_605195_1	358681.BBR47_31950	8.79e-10	61.2	COG1020@1|root,COG1028@1|root,COG3321@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Aminotran_3,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt
k59_605195_2	1121101.HMPREF1532_01743	1.36e-14	74.7	COG1560@1|root,COG1560@2|Bacteria,4NGQU@976|Bacteroidetes,2FPU3@200643|Bacteroidia,4AMRC@815|Bacteroidaceae	976|Bacteroidetes	M	Lipid A biosynthesis (KDO)2-(Lauroyl)-lipid IVA acyltransferase	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_637570_2	153948.NAL212_2483	1.89e-58	194.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,371UP@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidase family M23	-	-	3.4.24.75	ko:K08259	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_17921_1	1125863.JAFN01000001_gene1444	4.57e-97	295.0	COG0577@1|root,COG0577@2|Bacteria,1R6DP@1224|Proteobacteria,42PWX@68525|delta/epsilon subdivisions,2WJSB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_441261_1	314285.KT71_01925	2.15e-78	239.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1J998@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	SelR domain	-	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR,TAT_signal
k59_441261_2	335283.Neut_0489	1.61e-06	48.9	COG2261@1|root,COG2261@2|Bacteria,1PI3R@1224|Proteobacteria,2W6PA@28216|Betaproteobacteria,374EV@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_406332_1	2754.EH55_11975	3.46e-29	120.0	COG2801@1|root,COG2801@2|Bacteria,3TAWD@508458|Synergistetes	508458|Synergistetes	L	SPTR Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,rve
k59_605198_1	300852.55771566	3.32e-19	91.7	COG0508@1|root,COG0508@2|Bacteria,1WI1G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_310063_1	1123376.AUIU01000011_gene1029	3.23e-16	74.3	COG2952@1|root,COG2952@2|Bacteria,3J1ED@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF507)	-	-	-	-	-	-	-	-	-	-	-	-	DUF507
k59_310063_2	330214.NIDE1594	7.38e-11	58.5	COG2952@1|root,COG2952@2|Bacteria,3J1DP@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF507)	-	-	-	-	-	-	-	-	-	-	-	-	DUF507
k59_765341_1	640081.Dsui_1266	7.54e-60	188.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2VR9P@28216|Betaproteobacteria,2KWBU@206389|Rhodocyclales	206389|Rhodocyclales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_441263_1	29306.JOBE01000104_gene3637	2.24e-10	63.9	COG2197@1|root,COG2197@2|Bacteria,2GN80@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_865935_1	232721.Ajs_4040	8.96e-34	124.0	COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,2VVSJ@28216|Betaproteobacteria,4AF3V@80864|Comamonadaceae	28216|Betaproteobacteria	NU	Belongs to the N-Me-Phe pilin family	pilA	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
k59_343900_1	58123.JOFJ01000005_gene1426	0.000103	48.5	2DMT0@1|root,32TGD@2|Bacteria	2|Bacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT,bPH_3
k59_637576_1	266834.SM_b20806	2.71e-48	161.0	COG1442@1|root,COG1442@2|Bacteria,1QH4S@1224|Proteobacteria,2U9KQ@28211|Alphaproteobacteria,4B9U9@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_834428_1	1185766.DL1_05740	1.73e-23	100.0	COG0457@1|root,COG0457@2|Bacteria,1N0DE@1224|Proteobacteria,2UCGA@28211|Alphaproteobacteria,2XMTY@285107|Thioclava	28211|Alphaproteobacteria	S	Tetratricopeptide repeats	MA20_05980	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
k59_834428_2	4896.SPBC12C2.12c.1	0.000824	45.4	COG0346@1|root,KOG2944@2759|Eukaryota,38CS6@33154|Opisthokonta,3NVC4@4751|Fungi,3QJCR@4890|Ascomycota,3MDEM@451866|Taphrinomycotina	4751|Fungi	G	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	GLO1	GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006081,GO:0006082,GO:0006089,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009438,GO:0009628,GO:0009636,GO:0009987,GO:0016829,GO:0016846,GO:0019243,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042180,GO:0042182,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0051596,GO:0051716,GO:0061727,GO:0070887,GO:0071214,GO:0071470,GO:0071704,GO:0097237,GO:0098754,GO:0104004,GO:1901564,GO:1901575,GO:1901615,GO:1990748	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_148323_1	1306947.ARQD01000002_gene506	9.64e-70	221.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,2NPBE@2323|unclassified Bacteria	2|Bacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrB	GO:0003674,GO:0003824,GO:0008113,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016667,GO:0016671,GO:0044419,GO:0051704,GO:0055114	1.8.4.11,1.8.4.12	ko:K07304,ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_605208_2	1459636.NTE_03553	1.3e-47	164.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_572980_1	1121035.AUCH01000004_gene429	3.44e-72	244.0	COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria	1224|Proteobacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
k59_343911_2	1267535.KB906767_gene820	7.01e-80	246.0	COG0214@1|root,COG0214@2|Bacteria,3Y3ST@57723|Acidobacteria,2JKN5@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
k59_50103_1	670307.HYPDE_41603	4.03e-102	317.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,3N6CB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_441280_2	1254432.SCE1572_31295	1.6e-43	145.0	COG4319@1|root,COG4319@2|Bacteria,1NKFM@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_2,SnoaL_3
k59_406349_1	391625.PPSIR1_00720	7.15e-32	131.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_834444_1	1211115.ALIQ01000045_gene2932	1.71e-73	228.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,3N9Q1@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Thioredoxin	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_148335_1	1266925.JHVX01000018_gene1825	8.44e-201	562.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,372HU@32003|Nitrosomonadales	28216|Betaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_471481_1	1458427.BAWN01000009_gene613	1.22e-06	57.4	COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,2VNH2@28216|Betaproteobacteria,4ACVV@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,MASE2
k59_703956_1	1500894.JQNN01000001_gene4456	4.15e-09	57.4	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,473ER@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	type II secretion system protein	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_703956_2	745411.B3C1_12149	1.37e-21	94.4	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1J4T3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Mg2 and Co2 transporter CorB	yfjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_441282_2	1459636.NTE_02230	1.77e-148	431.0	COG2304@1|root,arCOG02900@2157|Archaea	2157|Archaea	O	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
k59_736349_1	335543.Sfum_2387	5.93e-60	201.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,42KZU@68525|delta/epsilon subdivisions,2WJ6T@28221|Deltaproteobacteria,2MSKS@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
k59_83351_1	426114.THI_0170	1.48e-48	176.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1KK29@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_996384_1	1380356.JNIK01000019_gene212	2.75e-27	110.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria	201174|Actinobacteria	Q	N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_376033_2	365046.Rta_12760	2.69e-16	77.8	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,4AAM8@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_148356_1	545695.TREAZ_3319	1.09e-21	98.2	2CFN2@1|root,34AP1@2|Bacteria,2JA1Q@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_343938_1	292415.Tbd_1001	4.57e-89	271.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,1KRGV@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_671134_2	926569.ANT_19030	8.53e-79	239.0	COG2220@1|root,COG2220@2|Bacteria,2G6IQ@200795|Chloroflexi	200795|Chloroflexi	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_573023_1	631362.Thi970DRAFT_04763	8.51e-109	321.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RMF2@1236|Gammaproteobacteria,1X0ZR@135613|Chromatiales	135613|Chromatiales	O	HflC and HflK could regulate a protease	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_17980_2	323848.Nmul_A1542	4.81e-54	183.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VKQG@28216|Betaproteobacteria,371QI@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the glutamate synthase family	glt	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k59_442320_1	945713.IALB_0905	7.85e-108	343.0	COG0085@1|root,COG0085@2|Bacteria	2|Bacteria	K	DNA-directed 5'-3' RNA polymerase activity	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_606310_2	365046.Rta_15900	4.31e-12	65.5	COG1995@1|root,COG1995@2|Bacteria,1MXGJ@1224|Proteobacteria,2VISV@28216|Betaproteobacteria,4ABVP@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the PdxA family	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_997464_1	517418.Ctha_0779	9.02e-73	231.0	COG0827@1|root,COG0827@2|Bacteria,1FEWV@1090|Chlorobi	1090|Chlorobi	H	Eco57I restriction-modification methylase	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
k59_181892_1	713586.KB900536_gene1085	3.09e-92	285.0	COG1511@1|root,COG1511@2|Bacteria,1NYJB@1224|Proteobacteria,1S1D4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	MotA TolQ ExbB proton channel family	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_181892_2	1260251.SPISAL_00450	1.43e-05	46.6	COG1196@1|root,COG1360@1|root,COG1196@2|Bacteria,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,1RZ44@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	OmpA MotB	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
k59_311104_1	290397.Adeh_2994	1.86e-133	390.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WK79@28221|Deltaproteobacteria,2YV9G@29|Myxococcales	28221|Deltaproteobacteria	H	aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_574110_1	1042377.AFPJ01000054_gene1686	1.55e-51	182.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,469KU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1021058_2	365044.Pnap_2770	4.69e-07	53.1	COG3308@1|root,COG3308@2|Bacteria,1N1EF@1224|Proteobacteria,2VU3C@28216|Betaproteobacteria,4AECU@80864|Comamonadaceae	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2069
k59_867040_1	543728.Vapar_0490	2.67e-73	233.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria,4AAIT@80864|Comamonadaceae	28216|Betaproteobacteria	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	ybdK	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
k59_149435_1	1163617.SCD_n01924	6.17e-103	317.0	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,2VHA4@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_606324_1	929713.NIASO_04780	2.81e-62	207.0	COG0153@1|root,COG0153@2|Bacteria,4NE0C@976|Bacteroidetes,1IQPQ@117747|Sphingobacteriia	976|Bacteroidetes	G	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
k59_766329_1	323848.Nmul_A1393	1.59e-82	274.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,3727F@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_311117_1	314278.NB231_16468	3.7e-135	402.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_606325_1	1123487.KB892857_gene2507	9.82e-11	64.3	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2VK7T@28216|Betaproteobacteria,2KUKS@206389|Rhodocyclales	206389|Rhodocyclales	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase
k59_574112_1	882378.RBRH_01650	4.99e-08	58.5	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,1K1WC@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_574112_2	640081.Dsui_3403	1.6e-90	304.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KUGH@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971,DUF748
k59_407336_1	903818.KI912268_gene1968	4.2e-15	80.9	28HEE@1|root,2Z7QU@2|Bacteria	2|Bacteria	S	TIGRFAM phage plasmid-related protein TIGR03299	-	-	-	-	-	-	-	-	-	-	-	-	DUF932
k59_407336_2	1218352.B597_022185	8.56e-24	94.4	COG0758@1|root,COG0758@2|Bacteria,1R1U0@1224|Proteobacteria,1T5AZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	LU	Protein of unknown function (DUF2493)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2493
k59_442354_1	640081.Dsui_3441	2.2e-104	331.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,2KUP6@206389|Rhodocyclales	206389|Rhodocyclales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_214229_1	864051.BurJ1DRAFT_2886	1.79e-93	286.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,1KN36@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_737511_1	945713.IALB_2705	3.16e-60	199.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
k59_965959_1	859657.RPSI07_0702	4.62e-115	358.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,1K1JU@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_311135_1	640081.Dsui_0131	8.25e-93	288.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,2KV5X@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_155163_1	1279017.AQYJ01000028_gene2297	6.61e-13	75.1	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria,46AB4@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	COG2909 ATP-dependent transcriptional regulator	malT	GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030246,GO:0031323,GO:0031326,GO:0042802,GO:0044238,GO:0048031,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070492,GO:0071704,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
k59_447843_1	330214.NIDE1381	3.87e-148	426.0	COG0568@1|root,COG0568@2|Bacteria	2|Bacteria	K	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_24812_1	1260251.SPISAL_04510	1.19e-43	162.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales	135613|Chromatiales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_771510_1	1333856.L686_10460	3.4e-50	167.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S66F@1236|Gammaproteobacteria,1Z0D0@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_382352_1	671143.DAMO_2019	2.52e-07	52.4	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_971897_1	933262.AXAM01000052_gene1993	1.79e-112	330.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria,2MIFY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_971897_2	1121877.JQKF01000009_gene544	8.69e-05	42.0	COG0185@1|root,COG0185@2|Bacteria,2IKMS@201174|Actinobacteria,4CN5R@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_1023941_1	999541.bgla_1g09650	2.86e-08	52.4	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,1K7M8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_1023941_2	522306.CAP2UW1_2897	1.4e-18	80.5	COG5416@1|root,COG5416@2|Bacteria	2|Bacteria	FG	Lipopolysaccharide assembly protein A domain	lapA	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	LapA_dom
k59_122431_1	1245469.S58_00030	7.14e-70	225.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,3JUE8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_514690_1	1499967.BAYZ01000159_gene528	1.94e-30	116.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_514690_2	416591.Tlet_1122	4.83e-38	136.0	COG0411@1|root,COG0411@2|Bacteria	2|Bacteria	E	ABC transporter	MA20_16465	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_249057_1	1121035.AUCH01000003_gene1315	5.45e-134	392.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,2KUR1@206389|Rhodocyclales	206389|Rhodocyclales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_743411_1	1071679.BG57_05100	6.82e-79	252.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,1K1H9@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_792399_1	1177928.TH2_01455	5.81e-05	42.7	COG4256@1|root,COG4256@2|Bacteria,1NGJH@1224|Proteobacteria	1224|Proteobacteria	P	Hemin uptake protein	hmuP	-	-	-	-	-	-	-	-	-	-	-	hemP
k59_792399_2	983917.RGE_40790	6.14e-25	95.9	COG1918@1|root,COG1918@2|Bacteria,1NASN@1224|Proteobacteria,2VY27@28216|Betaproteobacteria,1KMU0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	FeoA	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
k59_792399_3	1123393.KB891317_gene2240	2.25e-13	68.9	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,1KSYV@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Ferrous iron transport protein B C terminus	-	-	-	-	-	-	-	-	-	-	-	-	FeoB_C,FeoB_N,Gate
k59_122446_1	1828.JOKB01000048_gene2500	5.22e-07	50.8	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,4FYD5@85025|Nocardiaceae	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_90424_1	1229909.NSED_00680	1.12e-62	201.0	COG0604@1|root,arCOG01458@2157|Archaea,41SX7@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_90424_2	436308.Nmar_1566	5.25e-51	166.0	COG1096@1|root,arCOG00676@2157|Archaea,41SQA@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	-
k59_612028_1	375286.mma_1291	9.18e-45	155.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VJTU@28216|Betaproteobacteria,477DI@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_612028_2	883080.HMPREF9697_01872	9.04e-96	288.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,3JSFG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_15895	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_249068_2	330214.NIDE4392	7.38e-26	99.8	COG4113@1|root,COG4113@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_580079_1	1367847.JCM7686_0174	6.94e-52	181.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,2PUTU@265|Paracoccus	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_678257_2	1211115.ALIQ01000196_gene65	7.81e-58	191.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria	1224|Proteobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_939259_1	1313172.YM304_32850	1.82e-127	370.0	COG0451@1|root,COG0451@2|Bacteria,2GP0W@201174|Actinobacteria	201174|Actinobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_447873_1	420324.KI911984_gene5121	3.29e-33	124.0	COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,2U1TU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_477361_1	330214.NIDE2826	3.1e-26	106.0	COG1459@1|root,COG1459@2|Bacteria,3J0HZ@40117|Nitrospirae	40117|Nitrospirae	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
k59_477361_2	326423.RBAM_019170	6.13e-05	46.2	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1TP24@1239|Firmicutes,4HA77@91061|Bacilli,1ZCHY@1386|Bacillus	91061|Bacilli	M	COG1388 FOG LysM repeat	-	-	-	ko:K19220,ko:K19223,ko:K19224	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	CBM50	-	LysM,NLPC_P60
k59_412361_1	998674.ATTE01000001_gene4139	2.11e-76	248.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,1RY3W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	transport system permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_155203_1	644282.Deba_1526	7.34e-49	163.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42SIE@68525|delta/epsilon subdivisions,2WP8B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_743432_1	945713.IALB_2083	4.2e-24	106.0	COG0728@1|root,COG0728@2|Bacteria	2|Bacteria	M	peptidoglycan biosynthetic process	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_514723_1	1304275.C41B8_03216	1.46e-47	168.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase
k59_644417_1	1168059.KB899087_gene2314	1.55e-69	229.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,3EZ3I@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	acsA1	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_644417_2	984962.XP_009552113.1	1.25e-06	48.9	COG0625@1|root,KOG0867@2759|Eukaryota,38HUQ@33154|Opisthokonta,3NX0U@4751|Fungi,3V1DM@5204|Basidiomycota,228YX@155619|Agaricomycetes,3H4RG@355688|Agaricomycetes incertae sedis	4751|Fungi	O	Glutathione S-transferase, N-terminal domain	-	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004364,GO:0004601,GO:0004602,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006801,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016740,GO:0016765,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0042221,GO:0043603,GO:0044237,GO:0044424,GO:0044464,GO:0050896,GO:0051186,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901564,GO:1901700,GO:1901701,GO:1990748	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
k59_939268_1	935548.KI912159_gene1927	6.97e-12	70.5	COG1595@1|root,COG1595@2|Bacteria,1R96P@1224|Proteobacteria,2VF9J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	SnoaL-like domain	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
k59_905245_1	330214.NIDE1707	2.19e-88	284.0	COG0013@1|root,COG0013@2|Bacteria,3J0D3@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_842664_1	1232437.KL662012_gene1428	6.51e-26	105.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2MISS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_842664_2	236097.ADG881_2038	1.65e-23	92.4	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XJH4@135619|Oceanospirillales	135619|Oceanospirillales	K	at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA)	glnK-2	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
k59_220715_1	762376.AXYL_04782	4.92e-29	118.0	COG3181@1|root,COG3181@2|Bacteria,1NRB0@1224|Proteobacteria,2W0ZN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_220715_2	929712.KI912613_gene4258	1.06e-20	95.9	COG2066@1|root,COG2905@1|root,COG2066@2|Bacteria,COG2905@2|Bacteria,2GKAV@201174|Actinobacteria,4CRGA@84995|Rubrobacteria	84995|Rubrobacteria	ET	Glutaminase	-	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase,cNMP_binding
k59_581109_1	1265505.ATUG01000003_gene107	2.32e-53	182.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,42RH4@68525|delta/epsilon subdivisions,2WNQ0@28221|Deltaproteobacteria,2MNDR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
k59_351703_1	1192034.CAP_1091	4.51e-33	130.0	COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,42UU6@68525|delta/epsilon subdivisions,2X85I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_413274_1	1242864.D187_000934	2.15e-09	60.5	COG1668@1|root,COG1668@2|Bacteria,1R3RG@1224|Proteobacteria,43B64@68525|delta/epsilon subdivisions,2X6JN@28221|Deltaproteobacteria,2YVQ4@29|Myxococcales	28221|Deltaproteobacteria	CP	sodium ABC transporter, permease	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,Abi
k59_448831_2	227377.CBU_2017	1.28e-35	128.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1JCA4@118969|Legionellales	118969|Legionellales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_645399_1	330214.NIDE0527	1.69e-94	286.0	COG0585@1|root,COG0585@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_581118_1	1000565.METUNv1_03384	2.17e-27	106.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_581118_2	1349767.GJA_5466	8.62e-17	78.2	COG5343@1|root,COG5343@2|Bacteria,1N821@1224|Proteobacteria,2VJ7E@28216|Betaproteobacteria,476UK@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
k59_772515_1	1121930.AQXG01000001_gene1459	3.02e-10	68.6	COG0708@1|root,COG2373@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG5306@1|root,COG0708@2|Bacteria,COG2373@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG5306@2|Bacteria,4NXBA@976|Bacteroidetes,1IZ5A@117747|Sphingobacteriia	976|Bacteroidetes	Q	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Invasin_D3
k59_972939_1	1000565.METUNv1_00166	2.2e-131	382.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,2KVQU@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_279231_1	582899.Hden_0685	2.49e-139	404.0	COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,2U4HP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k59_515757_1	243365.CV_2032	1.84e-81	253.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,2KPH1@206351|Neisseriales	206351|Neisseriales	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_317173_1	640081.Dsui_0366	4.76e-159	486.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales	206389|Rhodocyclales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_220729_1	438753.AZC_1630	1.08e-23	97.8	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2TRYX@28211|Alphaproteobacteria,3EYPG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	MA20_43555	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_873655_1	330214.NIDE4181	6.04e-35	129.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	2.7.13.3	ko:K03407,ko:K03832	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035	2.C.1.1	-	-	CarbopepD_reg_2,GUN4,Gram_pos_anchor,HAMP,NIT,TonB_2,TonB_C,Trypsin_2
k59_873655_2	330214.NIDE4180	1.35e-104	306.0	COG2353@1|root,COG2353@2|Bacteria	2|Bacteria	O	YceI-like domain	Cj0420	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_448845_2	465541.ATCJ01000005_gene6232	1.9e-38	137.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
k59_156204_1	388051.AUFE01000002_gene495	2.97e-85	271.0	COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,1K2XV@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	xsc	-	2.3.3.15	ko:K03852	ko00430,map00430	-	R05651	RC02903,RC02909	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_25855_1	864051.BurJ1DRAFT_4285	1.43e-69	231.0	COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,2VNCR@28216|Betaproteobacteria,1KKHC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
k59_940284_1	314285.KT71_19313	1.22e-05	48.1	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,1RNA2@1236|Gammaproteobacteria,1J6SQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	-	-	-	-	-	-	-	-	-	Nramp
k59_940284_2	1530186.JQEY01000001_gene681	1.25e-34	132.0	COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2TRZP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	nahG	-	1.14.13.1	ko:K00480	ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00621,map00624,map00626,map01100,map01120,map01220	-	R00818,R05632,R06915,R06936,R06939	RC00389	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
k59_1003990_1	671143.DAMO_0012	1.72e-75	243.0	COG1966@1|root,COG1966@2|Bacteria,2NNP2@2323|unclassified Bacteria	2|Bacteria	T	5TM C-terminal transporter carbon starvation CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
k59_123478_2	1120983.KB894577_gene3579	2.33e-43	149.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2U6JP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_905292_1	945713.IALB_1687	3.42e-68	222.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM_1	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_772539_1	945713.IALB_0301	4.03e-51	174.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gdhA	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_515778_1	1123393.KB891328_gene576	1.28e-88	275.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,1KRAY@119069|Hydrogenophilales	119069|Hydrogenophilales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_515779_1	76114.ebA4662	7.02e-82	251.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2VIUW@28216|Betaproteobacteria,2KUNG@206389|Rhodocyclales	206389|Rhodocyclales	E	HMGL-like	hmgL	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_57564_1	1125863.JAFN01000001_gene581	8.01e-87	280.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	CBS domain containing protein	ccaA	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
k59_250005_1	395493.BegalDRAFT_2645	2.11e-83	255.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_159346_1	261292.Nit79A3_2926	1.14e-136	396.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,371TY@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_29099_1	290317.Cpha266_1157	1.83e-23	98.2	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
k59_648580_1	198628.Dda3937_02686	5.57e-17	85.1	COG4992@1|root,COG4992@2|Bacteria,1R6U9@1224|Proteobacteria,1RMRF@1236|Gammaproteobacteria,2JC4K@204037|Dickeya	1236|Gammaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	patA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0033094,GO:0034641,GO:0036094,GO:0042402,GO:0042802,GO:0043167,GO:0043168,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901565,GO:1901575	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R01155,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iECIAI1_1343.ECIAI1_3220,iECSF_1327.ECSF_2916,iECs_1301.ECs3955,iZ_1308.Z4426	Aminotran_3
k59_94803_1	1485544.JQKP01000004_gene464	7.76e-84	259.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,44WG4@713636|Nitrosomonadales	28216|Betaproteobacteria	P	NMT1-like family	nasF	-	-	ko:K02051,ko:K15576,ko:K22067	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko02000,ko02022	3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17	-	-	NMT1_2
k59_616291_1	945713.IALB_0498	3.61e-23	94.0	COG2825@1|root,COG2825@2|Bacteria	2|Bacteria	M	unfolded protein binding	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_616291_2	945713.IALB_0497	3.67e-78	254.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_126725_1	1157708.KB907460_gene1475	1.81e-61	204.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,4A9MZ@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the GMC oxidoreductase family	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_452002_1	264732.Moth_2270	2.07e-89	272.0	COG1082@1|root,COG1082@2|Bacteria,1TRGF@1239|Firmicutes,248GM@186801|Clostridia,42FYQ@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Xylose isomerase domain-containing protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_452002_2	94624.Bpet0506	1.8e-14	74.7	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VK73@28216|Betaproteobacteria,3T1VT@506|Alcaligenaceae	28216|Betaproteobacteria	S	ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_1007117_1	1231190.NA8A_05403	2.04e-48	167.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,43GQV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_1007117_2	1123023.JIAI01000001_gene7376	0.000665	41.6	COG0726@1|root,COG0726@2|Bacteria,2GM0X@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_519131_1	1485544.JQKP01000012_gene2118	1.56e-73	233.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,44UYU@713636|Nitrosomonadales	28216|Betaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_519131_2	649831.L083_4534	3.53e-11	64.7	COG1595@1|root,COG1595@2|Bacteria,2IG3F@201174|Actinobacteria,4DIT8@85008|Micromonosporales	201174|Actinobacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	-
k59_452006_1	1286631.X805_22950	1.01e-30	114.0	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2VS76@28216|Betaproteobacteria,1KPAT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,CMD
k59_355044_1	1480694.DC28_11625	6.35e-104	321.0	COG1166@1|root,COG1166@2|Bacteria,2J9X5@203691|Spirochaetes	203691|Spirochaetes	H	arginine decarboxylase	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_682718_2	290512.Paes_0705	9.65e-31	113.0	COG1945@1|root,COG1945@2|Bacteria,1FDKS@1090|Chlorobi	1090|Chlorobi	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
k59_846104_1	1229909.NSED_09005	4.92e-102	312.0	COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_908436_1	765911.Thivi_1829	2.53e-43	150.0	COG0697@1|root,COG0697@2|Bacteria,1RJFE@1224|Proteobacteria,1RZF0@1236|Gammaproteobacteria,1WWYW@135613|Chromatiales	135613|Chromatiales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1026149_2	323848.Nmul_A0754	4.73e-107	310.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,3722Z@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_280995_1	75379.Tint_2521	6.24e-52	175.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1KJ0U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_191498_1	381666.H16_B1740	1.35e-61	202.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VM40@28216|Betaproteobacteria,1KGIX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_908445_1	365044.Pnap_1858	1.57e-55	186.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,4AB65@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	odhL	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_320202_2	1485544.JQKP01000002_gene1615	5.35e-11	61.2	COG0664@1|root,COG0664@2|Bacteria,1NBRS@1224|Proteobacteria,2WCFJ@28216|Betaproteobacteria,44VZA@713636|Nitrosomonadales	28216|Betaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_682737_1	1121937.AUHJ01000003_gene3335	2.51e-62	199.0	COG3170@1|root,COG3170@2|Bacteria,1RDXQ@1224|Proteobacteria,1T42I@1236|Gammaproteobacteria,46DBE@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
k59_876961_1	1219035.NT2_02_05590	1.1e-40	145.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_386457_1	96561.Dole_1719	6.07e-37	149.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_775345_1	1442599.JAAN01000042_gene3059	2.73e-72	237.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1RYK4@1236|Gammaproteobacteria,1X3CR@135614|Xanthomonadales	135614|Xanthomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_538416_2	903818.KI912269_gene335	9.79e-74	232.0	COG0538@1|root,COG0538@2|Bacteria	2|Bacteria	C	isocitrate dehydrogenase activity	icd	GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_682745_1	1304885.AUEY01000005_gene819	7.31e-26	101.0	COG1150@1|root,COG1150@2|Bacteria,1N2IK@1224|Proteobacteria,42RP6@68525|delta/epsilon subdivisions,2WQ1G@28221|Deltaproteobacteria,2MQ1M@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	Fer4_17,Fer4_9
k59_159413_1	1229909.NSED_05590	1.05e-36	131.0	arCOG03622@1|root,arCOG03622@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_452859_1	187272.Mlg_0246	8.39e-100	315.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales	135613|Chromatiales	C	PFAM malic	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_977369_1	640081.Dsui_0604	2.38e-174	491.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,2KVBG@206389|Rhodocyclales	206389|Rhodocyclales	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_95730_1	794903.OPIT5_02770	1.32e-90	277.0	COG0600@1|root,COG0600@2|Bacteria,46XNS@74201|Verrucomicrobia,3K9TQ@414999|Opitutae	414999|Opitutae	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15577	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	BPD_transp_1
k59_95730_2	313628.LNTAR_24124	1.29e-37	138.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	nrtA	-	-	ko:K15576,ko:K15598	ko00910,ko02010,map00910,map02010	M00438,M00442	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2,3.A.1.17.3,3.A.1.17.6	-	-	NMT1,NMT1_2
k59_794329_1	1123392.AQWL01000002_gene1924	1.37e-29	117.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VJ5X@28216|Betaproteobacteria,1KRAX@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
k59_1026639_1	1121015.N789_14160	1.72e-64	221.0	COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,1RRK4@1236|Gammaproteobacteria,1X43Z@135614|Xanthomonadales	135614|Xanthomonadales	S	Phage portal protein, lambda family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal_2
k59_416881_2	323848.Nmul_A0564	4.98e-44	155.0	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,371X2@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_909274_1	42256.RradSPS_0627	3.78e-48	166.0	COG0477@1|root,COG2814@2|Bacteria,2GMBQ@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_253580_2	1380391.JIAS01000001_gene2787	1.77e-06	50.1	COG2128@1|root,COG2128@2|Bacteria,1RD1K@1224|Proteobacteria,2U6ZZ@28211|Alphaproteobacteria,2JU9D@204441|Rhodospirillales	204441|Rhodospirillales	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_416882_1	864051.BurJ1DRAFT_4851	8.33e-94	288.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2VHK0@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Malonyl-CoA decarboxylase	matA	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
k59_160279_1	1397527.Q670_05870	2.08e-188	535.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1TJAF@1236|Gammaproteobacteria,1XP37@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_192379_1	335543.Sfum_1181	1.67e-60	204.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_253582_1	497964.CfE428DRAFT_2899	2.69e-63	202.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_649487_1	94624.Bpet1667	1.19e-17	82.4	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria,3T3AT@506|Alcaligenaceae	28216|Betaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	4.1.3.30,5.4.2.9	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	-	R00409,R00661	RC00286,RC00287,RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_649487_2	373903.Hore_10880	1.12e-33	123.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,3WAN3@53433|Halanaerobiales	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01704,ko:K20453	ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R10170	RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_481747_1	1411123.JQNH01000001_gene3657	1.02e-245	699.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	MA20_17495	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_481747_2	1245469.S58_51900	1.82e-45	152.0	COG2010@1|root,COG2010@2|Bacteria,1RIV2@1224|Proteobacteria,2U9C5@28211|Alphaproteobacteria,3JZ5J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
k59_481747_3	189753.AXAS01000044_gene6200	2.34e-31	116.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2U72E@28211|Alphaproteobacteria,3JUV9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfur oxidation protein SoxY	MA20_17510	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
k59_716374_1	156889.Mmc1_2358	1.14e-52	182.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2U4RP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
k59_748897_1	936455.KI421499_gene3180	3.08e-48	162.0	COG1176@1|root,COG1176@2|Bacteria,1PE8C@1224|Proteobacteria,2U3DM@28211|Alphaproteobacteria,3K3BG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
k59_748897_2	1037409.BJ6T_56670	8.6e-13	66.6	COG1177@1|root,COG1177@2|Bacteria,1NTF5@1224|Proteobacteria,2U2YS@28211|Alphaproteobacteria,3K2P6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
k59_847078_2	696747.NIES39_J05960	2.08e-06	53.1	COG1216@1|root,COG1216@2|Bacteria,1G2PE@1117|Cyanobacteria,1H8A3@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_321036_1	95619.PM1_0217765	1.5e-24	108.0	COG2369@1|root,COG2369@2|Bacteria,1MY2T@1224|Proteobacteria,1RR6M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phage Mu protein F like protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_Mu_F
k59_909302_1	118166.JH976537_gene2633	3.37e-05	45.1	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1G4JM@1117|Cyanobacteria,1HACJ@1150|Oscillatoriales	1117|Cyanobacteria	P	COG0475 Kef-type K transport systems, membrane components	-	-	-	ko:K11745	-	-	-	-	ko00000,ko02000	2.A.37.1.1	-	-	Na_H_Exchanger,TrkA_N
k59_909302_2	118166.JH976537_gene2632	9.62e-68	213.0	COG2249@1|root,COG2249@2|Bacteria,1G57U@1117|Cyanobacteria,1HEJ4@1150|Oscillatoriales	1117|Cyanobacteria	S	Flavodoxin-like fold	-	-	-	ko:K03923,ko:K11748	-	-	-	-	ko00000,ko02000	2.A.37.1.2	-	-	Flavodoxin_2
k59_30075_1	1122927.KB895429_gene371	8.56e-32	126.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,4H9ZM@91061|Bacilli,26S70@186822|Paenibacillaceae	91061|Bacilli	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	2.4.2.8,6.3.4.19	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01132,R01229,R02142,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_356009_1	713587.THITH_08090	3.17e-06	49.3	COG3945@1|root,COG3945@2|Bacteria,1N0BD@1224|Proteobacteria,1SG9J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_356009_2	1026882.MAMP_01354	1.67e-36	135.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,460ES@72273|Thiotrichales	72273|Thiotrichales	MU	type I secretion outer membrane protein, TolC	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_748924_1	1229909.NSED_09210	7.47e-17	77.4	COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_748924_2	1229909.NSED_09215	4.26e-109	324.0	COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_95789_1	761193.Runsl_5057	1.1e-10	65.1	COG3464@1|root,COG3464@2|Bacteria,4NR8V@976|Bacteroidetes,47TD6@768503|Cytophagia	976|Bacteroidetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_61661_1	857293.CAAU_0724	3.6e-29	113.0	COG1023@1|root,COG1023@2|Bacteria,1UHN4@1239|Firmicutes,25E7N@186801|Clostridia,36H92@31979|Clostridiaceae	186801|Clostridia	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_649537_1	159087.Daro_2836	4.58e-78	245.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KVIV@206389|Rhodocyclales	206389|Rhodocyclales	M	lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_847109_1	1123253.AUBD01000007_gene584	4.61e-73	228.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1X4CF@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes a key regulatory step in fatty acid biosynthesis	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_748937_1	391625.PPSIR1_32844	1.9e-41	152.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,42NNY@68525|delta/epsilon subdivisions,2WKK6@28221|Deltaproteobacteria,2YUFS@29|Myxococcales	28221|Deltaproteobacteria	P	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_416938_1	1174528.JH992891_gene368	0.0003	48.5	COG3344@1|root,COG3344@2|Bacteria,1GHVI@1117|Cyanobacteria,1JKPH@1189|Stigonemataceae	1117|Cyanobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_909334_1	580340.Tlie_0169	2.6e-09	62.0	COG0491@1|root,COG0491@2|Bacteria,3TB33@508458|Synergistetes	508458|Synergistetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_160351_1	1121405.dsmv_1098	7.27e-64	206.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2MN0N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_909336_1	85643.Tmz1t_1672	3.32e-93	276.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2VH10@28216|Betaproteobacteria,2KXE1@206389|Rhodocyclales	206389|Rhodocyclales	F	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_1010099_2	1000565.METUNv1_00302	5.47e-101	304.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,2KUQ4@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_194613_1	177439.DP1810	7.83e-26	109.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,2MHWP@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_651623_1	82654.Pse7367_1013	5.26e-88	284.0	COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria,1H71S@1150|Oscillatoriales	1117|Cyanobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_483641_1	1382359.JIAL01000001_gene2204	1.6e-112	338.0	COG0535@1|root,COG0535@2|Bacteria,3Y2JV@57723|Acidobacteria,2JI93@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
k59_911447_1	1117647.M5M_13020	8.66e-19	90.5	COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
k59_911447_2	87626.PTD2_14184	1.21e-17	82.8	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q12B@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_162471_1	640081.Dsui_1452	1.31e-84	272.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,2KVW3@206389|Rhodocyclales	206389|Rhodocyclales	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_226936_1	330214.NIDE3904	6.52e-125	367.0	COG0438@1|root,COG0438@2|Bacteria,3J0Z0@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_162475_1	426117.M446_1228	5.63e-45	159.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,1JX9Q@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_323105_2	1005048.CFU_0794	2.95e-51	165.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,474F2@75682|Oxalobacteraceae	28216|Betaproteobacteria	KT	cheY-homologous receiver domain	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_323105_3	76114.ebA1749	4.71e-26	101.0	COG0835@1|root,COG0835@2|Bacteria,1N07Q@1224|Proteobacteria,2VU6N@28216|Betaproteobacteria,2KX20@206389|Rhodocyclales	206389|Rhodocyclales	NT	Chemotaxis signal transduction protein	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
k59_226939_1	395494.Galf_0370	1.9e-133	393.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,44VDT@713636|Nitrosomonadales	28216|Betaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_911459_2	330214.NIDE4152	4.95e-42	149.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PE,Phosphodiest
k59_911460_1	237368.SCABRO_04028	9.36e-16	77.0	COG0644@1|root,COG0664@1|root,COG0644@2|Bacteria,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	prnA	-	1.14.19.9	ko:K07058,ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_5,Trp_halogenase,cNMP_binding
k59_911460_2	479434.Sthe_0598	5.2e-30	123.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi	200795|Chloroflexi	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
k59_194637_1	94624.Bpet4348	1.09e-90	292.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,3T6RJ@506|Alcaligenaceae	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_130018_3	945713.IALB_0155	2.44e-31	118.0	COG1932@1|root,COG1932@2|Bacteria	2|Bacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1027819_1	1121405.dsmv_2238	6.84e-120	352.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria,2MHX4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	dsrP	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_323114_1	1562701.BBOF01000067_gene1905	6.69e-40	145.0	COG0413@1|root,COG0801@1|root,COG0413@2|Bacteria,COG0801@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria,1K06R@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_323114_2	1123392.AQWL01000001_gene1418	8.78e-67	209.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria,1KSHA@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Deoxynucleoside kinase	-	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_32469_1	583345.Mmol_1301	5.72e-42	149.0	COG0421@1|root,COG0421@2|Bacteria,1RBWW@1224|Proteobacteria,2VK7S@28216|Betaproteobacteria,2KMEK@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_418949_1	269799.Gmet_0373	3.57e-42	148.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,42NDW@68525|delta/epsilon subdivisions,2WMF0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q2
k59_63810_1	1049564.TevJSym_bf00260	6.07e-72	241.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1J56J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Small-conductance mechanosensitive channel	kefA	GO:0005575,GO:0005623,GO:0005886,GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016020,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0044464,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K05802,ko:K22051	-	-	-	-	ko00000,ko02000	1.A.23.1.1,1.A.23.1.2,1.A.23.1.3	-	-	MS_channel,MscS_TM,MscS_porin
k59_32480_1	864051.BurJ1DRAFT_3336	2.66e-47	162.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,2VPWJ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	sulfite reductase, dissimilatory-type alpha subunit	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_420472_1	1121472.AQWN01000007_gene1136	4.03e-122	369.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24DPN@186801|Clostridia,260G2@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM Acetoacetyl-CoA synthase	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_913066_1	85643.Tmz1t_0912	1.68e-52	167.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,2KWJU@206389|Rhodocyclales	206389|Rhodocyclales	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
k59_913066_2	948106.AWZT01000013_gene946	3.02e-38	132.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2VUN8@28216|Betaproteobacteria,1K7MC@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Phosphoribosyl-ATP	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
k59_541036_1	1280948.HY36_12165	8.75e-07	57.4	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,2TRNA@28211|Alphaproteobacteria,43Z0S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	KL	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
k59_1028708_1	436308.Nmar_0316	4.72e-126	360.0	COG0052@1|root,arCOG04245@2157|Archaea,41SG7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1028708_2	1131266.ARWQ01000010_gene28	4.87e-51	169.0	COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_881600_1	211165.AJLN01000079_gene367	4.18e-160	472.0	COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria,1JJZ1@1189|Stigonemataceae	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_324993_1	862908.BMS_3235	1.12e-34	127.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2MSTQ@213481|Bdellovibrionales,2WIQR@28221|Deltaproteobacteria	213481|Bdellovibrionales	D	Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_391745_1	76114.ebA844	1.99e-163	466.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,2KUDX@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_541073_1	637389.Acaty_c2086	1.1e-30	117.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,2NBWQ@225057|Acidithiobacillales	225057|Acidithiobacillales	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_485170_1	311424.DhcVS_176	1.49e-30	121.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2G62W@200795|Chloroflexi,34D3Z@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_485170_2	316067.Geob_1643	9.27e-27	108.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,43TK1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdnG-2	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_257118_1	1047013.AQSP01000133_gene2107	4.25e-41	152.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k59_1011828_1	762903.Pedsa_1357	3.72e-37	135.0	COG1104@1|root,COG1104@2|Bacteria,4NG58@976|Bacteroidetes,1IQ14@117747|Sphingobacteriia	976|Bacteroidetes	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_1011828_2	330214.NIDE4023	3.99e-85	253.0	COG1959@1|root,COG1959@2|Bacteria,3J18M@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
k59_457104_2	243231.GSU3083	5.05e-135	391.0	COG2801@1|root,COG2801@2|Bacteria,1R7WH@1224|Proteobacteria,43AIP@68525|delta/epsilon subdivisions,2X5YX@28221|Deltaproteobacteria	1224|Proteobacteria	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_325048_1	156889.Mmc1_2224	3.78e-63	204.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	BQ	Including yeast histone deacetylase and acetoin utilization protein	hdaH	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_325048_2	1101189.AQUO01000002_gene777	7.3e-28	110.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,2PUNA@265|Paracoccus	28211|Alphaproteobacteria	L	Radical SAM	MA20_42330	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1011857_1	1122197.ATWI01000014_gene1	3.25e-39	143.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,465RW@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_257149_1	1502770.JQMG01000001_gene2123	8.94e-47	160.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VIK6@28216|Betaproteobacteria,2KMCY@206350|Nitrosomonadales	206350|Nitrosomonadales	S	TIGRFAM coenzyme PQQ biosynthesis protein E	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_257149_2	1236959.BAMT01000001_gene1442	4.75e-32	115.0	2E4CK@1|root,32Z81@2|Bacteria,1N7JR@1224|Proteobacteria,2VVSC@28216|Betaproteobacteria,2KN6H@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM coenzyme PQQ synthesis	-	-	-	ko:K06138	-	-	-	-	ko00000	-	-	-	PqqD
k59_257149_3	265072.Mfla_1682	2.8e-65	205.0	COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2VI0X@28216|Betaproteobacteria,2KMD0@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
k59_325076_1	228399.appser1_10990	9.1e-14	75.5	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1S0G9@1236|Gammaproteobacteria,1Y72S@135625|Pasteurellales	135625|Pasteurellales	S	Calcineurin-like phosphoesterase superfamily domain	Z012_05430	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
k59_1011870_2	1245471.PCA10_45530	1.2e-56	199.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1YDJY@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iECs_1301.ECs5024,iG2583_1286.G2583_4866	Acyltransferase
k59_325095_1	861299.J421_0784	1.25e-38	145.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
k59_420581_1	368407.Memar_0028	1.1e-10	65.1	COG0609@1|root,arCOG01007@2157|Archaea,2XT1A@28890|Euryarchaeota,2NAJI@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM transport system permease protein	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_541169_1	697282.Mettu_1012	2.77e-70	227.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XE5A@135618|Methylococcales	135618|Methylococcales	T	SMART Signal transduction response regulator, receiver region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_257185_1	314264.ROS217_20132	2.89e-21	93.6	2DG8R@1|root,2ZUYV@2|Bacteria,1RG4Q@1224|Proteobacteria,2U6V3@28211|Alphaproteobacteria,46PSZ@74030|Roseovarius	28211|Alphaproteobacteria	H	Sulfotransferase family	-	-	2.8.2.2	ko:K01015	ko00140,map00140	-	R00629,R03405,R08977,R08978	RC00007,RC00231,RC00341	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_1
k59_257192_1	1051985.l11_20910	1.89e-08	56.6	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,2KPK1@206351|Neisseriales	206351|Neisseriales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_257192_2	1454004.AW11_02684	3.66e-28	108.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,1KQHZ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_485249_1	1525715.IX54_13440	4.13e-13	66.2	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,2PXA5@265|Paracoccus	28211|Alphaproteobacteria	S	Thioesterase-like superfamily	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_485249_2	948106.AWZT01000011_gene1997	5.97e-62	201.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,1K2TQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_420610_1	243233.MCA1273	3.02e-72	231.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_541201_1	546266.NEIMUCOT_05264	1.45e-61	203.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1028798_1	330214.NIDE1167	6.56e-103	332.0	COG1201@1|root,COG1201@2|Bacteria	2|Bacteria	L	RNA secondary structure unwinding	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_420625_1	485913.Krac_1499	1.98e-35	138.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_541221_1	1121382.JQKG01000008_gene1058	2.04e-30	122.0	COG0170@1|root,COG0170@2|Bacteria,1WMV9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	dolichyl monophosphate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_257228_1	1385935.N836_28750	4.26e-52	177.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
k59_795989_1	887898.HMPREF0551_1867	1.41e-97	308.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,1K1T3@119060|Burkholderiaceae	28216|Betaproteobacteria	U	type IV pilus secretin PilQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_420640_1	69328.PVLB_09320	4.07e-05	50.1	2DR9Y@1|root,33AUY@2|Bacteria	2|Bacteria	L	HNH endonuclease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3,NUMOD4
k59_325177_1	395494.Galf_2724	4.88e-76	249.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,44VKX@713636|Nitrosomonadales	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_1028808_1	595460.RRSWK_04087	5.99e-71	226.0	COG3039@1|root,COG3039@2|Bacteria,2J1M4@203682|Planctomycetes	203682|Planctomycetes	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_1011978_1	330214.NIDE1367	6.41e-88	275.0	COG0155@1|root,COG0155@2|Bacteria,3J10S@40117|Nitrospirae	40117|Nitrospirae	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_257261_1	290397.Adeh_0444	6.75e-52	176.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,42N9C@68525|delta/epsilon subdivisions,2WJ2J@28221|Deltaproteobacteria,2YXSZ@29|Myxococcales	28221|Deltaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_257264_1	1033802.SSPSH_003327	1.38e-70	228.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_257264_2	62928.azo3303	1.68e-14	73.2	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,2KUWI@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_796006_1	1304885.AUEY01000022_gene3407	3.8e-44	155.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42PMQ@68525|delta/epsilon subdivisions,2WKB8@28221|Deltaproteobacteria,2MIF9@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_913314_1	1297742.A176_01465	2.54e-07	58.2	COG2755@1|root,COG5640@1|root,COG2755@2|Bacteria,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,Lipase_GDSL_2,Trypsin
k59_283738_1	1229909.NSED_08500	6.46e-56	197.0	arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1012009_1	1123320.KB889741_gene5290	2.13e-09	62.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,NPCBM_assoc,PEGA
k59_325250_1	316278.SynRCC307_0761	2.25e-11	65.5	COG2867@1|root,COG2867@2|Bacteria,1G77Q@1117|Cyanobacteria,1H0A0@1129|Synechococcus	1117|Cyanobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_779942_1	1121024.AUCD01000004_gene1548	2.51e-33	132.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,4HB0P@91061|Bacilli,27FPR@186828|Carnobacteriaceae	91061|Bacilli	L	L COG3328 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_325268_1	288000.BBta_1089	7.76e-21	99.8	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2TRUN@28211|Alphaproteobacteria,3JQV9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Phosphopantetheine attachment site	dhbF	-	6.3.2.14	ko:K02364	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
k59_485365_1	694429.Pyrfu_0207	2.65e-45	158.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
k59_325276_1	443598.AUFA01000002_gene2684	7.08e-62	206.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,3JVT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_325276_2	312153.Pnuc_0709	5.39e-08	52.4	COG2841@1|root,COG2841@2|Bacteria,1N760@1224|Proteobacteria,2VVX0@28216|Betaproteobacteria,1KACR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF465)	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	DUF465
k59_779960_1	1089549.AZUQ01000001_gene2829	1.26e-19	93.6	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,4F08Y@85014|Glycomycetales	201174|Actinobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	1.14.12.25	ko:K10619	ko00622,ko01120,ko01220,map00622,map01120,map01220	M00539	R05247	RC00267	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
k59_546318_2	1094980.Mpsy_0128	5.86e-16	78.6	COG1048@1|root,arCOG01697@2157|Archaea,2XTIZ@28890|Euryarchaeota,2NAHN@224756|Methanomicrobia	224756|Methanomicrobia	C	Aconitase C-terminal domain	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0714	Aconitase,Aconitase_C
k59_1031663_1	945713.IALB_0375	2.14e-79	249.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria	2|Bacteria	J	transcription antitermination	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_798921_1	551789.ATVJ01000003_gene249	1.03e-75	248.0	COG0308@1|root,COG0308@2|Bacteria,1MUV3@1224|Proteobacteria,2TVKQ@28211|Alphaproteobacteria,43WUP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_546336_1	1266925.JHVX01000005_gene1869	4.19e-165	476.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,3729Y@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_546336_2	519989.ECTPHS_01874	3.85e-08	54.7	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_546341_1	1384056.N787_07105	3.79e-88	282.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitrite reductase	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_1031679_1	272630.MexAM1_META1p0329	1.61e-59	201.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,1JT9T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_798965_1	1122605.KB893631_gene3909	2.46e-58	196.0	COG0719@1|root,COG0719@2|Bacteria,4NFPG@976|Bacteroidetes,1IQF5@117747|Sphingobacteriia	976|Bacteroidetes	O	FeS assembly protein SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_798965_2	1469245.JFBG01000076_gene136	0.000677	41.2	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_546375_1	1146883.BLASA_4559	2.93e-81	253.0	2DBC4@1|root,2Z8BS@2|Bacteria,2GYBF@201174|Actinobacteria,4ERMM@85013|Frankiales	201174|Actinobacteria	S	Responsible for the hydrolysis of barbituric acid (2,4,6-trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid	bar	-	3.5.2.1,3.5.2.15	ko:K03383,ko:K19794	ko00240,ko00791,ko01100,ko01120,map00240,map00791,map01100,map01120	-	R02139,R05561,R10777	RC00632,RC00680,RC01423,RC03058	ko00000,ko00001,ko01000	-	-	-	Amido_AtzD_TrzD
k59_798979_1	880072.Desac_1527	7.35e-125	387.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MQ80@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1031747_1	439235.Dalk_0260	1.55e-31	120.0	COG0789@1|root,COG0789@2|Bacteria,1N7M7@1224|Proteobacteria,42WAT@68525|delta/epsilon subdivisions,2WRPH@28221|Deltaproteobacteria,2MMFX@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM regulatory protein MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_799051_1	1268622.AVS7_01212	1.55e-59	188.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria,4ADYP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
k59_546516_1	357804.Ping_2652	2.42e-79	251.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	IS30 family	ISPlu1B	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_799216_1	760568.Desku_0590	5.76e-16	78.6	COG2414@1|root,COG2414@2|Bacteria,1VSI9@1239|Firmicutes,24YQQ@186801|Clostridia	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_799216_2	1260251.SPISAL_00855	6.37e-45	152.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1X2PM@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4
k59_546625_1	1449351.RISW2_00085	5.8e-115	342.0	COG0683@1|root,COG0683@2|Bacteria,1RBGU@1224|Proteobacteria,2U6VH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_799256_1	391600.ABRU01000054_gene634	5.95e-05	45.1	COG3346@1|root,COG3346@2|Bacteria,1N5JU@1224|Proteobacteria,2UCJU@28211|Alphaproteobacteria,2KGZ3@204458|Caulobacterales	204458|Caulobacterales	S	SURF1-like protein	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_799256_2	384765.SIAM614_06178	2.34e-46	153.0	COG5349@1|root,COG5349@2|Bacteria,1N0WU@1224|Proteobacteria,2UCE7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
k59_287322_1	1453501.JELR01000005_gene1719	1.13e-94	287.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,4651Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_287343_1	522306.CAP2UW1_3419	4.42e-143	424.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2VM8J@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
k59_287379_1	682795.AciX8_2424	3.27e-17	87.8	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
k59_546751_1	517418.Ctha_0106	4.49e-49	176.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_809048_1	1123248.KB893323_gene1630	3.24e-08	60.1	COG3104@1|root,COG3104@2|Bacteria,4NGWH@976|Bacteroidetes,1IVYE@117747|Sphingobacteriia	976|Bacteroidetes	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_1039307_1	592015.HMPREF1705_01946	1.28e-64	213.0	COG4799@1|root,COG4799@2|Bacteria,3TAED@508458|Synergistetes	508458|Synergistetes	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_809105_1	935557.ATYB01000010_gene82	2.28e-69	227.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,4B9NE@82115|Rhizobiaceae	28211|Alphaproteobacteria	EG	Dehydratase family	MA20_16960	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_809105_2	323848.Nmul_A0677	6.59e-22	90.1	COG3671@1|root,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria,373E8@32003|Nitrosomonadales	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1039399_1	1449346.JQMO01000003_gene2485	1.28e-41	145.0	COG2154@1|root,COG2154@2|Bacteria,2IHZE@201174|Actinobacteria,2M24Q@2063|Kitasatospora	201174|Actinobacteria	H	dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_1039479_2	1265505.ATUG01000001_gene4710	2.54e-112	332.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria,2MKR7@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_809321_1	426117.M446_4056	3.01e-47	166.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria,1JSHK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	oxc	-	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100	-	R01908	RC00620	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1039542_1	1148.1653395	2.53e-07	51.6	COG0064@1|root,COG0064@2|Bacteria,1G0H0@1117|Cyanobacteria,1H57V@1142|Synechocystis	1117|Cyanobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_1039542_2	386456.JQKN01000017_gene840	1.48e-52	172.0	COG4912@1|root,arCOG11010@2157|Archaea,2XWKG@28890|Euryarchaeota,23PIX@183925|Methanobacteria	183925|Methanobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
k59_809383_1	977880.RALTA_A2890	4.55e-90	294.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_809472_1	1123499.KB908024_gene1416	3.12e-21	100.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2VTVG@28216|Betaproteobacteria,2KQ0G@206351|Neisseriales	206351|Neisseriales	EGP	Transmembrane secretion effector	-	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_3
k59_1039687_1	1218076.BAYB01000035_gene5282	1.24e-36	139.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,1K2BJ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	CBS domain containing protein	corB	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_809504_1	1089547.KB913013_gene4325	7.02e-17	80.1	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,47KS7@768503|Cytophagia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_809563_1	330214.NIDE3965	7.42e-67	207.0	COG0041@1|root,COG0041@2|Bacteria,3J0P8@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_809563_2	330214.NIDE3966	4.89e-74	237.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cvaA	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,OEP
k59_1039802_1	1286106.MPL1_07443	5.86e-52	169.0	COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,1T0AA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer Membrane Lipoprotein	blc4	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
k59_1039802_2	1121935.AQXX01000084_gene5364	1.25e-09	59.7	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,1XHT8@135619|Oceanospirillales	135619|Oceanospirillales	S	NAD FAD-binding protein	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase
k59_1039873_1	1280954.HPO_13035	3.98e-76	236.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2TRJT@28211|Alphaproteobacteria,43XSH@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
k59_809687_1	1286631.X805_36650	6.46e-37	131.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2VHCP@28216|Betaproteobacteria,1KJRC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_809687_2	864051.BurJ1DRAFT_0379	2.34e-25	97.1	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,1KM1K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_1039902_1	232721.Ajs_1712	8.52e-62	202.0	COG3971@1|root,COG3971@2|Bacteria,1R3UP@1224|Proteobacteria,2VNA2@28216|Betaproteobacteria,4ABDW@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1039903_1	159450.NH14_08195	1.07e-98	298.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VNZH@28216|Betaproteobacteria,1K12G@119060|Burkholderiaceae	28216|Betaproteobacteria	C	e1 component (alpha subunit)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_809715_1	1163617.SCD_n02025	2.31e-83	260.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2VKBR@28216|Betaproteobacteria	28216|Betaproteobacteria	CP	NADH Ubiquinone plastoquinone (Complex I)	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
k59_809727_1	543728.Vapar_0459	2.87e-44	164.0	COG4122@1|root,COG4122@2|Bacteria,1QWCT@1224|Proteobacteria,2VJBK@28216|Betaproteobacteria,4ACMD@80864|Comamonadaceae	28216|Betaproteobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1039958_1	1000565.METUNv1_03886	4.36e-76	240.0	COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,2VNAR@28216|Betaproteobacteria,2KWAT@206389|Rhodocyclales	206389|Rhodocyclales	ET	COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
k59_1039967_1	34506.g3030	2.1e-31	124.0	COG0488@1|root,KOG0927@2759|Eukaryota	2759|Eukaryota	T	ATPase activity	-	-	-	ko:K15073	-	-	-	-	ko00000,ko04121	-	-	-	ABC_tran,DHDPS
k59_1039967_2	420324.KI911996_gene7845	1.85e-17	77.4	2C07J@1|root,32SWS@2|Bacteria,1N0NW@1224|Proteobacteria,2UCVR@28211|Alphaproteobacteria,1JV69@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1040005_1	748247.AZKH_2947	4.08e-67	221.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,2KU9G@206389|Rhodocyclales	206389|Rhodocyclales	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
k59_809901_1	1229909.NSED_03630	3.52e-177	510.0	COG0365@1|root,arCOG01529@2157|Archaea,41S8Z@651137|Thaumarchaeota	651137|Thaumarchaeota	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_810020_1	987059.RBXJA2T_14581	9.45e-107	313.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,1KJD5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_810086_1	1384056.N787_12380	1.82e-89	283.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1X4EX@135614|Xanthomonadales	135614|Xanthomonadales	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_1040309_1	1266925.JHVX01000003_gene530	2.13e-26	103.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,372E4@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_1040309_2	395495.Lcho_4011	1.78e-25	99.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,2VTX5@28216|Betaproteobacteria,1KMDJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_810146_1	1000565.METUNv1_00608	9.93e-120	370.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,2KV38@206389|Rhodocyclales	206389|Rhodocyclales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1040353_1	177437.HRM2_11810	1.51e-78	248.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WMEF@28221|Deltaproteobacteria,2MJFC@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1040382_2	582744.Msip34_0006	1.74e-35	124.0	COG1993@1|root,COG1993@2|Bacteria,1PU6Y@1224|Proteobacteria,2WCJF@28216|Betaproteobacteria,2KP0Y@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	DUF190
k59_1040382_3	1458275.AZ34_13100	7.63e-11	60.5	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2VUBZ@28216|Betaproteobacteria,4AEP4@80864|Comamonadaceae	28216|Betaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_1040427_2	330214.NIDE4314	4.4e-60	194.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1040489_1	195253.Syn6312_2004	1.8e-06	50.8	COG2202@1|root,COG2203@1|root,COG5001@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1GYX2@1129|Synechococcus	1117|Cyanobacteria	T	diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_1040489_2	1469245.JFBG01000011_gene814	5.57e-19	82.4	COG3427@1|root,COG3427@2|Bacteria,1RHUC@1224|Proteobacteria	1224|Proteobacteria	S	carbon monoxide dehydrogenase	coxG	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
k59_810350_1	945713.IALB_1488	3.4e-35	137.0	COG3291@1|root,COG4409@1|root,COG4935@1|root,COG3291@2|Bacteria,COG4409@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	wcoB	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Beta_helix,PKD,Reprolysin_4
k59_810384_1	880072.Desac_0866	4.33e-66	208.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,43CH0@68525|delta/epsilon subdivisions,2X7S8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1040667_1	1458427.BAWN01000012_gene705	6.98e-86	275.0	COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria,2WE9S@28216|Betaproteobacteria	28216|Betaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
k59_1040689_1	391038.Bphy_3039	1.06e-157	461.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,1K1UR@119060|Burkholderiaceae	28216|Betaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_810570_1	203122.Sde_1733	5.1e-30	117.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,464AZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767	NAD_kinase
k59_1040765_1	1459636.NTE_01850	3.14e-53	187.0	COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1040782_1	1500894.JQNN01000001_gene3796	5.6e-43	146.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR7N@28216|Betaproteobacteria,474AM@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Type II secretion system (T2SS), protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_810709_1	1000565.METUNv1_03798	5.04e-71	229.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,2KV63@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_810721_1	1229909.NSED_05805	3.79e-73	240.0	COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota	651137|Thaumarchaeota	P	CBS domain	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	CBS,TrkH
k59_810761_1	388413.ALPR1_04898	3.79e-52	180.0	COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,47K3E@768503|Cytophagia	976|Bacteroidetes	I	Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta)	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1040867_1	640511.BC1002_3528	3.62e-83	259.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VJ9R@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Transporter, DASS family	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
k59_1040867_2	887898.HMPREF0551_1000	2.21e-39	135.0	COG3080@1|root,COG3080@2|Bacteria,1RDZD@1224|Proteobacteria,2VTX9@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane	frdD	-	-	ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Fumarate_red_D
k59_810849_1	1268622.AVS7_01490	4.49e-43	150.0	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,2VR2C@28216|Betaproteobacteria,4AH9J@80864|Comamonadaceae	28216|Betaproteobacteria	H	Pfam:Methyltransf_6	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
k59_1040929_2	631362.Thi970DRAFT_04744	2.56e-21	86.3	2C5EY@1|root,32YQJ@2|Bacteria,1N8K7@1224|Proteobacteria,1SDU6@1236|Gammaproteobacteria,1X19C@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
k59_338316_1	1163617.SCD_n00733	2e-15	76.6	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2WHEI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_338316_2	762983.HMPREF9444_01369	7.83e-31	110.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1Y4TI@135624|Aeromonadales	135624|Aeromonadales	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_502095_1	1218075.BAYA01000034_gene6175	1.41e-23	99.8	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2WEFN@28216|Betaproteobacteria,1K2W5@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_143256_2	84531.JMTZ01000018_gene3898	1.35e-06	47.4	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria,1X89Z@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF2909)	VL23_10685	-	-	-	-	-	-	-	-	-	-	-	DUF2909
k59_731119_1	331869.BAL199_24109	3.22e-162	472.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,4BPZA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_665903_1	1349767.GJA_5137	3.9e-29	116.0	COG3391@1|root,COG3391@2|Bacteria,1R78P@1224|Proteobacteria,2VJ7I@28216|Betaproteobacteria,472JG@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_959595_1	105559.Nwat_0959	1.01e-86	279.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_402113_1	1227739.Hsw_1535	1.39e-20	93.2	COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes,47MS0@768503|Cytophagia	976|Bacteroidetes	V	Glycosyl Hydrolase Family 88	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
k59_402113_2	945713.IALB_2927	1.29e-24	103.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CBM_6,DUF1565,PDZ_2,Trypsin_2
k59_829214_1	903818.KI912268_gene1621	1.51e-54	179.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	yafV	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0030312,GO:0044464,GO:0050152,GO:0071944,GO:0106008	3.5.1.3,3.5.1.77,3.5.5.1	ko:K01459,ko:K01501,ko:K11206,ko:K13566	ko00250,ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00250,map00380,map00460,map00627,map00643,map00910,map01120	-	R00269,R00348,R00540,R01887,R03093,R03542,R05591,R07855	RC00010,RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,CN_hydrolase
k59_208211_1	887898.HMPREF0551_1900	6.68e-59	184.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2VQ0A@28216|Betaproteobacteria,1K6XR@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_208211_2	76114.ebC3	1.22e-22	88.6	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2VVNT@28216|Betaproteobacteria,2KXD6@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_991427_1	1123393.KB891316_gene1418	1.87e-47	163.0	COG2319@1|root,COG2319@2|Bacteria,1P8FD@1224|Proteobacteria,2W9VU@28216|Betaproteobacteria,1KSDI@119069|Hydrogenophilales	119069|Hydrogenophilales	S	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	WD40
k59_991427_2	292415.Tbd_2112	9.93e-146	426.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,1KS96@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Aminoacyl-tRNA editing domain	-	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_502692_1	438753.AZC_4210	4.15e-32	125.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TUAN@28211|Alphaproteobacteria,3EZN9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	MA20_03545	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_272696_1	1304885.AUEY01000004_gene943	1.02e-66	221.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MI0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_175892_1	444860.E3SJ18_9CAUD	7.96e-96	300.0	4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses  no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae	10662|Myoviridae	S	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_175892_2	445686.E3SL69_9CAUD	3.15e-09	56.6	4QE8Y@10239|Viruses,4QPGZ@28883|Caudovirales,4QISX@10662|Myoviridae	10662|Myoviridae	S	Recombination, repair and ssDNA binding protein UvsY	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_371164_2	580332.Slit_0354	2.54e-34	120.0	COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,2VWKA@28216|Betaproteobacteria,44WMD@713636|Nitrosomonadales	28216|Betaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_829230_1	526218.Sterm_1949	1.2e-19	93.6	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,379XF@32066|Fusobacteria	32066|Fusobacteria	GT	pyruvate, water dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_530435_1	195250.CM001776_gene3119	4.12e-70	234.0	COG1200@1|root,COG1200@2|Bacteria,1G17H@1117|Cyanobacteria,1GZ2C@1129|Synechococcus	1117|Cyanobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_12892_1	395494.Galf_2594	9.92e-121	350.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2VIA5@28216|Betaproteobacteria,44VFD@713636|Nitrosomonadales	28216|Betaproteobacteria	K	Transcriptional regulator	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_12892_2	402626.Rpic_2387	3.01e-63	209.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,1K2K5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_175902_1	96561.Dole_0997	8.56e-31	110.0	COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,42QXF@68525|delta/epsilon subdivisions,2WMRJ@28221|Deltaproteobacteria,2MJFT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	reductase, beta subunit	aprB	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
k59_371176_1	1348657.M622_04940	2.34e-67	225.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KXBU@206389|Rhodocyclales	206389|Rhodocyclales	C	PQQ-like domain	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_1018141_1	1121396.KB893058_gene2565	1.05e-42	150.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3,Peptidase_S9
k59_338938_2	443143.GM18_2543	0.000382	43.5	292XF@1|root,2ZQEX@2|Bacteria,1P8W2@1224|Proteobacteria,432F4@68525|delta/epsilon subdivisions,2WXUJ@28221|Deltaproteobacteria,43VN9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
k59_530441_1	1121405.dsmv_1320	1.1e-71	240.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_665954_1	545696.HOLDEFILI_03854	1.7e-37	132.0	COG1943@1|root,COG1943@2|Bacteria,1TSQ0@1239|Firmicutes,3VQJN@526524|Erysipelotrichia	526524|Erysipelotrichia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
k59_829252_2	330214.NIDE0809	4.81e-47	162.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,VCBS
k59_927107_1	991905.SL003B_3188	3.07e-37	134.0	COG3485@1|root,COG3485@2|Bacteria,1QBMH@1224|Proteobacteria,2TVTJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Catechol dioxygenase N terminus	chqB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006725,GO:0008150,GO:0008152,GO:0008199,GO:0009056,GO:0009712,GO:0009987,GO:0016491,GO:0016701,GO:0016702,GO:0018576,GO:0018958,GO:0019114,GO:0019336,GO:0019439,GO:0019614,GO:0019615,GO:0042952,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	1.13.11.1	ko:K03381	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R00817,R04258,R05299,R08114,R08115,R09134	RC00388,RC00535,RC01366	ko00000,ko00001,ko00002,ko01000	-	-	-	Dioxygenase_C,Dioxygenase_N
k59_927107_2	319795.Dgeo_2374	7.2e-22	93.2	COG0169@1|root,COG0169@2|Bacteria,1WIM8@1297|Deinococcus-Thermus	2|Bacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0030266,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N,ThiF
k59_305548_2	864069.MicloDRAFT_00001810	4.88e-71	224.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_28,HTH_29,HTH_33
k59_761127_1	375286.mma_2403	4.11e-68	228.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,472FR@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_238873_1	887062.HGR_04433	1.38e-92	284.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VK35@28216|Betaproteobacteria,4AA1P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	soxF	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
k59_371186_1	983917.RGE_36860	4.74e-107	323.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,1KJIQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_78343_1	373994.Riv7116_2466	5.79e-36	133.0	COG4671@1|root,COG4671@2|Bacteria,1G0X1@1117|Cyanobacteria,1HNIA@1161|Nostocales	1117|Cyanobacteria	S	PFAM Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
k59_110629_1	261292.Nit79A3_0785	3.01e-150	437.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,372AD@32003|Nitrosomonadales	28216|Betaproteobacteria	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_761131_1	330214.NIDE0519	7.83e-92	277.0	COG1131@1|root,COG1131@2|Bacteria,3J0JF@40117|Nitrospirae	40117|Nitrospirae	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_927112_1	1395516.PMO01_05935	4.33e-69	222.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_338949_1	398525.KB900701_gene3632	1.78e-107	318.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2U149@28211|Alphaproteobacteria,3JTNK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_16350	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_959656_1	398767.Glov_3242	2.14e-30	122.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,42PHS@68525|delta/epsilon subdivisions,2X5NU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_436482_1	323261.Noc_0785	5.17e-63	207.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Sigma54_activat
k59_787683_1	696748.ASU2_10150	2.53e-35	134.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1Y7X1@135625|Pasteurellales	135625|Pasteurellales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0043167,GO:0043169,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_829268_1	1288826.MSNKSG1_05601	4.04e-10	65.9	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,469QF@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_238881_1	330214.NIDE0268	6.49e-97	293.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
k59_927117_1	243277.VC_2606	1.35e-29	118.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1XSSX@135623|Vibrionales	135623|Vibrionales	P	Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K( ) H( ) antiport	kefB	-	-	ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_927117_2	1123269.NX02_25690	2.33e-09	58.2	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TSHC@28211|Alphaproteobacteria,2K0UX@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_665970_1	1031711.RSPO_c00535	6.01e-135	424.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_208273_1	1380355.JNIJ01000007_gene3233	1.79e-85	260.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,3JWN0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_371200_1	748247.AZKH_2861	1.16e-128	385.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,2KVUA@206389|Rhodocyclales	206389|Rhodocyclales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_698761_1	1191523.MROS_1473	3.97e-88	264.0	COG0009@1|root,COG0009@2|Bacteria	2|Bacteria	J	L-threonylcarbamoyladenylate synthase	yciO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
k59_78360_1	395493.BegalDRAFT_2908	1.18e-86	267.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,46072@72273|Thiotrichales	72273|Thiotrichales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_893185_1	1144275.COCOR_01587	5.19e-13	70.1	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PZJ@68525|delta/epsilon subdivisions,2WMGB@28221|Deltaproteobacteria,2YVBK@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_893185_2	1158345.JNLL01000001_gene175	5.94e-15	73.6	COG0476@1|root,COG0476@2|Bacteria,2G4P8@200783|Aquificae	200783|Aquificae	H	PFAM UBA THIF-type NAD FAD binding protein	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_143333_1	517418.Ctha_2628	3.17e-17	86.3	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1FENW@1090|Chlorobi	1090|Chlorobi	MU	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_MA_2
k59_467371_1	1463901.JOIY01000014_gene5647	3.32e-53	184.0	COG0001@1|root,COG0001@2|Bacteria,2IBG2@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_208286_1	945713.IALB_3054	7.84e-70	217.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	yihX	GO:0003674,GO:0003824,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.10,3.1.3.104,3.8.1.2	ko:K01560,ko:K07025,ko:K20866,ko:K21063	ko00010,ko00361,ko00625,ko00740,ko01100,ko01110,ko01120,map00010,map00361,map00625,map00740,map01100,map01110,map01120	M00125	R00947,R05287,R07280	RC00017,RC00078,RC00697	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase
k59_208286_2	869213.JCM21142_42083	2.09e-06	49.3	COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,47M2G@768503|Cytophagia	976|Bacteroidetes	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_12969_1	762376.AXYL_01692	2.74e-74	234.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJJQ@28216|Betaproteobacteria,3T3AX@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_402189_1	292415.Tbd_0096	3.4e-70	223.0	COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,2VKGK@28216|Betaproteobacteria	28216|Betaproteobacteria	M	phospholipase A1	pldA	-	3.1.1.32,3.1.1.4	ko:K01058	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110	-	R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000	-	-	-	PLA1
k59_78382_1	1336208.JADY01000002_gene310	1.55e-98	317.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_829313_1	1121403.AUCV01000019_gene3294	3.76e-65	211.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,42TEX@68525|delta/epsilon subdivisions,2WPG8@28221|Deltaproteobacteria,2MPWW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_402191_1	557598.LHK_00963	3.38e-13	68.9	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,2KPX5@206351|Neisseriales	206351|Neisseriales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
k59_1018167_1	1459636.NTE_02594	5.86e-100	295.0	COG0052@1|root,arCOG04245@2157|Archaea,41SG7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_305593_1	1229909.NSED_00705	1.24e-77	243.0	COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the HMG-CoA reductase family	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
k59_371226_1	886293.Sinac_4765	5.44e-11	74.7	COG3210@1|root,COG4733@1|root,COG3210@2|Bacteria,COG4733@2|Bacteria,2J50K@203682|Planctomycetes	203682|Planctomycetes	U	Pkd domain containing protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	-
k59_567949_1	945713.IALB_2058	1.96e-67	213.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_567949_2	743722.Sph21_3261	1.13e-11	67.8	COG1409@1|root,COG1520@1|root,COG1409@2|Bacteria,COG1520@2|Bacteria,4NFA9@976|Bacteroidetes,1IPWE@117747|Sphingobacteriia	976|Bacteroidetes	S	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PQQ,PQQ_2,PQQ_3
k59_632752_1	572547.Amico_1177	2.49e-35	138.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,3TA4Y@508458|Synergistetes	508458|Synergistetes	J	SMART CBS domain containing protein	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
k59_959708_1	1101195.Meth11DRAFT_2548	6.34e-08	58.9	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KKXA@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Neisseria PilC beta-propeller domain	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_829318_1	991905.SL003B_1257	2.17e-72	221.0	COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,2TTCK@28211|Alphaproteobacteria,4BQ4N@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	lrp	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
k59_861003_1	595494.Tola_2300	1.45e-42	154.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1Y3TV@135624|Aeromonadales	135624|Aeromonadales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_502788_1	1114964.L485_17130	1.69e-39	144.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_991523_1	234267.Acid_4751	1.68e-61	207.0	COG0517@1|root,COG0517@2|Bacteria,3Y6WE@57723|Acidobacteria	57723|Acidobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_609907_1	522306.CAP2UW1_0462	3.04e-75	245.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,1KPPI@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_314297_1	62928.azo3375	7.22e-33	130.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,2KUP6@206389|Rhodocyclales	206389|Rhodocyclales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_741158_1	443598.AUFA01000010_gene283	1.22e-87	264.0	COG0625@1|root,COG0625@2|Bacteria,1N8XH@1224|Proteobacteria,2TTHQ@28211|Alphaproteobacteria,3JSV2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	MA20_08585	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3
k59_577768_1	1072685.IX83_01775	7.11e-39	148.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,3T2I1@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_153000_1	1163617.SCD_n01627	2.85e-111	343.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_577773_1	1163409.UUA_16563	9.69e-47	168.0	COG1257@1|root,COG1577@1|root,COG1257@2|Bacteria,COG1577@2|Bacteria,1MXVE@1224|Proteobacteria,1RS9R@1236|Gammaproteobacteria,1X8RF@135614|Xanthomonadales	135614|Xanthomonadales	I	Hydroxymethylglutaryl-coenzyme A reductase	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,HMG-CoA_red
k59_153003_1	1112217.PPL19_22754	5.85e-05	49.3	COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_153003_2	1085623.GNIT_3307	2.74e-22	95.5	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,46508@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_120372_1	1123073.KB899241_gene3309	6.78e-10	63.2	COG3266@1|root,COG3266@2|Bacteria,1QYJ8@1224|Proteobacteria	1224|Proteobacteria	D	nuclear chromosome segregation	fimV_2	-	-	-	-	-	-	-	-	-	-	-	FecR
k59_969667_1	977880.RALTA_A0072	3.91e-25	108.0	COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,1K488@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM VanZ family protein	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
k59_937014_1	395494.Galf_0303	5.22e-28	110.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,44VMH@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_937014_2	477184.KYC_26217	2.39e-115	338.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,3T22A@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_708775_1	396595.TK90_1379	1.02e-51	176.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales	135613|Chromatiales	C	PFAM Alcohol dehydrogenase	-	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_902228_1	296591.Bpro_3898	8.04e-26	107.0	COG2199@1|root,COG2203@1|root,COG4251@1|root,COG5002@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1R7HC@1224|Proteobacteria,2WHFW@28216|Betaproteobacteria,4AJWX@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_902228_3	1437824.BN940_15546	9.03e-26	105.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,3T2I4@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_475432_1	330214.NIDE3266	8.08e-122	369.0	COG3808@1|root,COG3808@2|Bacteria	2|Bacteria	C	hydrogen-translocating pyrophosphatase activity	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_609941_1	1499967.BAYZ01000068_gene1939	8.4e-31	124.0	COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K02484,ko:K07636,ko:K07768	ko02020,map02020	M00434,M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
k59_535080_1	566466.NOR53_52	1.08e-84	260.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,1RNUH@1236|Gammaproteobacteria,1J7FF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yejE	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
k59_839345_1	671143.DAMO_0407	3.62e-66	220.0	COG0531@1|root,COG0531@2|Bacteria,2NNZQ@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	ydaO	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_54517_1	1163617.SCD_n01820	1.23e-16	79.3	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2VP12@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_54517_2	522306.CAP2UW1_2102	4.83e-79	241.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VK0C@28216|Betaproteobacteria,1KR7F@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	dctR	-	-	ko:K11712	ko02020,map02020	-	-	-	ko00000,ko00001,ko02022	-	-	-	GerE,Response_reg
k59_54517_3	640081.Dsui_3159	9.41e-26	105.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,2KUUR@206389|Rhodocyclales	206389|Rhodocyclales	T	Signal transduction histidine kinase	dctS	-	2.7.13.3	ko:K11711	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
k59_185178_1	94624.Bpet4709	1.83e-35	138.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,3T20G@506|Alcaligenaceae	28216|Betaproteobacteria	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8
k59_314339_1	1002340.AFCF01000025_gene1121	1.3e-10	63.5	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,34EAR@302485|Phaeobacter	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	MA20_24090	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH,TsaE
k59_314339_2	866774.HMPREF9248_0110	1.61e-26	109.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4CUGN@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_839354_2	1236976.JCM16418_5007	7.52e-13	66.2	2EI5I@1|root,33BWX@2|Bacteria,1W0I2@1239|Firmicutes,4HYE0@91061|Bacilli,2715G@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_609957_1	1266925.JHVX01000001_gene2629	3.68e-92	297.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	AMP-dependent synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_902251_1	998674.ATTE01000001_gene1799	1.43e-11	69.7	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RRZM@1236|Gammaproteobacteria,463RS@72273|Thiotrichales	72273|Thiotrichales	P	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,SCO1-SenC
k59_769532_1	1268072.PSAB_02965	3.4e-25	109.0	COG4346@1|root,COG5650@1|root,COG4346@2|Bacteria,COG5650@2|Bacteria,1TSHX@1239|Firmicutes,4ISHD@91061|Bacilli,26SCF@186822|Paenibacillaceae	91061|Bacilli	O	Glycosyl transferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	F5_F8_type_C,GT87,PMT,PMT_2,PMT_4TMC
k59_609961_1	1500257.JQNM01000004_gene173	2.72e-39	148.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR1S@28211|Alphaproteobacteria,4BAIH@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Single cache domain 3	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
k59_247158_1	749927.AMED_9142	1.99e-44	163.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4E0ZF@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_348586_1	1125700.HMPREF9195_01027	1.72e-71	232.0	COG1640@1|root,COG1640@2|Bacteria,2J5U4@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_380426_1	1286631.X805_04600	1.52e-91	289.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,1KJ8G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_937055_1	1121403.AUCV01000024_gene3424	1.28e-24	106.0	COG3875@1|root,COG3875@2|Bacteria,1RHU4@1224|Proteobacteria,42SM9@68525|delta/epsilon subdivisions,2WPUJ@28221|Deltaproteobacteria,2MKWW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_247166_1	472759.Nhal_1554	5e-36	137.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria,1X0HU@135613|Chromatiales	135613|Chromatiales	S	PFAM Tetratricopeptide TPR_4	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_247166_2	266834.SM_b20525	5.85e-06	48.5	COG1309@1|root,COG1309@2|Bacteria,1RBS8@1224|Proteobacteria,2U3P5@28211|Alphaproteobacteria,4BDPQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_937060_1	1231185.BAMP01000116_gene1495	2.61e-97	291.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,43KFS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_120433_1	5786.XP_003286863.1	1.47e-25	105.0	COG1612@1|root,KOG2725@2759|Eukaryota,3XE86@554915|Amoebozoa	554915|Amoebozoa	U	Cytochrome c oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_120433_2	1123360.thalar_02883	9.44e-13	63.2	2ERCE@1|root,33IY3@2|Bacteria,1NNN9@1224|Proteobacteria,2UXY5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_120433_3	596154.Alide2_3909	2.95e-83	249.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2VNRT@28216|Betaproteobacteria,4AGHP@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
k59_475476_1	1266925.JHVX01000011_gene1510	2.89e-77	257.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,3727S@32003|Nitrosomonadales	28216|Betaproteobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_870659_1	864051.BurJ1DRAFT_3625	7.64e-29	107.0	COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,2VSD5@28216|Betaproteobacteria,1KKTV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA	hscB	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,HSCB_C
k59_870659_2	987059.RBXJA2T_12617	1.7e-42	145.0	COG0454@1|root,COG0456@2|Bacteria,1RHB3@1224|Proteobacteria,2VSRV@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03829	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_7
k59_314375_2	1131812.JQMS01000001_gene1111	3.21e-10	62.0	COG1105@1|root,COG1105@2|Bacteria,4NFZI@976|Bacteroidetes,1HZBB@117743|Flavobacteriia,2NU68@237|Flavobacterium	976|Bacteroidetes	G	Belongs to the carbohydrate kinase PfkB family	pfkB	-	2.7.1.11,2.7.1.144	ko:K00917,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_791539_1	330214.NIDE1648	2.07e-88	276.0	COG3014@1|root,COG3014@2|Bacteria,3J14B@40117|Nitrospirae	40117|Nitrospirae	S	protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	-
k59_380448_1	1444306.JFZC01000031_gene2717	1.08e-28	112.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,26PHK@186821|Sporolactobacillaceae	91061|Bacilli	C	Transketolase, pyrimidine binding domain	acoB	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_380448_2	1313172.YM304_08490	9.94e-10	59.3	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria	201174|Actinobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	acoC	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_445870_1	596153.Alide_1608	8.96e-05	44.3	COG3181@1|root,COG3181@2|Bacteria,1NQBH@1224|Proteobacteria,2VN1G@28216|Betaproteobacteria,4ABVS@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_445870_2	1460634.JCM19037_3367	5.91e-07	55.1	COG2079@1|root,COG2079@2|Bacteria,1TSD7@1239|Firmicutes,4HEZJ@91061|Bacilli	91061|Bacilli	S	protein involved in propionate catabolism	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_577851_1	316067.Geob_2246	1.05e-14	82.0	COG0834@1|root,COG4191@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZV@68525|delta/epsilon subdivisions,2WMI3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Extracellular solute-binding protein, family 3	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SBP_bac_3
k59_217724_2	706587.Desti_0848	1.8e-38	135.0	COG0745@1|root,COG0745@2|Bacteria,1MZPD@1224|Proteobacteria,42U2Y@68525|delta/epsilon subdivisions,2WQ1I@28221|Deltaproteobacteria,2MRWP@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Usp
k59_839402_2	1454004.AW11_02856	2.99e-25	96.7	2EDYZ@1|root,337TS@2|Bacteria,1N7SA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_839402_3	1238182.C882_4245	2.01e-80	254.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,2JR9F@204441|Rhodospirillales	204441|Rhodospirillales	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_153080_1	240015.ACP_2236	2.03e-41	157.0	COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JKIF@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_1022831_1	522306.CAP2UW1_2720	1.02e-84	266.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2VHGJ@28216|Betaproteobacteria,1KQ62@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	fad dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Amino_oxidase,Pyr_redox_2
k59_54564_1	267608.RSc2635	9.85e-115	348.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,1K3HS@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_937084_1	335543.Sfum_3396	1.38e-24	98.6	COG0410@1|root,COG0410@2|Bacteria,1PFBJ@1224|Proteobacteria,42ZBI@68525|delta/epsilon subdivisions,2WUAI@28221|Deltaproteobacteria,2MRM9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_937084_2	1357272.AVEO02000199_gene138	1.21e-38	147.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,1RQU2@1236|Gammaproteobacteria,1Z5XF@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	E	amino acid ABC transporter, ATP-binding protein	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_741256_1	489825.LYNGBM3L_10620	7.53e-25	105.0	COG3315@1|root,COG3315@2|Bacteria,1G5DY@1117|Cyanobacteria,1HFS2@1150|Oscillatoriales	1117|Cyanobacteria	H	Leucine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCM
k59_217725_1	391735.Veis_4099	3e-06	48.9	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,4A9UR@80864|Comamonadaceae	28216|Betaproteobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_217725_2	614083.AWQR01000001_gene3114	4.64e-78	246.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,4ACGH@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_475485_1	596154.Alide2_3872	6.73e-70	227.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,2VJJ3@28216|Betaproteobacteria,4AAA4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_1000985_1	1123355.JHYO01000017_gene3631	6.23e-22	97.8	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,371BX@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim,Reductase_C,Rieske
k59_1000985_2	335543.Sfum_1080	4.92e-06	48.5	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42Q3E@68525|delta/epsilon subdivisions,2WJCW@28221|Deltaproteobacteria,2MQV4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_120455_1	1229909.NSED_06160	1.82e-63	197.0	COG1321@1|root,arCOG02100@2157|Archaea,41SQ9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
k59_902303_1	1502851.FG93_02679	1.93e-103	305.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,3JT90@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Protocatechuate 3,4-dioxygenase beta subunit N terminal	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
k59_676050_1	436308.Nmar_0886	1.68e-148	432.0	COG0129@1|root,arCOG04045@2157|Archaea,41SD0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_445881_1	196367.JNFG01000002_gene2142	2.04e-42	145.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,2WA27@28216|Betaproteobacteria,1K89J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_708862_1	1082931.KKY_2146	1.79e-56	193.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3N860@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_709722_2	487796.Flav2ADRAFT_1528	6.54e-18	79.3	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	-	-	-	-	-	-	-	-	-	STAS
k59_349409_1	1267005.KB911257_gene937	1.25e-58	198.0	COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,2U0IJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2,Sulfate_transp
k59_247888_2	1095769.CAHF01000006_gene1704	5.07e-77	253.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,2VHM3@28216|Betaproteobacteria,4756U@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Phospholipase D Active site motif	-	-	3.1.4.4	ko:K01115	ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231	-	R01310,R02051,R07385	RC00017,RC00425	ko00000,ko00001,ko01000,ko04131	-	-	-	PLDc,PLDc_2,SNARE_assoc
k59_121259_2	404589.Anae109_4242	6.81e-11	62.8	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales	28221|Deltaproteobacteria	K	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat
k59_513410_1	1255043.TVNIR_1179	8.43e-72	227.0	COG1335@1|root,COG1335@2|Bacteria,1RCGZ@1224|Proteobacteria,1SPB0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_970602_1	945713.IALB_3203	3.98e-59	210.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_578732_1	1046724.KB889894_gene3134	2.31e-75	231.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_770333_1	1079986.JH164837_gene5557	6.51e-30	120.0	COG3250@1|root,COG3250@2|Bacteria,2IF23@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 2	-	-	-	-	-	-	-	-	-	-	-	-	Bgal_small_N,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1001739_1	751994.AGIG01000034_gene615	6.4e-82	265.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1J9VK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.2.5.3,1.3.99.8	ko:K03520,ko:K16877,ko:K20171	ko00365,ko00760,ko01120,map00365,map00760,map01120	M00811	R02987,R11168,R11179	RC00589,RC01856,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,COXG
k59_791865_1	1123274.KB899440_gene698	1.41e-59	206.0	COG0243@1|root,COG0243@2|Bacteria,2J9ZG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3	ko:K07306	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3	-	-	Molybdopterin,Molydop_binding,Nitrate_red_del
k59_411206_1	330214.NIDE1705	1.75e-151	435.0	COG0468@1|root,COG0468@2|Bacteria,3J0C1@40117|Nitrospirae	40117|Nitrospirae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_977262_1	261292.Nit79A3_2700	2.85e-29	107.0	COG1531@1|root,COG1531@2|Bacteria,1N7PM@1224|Proteobacteria,2W6WU@28216|Betaproteobacteria,374JG@32003|Nitrosomonadales	28216|Betaproteobacteria	AJ	Protein of unknown function (DUF504)	-	-	-	-	-	-	-	-	-	-	-	-	DUF504
k59_877668_1	1123368.AUIS01000014_gene2294	4.47e-105	317.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,2NBZH@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Putative modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_846947_1	395493.BegalDRAFT_1910	7.48e-26	106.0	COG0517@1|root,COG0538@1|root,COG0517@2|Bacteria,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Isocitrate dehydrogenase	icd	GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144	Iso_dh
k59_452768_1	1267534.KB906759_gene2005	8.35e-54	181.0	COG0524@1|root,COG0524@2|Bacteria,3Y3GE@57723|Acidobacteria,2JHP7@204432|Acidobacteriia	204432|Acidobacteriia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
k59_944435_1	640081.Dsui_0462	1.52e-07	56.6	COG0859@1|root,COG0859@2|Bacteria,1NEWM@1224|Proteobacteria,2VQ5K@28216|Betaproteobacteria,2KYIU@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
k59_716245_1	338969.Rfer_2918	2.05e-101	317.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,4AA8D@80864|Comamonadaceae	28216|Betaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_387167_1	945713.IALB_3150	7.1e-69	217.0	COG0568@1|root,COG0568@2|Bacteria	2|Bacteria	K	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_617088_1	1131553.JIBI01000046_gene1600	8.13e-90	280.0	COG2855@1|root,COG2855@2|Bacteria	2|Bacteria	P	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_481657_1	927677.ALVU02000008_gene17	5.83e-154	446.0	COG0119@1|root,COG0119@2|Bacteria,1G0JT@1117|Cyanobacteria,1H4RI@1142|Synechocystis	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS10690,iYO844.BSU28280	HMGL-like,LeuA_dimer
k59_748764_1	1229205.BUPH_04319	4.26e-99	300.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,1K1XC@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_877683_1	247634.GPB2148_2347	3.58e-109	317.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1J679@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_29929_1	335541.Swol_0376	1.41e-75	242.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,42KEK@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_617095_1	1501391.LG35_00040	2.41e-21	97.4	COG2365@1|root,COG2365@2|Bacteria,4NGPX@976|Bacteroidetes,2FWH1@200643|Bacteroidia	976|Bacteroidetes	T	Tyrosine phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
k59_29931_1	96561.Dole_2657	1.02e-63	218.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_776073_1	1380391.JIAS01000017_gene610	9.78e-20	93.2	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria,2JPR6@204441|Rhodospirillales	204441|Rhodospirillales	H	Probable molybdopterin binding domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_61516_1	765911.Thivi_2859	9.89e-74	232.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_387180_2	1114964.L485_17130	1.09e-55	187.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_649394_2	272560.BPSL2446	1.49e-26	103.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2VQUQ@28216|Betaproteobacteria,1K0CJ@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Maf-like protein	yceF	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_481669_1	228410.NE1766	2.71e-165	481.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,371N6@32003|Nitrosomonadales	28216|Betaproteobacteria	C	chain 5 L	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_29944_1	439235.Dalk_3901	6.43e-95	301.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MJ0S@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_61526_1	158500.BV97_00919	2.88e-57	200.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2K05M@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_160193_1	344747.PM8797T_24796	4.55e-21	94.0	COG1409@1|root,COG1409@2|Bacteria,2J1WA@203682|Planctomycetes	203682|Planctomycetes	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_192290_1	1131553.JIBI01000048_gene1032	1.66e-10	63.2	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,371N8@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Acts as a magnesium transporter	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE,MgtE_N
k59_977305_1	380703.AHA_2697	1.96e-18	90.9	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1Y5TP@135624|Aeromonadales	135624|Aeromonadales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k59_355874_1	1294142.CINTURNW_0307	3.41e-17	89.0	2DZCS@1|root,32V7E@2|Bacteria,1VKR3@1239|Firmicutes,25FV9@186801|Clostridia,36UZP@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_683569_1	767434.Fraau_2609	6.06e-98	313.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1X47W@135614|Xanthomonadales	135614|Xanthomonadales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_452806_2	420662.Mpe_A0795	6.92e-48	166.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1KN4H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_224688_1	436308.Nmar_0809	1.83e-67	213.0	COG0087@1|root,arCOG04070@2157|Archaea,41SDN@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein L3	-	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_847001_1	257310.BB3191	7.24e-245	700.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,3T1WD@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_95693_1	1485544.JQKP01000012_gene2177	1.5e-34	126.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,44VKK@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1732)	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_95693_2	1163617.SCD_n00513	5.57e-65	204.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2VPCK@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_683598_1	1123072.AUDH01000025_gene345	8.41e-29	110.0	COG0596@1|root,COG0596@2|Bacteria,1NJ2B@1224|Proteobacteria,2TR54@28211|Alphaproteobacteria,2JV21@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_683598_2	426355.Mrad2831_3372	1.31e-25	103.0	COG0596@1|root,COG0596@2|Bacteria,1NJ2B@1224|Proteobacteria,2TR54@28211|Alphaproteobacteria,1JS40@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_585508_1	338969.Rfer_4083	5.07e-10	65.5	COG3303@1|root,COG3303@2|Bacteria,1R8WP@1224|Proteobacteria,2VZZU@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_452836_1	420662.Mpe_A3296	6.03e-76	236.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1KJ0U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_224714_2	497321.C664_00585	9.71e-103	306.0	COG5501@1|root,COG5501@2|Bacteria,1PB0I@1224|Proteobacteria,2VNJJ@28216|Betaproteobacteria,2KW2T@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulphur oxidation protein SoxZ	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ
k59_387229_1	1242864.D187_000226	5.25e-52	186.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,438D9@68525|delta/epsilon subdivisions,2X3NF@28221|Deltaproteobacteria,2YWN6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_320985_1	317655.Sala_2339	2.12e-23	92.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2U9NV@28211|Alphaproteobacteria,2K5VY@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
k59_320985_2	1101189.AQUO01000001_gene1593	5.66e-46	158.0	COG0394@1|root,COG1393@1|root,COG0394@2|Bacteria,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2U70U@28211|Alphaproteobacteria,2PZ6S@265|Paracoccus	28211|Alphaproteobacteria	PT	ArsC family	arsC	-	1.20.4.1	ko:K00537,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	ArsC,LMWPc
k59_538899_1	1236959.BAMT01000008_gene2466	6.76e-41	141.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,2KMN7@206350|Nitrosomonadales	206350|Nitrosomonadales	O	PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_281487_2	246196.MSMEI_2014	5.97e-20	89.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,2332U@1762|Mycobacteriaceae	201174|Actinobacteria	C	NADH dehydrogenase	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_617156_1	1521187.JPIM01000073_gene2792	1.58e-34	131.0	COG3547@1|root,COG3547@2|Bacteria,2G9MR@200795|Chloroflexi	200795|Chloroflexi	L	SPTR B7KVZ8 Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_224722_1	491915.Aflv_0159	1.53e-33	133.0	COG1943@1|root,COG3599@1|root,COG1943@2|Bacteria,COG3599@2|Bacteria,1TRNH@1239|Firmicutes,4HHNJ@91061|Bacilli,21WUY@150247|Anoxybacillus	91061|Bacilli	D	Transposase	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_585523_1	272560.BPSL3419	1.85e-88	276.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1K2NR@119060|Burkholderiaceae	28216|Betaproteobacteria	E	(GMC) oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_481720_1	323848.Nmul_A1402	3.35e-51	185.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_61588_1	396588.Tgr7_0842	1.05e-71	230.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_977365_1	1121875.KB907547_gene2908	1.9e-17	88.6	COG0834@1|root,COG2172@1|root,COG2208@1|root,COG3829@1|root,COG0834@2|Bacteria,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3829@2|Bacteria,4PPGD@976|Bacteroidetes	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_452858_1	1454004.AW11_01626	1.28e-32	122.0	COG4970@1|root,COG4970@2|Bacteria,1NA9B@1224|Proteobacteria,2VWAB@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type II transport protein GspH	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_452858_2	1485544.JQKP01000002_gene1379	2.43e-13	66.6	COG4967@1|root,COG4967@2|Bacteria,1N7AC@1224|Proteobacteria,2VW8B@28216|Betaproteobacteria,44W3Z@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	type IV pilus modification protein PilV	-	-	-	ko:K02671	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
k59_847037_1	396588.Tgr7_2963	1.09e-80	251.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1WW8U@135613|Chromatiales	135613|Chromatiales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_649466_1	887062.HGR_06486	4.21e-89	270.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,4AAEE@80864|Comamonadaceae	28216|Betaproteobacteria	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_453738_1	1121405.dsmv_3243	9.48e-89	266.0	COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,42Q82@68525|delta/epsilon subdivisions,2WMBU@28221|Deltaproteobacteria,2MI8W@213118|Desulfobacterales	28221|Deltaproteobacteria	E	phosphoserine phosphatase homoserine phosphotransferase bifunctional protein	-	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD
k59_776999_1	1163617.SCD_n00375	1.51e-15	72.8	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2VR9X@28216|Betaproteobacteria	28216|Betaproteobacteria	K	transcriptional regulator AsnC family	nirH	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_776999_2	1121035.AUCH01000016_gene2124	5.07e-60	195.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,2KUGV@206389|Rhodocyclales	206389|Rhodocyclales	C	radical SAM protein	nirJ	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_1027145_1	1131553.JIBI01000004_gene422	1.81e-61	201.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2VH5S@28216|Betaproteobacteria,3720W@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_453744_1	987059.RBXJA2T_16907	2.06e-110	329.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1KJX9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_945544_1	945713.IALB_0015	3.13e-103	328.0	COG1197@1|root,COG1197@2|Bacteria	2|Bacteria	L	transcription-coupled nucleotide-excision repair, DNA damage recognition	mfd	-	2.4.1.129,3.4.16.4	ko:K03723,ko:K05365	ko00550,ko03420,map00550,map03420	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011,ko03400	-	GT51	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_254429_2	395492.Rleg2_1002	4.21e-19	86.3	COG3293@1|root,COG3293@2|Bacteria,1REX3@1224|Proteobacteria,2U89Y@28211|Alphaproteobacteria,4BM8S@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_586496_1	1131553.JIBI01000042_gene2002	3.6e-44	157.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2WEJB@28216|Betaproteobacteria,37412@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Domain of unknown function (DUF3391)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD_5
k59_225658_1	1411123.JQNH01000001_gene924	4.83e-63	207.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system large permease component	MA20_17100	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_161180_1	987059.RBXJA2T_16457	1.68e-24	102.0	COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,2VS9P@28216|Betaproteobacteria,1KK5C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	PFAM General secretion pathway protein K	gspK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
k59_282036_1	1444310.JANV01000115_gene4517	2.68e-39	132.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,1ZHWN@1386|Bacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_282036_2	330214.NIDE1333	8.9e-55	177.0	COG0024@1|root,COG0024@2|Bacteria,3J0GR@40117|Nitrospirae	40117|Nitrospirae	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_910171_2	330214.NIDE0352	3.23e-30	119.0	COG0308@1|root,COG0308@2|Bacteria,3J0Y4@40117|Nitrospirae	40117|Nitrospirae	E	Peptidase family M1 domain	-	-	-	ko:K08776	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_161181_1	768671.ThimaDRAFT_4426	1.74e-76	244.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria,1SQA0@1236|Gammaproteobacteria,1X16W@135613|Chromatiales	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_30945_2	1380391.JIAS01000011_gene5474	5.79e-11	65.9	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,2TRM3@28211|Alphaproteobacteria,2JVTS@204441|Rhodospirillales	204441|Rhodospirillales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_1008892_1	1370122.JHXQ01000002_gene2852	1.51e-45	157.0	COG3385@1|root,COG3385@2|Bacteria,1R8M9@1224|Proteobacteria,2UI32@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_321835_1	246197.MXAN_5837	5.23e-13	73.9	COG4932@1|root,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,438GF@68525|delta/epsilon subdivisions,2X3RA@28221|Deltaproteobacteria,2YWWZ@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial Ig-like domain (group 1)	-	-	-	-	-	-	-	-	-	-	-	-	Big_1,LTD
k59_945560_2	1120999.JONM01000001_gene1061	5.13e-12	63.5	COG0400@1|root,COG0400@2|Bacteria,1REBB@1224|Proteobacteria,2VR9J@28216|Betaproteobacteria,2KTFW@206351|Neisseriales	206351|Neisseriales	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_749886_1	349521.HCH_01828	4.44e-13	73.6	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,1RRI8@1236|Gammaproteobacteria,1XM25@135619|Oceanospirillales	135619|Oceanospirillales	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_254455_1	1121013.P873_14190	3.34e-64	205.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,1X5FC@135614|Xanthomonadales	135614|Xanthomonadales	S	Extradiol ring-cleavage dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
k59_1008906_1	1324957.K933_03445	5.07e-22	102.0	COG3119@1|root,arCOG02787@2157|Archaea,2XUWX@28890|Euryarchaeota,23S64@183963|Halobacteria	183963|Halobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1,3.1.6.6	ko:K01130,ko:K01133	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_684668_1	1129374.AJE_15994	1.11e-121	354.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria,46631@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	ylbG	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_2,rve_3
k59_951859_2	439235.Dalk_3864	2.35e-41	142.0	COG2050@1|root,COG2050@2|Bacteria,1PXW0@1224|Proteobacteria,434W2@68525|delta/epsilon subdivisions,2X91S@28221|Deltaproteobacteria,2MP36@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_429227_1	335543.Sfum_0443	5.59e-31	119.0	COG3218@1|root,COG3218@2|Bacteria,1QWQA@1224|Proteobacteria,42VJ7@68525|delta/epsilon subdivisions,2WS0Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
k59_429227_2	335543.Sfum_0445	1.77e-28	111.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WPA2@28221|Deltaproteobacteria,2MQIC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cytochrome b/b6/petB	cbcW	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrom_C,Cytochrome_B,Cytochrome_CBB3
k59_135812_1	330214.NIDE2857	4.09e-141	405.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_168402_1	1268622.AVS7_01244	1.66e-43	154.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,4AAPD@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_298587_1	795666.MW7_2836	7.79e-30	122.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,1K0ZW@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_495126_1	1116472.MGMO_125c00130	1.71e-48	161.0	COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1XEYA@135618|Methylococcales	135618|Methylococcales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
k59_495126_2	264198.Reut_A1341	9.29e-17	73.9	COG5570@1|root,COG5570@2|Bacteria,1R3J1@1224|Proteobacteria,2VXMA@28216|Betaproteobacteria,1K9K9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
k59_5166_1	1278309.KB907099_gene2933	2.08e-65	214.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1QYEW@1224|Proteobacteria,1T3PI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Pyr_redox_3
k59_984215_1	1132855.KB913035_gene1434	1.07e-68	221.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,2KM2I@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_200954_1	246197.MXAN_3138	3.66e-10	67.0	COG2133@1|root,COG2133@2|Bacteria,1PER7@1224|Proteobacteria,4399G@68525|delta/epsilon subdivisions,2X4GV@28221|Deltaproteobacteria,2YYZS@29|Myxococcales	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_690953_1	383372.Rcas_2710	2.14e-71	228.0	COG0664@1|root,COG1136@1|root,COG0664@2|Bacteria,COG1136@2|Bacteria,2G6C9@200795|Chloroflexi,37685@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
k59_886109_1	580332.Slit_1626	1.19e-72	228.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria,44V3N@713636|Nitrosomonadales	28216|Betaproteobacteria	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_886109_2	335283.Neut_2041	5.91e-92	277.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2VHAM@28216|Betaproteobacteria,3728V@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_886109_3	935848.JAEN01000002_gene995	9.68e-22	95.5	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria,2PUHQ@265|Paracoccus	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1223)	MA20_43790	-	-	-	-	-	-	-	-	-	-	-	DUF1223
k59_658351_1	1205680.CAKO01000038_gene1779	1.37e-45	160.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,2JRIA@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_658351_2	1207063.P24_13383	2.24e-72	229.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VGB7@28211|Alphaproteobacteria,2JYRY@204441|Rhodospirillales	204441|Rhodospirillales	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_560351_1	1201293.AKXQ01000022_gene428	4.85e-61	210.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_560351_2	1131451.O1K_09137	8.39e-12	64.7	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1X3DQ@135614|Xanthomonadales	135614|Xanthomonadales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
k59_135850_2	987059.RBXJA2T_02230	7.11e-17	72.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,2VXPQ@28216|Betaproteobacteria,1KMSK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
k59_135850_3	94122.Shewana3_0221	8.34e-21	85.5	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,2QBVP@267890|Shewanellaceae	1236|Gammaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_560352_1	977880.RALTA_B0210	6.27e-59	195.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6UF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_37826_1	714943.Mucpa_4501	5.11e-10	66.6	COG1502@1|root,COG1502@2|Bacteria,4NE2W@976|Bacteroidetes,1IQ27@117747|Sphingobacteriia	976|Bacteroidetes	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_951906_2	331869.BAL199_20375	4.06e-09	59.3	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TTJV@28211|Alphaproteobacteria,4BP8F@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	gyaR1	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_560355_1	479434.Sthe_0452	4.49e-25	115.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_592833_1	999541.bgla_1g08110	8.01e-52	179.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2VI67@28216|Betaproteobacteria,1JZSQ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	transferase	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
k59_364022_1	1292020.H483_0117340	3.25e-53	182.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_919513_1	658187.LDG_6739	1.51e-19	88.6	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RPFX@1236|Gammaproteobacteria,1JEJS@118969|Legionellales	118969|Legionellales	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_919513_2	1159870.KB907784_gene2780	7.23e-22	94.0	COG0451@1|root,COG0451@2|Bacteria,1MV73@1224|Proteobacteria,2VI84@28216|Betaproteobacteria	28216|Betaproteobacteria	M	CDP-glucose 4,6-dehydratase	rfbG	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_886128_1	288000.BBta_4075	4.65e-27	110.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,3JX83@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_886128_2	1298880.AUEV01000015_gene53	3.44e-94	290.0	COG0620@1|root,COG0620@2|Bacteria,2I9RI@201174|Actinobacteria	201174|Actinobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_821574_1	866895.HBHAL_2134	3.71e-73	235.0	COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria,1TQAZ@1239|Firmicutes,4HCQW@91061|Bacilli,3NFQW@45667|Halobacillus	91061|Bacilli	K	Carbon-nitrogen hydrolase	yhcX	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_723515_1	1123229.AUBC01000028_gene2290	3.79e-58	201.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JSZE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_70686_1	1232410.KI421422_gene2049	3.5e-95	291.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,43S0H@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_364040_1	1116472.MGMO_97c00300	7.64e-06	47.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1XE5F@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_38827_1	1396418.BATQ01000189_gene762	2.84e-82	258.0	COG3344@1|root,COG3344@2|Bacteria,46TQ6@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_6242_1	1397528.Q671_08955	2.23e-88	270.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1XHYS@135619|Oceanospirillales	135619|Oceanospirillales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_887067_1	1163617.SCD_n02448	2.83e-152	446.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria	28216|Betaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_920538_1	580332.Slit_0154	2.51e-79	249.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,2W9S9@28216|Betaproteobacteria,44WN9@713636|Nitrosomonadales	28216|Betaproteobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR
k59_169461_1	1041138.KB890256_gene3547	4.65e-11	68.2	COG0747@1|root,COG0747@2|Bacteria,1R410@1224|Proteobacteria,2TUWI@28211|Alphaproteobacteria,4B8WE@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_430282_1	1229909.NSED_02135	6.17e-34	119.0	arCOG08665@1|root,arCOG08665@2157|Archaea	2157|Archaea	S	Haem utilisation ChuX/HutX	-	-	-	-	-	-	-	-	-	-	-	-	ChuX_HutX
k59_430282_2	1229909.NSED_02130	1.86e-37	127.0	arCOG08666@1|root,arCOG08666@2157|Archaea,41SVR@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_724518_1	436308.Nmar_0341	2.56e-87	268.0	COG1104@1|root,arCOG00066@2157|Archaea,41SB1@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_920547_1	266779.Meso_0340	1.54e-37	144.0	COG0642@1|root,COG0784@1|root,COG4192@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG4192@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,dCache_1
k59_332597_1	1123034.JMKP01000017_gene146	3.28e-20	89.7	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3NJ99@468|Moraxellaceae	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_38845_1	1352941.M877_35135	6.68e-06	52.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria	201174|Actinobacteria	T	(FHA) domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
k59_267381_2	305700.B447_15351	3.29e-43	145.0	COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,2VSEG@28216|Betaproteobacteria,2KWKD@206389|Rhodocyclales	206389|Rhodocyclales	C	COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_496195_1	1266925.JHVX01000001_gene2525	1.64e-09	57.4	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,2VRF6@28216|Betaproteobacteria,372V7@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
k59_496195_2	287.DR97_2242	1.62e-38	135.0	COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,1S6R9@1236|Gammaproteobacteria,1YDZ7@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	O	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly	ureE	-	-	ko:K03187	-	-	-	-	ko00000	-	-	-	UreE_C,UreE_N
k59_593880_1	204773.HEAR0348	1.72e-103	308.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,4765G@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_920553_1	1049564.TevJSym_ao00730	2.18e-50	166.0	COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1J73I@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
k59_71742_1	665956.HMPREF1032_03801	7.01e-15	79.7	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V48A@1239|Firmicutes,24GUP@186801|Clostridia,3WRJR@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
k59_561389_1	1123504.JQKD01000026_gene4321	6.06e-10	59.3	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2VICF@28216|Betaproteobacteria,4AAP2@80864|Comamonadaceae	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	ugpE	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
k59_561389_2	388051.AUFE01000009_gene1797	2.77e-75	233.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2VH0I@28216|Betaproteobacteria,1K1RU@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	ugpA	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
k59_985252_1	225937.HP15_1322	2.87e-52	173.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_985252_2	1304275.C41B8_17868	3.92e-58	192.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_332604_1	485913.Krac_3951	6.48e-83	260.0	COG3666@1|root,COG3666@2|Bacteria,2G998@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_267394_1	1125863.JAFN01000001_gene2828	9.84e-21	90.5	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43AW1@68525|delta/epsilon subdivisions,2X6A7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_397019_1	882.DVU_0702	1.43e-15	77.4	COG0737@1|root,COG0737@2|Bacteria,1NDBC@1224|Proteobacteria,42V2W@68525|delta/epsilon subdivisions,2X5T9@28221|Deltaproteobacteria,2MBXJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_755945_1	1217718.ALOU01000040_gene149	5.02e-102	305.0	COG3181@1|root,COG3181@2|Bacteria,1MYJX@1224|Proteobacteria,2VKS4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_233766_1	754477.Q7C_1684	2.2e-47	164.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,4601D@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_953002_1	991905.SL003B_1365	4.36e-40	139.0	COG0824@1|root,COG0824@2|Bacteria,1MZB3@1224|Proteobacteria,2U7CU@28211|Alphaproteobacteria,4BS6R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
k59_659429_1	161528.ED21_17652	7.21e-66	201.0	COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2UC5K@28211|Alphaproteobacteria,2K4NE@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_659429_2	161528.ED21_17647	4.69e-61	195.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,2KD0W@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_985272_1	987059.RBXJA2T_14421	7.53e-73	219.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,1KKSP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Required for insertion of 4Fe-4S clusters	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_985272_2	864051.BurJ1DRAFT_1068	6.52e-30	109.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2VTZQ@28216|Betaproteobacteria,1KM73@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Polymer-forming cytoskeletal	ccmA	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_626421_1	62928.azo0389	2.52e-122	367.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KV59@206389|Rhodocyclales	206389|Rhodocyclales	I	poly(R)-hydroxyalkanoic acid synthase	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_692041_1	977880.RALTA_B1144	9.2e-60	202.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VPPU@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1014723_1	768671.ThimaDRAFT_0867	2.23e-89	273.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1S0WJ@1236|Gammaproteobacteria,1WWFB@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
k59_136906_1	335283.Neut_0779	7.65e-51	174.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,37215@32003|Nitrosomonadales	28216|Betaproteobacteria	I	fatty acid desaturase	ole1	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_136906_2	883126.HMPREF9710_01799	1.29e-24	92.8	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2VVW8@28216|Betaproteobacteria,47532@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_469603_1	323848.Nmul_A1753	3.14e-87	264.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,372AJ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_668906_1	1454004.AW11_02703	1.4e-104	316.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2VPY3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_274167_1	1123488.ATUF01000002_gene532	1.64e-11	67.4	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4D32W@85005|Actinomycetales	201174|Actinobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_274167_2	525897.Dbac_1226	8.64e-05	44.7	COG2204@1|root,COG2204@2|Bacteria,1MWW5@1224|Proteobacteria,42PBX@68525|delta/epsilon subdivisions,2WJY3@28221|Deltaproteobacteria,2M7YD@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Sigma54_activat
k59_863740_1	1089550.ATTH01000001_gene407	2.39e-43	164.0	COG0466@1|root,COG0466@2|Bacteria,4NE1G@976|Bacteroidetes,1FJX3@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Found in ATP-dependent protease La (LON)	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_15796_1	998674.ATTE01000001_gene675	4.38e-78	256.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,4605Q@72273|Thiotrichales	72273|Thiotrichales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_113462_1	1121033.AUCF01000003_gene3500	1.46e-59	194.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,2TVNY@28211|Alphaproteobacteria,2JS9Y@204441|Rhodospirillales	204441|Rhodospirillales	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
k59_113462_2	76114.ebB133	1.25e-67	208.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2VR6I@28216|Betaproteobacteria,2KWG3@206389|Rhodocyclales	206389|Rhodocyclales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_113462_3	323848.Nmul_A0792	3.9e-186	523.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,372HG@32003|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_668912_1	1268072.PSAB_23715	9.25e-39	143.0	COG4134@1|root,COG4134@2|Bacteria	2|Bacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
k59_241223_1	948106.AWZT01000041_gene3776	4.08e-13	68.6	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2VN4F@28216|Betaproteobacteria,1K2KT@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Dehydrogenase	-	-	1.2.5.3,1.3.99.8	ko:K03519,ko:K16878	ko00365,ko01120,map00365,map01120	-	R02987,R11168	RC01856,RC02800	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_241223_2	1265310.CCBD010000023_gene4290	1.36e-18	85.9	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.14.14.12	ko:K16047	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R09819	RC00236	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
k59_178704_2	1217656.F964_04417	2e-27	110.0	COG2995@1|root,COG2995@2|Bacteria,1RAQ9@1224|Proteobacteria,1SBDT@1236|Gammaproteobacteria,3NJG9@468|Moraxellaceae	1236|Gammaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_439201_1	335659.S23_55160	8.59e-49	169.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,3JRNY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_863760_1	1122176.KB903557_gene4036	3.21e-101	303.0	COG1960@1|root,COG1960@2|Bacteria,4NEKJ@976|Bacteroidetes,1INZ7@117747|Sphingobacteriia	976|Bacteroidetes	I	acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_146161_1	1121875.KB907552_gene313	2.79e-64	216.0	COG1082@1|root,COG1082@2|Bacteria,4NEWC@976|Bacteroidetes,1HY05@117743|Flavobacteriia	976|Bacteroidetes	G	Alpha-glucosidase	-	-	3.2.1.20,3.2.1.3	ko:K01187,ko:K21574	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01790,R01791,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31,GH97	-	GH97_C,GH97_N,Glyco_hydro_97
k59_930039_2	1265505.ATUG01000003_gene897	1.42e-09	63.9	COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria,2MPNG@213118|Desulfobacterales	28221|Deltaproteobacteria	G	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_373941_1	1207076.ALAT01000011_gene1427	3.05e-74	239.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1Z08F@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	COG0277 FAD FMN-containing dehydrogenases	IV02_25675	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_832283_1	796942.HMPREF9623_01278	1.38e-06	52.4	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,2492D@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_832283_2	1298880.AUEV01000002_gene1402	5.4e-12	68.9	COG2303@1|root,COG2303@2|Bacteria,2GNHC@201174|Actinobacteria	201174|Actinobacteria	E	glucose-methanol-choline oxidoreductase	-	-	1.1.1.400	ko:K20927,ko:K21166	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_603120_2	1381751.JAJB01000018_gene2389	0.000629	43.9	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4FAPM@85019|Brevibacteriaceae	201174|Actinobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	1.1.1.100,1.1.1.304,1.1.1.76	ko:K00059,ko:K03366	ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R02855,R02946,R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R11671	RC00029,RC00117,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_865036_2	357808.RoseRS_3693	3.73e-05	47.0	COG4770@1|root,COG4770@2|Bacteria,2GBMU@200795|Chloroflexi,3782K@32061|Chloroflexia	32061|Chloroflexia	I	PFAM biotin lipoyl attachment domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
k59_242295_1	866895.HBHAL_1800	7.79e-11	61.6	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,3NDI9@45667|Halobacillus	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_242295_2	1382304.JNIL01000001_gene980	3.43e-46	162.0	COG1960@1|root,COG1960@2|Bacteria,1TR1Y@1239|Firmicutes,4HC1N@91061|Bacilli	91061|Bacilli	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_343034_1	1121124.JNIX01000009_gene2670	1.26e-27	110.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U69N@28211|Alphaproteobacteria,2KH4R@204458|Caulobacterales	204458|Caulobacterales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
k59_147437_1	28258.KP05_03275	1.95e-08	53.9	COG0346@1|root,COG0346@2|Bacteria,1N7R0@1224|Proteobacteria,1SFI3@1236|Gammaproteobacteria,1XMMJ@135619|Oceanospirillales	135619|Oceanospirillales	E	Lactoylglutathione lyase and related lyases	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	-
k59_147437_3	1121035.AUCH01000017_gene2252	1.31e-60	199.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VK32@28216|Betaproteobacteria,2KZRT@206389|Rhodocyclales	206389|Rhodocyclales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_764597_1	265072.Mfla_1712	3.65e-11	68.9	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2VK90@28216|Betaproteobacteria,2KMF0@206350|Nitrosomonadales	206350|Nitrosomonadales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_931309_1	522306.CAP2UW1_2517	4.96e-94	293.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,1KQEU@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_931309_2	497321.C664_18417	9.16e-18	82.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,2KVVV@206389|Rhodocyclales	206389|Rhodocyclales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_995491_1	1528106.JRJE01000031_gene3363	3.12e-51	176.0	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria,2JQ7C@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_703054_1	1089553.Tph_c25410	8.02e-20	92.4	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales	186801|Clostridia	KLT	Serine threonine protein kinase	sps1	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_735423_2	1232437.KL661959_gene3094	1.83e-08	58.9	COG4565@1|root,COG4963@1|root,COG4565@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,2MJQA@213118|Desulfobacterales	28221|Deltaproteobacteria	D	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA,Response_reg
k59_1020163_1	1459636.NTE_01246	4.56e-16	75.1	COG1715@1|root,arCOG09740@2157|Archaea,41T5F@651137|Thaumarchaeota	651137|Thaumarchaeota	V	Domain of unknown function (DUF1802)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1802
k59_1020163_2	671143.DAMO_2491	1.82e-25	102.0	COG1028@1|root,COG1028@2|Bacteria,2NQBD@2323|unclassified Bacteria	2|Bacteria	IQ	NAD(P)H binding domain of trans-2-enoyl-CoA reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_343058_1	1123504.JQKD01000009_gene2226	3.26e-62	211.0	COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,2VK2M@28216|Betaproteobacteria,4AAN6@80864|Comamonadaceae	28216|Betaproteobacteria	O	AAA ATPase, central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_309298_1	1267005.KB911257_gene1120	2.18e-67	215.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,3N6HD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	etfA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_212277_1	580332.Slit_1446	1.22e-13	71.6	COG0492@1|root,COG0492@2|Bacteria,1R12A@1224|Proteobacteria,2WHYF@28216|Betaproteobacteria	28216|Betaproteobacteria	O	ferredoxin-NADP+ reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_212277_2	395495.Lcho_1541	1.07e-28	115.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2VPQ6@28216|Betaproteobacteria	28216|Betaproteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
k59_703067_2	335283.Neut_1127	2.07e-219	614.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria,3729N@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_343067_1	693986.MOC_1618	3.71e-41	148.0	COG0535@1|root,COG0535@2|Bacteria,1NJZV@1224|Proteobacteria,2U4H8@28211|Alphaproteobacteria,1JSDQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_764625_2	1267535.KB906767_gene1442	2.34e-38	130.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XM@57723|Acidobacteria,2JJHR@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_995513_1	247634.GPB2148_698	7.13e-43	146.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1J5J1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG0708 Exonuclease III	crc	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_995513_2	247634.GPB2148_713	5.16e-39	136.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1J4ME@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_833610_1	288000.BBta_7818	8.22e-79	236.0	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2UAE0@28211|Alphaproteobacteria,3K60B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
k59_833610_2	288000.BBta_7817	6.58e-39	130.0	COG3293@1|root,COG3293@2|Bacteria,1QWUV@1224|Proteobacteria,2TX63@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_17113_1	1121004.ATVC01000018_gene1930	7.81e-18	79.7	COG0386@1|root,COG0386@2|Bacteria,1RDR8@1224|Proteobacteria,2VQHV@28216|Betaproteobacteria,2KRA1@206351|Neisseriales	206351|Neisseriales	O	Glutathione peroxidase	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
k59_670229_1	627192.SLG_25570	4.49e-88	275.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,2K1S1@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_572116_1	78245.Xaut_3720	3.38e-20	87.8	COG0791@1|root,COG0791@2|Bacteria,1N732@1224|Proteobacteria,2UH6X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
k59_1020168_2	745411.B3C1_18794	1.47e-51	166.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1J67P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_274797_1	1123060.JONP01000012_gene2879	1.19e-24	97.1	COG0251@1|root,COG0251@2|Bacteria,1REJQ@1224|Proteobacteria	1224|Proteobacteria	J	Endoribonuclease L-PSP	MA20_01450	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_274797_2	1286631.X805_18720	3.08e-33	122.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,1KJNM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_309321_2	379066.GAU_3053	2.3e-46	160.0	COG4152@1|root,COG4152@2|Bacteria,1ZSSG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_49288_1	1126627.BAWE01000002_gene269	6.98e-66	213.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,3JRID@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Epoxide hydrolase N terminus	MA20_04980	-	-	ko:K21159	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	EHN
k59_703087_1	247490.KSU1_C1443	1.14e-29	120.0	COG1234@1|root,COG1234@2|Bacteria,2J27A@203682|Planctomycetes	203682|Planctomycetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_865104_1	766499.C357_08241	5.9e-57	201.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3321 Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
k59_274803_1	1121396.KB892901_gene2202	1.28e-48	175.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,42MPY@68525|delta/epsilon subdivisions,2WJ2V@28221|Deltaproteobacteria,2MJGM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	belongs to the CobB CobQ family	pta	-	2.3.1.8	ko:K00625,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1035	AAA_26,DRTGG,PTA_PTB
k59_897028_1	794903.OPIT5_01265	2.82e-25	105.0	COG3547@1|root,COG3547@2|Bacteria,46WNP@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_114798_1	864051.BurJ1DRAFT_2067	4.51e-79	247.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,1KMB7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_789210_1	570952.ATVH01000004_gene2586	1.31e-52	177.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,2JSGW@204441|Rhodospirillales	204441|Rhodospirillales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	ko:K22303	-	-	-	-	ko00000,ko01000	-	-	-	TauD
k59_764649_1	247634.GPB2148_498	3.97e-41	154.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,1S52W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_180010_1	1246626.BleG1_3352	2.56e-48	159.0	COG0454@1|root,COG0456@2|Bacteria,1VCET@1239|Firmicutes,4HDB3@91061|Bacilli,1ZFSH@1386|Bacillus	91061|Bacilli	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_242357_1	1191523.MROS_1368	1.21e-94	287.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	exuT	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
k59_532485_1	296591.Bpro_4149	3.9e-71	238.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,4AAXQ@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_572144_1	998088.B565_1433	1.89e-49	166.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,1S40A@1236|Gammaproteobacteria,1Y5Z6@135624|Aeromonadales	135624|Aeromonadales	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
k59_572144_2	153948.NAL212_1480	8.16e-53	169.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,2VSZE@28216|Betaproteobacteria,373EC@32003|Nitrosomonadales	28216|Betaproteobacteria	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_186972_2	47716.JOFH01000054_gene5456	1.09e-08	57.8	COG0640@1|root,COG0640@2|Bacteria,2GKFK@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_841351_1	292415.Tbd_0963	6.39e-92	278.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,1KRKH@119069|Hydrogenophilales	119069|Hydrogenophilales	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
k59_248841_1	436308.Nmar_0569	5.09e-60	189.0	arCOG10529@1|root,arCOG10529@2157|Archaea,41T4K@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1023829_1	748280.NH8B_2732	1.55e-07	51.6	COG0625@1|root,COG0625@2|Bacteria,1RK1K@1224|Proteobacteria,2WEV9@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N_3
k59_1023829_2	472759.Nhal_0303	4e-87	259.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,1S1HV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_56313_1	768066.HELO_4435	1.12e-82	265.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1XHD3@135619|Oceanospirillales	135619|Oceanospirillales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_350468_1	667014.Thein_2196	2.79e-64	210.0	COG0174@1|root,COG0174@2|Bacteria,2GH5N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_154967_2	596153.Alide_3614	9.44e-08	53.9	COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2VKFW@28216|Betaproteobacteria,4AH9U@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
k59_187927_1	1121428.DESHY_60297___1	2.72e-47	168.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,26187@186807|Peptococcaceae	186801|Clostridia	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_316921_1	1120977.JHUX01000003_gene2051	1.16e-77	243.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,3NIR4@468|Moraxellaceae	1236|Gammaproteobacteria	I	Fatty acid desaturase	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_91160_2	1192868.CAIU01000012_gene1470	4.75e-25	94.7	COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,43M7Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_91160_3	648757.Rvan_2997	1.15e-56	180.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2TSRI@28211|Alphaproteobacteria,3N6DJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_842403_1	935840.JAEQ01000008_gene790	2.93e-35	129.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,43IQF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_187932_1	396588.Tgr7_0340	4.21e-96	306.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1WWPF@135613|Chromatiales	135613|Chromatiales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1003705_2	1121403.AUCV01000044_gene25	1.32e-34	132.0	COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,42PB6@68525|delta/epsilon subdivisions,2WJJ9@28221|Deltaproteobacteria,2MHWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF3369)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,HD,HD_5,Response_reg
k59_91162_1	1122963.AUHB01000006_gene2434	3.46e-09	58.5	COG4977@1|root,COG4977@2|Bacteria,1MXSX@1224|Proteobacteria,2TZN5@28211|Alphaproteobacteria,371K9@31993|Methylocystaceae	28211|Alphaproteobacteria	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
k59_91162_2	595460.RRSWK_01652	1.18e-18	85.1	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K03444	-	-	-	-	ko00000,ko02000	2.A.1.1	-	-	Sugar_tr
k59_1024314_1	204773.HEAR0225	4.21e-92	277.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VHFS@28216|Betaproteobacteria,4737I@75682|Oxalobacteraceae	28216|Betaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	gltI	-	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_91171_2	497321.C664_00925	6.54e-48	164.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VK57@28216|Betaproteobacteria,2KV84@206389|Rhodocyclales	206389|Rhodocyclales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroA	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_316943_1	566466.NOR53_723	2.9e-93	283.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RMBJ@1236|Gammaproteobacteria,1J9SX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
k59_123206_1	555778.Hneap_1402	1.22e-27	112.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_645150_1	797114.C475_13437	5.23e-08	56.6	COG0596@1|root,arCOG01648@2157|Archaea,2XUNG@28890|Euryarchaeota,23SVU@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	catD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_842424_1	1565314.OA34_00835	3.4e-07	57.4	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,42M50@68525|delta/epsilon subdivisions,2YMT2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748,OmpA
k59_972688_1	265072.Mfla_1678	1.05e-24	107.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,2KKF7@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_972688_2	1157708.KB907450_gene5196	3.45e-47	155.0	COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,2VRD4@28216|Betaproteobacteria,4AEJW@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	gloA3	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_972688_3	375286.mma_0185	1.86e-72	230.0	2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2VKQ6@28216|Betaproteobacteria,476M3@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_25590_1	1247649.D560_2345	5.43e-48	166.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2VKNE@28216|Betaproteobacteria,3T1NT@506|Alcaligenaceae	28216|Betaproteobacteria	S	Permeases of the major facilitator superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_972690_1	1232437.KL661953_gene2319	6.8e-55	186.0	COG1042@1|root,COG1042@2|Bacteria,1R8Q6@1224|Proteobacteria,42NR2@68525|delta/epsilon subdivisions,2WM2A@28221|Deltaproteobacteria,2MN2C@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
k59_187958_1	1410616.JHXE01000013_gene205	1.79e-12	64.7	COG2172@1|root,COG2172@2|Bacteria,1VAPM@1239|Firmicutes,24J9J@186801|Clostridia,3NHAJ@46205|Pseudobutyrivibrio	186801|Clostridia	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
k59_187958_2	439235.Dalk_1049	1.75e-35	124.0	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,42V1I@68525|delta/epsilon subdivisions,2WRH0@28221|Deltaproteobacteria,2MKP1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
k59_25592_1	257310.BB1573	1.11e-51	179.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,3T1XI@506|Alcaligenaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_536600_1	525368.HMPREF0591_2430	1.25e-23	102.0	2DBBP@1|root,2Z88Z@2|Bacteria,2I46S@201174|Actinobacteria,2329E@1762|Mycobacteriaceae	201174|Actinobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_744241_1	95619.PM1_0217225	2.58e-66	225.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Pfam Glycosyl transferase family 2	bcsA	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,PilZ
k59_123225_1	439235.Dalk_1289	1.77e-39	145.0	arCOG12798@1|root,2Z9Z0@2|Bacteria,1R8E8@1224|Proteobacteria,42VRJ@68525|delta/epsilon subdivisions,2WS8M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_679046_1	452637.Oter_4432	3.06e-103	328.0	COG3696@1|root,COG3696@2|Bacteria,46SJ1@74201|Verrucomicrobia,3K7EV@414999|Opitutae	414999|Opitutae	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_220507_1	1163617.SCD_n02789	5.27e-134	405.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria	28216|Betaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_2,Thioredoxin_7
k59_940027_1	1229909.NSED_07395	1.51e-58	197.0	COG0405@1|root,arCOG04053@2157|Archaea	2157|Archaea	E	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_972708_1	768066.HELO_3976	6.3e-56	196.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XHKJ@135619|Oceanospirillales	135619|Oceanospirillales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_940035_1	985867.AEWF01000002_gene1598	4.24e-66	204.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,47FAT@766|Rickettsiales	766|Rickettsiales	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k59_940035_2	431943.CKL_0220	7.65e-26	100.0	COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,36DC5@31979|Clostridiaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_413073_2	330214.NIDE0952	1.03e-43	150.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	3.6.1.11,3.6.1.40	ko:K01524,ko:K07012	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000,ko02048	-	-	-	HD
k59_744260_1	1532558.JL39_24415	9.61e-36	133.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,4B73C@82115|Rhizobiaceae	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_842470_1	457570.Nther_0099	8.71e-10	61.2	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_842470_2	1123075.AUDP01000011_gene1909	8.06e-24	101.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,3WGZ1@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB
k59_478049_1	196367.JNFG01000209_gene256	2.91e-279	775.0	COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4277
k59_515538_1	228410.NE2327	9.72e-130	385.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,372EW@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_842473_1	926692.AZYG01000085_gene808	2.58e-06	48.5	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WAA8@53433|Halanaerobiales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_842473_2	945713.IALB_1989	6.7e-41	135.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_536616_1	358220.C380_05795	4.42e-105	331.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_220529_1	240016.ABIZ01000001_gene2819	2.41e-86	272.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_57338_1	1280954.HPO_10602	3.98e-25	102.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,43W5F@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_57338_2	742159.HMPREF0004_2769	8.52e-30	115.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,3T4KF@506|Alcaligenaceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase	-	-	4.2.1.18	ko:K13766,ko:K15312	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	ECH_1
k59_155998_1	944480.ATUV01000001_gene1627	3.61e-51	171.0	COG2191@1|root,COG2191@2|Bacteria,1RC3D@1224|Proteobacteria,42QXB@68525|delta/epsilon subdivisions,2WMUZ@28221|Deltaproteobacteria,2M6FC@213113|Desulfurellales	28221|Deltaproteobacteria	C	FmdE, Molybdenum formylmethanofuran dehydrogenase operon	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
k59_842477_1	1266925.JHVX01000002_gene1028	3.74e-36	137.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2VPE5@28216|Betaproteobacteria,372J2@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Saccharopine dehydrogenase C-terminal domain	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_351515_1	640081.Dsui_1270	2.15e-130	384.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,2KUHV@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_905070_1	1005048.CFU_4067	8.14e-42	145.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,472XC@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	ThiF family	thiF	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_905070_2	323848.Nmul_A1119	2.03e-47	167.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,372E5@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_91234_1	945713.IALB_2407	1.88e-37	130.0	COG0782@1|root,COG0782@2|Bacteria	2|Bacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_91234_2	945713.IALB_1293	2.04e-24	105.0	COG1523@1|root,COG4935@1|root,COG1523@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	PUD,Reprolysin_4
k59_792732_1	1123020.AUIE01000009_gene3862	5.95e-12	71.2	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1YFEW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	7TM diverse intracellular signalling	mmoS	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE5,HATPase_c,HisKA,Response_reg
k59_744282_1	1229909.NSED_07885	7.88e-17	73.6	arCOG10410@1|root,arCOG10410@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_744282_2	436308.Nmar_1446	1.39e-51	164.0	COG3432@1|root,arCOG01055@2157|Archaea,41SST@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
k59_57351_2	583355.Caka_2688	7.45e-07	52.0	COG3637@1|root,COG3637@2|Bacteria,46W5R@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_711863_1	207559.Dde_2300	1.74e-32	123.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,2MAXD@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM toluene tolerance family protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_612859_2	1242864.D187_006660	8.52e-92	280.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales	28221|Deltaproteobacteria	H	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_188027_1	338963.Pcar_3052	8.61e-77	246.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_156023_1	479434.Sthe_1855	2.08e-22	98.2	COG1030@1|root,COG1030@2|Bacteria,2G6E2@200795|Chloroflexi,27XU8@189775|Thermomicrobia	189775|Thermomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_542479_1	1415780.JPOG01000001_gene2508	9.27e-60	205.0	2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_781017_1	1229909.NSED_09365	9.61e-23	102.0	arCOG06854@1|root,arCOG06854@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_258284_1	502025.Hoch_5989	1.21e-58	199.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4M@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	sasR	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_486294_1	330214.NIDE0795	1.8e-161	459.0	COG0332@1|root,COG0332@2|Bacteria,3J0FW@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_796431_1	640081.Dsui_0389	2.33e-109	327.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,2KVNS@206389|Rhodocyclales	206389|Rhodocyclales	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_258304_1	697282.Mettu_3259	1.94e-79	250.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XEUM@135618|Methylococcales	135618|Methylococcales	P	PFAM Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_421760_1	395492.Rleg2_5468	3.45e-12	72.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2U05K@28211|Alphaproteobacteria,4B7G2@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,TAT_signal
k59_796438_1	861299.J421_0453	1.19e-24	107.0	COG1538@1|root,COG1538@2|Bacteria,1ZUXT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_486330_1	104355.XP_007867625.1	3.07e-10	65.1	COG2041@1|root,KOG0535@2759|Eukaryota,39MGM@33154|Opisthokonta,3NZ8X@4751|Fungi,3V42G@5204|Basidiomycota,225SM@155619|Agaricomycetes,3H246@355688|Agaricomycetes incertae sedis	4751|Fungi	C	Molybdopterin binding oxidoreductase	-	-	1.8.3.1	ko:K00387	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_486335_1	323848.Nmul_A1971	2.21e-06	53.5	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VHQP@28216|Betaproteobacteria,371T7@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Biotin-lipoyl like	mdtA1	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_258329_1	671143.DAMO_2568	7.01e-77	237.0	COG1432@1|root,COG1432@2|Bacteria,2NQWI@2323|unclassified Bacteria	2|Bacteria	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_258333_1	1384484.AEQU_1480	5.38e-101	300.0	COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4CUAA@84998|Coriobacteriia	84998|Coriobacteriia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_486345_1	1266925.JHVX01000008_gene239	1.24e-155	450.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,371M5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.2.4,1.1.3.15,1.1.5.12	ko:K00102,ko:K00104,ko:K03777	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475,R00704,R11591	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_486345_2	760117.JN27_10815	9.39e-05	44.3	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,4725H@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD_binding_4
k59_796445_1	1298867.AUES01000085_gene3659	8.09e-12	64.7	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_796445_2	1298867.AUES01000085_gene3659	2.17e-15	78.6	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_542594_1	1005048.CFU_3298	1.53e-49	162.0	COG5580@1|root,COG5580@2|Bacteria,1NMBI@1224|Proteobacteria,2W5GZ@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_1029448_1	497321.C664_06953	7.9e-83	256.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,2KUKH@206389|Rhodocyclales	206389|Rhodocyclales	T	Sigma E regulatory protein, MucB RseB	rseB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_486355_1	1408164.MOLA814_01644	2.96e-20	86.7	COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,2VSDZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_486355_2	1150626.PHAMO_180154	1.54e-05	47.4	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,2JP9M@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_421813_1	1131553.JIBI01000018_gene521	1.54e-25	104.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2VH1E@28216|Betaproteobacteria,371RK@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Dihydroorotase, multifunctional complex type	pyrX	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_421813_2	1288494.EBAPG3_28030	4.17e-75	244.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,371SQ@32003|Nitrosomonadales	28216|Betaproteobacteria	E	M3B, thimet oligopeptidase F	prlC	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_542598_1	228405.HNE_1437	1.33e-70	224.0	COG0625@1|root,COG0625@2|Bacteria,1R3VG@1224|Proteobacteria,2U50H@28211|Alphaproteobacteria,43XSS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	COG0625 Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
k59_542598_2	400668.Mmwyl1_0216	3.2e-11	63.2	COG0754@1|root,COG3942@1|root,COG0754@2|Bacteria,COG3942@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria,1XHKB@135619|Oceanospirillales	135619|Oceanospirillales	E	Glutathionylspermidine synthase	-	-	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CHAP,GSP_synth
k59_781127_2	945713.IALB_2366	1.33e-76	231.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_486420_1	933262.AXAM01000019_gene1124	3.94e-105	318.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,42MR9@68525|delta/epsilon subdivisions,2WIP3@28221|Deltaproteobacteria,2MIXN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Aminotransferase class-V	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
k59_486435_1	580332.Slit_2854	1.11e-26	100.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,44VSU@713636|Nitrosomonadales	28216|Betaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_781234_1	330214.NIDE0789	3.55e-47	154.0	COG0360@1|root,COG0360@2|Bacteria,3J0VS@40117|Nitrospirae	40117|Nitrospirae	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
k59_781234_2	330214.NIDE0790	1.92e-19	81.3	COG0629@1|root,COG0629@2|Bacteria,3J0NB@40117|Nitrospirae	40117|Nitrospirae	L	Single-strand binding protein family	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_258495_1	261292.Nit79A3_3014	4.7e-84	271.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,372UR@32003|Nitrosomonadales	28216|Betaproteobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1029521_1	1122164.JHWF01000034_gene2198	1.14e-24	105.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1JFDJ@118969|Legionellales	118969|Legionellales	E	GMC oxidoreductase	neoG	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_258504_1	582744.Msip34_2309	6.79e-73	228.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KKH8@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_258504_2	1031711.RSPO_c03065	6.15e-45	152.0	29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,2VT0U@28216|Betaproteobacteria,1K734@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
k59_284452_1	1454004.AW11_02064	2.39e-79	246.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,1KQJ0@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_258522_1	1242864.D187_000074	8.47e-70	222.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2WIYC@28221|Deltaproteobacteria,2YTSX@29|Myxococcales	28221|Deltaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_258522_2	1267535.KB906767_gene5292	0.000145	43.1	COG0013@1|root,COG0013@2|Bacteria,3Y359@57723|Acidobacteria,2JIIR@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_422017_1	247634.GPB2148_2989	4.79e-84	257.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,1S08S@1236|Gammaproteobacteria,1J842@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_781278_1	1005048.CFU_4120	2.52e-51	171.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,4728D@75682|Oxalobacteraceae	28216|Betaproteobacteria	D	Actin	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_781278_2	266264.Rmet_0052	1.23e-73	236.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,1K372@119060|Burkholderiaceae	28216|Betaproteobacteria	M	shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_1029540_1	713586.KB900536_gene40	3.7e-72	239.0	COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,1RPN6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	hydrolase family 65, central catalytic	ycjT	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016787,GO:0030312,GO:0044464,GO:0071944	2.4.1.64,3.2.1.28,5.4.2.6	ko:K01194,ko:K01838,ko:K04844,ko:K05342	ko00500,ko01100,map00500,map01100	-	R00010,R02727,R02728,R11310	RC00049,RC00408	ko00000,ko00001,ko00537,ko01000	-	GH37,GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
k59_258534_1	404380.Gbem_1224	3.43e-72	232.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions,2WJ6Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_422038_1	1163617.SCD_n02102	1.31e-23	99.8	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,2WH69@28216|Betaproteobacteria	28216|Betaproteobacteria	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	pilS	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA
k59_422038_2	640081.Dsui_0135	2.97e-41	148.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KUM4@206389|Rhodocyclales	206389|Rhodocyclales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_486543_1	671143.DAMO_1149	1.39e-41	139.0	COG1278@1|root,COG1278@2|Bacteria,2NPTN@2323|unclassified Bacteria	2|Bacteria	K	Probable zinc-ribbon domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD,Ribosomal_S30AE,zf-trcl
k59_258567_1	713586.KB900536_gene425	4.53e-68	216.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1WWQ8@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_258567_2	1121937.AUHJ01000002_gene3378	2.18e-11	63.5	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,464VM@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_486564_1	314285.KT71_04955	5.79e-56	186.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1J7FX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_542877_1	266265.Bxe_A4423	1.56e-17	81.6	COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2VHIZ@28216|Betaproteobacteria,1K2W9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_542877_2	1532557.JL37_19035	2.44e-42	154.0	COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_486601_1	330214.NIDE3714	3.41e-55	182.0	COG0739@1|root,COG0739@2|Bacteria,3J0N3@40117|Nitrospirae	40117|Nitrospirae	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_486601_2	1463879.JOHP01000102_gene2545	7.75e-07	48.9	COG1324@1|root,COG1324@2|Bacteria,2IQF1@201174|Actinobacteria	201174|Actinobacteria	P	Divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
k59_284514_1	398578.Daci_5041	3.95e-76	242.0	COG0330@1|root,COG0330@2|Bacteria,1MXFX@1224|Proteobacteria,2VP3U@28216|Betaproteobacteria,4AH52@80864|Comamonadaceae	28216|Betaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_284520_1	945713.IALB_2396	7.78e-34	134.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Sortilin-Vps10
k59_542934_1	1249627.D779_3949	5.98e-39	134.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria,1WXZR@135613|Chromatiales	135613|Chromatiales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_542934_2	1123368.AUIS01000005_gene381	5.72e-26	103.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,2NCK6@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Belongs to the TtcA family	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_258684_1	62928.azo1014	6.43e-111	330.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,2KV65@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_422207_2	288000.BBta_6382	2.09e-34	130.0	COG3772@1|root,COG5526@1|root,COG3772@2|Bacteria,COG5526@2|Bacteria,1RA0A@1224|Proteobacteria,2U252@28211|Alphaproteobacteria,3JSJ5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
k59_258700_1	266265.Bxe_B2862	5.61e-47	168.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,1K17G@119060|Burkholderiaceae	28216|Betaproteobacteria	G	SMART alpha amylase, catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_258700_2	479434.Sthe_1093	5.02e-63	212.0	COG0366@1|root,COG0366@2|Bacteria,2G89J@200795|Chloroflexi,27XYW@189775|Thermomicrobia	189775|Thermomicrobia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_781470_1	1121035.AUCH01000017_gene2236	2.51e-127	390.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
k59_258705_1	1449353.JQMQ01000005_gene4509	1.3e-25	109.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,2NF37@228398|Streptacidiphilus	201174|Actinobacteria	Q	Cytochrome P450	cyp125	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0036199,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044238,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0046164,GO:0046906,GO:0048037,GO:0051704,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652	1.14.13.141	ko:K15981	ko00984,ko01120,map00984,map01120	-	R09859,R11357	RC01216,RC03368	ko00000,ko00001,ko00199,ko01000	-	-	-	p450
k59_258707_1	357808.RoseRS_3759	1.76e-13	75.9	COG1287@1|root,COG1287@2|Bacteria,2G8T3@200795|Chloroflexi,376JU@32061|Chloroflexia	32061|Chloroflexia	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_258710_1	330214.NIDE0602	1.05e-51	177.0	COG1007@1|root,COG1007@2|Bacteria,3J0FN@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_258710_2	330214.NIDE0601	1.31e-22	95.1	COG1295@1|root,COG1295@2|Bacteria,3J17V@40117|Nitrospirae	40117|Nitrospirae	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_284567_1	1437448.AZRT01000005_gene4411	6.74e-86	271.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,2TRPY@28211|Alphaproteobacteria,1J1FM@118882|Brucellaceae	28211|Alphaproteobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_796617_1	443144.GM21_0014	2.36e-114	337.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,43TYP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_1029655_1	398767.Glov_3474	4.89e-23	95.5	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,42QTI@68525|delta/epsilon subdivisions,2WMRH@28221|Deltaproteobacteria,43SYN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_284583_1	1394178.AWOO02000025_gene4984	8.97e-70	226.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4EMIP@85012|Streptosporangiales	201174|Actinobacteria	Q	Cytochrome P450	cyp51	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0008398,GO:0016125,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0032451,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0055114,GO:0070988,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901615	1.14.13.70	ko:K05917	ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130	M00101	R05640,R05731	RC01442	ko00000,ko00001,ko00002,ko00199,ko01000	-	-	-	p450
k59_258784_1	436308.Nmar_0424	5.15e-62	196.0	COG1208@1|root,arCOG00663@2157|Archaea	2157|Archaea	M	PFAM Nucleotidyl transferase	-	-	2.6.1.37,2.7.7.13	ko:K00966,ko:K03430	ko00051,ko00440,ko00520,ko01100,ko01110,ko01120,map00051,map00440,map00520,map01100,map01110,map01120	M00114,M00361,M00362	R00885,R04152	RC00002,RC00008,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	NTP_transferase
k59_422328_1	32057.KB217478_gene5774	1.77e-43	157.0	COG3385@1|root,COG3385@2|Bacteria,1G3T3@1117|Cyanobacteria,1HNHF@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_796647_1	1038922.PflQ2_2441	1.29e-15	83.2	COG3503@1|root,COG3503@2|Bacteria,1QQ9D@1224|Proteobacteria,1RMPY@1236|Gammaproteobacteria,1YSJ7@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
k59_290481_1	1123322.KB904673_gene2936	5.09e-39	147.0	COG3540@1|root,COG3540@2|Bacteria,2GJCI@201174|Actinobacteria	201174|Actinobacteria	P	alkaline phosphatase	phoD	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
k59_549827_1	1068978.AMETH_0443	3.28e-05	51.2	COG3170@1|root,COG3170@2|Bacteria,2GJWK@201174|Actinobacteria,4E2YJ@85010|Pseudonocardiales	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_290486_1	1144319.PMI16_01534	2.11e-66	207.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2VQDH@28216|Betaproteobacteria,4736X@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Redoxin	ahp1	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
k59_1034611_1	338969.Rfer_3775	1.17e-91	285.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_290527_1	1000565.METUNv1_01937	3.77e-53	187.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,2KU7U@206389|Rhodocyclales	206389|Rhodocyclales	M	penicillin-binding protein 1A	mcrA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_264261_1	379066.GAU_0378	3.35e-23	101.0	COG0842@1|root,COG0842@2|Bacteria,1ZTNY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_394439_1	404589.Anae109_1931	4.98e-82	257.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2YU46@29|Myxococcales	28221|Deltaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_427283_1	439235.Dalk_3782	1.44e-104	321.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,43BUE@68525|delta/epsilon subdivisions,2X75I@28221|Deltaproteobacteria,2MPKE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Conserved carboxylase domain	oadA	-	2.1.3.1,4.1.1.3,6.4.1.1	ko:K01571,ko:K01960,ko:K03416	ko00020,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00640,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344,R00353,R00930	RC00040,RC00097,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_558176_1	1269813.ATUL01000012_gene382	7.4e-27	115.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXCR@135613|Chromatiales	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CZB,EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9,Protoglobin
k59_688800_1	666681.M301_1538	2.05e-31	123.0	COG0845@1|root,COG0845@2|Bacteria,1R6JG@1224|Proteobacteria,2VUA5@28216|Betaproteobacteria,2KKVF@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_688800_2	1165096.ARWF01000001_gene165	2.8e-41	153.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KKBT@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_68464_1	1000565.METUNv1_02260	7.24e-105	323.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,2KUP0@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_721317_1	365528.KB891267_gene5932	5.96e-33	126.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_721317_2	1144307.PMI04_03355	4.4e-14	72.4	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria,2K2ZU@204457|Sphingomonadales	28211|Alphaproteobacteria	EH	PFAM Thiamine pyrophosphate enzyme, central domain, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_133678_1	1121405.dsmv_0617	6.79e-91	278.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,42NHH@68525|delta/epsilon subdivisions,2WJ6M@28221|Deltaproteobacteria,2MIS1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	qmoA	-	-	ko:K16885	-	-	-	-	ko00000	-	-	-	FAD_oxidored,NAD_binding_8,Pyr_redox_2
k59_917358_1	555778.Hneap_0865	5.94e-73	233.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,1WW9I@135613|Chromatiales	135613|Chromatiales	E	PFAM aminotransferase class V	-	-	2.6.1.112,2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830,ko:K00839	ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588,R10908	RC00006,RC00008,RC00018,RC03305	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_296689_1	247634.GPB2148_96	3.44e-57	199.0	2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_656141_1	247490.KSU1_C0449	2.42e-10	66.6	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,DUF4347,Peptidase_S8
k59_232201_2	402626.Rpic_3512	1.39e-45	159.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1K2Y1@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_820609_1	469616.FMAG_00698	6.56e-19	94.7	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,37AID@32066|Fusobacteria	32066|Fusobacteria	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
k59_852814_1	713586.KB900536_gene2508	8.18e-53	177.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales	135613|Chromatiales	GM	NAD-dependent epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_885268_1	203119.Cthe_0408	1.31e-44	165.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3WGTE@541000|Ruminococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	EAL,GGDEF,HisKA_7TM,PAS_3,PAS_9,SBP_bac_3
k59_950962_1	999425.HMPREF9186_01660	8.34e-19	85.9	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
k59_983328_1	1035197.HMPREF9999_00085	5.22e-88	267.0	COG4152@1|root,COG4152@2|Bacteria,4NEJE@976|Bacteroidetes,2FMK3@200643|Bacteroidia,1WCXA@1283313|Alloprevotella	976|Bacteroidetes	S	Domain of unknown function (DUF4162)	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_885276_1	62928.azo1049	3.62e-137	393.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria,2KUCF@206389|Rhodocyclales	206389|Rhodocyclales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_36933_1	1254432.SCE1572_47635	9.01e-39	148.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
k59_494215_1	1454004.AW11_03329	2.01e-154	450.0	COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,2VJXX@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_200087_1	109760.SPPG_05489T0	2.75e-35	137.0	2CMGD@1|root,2QQ9V@2759|Eukaryota,39B3J@33154|Opisthokonta	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2,Rho_N
k59_983330_1	1229909.NSED_09680	1.37e-120	348.0	arCOG01806@1|root,arCOG01806@2157|Archaea,41T2B@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_591917_1	1079460.ATTQ01000053_gene6343	2.75e-220	609.0	COG2801@1|root,COG2801@2|Bacteria,1MVQ9@1224|Proteobacteria,2TTHG@28211|Alphaproteobacteria,4BEYU@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve,rve_3
k59_820638_2	57918.XP_004294107.1	7.38e-07	58.5	COG0604@1|root,KOG1198@2759|Eukaryota,37QSV@33090|Viridiplantae,3GDXJ@35493|Streptophyta,4JFUJ@91835|fabids	35493|Streptophyta	C	Reticulon-4-interacting protein 1	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0007275,GO:0007399,GO:0008150,GO:0009987,GO:0010975,GO:0016020,GO:0019867,GO:0022008,GO:0030154,GO:0031090,GO:0031344,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045664,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050773,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051239,GO:0051960,GO:0060284,GO:0065007,GO:0098588,GO:0098805,GO:0120035,GO:2000026	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_232230_1	483219.LILAB_13990	1.8e-24	105.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,42Q8I@68525|delta/epsilon subdivisions,2X5IX@28221|Deltaproteobacteria,2YYPK@29|Myxococcales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_363135_1	1120999.JONM01000009_gene326	4.97e-09	58.2	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2VH1G@28216|Betaproteobacteria,2KQSK@206351|Neisseriales	206351|Neisseriales	G	Starch synthase catalytic domain	glgA	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_5,Glycos_transf_1
k59_494230_1	1128398.Curi_c20740	1.45e-14	75.1	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,268B4@186813|unclassified Clostridiales	186801|Clostridia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_494230_2	1430440.MGMSRv2_4180	0.000887	42.0	COG3959@1|root,COG3959@2|Bacteria,1MWRX@1224|Proteobacteria,2TRA2@28211|Alphaproteobacteria,2JSGM@204441|Rhodospirillales	204441|Rhodospirillales	G	COG3959 Transketolase, N-terminal subunit	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_297788_1	864069.MicloDRAFT_00001810	7.36e-48	165.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_28,HTH_29,HTH_33
k59_950981_1	323848.Nmul_A2744	1.23e-28	112.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,3726R@32003|Nitrosomonadales	28216|Betaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	ybhF_1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_950981_2	292.DM42_1400	8.65e-78	240.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,1JZYY@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_36950_1	1267535.KB906767_gene1053	1.99e-61	212.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria,2JHRN@204432|Acidobacteriia	204432|Acidobacteriia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_36954_1	395494.Galf_0341	9.02e-101	300.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,44V9K@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_4252_2	323848.Nmul_A0733	6.72e-12	63.2	2ERQA@1|root,33J9N@2|Bacteria,1NI0Z@1224|Proteobacteria,2VYZY@28216|Betaproteobacteria,373P2@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_428455_1	1515746.HR45_10310	9.67e-128	381.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,2QAEP@267890|Shewanellaceae	1236|Gammaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_428455_2	292415.Tbd_0156	3.71e-22	90.5	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,2VN9B@28216|Betaproteobacteria	28216|Betaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_363156_1	6211.A0A068Y3R8	4.71e-22	94.0	2DZJG@1|root,2S72Z@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_265484_1	948071.S4S2D9_9CAUD	4.09e-55	191.0	4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses  no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae	10744|Podoviridae	S	ribonucleoside-triphosphate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_265484_4	268747.E2PU08_BPPRS	2.3e-08	54.7	4QAUK@10239|Viruses,4QWEQ@35237|dsDNA viruses  no RNA stage,4QQ1Z@28883|Caudovirales,4QIJA@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_428461_1	1144275.COCOR_01921	3.14e-71	226.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria,2YXV7@29|Myxococcales	28221|Deltaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k59_690068_1	1123504.JQKD01000013_gene1006	3.02e-131	400.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,4ABBZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_918614_1	1208321.D104_14515	9.28e-46	161.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria,1XJGZ@135619|Oceanospirillales	135619|Oceanospirillales	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_69734_1	1123371.ATXH01000008_gene275	1.23e-54	188.0	COG0621@1|root,COG0621@2|Bacteria,2GGUF@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_983378_1	1123279.ATUS01000001_gene736	1.05e-34	132.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1J57J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0071704,GO:0090407,GO:1901576	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iEcDH1_1363.EcDH1_2557,iSFxv_1172.SFxv_1246,iY75_1357.Y75_RS05695	FA_synthesis
k59_918622_1	977880.RALTA_A1763	2.47e-43	155.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VJ8W@28216|Betaproteobacteria,1K21Y@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	dmlR2	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_918623_1	1380394.JADL01000001_gene2042	7.89e-92	289.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales	204441|Rhodospirillales	P	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_852885_1	330214.NIDE0726	7.49e-96	307.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_232261_1	1296416.JACB01000006_gene547	7.8e-57	186.0	COG0384@1|root,COG0384@2|Bacteria,4PGX7@976|Bacteroidetes,1IM7Z@117743|Flavobacteriia,2YKHA@290174|Aquimarina	976|Bacteroidetes	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
k59_494269_1	1123501.KB902294_gene3522	1.68e-30	119.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_494269_2	1207063.P24_13673	7.23e-189	540.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2JQSB@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
k59_4282_1	35841.BT1A1_1168	4.75e-07	57.4	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
k59_4282_2	1231391.AMZF01000094_gene118	6.48e-65	215.0	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_330681_1	383372.Rcas_0545	2.89e-36	137.0	COG1022@1|root,COG1022@2|Bacteria,2G5S9@200795|Chloroflexi,37561@32061|Chloroflexia	32061|Chloroflexia	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_330681_2	706587.Desti_3692	1.09e-49	166.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NI5@68525|delta/epsilon subdivisions,2WIN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_363175_1	1163617.SCD_n02500	1.3e-31	124.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,2VSUT@28216|Betaproteobacteria	28216|Betaproteobacteria	M	LppC putative lipoprotein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_722614_1	1265503.KB905164_gene1983	2.52e-46	169.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q6IX@267889|Colwelliaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_624597_1	1123399.AQVE01000002_gene2297	2.19e-74	238.0	COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,1RQSS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_591970_1	62928.azo3443	2.8e-98	298.0	COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2VI33@28216|Betaproteobacteria,2KVMF@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_428488_1	666685.R2APBS1_0798	1.52e-91	284.0	COG1012@1|root,COG1012@2|Bacteria,1QWN5@1224|Proteobacteria,1T508@1236|Gammaproteobacteria,1X5AD@135614|Xanthomonadales	135614|Xanthomonadales	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_102293_1	906888.JCM19314_3706	9.41e-09	62.0	COG0457@1|root,COG0457@2|Bacteria,4PMN3@976|Bacteroidetes,1IJVP@117743|Flavobacteriia	976|Bacteroidetes	M	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_330696_1	83406.HDN1F_01840	4.15e-20	87.8	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1J596@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type Mn2 Zn2 transport systems, permease	znuB	GO:0000006,GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010043,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	iEC042_1314.EC042_2026,iECABU_c1320.ECABU_c21210,iECED1_1282.ECED1_2064,iECNA114_1301.ECNA114_1921,iECSF_1327.ECSF_1717,iECUMN_1333.ECUMN_2157,iEcSMS35_1347.EcSMS35_1327,iG2583_1286.G2583_2311,iSSON_1240.SSON_1282,iYL1228.KPN_02374,ic_1306.c2273	ABC-3
k59_330696_2	1056820.KB900700_gene1180	2.44e-39	139.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,2PNEQ@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	P	ABC transporter	znuC	GO:0000041,GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005385,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008144,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	iSFV_1184.SFV_1859,iSF_1195.SF1867,iSFxv_1172.SFxv_2092,iS_1188.S1934	ABC_tran
k59_297848_1	1121937.AUHJ01000050_gene1244	1.09e-132	387.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,464M3@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_167613_1	335543.Sfum_0451	6.78e-74	247.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MR8V@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_102302_2	305900.GV64_24105	3.73e-29	114.0	COG1904@1|root,COG1904@2|Bacteria,1MVRI@1224|Proteobacteria,1RMRR@1236|Gammaproteobacteria,1XN48@135619|Oceanospirillales	135619|Oceanospirillales	G	Glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
k59_559499_4	1033732.CAHI01000035_gene2740	2.5e-27	103.0	2ES5W@1|root,32I7M@2|Bacteria,4PE4Q@976|Bacteroidetes,2FVZ0@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_559499_5	1120966.AUBU01000006_gene3216	7.01e-33	126.0	28JJ1@1|root,2Z9C5@2|Bacteria,4NJEU@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_698979_1	1128421.JAGA01000002_gene165	2.72e-41	149.0	COG2896@1|root,COG2896@2|Bacteria,2NP5R@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0040007,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22,4.6.1.17	ko:K03639,ko:K20967	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394,R11372	RC03420,RC03425	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_992948_1	382464.ABSI01000005_gene1029	6.47e-93	280.0	COG0022@1|root,COG0022@2|Bacteria,46S75@74201|Verrucomicrobia,2ITIV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Transketolase, pyrimidine binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C
k59_667538_1	435908.IDSA_10435	1.49e-06	50.1	COG0679@1|root,COG0679@2|Bacteria,1PHSS@1224|Proteobacteria,1RRY0@1236|Gammaproteobacteria,2QFU8@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_601802_1	880072.Desac_0822	1.53e-69	236.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_340481_1	575540.Isop_3482	6.02e-33	129.0	COG2204@1|root,COG2204@2|Bacteria,2IWYY@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_340481_2	485918.Cpin_6300	2.38e-12	71.2	COG5000@1|root,COG5000@2|Bacteria,4NE49@976|Bacteroidetes,1INZH@117747|Sphingobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	zraS_1	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_79815_1	1288494.EBAPG3_21940	3.94e-23	102.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,372RU@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	-	1.8.1.2,1.8.7.1	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858,R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_79815_2	323848.Nmul_A1147	8.42e-70	218.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2VIR0@28216|Betaproteobacteria,371TD@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_667548_1	1229780.BN381_430010	1.84e-29	116.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_862442_1	748247.AZKH_4278	4.07e-84	269.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KVGM@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_468619_1	287.DR97_101	8.78e-29	109.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,1S3YY@1236|Gammaproteobacteria,1YE37@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	ANTAR	nasT	-	-	ko:K07183	-	-	-	-	ko00000,ko02022	-	-	-	ANTAR,Response_reg
k59_468619_2	1000565.METUNv1_02007	1.08e-26	108.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2WA5U@28216|Betaproteobacteria,2KXHH@206389|Rhodocyclales	206389|Rhodocyclales	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_209708_2	1125863.JAFN01000001_gene267	2.4e-37	136.0	COG0811@1|root,COG0811@2|Bacteria,1NBED@1224|Proteobacteria,42WAH@68525|delta/epsilon subdivisions,2X5KM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	MotA TolQ ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_46755_1	439235.Dalk_3300	3.22e-66	211.0	COG0784@1|root,COG0784@2|Bacteria,1RHWK@1224|Proteobacteria,42SCZ@68525|delta/epsilon subdivisions,2WPGH@28221|Deltaproteobacteria,2MK6H@213118|Desulfobacterales	28221|Deltaproteobacteria	T	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_4
k59_468625_1	1095769.CAHF01000013_gene3221	3.88e-45	166.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,473UA@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_531239_1	748247.AZKH_1887	8.73e-85	271.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria,2KXVQ@206389|Rhodocyclales	206389|Rhodocyclales	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	TPP_enzyme_C
k59_340507_1	658187.LDG_8357	6.46e-25	96.3	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1JESZ@118969|Legionellales	118969|Legionellales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_340507_2	314287.GB2207_06153	3.28e-35	127.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1J4FI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_634210_1	1304866.K413DRAFT_4671	5e-20	85.9	COG1479@1|root,COG1479@2|Bacteria,1UT92@1239|Firmicutes,251YK@186801|Clostridia	186801|Clostridia	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF262
k59_569495_1	335283.Neut_2009	1.79e-57	197.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,371PW@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Peptidase M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_209717_1	1266925.JHVX01000009_gene80	2.64e-63	206.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,37224@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase,HTH_6,SIS
k59_177432_1	1068980.ARVW01000001_gene5801	2.25e-72	231.0	COG0657@1|root,COG0657@2|Bacteria,2GTEV@201174|Actinobacteria,4DZK5@85010|Pseudonocardiales	201174|Actinobacteria	I	Alpha beta hydrolase	lipM	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_437912_1	373903.Hore_19440	3.74e-25	108.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_862455_2	713587.THITH_09475	3.38e-21	85.1	2DR87@1|root,33AMS@2|Bacteria,1NJ06@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_862455_4	159087.Daro_2873	2.58e-28	111.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria,2KVWV@206389|Rhodocyclales	206389|Rhodocyclales	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
k59_372686_1	323848.Nmul_A1143	1.25e-88	273.0	COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,2VH3D@28216|Betaproteobacteria,372A3@32003|Nitrosomonadales	28216|Betaproteobacteria	S	A domain family that is part of the cupin metalloenzyme superfamily.	ycfD	-	1.14.11.47	ko:K18850	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Cupin_4
k59_437922_1	1280390.CBQR020000063_gene1272	5.97e-20	94.4	COG0642@1|root,COG2205@2|Bacteria,1UEIC@1239|Firmicutes,4HDD8@91061|Bacilli,26RKT@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	4HB_MCP_1,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
k59_788264_1	477641.MODMU_4827	7.69e-71	223.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4ERQ0@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_14507_1	1041146.ATZB01000004_gene6514	2.11e-07	54.3	COG3485@1|root,COG3485@2|Bacteria,1MV6K@1224|Proteobacteria,2TUS4@28211|Alphaproteobacteria,4BEBI@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C
k59_14507_2	94624.Bpet1519	1.34e-17	79.3	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,3T38E@506|Alcaligenaceae	28216|Betaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_928709_1	1122139.KB907864_gene2077	1.41e-23	95.1	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1XQBW@135619|Oceanospirillales	135619|Oceanospirillales	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_928709_2	1266925.JHVX01000004_gene1247	3.25e-86	257.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2WBX2@28216|Betaproteobacteria,373YS@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_928709_3	1267600.JFGT01000002_gene260	6.16e-10	59.3	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,3VXW8@53335|Pantoea	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_504284_1	864051.BurJ1DRAFT_1156	2.43e-133	416.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1KISW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_403481_1	880072.Desac_0670	4.18e-63	212.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,42N40@68525|delta/epsilon subdivisions,2WKUV@28221|Deltaproteobacteria,2MRT9@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the alkaline phosphatase family	phoA	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
k59_961295_1	1499967.BAYZ01000097_gene4328	1.94e-19	87.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	ydeD	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_961295_2	1187848.AJYQ01000055_gene927	4.64e-24	100.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,1XSCB@135623|Vibrionales	135623|Vibrionales	E	COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_961297_1	1174528.JH992898_gene2276	6.67e-53	178.0	COG1409@1|root,COG1409@2|Bacteria,1G4KM@1117|Cyanobacteria	1117|Cyanobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_437946_1	323848.Nmul_A2758	1.06e-60	201.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2VKNE@28216|Betaproteobacteria,372VG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_307010_1	395495.Lcho_2922	1.61e-19	85.5	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2VIXW@28216|Betaproteobacteria,1KKC8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Hemerythrin,PNP_phzG_C,Putative_PNPOx
k59_307010_2	365046.Rta_27470	3.91e-12	64.7	COG2128@1|root,COG2128@2|Bacteria,1QKTS@1224|Proteobacteria,2VWVV@28216|Betaproteobacteria,4AIAM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_732797_1	1206731.BAGB01000013_gene2270	4.9e-09	57.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4FY7Y@85025|Nocardiaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	tcrA	-	-	ko:K02483,ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_961310_1	998088.B565_0410	9.89e-28	109.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1Y5YD@135624|Aeromonadales	135624|Aeromonadales	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_961310_2	1267534.KB906755_gene4312	6.2e-25	100.0	2E3RZ@1|root,32YPK@2|Bacteria,3Y86I@57723|Acidobacteria,2JN75@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_928733_2	1246995.AFR_06840	3.8e-79	242.0	COG3647@1|root,COG3647@2|Bacteria,2IATE@201174|Actinobacteria,4DE3X@85008|Micromonosporales	201174|Actinobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_273546_1	265072.Mfla_2135	5.83e-15	73.9	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,2KMNB@206350|Nitrosomonadales	206350|Nitrosomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_273546_2	323848.Nmul_A1045	1.6e-36	129.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2VJEI@28216|Betaproteobacteria,372H3@32003|Nitrosomonadales	28216|Betaproteobacteria	F	PFAM Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
k59_667627_1	266265.Bxe_B1230	1.31e-81	270.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_112254_1	383372.Rcas_2064	7.45e-93	282.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi,3766V@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_862509_1	1168067.JAGP01000001_gene322	4.27e-78	254.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,45ZVK@72273|Thiotrichales	72273|Thiotrichales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_928745_1	257313.BP0273	1.18e-26	101.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,3T40B@506|Alcaligenaceae	28216|Betaproteobacteria	S	Stringent starvation protein B	sspB	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
k59_928745_2	323848.Nmul_A1002	1.03e-120	347.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2VIAW@28216|Betaproteobacteria,372NI@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Glutathione S-transferase, N-terminal domain	sspA	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_862513_1	1046724.KB889875_gene1728	4.1e-05	43.1	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,467QW@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2001141	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_862513_2	1168065.DOK_03163	4.58e-25	105.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1J51F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113,GO:2000765,GO:2000766	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_569566_2	388739.RSK20926_13489	4.09e-40	142.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,2P43C@2433|Roseobacter	28211|Alphaproteobacteria	E	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component	MA20_19430	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,DLIC
k59_504341_1	292415.Tbd_2395	7.66e-54	170.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2VU9V@28216|Betaproteobacteria,1KT6W@119069|Hydrogenophilales	119069|Hydrogenophilales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_961337_2	929704.Myrod_2310	1.03e-05	48.9	COG2755@1|root,COG2755@2|Bacteria,4NGTK@976|Bacteroidetes,1HY1A@117743|Flavobacteriia,47HQU@76831|Myroides	976|Bacteroidetes	E	G-D-S-L family lipolytic protein	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL
k59_112271_1	56780.SYN_02226	2.15e-65	208.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42PP7@68525|delta/epsilon subdivisions,2WJ4T@28221|Deltaproteobacteria,2MR12@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_762504_1	441769.ABFU01000049_gene3710	9.59e-115	345.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,4HBVG@91061|Bacilli,1ZBRD@1386|Bacillus	91061|Bacilli	C	succinate dehydrogenase	sdhA	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS05640	FAD_binding_2,Succ_DH_flav_C
k59_46841_1	522306.CAP2UW1_2781	1.01e-41	156.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_340590_1	1437824.BN940_13966	7.99e-21	85.5	2E860@1|root,33BGB@2|Bacteria,1NGBB@1224|Proteobacteria,2VXKZ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_340590_2	1268622.AVS7_02946	1.01e-44	146.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,4AEXW@80864|Comamonadaceae	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_894701_1	754477.Q7C_987	2.64e-57	192.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,46007@72273|Thiotrichales	72273|Thiotrichales	S	DNA recombination protein RmuC	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_928779_1	926550.CLDAP_36610	2.2e-81	248.0	COG3293@1|root,COG3293@2|Bacteria,2G7YC@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_762506_1	93220.LV28_07755	1.64e-63	210.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,1K0EM@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_762506_3	671143.DAMO_1019	9.3e-70	224.0	COG1488@1|root,COG1488@2|Bacteria,2NNUE@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	iYO844.BSU31750	NAPRTase
k59_307053_1	945713.IALB_2960	1.11e-38	140.0	COG0810@1|root,COG2849@1|root,COG0810@2|Bacteria,COG2849@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarboxypepD_reg,MORN_2,TonB_C
k59_504361_1	1304877.KI519399_gene6079	1.36e-77	252.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2TQMP@28211|Alphaproteobacteria,3JWYH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glycosyltransferase family 20	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
k59_469437_1	582744.Msip34_1487	2.21e-77	256.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KKBT@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_373683_1	269799.Gmet_1268	3.64e-60	197.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,43SYE@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_54584_1	1313172.YM304_21410	5.24e-107	321.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CMW4@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S1-like RNA-binding domain	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_277576_1	90814.KL370891_gene1925	1.72e-12	72.4	COG0526@1|root,COG0526@2|Bacteria,1RB6H@1224|Proteobacteria,1S2QN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,LGT
k59_277576_2	177439.DP2952	3.37e-13	68.9	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,43DIW@68525|delta/epsilon subdivisions,2X8Q7@28221|Deltaproteobacteria,2MI8D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_577881_1	1411123.JQNH01000001_gene145	4.41e-109	322.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TUAN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport systems permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_870697_1	1265313.HRUBRA_00894	1.91e-29	117.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	yebA	-	-	-	-	-	-	-	-	-	-	-	OapA,OapA_N,Peptidase_M23
k59_870697_2	393595.ABO_0364	5.01e-09	58.2	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1XH7D@135619|Oceanospirillales	135619|Oceanospirillales	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
k59_277579_1	1459636.NTE_02261	5.22e-11	65.9	COG0457@1|root,arCOG03032@2157|Archaea,41SBD@651137|Thaumarchaeota	651137|Thaumarchaeota	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
k59_277579_2	977880.RALTA_A2563	2.47e-06	48.5	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,1K2CB@119060|Burkholderiaceae	28216|Betaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_610037_1	448385.sce5443	1.82e-25	110.0	COG0515@1|root,COG0642@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,43CV1@68525|delta/epsilon subdivisions,2X82T@28221|Deltaproteobacteria,2Z3JT@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_4,Pkinase
k59_642350_1	323848.Nmul_A2229	1.03e-156	467.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,3726S@32003|Nitrosomonadales	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_610041_1	706587.Desti_2230	5.5e-120	352.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,42NEN@68525|delta/epsilon subdivisions,2WKJP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_445923_1	756272.Plabr_1665	1.99e-91	282.0	COG3119@1|root,COG3119@2|Bacteria,2IXNZ@203682|Planctomycetes	203682|Planctomycetes	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_120500_1	264732.Moth_1909	5.71e-37	142.0	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,42FDP@68295|Thermoanaerobacterales	186801|Clostridia	C	Formate dehydrogenase alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_247230_1	1121403.AUCV01000001_gene690	1.25e-65	222.0	COG2204@1|root,COG4191@1|root,COG4564@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,COG4564@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria,2MIG9@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_380515_1	123899.JPQP01000023_gene3195	1.61e-11	67.4	COG1024@1|root,COG1024@2|Bacteria,1P3FI@1224|Proteobacteria,2VHYZ@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_153152_1	1458427.BAWN01000015_gene963	6.28e-33	119.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,4AEEQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM thioesterase superfamily protein	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_153152_2	420662.Mpe_A2952	2.68e-22	91.3	COG3063@1|root,COG3063@2|Bacteria,1PUFT@1224|Proteobacteria,2WATN@28216|Betaproteobacteria,1KP02@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_769632_1	1278073.MYSTI_04341	1.57e-38	147.0	COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,1MU6G@1224|Proteobacteria	1224|Proteobacteria	IQ	COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Bac_luciferase,Condensation,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
k59_937156_1	330214.NIDE1868	3.31e-84	276.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae	40117|Nitrospirae	H	Pterin binding enzyme	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
k59_902365_2	1459636.NTE_01815	2.28e-17	83.6	COG0183@1|root,arCOG01278@2157|Archaea,41SB7@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1001054_2	296591.Bpro_3938	1.24e-40	140.0	COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,2VRYZ@28216|Betaproteobacteria,4ADYE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_314454_1	1313172.YM304_41440	8.64e-42	150.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4CNYR@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_676142_1	667014.Thein_0805	7.2e-24	102.0	COG2048@1|root,COG2048@2|Bacteria,2GIEV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_676142_2	1265505.ATUG01000001_gene4650	7.7e-20	82.8	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
k59_870761_1	472759.Nhal_0560	2.35e-103	310.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1WVUQ@135613|Chromatiales	135613|Chromatiales	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_642397_1	522306.CAP2UW1_3983	1.15e-101	304.0	COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,2VMFB@28216|Betaproteobacteria	28216|Betaproteobacteria	M	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_937181_1	1232410.KI421415_gene2992	3.52e-27	108.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,43S70@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_937181_2	706191.PANA_2879	4.2e-50	162.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,3W0SR@53335|Pantoea	1236|Gammaproteobacteria	K	at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA)	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006808,GO:0008144,GO:0008150,GO:0009889,GO:0010565,GO:0017076,GO:0019216,GO:0019217,GO:0019222,GO:0030234,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042304,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046890,GO:0050789,GO:0050790,GO:0050794,GO:0062012,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_314465_1	1001240.GY21_21180	7.44e-15	79.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,4FM4P@85023|Microbacteriaceae	201174|Actinobacteria	L	Transposase	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_410555_1	384765.SIAM614_17234	4.3e-30	123.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2TV7R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mechanosensitive ion channel	-	-	-	ko:K16052,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3,1.A.23.4	-	-	MS_channel
k59_277614_1	1121405.dsmv_3754	1.66e-16	72.0	COG0291@1|root,COG0291@2|Bacteria,1QDQ4@1224|Proteobacteria,42VSG@68525|delta/epsilon subdivisions,2WREY@28221|Deltaproteobacteria,2MM1F@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_277614_2	1121405.dsmv_3755	2.37e-17	77.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,2MJW2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_610087_1	694427.Palpr_2581	3.82e-05	49.3	COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,2FREU@200643|Bacteroidia,22ZFA@171551|Porphyromonadaceae	976|Bacteroidetes	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1001073_1	314275.MADE_1006980	2.39e-27	115.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,4643D@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_348718_1	757424.Hsero_2803	2.32e-59	190.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2VHU1@28216|Betaproteobacteria,473UI@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	Short chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_512677_1	134676.ACPL_2726	3.16e-14	78.2	COG1352@1|root,COG1352@2|Bacteria,2HHZ1@201174|Actinobacteria	201174|Actinobacteria	NT	PFAM MCP methyltransferase, CheR-type	cheR	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheR,CheR_N,PAS,PAS_4,PAS_9
k59_969872_2	1121272.KB903259_gene6522	0.000239	44.3	COG0475@1|root,COG0475@2|Bacteria,2GIRC@201174|Actinobacteria	201174|Actinobacteria	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_380553_1	1454004.AW11_01056	7.68e-76	243.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_769670_1	1437824.BN940_17961	4.4e-80	255.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,3T1MB@506|Alcaligenaceae	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_348726_1	1131266.ARWQ01000002_gene468	2.82e-107	324.0	COG0129@1|root,arCOG04045@2157|Archaea,41SD0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_902410_1	1454004.AW11_03345	2.45e-72	237.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,1KQBW@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Bacterial type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_577972_1	891974.E05_42310	1.61e-07	58.5	COG0840@1|root,COG0840@2|Bacteria,1PGKC@1224|Proteobacteria,1RX0Y@1236|Gammaproteobacteria,283G9@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	NT	HAMP domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	-
k59_185325_1	1266925.JHVX01000003_gene405	4.81e-192	568.0	COG1330@1|root,COG2887@1|root,COG1330@2|Bacteria,COG2887@2|Bacteria,1QU90@1224|Proteobacteria,2VHNR@28216|Betaproteobacteria,37212@32003|Nitrosomonadales	28216|Betaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	3.1.11.5	ko:K01144	-	-	-	-	ko00000,ko01000	-	-	-	PDDEXK_1
k59_610103_1	436308.Nmar_0418	2.23e-46	153.0	arCOG04033@1|root,arCOG04033@2157|Archaea,41SM5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_610103_2	436308.Nmar_0419	4.24e-68	213.0	COG1478@1|root,arCOG02714@2157|Archaea,41SHA@651137|Thaumarchaeota	651137|Thaumarchaeota	H	F420-0:Gamma-glutamyl ligase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
k59_217843_1	742818.HMPREF9451_00832	2.04e-68	229.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4CU9B@84998|Coriobacteriia	84998|Coriobacteriia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_247275_1	395493.BegalDRAFT_0143	2.04e-11	63.2	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1S0BJ@1236|Gammaproteobacteria,460IC@72273|Thiotrichales	72273|Thiotrichales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_247275_2	497321.C664_00585	2.42e-114	337.0	COG5501@1|root,COG5501@2|Bacteria,1PB0I@1224|Proteobacteria,2VNJJ@28216|Betaproteobacteria,2KW2T@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulphur oxidation protein SoxZ	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ
k59_247275_3	1247726.MIM_c14480	5.81e-27	102.0	2C7YM@1|root,32RK3@2|Bacteria,1N2IQ@1224|Proteobacteria,2VX9I@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_512689_1	1056820.KB900696_gene3933	1.99e-56	187.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,2PNGA@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	MlaA lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_314490_1	1004149.AFOE01000031_gene478	0.000184	43.5	COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,1HXGJ@117743|Flavobacteriia	976|Bacteroidetes	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	3.4.13.19	ko:K01273,ko:K01274	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_C26,Peptidase_M19
k59_314490_2	1136163.M565_ctg5P1418	1.06e-33	130.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1XVZK@135623|Vibrionales	135623|Vibrionales	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_577975_1	1168034.FH5T_20565	1.83e-29	124.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_512692_2	568706.BN118_2439	2.91e-56	188.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,3T2KH@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_475596_1	340099.Teth39_2112	1.01e-48	161.0	COG1435@1|root,COG1435@2|Bacteria,1TRVM@1239|Firmicutes,24CVH@186801|Clostridia,42GF5@68295|Thermoanaerobacterales	186801|Clostridia	F	thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
k59_380565_1	706587.Desti_3164	5.58e-78	249.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_88383_1	977880.RALTA_A1960	4.51e-25	107.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VJI5@28216|Betaproteobacteria,1K2DS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_88383_2	1123072.AUDH01000009_gene458	3.17e-11	64.3	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17
k59_446003_1	765914.ThisiDRAFT_2777	1.51e-06	49.3	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales	135613|Chromatiales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1002155_1	95619.PM1_0201360	5.57e-79	246.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	O-acetylhomoserine	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	iJN746.PP_2528	Cys_Met_Meta_PP
k59_315496_1	436308.Nmar_0062	1.71e-102	307.0	COG0463@1|root,arCOG00894@2157|Archaea,41SAS@651137|Thaumarchaeota	651137|Thaumarchaeota	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
k59_971074_2	13249.RPRC013675-PA	0.000398	48.1	2CMRF@1|root,2QRK8@2759|Eukaryota,38BZ6@33154|Opisthokonta,3BC6D@33208|Metazoa,3CRA6@33213|Bilateria,41W09@6656|Arthropoda,3SING@50557|Insecta,3E8KI@33342|Paraneoptera	33208|Metazoa	O	Cartilage oligomeric matrix protein	COMP	GO:0000902,GO:0001501,GO:0001503,GO:0001932,GO:0001934,GO:0001936,GO:0001938,GO:0001968,GO:0002020,GO:0002682,GO:0002684,GO:0002685,GO:0002687,GO:0002688,GO:0002690,GO:0003416,GO:0003417,GO:0003674,GO:0005102,GO:0005178,GO:0005198,GO:0005201,GO:0005488,GO:0005496,GO:0005499,GO:0005509,GO:0005515,GO:0005518,GO:0005539,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005912,GO:0005924,GO:0005927,GO:0006928,GO:0006950,GO:0007155,GO:0007160,GO:0007275,GO:0007399,GO:0007517,GO:0007610,GO:0008150,GO:0008201,GO:0008284,GO:0008289,GO:0009653,GO:0009790,GO:0009887,GO:0009888,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010941,GO:0012505,GO:0014812,GO:0016043,GO:0016203,GO:0016477,GO:0016525,GO:0016528,GO:0016529,GO:0019220,GO:0019222,GO:0019842,GO:0019899,GO:0021700,GO:0022008,GO:0022603,GO:0022607,GO:0022610,GO:0030030,GO:0030054,GO:0030055,GO:0030154,GO:0030182,GO:0030198,GO:0030334,GO:0030335,GO:0030855,GO:0031012,GO:0031175,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031589,GO:0031594,GO:0032101,GO:0032103,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032879,GO:0032989,GO:0032990,GO:0032991,GO:0033554,GO:0033555,GO:0033627,GO:0034103,GO:0034976,GO:0035265,GO:0035989,GO:0036094,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0042127,GO:0042325,GO:0042327,GO:0042981,GO:0043062,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0043237,GO:0043394,GO:0043395,GO:0043931,GO:0043933,GO:0044085,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045202,GO:0045765,GO:0045937,GO:0046872,GO:0048265,GO:0048266,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048589,GO:0048646,GO:0048666,GO:0048699,GO:0048705,GO:0048731,GO:0048736,GO:0048799,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050678,GO:0050679,GO:0050730,GO:0050731,GO:0050789,GO:0050793,GO:0050794,GO:0050839,GO:0050840,GO:0050896,GO:0050920,GO:0050921,GO:0051093,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051216,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051270,GO:0051272,GO:0051451,GO:0051674,GO:0051716,GO:0060173,GO:0060231,GO:0060255,GO:0060343,GO:0060346,GO:0060348,GO:0060349,GO:0060350,GO:0060351,GO:0060429,GO:0060538,GO:0060548,GO:0061053,GO:0061061,GO:0061383,GO:0061430,GO:0061448,GO:0062023,GO:0065003,GO:0065007,GO:0070161,GO:0070977,GO:0071603,GO:0071622,GO:0071624,GO:0071695,GO:0071840,GO:0080090,GO:0090022,GO:0090023,GO:0090136,GO:0097159,GO:0097367,GO:0098609,GO:0098868,GO:0120036,GO:0120039,GO:1901342,GO:1901343,GO:1901681,GO:1902622,GO:1902624,GO:2000026,GO:2000145,GO:2000147,GO:2000181	-	ko:K04659	ko04145,ko04151,ko04510,ko04512,ko05144,ko05165,map04145,map04151,map04510,map04512,map05144,map05165	-	-	-	ko00000,ko00001,ko00536,ko04131,ko04147,ko04516	-	-	-	COMP,EGF,EGF_CA,TSP_3,TSP_C
k59_154369_1	313628.LNTAR_04741	1.15e-33	127.0	COG0603@1|root,COG0603@2|Bacteria	2|Bacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_154369_3	59919.PMM0536	7.03e-77	238.0	COG0302@1|root,COG0302@2|Bacteria,1G1K8@1117|Cyanobacteria,1MKP6@1212|Prochloraceae	1117|Cyanobacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.folE,iJN678.folE	GTP_cyclohydroI
k59_685356_2	1307437.J139_13095	3.02e-36	139.0	COG0308@1|root,COG0308@2|Bacteria,1MUV3@1224|Proteobacteria,1RS0E@1236|Gammaproteobacteria,2Q01Z@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_1009537_1	1163617.SCD_n00212	1.9e-20	85.9	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	algH	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1009537_2	1000565.METUNv1_03482	1.56e-42	153.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,2KUF7@206389|Rhodocyclales	206389|Rhodocyclales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_910854_1	45157.CMN051CT	2.55e-19	85.1	COG0720@1|root,KOG4105@2759|Eukaryota	2759|Eukaryota	H	6-pyruvoyltetrahydropterin synthase activity	-	GO:0003674,GO:0003824,GO:0003874,GO:0005488,GO:0005515,GO:0006066,GO:0006082,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0019752,GO:0034311,GO:0034312,GO:0034641,GO:0042364,GO:0042398,GO:0042558,GO:0042559,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046394,GO:0046483,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_910854_2	335543.Sfum_0927	1.21e-24	99.8	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,42PAH@68525|delta/epsilon subdivisions,2WKSM@28221|Deltaproteobacteria,2MS4X@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356,ko:K03503	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_848774_1	1158318.ATXC01000001_gene1014	4.52e-39	149.0	COG1185@1|root,COG1185@2|Bacteria,2G3IH@200783|Aquificae	200783|Aquificae	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_750636_1	398578.Daci_1287	7.5e-55	185.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2VJ2P@28216|Betaproteobacteria,4ACTM@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,HTH_17,SHOCT
k59_454443_1	398720.MED217_01565	1.43e-22	97.1	COG3507@1|root,COG3507@2|Bacteria,4NDUM@976|Bacteroidetes,1I00E@117743|Flavobacteriia,2XIVJ@283735|Leeuwenhoekiella	976|Bacteroidetes	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
k59_454443_2	1492738.FEM21_03750	1.18e-65	218.0	COG3507@1|root,COG3507@2|Bacteria,4NH4M@976|Bacteroidetes,1IIJ6@117743|Flavobacteriia,2NYGR@237|Flavobacterium	976|Bacteroidetes	G	Glycosyl hydrolases family 32 N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
k59_194020_1	338969.Rfer_1781	2.28e-73	230.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,4AAD7@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM sulfate ABC transporter, periplasmic sulfate-binding protein	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
k59_194020_2	1121937.AUHJ01000008_gene2084	7.37e-07	50.1	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,46440@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_357663_1	1122962.AULH01000011_gene1080	4.16e-84	259.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria,36X8G@31993|Methylocystaceae	28211|Alphaproteobacteria	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	hupS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_1009543_1	172045.KS04_08775	6.81e-88	266.0	COG1250@1|root,COG1250@2|Bacteria,4NGU8@976|Bacteroidetes,1HWQX@117743|Flavobacteriia,34PZ8@308865|Elizabethkingia	976|Bacteroidetes	I	Putative NAD(P)-binding	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_194021_1	111780.Sta7437_2844	6.46e-27	103.0	2E8NG@1|root,332ZQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_521935_1	1336245.JAGO01000015_gene1971	5.4e-26	108.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,1RRII@1236|Gammaproteobacteria	1236|Gammaproteobacteria	HP	(ABC) transporter	fhuC	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_879375_1	395493.BegalDRAFT_1449	4.08e-14	72.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,45ZT5@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_879375_2	1123354.AUDR01000001_gene2048	7.33e-22	90.9	COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,2VRNP@28216|Betaproteobacteria	28216|Betaproteobacteria	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_848785_1	1415780.JPOG01000001_gene3078	9.72e-06	45.1	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,1S8TD@1236|Gammaproteobacteria,1X7HX@135614|Xanthomonadales	135614|Xanthomonadales	P	PFAM small multidrug resistance protein	sugE	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
k59_848785_2	266834.SMc01460	1.42e-66	204.0	COG2128@1|root,COG2128@2|Bacteria,1RJ9Q@1224|Proteobacteria,2U96S@28211|Alphaproteobacteria,4BMV1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_31709_1	330214.NIDE2209	1.74e-76	242.0	COG0014@1|root,COG0014@2|Bacteria,3J0ET@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_97438_1	690850.Desaf_1608	2.57e-85	269.0	COG0569@1|root,COG1226@1|root,COG0569@2|Bacteria,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria,42NKU@68525|delta/epsilon subdivisions,2WIRH@28221|Deltaproteobacteria,2M9MG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_879379_1	13690.CP98_03536	5.11e-19	91.3	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TT4X@28211|Alphaproteobacteria,2K0E1@204457|Sphingomonadales	204457|Sphingomonadales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_587264_1	497964.CfE428DRAFT_6644	4.32e-48	170.0	COG1657@1|root,COG1657@2|Bacteria,46TK5@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Squalene-hopene cyclase N-terminal domain	sqhC	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
k59_750655_1	1097668.BYI23_C012260	7.81e-101	303.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2W1F0@28216|Betaproteobacteria,1K8H0@119060|Burkholderiaceae	28216|Betaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_322528_1	748247.AZKH_3094	4.59e-104	319.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KVAY@206389|Rhodocyclales	206389|Rhodocyclales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_618815_1	1163617.SCD_n01286	1.88e-69	223.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria	28216|Betaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_322530_1	111781.Lepto7376_0248	1.23e-103	307.0	COG3541@1|root,COG3541@2|Bacteria,1G3R1@1117|Cyanobacteria,1H74A@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Nucleotidyltransferase	-	-	-	ko:K07074	-	-	-	-	ko00000	-	-	-	Nuc-transf
k59_63205_1	395495.Lcho_4123	1.1e-94	301.0	COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria,1KN2G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_879387_1	330214.NIDE4146	3.09e-93	278.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
k59_879387_2	330214.NIDE4147	0.000201	47.8	COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
k59_979106_1	157783.LK03_01570	9.88e-96	292.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the EPSP synthase family. MurA subfamily	murA	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_979106_2	265072.Mfla_0247	4.23e-40	138.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,2KM3E@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
k59_521960_1	330214.NIDE0423	9.35e-37	136.0	COG0128@1|root,COG0128@2|Bacteria,3J0BZ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_521960_2	1118054.CAGW01000071_gene1865	1.51e-56	185.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,4HFZE@91061|Bacilli,26RJ0@186822|Paenibacillaceae	91061|Bacilli	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
k59_388981_1	335543.Sfum_0418	3.52e-10	59.7	COG1259@1|root,COG1259@2|Bacteria,1RFFV@1224|Proteobacteria,42SCI@68525|delta/epsilon subdivisions,2WPWT@28221|Deltaproteobacteria,2MQHM@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
k59_388981_2	330214.NIDE2752	1.91e-34	123.0	COG1259@1|root,COG1259@2|Bacteria,3J0RC@40117|Nitrospirae	2|Bacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03617,ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
k59_777668_1	395492.Rleg2_5111	7.41e-26	105.0	COG2370@1|root,COG2370@2|Bacteria,1PPXD@1224|Proteobacteria,2V2C6@28211|Alphaproteobacteria,4BI58@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ
k59_777668_2	395492.Rleg2_5110	8.29e-83	251.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,4B7VB@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	hupE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
k59_777668_3	990285.RGCCGE502_16365	1.27e-92	280.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,4BA0J@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_685395_1	585529.HMPREF0291_10160	1.12e-12	73.9	COG1840@1|root,COG1840@2|Bacteria,2I8D6@201174|Actinobacteria,22M1R@1653|Corynebacteriaceae	201174|Actinobacteria	P	ABC transporter, solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_946306_1	404589.Anae109_1579	3.61e-115	336.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2YVSU@29|Myxococcales	28221|Deltaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_31748_1	247639.MGP2080_09878	1.68e-19	84.0	COG2128@1|root,COG2128@2|Bacteria,1PMH5@1224|Proteobacteria	1224|Proteobacteria	S	Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_31748_2	1121459.AQXE01000008_gene786	0.000323	46.2	COG0346@1|root,COG0346@2|Bacteria,1PM7Y@1224|Proteobacteria,42RD3@68525|delta/epsilon subdivisions,2WNY7@28221|Deltaproteobacteria,2M92N@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_129442_1	1121937.AUHJ01000001_gene332	1.36e-71	226.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,464B7@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_129442_2	1121937.AUHJ01000001_gene333	1.06e-45	154.0	COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,467AZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	High frequency lysogenization protein HflD homolog	hflD	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562	-	ko:K07153	-	-	-	-	ko00000	-	-	-	DUF489
k59_454485_1	323848.Nmul_A0682	7.37e-116	350.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,372IA@32003|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter transmembrane region	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_31750_1	941449.dsx2_0537	4.39e-107	325.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2M8HN@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,Sigma54_activat
k59_618844_1	244582.JQAK01000001_gene745	1.22e-09	59.3	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,47FF7@766|Rickettsiales	766|Rickettsiales	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_256095_1	494416.AYXN01000023_gene674	1.39e-13	73.2	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RMPX@1236|Gammaproteobacteria,3NSP6@468|Moraxellaceae	1236|Gammaproteobacteria	S	Penicillin amidase	pvdQ	-	3.5.1.97	ko:K07116	-	-	-	-	ko00000,ko01000	-	-	-	Penicil_amidase
k59_419457_2	426355.Mrad2831_4989	3.56e-133	392.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,1JV47@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PrpF protein	-	-	-	ko:K09788	ko00640,map00640	-	R11264	RC03405	ko00000,ko00001,ko01000	-	-	-	PrpF
k59_652235_1	880072.Desac_2633	1.22e-95	285.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MQY5@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1010717_1	666681.M301_2040	4.78e-28	105.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2VRD3@28216|Betaproteobacteria,2KMSC@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
k59_1010717_2	1163617.SCD_n02636	1.45e-50	172.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_778698_1	1123504.JQKD01000013_gene1007	5.37e-89	270.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VH6G@28216|Betaproteobacteria,4ABRZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_455813_1	349163.Acry_1270	2.77e-23	97.8	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2VFXG@28211|Alphaproteobacteria,2JRH8@204441|Rhodospirillales	204441|Rhodospirillales	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_455813_2	349163.Acry_1270	1.54e-109	327.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2VFXG@28211|Alphaproteobacteria,2JRH8@204441|Rhodospirillales	204441|Rhodospirillales	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_484179_1	1095769.CAHF01000011_gene2526	6.3e-85	258.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VKIQ@28216|Betaproteobacteria,472K4@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	AAA domain	exeA2	-	-	ko:K02450,ko:K12283	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
k59_652245_1	1255043.TVNIR_3244	3.5e-107	315.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_652245_2	637389.Acaty_c2187	1.56e-25	98.2	COG0509@1|root,COG0509@2|Bacteria,1N2U9@1224|Proteobacteria,1SC71@1236|Gammaproteobacteria,2NCVY@225057|Acidithiobacillales	225057|Acidithiobacillales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_195292_1	436308.Nmar_1728	4.94e-106	308.0	COG0638@1|root,arCOG00970@2157|Archaea,41T1N@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
k59_540442_1	420324.KI911947_gene5611	1.16e-27	117.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria,1JRWM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_227616_2	376733.IT41_17680	5.26e-31	114.0	COG1226@1|root,32YV7@2|Bacteria,1N7MV@1224|Proteobacteria,2VB08@28211|Alphaproteobacteria,2PXXX@265|Paracoccus	28211|Alphaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_323771_1	502025.Hoch_0001	1.06e-33	132.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2WJAT@28221|Deltaproteobacteria,2YTT2@29|Myxococcales	28221|Deltaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_880606_1	330214.NIDE3258	3.93e-70	218.0	COG0655@1|root,COG0655@2|Bacteria,3J192@40117|Nitrospirae	40117|Nitrospirae	S	NADPH-dependent FMN reductase	wrbA	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
k59_163176_1	1229909.NSED_09745	4.9e-119	354.0	COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_256150_1	1232437.KL662001_gene4651	2.38e-128	383.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2WKSV@28221|Deltaproteobacteria,2MHUQ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_912087_1	1247649.D560_1890	2.39e-14	71.2	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VHWQ@28216|Betaproteobacteria,3T1X4@506|Alcaligenaceae	28216|Betaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_912087_2	264198.Reut_A0754	1.99e-27	107.0	COG1309@1|root,COG1309@2|Bacteria,1MWKF@1224|Proteobacteria,2W9FC@28216|Betaproteobacteria,1KD6U@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_390502_1	521011.Mpal_2574	6.64e-05	45.1	COG3384@1|root,arCOG01730@2157|Archaea,2Y0BA@28890|Euryarchaeota	28890|Euryarchaeota	E	PFAM Extradiol ring-cleavage dioxygenase, class III	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
k59_390502_2	1168059.KB899087_gene3481	9.36e-45	150.0	COG2259@1|root,COG2259@2|Bacteria,1N06A@1224|Proteobacteria,2U6MK@28211|Alphaproteobacteria,3EZKU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_390502_3	936455.KI421499_gene7564	1.28e-23	98.6	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,3JR80@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009987,GO:0010212,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_163205_1	671143.DAMO_0818	1.86e-38	141.0	COG3005@1|root,COG3005@2|Bacteria,2NQ90@2323|unclassified Bacteria	2|Bacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	ko:K08354	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko02000	5.A.3.5	-	-	Cytochrome_C554,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1
k59_390511_1	338969.Rfer_4025	1.96e-69	213.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2VSH3@28216|Betaproteobacteria,4AEBC@80864|Comamonadaceae	28216|Betaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
k59_390511_2	1095769.CAHF01000022_gene199	4.65e-08	52.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VRJ0@28216|Betaproteobacteria,4772C@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
k59_620078_1	330214.NIDE2567	1.1e-90	276.0	COG0436@1|root,COG0436@2|Bacteria,3J0EV@40117|Nitrospirae	40117|Nitrospirae	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_620078_2	330214.NIDE2566	7.93e-52	167.0	COG0669@1|root,COG0669@2|Bacteria,3J0MF@40117|Nitrospirae	40117|Nitrospirae	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_64578_2	388051.AUFE01000057_gene4908	6.83e-40	141.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2VIAK@28216|Betaproteobacteria,1JZQ7@119060|Burkholderiaceae	28216|Betaproteobacteria	FL	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ada	GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,HTH_AraC,Methyltransf_1N
k59_880639_1	1499967.BAYZ01000172_gene5771	1.18e-63	209.0	COG1301@1|root,COG1301@2|Bacteria,2NP6X@2323|unclassified Bacteria	2|Bacteria	U	Sodium:dicarboxylate symporter family	gltT	-	-	-	-	-	-	-	-	-	-	-	SDF
k59_484262_1	323848.Nmul_A2507	7.29e-54	175.0	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2VSHR@28216|Betaproteobacteria,3732Y@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
k59_795512_2	945713.IALB_1371	1.58e-50	171.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_755533_2	1080067.BAZH01000003_gene3692	0.000112	43.5	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,1RMVF@1236|Gammaproteobacteria,3WXSJ@544|Citrobacter	1236|Gammaproteobacteria	E	Orn/Lys/Arg decarboxylase, N-terminal domain	adiA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0006873,GO:0006885,GO:0008144,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019725,GO:0019752,GO:0019842,GO:0030003,GO:0030004,GO:0030170,GO:0030641,GO:0036094,GO:0042592,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0045852,GO:0046395,GO:0048037,GO:0048878,GO:0050662,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:0098771,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_4483	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
k59_168974_2	1163617.SCD_n02456	1.2e-28	111.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Tyrosine recombinase xerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1014493_1	1122137.AQXF01000005_gene1288	4.61e-39	144.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2TSPJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_364528_1	351160.RRC447	2.01e-66	211.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_233389_1	1380394.JADL01000001_gene2546	8.48e-05	49.7	COG1295@1|root,COG1295@2|Bacteria,1R9UY@1224|Proteobacteria,2U3WV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM YihY family protein (not ribonuclease BN)	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_429804_1	243233.MCA0415	3.31e-15	80.5	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1XE56@135618|Methylococcales	135618|Methylococcales	O	TIGRFAM Cytochrome c-type biogenesis protein CcmI	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	-
k59_854255_1	626418.bglu_1g04970	1.62e-108	322.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,1K06J@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_560873_1	1500257.JQNM01000014_gene2913	7.66e-50	175.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TRHJ@28211|Alphaproteobacteria,4B8QN@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	MA20_44090	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_785360_1	1144310.PMI07_005606	2.16e-35	127.0	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2U0PK@28211|Alphaproteobacteria,4BK1F@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	PFAM class II aldolase adducin family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_785360_2	1231391.AMZF01000063_gene1103	1.11e-52	174.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2VQBC@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Class II aldolase adducin family protein	fucA	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_724014_1	395493.BegalDRAFT_1632	3.45e-88	265.0	COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,1RR82@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
k59_332113_1	936573.HMPREF1147_0476	1.14e-74	234.0	COG1239@1|root,COG1239@2|Bacteria,1U356@1239|Firmicutes,4H2X9@909932|Negativicutes	909932|Negativicutes	H	Magnesium chelatase, subunit ChlI	chlI	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase
k59_724017_1	1304883.KI912532_gene1972	3.19e-131	384.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales	206389|Rhodocyclales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_984765_1	1229909.NSED_05590	3.3e-11	63.5	arCOG03622@1|root,arCOG03622@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_560883_2	1229909.NSED_06935	1.41e-127	369.0	COG0157@1|root,arCOG01482@2157|Archaea,41SHI@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Involved in the catabolism of quinolinic acid (QA)	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_984766_1	1280946.HY29_04005	2.06e-20	95.5	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTUW@28211|Alphaproteobacteria,43WD3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_625924_1	882083.SacmaDRAFT_5688	1.33e-24	108.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DZ2U@85010|Pseudonocardiales	201174|Actinobacteria	I	AMP-forming long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_103693_1	1454004.AW11_04058	4.5e-61	202.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,1KPQ0@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_103693_2	580332.Slit_2733	8.12e-104	305.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,44VEN@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A,Sugar-bind
k59_103693_3	582744.Msip34_0666	7.37e-46	154.0	COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,2KN7I@206350|Nitrosomonadales	206350|Nitrosomonadales	T	Phosphoglycerate mutase family	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_920050_1	1121405.dsmv_0381	1.37e-82	262.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria,2MHX0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_495717_1	405948.SACE_4653	7.34e-36	140.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DZ55@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator, LuxR family	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	AAA_22,GerE,NB-ARC,Pkinase,TPR_12
k59_593394_1	240015.ACP_1684	1.89e-30	126.0	COG0768@1|root,COG0768@2|Bacteria,3Y3MX@57723|Acidobacteria,2JHRD@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_952498_1	748247.AZKH_0003	1.79e-82	270.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,2KUE2@206389|Rhodocyclales	206389|Rhodocyclales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_201535_1	864051.BurJ1DRAFT_4986	1.15e-36	133.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VRBJ@28216|Betaproteobacteria,1KKWN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_103706_1	426355.Mrad2831_0399	9.24e-22	103.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,1JSTD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Histidine kinase	fixL	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_9
k59_202534_2	1408224.SAMCCGM7_c4023	3.3e-130	385.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TRET@28211|Alphaproteobacteria,4B7K6@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate	-	-	-	ko:K11103	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.23.1.3,2.A.23.1.6,2.A.23.1.7	-	-	SDF
k59_887605_1	525904.Tter_0266	1.9e-19	94.0	COG4262@1|root,COG4262@2|Bacteria,2NS3W@2323|unclassified Bacteria	2|Bacteria	S	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,Spermine_synth
k59_333155_1	62928.azo3488	2.6e-73	229.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales	206389|Rhodocyclales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
k59_785700_1	671143.DAMO_1537	1.13e-11	65.9	COG1653@1|root,COG1653@2|Bacteria,2NP9E@2323|unclassified Bacteria	2|Bacteria	G	Bacterial extracellular solute-binding protein	thuE	-	-	ko:K02027,ko:K10236	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
k59_785700_2	1114970.PSF113_2510	4.74e-28	112.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,1RZC6@1236|Gammaproteobacteria,1YSR0@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	thuF	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
k59_430818_2	123899.JPQP01000001_gene1737	8.14e-33	124.0	COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2VJB5@28216|Betaproteobacteria,3T9IX@506|Alcaligenaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_39377_1	864702.OsccyDRAFT_3828	6.79e-139	409.0	COG1215@1|root,COG1215@2|Bacteria,1G1PN@1117|Cyanobacteria,1H9ZX@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
k59_462516_1	485913.Krac_0317	3.91e-41	150.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_921115_1	593907.Celgi_0898	2.01e-73	237.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_823191_1	1500897.JQNA01000001_gene5623	1.23e-43	157.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VI6D@28216|Betaproteobacteria,1K5TM@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_170054_1	536233.CLO_1769	9.12e-44	162.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36EFE@31979|Clostridiaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_823205_1	330214.NIDE2542	1.48e-80	250.0	COG0505@1|root,COG0505@2|Bacteria,3J0CS@40117|Nitrospirae	40117|Nitrospirae	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_430842_1	159087.Daro_0112	6.35e-81	251.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2VH8Q@28216|Betaproteobacteria,2KURV@206389|Rhodocyclales	206389|Rhodocyclales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_72325_1	1123376.AUIU01000011_gene1018	3.92e-72	232.0	COG0119@1|root,COG0119@2|Bacteria,3J0DC@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_72325_2	667014.Thein_0303	4.84e-08	53.5	COG0527@1|root,COG0527@2|Bacteria,2GGWG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_594472_1	1117647.M5M_09065	2.25e-33	120.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,1J5ZY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_365593_1	196367.JNFG01000015_gene3899	1.26e-68	227.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,1JZX3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-coa dehydrogenase	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_72335_1	595537.Varpa_5908	1.19e-10	63.2	COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,2VVSJ@28216|Betaproteobacteria,4AF3V@80864|Comamonadaceae	28216|Betaproteobacteria	NU	Belongs to the N-Me-Phe pilin family	pilA	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
k59_594483_1	1191523.MROS_2223	9.39e-138	400.0	COG0473@1|root,COG0473@2|Bacteria	2|Bacteria	CE	3-isopropylmalate dehydrogenase activity	dlpA	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh,MoCF_biosynth,RraA-like
k59_887662_1	713586.KB900536_gene2597	5.6e-26	109.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_333209_1	1540221.JQNI01000002_gene1880	1.57e-22	97.8	COG0596@1|root,COG0596@2|Bacteria,1WKZP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Serine aminopeptidase, S33	yfhM	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_462557_1	330214.NIDE0190	2.48e-43	152.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	ycgE	-	-	ko:K21089,ko:K21972,ko:K22491	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
k59_267995_1	742159.HMPREF0004_2758	3.38e-69	229.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2VHFA@28216|Betaproteobacteria,3T1C6@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0003674,GO:0003824,GO:0004362,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0022900,GO:0031974,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0098869,GO:1901360,GO:1990748	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_855353_1	1459636.NTE_00800	1e-84	270.0	COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_365627_1	864073.HFRIS_012424	1.97e-28	111.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,472UW@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_365627_2	1122201.AUAZ01000056_gene39	2.28e-19	83.6	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,4678W@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0019842,GO:0031406,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051870,GO:0051871,GO:0055114,GO:0070401,GO:0070402,GO:0072341,GO:0097159,GO:1901265,GO:1901363	1.5.1.3	ko:K00287,ko:K18590	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	br01600,ko00000,ko00001,ko00002,ko01000,ko01504	-	-	iECBD_1354.ECBD_3567,iECDH1ME8569_1439.ECDH1ME8569_0047,iECNA114_1301.ECNA114_0036,iEcDH1_1363.EcDH1_3551,iEcSMS35_1347.EcSMS35_0050,iG2583_1286.G2583_0050,iJN746.PP_5132,iNRG857_1313.NRG857_00250,iUMN146_1321.UM146_23020	DHFR_1
k59_365628_1	555779.Dthio_PD3171	2.75e-24	106.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2WJF5@28221|Deltaproteobacteria,2M9E2@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	CBS domain containing protein	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_137505_1	641491.DND132_1953	6.8e-15	77.4	COG5434@1|root,COG5434@2|Bacteria,1PGI5@1224|Proteobacteria,435Q3@68525|delta/epsilon subdivisions,2X046@28221|Deltaproteobacteria,2MAEU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_104785_1	439235.Dalk_5087	3.93e-96	291.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_365629_1	1268622.AVS7_04200	6.1e-10	60.1	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,4ABUZ@80864|Comamonadaceae	28216|Betaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_365629_2	1095769.CAHF01000007_gene1653	8.46e-64	206.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria,472G7@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aminotransferase class-V	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_397422_2	580332.Slit_0971	8e-29	106.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,2VTX5@28216|Betaproteobacteria,44W49@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_397422_3	1266925.JHVX01000003_gene530	6.1e-97	288.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,372E4@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_823272_2	485915.Dret_1587	4.27e-25	99.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2MC0G@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_692676_1	1504672.669787666	3.36e-36	136.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,2VMZ8@28216|Betaproteobacteria,4AHWK@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_300199_1	1370122.JHXQ01000001_gene527	6.6e-16	82.8	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TTPD@28211|Alphaproteobacteria,4B9P0@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	glutamine synthetase	glnA	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_594518_1	1380394.JADL01000009_gene3424	8.92e-89	269.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,2JQ3B@204441|Rhodospirillales	204441|Rhodospirillales	ET	general L-amino acid-binding periplasmic protein AapJ	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k59_202612_1	305700.B447_12489	1.34e-39	132.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2VTZH@28216|Betaproteobacteria,2KWX1@206389|Rhodocyclales	206389|Rhodocyclales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_202612_2	1000565.METUNv1_00622	6.04e-26	105.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,2KUW2@206389|Rhodocyclales	206389|Rhodocyclales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_855377_1	879212.DespoDRAFT_03190	4.06e-61	199.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42PEQ@68525|delta/epsilon subdivisions,2WKWX@28221|Deltaproteobacteria,2MHQR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
k59_300214_1	794903.OPIT5_25320	1.16e-33	133.0	COG1196@1|root,COG1196@2|Bacteria,46TX7@74201|Verrucomicrobia	74201|Verrucomicrobia	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_985874_1	1121374.KB891576_gene312	3.42e-38	143.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_823296_1	1115632.JAFW01000001_gene4290	4.71e-14	77.4	COG1914@1|root,COG1914@2|Bacteria,2GMUT@201174|Actinobacteria	201174|Actinobacteria	P	H( )-stimulated, divalent metal cation uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_562067_1	866536.Belba_3137	7.22e-52	178.0	COG1570@1|root,COG1570@2|Bacteria,4NE64@976|Bacteroidetes,47NEW@768503|Cytophagia	976|Bacteroidetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_660121_1	882.DVU_3127	9.94e-57	193.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,42PHS@68525|delta/epsilon subdivisions,2X5NU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_341974_1	187272.Mlg_0750	2.37e-45	155.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales	135613|Chromatiales	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_341974_2	1173022.Cri9333_3259	2.51e-120	360.0	COG0306@1|root,COG0306@2|Bacteria,1G4MA@1117|Cyanobacteria,1HE8Q@1150|Oscillatoriales	1117|Cyanobacteria	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_341974_3	1237149.C900_04573	4.29e-184	517.0	COG0500@1|root,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,47MZ1@768503|Cytophagia	976|Bacteroidetes	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
k59_341974_4	522306.CAP2UW1_2826	4.48e-162	477.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KQAC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	SNARE associated Golgi protein	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_735118_1	1266925.JHVX01000005_gene1938	5.36e-27	103.0	COG3312@1|root,COG3312@2|Bacteria,1R3CS@1224|Proteobacteria,2WIGV@28216|Betaproteobacteria,374P5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_735118_2	1387312.BAUS01000004_gene1491	9.58e-37	132.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KKB3@206350|Nitrosomonadales	206350|Nitrosomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_374851_1	1292020.H483_0118470	1.39e-60	203.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_274629_1	381666.H16_B0159	1.11e-81	259.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1K0B4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_440124_1	640081.Dsui_1690	9.46e-86	260.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria,2KVQ8@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_440124_2	580332.Slit_2580	9.41e-17	80.1	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,44VA1@713636|Nitrosomonadales	28216|Betaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_506513_2	640512.BC1003_1040	6.12e-24	100.0	COG1215@1|root,COG1215@2|Bacteria,1RBGS@1224|Proteobacteria,2VQWI@28216|Betaproteobacteria,1K6HG@119060|Burkholderiaceae	28216|Betaproteobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_604059_1	765420.OSCT_2617	7.13e-43	152.0	COG2008@1|root,COG2008@2|Bacteria,2G5XG@200795|Chloroflexi,374UV@32061|Chloroflexia	32061|Chloroflexia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_896744_1	240016.ABIZ01000001_gene1742	5.57e-49	172.0	COG1861@1|root,COG1861@2|Bacteria,46UVT@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_82155_1	754252.PFREUD_15940	6.16e-11	63.2	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4DNH6@85009|Propionibacteriales	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	sucB	GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008289,GO:0009405,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0030312,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0043177,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0051704,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_82155_2	632518.Calow_0561	6.64e-29	112.0	COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia,42FUN@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_931020_1	644282.Deba_1215	1.26e-81	252.0	COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2WIRR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_16788_1	330214.NIDE1125	8.1e-64	208.0	COG0301@1|root,COG0301@2|Bacteria	2|Bacteria	H	tRNA thio-modification	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	THUMP,ThiI
k59_506535_1	436308.Nmar_1715	9.12e-20	86.3	COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
k59_147179_1	1433126.BN938_2354	1.48e-44	164.0	COG1193@1|root,COG1193@2|Bacteria,4NFE6@976|Bacteroidetes,2FMKP@200643|Bacteroidia,22U0D@171550|Rikenellaceae	976|Bacteroidetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
k59_309034_1	85643.Tmz1t_1658	2.1e-99	309.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,2KVQH@206389|Rhodocyclales	206389|Rhodocyclales	I	Acetyl-coenzyme A synthetase N-terminus	acsA	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_342772_1	1219581.HMPREF1628_04610	3.49e-47	168.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,4D83M@85005|Actinomycetales	201174|Actinobacteria	P	ABC transporter permease	-	-	-	ko:K02025,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
k59_82182_1	395493.BegalDRAFT_2506	1.09e-64	209.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,4609F@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_82182_2	1385517.N800_02635	4.34e-51	179.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales	135614|Xanthomonadales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_211984_1	351607.Acel_0409	1.08e-06	53.1	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4ERYE@85013|Frankiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE25	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249	ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_211984_2	1395571.TMS3_0108925	2.24e-20	91.7	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,1RN0D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	required for the utilization of tricarballylate as a carbon and energy source by S. enterica	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_374887_1	391009.Tmel_0803	1.88e-10	64.3	COG1449@1|root,COG4945@1|root,COG1449@2|Bacteria,COG4945@2|Bacteria,2GC51@200918|Thermotogae	200918|Thermotogae	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Glucodextran_C,Glyco_hydro_57
k59_896770_1	439235.Dalk_2505	7.19e-145	421.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MI5G@213118|Desulfobacterales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_309044_1	945713.IALB_0203	1.82e-110	325.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	f42a	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_82187_1	83406.HDN1F_07520	8.15e-60	207.0	COG0439@1|root,COG0511@1|root,COG0439@2|Bacteria,COG0511@2|Bacteria,1N71M@1224|Proteobacteria,1RYJ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0439 Biotin carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_864789_1	987059.RBXJA2T_03011	4.35e-40	148.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,1KKB8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_864789_2	228410.NE1834	2.07e-53	182.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,3720Q@32003|Nitrosomonadales	28216|Betaproteobacteria	C	TrkA-N domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_764371_1	1121948.AUAC01000005_gene2059	3.91e-13	70.1	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,43WCY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	D	Chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_833318_2	661478.OP10G_3688	1.16e-17	85.9	arCOG06766@1|root,2Z87F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_995248_2	1123368.AUIS01000031_gene1423	9.57e-49	162.0	COG0737@1|root,COG0737@2|Bacteria	2|Bacteria	F	nucleotide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_212001_1	1288494.EBAPG3_4360	4.68e-119	351.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,372BQ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_636554_1	1232410.KI421425_gene1552	4.25e-44	163.0	COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_896780_2	1123487.KB892834_gene3056	1.68e-100	294.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2VIFV@28216|Betaproteobacteria,2KUW6@206389|Rhodocyclales	206389|Rhodocyclales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_789105_1	330214.NIDE3772	5.01e-55	176.0	COG1278@1|root,COG1544@1|root,COG1278@2|Bacteria,COG1544@2|Bacteria	2|Bacteria	J	regulation of translation	raiA	-	-	ko:K03704,ko:K05809	-	-	-	-	ko00000,ko03000,ko03009	-	-	-	CSD,Ribosomal_S30AE
k59_147217_1	977880.RALTA_B0169	8.25e-05	43.9	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1K0B4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_147217_2	748247.AZKH_4235	1.28e-29	107.0	2END2@1|root,33G0J@2|Bacteria,1NIFI@1224|Proteobacteria,2VVU7@28216|Betaproteobacteria,2KZCF@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_179727_1	765914.ThisiDRAFT_0482	8.06e-103	308.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1WWHV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_440193_1	395494.Galf_1865	5.68e-66	226.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,44VAG@713636|Nitrosomonadales	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_735195_1	85643.Tmz1t_2192	5.74e-79	262.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,2KV3S@206389|Rhodocyclales	206389|Rhodocyclales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_147226_1	288000.BBta_3104	8.39e-54	185.0	COG1680@1|root,COG1680@2|Bacteria,1PDR2@1224|Proteobacteria,2U487@28211|Alphaproteobacteria,3JXAT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_604130_1	1459636.NTE_00173	1.63e-87	268.0	COG0053@1|root,arCOG01480@2157|Archaea	2157|Archaea	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_995267_1	296591.Bpro_2263	1.12e-17	76.3	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,4AE6H@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_995267_2	519989.ECTPHS_02801	3.86e-85	266.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales	135613|Chromatiales	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_636569_1	1144275.COCOR_04475	6.2e-52	177.0	COG1075@1|root,COG1075@2|Bacteria,1R88U@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
k59_896797_1	412597.AEPN01000093_gene1302	0.000861	41.2	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2PVW6@265|Paracoccus	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_896797_2	868595.Desca_2487	8.46e-74	231.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia,261FY@186807|Peptococcaceae	186801|Clostridia	Q	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_374935_1	1038858.AXBA01000014_gene2190	2.96e-141	416.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,3EYG3@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	dihydroxy-acid dehydratase activity	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_896800_1	62928.azo1092	5.09e-73	242.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KV42@206389|Rhodocyclales	206389|Rhodocyclales	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_242139_1	760192.Halhy_5287	2.35e-83	269.0	COG1529@1|root,COG1529@2|Bacteria,4NFF5@976|Bacteroidetes,1IVK4@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.17.1.4,1.2.5.3	ko:K03520,ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_440217_1	1144307.PMI04_00515	1.06e-83	271.0	COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,2TTR0@28211|Alphaproteobacteria,2K3IN@204457|Sphingomonadales	204457|Sphingomonadales	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_506603_1	305900.GV64_06205	0.000598	41.6	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1XJPQ@135619|Oceanospirillales	135619|Oceanospirillales	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_506603_2	1444309.JAQG01000029_gene2473	5.25e-45	155.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,4HAV5@91061|Bacilli,26QHC@186822|Paenibacillaceae	91061|Bacilli	S	metallophosphoesterase	ymdB	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K02029,ko:K02030,ko:K09769	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	YmdB
k59_342842_1	1451261.AS96_06015	1.1e-07	55.8	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4FNUE@85023|Microbacteriaceae	201174|Actinobacteria	T	Forkhead associated domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_440227_1	316056.RPC_3477	9.87e-06	53.1	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,3JSIF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	MA20_31000	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_963673_2	67275.JOAP01000037_gene3024	1.79e-11	65.5	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria	201174|Actinobacteria	IQ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458,ko:K21789	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119,R11671	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_49066_1	420662.Mpe_A1043	1.91e-76	254.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ1H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	nolG	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_896822_1	85643.Tmz1t_2648	2.83e-64	217.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_571921_2	399739.Pmen_3071	1.09e-21	98.6	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria,1YFFN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_636613_1	497321.C664_18192	1.1e-111	335.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,2KVEH@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_571923_2	1472716.KBK24_0133885	6.99e-16	72.0	2C19F@1|root,32ZRH@2|Bacteria,1NYS5@1224|Proteobacteria,2W3DV@28216|Betaproteobacteria,1KHMK@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_864876_1	1121447.JONL01000001_gene838	8.53e-48	169.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2M8RK@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_764448_1	1028800.RG540_CH00970	7.96e-11	61.6	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,4BDWB@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	metE	-	2.1.1.14,4.4.1.23	ko:K00549,ko:K22363	ko00270,ko00450,ko00625,ko01100,ko01110,ko01230,map00270,map00450,map00625,map01100,map01110,map01230	M00017	R04405,R09365,R11897,R11899	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_764448_2	469371.Tbis_2580	9.41e-28	112.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4E1PI@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_147279_1	395494.Galf_1318	5.02e-124	376.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,44V5V@713636|Nitrosomonadales	28216|Betaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_864880_1	269797.Mbar_A1660	5.81e-45	159.0	COG5476@1|root,arCOG09072@2157|Archaea,2XYJG@28890|Euryarchaeota	28890|Euryarchaeota	S	MlrC C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
k59_864880_2	1245469.S58_15210	1.43e-13	72.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria,3JRMI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	MA20_04810	-	3.5.1.82	ko:K01461	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_3
k59_670034_2	522306.CAP2UW1_0198	1.47e-74	232.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2VN83@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_82282_1	330214.NIDE3942	2.04e-100	304.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_702887_1	1175306.GWL_27450	1.17e-12	66.6	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,476HJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.25	ko:K13875	ko00053,ko01100,map00053,map01100	-	R02522	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
k59_702887_2	266265.Bxe_A4448	3.61e-36	135.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VHJB@28216|Betaproteobacteria,1K0EB@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM D-galactarate dehydratase Altronate hydrolase domain protein	-	-	4.2.1.42,4.2.1.7,4.4.1.24	ko:K01685,ko:K01708,ko:K16846	ko00040,ko00053,ko00270,ko01100,map00040,map00053,map00270,map01100	M00631	R01540,R05608,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_179799_2	1200792.AKYF01000017_gene5588	0.000152	44.7	COG2084@1|root,COG2084@2|Bacteria,1V6Q1@1239|Firmicutes,4HK1I@91061|Bacilli,26VXV@186822|Paenibacillaceae	91061|Bacilli	I	NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_2
k59_25263_1	1157708.KB907462_gene1030	2.05e-70	230.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2VTNQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_939711_1	264462.Bd1381	1.24e-06	55.8	COG0642@1|root,COG0784@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_448298_1	886293.Sinac_7468	5.4e-54	188.0	COG0515@1|root,COG0515@2|Bacteria,2IXG3@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_351156_1	595537.Varpa_5655	4.22e-35	132.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKCY@28216|Betaproteobacteria,4A9R1@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_678721_1	1049564.TevJSym_ag00660	3.13e-30	123.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PFAM von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	-
k59_57009_1	1485544.JQKP01000001_gene1044	8.65e-44	152.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VKFT@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
k59_90902_1	228410.NE2052	1.78e-166	473.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,372HU@32003|Nitrosomonadales	28216|Betaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_25288_1	1168034.FH5T_16345	1.07e-17	82.4	COG1132@1|root,COG1132@2|Bacteria,4NFF7@976|Bacteroidetes,2G2XQ@200643|Bacteroidia	976|Bacteroidetes	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_25288_2	1168034.FH5T_16350	2.61e-66	218.0	COG1132@1|root,COG1132@2|Bacteria,4NDY6@976|Bacteroidetes,2FQJD@200643|Bacteroidia	976|Bacteroidetes	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_351170_1	330214.NIDE1514	2.03e-103	313.0	COG0312@1|root,COG0312@2|Bacteria,3J0F9@40117|Nitrospirae	40117|Nitrospirae	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_580573_1	1348657.M622_16845	8.17e-95	284.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,2KUZJ@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_711521_1	1049564.TevJSym_ac01050	2.31e-71	233.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1J4P5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the GPI family	pgi	GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcSMS35_1347.EcSMS35_4486	PGI
k59_873154_1	1229909.NSED_06965	5.99e-55	184.0	arCOG08777@1|root,arCOG10350@1|root,arCOG08777@2157|Archaea,arCOG10350@2157|Archaea	2157|Archaea	C	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_972418_1	2340.JV46_14530	1.2e-80	263.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1J56P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_316696_1	519989.ECTPHS_03192	1.5e-39	133.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1WYBV@135613|Chromatiales	135613|Chromatiales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_477786_1	1408303.JNJJ01000163_gene1108	1e-35	138.0	COG3547@1|root,COG3547@2|Bacteria,1TRSB@1239|Firmicutes,4HDPK@91061|Bacilli,1ZAPJ@1386|Bacillus	91061|Bacilli	L	PFAM Transposase, IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_678748_1	1154860.SAG0136_09780	3.77e-18	84.7	COG1249@1|root,COG1249@2|Bacteria,1TQFH@1239|Firmicutes,4HCT8@91061|Bacilli	91061|Bacilli	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_412820_2	76114.ebA2656	1.44e-84	256.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2VGZ7@28216|Betaproteobacteria,2KUF1@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_580586_1	1125863.JAFN01000001_gene1039	1.17e-87	275.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_90922_1	987059.RBXJA2T_02125	1.08e-36	125.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,1KM7R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_90922_2	1265502.KB905956_gene119	4.85e-74	226.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2VHS6@28216|Betaproteobacteria,4A9NQ@80864|Comamonadaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_612531_1	265072.Mfla_2497	5.48e-113	336.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,2KM20@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_711531_2	1288826.MSNKSG1_15591	1.33e-39	143.0	COG0591@1|root,COG0591@2|Bacteria,1PKDE@1224|Proteobacteria,1RP4J@1236|Gammaproteobacteria,46AUG@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_122955_1	1123501.KB902280_gene420	7.15e-64	210.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	mccB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_122955_2	1123053.AUDG01000002_gene2829	1.97e-36	132.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,1RP85@1236|Gammaproteobacteria,1WY5H@135613|Chromatiales	135613|Chromatiales	I	enoyl-CoA hydratase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_90933_1	1449357.JQLK01000005_gene2448	7.38e-09	57.8	COG2801@1|root,COG2801@2|Bacteria,1WK3M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k59_90933_2	1280953.HOC_16032	4.86e-09	55.8	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_644909_1	1267535.KB906767_gene1660	6.3e-08	54.3	COG0337@1|root,COG0337@2|Bacteria,3Y2T4@57723|Acidobacteria,2JI0C@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	-	-	4.2.3.152	ko:K19969	ko00525,ko01130,map00525,map01130	M00814,M00815	R10937	RC03308	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_644909_2	1040989.AWZU01000092_gene1239	1.65e-43	154.0	COG1082@1|root,COG1082@2|Bacteria,1NHXC@1224|Proteobacteria,2U3WP@28211|Alphaproteobacteria,3JTQQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1024193_1	631454.N177_2123	2.2e-54	187.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,1JNDU@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_743962_1	1123368.AUIS01000008_gene2167	8.56e-82	251.0	COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,2NDIH@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
k59_122963_1	85643.Tmz1t_1421	6.78e-101	298.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,2KUBI@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483,ko:K07774	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_678772_1	933262.AXAM01000022_gene3241	6.73e-49	176.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_220254_1	1380391.JIAS01000011_gene5158	4.42e-47	153.0	2A2P0@1|root,30R1J@2|Bacteria,1RFQ3@1224|Proteobacteria,2U7RA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_792618_1	1287276.X752_06905	2.06e-07	57.8	COG3735@1|root,COG3735@2|Bacteria,1RBFT@1224|Proteobacteria,2U5YM@28211|Alphaproteobacteria,43I41@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	GumN family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_25339_1	323848.Nmul_A1751	6.29e-126	375.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,372EW@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_873190_1	187272.Mlg_1343	4.61e-43	156.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WWWR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_448372_1	269484.Ecaj_0289	2.95e-29	109.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2U72Q@28211|Alphaproteobacteria,47FH2@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_448372_2	3075.A0A087S9Z0	2.14e-42	147.0	COG0356@1|root,KOG4665@2759|Eukaryota,37J5M@33090|Viridiplantae,34IHJ@3041|Chlorophyta	3041|Chlorophyta	C	ATP synthase A chain	-	-	-	ko:K02126	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002,ko03029	3.A.2.1	-	-	ATP-synt_A
k59_711562_1	330214.NIDE1724	6.15e-84	267.0	COG5184@1|root,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin-like,DUF3494,Glug,TIG
k59_57064_1	264198.Reut_A3010	2.4e-96	286.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,1K0P4@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	paaF	-	4.2.1.17	ko:K01692,ko:K01715	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1003485_1	880072.Desac_2757	2.21e-38	130.0	COG0025@1|root,COG0025@2|Bacteria,1P10M@1224|Proteobacteria,431TY@68525|delta/epsilon subdivisions,2WWJK@28221|Deltaproteobacteria,2MS9K@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	NhaP-type Na H and K H	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1003485_2	706587.Desti_2898	1.22e-18	78.6	2APA5@1|root,31EC7@2|Bacteria,1RHMQ@1224|Proteobacteria,42UND@68525|delta/epsilon subdivisions,2WQK4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_873201_1	556268.OFAG_02377	3.94e-15	72.0	COG1918@1|root,COG1918@2|Bacteria,1NASN@1224|Proteobacteria,2VVSY@28216|Betaproteobacteria,4759I@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
k59_25354_2	83406.HDN1F_01370	1.19e-33	130.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1J4VF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_536483_1	1229909.NSED_09330	6.09e-45	151.0	COG1010@1|root,arCOG00647@2157|Archaea,41S6W@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.131	ko:K05934	ko00860,ko01100,map00860,map01100	-	R05180,R05809	RC00003,RC01293,RC03471	ko00000,ko00001,ko01000	-	-	-	TP_methylase
k59_536483_2	1229909.NSED_09335	1.39e-48	168.0	arCOG08764@1|root,arCOG08764@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_904820_1	1499967.BAYZ01000163_gene6592	1.34e-95	287.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
k59_904827_1	338963.Pcar_2557	4.65e-41	155.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,43UHA@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Bifunctional transglycosylase second domain	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_744006_1	338966.Ppro_2714	1.89e-07	58.2	COG2202@1|root,COG2203@1|root,COG3829@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,1PEPF@1224|Proteobacteria,439XC@68525|delta/epsilon subdivisions,2X1UM@28221|Deltaproteobacteria,43UUE@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,PAS_3
k59_123004_1	946483.Cenrod_0049	6.46e-47	158.0	COG3293@1|root,COG3293@2|Bacteria,1PE1I@1224|Proteobacteria,2VSHY@28216|Betaproteobacteria,4AJG2@80864|Comamonadaceae	28216|Betaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_123004_2	867845.KI911784_gene3167	1.19e-65	208.0	COG3293@1|root,COG3293@2|Bacteria,2G7ZQ@200795|Chloroflexi	200795|Chloroflexi	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_842198_1	269797.Mbar_A1918	2.14e-22	98.2	COG2120@1|root,arCOG03460@2157|Archaea,2XU80@28890|Euryarchaeota,2NAKP@224756|Methanomicrobia	224756|Methanomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k59_972486_1	240292.Ava_0231	3.57e-45	160.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,DDE_Tnp_ISAZ013,DUF3105,HTH_28,HTH_33
k59_873216_1	935948.KE386495_gene1509	3.2e-07	50.8	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,42EWJ@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_873216_2	568768.CM001975_gene3180	2.21e-21	87.8	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,2JED0@204037|Dickeya	1236|Gammaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_772086_1	318996.AXAZ01000001_gene4882	2.2e-113	340.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3JTY7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_939808_1	1123073.KB899241_gene2836	4.6e-20	94.4	COG4188@1|root,COG4188@2|Bacteria,1QUVG@1224|Proteobacteria,1T22C@1236|Gammaproteobacteria,1X4WW@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial virulence factor lipase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_bact_N
k59_772088_1	298386.PBPRA1295	2.47e-68	213.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,1RPKU@1236|Gammaproteobacteria,1XV1E@135623|Vibrionales	135623|Vibrionales	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_1024217_1	945713.IALB_0486	2.08e-45	167.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_612594_1	1238182.C882_2237	3.66e-64	205.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,2JS96@204441|Rhodospirillales	204441|Rhodospirillales	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1003530_1	420662.Mpe_A2942	3.88e-29	112.0	COG4795@1|root,COG4795@2|Bacteria,1N6ZJ@1224|Proteobacteria,2VURU@28216|Betaproteobacteria,1KMB4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	General secretion pathway protein	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
k59_123026_1	1229909.NSED_05490	2.32e-137	413.0	COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256,ko:K13722	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_220310_1	335283.Neut_1608	7.16e-223	639.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,371SW@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_904850_1	93220.LV28_11400	1.59e-129	376.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,1K3C5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SMART AAA ATPase	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
k59_515298_1	1121405.dsmv_1440	1.19e-88	281.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2MHMI@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_26312_1	1380347.JNII01000006_gene1415	3.37e-31	117.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_26312_2	1453500.AT05_05605	8.33e-38	139.0	COG0031@1|root,COG0031@2|Bacteria,4NDZ9@976|Bacteroidetes,1HX09@117743|Flavobacteriia	976|Bacteroidetes	E	Cystathionine beta-synthase	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_478621_1	436308.Nmar_1286	2.81e-125	366.0	COG0137@1|root,arCOG00112@2157|Archaea,41S6K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_123916_1	1121405.dsmv_0933	1.34e-38	139.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2WMP4@28221|Deltaproteobacteria,2MJMR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_613511_1	497965.Cyan7822_5258	3.42e-09	64.3	COG2202@1|root,COG5001@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1G0SY@1117|Cyanobacteria,3KGMH@43988|Cyanothece	1117|Cyanobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_221187_1	404589.Anae109_2897	7.75e-97	288.0	COG2086@1|root,COG2086@2|Bacteria,1R7VY@1224|Proteobacteria,42N0T@68525|delta/epsilon subdivisions,2WKSK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_712538_2	1089552.KI911559_gene1285	5.44e-85	268.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria,2JQAJ@204441|Rhodospirillales	204441|Rhodospirillales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_679791_1	1273125.Rrhod_1167	5.57e-71	233.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FV7A@85025|Nocardiaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_581627_1	1379270.AUXF01000002_gene1489	8.75e-42	144.0	COG1528@1|root,COG1528@2|Bacteria,1ZUFX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Rubrerythrin	-	-	1.16.3.1	ko:K22336	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_352194_1	323261.Noc_1881	1.78e-67	220.0	COG2204@1|root,COG2204@2|Bacteria,1NH9G@1224|Proteobacteria,1RRF2@1236|Gammaproteobacteria,1X04Q@135613|Chromatiales	135613|Chromatiales	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
k59_780186_2	1122611.KB903940_gene1819	1.25e-53	177.0	COG5564@1|root,COG5564@2|Bacteria,2GMW9@201174|Actinobacteria,4EGNZ@85012|Streptosporangiales	201174|Actinobacteria	S	Phosphoenolpyruvate hydrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	PEP_hydrolase
k59_541611_1	96561.Dole_3184	9.58e-144	426.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MIRV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_420958_2	1121448.DGI_1513	1.11e-70	216.0	COG3005@1|root,COG3005@2|Bacteria,1RI0B@1224|Proteobacteria,42T5J@68525|delta/epsilon subdivisions,2WNR2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cytochrome c nitrate reductase, small subunit	nrfH	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
k59_796130_1	713586.KB900536_gene376	3.61e-116	355.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_780217_1	330214.NIDE0613	2.02e-158	459.0	COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,3J0FM@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
k59_420983_1	257310.BB1573	3.07e-48	168.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,3T1XI@506|Alcaligenaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_325598_1	1000565.METUNv1_03721	1.2e-29	120.0	COG2946@1|root,COG2946@2|Bacteria,1RDKM@1224|Proteobacteria,2VNHY@28216|Betaproteobacteria,2KX1X@206389|Rhodocyclales	206389|Rhodocyclales	L	Replication initiation factor	-	-	-	-	-	-	-	-	-	-	-	-	Rep_trans
k59_325601_1	1163617.SCD_n01627	2.13e-91	291.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_283908_1	864051.BurJ1DRAFT_4624	3.12e-37	134.0	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2VNEM@28216|Betaproteobacteria,1KJMA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_913639_2	945713.IALB_1355	2.45e-44	162.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,TPR_16,TPR_2,TPR_6,TPR_8
k59_913643_1	1121441.AUCX01000028_gene330	9.76e-32	129.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S7S@68525|delta/epsilon subdivisions,2WNFR@28221|Deltaproteobacteria,2M9XW@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GGDEF,PAS,PAS_3,PAS_9,dCache_1
k59_325626_1	177437.HRM2_22490	4.21e-34	129.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,42N54@68525|delta/epsilon subdivisions,2WMGU@28221|Deltaproteobacteria,2MI8K@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
k59_421021_1	1207063.P24_03850	8.47e-155	447.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JVM4@204441|Rhodospirillales	204441|Rhodospirillales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_421021_2	305700.B447_19084	2.25e-14	73.2	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,2KUVG@206389|Rhodocyclales	206389|Rhodocyclales	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_541710_1	1266925.JHVX01000007_gene2421	3.88e-93	278.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2VN0K@28216|Betaproteobacteria,374M2@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_485667_1	338969.Rfer_1584	1.17e-30	111.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,2VS5T@28216|Betaproteobacteria,4AJE7@80864|Comamonadaceae	28216|Betaproteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_485667_2	436308.Nmar_1790	1.32e-36	134.0	COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_325657_1	32057.KB217478_gene6789	2.02e-65	206.0	COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria,1HMWG@1161|Nostocales	1117|Cyanobacteria	J	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_257640_1	1304883.KI912532_gene873	4.43e-32	127.0	COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,2KW9S@206389|Rhodocyclales	206389|Rhodocyclales	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
k59_257640_2	617140.AJZE01000077_gene1312	9.05e-17	80.1	COG0608@1|root,COG0608@2|Bacteria,1N37P@1224|Proteobacteria,1RQTR@1236|Gammaproteobacteria,1XTYY@135623|Vibrionales	135623|Vibrionales	L	single-stranded DNA 5'-3' exodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
k59_780313_1	1380394.JADL01000004_gene5909	2.69e-54	179.0	COG0346@1|root,COG0346@2|Bacteria,1MX75@1224|Proteobacteria,2TRQS@28211|Alphaproteobacteria,2JVNN@204441|Rhodospirillales	204441|Rhodospirillales	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_257650_1	1304883.KI912532_gene1809	5.37e-20	88.2	COG0834@1|root,COG0834@2|Bacteria,1RIGN@1224|Proteobacteria,2VMMR@28216|Betaproteobacteria,2KWHJ@206389|Rhodocyclales	206389|Rhodocyclales	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
k59_257650_2	1244869.H261_13009	2.64e-65	202.0	COG2010@1|root,COG2010@2|Bacteria,1RH1S@1224|Proteobacteria,2U0TD@28211|Alphaproteobacteria,2JWPX@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_541759_1	1382306.JNIM01000001_gene1777	6.45e-54	188.0	COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0454@2|Bacteria,2G5X3@200795|Chloroflexi	200795|Chloroflexi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_485716_1	1127673.GLIP_2140	2.05e-09	63.2	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,46557@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Universal stress protein	uspE	GO:0000302,GO:0001539,GO:0006928,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0034599,GO:0034614,GO:0034644,GO:0035690,GO:0040011,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071478,GO:0071482,GO:0071973,GO:0097237,GO:0097588,GO:0104004,GO:1901700,GO:1901701	-	ko:K14055	-	-	-	-	ko00000	-	-	-	Usp
k59_541770_1	93220.LV28_04495	3.48e-61	199.0	COG1073@1|root,COG1073@2|Bacteria,1QVY5@1224|Proteobacteria,2WGUH@28216|Betaproteobacteria,1K039@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,DLH,FSH1,Hydrolase_4
k59_541770_2	395495.Lcho_1522	2.66e-18	83.6	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,1KKFP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1029062_1	395495.Lcho_2364	1.97e-49	162.0	COG4564@1|root,COG4564@2|Bacteria,1RJP6@1224|Proteobacteria,2WEEN@28216|Betaproteobacteria,1KMQN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Cache_2	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
k59_796184_1	1266925.JHVX01000009_gene93	7.08e-42	152.0	COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,2VJXB@28216|Betaproteobacteria,37270@32003|Nitrosomonadales	28216|Betaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_257688_1	1128421.JAGA01000002_gene1276	8.54e-38	137.0	COG0177@1|root,COG0177@2|Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_541809_1	580332.Slit_2504	8.72e-67	222.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,44WEE@713636|Nitrosomonadales	28216|Betaproteobacteria	T	SMART CBS domain containing protein	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_913768_1	864073.HFRIS_019898	2.06e-148	446.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,472GD@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_541827_2	1121033.AUCF01000015_gene1385	1.48e-38	139.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,2JPS7@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_780398_1	290397.Adeh_2575	4.67e-10	62.4	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2YYND@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh,PDZ_2
k59_780398_2	886293.Sinac_5547	7.42e-43	158.0	COG0377@1|root,COG0649@1|root,COG0852@1|root,COG0377@2|Bacteria,COG0649@2|Bacteria,COG0852@2|Bacteria,2IYN8@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_913773_1	1392838.AWNM01000001_gene1718	2.05e-107	318.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,2W0I7@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_1029092_1	945713.IALB_2289	1.99e-27	103.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1029092_2	945713.IALB_2286	2.27e-30	120.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_541850_1	768671.ThimaDRAFT_2930	3.18e-59	190.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1S1WF@1236|Gammaproteobacteria,1X0A4@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_325818_1	1122929.KB908215_gene1124	6.41e-08	53.5	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	ttdR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_325818_2	999541.bgla_1g02650	3.16e-90	293.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1K37E@119060|Burkholderiaceae	28216|Betaproteobacteria	C	oxidoreductase	porG	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_796216_1	999541.bgla_2g26230	4.51e-89	268.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VKN4@28216|Betaproteobacteria,1K579@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_257767_1	1042375.AFPL01000008_gene3328	1.04e-31	123.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,1RTD3@1236|Gammaproteobacteria,468ZK@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Type II secretion system (T2SS), protein F	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_421184_1	945713.IALB_1061	1.06e-10	62.4	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria	2|Bacteria	J	polyribonucleotide nucleotidyltransferase activity	rpsA	GO:0005575,GO:0005576,GO:0018995,GO:0020003,GO:0030430,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0065010	1.17.7.4,2.7.11.1	ko:K02945,ko:K03527,ko:K07571,ko:K12132	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko01001,ko03011	-	-	-	S1
k59_421184_2	945713.IALB_1060	1.73e-106	320.0	COG0621@1|root,COG0621@2|Bacteria	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	yqeV	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
k59_541897_1	396588.Tgr7_2580	2.79e-107	325.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,1RMEB@1236|Gammaproteobacteria,1WVW5@135613|Chromatiales	135613|Chromatiales	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	-	-	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
k59_325834_1	864051.BurJ1DRAFT_2505	3.74e-51	175.0	COG1960@1|root,COG1960@2|Bacteria,1MW97@1224|Proteobacteria,2VHNT@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_325834_2	1123060.JONP01000005_gene5760	1.78e-33	125.0	COG2267@1|root,COG2267@2|Bacteria,1P7JV@1224|Proteobacteria,2TUWY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	MA20_38155	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Polyketide_cyc2
k59_780475_1	754477.Q7C_742	1.93e-18	80.1	COG1846@1|root,COG1846@2|Bacteria,1N0TY@1224|Proteobacteria,1SADN@1236|Gammaproteobacteria,463BK@72273|Thiotrichales	72273|Thiotrichales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
k59_780475_2	1173024.KI912149_gene4983	1.23e-64	205.0	COG1682@1|root,COG1682@2|Bacteria,1G23R@1117|Cyanobacteria,1JKDJ@1189|Stigonemataceae	1117|Cyanobacteria	GM	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
k59_780480_1	96561.Dole_0344	9.95e-62	210.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB-2	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_284041_1	1198452.Jab_1c24030	3.37e-91	286.0	COG4948@1|root,COG4948@2|Bacteria,1QVFR@1224|Proteobacteria	1224|Proteobacteria	M	Alpha-glucosidase	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
k59_799408_1	435590.BVU_3327	3.97e-06	54.3	COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,2FN49@200643|Bacteroidia,4AMYG@815|Bacteroidaceae	976|Bacteroidetes	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_287457_1	411684.HPDFL43_01995	0.000145	45.4	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,2V87Y@28211|Alphaproteobacteria,43PH8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_287457_2	1123501.KB902283_gene2287	1.9e-13	71.6	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family protein	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
k59_287459_1	1071679.BG57_30170	1.93e-74	233.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VM8B@28216|Betaproteobacteria,1K4WK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_287485_1	631362.Thi970DRAFT_01907	3.98e-95	300.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1032092_1	945713.IALB_1306	1.48e-11	69.7	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
k59_546855_2	1429916.X566_18495	2.06e-35	134.0	COG0477@1|root,COG2814@2|Bacteria,1P3S4@1224|Proteobacteria,2TVAQ@28211|Alphaproteobacteria,3JTFE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1032120_1	177437.HRM2_13730	3.07e-49	174.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MHYG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM malic	-	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_546882_1	159087.Daro_0339	7.93e-88	270.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,2KVBF@206389|Rhodocyclales	206389|Rhodocyclales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_546894_1	1265505.ATUG01000001_gene3492	0.00081	47.4	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG4936@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHWA@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,Response_reg
k59_799577_1	1415778.JQMM01000001_gene1253	1.42e-44	164.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1J4HR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the peptidase S16 family	ycbZ	-	-	ko:K04770	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_1032183_1	945713.IALB_0133	3.4e-37	139.0	COG4412@1|root,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PKD,Ricin_B_lectin
k59_546968_3	398512.JQKC01000006_gene754	3.39e-21	92.4	COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia,3WHBV@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_547027_1	314225.ELI_14900	1.99e-112	330.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_547030_1	1499967.BAYZ01000167_gene6748	1.74e-60	198.0	COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria	2|Bacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_1032255_1	1122194.AUHU01000010_gene3098	2.81e-88	278.0	COG3589@1|root,COG3589@2|Bacteria,1QWZC@1224|Proteobacteria,1RMUS@1236|Gammaproteobacteria,4668E@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Glycosyl-hydrolase 97 N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	GH97_C,GH97_N,Glyco_hydro_97
k59_287679_1	666681.M301_1273	2.12e-35	132.0	COG4972@1|root,COG4972@2|Bacteria,1N0HS@1224|Proteobacteria,2VQYY@28216|Betaproteobacteria,2KMQC@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Pilus assembly protein	-	-	-	ko:K12279	-	-	-	-	ko00000,ko02044	-	-	-	-
k59_287692_1	1121405.dsmv_0564	8.45e-79	265.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_287699_1	1192034.CAP_3050	3.69e-51	175.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2YUJQ@29|Myxococcales	28221|Deltaproteobacteria	NU	pilus assembly protein	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_287734_2	330214.NIDE3799	1.4e-107	313.0	COG2249@1|root,COG2249@2|Bacteria	2|Bacteria	K	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
k59_799824_1	1229205.BUPH_00005	3.65e-51	164.0	COG2128@1|root,COG2128@2|Bacteria,1RD2I@1224|Proteobacteria,2VV72@28216|Betaproteobacteria,1K788@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_983621_1	1049564.TevJSym_ae00660	2.71e-80	249.0	COG0398@1|root,COG0607@1|root,COG0398@2|Bacteria,COG0607@2|Bacteria,1MVF3@1224|Proteobacteria,1RSK1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	SNARE associated Golgi protein	ydjX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
k59_167824_1	396588.Tgr7_2193	1.48e-88	281.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2
k59_69996_1	436308.Nmar_1782	5.99e-98	298.0	COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
k59_722860_1	1380394.JADL01000003_gene4767	1.63e-113	342.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,2JUXN@204441|Rhodospirillales	204441|Rhodospirillales	EG	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_330947_1	1100720.ALKN01000030_gene1143	1.05e-92	286.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,4AAXN@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K14392	-	-	-	-	ko00000,ko02000	2.A.21.1	-	-	SSF
k59_167837_1	641491.DND132_2614	2.55e-68	221.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_4562_1	760117.JN27_07710	1.25e-120	362.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2VRSD@28216|Betaproteobacteria,475NM@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Thi4 family	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,DAO,NAD_binding_8
k59_395674_1	1121405.dsmv_2623	1.15e-35	136.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI1N@213118|Desulfobacterales	28221|Deltaproteobacteria	T	sigma-54 factor interaction domain-containing protein	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_395674_2	330214.NIDE3937	1.96e-47	170.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
k59_200404_1	1120950.KB892707_gene4662	2.11e-31	119.0	COG3181@1|root,COG3181@2|Bacteria,2IBJ1@201174|Actinobacteria,4DRRM@85009|Propionibacteriales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_200404_2	1411123.JQNH01000001_gene1859	2.73e-32	119.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TSPM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	MA20_43195	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_167861_1	56110.Oscil6304_4536	1.38e-27	108.0	COG0863@1|root,COG0863@2|Bacteria,1G4CX@1117|Cyanobacteria,1HE0Q@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_135275_1	266264.Rmet_1541	3.62e-123	369.0	COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,1KBJJ@119060|Burkholderiaceae	28216|Betaproteobacteria	IJ	Formyl transferase	hoxX	-	-	ko:K19640	-	-	-	-	ko00000,ko02022	-	-	-	ECH_1,Formyl_trans_C,Formyl_trans_N
k59_135275_2	1163617.SCD_n00773	4.45e-59	192.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2VH3K@28216|Betaproteobacteria	28216|Betaproteobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_494582_1	247634.GPB2148_1697	8.34e-39	147.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1J9C4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
k59_785000_1	1411123.JQNH01000001_gene1839	4.29e-88	274.0	COG1012@1|root,COG1012@2|Bacteria,1MY4N@1224|Proteobacteria,2TV5F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	paaN	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_200427_1	1123392.AQWL01000006_gene555	1.48e-15	78.2	COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,2WGMC@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Outer membrane receptor proteins mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_460920_2	1163617.SCD_n00675	2.64e-27	108.0	COG3064@1|root,COG3064@2|Bacteria,1RKZU@1224|Proteobacteria,2WGP5@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Cell division and transport-associated protein TolA	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
k59_265805_1	395494.Galf_2662	3.22e-181	511.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,44UYZ@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_265805_2	1218352.B597_013840	1.42e-13	67.4	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1Z308@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	K	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters	fis	GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
k59_265805_3	342113.DM82_2566	1.1e-27	110.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,1K3VV@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_951342_2	522306.CAP2UW1_1313	6e-25	98.6	COG4566@1|root,COG4566@2|Bacteria,1MZ8E@1224|Proteobacteria,2VYAI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Pfam Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_592289_1	595537.Varpa_2456	1.54e-95	296.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,4A9VY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_200439_2	880073.Calab_0218	2.74e-81	254.0	COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN746.PP_2215	Thiolase_C,Thiolase_N
k59_853205_1	1384054.N790_01965	1.3e-20	92.8	COG2199@1|root,COG3706@2|Bacteria,1R3YY@1224|Proteobacteria,1RZ1W@1236|Gammaproteobacteria,1X4T7@135614|Xanthomonadales	135614|Xanthomonadales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,GGDEF
k59_167896_1	1121948.AUAC01000003_gene2196	7.5e-05	45.4	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,43X83@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_167896_2	887327.HMPREF0476_1958	1.09e-23	92.8	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,2KRDC@206351|Neisseriales	206351|Neisseriales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_494612_2	857087.Metme_0760	2.23e-128	377.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XEFM@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_232505_1	365044.Pnap_3970	2.2e-11	63.5	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,4ACDU@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM NnrS family protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_232505_2	1454004.AW11_01059	1.23e-55	184.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria	1224|Proteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_983703_1	1502851.FG93_05036	1.76e-25	107.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3K2TC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_37322_1	1287276.X752_12730	6.96e-104	316.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,43GT5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	mccB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_298139_1	1380358.JADJ01000010_gene322	4.39e-07	57.4	COG2199@1|root,COG3706@2|Bacteria,1QXIS@1224|Proteobacteria,1T3CI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HDOD
k59_559805_1	365046.Rta_09180	5.09e-12	64.3	COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2WFRW@28216|Betaproteobacteria,4ADQJ@80864|Comamonadaceae	28216|Betaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_559805_2	247634.GPB2148_2826	1.04e-46	157.0	COG4405@1|root,COG4405@2|Bacteria,1QXXX@1224|Proteobacteria,1S7NI@1236|Gammaproteobacteria,1J6DY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
k59_886274_1	1380394.JADL01000012_gene824	4.53e-23	96.3	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2U0PK@28211|Alphaproteobacteria,2JWBN@204441|Rhodospirillales	204441|Rhodospirillales	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_886274_2	1286093.C266_07990	6.61e-64	206.0	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2VNER@28216|Betaproteobacteria,1K81W@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_37995_2	1207063.P24_06047	9.18e-24	94.4	2EIVU@1|root,33CM4@2|Bacteria,1NH4D@1224|Proteobacteria,2UJVJ@28211|Alphaproteobacteria,2JUJ0@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_37995_3	1380355.JNIJ01000010_gene1501	6.29e-11	61.6	2AJXY@1|root,31AM3@2|Bacteria,1NWTC@1224|Proteobacteria,2US0F@28211|Alphaproteobacteria,3K41X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_723649_1	1040989.AWZU01000035_gene1778	4.68e-47	168.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_266509_1	1298867.AUES01000008_gene5202	2.36e-48	179.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_429451_1	1123368.AUIS01000007_gene2733	9.65e-65	221.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2NBWY@225057|Acidithiobacillales	225057|Acidithiobacillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_461489_1	56107.Cylst_2614	7.99e-14	71.2	COG0667@1|root,COG0667@2|Bacteria,1G2Y9@1117|Cyanobacteria,1HJWG@1161|Nostocales	1117|Cyanobacteria	C	aldo keto reductase	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_461489_2	279714.FuraDRAFT_2296	8.84e-36	133.0	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,2VM0X@28216|Betaproteobacteria,2KSQI@206351|Neisseriales	206351|Neisseriales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_70838_1	1167006.UWK_01256	1.27e-82	271.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MHXW@213118|Desulfobacterales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_658552_1	880072.Desac_2382	1.05e-127	377.0	COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,42MUQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	Sodium calcium exchanger membrane	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
k59_560523_1	398767.Glov_3242	2.3e-13	70.9	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,42PHS@68525|delta/epsilon subdivisions,2X5NU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_560523_2	1122951.ATUE01000007_gene635	8.46e-12	67.0	COG3009@1|root,COG3009@2|Bacteria,1RII3@1224|Proteobacteria,1S7SN@1236|Gammaproteobacteria,3NT9P@468|Moraxellaceae	1236|Gammaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
k59_233093_1	305700.B447_01031	4.94e-110	335.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,2KU9R@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_103340_1	640081.Dsui_0704	9.65e-80	250.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,2KV3Q@206389|Rhodocyclales	206389|Rhodocyclales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN1	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_103340_2	1163617.SCD_n00556	5.64e-24	92.8	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria	28216|Betaproteobacteria	J	sigma 54 modulation protein ribosomal protein S30EA	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_886299_1	864073.HFRIS_008416	1.14e-30	112.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2VQ49@28216|Betaproteobacteria,473BX@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Polynucleotide kinase 3 phosphatase	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase,Hydrolase_like,PNK3P
k59_886299_2	1283300.ATXB01000001_gene679	4.58e-19	90.5	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1XENS@135618|Methylococcales	135618|Methylococcales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_919693_1	671143.DAMO_1116	2.35e-57	191.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_5420_1	1211579.PP4_28260	5.58e-80	252.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1YYF0@136845|Pseudomonas putida group	1236|Gammaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_38025_1	1123393.KB891330_gene906	2.85e-73	234.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,1KRB4@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_298823_1	398578.Daci_2550	1.23e-96	290.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2VI04@28216|Betaproteobacteria,4AASZ@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
k59_952134_1	1304874.JAFY01000007_gene2240	9.48e-20	94.4	COG2358@1|root,COG2358@2|Bacteria,3TANE@508458|Synergistetes	508458|Synergistetes	S	TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_70863_1	1177181.T9A_02150	1.19e-26	105.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1XM6I@135619|Oceanospirillales	135619|Oceanospirillales	L	DNA polymerase III chi subunit	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_919706_1	349521.HCH_05734	3.63e-119	360.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1XHCG@135619|Oceanospirillales	135619|Oceanospirillales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_560550_1	1288494.EBAPG3_17760	4.19e-80	259.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2VKKI@28216|Betaproteobacteria,372B1@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_266544_2	1408423.JHYA01000001_gene931	2.75e-11	65.1	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H2W4@909932|Negativicutes	909932|Negativicutes	L	SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	SNF2_N
k59_364222_1	1121861.KB899914_gene2088	1.02e-19	91.7	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_495389_1	748247.AZKH_p0054	1.63e-95	288.0	COG3381@1|root,COG3381@2|Bacteria,1R97V@1224|Proteobacteria,2VNS6@28216|Betaproteobacteria,2KVVK@206389|Rhodocyclales	206389|Rhodocyclales	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
k59_364223_1	1244869.H261_16009	1.72e-64	200.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2VA82@28211|Alphaproteobacteria,2JYFN@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_266550_1	1121405.dsmv_1392	3.33e-77	242.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,2MJ0P@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_632175_1	2340.JV46_05690	7.09e-142	410.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_110098_1	264198.Reut_C6071	2.17e-72	232.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VIE4@28216|Betaproteobacteria,1K2M0@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1_6,DUF772
k59_502187_1	6239.MTCE.11	1.24e-22	95.5	COG1005@1|root,KOG4770@2759|Eukaryota,39SC3@33154|Opisthokonta,3BGSE@33208|Metazoa,3DDRC@33213|Bilateria,40H4C@6231|Nematoda,1M0CU@119089|Chromadorea,415Y8@6236|Rhabditida	33208|Metazoa	C	NADH dehydrogenase	ND1	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010033,GO:0010257,GO:0014070,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030425,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032981,GO:0032991,GO:0033108,GO:0033194,GO:0034622,GO:0034641,GO:0036477,GO:0042221,GO:0042493,GO:0042773,GO:0042775,GO:0042995,GO:0043005,GO:0043025,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044463,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0050896,GO:0055086,GO:0055114,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0097447,GO:0097458,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0120025,GO:0120038,GO:1901135,GO:1901360,GO:1901564,GO:1901700,GO:1902494,GO:1990204	1.6.5.3	ko:K03878	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADHdh
k59_370699_1	1121127.JAFA01000090_gene3622	7.24e-95	284.0	COG2801@1|root,COG2801@2|Bacteria,1MY62@1224|Proteobacteria,2VJAF@28216|Betaproteobacteria,1K2XD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_502198_1	983917.RGE_25300	9.3e-82	259.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,1KKDF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	acetolactate synthase	xsc	-	2.2.1.6,2.3.3.15,4.1.1.8	ko:K01577,ko:K01652,ko:K03852	ko00290,ko00430,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00430,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01908,R03050,R04672,R04673,R05651,R08648	RC00027,RC00106,RC00620,RC01192,RC02744,RC02893,RC02903,RC02909	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_435971_1	1304883.KI912532_gene1579	4.49e-06	45.4	2ENZW@1|root,33GKQ@2|Bacteria,1NQCD@1224|Proteobacteria,2VXYX@28216|Betaproteobacteria,2KXJX@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_435971_2	1384056.N787_09095	1.9e-82	253.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1X38C@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_175421_1	1366050.N234_30165	5.08e-119	368.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1K6SR@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_502199_1	1304885.AUEY01000059_gene2397	8.27e-97	305.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MHQW@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_730643_2	404589.Anae109_1062	8.88e-36	129.0	COG5649@1|root,COG5649@2|Bacteria,1PCA0@1224|Proteobacteria,438XC@68525|delta/epsilon subdivisions,2X42P@28221|Deltaproteobacteria,2YY3P@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_730648_1	1123261.AXDW01000010_gene451	7.34e-92	287.0	COG1132@1|root,COG1132@2|Bacteria,1MXC2@1224|Proteobacteria,1RZQR@1236|Gammaproteobacteria,1XCEP@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
k59_990971_1	1095769.CAHF01000011_gene2648	4.7e-64	205.0	COG0657@1|root,COG0657@2|Bacteria,1MV3J@1224|Proteobacteria,2VNRV@28216|Betaproteobacteria	28216|Betaproteobacteria	I	esterase	-	-	3.5.1.9	ko:K01432	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3,COesterase
k59_272460_1	930166.CD58_24095	1.12e-50	177.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345	SBP_bac_3,SLT
k59_926583_1	1321778.HMPREF1982_00035	2.9e-51	181.0	COG2511@1|root,COG2511@2|Bacteria,1UPG0@1239|Firmicutes,25HFT@186801|Clostridia	186801|Clostridia	J	GatB/GatE catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GatB_N
k59_730652_1	1304883.KI912532_gene421	4.09e-48	158.0	COG3671@1|root,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria,2KWZK@206389|Rhodocyclales	206389|Rhodocyclales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_730652_2	1121035.AUCH01000008_gene1109	1.3e-26	101.0	COG4575@1|root,COG4575@2|Bacteria,1N6X7@1224|Proteobacteria,2WFR8@28216|Betaproteobacteria,2KX05@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
k59_730652_3	269482.Bcep1808_0746	3.65e-12	65.5	COG5393@1|root,COG5393@2|Bacteria,1N5Q0@1224|Proteobacteria,2VV9G@28216|Betaproteobacteria,1K7WT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
k59_632210_1	713586.KB900536_gene1194	3.01e-139	403.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_207762_1	1382306.JNIM01000001_gene2685	3.3e-35	134.0	COG2309@1|root,COG2309@2|Bacteria,2G5TH@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M29, aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k59_175441_1	288000.BBta_1460	5.93e-157	461.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_787505_2	483219.LILAB_12355	7.71e-30	112.0	28R6X@1|root,2ZDKX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_893530_2	1216976.AX27061_6059	4.42e-09	61.2	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,3T2ZB@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_436857_2	941824.TCEL_00782	1.36e-52	180.0	COG1653@1|root,COG1653@2|Bacteria,1UM42@1239|Firmicutes,25GA6@186801|Clostridia,36NBE@31979|Clostridiaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17311	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	SBP_bac_8
k59_731541_1	1265502.KB905938_gene2439	2.13e-98	297.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,4ABI9@80864|Comamonadaceae	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_731541_2	1538295.JY96_04810	2.07e-17	78.6	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,1KJJA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
k59_633064_2	1267534.KB906754_gene2902	3.7e-31	120.0	COG0628@1|root,COG0628@2|Bacteria,3Y6VE@57723|Acidobacteria,2JK9F@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_600707_1	338966.Ppro_3716	2.93e-111	326.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42R4P@68525|delta/epsilon subdivisions,2X5AT@28221|Deltaproteobacteria,43W1U@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_927505_1	420662.Mpe_A2523	2.38e-41	150.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,1KJY6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	molybdopterin	moeA2	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_761459_2	1216976.AX27061_3483	2.29e-23	101.0	COG0454@1|root,COG0503@1|root,COG1040@1|root,COG0456@2|Bacteria,COG0503@2|Bacteria,COG1040@2|Bacteria,1PDRS@1224|Proteobacteria,2W9KW@28216|Betaproteobacteria,3T8GR@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_305912_1	945713.IALB_2297	2.41e-81	247.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2395	Fer2_3,Fer4_7,Fer4_8
k59_305912_2	1191523.MROS_0456	3.84e-29	116.0	2E7RG@1|root,3326T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_111035_1	436308.Nmar_1686	5.28e-15	72.8	COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota	651137|Thaumarchaeota	F	aspartate carbamoyltransferase	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_111035_2	1229909.NSED_08975	1.27e-110	322.0	arCOG10598@1|root,arCOG10598@2157|Archaea	2157|Archaea	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
k59_402497_1	1288494.EBAPG3_24940	3.85e-75	238.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,372HP@32003|Nitrosomonadales	28216|Betaproteobacteria	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_402497_2	640081.Dsui_2909	2.02e-135	393.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VI7S@28216|Betaproteobacteria,2KXUT@206389|Rhodocyclales	206389|Rhodocyclales	E	Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_666385_1	1095769.CAHF01000013_gene3405	1.73e-54	186.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,473DE@75682|Oxalobacteraceae	28216|Betaproteobacteria	MU	TIGRFAM type I secretion outer membrane protein, TolC family	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_111041_1	987059.RBXJA2T_10626	2.43e-82	253.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,1KJEX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_787818_2	398767.Glov_2019	1.78e-49	169.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,43U3Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_893549_1	266265.Bxe_A2660	3.01e-191	544.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1K6RB@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Group II intron, maturase-specific domain	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,Intron_maturas2,RVT_1
k59_111042_2	195250.CM001776_gene3763	1.88e-67	210.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1GYC7@1129|Synechococcus	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
k59_568326_1	436308.Nmar_0380	1.44e-23	98.6	arCOG10517@1|root,arCOG10517@2157|Archaea,41T0I@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_176340_1	1306990.BARG01000047_gene5807	2.27e-71	229.0	COG1878@1|root,COG1878@2|Bacteria,2I8ZI@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_893556_1	118161.KB235922_gene4299	4.27e-29	115.0	COG3386@1|root,COG3386@2|Bacteria,1G05C@1117|Cyanobacteria,3VHKB@52604|Pleurocapsales	1117|Cyanobacteria	G	PFAM SMP-30 Gluconolaconase LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_402510_1	1120956.JHZK01000002_gene996	3.59e-62	199.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	dddQ	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2,DUF4437
k59_402510_2	1125973.JNLC01000011_gene593	1.28e-18	84.7	COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2TV6R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase	ligC	-	1.1.1.312	ko:K10219	ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220	M00533	R04278,R04279,R04418,R04419	RC00251,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_13364_1	1380394.JADL01000004_gene5935	7.49e-75	238.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,2JR5U@204441|Rhodospirillales	204441|Rhodospirillales	E	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_402511_1	1123487.KB892856_gene2546	1.25e-65	209.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,2KVBG@206389|Rhodocyclales	206389|Rhodocyclales	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_402511_2	266265.Bxe_A3981	1.85e-29	112.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,1JZTS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_666405_1	5111.M1WI29	5.6e-09	57.8	COG0299@1|root,KOG3076@2759|Eukaryota,38GB0@33154|Opisthokonta,3NZTK@4751|Fungi,3QRTU@4890|Ascomycota,212RJ@147550|Sordariomycetes,3TE87@5125|Hypocreales,3G1UU@34397|Clavicipitaceae	4751|Fungi	G	ACT domain	-	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
k59_731586_1	1236959.BAMT01000001_gene1287	7.16e-81	249.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KM5R@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_893564_1	305700.B447_05228	1.92e-88	266.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,2KUV5@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_699216_1	1254432.SCE1572_46360	6.62e-70	230.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,43CJE@68525|delta/epsilon subdivisions,2X7TT@28221|Deltaproteobacteria,2Z3N4@29|Myxococcales	28221|Deltaproteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66
k59_503170_1	330214.NIDE3560	5.57e-06	47.8	COG1894@1|root,COG1894@2|Bacteria,3J0WA@40117|Nitrospirae	40117|Nitrospirae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_503170_2	330214.NIDE3559	6.49e-57	179.0	COG0633@1|root,COG0633@2|Bacteria	2|Bacteria	C	Ferredoxin	fdx	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
k59_45675_1	204773.HEAR2645	5.8e-23	96.3	COG0810@1|root,COG0810@2|Bacteria,1MZQW@1224|Proteobacteria,2VU0N@28216|Betaproteobacteria,474MU@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
k59_45675_2	1121861.KB899918_gene3217	1.87e-29	112.0	COG1951@1|root,COG1951@2|Bacteria,1MW8J@1224|Proteobacteria,2U0X2@28211|Alphaproteobacteria,2JWAC@204441|Rhodospirillales	204441|Rhodospirillales	C	Fumarate hydratase (Fumerase)	-	-	-	-	-	-	-	-	-	-	-	-	Fumerase
k59_143757_1	1266925.JHVX01000009_gene75	4.63e-63	210.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,372WX@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_402524_1	909663.KI867150_gene686	5.98e-06	49.3	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria,2MQK4@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_402524_2	1121472.AQWN01000004_gene908	5.54e-22	93.2	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,260RP@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
k59_699230_1	945713.IALB_2375	1.06e-63	200.0	COG1428@1|root,COG1428@2|Bacteria	2|Bacteria	F	Deoxynucleoside kinase	dgk	-	2.7.1.113	ko:K15518	ko00230,map00230	-	R01967	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HPPK,dNK
k59_699230_2	436114.SYO3AOP1_1187	3.9e-07	51.6	COG0801@1|root,COG0801@2|Bacteria,2G4AJ@200783|Aquificae	200783|Aquificae	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_305960_1	221027.JO40_09975	5.54e-18	84.0	COG1088@1|root,COG1088@2|Bacteria,2J5ND@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_305960_2	1492922.GY26_05955	5.81e-26	101.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1J65A@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
k59_143765_1	243090.RB3877	1.56e-128	380.0	COG3119@1|root,COG3119@2|Bacteria,2IXNZ@203682|Planctomycetes	203682|Planctomycetes	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_600779_1	420662.Mpe_A3098	3.83e-22	94.7	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,1KM03@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	MlaA lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_339420_1	384676.PSEEN5270	3.16e-63	207.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_503204_1	1242864.D187_005861	4.81e-16	78.2	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YVB7@29|Myxococcales	28221|Deltaproteobacteria	J	Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_861404_1	713586.KB900536_gene1289	1.8e-44	162.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,1WYW3@135613|Chromatiales	135613|Chromatiales	O	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8,Trans_reg_C
k59_960164_1	743299.Acife_2330	1.14e-54	187.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,1SDJ1@1236|Gammaproteobacteria,2NDQ9@225057|Acidithiobacillales	225057|Acidithiobacillales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_600800_1	404589.Anae109_0972	1.75e-23	101.0	COG0003@1|root,COG0003@2|Bacteria,1NA7C@1224|Proteobacteria,42V2J@68525|delta/epsilon subdivisions,2WS25@28221|Deltaproteobacteria,2YUZS@29|Myxococcales	28221|Deltaproteobacteria	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
k59_13417_2	1535287.JP74_22965	9.29e-43	149.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,3N64K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_790258_1	1131266.ARWQ01000001_gene1216	4.27e-66	204.0	COG0723@1|root,arCOG01720@2157|Archaea,41SCE@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Rieske 2Fe-2S domain	-	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,TAT_signal
k59_790258_2	1229909.NSED_08480	2.66e-104	315.0	COG1290@1|root,arCOG01721@2157|Archaea,41SDA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Cytochrome b subunit of the bc complex	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_407830_1	243233.MCA0095	9.44e-80	262.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEV2@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_472921_1	1485544.JQKP01000002_gene1357	2.37e-59	204.0	COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,2WGMC@28216|Betaproteobacteria,44V6B@713636|Nitrosomonadales	28216|Betaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_867640_1	518766.Rmar_2276	5.14e-48	159.0	COG0800@1|root,COG0800@2|Bacteria,4NEFY@976|Bacteroidetes	976|Bacteroidetes	G	KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
k59_867640_2	1168034.FH5T_18300	1.22e-05	47.4	COG1028@1|root,COG1028@2|Bacteria,4NG8R@976|Bacteroidetes,2FMB9@200643|Bacteroidia	976|Bacteroidetes	IQ	Oxidoreductase, short chain dehydrogenase reductase family protein	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_51750_1	1000565.METUNv1_02487	2.59e-25	100.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2VJRD@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_51750_2	305900.GV64_08265	1.5e-56	186.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1XH3P@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_182502_1	243233.MCA2269	5.59e-73	228.0	COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,1RN7R@1236|Gammaproteobacteria,1XF7G@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_738146_1	987059.RBXJA2T_07588	9.75e-82	248.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VIKP@28216|Betaproteobacteria,1KPEI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_85801_1	765911.Thivi_4499	8.05e-64	219.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,1T2G2@1236|Gammaproteobacteria,1WWTU@135613|Chromatiales	135613|Chromatiales	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
k59_900044_1	497321.C664_09070	4.09e-84	249.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2VPZW@28216|Betaproteobacteria,2KW37@206389|Rhodocyclales	206389|Rhodocyclales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_312260_1	383372.Rcas_0002	6.95e-36	135.0	COG5621@1|root,COG5621@2|Bacteria,2G6EI@200795|Chloroflexi,374YJ@32061|Chloroflexia	32061|Chloroflexia	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
k59_312260_2	330214.NIDE0518	9.37e-29	109.0	COG2802@1|root,COG2802@2|Bacteria,3J13Q@40117|Nitrospirae	40117|Nitrospirae	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
k59_767477_1	1121937.AUHJ01000011_gene2859	1.51e-129	379.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,46529@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Glutamine synthetase, catalytic domain	spuB	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_607610_1	395493.BegalDRAFT_2182	6.8e-81	254.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,4601I@72273|Thiotrichales	72273|Thiotrichales	C	TIGRFAM cytochrome c oxidase accessory protein FixG	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_836947_1	580332.Slit_0470	1.67e-90	269.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2VQ49@28216|Betaproteobacteria,44VFT@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Polynucleotide kinase 3 phosphatase	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase,Hydrolase_like,PNK3P
k59_118075_1	498211.CJA_2809	3.78e-21	90.9	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1FH4V@10|Cellvibrio	1236|Gammaproteobacteria	S	P-loop ATPase protein family	rapZ	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_118075_2	265072.Mfla_0146	2.69e-21	88.6	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,2KMX4@206350|Nitrosomonadales	206350|Nitrosomonadales	G	PFAM PTS system fructose subfamily IIA component	-	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	EIIA-man
k59_998742_1	864051.BurJ1DRAFT_4690	3.37e-36	140.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_934653_1	1121004.ATVC01000055_gene616	9.29e-55	181.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,2KPDY@206351|Neisseriales	206351|Neisseriales	H	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_934653_2	443255.SCLAV_1689	7.51e-11	63.5	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_183160_1	1121920.AUAU01000006_gene254	1.39e-87	270.0	COG2403@1|root,COG2403@2|Bacteria,3Y6GM@57723|Acidobacteria	57723|Acidobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_706453_1	945713.IALB_2953	2.05e-95	286.0	COG0549@1|root,COG0549@2|Bacteria	2|Bacteria	E	Belongs to the carbamate kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3652,iE2348C_1286.E2348C_0454,iECABU_c1320.ECABU_c31550,iECED1_1282.ECED1_0540,iECED1_1282.ECED1_3334,iECIAI39_1322.ECIAI39_3289,iECNA114_1301.ECNA114_2915,iECOK1_1307.ECOK1_3260,iECS88_1305.ECS88_3153,iECSF_1327.ECSF_2670,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iHN637.CLJU_RS13830,iJN746.PP_0999,iUMN146_1321.UM146_02150,iUTI89_1310.UTI89_C3259,ic_1306.c3452	AA_kinase
k59_378272_1	404589.Anae109_0028	2.25e-75	234.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,4383U@68525|delta/epsilon subdivisions,2X3DT@28221|Deltaproteobacteria,2YVM7@29|Myxococcales	28221|Deltaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_575412_2	1125863.JAFN01000001_gene2546	9.04e-85	258.0	COG2069@1|root,COG2069@2|Bacteria,1QS8G@1224|Proteobacteria,437H2@68525|delta/epsilon subdivisions,2WKVX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
k59_346300_1	998674.ATTE01000001_gene1372	2.95e-55	178.0	COG3090@1|root,COG3090@2|Bacteria,1RBHY@1224|Proteobacteria,1S5RE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_738876_1	857087.Metme_3359	2.07e-123	383.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1XG1J@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_312279_1	436308.Nmar_1369	3.14e-26	97.1	arCOG08651@1|root,arCOG08651@2157|Archaea,41TB6@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_312279_2	436308.Nmar_1368	4.55e-55	179.0	COG0457@1|root,arCOG03038@2157|Archaea,41SMV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
k59_868357_1	1238450.VIBNISOn1_300033	3.5e-58	186.0	2DBRK@1|root,2ZAME@2|Bacteria,1P1YU@1224|Proteobacteria,1S8J7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_443618_1	864051.BurJ1DRAFT_4378	4.22e-78	243.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,1KK4B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_967296_1	436308.Nmar_0298	1.72e-23	90.9	arCOG03272@1|root,arCOG03272@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_967296_2	1229909.NSED_06755	1.2e-17	76.3	arCOG08688@1|root,arCOG08688@2157|Archaea,41T55@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_443623_1	945713.IALB_0844	2.36e-109	335.0	COG0046@1|root,COG0046@2|Bacteria	2|Bacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_443624_1	1123234.AUKI01000019_gene347	2.93e-47	165.0	COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,1HWVX@117743|Flavobacteriia	976|Bacteroidetes	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_276394_1	85643.Tmz1t_1263	2.58e-80	255.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,2KVZ5@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_276394_2	305700.B447_07162	9.38e-23	88.6	COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,2VUFA@28216|Betaproteobacteria,2KX0Q@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
k59_868372_1	1112217.PPL19_09166	0.000214	42.7	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,1SJY0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	COG1172 Ribose xylose arabinose galactoside ABC-type transport systems, permease components	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
k59_868372_2	1112217.PPL19_09161	5.46e-38	137.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,1RPBV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Periplasmic	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
k59_607651_1	225849.swp_0564	1.02e-34	127.0	COG2862@1|root,COG2862@2|Bacteria,1RFUX@1224|Proteobacteria,1S75J@1236|Gammaproteobacteria,2QBM8@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Uncharacterized protein family, UPF0114	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
k59_836996_1	1254432.SCE1572_29595	9.57e-21	94.4	COG0515@1|root,COG0642@1|root,COG0784@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X7MY@28221|Deltaproteobacteria,2YXD9@29|Myxococcales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HAMP,HATPase_c,HisKA,Pkinase,Response_reg
k59_575444_1	1232410.KI421413_gene761	2.16e-23	94.7	COG2716@1|root,COG2716@2|Bacteria,1Q2TM@1224|Proteobacteria,42W89@68525|delta/epsilon subdivisions,2WSEF@28221|Deltaproteobacteria,43V1Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT_6
k59_575444_2	338963.Pcar_2672	6.56e-49	167.0	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,43TNQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_640031_1	1219049.SP5_035_00060	4.59e-08	59.3	COG1414@1|root,COG1414@2|Bacteria,1RJF5@1224|Proteobacteria,2UC70@28211|Alphaproteobacteria,2KD0B@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_868381_1	795666.MW7_2236	2.57e-102	322.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,1K1J9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_443635_2	596152.DesU5LDRAFT_0337	0.000175	43.5	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,42KZU@68525|delta/epsilon subdivisions,2WJ6T@28221|Deltaproteobacteria,2M7RJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	drug resistance transporter, EmrB QacA subfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
k59_510191_2	292415.Tbd_0416	1.06e-40	136.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,1KRSE@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Ribosomal proteins 50S L24/mitochondrial 39S L24	-	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	ribosomal_L24
k59_607670_2	522306.CAP2UW1_3435	2.46e-20	85.1	COG3671@1|root,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria	28216|Betaproteobacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_575455_1	1443665.JACA01000007_gene103	2.35e-20	87.4	COG2318@1|root,COG2318@2|Bacteria,4NU20@976|Bacteroidetes,1IMA1@117743|Flavobacteriia,2YIVT@290174|Aquimarina	976|Bacteroidetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
k59_575455_2	945713.IALB_3102	8.16e-37	132.0	COG3358@1|root,COG3358@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
k59_510193_1	397945.Aave_0228	7.25e-10	59.7	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKQJ@28216|Betaproteobacteria,4AAKR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_510193_2	264198.Reut_B5764	1.37e-32	127.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNBG@28216|Betaproteobacteria,1K297@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
k59_738920_1	67593.Physo108936	6.66e-07	52.8	COG0084@1|root,KOG3020@2759|Eukaryota,3QAJ9@4776|Peronosporales	4776|Peronosporales	L	TatD related DNase	-	-	6.5.1.4	ko:K01974,ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	RTC,TatD_DNase
k59_738920_2	765912.Thimo_0634	2.99e-22	96.3	COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,1RRH7@1236|Gammaproteobacteria,1WX4G@135613|Chromatiales	135613|Chromatiales	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_607674_1	269799.Gmet_0033	4.03e-69	231.0	COG2766@1|root,COG2766@2|Bacteria,1NG7R@1224|Proteobacteria,42P8B@68525|delta/epsilon subdivisions,2WJIU@28221|Deltaproteobacteria,43S2Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PrkA serine protein kinase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_PrkA,PrkA
k59_706509_2	640081.Dsui_1326	7.19e-47	158.0	COG0517@1|root,COG0517@2|Bacteria,1RJTX@1224|Proteobacteria,2VTQI@28216|Betaproteobacteria,2KWPB@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_967337_1	395495.Lcho_0980	7.65e-95	306.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1KJE9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_215536_1	1232683.ADIMK_1210	1.38e-84	263.0	COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,1RYBB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_607680_1	279383.Q5DN94_9CAUD	1.32e-12	72.4	4QCW5@10239|Viruses,4QWI1@35237|dsDNA viruses  no RNA stage,4QQVP@28883|Caudovirales,4QKSV@10699|Siphoviridae	10699|Siphoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_118147_1	397288.C806_00978	3.65e-27	110.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,27K96@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_85886_1	1163617.SCD_n02673	9.47e-18	84.7	COG3167@1|root,COG3167@2|Bacteria,1N1KE@1224|Proteobacteria,2VV3H@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	carbon utilization	-	-	-	ko:K12280	-	-	-	-	ko00000,ko02044	-	-	-	T2SSM
k59_1021698_1	1049564.TevJSym_al00210	6.84e-87	284.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_443662_1	981384.AEYW01000001_gene1559	0.000116	44.3	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TTJF@28211|Alphaproteobacteria,4NBSF@97050|Ruegeria	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	coxM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_443662_2	1120956.JHZK01000009_gene1682	3.42e-75	231.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2TQSY@28211|Alphaproteobacteria,1JNPR@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	ABC-2 type transporter	yadH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_738936_1	765912.Thimo_2854	7.29e-30	111.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1WVYC@135613|Chromatiales	135613|Chromatiales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_738936_2	870187.Thini_3317	2.55e-51	164.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,460UB@72273|Thiotrichales	72273|Thiotrichales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_738936_4	998674.ATTE01000001_gene4284	1.12e-10	60.8	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,45ZZI@72273|Thiotrichales	72273|Thiotrichales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_934742_1	1122603.ATVI01000007_gene1801	1.43e-76	249.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales	135614|Xanthomonadales	S	transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_20471_1	314607.KB13_634	1.12e-38	138.0	2C5U9@1|root,30FF7@2|Bacteria,1N2U0@1224|Proteobacteria,2WIIE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_640065_1	945713.IALB_1866	5.22e-39	145.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria	2|Bacteria	H	ADP-dependent NAD(P)H-hydrate dehydratase activity	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_245208_1	522306.CAP2UW1_3500	7.52e-44	162.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,1KPMY@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_408492_1	1131553.JIBI01000002_gene1782	2.44e-66	226.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,372K8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_150853_1	1239962.C943_00727	1.09e-52	180.0	COG1477@1|root,COG1477@2|Bacteria,4NGEK@976|Bacteroidetes,47N34@768503|Cytophagia	976|Bacteroidetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_52477_2	1288494.EBAPG3_24400	8.06e-94	289.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,37277@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_312358_2	977880.RALTA_A2337	4.97e-60	193.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2VIU0@28216|Betaproteobacteria,1K06S@119060|Burkholderiaceae	28216|Betaproteobacteria	H	riboflavin synthase alpha	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_312358_3	748247.AZKH_1007	1.39e-19	87.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,2KUY4@206389|Rhodocyclales	206389|Rhodocyclales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_646344_2	1001585.MDS_3644	2.96e-05	47.4	28IAG@1|root,2Z8D2@2|Bacteria,1P5EH@1224|Proteobacteria,1RYCA@1236|Gammaproteobacteria,1YCYG@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
k59_250771_4	1089439.KB902249_gene1173	0.000169	43.9	COG2944@1|root,COG2944@2|Bacteria,1N05Y@1224|Proteobacteria,1SCCM@1236|Gammaproteobacteria,46186@72273|Thiotrichales	72273|Thiotrichales	K	Helix-turn-helix	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
k59_157119_2	644968.DFW101_0703	8.77e-17	82.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMH@68525|delta/epsilon subdivisions,2WSVT@28221|Deltaproteobacteria,2MHGC@213115|Desulfovibrionales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_793158_1	99598.Cal7507_2600	1.22e-60	197.0	COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria,1G3D1@1117|Cyanobacteria,1HKI6@1161|Nostocales	1117|Cyanobacteria	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
k59_479008_1	203119.Cthe_1794	1.08e-48	175.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,3WGA7@541000|Ruminococcaceae	186801|Clostridia	J	translation elongation	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_124443_1	945713.IALB_0288	5.37e-91	291.0	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	1.1.1.3,1.4.1.2,2.7.7.19,2.7.7.42,2.7.7.59,2.7.7.72,2.7.7.89	ko:K00003,ko:K00970,ko:K00974,ko:K00982,ko:K00990,ko:K06950,ko:K15371	ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,ko03013,ko03018,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020,map03013,map03018	M00017,M00018	R00243,R01773,R01775,R09382,R09383,R09384,R09386	RC00006,RC00078,RC00087,RC02799	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2,PolyA_pol,PolyA_pol_RNAbd
k59_874646_1	864051.BurJ1DRAFT_1077	1.71e-91	279.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,1KKCG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	AMP-binding enzyme	paaK_2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_58492_1	748247.AZKH_4168	4.87e-08	57.0	COG3735@1|root,COG3735@2|Bacteria,1RBFT@1224|Proteobacteria,2VTX0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_58492_2	1175306.GWL_26700	4.97e-87	266.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,47249@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_221679_1	1449350.OCH239_14415	4.9e-11	69.3	COG0747@1|root,COG0747@2|Bacteria,1MUP8@1224|Proteobacteria,2TQXX@28211|Alphaproteobacteria,4KKXN@93682|Roseivivax	28211|Alphaproteobacteria	E	ABC transporter	MA20_20695	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_384278_1	398525.KB900701_gene989	5.1e-79	246.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_713088_1	379066.GAU_2777	3.64e-101	319.0	COG0466@1|root,COG0466@2|Bacteria,1ZTCH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_352724_2	269799.Gmet_1864	1.6e-73	238.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WTUB@28221|Deltaproteobacteria,43T1I@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	General secretory system II, protein E domain protein	pulE-1	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_906265_1	204669.Acid345_4460	5.68e-21	90.5	COG0745@1|root,COG0745@2|Bacteria,3Y4IJ@57723|Acidobacteria,2JJIF@204432|Acidobacteriia	204432|Acidobacteriia	K	PFAM response regulator receiver	-	-	-	ko:K07662	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_221717_1	748247.AZKH_3902	5.12e-107	331.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,2KVA6@206389|Rhodocyclales	206389|Rhodocyclales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_318106_1	880071.Fleli_2435	8.93e-09	61.2	COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	srrB	-	-	ko:K20971	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022	-	-	-	CBS,GAF_2,HAMP,PilZ,Response_reg,SpoIIE,Y_Y_Y,dCache_1
k59_318106_2	1121918.ARWE01000001_gene2752	0.000669	44.3	COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
k59_157176_1	861299.J421_2878	5.09e-12	70.9	COG1295@1|root,COG1295@2|Bacteria,1ZTHX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_713130_1	987059.RBXJA2T_01740	1e-119	354.0	COG0775@1|root,COG0775@2|Bacteria,1MUMQ@1224|Proteobacteria,2VKRE@28216|Betaproteobacteria,1KJND@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations	amn	-	3.2.2.4	ko:K01241	ko00230,map00230	-	R00182	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	AMNp_N,PNP_UDP_1
k59_384328_1	1122603.ATVI01000008_gene2316	2.81e-19	89.4	COG3327@1|root,COG3327@2|Bacteria,1RABS@1224|Proteobacteria,1S2WE@1236|Gammaproteobacteria,1X6K8@135614|Xanthomonadales	135614|Xanthomonadales	K	PaaX-like protein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PaaX,PaaX_C
k59_414160_1	96561.Dole_0660	6.26e-71	228.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_941372_1	330214.NIDE0490	2.04e-85	258.0	COG0289@1|root,COG0289@2|Bacteria,3J0IJ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_26904_1	1266914.ATUK01000018_gene635	1.58e-70	214.0	28PZA@1|root,2ZCIS@2|Bacteria,1RCMD@1224|Proteobacteria,1SEW0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_614097_1	395495.Lcho_3893	3.71e-47	172.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_537293_1	323848.Nmul_A2742	7.74e-20	81.6	COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,373HW@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Belongs to the BolA IbaG family	yrbA	-	-	-	-	-	-	-	-	-	-	-	BolA
k59_537293_2	1288494.EBAPG3_9340	2.44e-65	206.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,3724C@32003|Nitrosomonadales	28216|Betaproteobacteria	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_874720_1	926569.ANT_12310	8.18e-31	114.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_843788_1	420662.Mpe_A3249	1.36e-66	215.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2VI2Z@28216|Betaproteobacteria,1KN33@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	SAF	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
k59_843788_2	305700.B447_10533	1.15e-34	127.0	COG3945@1|root,COG3945@2|Bacteria,1N12K@1224|Proteobacteria,2VUPY@28216|Betaproteobacteria,2KWW8@206389|Rhodocyclales	206389|Rhodocyclales	S	Hemerythrin HHE cation binding	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_479069_1	1298867.AUES01000046_gene4088	1.27e-69	225.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,3JXHZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_352799_1	936455.KI421499_gene7531	4.72e-98	300.0	COG0747@1|root,COG0747@2|Bacteria,1MWR7@1224|Proteobacteria,2TS51@28211|Alphaproteobacteria,3JT3B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_516871_1	62928.azo3051	1.03e-37	135.0	COG3945@1|root,COG3945@2|Bacteria,1N12K@1224|Proteobacteria,2VUPY@28216|Betaproteobacteria,2KWW8@206389|Rhodocyclales	206389|Rhodocyclales	S	Hemerythrin HHE cation binding	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_189261_1	205922.Pfl01_0775	1.24e-44	153.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1YQ02@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN746.PP_4715	TIM
k59_843799_2	1123393.KB891333_gene2538	2.82e-54	179.0	COG0664@1|root,COG0664@2|Bacteria,1RAF3@1224|Proteobacteria,2VQIC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
k59_974097_1	1054217.TALC_00194	1.41e-29	118.0	COG3958@1|root,arCOG01051@2157|Archaea,2Y86K@28890|Euryarchaeota,241IF@183967|Thermoplasmata	183967|Thermoplasmata	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_974097_2	68219.JNXI01000002_gene4074	7.2e-21	89.7	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_26937_1	1459636.NTE_03136	2.15e-18	89.7	arCOG08812@1|root,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_384367_1	1217718.ALOU01000038_gene3385	5.27e-08	53.5	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2VHRQ@28216|Betaproteobacteria,1K3N2@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Cytochrome C oxidase assembly protein ctag	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_384367_2	323848.Nmul_A0186	1.02e-13	66.6	2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria,2WBTJ@28216|Betaproteobacteria,373SB@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF2970)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2970
k59_384367_3	62928.azo3299	7.79e-27	105.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,2KVIW@206389|Rhodocyclales	206389|Rhodocyclales	C	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_582274_1	1459636.NTE_01634	2.33e-89	275.0	COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA primase	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
k59_793203_1	945713.IALB_0398	1.91e-20	89.0	COG1562@1|root,COG1562@2|Bacteria	2|Bacteria	I	ergosterol biosynthetic process	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99	ko:K00801,ko:K02291,ko:K10208	ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130	M00097	R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177	RC00362,RC00796,RC01101,RC02839,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_793203_2	1434325.AZQN01000001_gene283	3.18e-12	65.9	arCOG05416@1|root,2ZZTD@2|Bacteria,4NNMY@976|Bacteroidetes,47Q57@768503|Cytophagia	976|Bacteroidetes	S	lycopene cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_414184_1	85643.Tmz1t_0065	0.000126	48.9	2DBQ4@1|root,2ZABV@2|Bacteria,1R8WU@1224|Proteobacteria,2VP1M@28216|Betaproteobacteria,2KZK8@206389|Rhodocyclales	206389|Rhodocyclales	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
k59_874748_1	987059.RBXJA2T_09327	1.18e-123	375.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,1KJ39@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_189283_1	1049564.TevJSym_ac01400	2.03e-20	96.3	28N8G@1|root,2ZBCV@2|Bacteria,1NMB1@1224|Proteobacteria,1SMP0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_516894_1	63737.Npun_F1939	9.99e-21	90.5	COG0517@1|root,COG0517@2|Bacteria,1G08K@1117|Cyanobacteria,1HJEI@1161|Nostocales	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CP12
k59_713192_1	158500.BV97_03264	1.94e-59	191.0	COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,2TUCA@28211|Alphaproteobacteria,2K3ZV@204457|Sphingomonadales	204457|Sphingomonadales	S	Pyridoxamine 5'-phosphate	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
k59_516899_1	1463917.JODC01000013_gene1545	8.97e-26	111.0	COG0745@1|root,COG3903@1|root,COG0745@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,GerE,NB-ARC,Response_reg,TPR_12,Trans_reg_C
k59_414192_1	1348657.M622_05505	2.85e-71	239.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA topoisomerase III	-	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
k59_646473_1	228410.NE0348	2.3e-37	130.0	COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,2W9PG@28216|Betaproteobacteria,374C0@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	-	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
k59_646473_2	1304883.KI912532_gene2454	5.12e-21	89.7	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2VQIR@28216|Betaproteobacteria,2KW28@206389|Rhodocyclales	206389|Rhodocyclales	L	NADH pyrophosphatase-like rudimentary NUDIX domain	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
k59_318181_1	436308.Nmar_1091	2.42e-66	212.0	COG1378@1|root,arCOG02037@2157|Archaea,41T17@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
k59_414193_1	420324.KI912022_gene340	3.33e-178	521.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,1JT1D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_352840_1	1236959.BAMT01000004_gene898	5.69e-31	122.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,2KMD8@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
k59_843835_1	235985.BBPN01000010_gene4388	2.67e-41	139.0	COG0494@1|root,COG0494@2|Bacteria,2II0E@201174|Actinobacteria,2NMYB@228398|Streptacidiphilus	201174|Actinobacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_124574_1	1215114.BBIU01000028_gene3376	1.99e-09	59.7	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,1RQMR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KQ	transcriptional regulator	acoR	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS_8,PAS_9,Sigma54_activat
k59_124574_2	1232447.BAHW02000032_gene2405	6.49e-22	97.4	COG0115@1|root,COG0115@2|Bacteria,1V3JS@1239|Firmicutes,24JA5@186801|Clostridia	186801|Clostridia	EH	Aminotransferase class IV	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
k59_26960_1	177437.HRM2_10870	2.45e-20	91.3	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MIIU@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_26960_2	1121405.dsmv_1720	9.37e-30	112.0	COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,2MHT7@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_1005080_1	1288494.EBAPG3_27530	1.24e-61	208.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,371VT@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_537323_1	1232437.KL662006_gene4368	2.69e-57	183.0	COG4319@1|root,COG4319@2|Bacteria,1PA0J@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_384399_1	977880.RALTA_A2504	6.65e-84	260.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1K1YA@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid	livK2	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_479109_1	1000565.METUNv1_02301	1.54e-85	270.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,2KV1E@206389|Rhodocyclales	206389|Rhodocyclales	O	COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_745663_1	1229909.NSED_00620	1.68e-169	486.0	COG0459@1|root,arCOG01257@2157|Archaea,41T11@651137|Thaumarchaeota	651137|Thaumarchaeota	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k59_1025073_1	1282876.BAOK01000001_gene2365	2.84e-25	107.0	COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,2TZUW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
k59_384401_1	870187.Thini_4010	6.05e-85	265.0	COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,1RMV3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation	nifK	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF3364,Oxidored_nitro
k59_384401_2	1232683.ADIMK_3057	2.87e-41	147.0	COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,1RSFD@1236|Gammaproteobacteria,4645E@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Nitrogenase component 1 type Oxidoreductase	nifD	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
k59_26977_1	551789.ATVJ01000001_gene2630	3.16e-07	51.2	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria,43WGY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_26977_2	648757.Rvan_1583	8.02e-43	142.0	COG1605@1|root,COG1605@2|Bacteria,1PV10@1224|Proteobacteria,2V6I1@28211|Alphaproteobacteria,3N78S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Chorismate mutase, type II	-	-	4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R06602	RC01549,RC02148	ko00000,ko00001,ko01000	-	-	-	CM_2
k59_680474_1	522772.Dacet_0166	1.19e-50	171.0	COG0842@1|root,COG0842@2|Bacteria,2GEN1@200930|Deferribacteres	200930|Deferribacteres	V	Transport permease protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
k59_582323_1	316274.Haur_3564	1.54e-13	69.3	COG0345@1|root,COG0345@2|Bacteria,2G5QD@200795|Chloroflexi,375AU@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_844578_1	557598.LHK_00957	7.33e-32	129.0	COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,2KU48@206351|Neisseriales	206351|Neisseriales	J	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34	mnmC	-	2.1.1.61	ko:K15461	-	-	R00601,R08702	RC00003,RC00053,RC00060,RC01483	ko00000,ko01000,ko03016	-	-	-	DAO,Methyltransf_30
k59_385060_2	764299.STRIC_0111	2.58e-06	51.6	COG5283@1|root,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,4HEHJ@91061|Bacilli	91061|Bacilli	D	Phage-related minor tail protein	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_793490_1	159087.Daro_4059	1.58e-85	267.0	COG4402@1|root,COG4402@2|Bacteria,1MVMM@1224|Proteobacteria,2VZKJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
k59_423286_1	2002.JOEQ01000016_gene7347	1.26e-36	141.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,4EG08@85012|Streptosporangiales	201174|Actinobacteria	M	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,WD40
k59_259597_1	987059.RBXJA2T_14336	6.78e-129	372.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,1KJNM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_544050_1	1124780.ANNU01000013_gene3775	2.86e-09	66.2	COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,47JMR@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_259636_1	765911.Thivi_0061	1.5e-36	141.0	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_487811_1	67267.JNXT01000083_gene2865	5.89e-12	69.3	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria	201174|Actinobacteria	GL	phosphoglycerate mutase	-	-	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
k59_487811_2	1446473.JHWH01000015_gene3630	5.18e-06	48.9	COG1028@1|root,COG1028@2|Bacteria,1RBGC@1224|Proteobacteria,2U6FD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_487854_1	926560.KE387023_gene3415	5.51e-15	70.9	COG0454@1|root,COG0454@2|Bacteria,1WMP9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_487854_2	1391647.AVSV01000028_gene162	1.07e-13	72.8	COG0454@1|root,COG4977@1|root,COG0456@2|Bacteria,COG4977@2|Bacteria,1VIBT@1239|Firmicutes,24B6J@186801|Clostridia,36F23@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_259701_1	706587.Desti_1030	2.23e-12	71.6	COG1309@1|root,COG1309@2|Bacteria,1RGQQ@1224|Proteobacteria	1224|Proteobacteria	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_285044_1	159087.Daro_3515	1.17e-119	365.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,2KUYS@206389|Rhodocyclales	206389|Rhodocyclales	C	nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_797020_1	1133022.I6NPA3_9CAUD	2.87e-54	193.0	4QKSZ@10699|Siphoviridae	10699|Siphoviridae	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_797020_3	883081.HMPREF9698_01601	0.000766	41.6	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H9YP@91061|Bacilli,27FNS@186828|Carnobacteriaceae	91061|Bacilli	KL	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_487893_1	983917.RGE_10600	1.51e-72	229.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,1KKEZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	ugpC	-	3.6.3.20	ko:K05816,ko:K10111,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00198,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.3	-	-	ABC_tran,TOBE_2
k59_487901_1	204669.Acid345_2712	6.41e-94	293.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
k59_285063_1	305700.B447_07634	4.04e-63	197.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VR3P@28216|Betaproteobacteria,2KWCV@206389|Rhodocyclales	206389|Rhodocyclales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_487918_1	1104324.P186_0332	1.84e-25	105.0	COG2358@1|root,arCOG01801@2157|Archaea,2XS27@28889|Crenarchaeota	28889|Crenarchaeota	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_487918_2	120017.I2G5D3	1.3e-05	46.6	COG0082@1|root,KOG4492@2759|Eukaryota,38EIY@33154|Opisthokonta,3NUJB@4751|Fungi,3UZFH@5204|Basidiomycota,3MZJT@452284|Ustilaginomycotina	4751|Fungi	E	Chorismate synthase	ARO2	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042602,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_544217_1	945713.IALB_0283	2.16e-90	293.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
k59_782596_1	1419583.V466_22875	2.32e-76	230.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,1S3X0@1236|Gammaproteobacteria,1YSV9@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_782596_2	1121920.AUAU01000001_gene2168	1.87e-31	117.0	COG2519@1|root,COG2519@2|Bacteria,3Y5T2@57723|Acidobacteria	57723|Acidobacteria	J	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_259817_1	1232410.KI421428_gene1224	5.98e-91	297.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,43S5H@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	RNA polymerase I subunit A N-terminus	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_797053_2	330214.NIDE2519	9.94e-52	176.0	COG1690@1|root,COG1690@2|Bacteria,3J0X0@40117|Nitrospirae	40117|Nitrospirae	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_782630_1	497321.C664_14449	1.57e-78	263.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,2KUMU@206389|Rhodocyclales	206389|Rhodocyclales	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_259868_2	1487953.JMKF01000022_gene2509	2.02e-180	514.0	COG0161@1|root,COG0161@2|Bacteria,1G1QE@1117|Cyanobacteria,1H9SQ@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.18,2.6.1.62	ko:K00822,ko:K00833	ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100	M00123,M00573,M00577	R00907,R03231,R04187	RC00006,RC00008,RC00062,RC00160,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_488032_1	1485544.JQKP01000002_gene1509	5.38e-82	258.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,44V04@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Nitrogen metabolism transcriptional regulator, NtrC, Fis Family	ntrC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_782651_1	497321.C664_15698	8.59e-33	133.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVC7@206389|Rhodocyclales	206389|Rhodocyclales	T	PAC sensor-containing diguanylate cyclase phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,PAS,PAS_9
k59_259911_1	296591.Bpro_0114	1.04e-65	203.0	COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria,2VRG7@28216|Betaproteobacteria,4ADXZ@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM thioesterase superfamily protein	-	-	3.1.2.28	ko:K19222	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000	-	-	-	4HBT
k59_544339_1	395495.Lcho_3739	1.83e-12	72.8	COG0689@1|root,COG5276@1|root,COG0689@2|Bacteria,COG5276@2|Bacteria,1QVI5@1224|Proteobacteria	1224|Proteobacteria	N	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,He_PIG,LVIVD
k59_544343_1	391589.RGAI101_4088	2.32e-16	77.4	COG4665@1|root,COG4665@2|Bacteria,1RDYM@1224|Proteobacteria,2TVMY@28211|Alphaproteobacteria,2P2Z4@2433|Roseobacter	28211|Alphaproteobacteria	Q	COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_544343_2	909943.HIMB100_00017660	1.18e-10	64.3	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BPHI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	TIGRFAM TRAP transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_259947_1	1163617.SCD_n02724	4.92e-79	260.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VJK5@28216|Betaproteobacteria	28216|Betaproteobacteria	G	pyruvate phosphate dikinase	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_544347_1	1297569.MESS2_300063	2.21e-08	60.8	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria	1224|Proteobacteria	E	Sarcosine oxidase, beta subunit	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
k59_285152_1	1265505.ATUG01000003_gene689	1.24e-57	190.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MR6@68525|delta/epsilon subdivisions,2WNMA@28221|Deltaproteobacteria,2MPWF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_423732_1	706587.Desti_2842	6.4e-20	83.6	2EUYT@1|root,33NE0@2|Bacteria,1P79U@1224|Proteobacteria,432X2@68525|delta/epsilon subdivisions,2WXB8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_423732_2	1121405.dsmv_2046	7.84e-43	157.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2MHM6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_544420_1	649638.Trad_1832	1.99e-17	84.7	COG0667@1|root,COG0667@2|Bacteria,1WJPB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_488189_1	397945.Aave_2732	4.54e-71	239.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,4A9UV@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_423801_1	1123367.C666_08805	2.52e-46	158.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,2VJYI@28216|Betaproteobacteria,2KUNK@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S binding domain	napH	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4_5,Fer4_6
k59_423801_2	511062.GU3_11055	5.79e-28	107.0	COG0437@1|root,COG0437@2|Bacteria,1N9WY@1224|Proteobacteria,1RNHT@1236|Gammaproteobacteria,1Y5IK@135624|Aeromonadales	135624|Aeromonadales	C	4Fe-4S binding domain	-	-	-	ko:K02573	-	-	-	-	ko00000	-	-	-	Fer4_4,Fer4_7
k59_782831_1	1203605.HMPREF1531_01263	5.61e-10	64.3	COG2984@1|root,COG2984@2|Bacteria,2GKNV@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter substrate-binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_488241_1	768670.Calni_0521	6.39e-72	229.0	COG1055@1|root,COG1055@2|Bacteria	2|Bacteria	P	arsenite transmembrane transporter activity	arsB	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_260108_1	1000565.METUNv1_04051	1.2e-72	227.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales	206389|Rhodocyclales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
k59_782838_1	153948.NAL212_2508	1.57e-89	267.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2VQI2@28216|Betaproteobacteria,372TT@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_797141_1	388051.AUFE01000019_gene4397	6.03e-26	106.0	COG2223@1|root,COG2223@2|Bacteria,1QU4X@1224|Proteobacteria,2WH87@28216|Betaproteobacteria,1KIIC@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Acetyl-coenzyme A transporter 1	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
k59_488273_1	1125863.JAFN01000001_gene1023	9.21e-135	388.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_423882_1	224911.27356519	4.07e-128	379.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MXYQ@1224|Proteobacteria,2TSX4@28211|Alphaproteobacteria,3JT1E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_32
k59_488334_1	1031288.AXAA01000046_gene2137	1.74e-82	265.0	COG1164@1|root,COG1164@2|Bacteria,1TQ5W@1239|Firmicutes,25CE1@186801|Clostridia,36FKN@31979|Clostridiaceae	186801|Clostridia	E	Oligoendopeptidase, pepF M3 family	pepF	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_260203_1	1266914.ATUK01000010_gene1389	1.95e-28	114.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RPKP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cobalamin synthesis protein, P47K	yeiR	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0008270,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_544556_1	1192034.CAP_8220	1.66e-59	198.0	COG4714@1|root,COG4714@2|Bacteria,1N40I@1224|Proteobacteria,434T4@68525|delta/epsilon subdivisions,2WZ46@28221|Deltaproteobacteria,2Z1A5@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2167
k59_1030314_1	518766.Rmar_2101	3.83e-40	142.0	COG1830@1|root,COG1830@2|Bacteria,4NEUM@976|Bacteroidetes,1FIWN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	DeoC/LacD family aldolase	fbaB	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
k59_548908_1	582899.Hden_0690	2.57e-115	343.0	COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_801860_1	305700.B447_19354	2.37e-50	173.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,2KYD7@206389|Rhodocyclales	206389|Rhodocyclales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_289598_1	580332.Slit_0008	1.43e-43	146.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria,44VPM@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_289599_1	1123504.JQKD01000021_gene5734	2.18e-44	151.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria,4AA2I@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protocatechuate 4,5-dioxygenase	-	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
k59_289599_2	688245.CtCNB1_2740	1.74e-91	276.0	COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2VIRJ@28216|Betaproteobacteria,4AAC0@80864|Comamonadaceae	28216|Betaproteobacteria	S	Oxidoreductase	ligC	-	1.1.1.312	ko:K10219	ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220	M00533	R04278,R04279,R04418,R04419	RC00251,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_zinc_N,GFO_IDH_MocA
k59_289627_2	1121451.DESAM_22834	3.46e-05	47.0	28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,42Z58@68525|delta/epsilon subdivisions,2WTW4@28221|Deltaproteobacteria,2M8HG@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_801908_1	1304284.L21TH_0375	4.87e-35	133.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24AD9@186801|Clostridia,36H90@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	DUF35_N,Thiolase_C,Thiolase_N,ketoacyl-synt
k59_289658_1	452637.Oter_0831	2.13e-57	199.0	COG2366@1|root,COG2366@2|Bacteria	2|Bacteria	D	antibiotic biosynthetic process	acyII	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_801930_1	1163617.SCD_n02080	2.8e-52	169.0	COG3671@1|root,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria	28216|Betaproteobacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1033912_1	1236902.ANAS01000033_gene927	3.14e-12	72.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4EQSM@85012|Streptosporangiales	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_801934_1	257310.BB1998	2.89e-90	281.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,3T5BW@506|Alcaligenaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_801964_1	269482.Bcep1808_6383	2.13e-05	47.8	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2VV9X@28216|Betaproteobacteria,1K8N9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_801964_2	1163409.UUA_05897	7.78e-63	196.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1X5XQ@135614|Xanthomonadales	135614|Xanthomonadales	S	EVE domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_801964_3	582744.Msip34_0158	4.2e-37	127.0	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,2VUY2@28216|Betaproteobacteria,2KP3R@206350|Nitrosomonadales	206350|Nitrosomonadales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
k59_801964_4	1288494.EBAPG3_10920	6.74e-16	72.4	2EG8X@1|root,33A0Q@2|Bacteria,1NMVN@1224|Proteobacteria,2VY0V@28216|Betaproteobacteria,373M2@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_289728_1	1049564.TevJSym_ac02050	7.31e-49	171.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1J4QZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_289736_1	1121878.AUGL01000006_gene743	4.48e-24	101.0	2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,1S7TX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
k59_289736_2	998674.ATTE01000001_gene409	3.78e-09	58.2	COG2197@1|root,COG2197@2|Bacteria,1R2TM@1224|Proteobacteria,1S8D3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_802024_1	497964.CfE428DRAFT_2050	8.51e-61	207.0	COG0025@1|root,COG0025@2|Bacteria,46TEQ@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_549100_1	1499967.BAYZ01000080_gene949	1.71e-85	266.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081	SHMT
k59_497009_1	640081.Dsui_2199	4.63e-47	152.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,2KX2Q@206389|Rhodocyclales	206389|Rhodocyclales	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_756485_1	76114.ebA5086	3.05e-16	76.3	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,2KU7X@206389|Rhodocyclales	206389|Rhodocyclales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_756485_2	1163617.SCD_n01892	1.32e-30	108.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0434 family	ycaR	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
k59_756485_3	1121035.AUCH01000015_gene2611	4.65e-26	105.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,2KU8U@206389|Rhodocyclales	206389|Rhodocyclales	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_823481_1	56780.SYN_01967	1.44e-50	164.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,42RDZ@68525|delta/epsilon subdivisions,2WQ4Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K06879,ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_823481_2	522306.CAP2UW1_3518	6.58e-40	142.0	COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,2VH6D@28216|Betaproteobacteria,1KQJE@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
k59_104996_1	1121479.AUBS01000001_gene3509	3.93e-108	323.0	COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2TS8K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	branched-chain amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_497018_1	1005048.CFU_3925	6.23e-09	56.2	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2VR8K@28216|Betaproteobacteria,47444@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_497018_2	1000565.METUNv1_00089	6.29e-61	193.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,2KUR3@206389|Rhodocyclales	206389|Rhodocyclales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_660286_1	1349767.GJA_5394	3.56e-85	278.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria	28216|Betaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_660286_2	580332.Slit_0281	1.56e-108	333.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VIMC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	dctB	-	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
k59_333426_1	1304885.AUEY01000080_gene1033	3.83e-82	258.0	COG2801@1|root,COG2801@2|Bacteria,1PFYJ@1224|Proteobacteria,439VW@68525|delta/epsilon subdivisions,2X5A0@28221|Deltaproteobacteria,2MP3D@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_39666_1	398720.MED217_03885	1.84e-70	226.0	COG2256@1|root,COG2256@2|Bacteria,4NEV8@976|Bacteroidetes,1HXHG@117743|Flavobacteriia,2XIA4@283735|Leeuwenhoekiella	976|Bacteroidetes	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_855565_1	1125863.JAFN01000001_gene1344	1.06e-52	176.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_855565_2	883.DvMF_0542	7.42e-22	89.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MCSM@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	TIGRFAM preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_594722_1	1502852.FG94_03224	1.03e-31	120.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,472UD@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_431102_2	1415166.NONO_c59010	7.27e-28	111.0	COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria,4FW3Q@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_39678_1	903818.KI912268_gene967	2.13e-34	125.0	COG0558@1|root,COG0558@2|Bacteria,3Y520@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_39678_2	292459.STH2266	1.36e-16	79.3	COG3267@1|root,COG3267@2|Bacteria,1TRGM@1239|Firmicutes,24BFG@186801|Clostridia	186801|Clostridia	U	SMART AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_170345_1	554065.XP_005843167.1	8.73e-09	62.0	COG1404@1|root,KOG1153@2759|Eukaryota	2759|Eukaryota	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_431104_1	1121887.AUDK01000025_gene1172	3.86e-36	139.0	COG1132@1|root,COG1132@2|Bacteria,4NE2D@976|Bacteroidetes,1HWWR@117743|Flavobacteriia,2NSNT@237|Flavobacterium	976|Bacteroidetes	V	Antibiotic ABC transporter ATP-binding protein	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_594724_1	886882.PPSC2_c2033	1.15e-76	250.0	COG0531@1|root,COG0531@2|Bacteria,1TQE1@1239|Firmicutes,4HAZH@91061|Bacilli,26RJ7@186822|Paenibacillaceae	91061|Bacilli	E	amino acid	ydaO1	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_986062_1	1267005.KB911258_gene123	7.44e-62	193.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2U5NM@28211|Alphaproteobacteria,3N8QC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_105026_1	1267533.KB906747_gene13	1.11e-47	169.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iSDY_1059.SDY_2473	Proton_antipo_M
k59_300412_1	977880.RALTA_A0859	2.84e-73	225.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2VIA5@28216|Betaproteobacteria,1K1P4@119060|Burkholderiaceae	28216|Betaproteobacteria	K	transcriptional regulatory protein	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_333455_1	525897.Dbac_1842	1.41e-86	263.0	COG1840@1|root,COG1840@2|Bacteria,1N9WT@1224|Proteobacteria	1224|Proteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_660322_1	491952.Mar181_1006	3.04e-34	128.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1XS5V@135619|Oceanospirillales	135619|Oceanospirillales	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_660322_2	1286631.X805_33040	2.58e-43	152.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B	ligB	-	1.13.11.57	ko:K04099	ko00627,ko01120,map00627,map01120	-	R03550,R04280,R09565	RC00233,RC00535,RC02567,RC02694	ko00000,ko00001,ko01000	-	-	-	LigA,LigB
k59_921435_1	1232410.KI421412_gene326	8.64e-17	77.8	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMJ8@28221|Deltaproteobacteria,43S86@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Multi-copper polyphenol oxidoreductase laccase	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_921435_2	1122994.AUFR01000028_gene49	5.22e-20	90.5	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4DN88@85009|Propionibacteriales	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_137765_1	1265505.ATUG01000001_gene4572	2.18e-10	61.2	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI4B@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_137765_2	96561.Dole_1956	3e-85	259.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2MHV5@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	ParA
k59_365878_1	1121935.AQXX01000109_gene480	2.33e-73	246.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_202855_2	944547.ABLL_1049	6.08e-16	79.7	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,42NUG@68525|delta/epsilon subdivisions,2YMYA@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_497067_1	1297617.JPJD01000082_gene1040	1.32e-59	191.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,268B5@186813|unclassified Clostridiales	186801|Clostridia	E	ATPases associated with a variety of cellular activities	livF1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_497067_2	401526.TcarDRAFT_0847	2.88e-18	80.5	COG1280@1|root,COG1280@2|Bacteria,1V4SU@1239|Firmicutes,4H4KY@909932|Negativicutes	909932|Negativicutes	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_7214_1	344747.PM8797T_10439	1.34e-68	217.0	COG2227@1|root,COG2227@2|Bacteria,2J4VC@203682|Planctomycetes	203682|Planctomycetes	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_333479_1	1100721.ALKO01000018_gene1169	7.18e-34	122.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VT4G@28216|Betaproteobacteria,4AERD@80864|Comamonadaceae	28216|Betaproteobacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_333479_2	266265.Bxe_C0034	8.96e-48	165.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2VNH5@28216|Betaproteobacteria,1K1YF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	VWA domain containing CoxE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	VWA_CoxE
k59_106044_2	344747.PM8797T_10439	2.18e-44	151.0	COG2227@1|root,COG2227@2|Bacteria,2J4VC@203682|Planctomycetes	203682|Planctomycetes	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_203812_1	935840.JAEQ01000003_gene109	4.92e-21	95.5	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,43JD6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_595759_1	330214.NIDE1421	1.44e-130	384.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3J0A1@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_563298_1	1163408.UU9_12123	2.79e-109	339.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1X4RY@135614|Xanthomonadales	135614|Xanthomonadales	NU	secretion system protein	xcsD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_235109_1	323848.Nmul_A0210	2.35e-101	308.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,37240@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_203815_1	1168059.KB899087_gene3025	2.61e-18	85.5	COG2242@1|root,COG2242@2|Bacteria,1R0I9@1224|Proteobacteria,2TZR6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_203815_2	1463857.JOFZ01000005_gene3348	2.27e-85	262.0	COG0413@1|root,COG0413@2|Bacteria,2IC16@201174|Actinobacteria	201174|Actinobacteria	H	Ketopantoate hydroxymethyltransferase	-	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_203815_3	1231391.AMZF01000094_gene104	1.14e-107	316.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	hpcH	-	2.7.7.38,4.1.2.20,4.1.2.52	ko:K00979,ko:K01630,ko:K02510	ko00053,ko00350,ko00540,ko01100,ko01120,map00053,map00350,map00540,map01100,map01120	M00063	R01645,R01647,R02754,R03277,R03351,R11396	RC00152,RC00307,RC00435,RC00572,RC00574,RC00910,RC03057	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HpcH_HpaI
k59_661323_1	330214.NIDE0947	3e-31	126.0	COG3829@1|root,COG4252@1|root,COG3829@2|Bacteria,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	-	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	CHASE2,HTH_8,Sigma54_activat
k59_498102_1	760568.Desku_1501	6.73e-20	87.4	COG2048@1|root,COG2048@2|Bacteria,1U4JW@1239|Firmicutes,24C8P@186801|Clostridia,263PA@186807|Peptococcaceae	186801|Clostridia	C	PFAM Cysteine-rich region, CCG	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_498102_2	477974.Daud_1252	1.09e-18	82.0	COG1150@1|root,COG1150@2|Bacteria,1V98Z@1239|Firmicutes,24JWG@186801|Clostridia,265DT@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_9
k59_824563_1	518766.Rmar_1647	1.25e-70	232.0	COG1757@1|root,COG1757@2|Bacteria,4NHP9@976|Bacteroidetes,1FIXG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_528026_1	553178.CAPGI0001_1512	3.64e-06	51.2	COG2356@1|root,COG2356@2|Bacteria,4NEGS@976|Bacteroidetes,1HWZV@117743|Flavobacteriia,1ETFT@1016|Capnocytophaga	976|Bacteroidetes	L	hmm pf04231	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1,LTD,fn3
k59_528026_6	1472912.A0A023NGQ5_9CAUD	1.81e-15	78.2	4QGY8@10239|Viruses,4QV0S@35237|dsDNA viruses  no RNA stage,4QTKH@28883|Caudovirales	28883|Caudovirales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_528026_10	1111728.ATYS01000001_gene2410	0.000243	45.1	COG1409@1|root,COG1409@2|Bacteria,1R4AZ@1224|Proteobacteria,1S5VS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
k59_563316_1	290397.Adeh_2316	2.52e-91	276.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YWJD@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_301345_1	469382.Hbor_09260	9.31e-43	151.0	COG0500@1|root,arCOG01783@2157|Archaea,2Y3CK@28890|Euryarchaeota,23ZK2@183963|Halobacteria	183963|Halobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_595784_1	765912.Thimo_0822	2.95e-44	164.0	COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,1S5D2@1236|Gammaproteobacteria,1WYVS@135613|Chromatiales	135613|Chromatiales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_171358_1	338966.Ppro_3056	6.12e-50	167.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,42NRX@68525|delta/epsilon subdivisions,2WK1K@28221|Deltaproteobacteria,43SU7@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0388	His_biosynth
k59_498119_1	1122132.AQYH01000002_gene1283	4.26e-16	78.2	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,4BAGU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_498119_2	1056820.KB900681_gene2859	7.7e-56	185.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_366880_1	1283300.ATXB01000001_gene1494	4.14e-55	183.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,1SZZW@1236|Gammaproteobacteria,1XFTU@135618|Methylococcales	135618|Methylococcales	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
k59_824582_1	1122194.AUHU01000008_gene3416	2.05e-121	353.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,464YS@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760	Coprogen_oxidas
k59_757337_1	1167006.UWK_00109	3.81e-35	137.0	COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0456@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2MK5E@213118|Desulfobacterales	28221|Deltaproteobacteria	BKQ	Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
k59_563335_1	1357423.S5MCV4_9CAUD	4.17e-30	121.0	4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses  no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae	10662|Myoviridae	S	Phage tail sheath protein	-	GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027	-	-	-	-	-	-	-	-	-	-	-
k59_563335_2	1357423.S5MV44_9CAUD	1.02e-62	209.0	4QHDM@10239|Viruses,4QYV6@35237|dsDNA viruses  no RNA stage,4QRD0@28883|Caudovirales,4QI2W@10662|Myoviridae	10662|Myoviridae	S	Terminase-like family	-	GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016032,GO:0016043,GO:0016787,GO:0016788,GO:0019058,GO:0019068,GO:0019069,GO:0019072,GO:0019075,GO:0022607,GO:0032991,GO:0034641,GO:0043170,GO:0043493,GO:0044085,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0046483,GO:0046797,GO:0051704,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0098009,GO:1901360,GO:1902494,GO:1904949	-	-	-	-	-	-	-	-	-	-	-
k59_40701_1	1125863.JAFN01000001_gene2482	3.59e-73	234.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_40701_2	1125863.JAFN01000001_gene2481	2.86e-51	165.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,42RRU@68525|delta/epsilon subdivisions,2WNBY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	TIGRFAM Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
k59_888874_1	330214.NIDE4161	5.16e-30	109.0	COG2210@1|root,COG2210@2|Bacteria	2|Bacteria	P	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_888874_2	330214.NIDE4162	5.8e-63	197.0	COG0177@1|root,COG0177@2|Bacteria,3J0K6@40117|Nitrospirae	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2,4.2.99.18	ko:K01142,ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_824612_1	365044.Pnap_2183	1.03e-100	321.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_831642_1	429009.Adeg_1257	1.17e-46	159.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
k59_831642_2	1121472.AQWN01000003_gene1446	3.79e-06	47.8	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,26072@186807|Peptococcaceae	186801|Clostridia	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_763010_1	1502770.JQMG01000001_gene211	3.15e-68	216.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,2KKFY@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_763010_2	1005048.CFU_0754	4.97e-06	47.4	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,472DJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type II/IV secretion system protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_531589_1	1379858.N508_01556	1.52e-14	74.7	COG0568@1|root,COG0568@2|Bacteria,2GET2@200930|Deferribacteres	200930|Deferribacteres	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_531589_2	330214.NIDE0442	1.49e-47	164.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_15221_1	1335760.ASTG01000016_gene119	7.69e-68	224.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2K6JI@204457|Sphingomonadales	204457|Sphingomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_8,Trans_reg_C
k59_404027_1	1265313.HRUBRA_00373	2.82e-70	236.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4V8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_15226_1	1454004.AW11_00631	3.78e-106	311.0	COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2WEAK@28216|Betaproteobacteria,1KR98@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	qseB	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_307637_1	394.NGR_c23550	1.29e-10	60.1	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,2U9BA@28211|Alphaproteobacteria,4BDR3@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
k59_307637_2	296591.Bpro_2056	1.55e-39	142.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05384,ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT_2
k59_1019287_1	330214.NIDE4207	7.99e-30	118.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
k59_863173_1	96561.Dole_3058	3.84e-73	237.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2MI4U@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_341242_1	644282.Deba_0424	3.74e-95	288.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2WJYY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM sulfate adenylyltransferase	sat	-	2.7.1.25,2.7.7.4	ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
k59_733564_1	384676.PSEEN0057	4.71e-52	178.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.10.3.10,1.9.3.1	ko:K02274,ko:K02298	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	iJN746.PP_0104	COX1
k59_733564_2	1265502.KB905941_gene2886	6.95e-13	68.6	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,4ABGS@80864|Comamonadaceae	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
k59_341246_2	977880.RALTA_A2600	1.09e-50	174.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,1K1FI@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_602573_1	864051.BurJ1DRAFT_3342	1.98e-78	248.0	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,2VPWB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2
k59_602573_2	504346.B5WZX5_BPPAJ	1.1e-08	58.5	4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses  no RNA stage,4QPCB@28883|Caudovirales,4QKM5@10699|Siphoviridae	10699|Siphoviridae	S	sequence-specific DNA binding	-	GO:0001047,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010944,GO:0016032,GO:0019012,GO:0019042,GO:0019044,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0043900,GO:0043902,GO:0043903,GO:0044212,GO:0044403,GO:0044419,GO:0045892,GO:0045934,GO:0046782,GO:0048518,GO:0048519,GO:0048523,GO:0048524,GO:0050434,GO:0050789,GO:0050792,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051704,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	-	-	-	-	-	-	-	-	-	-
k59_404041_1	693444.D782_3789	3.17e-33	120.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,283D5@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	K	Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_15247_1	945713.IALB_2071	7.84e-78	248.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
k59_373395_1	1197906.CAJQ02000027_gene1423	3.05e-53	176.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2TRGZ@28211|Alphaproteobacteria,3JQX4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	MA20_39720	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_635012_1	265072.Mfla_2443	4.07e-73	234.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,2KKUY@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_733582_1	760192.Halhy_0046	2.31e-20	93.6	COG0683@1|root,COG0683@2|Bacteria,4PP0X@976|Bacteroidetes,1IXJD@117747|Sphingobacteriia	976|Bacteroidetes	E	leucine binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_993725_2	570952.ATVH01000015_gene1282	4.38e-08	55.5	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,2JQBS@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_145649_1	686578.AFFX01000001_gene1514	1.71e-29	121.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	ybbP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_15266_1	670307.HYPDE_23738	1.3e-64	212.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,3N75D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_701194_1	283942.IL0968	7.97e-83	269.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,2QFJG@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_81671_2	1265505.ATUG01000002_gene2736	2.93e-29	115.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2MIPA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_930515_2	640081.Dsui_1318	1.68e-75	234.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,2KVU7@206389|Rhodocyclales	206389|Rhodocyclales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_241662_1	1538295.JY96_20250	4.67e-22	91.7	COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,2VU50@28216|Betaproteobacteria,1KKQ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	cytochrome C	cytC2	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_241662_2	420662.Mpe_A3534	3.26e-28	106.0	COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,2VSD1@28216|Betaproteobacteria,1KMHA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	MerR, DNA binding	cueR	-	-	ko:K19591,ko:K19592	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	MerR,MerR-DNA-bind
k59_763880_1	1239962.C943_03316	6.33e-78	275.0	COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,4NG54@976|Bacteroidetes,47MT2@768503|Cytophagia	976|Bacteroidetes	D	tail tape measure protein, TP901 family	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_211482_1	1348657.M622_04085	1.1e-16	75.9	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2VHGQ@28216|Betaproteobacteria,2KVJD@206389|Rhodocyclales	206389|Rhodocyclales	EH	anthranilate	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_211482_2	388051.AUFE01000032_gene3481	1.27e-57	189.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,1K17M@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_532092_1	1268622.AVS7_00586	1.67e-27	111.0	COG0668@1|root,COG0668@2|Bacteria,1MXH4@1224|Proteobacteria,2VM0E@28216|Betaproteobacteria,4AJT7@80864|Comamonadaceae	28216|Betaproteobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_532092_2	935848.JAEN01000007_gene2971	2.12e-28	112.0	COG0600@1|root,COG0600@2|Bacteria,1N0FV@1224|Proteobacteria,2U1I5@28211|Alphaproteobacteria,2PZ6K@265|Paracoccus	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_404904_1	338969.Rfer_0458	2.99e-55	195.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9,SBP_bac_3
k59_241670_1	234267.Acid_0709	3.5e-60	199.0	COG4656@1|root,COG4656@2|Bacteria	2|Bacteria	C	electron transfer activity	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_17,RnfC_N,SLBB
k59_439677_1	404589.Anae109_2922	1.5e-53	184.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,42YBQ@68525|delta/epsilon subdivisions,2WTKK@28221|Deltaproteobacteria,2Z06Q@29|Myxococcales	28221|Deltaproteobacteria	Q	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_832789_1	102129.Lepto7375DRAFT_1004	1.94e-66	214.0	COG3039@1|root,COG3039@2|Bacteria,1GCCT@1117|Cyanobacteria	1117|Cyanobacteria	L	COG3039 Transposase and inactivated derivatives, IS5 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_241682_1	1232410.KI421426_gene1459	3.31e-75	239.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42PGM@68525|delta/epsilon subdivisions,2X5J8@28221|Deltaproteobacteria,43SW4@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_532097_1	395493.BegalDRAFT_0681	1.39e-63	199.0	COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
k59_532097_2	1049564.TevJSym_af00690	4.1e-34	130.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,1RNTD@1236|Gammaproteobacteria,1J9TP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short_C2
k59_506057_2	76114.ebA6393	8.66e-76	230.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2VR4K@28216|Betaproteobacteria,2KWCA@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
k59_832803_1	994573.T472_0217410	3.37e-23	102.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,36DR1@31979|Clostridiaceae	186801|Clostridia	I	acyl-CoA dehydrogenase	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_439698_1	638303.Thal_0674	3.8e-65	211.0	COG0548@1|root,COG0548@2|Bacteria,2G3SD@200783|Aquificae	200783|Aquificae	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_179209_1	1120983.KB894577_gene3578	1.82e-84	260.0	COG0673@1|root,COG0673@2|Bacteria,1PGFP@1224|Proteobacteria,2V8DN@28211|Alphaproteobacteria,1JQA3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_16341_1	1265313.HRUBRA_00311	1.27e-66	217.0	COG2610@1|root,COG2610@2|Bacteria,1N2VU@1224|Proteobacteria,1RNCQ@1236|Gammaproteobacteria,1J7KX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EG	COG2610 H gluconate symporter and related permeases	-	-	-	-	-	-	-	-	-	-	-	-	GntP_permease
k59_963125_1	420662.Mpe_A0168	1.08e-98	312.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,1KJAA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_374424_1	887898.HMPREF0551_1643	2.4e-61	211.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,1K105@119060|Burkholderiaceae	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_439707_1	1380355.JNIJ01000012_gene1052	3.66e-73	228.0	COG1226@1|root,2Z9WE@2|Bacteria,1QV7C@1224|Proteobacteria,2TU7Y@28211|Alphaproteobacteria,3JUI4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
k59_404939_2	744980.TRICHSKD4_1725	1.11e-22	89.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_404939_3	7994.ENSAMXP00000011172	9.49e-05	47.0	COG0457@1|root,KOG0118@1|root,KOG0118@2759|Eukaryota,KOG0548@2759|Eukaryota,39SZH@33154|Opisthokonta,3BF8D@33208|Metazoa,3CX0N@33213|Bilateria,48CMA@7711|Chordata,495ZT@7742|Vertebrata,49RZ0@7898|Actinopterygii	33208|Metazoa	O	Tetratricopeptide repeat domain 31	TTC31	-	-	-	-	-	-	-	-	-	-	-	RRM_1,TPR_16,TPR_2,TPR_8
k59_702286_2	456442.Mboo_2359	7.42e-07	51.6	COG2191@1|root,arCOG00762@2157|Archaea,2Y3HQ@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM formylmethanofuran dehydrogenase, subunit E region	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
k59_571379_1	1286631.X805_31950	1.59e-99	298.0	COG1744@1|root,COG1744@2|Bacteria,1NGHH@1224|Proteobacteria,2VNN9@28216|Betaproteobacteria,1KJRT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
k59_81733_1	1209984.BN978_00713	5.02e-57	192.0	COG2368@1|root,COG2368@2|Bacteria,2GKIQ@201174|Actinobacteria,23B2W@1762|Mycobacteriaceae	201174|Actinobacteria	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	hpaB	-	1.14.13.166,1.14.13.29,1.14.14.15,1.14.14.8,1.14.14.9	ko:K00483,ko:K16901,ko:K21184,ko:K21726	ko00350,ko00380,ko00627,ko01059,ko01120,ko01130,ko01220,map00350,map00380,map00627,map01059,map01120,map01130,map01220	M00827,M00828	R02698,R03023,R03299,R09517,R10731	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
k59_114018_1	522306.CAP2UW1_1535	9.97e-138	399.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,1KQEM@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_114018_2	360094.PXO_02706	7.96e-21	89.7	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1X3CE@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_669492_1	391615.ABSJ01000022_gene292	1.4e-48	162.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1J5SD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_48540_1	1415779.JOMH01000001_gene1011	1.03e-106	324.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,1RNUB@1236|Gammaproteobacteria,1X5AX@135614|Xanthomonadales	135614|Xanthomonadales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_603656_1	870187.Thini_2100	8.16e-114	343.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,461JQ@72273|Thiotrichales	72273|Thiotrichales	F	Belongs to the 5'-nucleotidase family	-	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_241721_1	1169143.KB911038_gene6150	3.29e-16	76.3	COG3836@1|root,COG3836@2|Bacteria,1RCR7@1224|Proteobacteria,2WF9B@28216|Betaproteobacteria,1KCUA@119060|Burkholderiaceae	28216|Betaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
k59_241721_2	1205680.CAKO01000037_gene1184	6.1e-47	159.0	COG0491@1|root,COG0491@2|Bacteria,1N22F@1224|Proteobacteria,2U2V5@28211|Alphaproteobacteria,2JVNG@204441|Rhodospirillales	204441|Rhodospirillales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_832847_1	748280.NH8B_3721	1.9e-19	83.6	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2WG03@28216|Betaproteobacteria,2KS22@206351|Neisseriales	206351|Neisseriales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_342346_1	1163617.SCD_n02026	2.24e-195	559.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2VJ0R@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	hyfG	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
k59_669505_1	1288494.EBAPG3_5570	3.27e-27	110.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,371S3@32003|Nitrosomonadales	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_669505_2	762376.AXYL_04773	1.66e-39	142.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,3T2RR@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_16376_1	987059.RBXJA2T_11191	5.21e-124	370.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,1KJ18@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_16376_2	76114.ebB95	5.1e-51	162.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,2KWCQ@206389|Rhodocyclales	206389|Rhodocyclales	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
k59_439742_1	95619.PM1_0206680	6.97e-53	189.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_380050_2	443143.GM18_2041	1.76e-63	202.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,43VQC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Iron/manganese superoxide dismutases, C-terminal domain	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_609576_1	945713.IALB_1453	7.53e-44	148.0	COG0241@1|root,COG0241@2|Bacteria	2|Bacteria	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83,5.3.1.28	ko:K03271,ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05645,R05647,R09768,R09769,R09771	RC00017,RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like,NTP_transferase,PNK3P
k59_609576_2	945713.IALB_1452	3.77e-72	231.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1000592_1	1348657.M622_03000	7.49e-57	183.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,2KW8D@206389|Rhodocyclales	206389|Rhodocyclales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_1000592_2	1007103.AFHW01000081_gene1541	2.24e-07	51.6	COG0251@1|root,COG0251@2|Bacteria,1V5RB@1239|Firmicutes,4HHZF@91061|Bacilli,26XWG@186822|Paenibacillaceae	91061|Bacilli	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_475144_1	243233.MCA3061	0.00011	50.1	COG1587@1|root,COG2959@1|root,COG1587@2|Bacteria,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RV2A@1236|Gammaproteobacteria,1XE6W@135618|Methylococcales	135618|Methylococcales	H	HemX, putative uroporphyrinogen-III C-methyltransferase	-	-	2.1.1.107,4.2.1.75	ko:K02496,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HemX
k59_54192_1	666685.R2APBS1_1126	1.73e-27	109.0	2EIBB@1|root,33C2R@2|Bacteria,1R3EG@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_22338_1	439235.Dalk_2461	9.42e-56	189.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,43BF7@68525|delta/epsilon subdivisions,2X6TK@28221|Deltaproteobacteria,2MIQS@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_838977_2	1265502.KB905939_gene2370	2.67e-15	75.5	COG0784@1|root,COG0784@2|Bacteria,1QVYQ@1224|Proteobacteria,2WGV7@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_380061_1	266265.Bxe_C0821	4.02e-133	386.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria,1K2WR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_969327_1	864051.BurJ1DRAFT_3404	1.49e-48	175.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1KKDW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_314010_1	1288494.EBAPG3_5230	6.63e-53	176.0	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,2VSAZ@28216|Betaproteobacteria,372Z1@32003|Nitrosomonadales	28216|Betaproteobacteria	S	SURF1-like protein	surf1	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_22339_1	1267535.KB906767_gene2802	1.57e-113	344.0	COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria,2JHT1@204432|Acidobacteriia	204432|Acidobacteriia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_120038_1	288000.BBta_p0180	5.15e-43	150.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria,3JT28@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	small subunit	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_120038_2	1255043.TVNIR_2057	1.95e-48	169.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1WWKP@135613|Chromatiales	135613|Chromatiales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_534911_1	1191523.MROS_0402	8.46e-107	323.0	COG2978@1|root,COG2978@2|Bacteria	2|Bacteria	H	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity	ydaH	-	-	ko:K12942	-	-	-	-	ko00000	-	-	-	ABG_transport
k59_1000604_1	1163617.SCD_n01531	8.66e-21	90.1	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria	28216|Betaproteobacteria	I	catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-acp	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817	2.3.1.179	ko:K00646,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1000604_2	1454004.AW11_01221	2.62e-128	377.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2VHD4@28216|Betaproteobacteria,1KPZ8@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1000604_3	522306.CAP2UW1_2471	6.97e-59	188.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2VQ24@28216|Betaproteobacteria,1KPYM@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_675633_1	426355.Mrad2831_5856	8.3e-88	281.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,1JTKB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_120043_1	351348.Maqu_3125	1.42e-96	297.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,46ADA@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Cytochrome D1 heme domain	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_577431_1	439497.RR11_36	2.17e-80	252.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2TR5F@28211|Alphaproteobacteria,4NAW7@97050|Ruegeria	28211|Alphaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_277371_1	1380394.JADL01000004_gene5718	1.26e-98	297.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TT8C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_121128_2	1123508.JH636443_gene4589	5.12e-19	86.3	COG0846@1|root,COG0846@2|Bacteria,2IZ7P@203682|Planctomycetes	203682|Planctomycetes	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_185859_1	330214.NIDE0375	1.09e-43	148.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	DUF4041,GGDEF,HATPase_c,HisKA,Response_reg,T5orf172,dCache_1
k59_218399_1	1445613.JALM01000030_gene5389	9.14e-40	144.0	COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4DYBE@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_446525_1	1248916.ANFY01000003_gene687	4.92e-35	129.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2U3PD@28211|Alphaproteobacteria,2KCQW@204457|Sphingomonadales	204457|Sphingomonadales	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k59_446525_2	794903.OPIT5_22740	1.93e-35	135.0	COG0383@1|root,COG0383@2|Bacteria,46Y9K@74201|Verrucomicrobia,3K96C@414999|Opitutae	414999|Opitutae	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
k59_709593_1	1163617.SCD_n02923	5.3e-33	132.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria	28216|Betaproteobacteria	NT	chemotaxis	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_578601_2	1424334.W822_19575	1.01e-133	387.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2VIM3@28216|Betaproteobacteria,3T1DS@506|Alcaligenaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.46,4.2.1.83	ko:K10220,ko:K14333	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R00821,R04478	RC00390,RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_446528_1	335543.Sfum_3540	3.19e-56	184.0	2EBDE@1|root,32RKA@2|Bacteria,1N31E@1224|Proteobacteria,42UV4@68525|delta/epsilon subdivisions,2WQ3Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_643012_1	1121004.ATVC01000023_gene291	5.5e-22	98.6	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,2KPXP@206351|Neisseriales	206351|Neisseriales	H	HemY protein N-terminus	hemY	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N
k59_902953_1	756272.Plabr_3540	5.54e-62	213.0	COG0060@1|root,COG0060@2|Bacteria,2IWX2@203682|Planctomycetes	203682|Planctomycetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_970487_1	768671.ThimaDRAFT_2431	4.28e-21	92.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales	135613|Chromatiales	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_970487_2	998674.ATTE01000001_gene1671	5.57e-33	122.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,460CZ@72273|Thiotrichales	72273|Thiotrichales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_23459_1	948106.AWZT01000002_gene6242	5.87e-122	372.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,1K41J@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_411095_1	398578.Daci_0196	4.49e-35	129.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2VJQ2@28216|Betaproteobacteria,4A9SP@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_1001636_1	945713.IALB_0827	2.05e-70	235.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
k59_153817_1	1232683.ADIMK_2851	1.33e-27	110.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,464AW@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_381124_1	1089553.Tph_c06970	2.36e-58	198.0	COG1012@1|root,COG1012@2|Bacteria,1UHQT@1239|Firmicutes,25E5E@186801|Clostridia	186801|Clostridia	C	acetaldehyde dehydrogenase (acetylating)	-	-	1.2.1.10	ko:K00132	ko00620,ko00650,ko01100,ko01120,map00620,map00650,map01100,map01120	-	R00228,R01172	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_185893_1	1123267.JONN01000001_gene1570	8.37e-113	334.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K0Q2@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_55240_1	296591.Bpro_2805	1.84e-74	247.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,4AAQA@80864|Comamonadaceae	28216|Betaproteobacteria	C	formate dehydrogenase, alpha subunit	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_55240_2	426114.THI_0004	2.85e-47	166.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,1KK63@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	fdwB	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_742003_1	497321.C664_18834	3.88e-76	248.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VHZ2@28216|Betaproteobacteria,2KV7V@206389|Rhodocyclales	206389|Rhodocyclales	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_315010_1	292564.Cyagr_3432	1.57e-20	87.8	COG2172@1|root,COG2172@2|Bacteria,1GMR9@1117|Cyanobacteria,22TS9@167375|Cyanobium	1117|Cyanobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
k59_315010_2	1000565.METUNv1_01460	2.19e-33	119.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
k59_185895_1	338966.Ppro_1509	1.2e-13	66.6	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42WTD@68525|delta/epsilon subdivisions,2WSRU@28221|Deltaproteobacteria,43VEC@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	atpZ	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
k59_578640_1	247490.KSU1_B0323	1.08e-114	350.0	COG1523@1|root,COG1523@2|Bacteria,2IX65@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_411111_1	1187851.A33M_1175	9.6e-68	214.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,3FDAQ@34008|Rhodovulum	28211|Alphaproteobacteria	J	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_676820_1	323848.Nmul_A0176	5.15e-63	213.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,372D7@32003|Nitrosomonadales	28216|Betaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_55247_1	1229909.NSED_06260	7.53e-102	309.0	COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_88998_1	161156.JQKW01000007_gene699	1.05e-149	442.0	COG0504@1|root,COG0504@2|Bacteria,2GHMU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_643045_1	1123377.AUIV01000009_gene2580	4.94e-67	219.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1X5E6@135614|Xanthomonadales	135614|Xanthomonadales	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_610707_1	1286631.X805_16720	2.56e-53	176.0	COG1024@1|root,COG1024@2|Bacteria,1Q67Q@1224|Proteobacteria,2VJC1@28216|Betaproteobacteria,1KITU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_610707_2	1366050.N234_35510	2.34e-05	47.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VS7J@28216|Betaproteobacteria,1KGWP@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	1.14.13.239,1.14.15.7	ko:K00499,ko:K22443	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
k59_643046_1	945713.IALB_1274	8.06e-63	213.0	COG0514@1|root,COG0514@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase (RecQ)	recQ2	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
k59_513334_1	1107311.Q767_11610	1.24e-76	235.0	COG1215@1|root,COG1215@2|Bacteria,4NF0S@976|Bacteroidetes,1HYRX@117743|Flavobacteriia,2NST0@237|Flavobacterium	976|Bacteroidetes	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_218456_1	338963.Pcar_0145	1e-101	319.0	COG0306@1|root,COG0306@2|Bacteria,1QAR3@1224|Proteobacteria,42P0C@68525|delta/epsilon subdivisions,2WJWM@28221|Deltaproteobacteria,43SK8@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Phosphate transporter family	-	-	-	-	-	-	-	-	-	-	-	-	PHO4
k59_902980_1	1288494.EBAPG3_7410	4.05e-100	310.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,371WJ@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_535498_1	1215092.PA6_033_00170	2.63e-84	267.0	COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,1RMIU@1236|Gammaproteobacteria,1YE0V@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF839)	uxpB	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_218457_1	1283300.ATXB01000001_gene1274	7.17e-28	115.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_185913_1	519989.ECTPHS_01324	3.68e-17	80.5	COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,1X0WV@135613|Chromatiales	135613|Chromatiales	S	Divergent polysaccharide deacetylase	-	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
k59_185913_2	1123392.AQWL01000001_gene1588	1.87e-41	141.0	COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,2VS5Q@28216|Betaproteobacteria,1KSPI@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
k59_381153_1	640081.Dsui_1455	3.82e-70	233.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	-	-	-	-	-	-	-	-	-	GAF,T2SSE,T2SSE_N
k59_840195_1	999611.KI421504_gene2014	2.35e-69	223.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_1001677_1	1380394.JADL01000002_gene1315	1.83e-29	109.0	COG1546@1|root,COG1546@2|Bacteria,1RHXH@1224|Proteobacteria,2UACN@28211|Alphaproteobacteria,2JWT0@204441|Rhodospirillales	204441|Rhodospirillales	S	Competence-damaged protein	-	-	-	-	-	-	-	-	-	-	-	-	CinA
k59_1001677_2	1044.EH31_04985	3.44e-05	50.4	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TUPN@28211|Alphaproteobacteria,2KD37@204457|Sphingomonadales	204457|Sphingomonadales	C	FMN-dependent dehydrogenase	-	-	1.13.12.4	ko:K00467	ko00620,map00620	-	R00319	RC01312	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_153853_1	414684.RC1_1514	2.41e-49	167.0	COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2UB0B@28211|Alphaproteobacteria,2JVQE@204441|Rhodospirillales	204441|Rhodospirillales	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_937912_1	96561.Dole_1929	1.74e-16	78.6	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WN1U@28221|Deltaproteobacteria,2MICR@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_937912_2	1121921.KB898710_gene506	1.14e-36	132.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,2PMNU@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	P	ABC transporter	pstB	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_643076_2	926569.ANT_11650	3.22e-27	111.0	COG1239@1|root,COG1239@2|Bacteria,2G832@200795|Chloroflexi	200795|Chloroflexi	H	SMART AAA ATPase	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Mg_chelatase
k59_277957_1	1485544.JQKP01000013_gene1840	1.47e-104	324.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,2VI9X@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1001698_1	1123070.KB899254_gene1264	2.06e-42	150.0	COG1469@1|root,COG1469@2|Bacteria,46SIB@74201|Verrucomicrobia,2IU2Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Type I GTP cyclohydrolase folE2	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_218492_1	883168.HMPREF9318_02087	0.000408	47.8	COG1108@1|root,COG1108@2|Bacteria,1TPZB@1239|Firmicutes,4HBD7@91061|Bacilli	91061|Bacilli	P	ABC-type Mn2 Zn2 transport systems, permease components	mtsC	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944	-	ko:K11705,ko:K19972,ko:K19976	ko02010,map02010	M00318,M00791,M00792	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.14,3.A.1.15.15,3.A.1.15.2,3.A.1.15.6	-	-	ABC-3
k59_446618_1	234267.Acid_7336	9.66e-47	167.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria	57723|Acidobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_871440_1	76114.ebA1439	2.69e-103	310.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,2KVWG@206389|Rhodocyclales	206389|Rhodocyclales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_770308_1	96561.Dole_0002	4.9e-60	200.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2MI3F@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM FAD linked oxidase domain protein	larD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3245	FAD-oxidase_C,FAD_binding_4
k59_193305_1	1120972.AUMH01000009_gene539	1.13e-33	132.0	COG0297@1|root,COG1543@1|root,COG0297@2|Bacteria,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,4ITP1@91061|Bacilli,27ATI@186823|Alicyclobacillaceae	91061|Bacilli	G	Domain of unknown function (DUF1957)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1
k59_356877_2	1121935.AQXX01000142_gene2326	9.38e-64	214.0	28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria,1RSAN@1236|Gammaproteobacteria,1XNEQ@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_618844_2	1125863.JAFN01000001_gene3326	4.29e-48	168.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2WJEA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_226385_1	266264.Rmet_1974	2.74e-77	237.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,1K3P4@119060|Burkholderiaceae	28216|Betaproteobacteria	P	phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_750691_1	1125863.JAFN01000001_gene3549	8.22e-45	164.0	COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,42UPY@68525|delta/epsilon subdivisions,2WQZZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
k59_63231_1	883078.HMPREF9695_01352	8.88e-53	171.0	COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2U7V5@28211|Alphaproteobacteria,3JZAP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_255119_1	497964.CfE428DRAFT_1729	8.5e-55	178.0	COG0122@1|root,COG0122@2|Bacteria,46V2J@74201|Verrucomicrobia	74201|Verrucomicrobia	L	endonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
k59_322560_2	1047013.AQSP01000139_gene2377	6.56e-44	149.0	COG1057@1|root,COG1057@2|Bacteria,2NPJU@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.6.1.55	ko:K00969,ko:K03574	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	iAF987.Gmet_3200	CTP_transf_like,HD
k59_539797_1	522306.CAP2UW1_2015	9.09e-36	132.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2VHD1@28216|Betaproteobacteria,1KQJA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Alanine dehydrogenase/PNT, N-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_539797_2	76114.ebA5140	4.74e-171	496.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VKMW@28216|Betaproteobacteria,2KV2G@206389|Rhodocyclales	206389|Rhodocyclales	I	Poly-beta-hydroxybutyrate	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PhaC_N
k59_483220_1	1170562.Cal6303_5390	1.68e-33	122.0	COG0087@1|root,COG0087@2|Bacteria,1FZY5@1117|Cyanobacteria,1HJ2K@1161|Nostocales	1117|Cyanobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_255123_1	1070319.CAGGBEG34_770001	4.09e-34	134.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria,1K0XA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_522002_2	1123392.AQWL01000008_gene1202	9.43e-60	187.0	COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,2VT6I@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the Fur family	-	-	-	ko:K09826	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_454496_1	1121949.AQXT01000002_gene1083	4.72e-11	61.6	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,43WBF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ragA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_454496_2	1249627.D779_1262	7.05e-103	322.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,1WX21@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_226399_1	1415756.JQMY01000001_gene798	2.27e-95	299.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,2PF8C@252301|Oceanicola	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_879424_1	1504672.669784585	9.49e-51	173.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VZNH@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_946346_1	402777.KB235903_gene819	6.53e-33	123.0	COG1335@1|root,COG1335@2|Bacteria,1G10P@1117|Cyanobacteria,1H8R3@1150|Oscillatoriales	1117|Cyanobacteria	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_97516_1	880072.Desac_0517	5.47e-35	138.0	COG0784@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MQVW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg,dCache_1
k59_194095_1	1049564.TevJSym_ab00650	4.28e-46	167.0	COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	serine threonine protein kinase	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA,VWA_2
k59_618867_1	330214.NIDE0342	1.36e-79	261.0	COG1305@1|root,COG1305@2|Bacteria,3J150@40117|Nitrospirae	40117|Nitrospirae	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,Transglut_core
k59_1027536_1	234267.Acid_6808	2.46e-17	82.4	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,DUF3105,HTH_Tnp_IS630
k59_718086_1	545264.KB898751_gene2604	1.8e-16	83.6	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1WW2V@135613|Chromatiales	135613|Chromatiales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_685463_1	748247.AZKH_3848	5.79e-71	221.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,2KU9T@206389|Rhodocyclales	206389|Rhodocyclales	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_750737_1	1131266.ARWQ01000002_gene668	1.17e-29	111.0	arCOG03119@1|root,arCOG03119@2157|Archaea,41SMJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_389057_1	436114.SYO3AOP1_0213	1.1e-75	243.0	COG1217@1|root,COG1217@2|Bacteria,2G4QC@200783|Aquificae	200783|Aquificae	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_777720_1	880072.Desac_1990	2.04e-41	152.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,42NEP@68525|delta/epsilon subdivisions,2WPFQ@28221|Deltaproteobacteria,2MR1M@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
k59_979180_1	999541.bgla_1g03170	1.85e-59	186.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,1K77S@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_979180_2	1123487.KB892835_gene3654	1.32e-42	141.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,2KX1F@206389|Rhodocyclales	206389|Rhodocyclales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_226427_1	945713.IALB_1384	1.25e-79	253.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_357775_1	926569.ANT_26040	2.94e-25	102.0	COG5433@1|root,COG5433@2|Bacteria,2G91G@200795|Chloroflexi	200795|Chloroflexi	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_assoc
k59_1027540_1	1254432.SCE1572_43245	1.77e-92	281.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,42ZA3@68525|delta/epsilon subdivisions,2WUE3@28221|Deltaproteobacteria,2Z36C@29|Myxococcales	28221|Deltaproteobacteria	F	Metal binding domain of Ada	-	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18
k59_483252_2	101510.RHA1_ro00696	1.75e-16	84.3	COG0515@1|root,COG0515@2|Bacteria,2H5ZS@201174|Actinobacteria,4FZN3@85025|Nocardiaceae	201174|Actinobacteria	KLT	protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, penicillin binding and protein amino acid phosphorylation	-	-	2.7.11.1	ko:K08282,ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_31817_1	1121935.AQXX01000093_gene3417	3.16e-111	328.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XHJM@135619|Oceanospirillales	135619|Oceanospirillales	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	bkdA2	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_685473_1	864051.BurJ1DRAFT_1735	1.66e-28	114.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,2W055@28216|Betaproteobacteria,1KNG4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_522060_1	1415756.JQMY01000001_gene716	1.09e-46	162.0	COG3180@1|root,COG3180@2|Bacteria,1MUFS@1224|Proteobacteria,2U4QD@28211|Alphaproteobacteria,2PESI@252301|Oceanicola	28211|Alphaproteobacteria	S	Transition state regulatory protein AbrB	-	-	-	ko:K07120	-	-	-	-	ko00000	-	-	-	AbrB
k59_226440_1	398525.KB900701_gene6702	5.93e-140	417.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_522062_1	1000565.METUNv1_01868	7.02e-171	494.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,2KUNY@206389|Rhodocyclales	206389|Rhodocyclales	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_357793_1	330214.NIDE1429	3.85e-100	300.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_483261_1	748247.AZKH_p0169	7.54e-126	362.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	mtbC	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
k59_910978_1	869210.Marky_0350	1.52e-31	118.0	COG2032@1|root,COG2032@2|Bacteria,1WMZH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005575,GO:0005576,GO:0005615,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
k59_31846_1	1131814.JAFO01000001_gene3577	7.22e-64	209.0	COG0346@1|root,COG0346@2|Bacteria,1P5FR@1224|Proteobacteria,2TVCC@28211|Alphaproteobacteria,3F16R@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_35815	-	1.13.11.25	ko:K16049	ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220	-	R04597	RC01610	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_685501_1	219305.MCAG_03065	3.09e-22	98.2	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4DA9G@85008|Micromonosporales	201174|Actinobacteria	I	Phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_618922_1	402626.Rpic_0483	2.27e-21	92.8	2CDFS@1|root,32RXQ@2|Bacteria,1RIZ3@1224|Proteobacteria,2WFT8@28216|Betaproteobacteria,1K3W9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2946)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2944
k59_162001_1	1121904.ARBP01000045_gene1844	7.06e-18	84.7	COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,4NDXS@976|Bacteroidetes,47NPP@768503|Cytophagia	976|Bacteroidetes	HP	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,STN,TonB_dep_Rec
k59_322641_1	265072.Mfla_0292	2.97e-39	133.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,2KMYN@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_322641_2	1288494.EBAPG3_29940	4.91e-68	208.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,373A5@32003|Nitrosomonadales	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_587390_1	113395.AXAI01000009_gene2555	1.53e-11	69.7	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_194157_1	748247.AZKH_3639	2.71e-160	458.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,2KV6W@206389|Rhodocyclales	206389|Rhodocyclales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_777760_1	580332.Slit_1713	3.8e-23	97.1	2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,2W0AA@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_777760_2	2340.JV46_07780	1.23e-50	162.0	COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria,1RXXW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	reductase beta subunit	aprB	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
k59_718137_1	102232.GLO73106DRAFT_00033450	1.36e-92	280.0	COG2089@1|root,COG2089@2|Bacteria,1G78N@1117|Cyanobacteria	1117|Cyanobacteria	M	synthase	spsE	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
k59_194161_1	1266914.ATUK01000010_gene1134	3.84e-24	98.6	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,1WZIV@135613|Chromatiales	135613|Chromatiales	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_97606_1	864051.BurJ1DRAFT_2287	3.93e-26	105.0	2CEMN@1|root,3165X@2|Bacteria,1QE5W@1224|Proteobacteria,2WAJN@28216|Betaproteobacteria,1KP8H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	ko:K16258	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001	-	-	-	-
k59_979231_1	366394.Smed_6258	7.73e-33	127.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BC2J@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase and inactivated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
k59_226480_1	1229909.NSED_04950	1.93e-119	352.0	COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
k59_255194_1	221359.RS9916_33192	2.07e-41	147.0	COG0523@1|root,COG0523@2|Bacteria,1G0Q9@1117|Cyanobacteria,1GYDT@1129|Synechococcus	1117|Cyanobacteria	S	G3E family	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_618938_1	1198232.CYCME_0198	1.07e-57	182.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,1S2DE@1236|Gammaproteobacteria,46123@72273|Thiotrichales	72273|Thiotrichales	S	UPF0114 protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
k59_522107_1	391625.PPSIR1_33429	7.83e-18	87.8	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,42Y0Z@68525|delta/epsilon subdivisions,2WT7J@28221|Deltaproteobacteria,2YWBV@29|Myxococcales	28221|Deltaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_879505_1	243365.CV_3395	1.01e-81	256.0	COG0031@1|root,COG0517@1|root,COG0031@2|Bacteria,COG0517@2|Bacteria,1MUBE@1224|Proteobacteria,2VPRG@28216|Betaproteobacteria,2KSUP@206351|Neisseriales	206351|Neisseriales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_685523_1	1202962.KB907154_gene809	2.42e-80	261.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alkaline phosphatase	pafA	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_357844_1	1056512.D515_03807	2.47e-25	103.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1XT2V@135623|Vibrionales	135623|Vibrionales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0009987,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_587407_1	34007.IT40_09060	3.2e-15	76.6	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2PUQB@265|Paracoccus	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_587407_2	483219.LILAB_14730	2.62e-08	53.9	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,42ZZH@68525|delta/epsilon subdivisions,2WVGR@28221|Deltaproteobacteria,2YUQ1@29|Myxococcales	28221|Deltaproteobacteria	O	maleylacetoacetate isomerase	maiA	-	5.2.1.2,5.2.1.4	ko:K01800,ko:K01801	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181,R03868	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_C_3,GST_N,GST_N_3
k59_685527_2	1123368.AUIS01000029_gene1288	4.46e-97	296.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415,ko:K18148	ko01501,map01501	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	RtcB
k59_718159_1	1038922.PflQ2_3034	3.91e-43	154.0	COG1252@1|root,COG1252@2|Bacteria,1N2QQ@1224|Proteobacteria,1RRBT@1236|Gammaproteobacteria,1YR5H@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	C	pyridine nucleotide-disulfide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_357851_1	414684.RC1_3125	1.14e-38	140.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,2JPI5@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0765 ABC-type amino acid transport system, permease component	-	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_357851_2	1123355.JHYO01000029_gene3753	8.42e-13	67.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,36XA4@31993|Methylocystaceae	28211|Alphaproteobacteria	E	ABC transporter	bztD	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
k59_226498_1	349965.yinte0001_23440	9.58e-34	133.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,41DK9@629|Yersinia	1236|Gammaproteobacteria	KT	formate hydrogenlyase transcriptional activator	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
k59_129565_1	1123392.AQWL01000004_gene2505	4.77e-87	262.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,1KRF6@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_495505_2	1049564.TevJSym_ac00140	5.37e-18	88.2	COG1999@1|root,COG4531@1|root,COG1999@2|Bacteria,COG4531@2|Bacteria,1RHJ8@1224|Proteobacteria,1SYEA@1236|Gammaproteobacteria,1J6I1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC,ZnuA
k59_691315_1	1232683.ADIMK_0084	1.99e-111	342.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,464A6@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_723817_1	330214.NIDE1304	2.31e-188	562.0	COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_331912_1	85643.Tmz1t_3997	5.36e-32	118.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,2KX2W@206389|Rhodocyclales	206389|Rhodocyclales	P	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
k59_331912_2	1366050.N234_24930	3.42e-05	47.4	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1K8SG@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
k59_461613_1	232721.Ajs_0714	4.11e-13	68.6	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,4AC09@80864|Comamonadaceae	28216|Betaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
k59_461613_2	1517681.HW45_14765	2.51e-50	168.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1XUE9@135623|Vibrionales	135623|Vibrionales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_495509_1	1265505.ATUG01000002_gene1479	3.61e-113	337.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,42MQU@68525|delta/epsilon subdivisions,2WK6F@28221|Deltaproteobacteria,2MN1R@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_298955_1	293826.Amet_3574	2.07e-22	100.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,36G29@31979|Clostridiaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_298962_1	47839.CCAU010000011_gene5762	9.2e-10	59.7	COG2159@1|root,COG2159@2|Bacteria,2GP75@201174|Actinobacteria,235H7@1762|Mycobacteriaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
k59_136217_1	1565129.JSFF01000005_gene2377	1.18e-25	102.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,2QAGH@267890|Shewanellaceae	1236|Gammaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iPC815.YPO3361,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300	IspD
k59_136217_2	1178482.BJB45_03070	2.89e-46	153.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1XJPI@135619|Oceanospirillales	135619|Oceanospirillales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_5571_1	319003.Bra1253DRAFT_04694	1.62e-22	101.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,2TV9Y@28211|Alphaproteobacteria,3JSX0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
k59_526756_1	1229909.NSED_09695	4.06e-29	104.0	arCOG11529@1|root,arCOG11529@2157|Archaea,41TAA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_526756_2	436308.Nmar_0011	1.75e-33	128.0	COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_625757_1	1198452.Jab_2c20670	1.44e-08	59.7	COG3637@1|root,COG3637@2|Bacteria,1NIE3@1224|Proteobacteria,2VXMU@28216|Betaproteobacteria,478B6@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	OmpA-like transmembrane domain	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA_membrane
k59_396469_1	643867.Ftrac_1007	9.65e-09	60.5	COG0642@1|root,COG1835@1|root,COG1835@2|Bacteria,COG2205@2|Bacteria,4NN26@976|Bacteroidetes	976|Bacteroidetes	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA
k59_331942_1	471854.Dfer_1489	7.84e-34	138.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,47JBS@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_136232_1	1288494.EBAPG3_21040	1.49e-103	332.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VHNB@28216|Betaproteobacteria,371VU@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_919882_1	1121918.ARWE01000001_gene3332	3.61e-36	130.0	COG4393@1|root,COG4393@2|Bacteria,1R507@1224|Proteobacteria,42NQA@68525|delta/epsilon subdivisions,2WQ0C@28221|Deltaproteobacteria,43VBI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
k59_723860_1	314345.SPV1_07861	2.75e-29	116.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria	1224|Proteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009507,GO:0009536,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125	GATase_6,GATase_7,Pribosyltran
k59_821959_1	640511.BC1002_1415	2.24e-75	232.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,1K319@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyhydroxyalkanoate synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
k59_821959_2	1131553.JIBI01000010_gene1351	5.23e-77	242.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,372H1@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_854107_1	1123020.AUIE01000015_gene821	1.11e-09	62.8	COG2207@1|root,COG2207@2|Bacteria,1R53W@1224|Proteobacteria,1RZCR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
k59_5598_1	880071.Fleli_0252	4.74e-29	119.0	COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,47KKB@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_691359_2	713586.KB900536_gene2631	2.99e-38	130.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1WYSF@135613|Chromatiales	135613|Chromatiales	P	PFAM ApaG domain protein	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_495550_1	748658.KB907313_gene2216	3.76e-37	132.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1WX98@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
k59_71055_1	335283.Neut_1429	1.02e-126	385.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,372EP@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_593222_1	926569.ANT_24670	8.59e-94	283.0	COG0667@1|root,COG0667@2|Bacteria,2G6BF@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_495556_1	882378.RBRH_02063	4.98e-10	59.7	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,1K2TQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_821973_1	365046.Rta_17000	2.79e-46	157.0	COG3963@1|root,COG3963@2|Bacteria,1N1KB@1224|Proteobacteria,2VTPN@28216|Betaproteobacteria,4AEPX@80864|Comamonadaceae	28216|Betaproteobacteria	I	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_854119_1	1266925.JHVX01000002_gene781	1.33e-104	323.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VJEM@28216|Betaproteobacteria,372NW@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_755434_1	1229909.NSED_08150	1.84e-90	270.0	COG0311@1|root,arCOG00034@2157|Archaea,41SIZ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
k59_560742_1	1232410.KI421421_gene3691	8.12e-88	286.0	COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,43BKE@68525|delta/epsilon subdivisions,2X6YE@28221|Deltaproteobacteria,43S2W@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Biotin carboxylase C-terminal domain	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
k59_1014438_1	375286.mma_2347	1.56e-73	233.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,476TX@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	CoA-transferase family III	-	-	2.8.3.16,2.8.3.22	ko:K07749,ko:K14471,ko:K14472	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R00406,R03154	RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_396500_1	1487953.JMKF01000053_gene1705	1.45e-37	139.0	COG1600@1|root,COG1600@2|Bacteria,1G007@1117|Cyanobacteria,1H7UP@1150|Oscillatoriales	1117|Cyanobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_299014_1	1245469.S58_06180	5.18e-16	82.4	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2TUAE@28211|Alphaproteobacteria,3JWMX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the 5'-nucleotidase family	MA20_22840	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C,Metallophos
k59_168857_1	1187851.A33M_1768	1.61e-32	122.0	COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,2U3GA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
k59_919918_1	1034347.CAHJ01000040_gene4401	3.86e-07	53.1	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H9WY@91061|Bacilli,1ZB2E@1386|Bacillus	91061|Bacilli	E	COG1126 ABC-type polar amino acid transport system, ATPase component	glnQ_2	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k59_919918_2	1297863.APJF01000019_gene2418	1.71e-15	79.3	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2TTC6@28211|Alphaproteobacteria,3JSJ8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_266740_1	1395571.TMS3_0121565	1.46e-26	115.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Type I secretion membrane fusion protein, HlyD	hasE	-	-	ko:K02022,ko:K12537	-	M00328	-	-	ko00000,ko00002,ko02000,ko02044	8.A.1	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
k59_168875_1	1122194.AUHU01000002_gene2510	1.82e-44	153.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1T08M@1236|Gammaproteobacteria,46D0G@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_952365_2	1288494.EBAPG3_1430	4.21e-83	252.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,3720E@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Ribosomal RNA adenine dimethylase	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_625819_1	1123489.AUAN01000019_gene1516	2.25e-67	229.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,4H24W@909932|Negativicutes	909932|Negativicutes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_984660_1	555387.C7BV61_9CAUD	5.13e-46	163.0	4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses  no RNA stage,4QPEB@28883|Caudovirales	28883|Caudovirales	S	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_919933_1	1170562.Cal6303_0240	1.19e-127	381.0	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1HU7J@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_20
k59_103571_1	1123393.KB891327_gene310	1.38e-200	560.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2VKR0@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
k59_103571_2	1123393.KB891327_gene309	9.45e-68	214.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2W93N@28216|Betaproteobacteria,1KTHC@119069|Hydrogenophilales	1224|Proteobacteria	Q	ubiE/COQ5 methyltransferase family	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_560781_1	1415756.JQMY01000001_gene3477	5.91e-40	144.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2TWCZ@28211|Alphaproteobacteria,2PDBJ@252301|Oceanicola	28211|Alphaproteobacteria	CI	Phosphate acetyl/butaryl transferase	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_691413_1	339670.Bamb_1597	0.000194	46.2	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_9,Response_reg,dCache_1
k59_691413_2	159087.Daro_2388	1.14e-27	106.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2VUF2@28216|Betaproteobacteria,2KWY2@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
k59_658804_1	909663.KI867151_gene3132	4.65e-58	195.0	COG0774@1|root,COG2204@1|root,COG0774@2|Bacteria,COG2204@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria,2MRFZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	MT	UDP-3-O-acyl N-acetylglycosamine deacetylase	lpxC	-	3.5.1.108	ko:K02535,ko:K13599	ko00540,ko01100,ko02020,map00540,map01100,map02020	M00060,M00498	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005,ko02022	-	-	-	LpxC
k59_560782_1	1123367.C666_15445	3.35e-81	263.0	28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,2VK1A@28216|Betaproteobacteria,2KVYD@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_691417_1	1229909.NSED_08500	9.75e-111	354.0	arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1014459_1	1304883.KI912532_gene865	1.6e-80	256.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,2VKHA@28216|Betaproteobacteria,2KUFX@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_cB
k59_103579_1	292415.Tbd_1463	7.11e-23	89.4	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,1KTBN@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Translation initiation factor 1A / IF-1	-	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_658811_1	1530186.JQEY01000002_gene1720	5.91e-37	130.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
k59_625830_1	330214.NIDE0866	5.88e-05	44.3	COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae	40117|Nitrospirae	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_625830_2	330214.NIDE0867	2.48e-102	308.0	COG4775@1|root,COG4775@2|Bacteria,3J10P@40117|Nitrospirae	40117|Nitrospirae	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
k59_560790_1	1198452.Jab_1c04430	1.19e-32	122.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_560790_2	1100721.ALKO01000019_gene1405	1.43e-30	110.0	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,4AEQV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulphur oxidation protein SoxZ	soxZ	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
k59_984681_1	305700.B447_19784	3.63e-145	422.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,2KUZ8@206389|Rhodocyclales	206389|Rhodocyclales	H	Coenzyme F390 synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
k59_39242_2	981336.F944_02114	4.96e-07	52.4	COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1SAFA@1236|Gammaproteobacteria,3NMFC@468|Moraxellaceae	1236|Gammaproteobacteria	S	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
k59_659836_1	1288494.EBAPG3_22420	3.52e-172	494.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,372CV@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_659836_2	1288494.EBAPG3_22410	8.6e-51	165.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2VSRT@28216|Betaproteobacteria,37338@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_887482_1	279714.FuraDRAFT_2876	2.35e-40	139.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,2VITY@28216|Betaproteobacteria,2KQBN@206351|Neisseriales	206351|Neisseriales	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_887482_2	1120999.JONM01000023_gene3186	2.92e-50	164.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria,2KRJ1@206351|Neisseriales	206351|Neisseriales	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_887482_3	572477.Alvin_1018	1.13e-26	107.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1WWWV@135613|Chromatiales	135613|Chromatiales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_785653_1	1254432.SCE1572_28450	9.57e-29	119.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42RS8@68525|delta/epsilon subdivisions,2WND0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Group II intron maturase-specific domain protein	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_887483_1	945713.IALB_0230	1.56e-49	172.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	hemG	-	1.14.19.9,1.3.3.15,1.3.3.4	ko:K00231,ko:K14266	ko00404,ko00860,ko01100,ko01110,ko01130,map00404,map00860,map01100,map01110,map01130	M00121,M00789,M00790	R03222,R04178,R09570	RC00885,RC00949	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09325	Amino_oxidase
k59_724938_1	391626.OAN307_c03800	2.45e-170	488.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_855156_1	999541.bgla_1g36990	6.03e-92	281.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,1K0VF@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_659848_1	713587.THITH_05055	3.44e-52	184.0	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2FP@1236|Gammaproteobacteria,1WWXW@135613|Chromatiales	135613|Chromatiales	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2
k59_887484_2	1385935.N836_16965	2.63e-17	90.5	COG0454@1|root,COG0456@2|Bacteria,1G0HU@1117|Cyanobacteria,1H7PR@1150|Oscillatoriales	1117|Cyanobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_929243_1	1212548.B381_15273	3.51e-66	214.0	COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,1S2HE@1236|Gammaproteobacteria,1Z2KN@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_733366_1	983917.RGE_25300	1.2e-88	278.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,1KKDF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	acetolactate synthase	xsc	-	2.2.1.6,2.3.3.15,4.1.1.8	ko:K01577,ko:K01652,ko:K03852	ko00290,ko00430,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00430,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01908,R03050,R04672,R04673,R05651,R08648	RC00027,RC00106,RC00620,RC01192,RC02744,RC02893,RC02903,RC02909	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_788457_1	1122214.AQWH01000001_gene851	6.83e-58	193.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2PKH2@255475|Aurantimonadaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_700958_1	448385.sce0890	1.94e-10	66.2	COG1181@1|root,COG3191@1|root,COG1181@2|Bacteria,COG3191@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,2YU6C@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_929258_1	1205753.A989_09753	7.09e-75	236.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X3IG@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_373210_1	980584.AFPB01000138_gene2681	7.42e-28	109.0	COG1017@1|root,COG1017@2|Bacteria,4PK8Z@976|Bacteroidetes,1IEWB@117743|Flavobacteriia,40777@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	C	Globin	-	-	-	-	-	-	-	-	-	-	-	-	Globin
k59_373210_2	272560.BPSL2008	4.97e-11	62.4	COG0583@1|root,COG0583@2|Bacteria,1N8HZ@1224|Proteobacteria,2VJGT@28216|Betaproteobacteria,1JZQT@119060|Burkholderiaceae	28216|Betaproteobacteria	K	transcriptional Regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_438494_1	903818.KI912269_gene77	1.07e-19	87.0	COG1102@1|root,COG1102@2|Bacteria,3Y50F@57723|Acidobacteria	57723|Acidobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
k59_504820_1	1126627.BAWE01000004_gene1851	2.71e-97	320.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JVPA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF
k59_112776_1	1234364.AMSF01000001_gene2351	1.6e-32	122.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,1R6F1@1224|Proteobacteria,1S4IC@1236|Gammaproteobacteria,1X62F@135614|Xanthomonadales	135614|Xanthomonadales	P	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
k59_47311_1	1348657.M622_07915	5.96e-47	162.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,2KUHC@206389|Rhodocyclales	206389|Rhodocyclales	I	Squalene synthase HpnD	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_47311_2	1123377.AUIV01000012_gene706	4.5e-05	48.1	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1X3DA@135614|Xanthomonadales	135614|Xanthomonadales	T	Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_993533_1	1123392.AQWL01000007_gene931	9.14e-68	226.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,1KRH7@119069|Hydrogenophilales	119069|Hydrogenophilales	KQ	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,Sigma54_activat
k59_993533_2	1123393.KB891326_gene216	3e-26	101.0	COG1036@1|root,COG1036@2|Bacteria,1RD5I@1224|Proteobacteria,2VQ1A@28216|Betaproteobacteria,1KSD9@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
k59_863016_1	395495.Lcho_3053	1.13e-18	88.6	COG3107@1|root,COG3107@2|Bacteria,1NBKY@1224|Proteobacteria,2VXD7@28216|Betaproteobacteria,1KNHB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	peptidoglycan biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_307491_1	1235798.C817_05291	6.72e-100	308.0	COG1321@1|root,COG1321@2|Bacteria,1UZX6@1239|Firmicutes,248DA@186801|Clostridia	186801|Clostridia	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_895169_3	1288494.EBAPG3_4510	7.14e-16	77.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,372JX@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_438505_1	748247.AZKH_0507	1.03e-92	289.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KV59@206389|Rhodocyclales	206389|Rhodocyclales	I	poly(R)-hydroxyalkanoic acid synthase	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_993537_1	543728.Vapar_5714	1.31e-23	99.4	COG0604@1|root,COG0604@2|Bacteria,1QSVA@1224|Proteobacteria	1224|Proteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_993537_2	762376.AXYL_02289	6e-06	49.3	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJ08@28216|Betaproteobacteria,3T5HZ@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_80452_1	1385517.N800_05265	7.86e-108	331.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1X445@135614|Xanthomonadales	135614|Xanthomonadales	C	2,4-dienoyl-coa reductase	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_570104_1	234267.Acid_4640	2.21e-59	192.0	COG1682@1|root,COG1682@2|Bacteria,3Y7JV@57723|Acidobacteria	57723|Acidobacteria	GM	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
k59_210298_1	156889.Mmc1_0002	2.39e-47	167.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1019216_1	243231.GSU1242	2.51e-66	214.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,43TQ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM aminotransferase, class I and II	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_403931_1	1229909.NSED_01240	6.67e-133	381.0	COG0483@1|root,arCOG01349@2157|Archaea,41SIF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_273824_1	1502770.JQMG01000001_gene2416	1.15e-44	164.0	COG2304@1|root,COG2931@1|root,COG3898@1|root,COG5295@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3898@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,2KNPI@206350|Nitrosomonadales	206350|Nitrosomonadales	Q	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VWA_2
k59_863032_1	228410.NE1013	1e-119	348.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,372K7@32003|Nitrosomonadales	28216|Betaproteobacteria	C	cytochrome c oxidase, subunit III	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_403933_1	330214.NIDE0568	3.63e-114	351.0	COG0178@1|root,COG0178@2|Bacteria,3J0C7@40117|Nitrospirae	40117|Nitrospirae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_895182_1	1207063.P24_18556	2.27e-75	236.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,2JQNJ@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_895182_2	1121033.AUCF01000010_gene4559	8.93e-13	64.7	2C07J@1|root,32SWS@2|Bacteria,1N0NW@1224|Proteobacteria,2UCVR@28211|Alphaproteobacteria,2JTB5@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_602436_1	927658.AJUM01000040_gene841	2.7e-71	221.0	COG0088@1|root,COG0088@2|Bacteria,4NEWZ@976|Bacteroidetes,2FM1W@200643|Bacteroidia,3XJIB@558415|Marinilabiliaceae	976|Bacteroidetes	J	Ribosomal protein L4/L1 family	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_570122_1	247634.GPB2148_291	9.59e-17	79.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	enzyme of heme biosynthesis	hemY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_2
k59_570122_2	314285.KT71_07099	2.36e-34	130.0	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1J8ZX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	HemX, putative uroporphyrinogen-III C-methyltransferase	hemX	-	2.1.1.107,4.2.1.75	ko:K02496,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iPC815.YPO3851,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317	HemX
k59_863037_2	349521.HCH_00541	8.17e-61	211.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XHMP@135619|Oceanospirillales	135619|Oceanospirillales	T	Chemotaxis protein histidine kinase and related	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_668219_2	1528106.JRJE01000021_gene32	2.57e-13	70.5	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JQGA@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_403941_1	349521.HCH_01459	7.14e-55	183.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1XS39@135619|Oceanospirillales	135619|Oceanospirillales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_273830_1	1033802.SSPSH_002089	7.78e-95	302.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_145480_1	264462.Bd0967	3.72e-51	181.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42NID@68525|delta/epsilon subdivisions,2MSNJ@213481|Bdellovibrionales,2WJ4P@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
k59_47348_1	85643.Tmz1t_3378	5.42e-73	245.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales	206389|Rhodocyclales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_831543_1	398767.Glov_3556	3.22e-15	80.5	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,43BRF@68525|delta/epsilon subdivisions,2WKAH@28221|Deltaproteobacteria,43TV7@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TonB dependent receptor	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_112824_1	187272.Mlg_0110	7.43e-10	60.1	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,1RZ5C@1236|Gammaproteobacteria,1WX9Q@135613|Chromatiales	135613|Chromatiales	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_112824_2	187272.Mlg_0134	1.25e-31	124.0	COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,1RNBE@1236|Gammaproteobacteria,1WW7I@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_831545_1	1322246.BN4_11774	1.72e-13	69.3	COG2206@1|root,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,43D1I@68525|delta/epsilon subdivisions,2X89H@28221|Deltaproteobacteria,2M83Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
k59_373265_1	330214.NIDE1420	7.59e-62	215.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,PA14
k59_273834_2	1101195.Meth11DRAFT_1181	1.43e-21	88.2	COG2965@1|root,COG2965@2|Bacteria,1N98W@1224|Proteobacteria,2VVZ4@28216|Betaproteobacteria,2KN9V@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Binds single-stranded DNA at the primosome assembly site (PAS)	priB	-	-	ko:K02686	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SSB
k59_273834_3	497321.C664_17937	3.51e-67	206.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2VR79@28216|Betaproteobacteria,2KWGN@206389|Rhodocyclales	206389|Rhodocyclales	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
k59_240734_1	1163617.SCD_n00952	3.91e-118	352.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_602463_1	330214.NIDE0444	3.37e-139	399.0	COG2519@1|root,COG2519@2|Bacteria,3J0PT@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
k59_16154_1	580332.Slit_1368	6.13e-40	149.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,44V80@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
k59_113807_1	1121405.dsmv_2962	2.91e-63	208.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,42M2V@68525|delta/epsilon subdivisions,2WKEB@28221|Deltaproteobacteria,2MISW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Putative RNA methylase family UPF0020	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
k59_734479_1	340177.Cag_1725	5.77e-57	197.0	COG3158@1|root,COG3158@2|Bacteria,1FEIA@1090|Chlorobi	1090|Chlorobi	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_308449_1	91464.S7335_3138	2.51e-31	126.0	COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,1H06I@1129|Synechococcus	1117|Cyanobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
k59_763780_1	994573.T472_0214340	2.21e-23	97.8	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24DKH@186801|Clostridia,36DYF@31979|Clostridiaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_763780_2	401526.TcarDRAFT_0706	3.05e-88	266.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,4H3JN@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_146495_1	270374.MELB17_17884	1.1e-68	218.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,464XH@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0714 MoxR-like ATPases	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_788840_1	497321.C664_19356	2.3e-28	112.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2VKR0@28216|Betaproteobacteria,2KZS6@206389|Rhodocyclales	206389|Rhodocyclales	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
k59_179037_2	1121937.AUHJ01000004_gene1013	5.82e-78	246.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1T7KM@1236|Gammaproteobacteria,46C37@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_864105_1	768704.Desmer_0358	6.35e-29	114.0	COG2120@1|root,COG2120@2|Bacteria,1TPSJ@1239|Firmicutes,24NQN@186801|Clostridia	186801|Clostridia	S	PFAM GlcNAc-PI de-N-acetylase	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_81540_2	1217710.F969_00611	2.84e-13	72.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,3NN1F@468|Moraxellaceae	1236|Gammaproteobacteria	D	VirC1 protein	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,MipZ
k59_763786_1	1480694.DC28_01970	5.48e-57	201.0	COG0209@1|root,COG0209@2|Bacteria	2|Bacteria	F	ribonucleoside-diphosphate reductase activity	rtpR	-	1.1.98.6,1.17.4.1	ko:K00525,ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC
k59_469917_2	305900.GV64_00785	4.01e-21	89.0	2CKE6@1|root,32ZEV@2|Bacteria,1NBRM@1224|Proteobacteria,1SCY3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Family of unknown function (DUF5329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5329
k59_48347_1	457424.BFAG_04159	1.99e-76	240.0	COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,2FMMZ@200643|Bacteroidia,4ATQR@815|Bacteroidaceae	976|Bacteroidetes	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
k59_439555_1	1265502.KB905929_gene2257	2.26e-148	423.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2VHC8@28216|Betaproteobacteria,4AA24@80864|Comamonadaceae	28216|Betaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_930398_2	292415.Tbd_0664	8.02e-30	114.0	COG0517@1|root,COG0517@2|Bacteria,1RJTX@1224|Proteobacteria,2VTQI@28216|Betaproteobacteria,1KRSH@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_308487_1	945713.IALB_0499	1.78e-18	82.0	COG2825@1|root,COG2825@2|Bacteria	2|Bacteria	M	unfolded protein binding	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_308487_2	945713.IALB_0499	8.94e-23	92.4	COG2825@1|root,COG2825@2|Bacteria	2|Bacteria	M	unfolded protein binding	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_603475_1	1101189.AQUO01000002_gene772	2.3e-19	92.4	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,2PUHP@265|Paracoccus	28211|Alphaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
k59_832666_1	329726.AM1_6085	2.09e-49	177.0	COG2909@1|root,COG2909@2|Bacteria,1G3UH@1117|Cyanobacteria	1117|Cyanobacteria	K	ATP-dependent transcriptional regulator	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_81561_1	326442.PSHAa1036	4.31e-67	215.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,1S5UD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_994608_1	5022.CBX94134	6.43e-11	65.9	COG0659@1|root,KOG0236@2759|Eukaryota,38C1D@33154|Opisthokonta,3NVZY@4751|Fungi,3QNB6@4890|Ascomycota,204RT@147541|Dothideomycetes,4KF0Q@92860|Pleosporales	4751|Fungi	P	STAS domain	-	-	-	ko:K14708	-	-	-	-	ko00000,ko02000	2.A.53.1	-	-	STAS,Sulfate_transp
k59_994608_2	439235.Dalk_3362	2.51e-16	78.2	COG0427@1|root,COG0427@2|Bacteria,1NVAY@1224|Proteobacteria,42ZS2@68525|delta/epsilon subdivisions,2WUYX@28221|Deltaproteobacteria,2MN92@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
k59_571218_1	573370.DMR_29900	3.69e-19	96.3	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
k59_864145_1	1123504.JQKD01000002_gene3679	2.38e-101	299.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VJNC@28216|Betaproteobacteria,4ABEP@80864|Comamonadaceae	28216|Betaproteobacteria	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_48382_1	261292.Nit79A3_3148	4.95e-61	196.0	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,2VN69@28216|Betaproteobacteria,372KX@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM Zinc iron permease	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
k59_48382_2	1234364.AMSF01000024_gene3792	3.09e-43	149.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1X34B@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_315688_1	933262.AXAM01000007_gene2042	3.68e-84	266.0	COG1219@1|root,COG1219@2|Bacteria,1MWIZ@1224|Proteobacteria,42N1Z@68525|delta/epsilon subdivisions,2WJUS@28221|Deltaproteobacteria,2MHMD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the ClpX chaperone family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
k59_278360_1	330214.NIDE3711	1.06e-89	274.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_315689_1	391598.FBBAL38_01305	6.99e-29	114.0	COG1262@1|root,COG1262@2|Bacteria,4NEUZ@976|Bacteroidetes,1HYG0@117743|Flavobacteriia	976|Bacteroidetes	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
k59_248500_1	1357272.AVEO02000136_gene805	1.75e-06	56.2	COG1807@1|root,COG1807@2|Bacteria,1MXH5@1224|Proteobacteria,1RSQE@1236|Gammaproteobacteria,1Z9SX@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_24222_1	395495.Lcho_3778	1.08e-128	381.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1KK3V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the 5'-nucleotidase family	soxB	-	3.1.3.5,3.6.1.45	ko:K11751,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C
k59_742793_1	999541.bgla_1g34750	1.23e-81	266.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,1K1J9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_677609_1	1095769.CAHF01000021_gene943	7.86e-39	135.0	COG2755@1|root,COG2755@2|Bacteria,1MWT8@1224|Proteobacteria,2VVC1@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_643783_1	580332.Slit_2932	2.25e-79	244.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,44VME@713636|Nitrosomonadales	28216|Betaproteobacteria	F	PFAM aspartate ornithine carbamoyltransferase Asp Orn-binding region	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_710419_1	1236959.BAMT01000011_gene3139	8.62e-44	145.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2VR8I@28216|Betaproteobacteria,2KMK2@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_710419_2	640081.Dsui_0336	7.7e-34	119.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2VR2K@28216|Betaproteobacteria,2KWBI@206389|Rhodocyclales	206389|Rhodocyclales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_411770_1	257310.BB0539	1.59e-86	273.0	COG0028@1|root,COG0028@2|Bacteria,1MWC3@1224|Proteobacteria,2W1CG@28216|Betaproteobacteria,3T8R8@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_447285_1	436308.Nmar_0295	7.16e-136	400.0	COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
k59_186630_1	1411123.JQNH01000001_gene744	6.86e-70	220.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,2TVMD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the carbamate kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_219184_1	296591.Bpro_4866	1.62e-48	171.0	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2VKPZ@28216|Betaproteobacteria,4AB3E@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_579448_2	566466.NOR53_3466	7.12e-37	131.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,1RPGA@1236|Gammaproteobacteria,1J8PN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix ASNC type	lrp_2	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
k59_381834_1	1123392.AQWL01000001_gene1527	1.22e-38	146.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,1KRKB@119069|Hydrogenophilales	119069|Hydrogenophilales	NU	pilus assembly protein FimV	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	-
k59_381839_1	296591.Bpro_4805	1.23e-100	302.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_938658_1	1286631.X805_16900	2.99e-14	76.6	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VKTJ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_710455_1	1384056.N787_12740	3.33e-94	292.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1X3IH@135614|Xanthomonadales	135614|Xanthomonadales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_872155_1	420246.GTNG_3156	1.03e-35	132.0	COG2159@1|root,COG2159@2|Bacteria,1UZAH@1239|Firmicutes,4HA5S@91061|Bacilli,1WGUT@129337|Geobacillus	91061|Bacilli	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_1002419_2	397945.Aave_4159	9.58e-32	123.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VJSG@28216|Betaproteobacteria,4AC5S@80864|Comamonadaceae	28216|Betaproteobacteria	NU	PFAM type II secretion system	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_24272_1	1313304.CALK_0035	1.52e-53	183.0	COG0205@1|root,COG0205@2|Bacteria	2|Bacteria	G	6-phosphofructokinase activity	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_514128_1	435908.IDSA_01430	4.22e-86	268.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,2QG08@267893|Idiomarinaceae	1236|Gammaproteobacteria	U	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_447321_1	1125863.JAFN01000001_gene2600	1.11e-71	234.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria	1224|Proteobacteria	C	PFAM FAD linked oxidase domain protein	dld	GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.1.1.303,1.1.1.4,1.1.2.4,1.1.3.15	ko:K00004,ko:K00102,ko:K00104	ko00620,ko00630,ko00650,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map00650,map01100,map01110,map01120,map01130	-	R00197,R00475,R02855,R02946,R10504	RC00042,RC00044,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_89825_1	977880.RALTA_A2720	4.9e-82	267.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,1K0RR@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_381863_1	330214.NIDE3482	5.04e-76	237.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_742845_1	1163617.SCD_n01822	4.44e-110	334.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_677669_1	243159.AFE_2321	1.23e-102	311.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,1SZ0Z@1236|Gammaproteobacteria,2NCM2@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_89829_1	1232410.KI421414_gene2863	1.81e-07	51.6	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,43UQ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	TIGRFAM D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
k59_89829_2	1379698.RBG1_1C00001G1309	6.61e-46	162.0	COG0297@1|root,COG0297@2|Bacteria,2NP1F@2323|unclassified Bacteria	2|Bacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_611493_1	671143.DAMO_1933	2.06e-122	383.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1023680_1	1231391.AMZF01000063_gene1101	1.73e-124	366.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2W97H@28216|Betaproteobacteria,3T2I7@506|Alcaligenaceae	28216|Betaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_315763_1	522306.CAP2UW1_3026	2.48e-89	271.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,1KPQ9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_381879_1	1218076.BAYB01000012_gene2603	1.15e-08	55.8	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2VSHT@28216|Betaproteobacteria,1K3V0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
k59_381879_2	216591.BCAL0830	6.84e-83	253.0	COG1192@1|root,COG1192@2|Bacteria,1MVEZ@1224|Proteobacteria,2VK7W@28216|Betaproteobacteria,1K50X@119060|Burkholderiaceae	28216|Betaproteobacteria	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_316529_1	945713.IALB_2343	2.52e-58	199.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	ppiD	-	5.2.1.8	ko:K01802,ko:K03769,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
k59_249347_1	1449065.JMLL01000012_gene3738	3.26e-105	321.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2U1RU@28211|Alphaproteobacteria,43MQW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Predicted Permease Membrane Region	-	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex,TrkA_C
k59_1024102_1	1231391.AMZF01000063_gene1104	2.36e-187	540.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria	1224|Proteobacteria	E	ethanolamine utilization protein	eutA	GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
k59_1024102_2	1463857.JOFZ01000007_gene163	1.96e-97	297.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_711367_1	1128421.JAGA01000004_gene2536	4.97e-13	74.3	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_678575_1	1502724.FF80_00656	2.72e-40	144.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2UQ7P@28211|Alphaproteobacteria,3N840@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_743769_1	102125.Xen7305DRAFT_00005600	4.28e-26	114.0	COG3264@1|root,COG3264@2|Bacteria,1G09S@1117|Cyanobacteria,3VM9I@52604|Pleurocapsales	1117|Cyanobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_351029_1	1244869.H261_21029	1.44e-24	97.4	COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2U6JY@28211|Alphaproteobacteria,2JTDY@204441|Rhodospirillales	204441|Rhodospirillales	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_351029_2	296591.Bpro_3115	2.04e-64	199.0	COG0824@1|root,COG0824@2|Bacteria,1RG6B@1224|Proteobacteria,2VTAU@28216|Betaproteobacteria,4ADWM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Thioesterase-like superfamily	-	-	3.1.2.23	ko:K01075	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT,4HBT_2
k59_220085_1	207954.MED92_06068	2.18e-85	267.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,1RNV5@1236|Gammaproteobacteria,1XI37@135619|Oceanospirillales	135619|Oceanospirillales	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta	-	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_580419_2	1286632.P278_03710	1.24e-21	87.8	COG2044@1|root,COG2044@2|Bacteria,4P2I4@976|Bacteroidetes,1I8SH@117743|Flavobacteriia	976|Bacteroidetes	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_536386_1	991905.SL003B_1827	2.23e-108	335.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,4BPK2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_351034_1	515635.Dtur_0873	7.54e-62	213.0	COG2804@1|root,COG2804@2|Bacteria	2|Bacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	ctsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_711379_1	522306.CAP2UW1_2298	2.85e-67	214.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator crp fnr family	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_25156_1	491952.Mar181_1152	0.000148	44.7	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1XHQS@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_25156_2	159087.Daro_2709	5.69e-25	95.9	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,2VWCN@28216|Betaproteobacteria,2KXGA@206389|Rhodocyclales	206389|Rhodocyclales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
k59_25156_3	1366050.N234_08610	6.55e-47	154.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2VN6N@28216|Betaproteobacteria	28216|Betaproteobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_743782_1	330214.NIDE0226	2.58e-87	273.0	COG1008@1|root,COG1008@2|Bacteria,3J0EQ@40117|Nitrospirae	2|Bacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	ndhD	-	1.6.5.3	ko:K00342,ko:K05575	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iJN678.ndhD2	Oxidored_q5_N,Proton_antipo_M
k59_743782_2	330214.NIDE0225	1.13e-25	105.0	COG1007@1|root,COG1007@2|Bacteria,3J0FN@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_904630_1	471854.Dfer_5393	2.22e-33	130.0	COG0587@1|root,COG0587@2|Bacteria,4NGTT@976|Bacteroidetes,47TPJ@768503|Cytophagia	976|Bacteroidetes	L	DNA polymerase alpha chain like domain	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_249369_1	123899.JPQP01000019_gene2711	1.87e-32	125.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2W9AM@28216|Betaproteobacteria,3T71C@506|Alcaligenaceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_939595_1	267608.RSc0923	7.57e-67	210.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VHXJ@28216|Betaproteobacteria,1K18X@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_412674_1	1454004.AW11_03212	8.45e-151	437.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria,1KR2K@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	C-terminal region of aryl-sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
k59_122791_1	1341679.P253_01102	0.000552	44.3	COG3431@1|root,COG3431@2|Bacteria,1RM5Y@1224|Proteobacteria,1T2Z6@1236|Gammaproteobacteria,3NTNQ@468|Moraxellaceae	1236|Gammaproteobacteria	S	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
k59_56890_1	317936.Nos7107_3925	0.000331	48.1	COG0577@1|root,COG0577@2|Bacteria,1G20M@1117|Cyanobacteria,1HIN8@1161|Nostocales	1117|Cyanobacteria	V	TIGRFAM DevC protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_155557_1	566466.NOR53_946	5.68e-32	128.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1J4CD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_678605_1	1121011.AUCB01000018_gene4088	6.47e-58	198.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,PATR,PPC,Peptidase_S8
k59_25174_1	1132855.KB913035_gene2334	6.62e-26	107.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,2KNE7@206350|Nitrosomonadales	206350|Nitrosomonadales	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD_5
k59_25174_2	580332.Slit_0536	1.1e-39	147.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,44VNC@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	General secretory system II protein E domain protein	-	-	-	ko:K02454,ko:K02652,ko:K12276	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GAF,T2SSE,T2SSE_N
k59_477669_1	76114.ebA1260	1.07e-14	74.3	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,2KUKY@206389|Rhodocyclales	206389|Rhodocyclales	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_477669_2	987059.RBXJA2T_17926	5.65e-21	92.4	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,2VSHE@28216|Betaproteobacteria,1KKMF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
k59_1003302_1	883.DvMF_0984	1.93e-77	252.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2M7R9@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_515074_1	1502852.FG94_03395	5.68e-16	82.8	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,473G4@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	Peptidase C39 family	cvaB	-	-	ko:K13409	ko02010,ko04626,map02010,map04626	M00339	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.110	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_187559_1	477184.KYC_10918	3.46e-89	282.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,3T2UE@506|Alcaligenaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA	-	-	ko:K13892	ko02010,map02010	M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.11	-	-	ABC_tran,oligo_HPY
k59_580455_1	517418.Ctha_1908	2.34e-24	106.0	COG4775@1|root,COG4775@2|Bacteria,1FEGD@1090|Chlorobi	1090|Chlorobi	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
k59_122814_1	883126.HMPREF9710_01349	1.29e-44	155.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2VMCK@28216|Betaproteobacteria,474CU@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_122814_2	522306.CAP2UW1_0203	1.29e-43	144.0	COG2963@1|root,COG2963@2|Bacteria,1RKHT@1224|Proteobacteria,2VUSQ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_220120_1	519989.ECTPHS_02084	7.2e-24	95.1	COG0071@1|root,COG0071@2|Bacteria,1RH6E@1224|Proteobacteria,1S6FC@1236|Gammaproteobacteria,1WYSM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_972288_1	1304883.KI912532_gene360	1.45e-74	236.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,2KW35@206389|Rhodocyclales	206389|Rhodocyclales	K	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
k59_155574_1	395495.Lcho_0762	1.62e-113	330.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,1KJ0T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_873052_2	1163617.SCD_n00979	1.95e-27	105.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,2VY9Z@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM zinc finger, DksA TraR C4-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_515088_1	980584.AFPB01000180_gene2793	7.14e-05	47.4	COG2755@1|root,COG2755@2|Bacteria,4NGTK@976|Bacteroidetes,1HY1A@117743|Flavobacteriia,406UD@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	E	G-D-S-L family lipolytic protein	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL
k59_25201_1	1487953.JMKF01000006_gene5651	3.04e-43	146.0	COG3238@1|root,COG3238@2|Bacteria	2|Bacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
k59_56920_1	1379698.RBG1_1C00001G1741	6.11e-06	48.5	COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria	2|Bacteria	U	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_130392_2	1205680.CAKO01000026_gene4597	3.9e-08	54.3	COG2128@1|root,COG2128@2|Bacteria,1RC52@1224|Proteobacteria,2U3FR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_483958_1	1322246.BN4_11903	9.07e-111	328.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,42NEN@68525|delta/epsilon subdivisions,2WK9G@28221|Deltaproteobacteria,2MAGX@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_911805_2	330214.NIDE4318	2.03e-86	283.0	COG1197@1|root,COG1197@2|Bacteria,3J0BA@40117|Nitrospirae	40117|Nitrospirae	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_619747_1	1149133.ppKF707_1031	5.73e-84	261.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1YEWV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	iYL1228.KPN_01464	M20_dimer,Peptidase_M20
k59_911811_1	264198.Reut_B4564	2.91e-88	272.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,1K405@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_130405_2	180281.CPCC7001_2114	1.29e-21	92.4	COG2326@1|root,COG2326@2|Bacteria,1G159@1117|Cyanobacteria,22TKN@167375|Cyanobium	1117|Cyanobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_652017_1	1457393.AZ09_06115	3.24e-51	178.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2JQAF@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_194999_1	765912.Thimo_2317	8.69e-81	270.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,1RNT0@1236|Gammaproteobacteria,1WVYD@135613|Chromatiales	135613|Chromatiales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_778506_1	1123393.KB891331_gene2962	5.54e-75	236.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,1KS5G@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_1028011_1	946483.Cenrod_1524	7.53e-37	136.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,4ACPK@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM DNA photolyase, FAD-binding	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_1028011_2	1265502.KB905941_gene2905	7.83e-31	120.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,4ABCW@80864|Comamonadaceae	28216|Betaproteobacteria	T	ATP-binding region, ATPase domain protein	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_64217_1	631454.N177_2369	7.03e-85	268.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,1JPCC@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_619775_1	56780.SYN_02274	1.93e-71	233.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MR5R@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_880349_2	107636.JQNK01000009_gene2333	8.6e-05	48.5	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2TUFR@28211|Alphaproteobacteria,36XR2@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_255922_2	911045.PSE_3902	5.44e-11	73.9	COG3378@1|root,COG3378@2|Bacteria,1R6CB@1224|Proteobacteria,2TTK6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Phage plasmid primase P4 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_390196_1	161156.JQKW01000003_gene897	6.72e-07	50.1	COG0473@1|root,COG0473@2|Bacteria,2GGUW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_390196_2	580332.Slit_1579	3.54e-16	79.3	COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1QU8R@1224|Proteobacteria,2WHYG@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_540323_1	402626.Rpic_3379	2.56e-36	140.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1K1A4@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefC	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_325863_1	1211114.ALIP01000084_gene1674	2.35e-22	97.8	COG2267@1|root,COG2267@2|Bacteria,1N2R9@1224|Proteobacteria,1T1K8@1236|Gammaproteobacteria,1X3DZ@135614|Xanthomonadales	135614|Xanthomonadales	I	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	-	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_325863_2	1288494.EBAPG3_21780	5.04e-56	187.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2VH25@28216|Betaproteobacteria,372XJ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1029145_1	32057.KB217478_gene4376	2.94e-73	230.0	COG1793@1|root,COG1793@2|Bacteria	2|Bacteria	L	dna ligase	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_913886_1	991905.SL003B_4136	6.32e-164	464.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,4BT5R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_3
k59_780513_1	765912.Thimo_3101	7.9e-59	196.0	COG2807@1|root,COG2807@2|Bacteria,1QW3Y@1224|Proteobacteria,1T2RW@1236|Gammaproteobacteria,1X2P1@135613|Chromatiales	135613|Chromatiales	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_284052_1	883126.HMPREF9710_01601	3.09e-114	340.0	COG1215@1|root,COG1215@2|Bacteria,1QUUY@1224|Proteobacteria,2WI2R@28216|Betaproteobacteria,475CU@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_284063_1	864051.BurJ1DRAFT_2853	5.86e-109	322.0	COG0687@1|root,COG0687@2|Bacteria,1MU0I@1224|Proteobacteria,2VICQ@28216|Betaproteobacteria,1KKHZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding protein	potD	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
k59_913920_2	305700.B447_05228	3.95e-51	169.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,2KUV5@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_485909_1	1453503.AU05_07230	1.72e-77	246.0	COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1YEX1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_325951_1	1504672.669785551	5.21e-30	120.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,4A9SK@80864|Comamonadaceae	28216|Betaproteobacteria	T	Signal transduction histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8
k59_1029179_1	96561.Dole_0364	3.32e-77	244.0	COG2006@1|root,COG2006@2|Bacteria,1R6CE@1224|Proteobacteria,42QI7@68525|delta/epsilon subdivisions,2WJA0@28221|Deltaproteobacteria,2MMMR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_257883_1	926569.ANT_04980	4.37e-30	111.0	COG3677@1|root,COG3677@2|Bacteria,2G9MB@200795|Chloroflexi	200795|Chloroflexi	L	Putative ATPase subunit of terminase (gpP-like)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
k59_325966_1	1321778.HMPREF1982_01733	6.2e-17	82.8	COG0398@1|root,COG0398@2|Bacteria,1V7NH@1239|Firmicutes,24HNU@186801|Clostridia,26930@186813|unclassified Clostridiales	186801|Clostridia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_326005_1	1095769.CAHF01000018_gene821	2.43e-11	64.3	COG4664@1|root,COG4665@1|root,COG4664@2|Bacteria,COG4665@2|Bacteria,1R4MZ@1224|Proteobacteria,2VJ2Q@28216|Betaproteobacteria,47290@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_326005_2	1380355.JNIJ01000010_gene1440	3.09e-33	127.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3JVBW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_421360_1	867903.ThesuDRAFT_00833	1.95e-23	100.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,3WCD8@538999|Clostridiales incertae sedis	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_485965_1	485913.Krac_8363	1.57e-23	97.1	COG1662@1|root,COG3677@1|root,COG1662@2|Bacteria,COG3677@2|Bacteria,2G9MB@200795|Chloroflexi	200795|Chloroflexi	L	Putative ATPase subunit of terminase (gpP-like)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
k59_326038_1	497321.C664_15393	1.25e-119	357.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2VIV3@28216|Betaproteobacteria,2KU7K@206389|Rhodocyclales	206389|Rhodocyclales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_780668_1	1282876.BAOK01000002_gene900	6.37e-64	207.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TTZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Zinc-binding dehydrogenase	MA20_17025	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_914033_1	522306.CAP2UW1_1192	2.24e-87	268.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VHZA@28216|Betaproteobacteria,1KQFE@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Branched-chain amino acid transport system / permease component	urtC	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_780679_1	157072.XP_008881372.1	2.14e-10	65.1	2DZRX@1|root,2S78Q@2759|Eukaryota	2759|Eukaryota	S	3'-5' exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_A_exo1
k59_780679_2	376686.Fjoh_1390	1.23e-09	57.0	COG3476@1|root,COG3476@2|Bacteria,4NP0D@976|Bacteroidetes,1I2B8@117743|Flavobacteriia,2NVX1@237|Flavobacterium	976|Bacteroidetes	T	TspO/MBR family	tspO	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
k59_485990_1	1144305.PMI02_03727	1.27e-17	87.0	COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U2UJ@28211|Alphaproteobacteria,2KEDN@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB-dependent receptor plug	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_326075_2	1229780.BN381_640017	6.96e-35	124.0	COG3631@1|root,COG3631@2|Bacteria,2IG87@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	SnoaL_2
k59_486009_1	1123377.AUIV01000012_gene708	9.2e-57	182.0	2E585@1|root,3300K@2|Bacteria,1N9MI@1224|Proteobacteria,1SDGZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_326082_1	1123070.KB899271_gene2357	4.5e-10	61.6	COG1595@1|root,COG1595@2|Bacteria,46SZG@74201|Verrucomicrobia,2IUFS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_914069_1	1209984.BN978_00693	1.97e-57	196.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,23555@1762|Mycobacteriaceae	201174|Actinobacteria	S	Reductase C-terminal	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
k59_780731_1	1266925.JHVX01000013_gene1612	1.08e-21	93.2	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,371VY@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Alanine dehydrogenase PNT	pntAA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_780731_2	335283.Neut_1192	6.03e-44	145.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,2VSM2@28216|Betaproteobacteria,373AX@32003|Nitrosomonadales	28216|Betaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntAb	-	1.6.1.1,1.6.1.2	ko:K00322,ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
k59_914100_1	113395.AXAI01000001_gene3194	9.55e-125	366.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria,3JTIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	aatA	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_914101_1	296591.Bpro_3017	2.82e-26	100.0	COG2010@1|root,COG2010@2|Bacteria,1N7JQ@1224|Proteobacteria,2VWM8@28216|Betaproteobacteria,4AEZW@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_914101_2	1121939.L861_03170	3.54e-21	92.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,1RP2M@1236|Gammaproteobacteria,1XICY@135619|Oceanospirillales	135619|Oceanospirillales	S	Mo-co oxidoreductase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_258028_1	439235.Dalk_4816	9.93e-68	222.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42QBH@68525|delta/epsilon subdivisions,2WISQ@28221|Deltaproteobacteria,2MIRA@213118|Desulfobacterales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,Phage_tail_X
k59_284179_1	335543.Sfum_2600	4.62e-20	89.4	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,2MSJJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_486058_1	1121405.dsmv_1218	8.53e-105	307.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,42MR4@68525|delta/epsilon subdivisions,2WM3M@28221|Deltaproteobacteria,2MMW9@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K02440,ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2	-	-	MIP
k59_258046_1	595460.RRSWK_04614	4.72e-81	253.0	COG1609@1|root,COG1609@2|Bacteria,2J0AF@203682|Planctomycetes	203682|Planctomycetes	K	COG1609 Transcriptional regulators	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_542246_1	220664.PFL_1707	1.07e-43	157.0	COG2267@1|root,COG2267@2|Bacteria,1MX2H@1224|Proteobacteria,1RRSX@1236|Gammaproteobacteria,1YPXM@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	serine threonine protein kinase	IV02_22745	-	-	-	-	-	-	-	-	-	-	-	-
k59_780782_1	760568.Desku_0371	6.71e-26	103.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,26123@186807|Peptococcaceae	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
k59_780782_2	289376.THEYE_A0626	1.05e-17	84.0	COG0465@1|root,COG0465@2|Bacteria,3J0AG@40117|Nitrospirae	40117|Nitrospirae	D	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_326168_1	1454004.AW11_00065	1.12e-84	266.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VIIH@28216|Betaproteobacteria	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_542253_1	458233.MCCL_1311	1.51e-10	67.0	COG4112@1|root,COG4112@2|Bacteria,1V277@1239|Firmicutes,4HGGN@91061|Bacilli,4GXK2@90964|Staphylococcaceae	91061|Bacilli	S	DNA mismatch repair protein MutT	ymaB	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_421519_1	1266925.JHVX01000004_gene1157	2.36e-66	215.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,3723M@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_542280_1	323848.Nmul_A1958	1.44e-80	249.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,37234@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_542280_2	1169143.KB911034_gene1636	3.11e-14	67.4	2BFH6@1|root,329AX@2|Bacteria,1QAV3@1224|Proteobacteria,2WDN8@28216|Betaproteobacteria,1KAN9@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_542280_3	1163617.SCD_n00856	4e-19	86.3	COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,2VJ0K@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the peptidase M17 family	-	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
k59_421533_1	1163409.UUA_15111	1.86e-13	75.1	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,1S04N@1236|Gammaproteobacteria,1X4W5@135614|Xanthomonadales	135614|Xanthomonadales	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
k59_796368_1	887062.HGR_09443	1.23e-32	124.0	COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,4ABW3@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_796368_2	1463881.KL591004_gene3781	5.05e-50	162.0	COG2164@1|root,COG2164@2|Bacteria,2II7B@201174|Actinobacteria	201174|Actinobacteria	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
k59_486138_1	765952.PUV_11340	7.98e-30	120.0	COG2204@1|root,COG2204@2|Bacteria,2JFQI@204428|Chlamydiae	204428|Chlamydiae	T	Sigma-54 dependent response regulator	atoC	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_421548_1	756272.Plabr_1285	2.39e-58	201.0	COG1520@1|root,COG1520@2|Bacteria,2IXCF@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
k59_326249_1	1121035.AUCH01000008_gene999	1.34e-73	236.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,2KUF7@206389|Rhodocyclales	206389|Rhodocyclales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_284238_1	96561.Dole_0706	4.96e-155	445.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_486142_1	1229909.NSED_09510	1.83e-43	150.0	COG1041@1|root,arCOG00047@2157|Archaea	2157|Archaea	L	RNA methylase	trmG10	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
k59_486142_2	1229909.NSED_09505	3.05e-50	167.0	COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Ribose-phosphate pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
k59_326252_1	330214.NIDE4185	6.69e-111	327.0	COG2853@1|root,COG2853@2|Bacteria	2|Bacteria	M	Lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_780886_1	1237149.C900_02026	3.11e-52	185.0	COG4631@1|root,COG4631@2|Bacteria,4PMEG@976|Bacteroidetes,47KPG@768503|Cytophagia	976|Bacteroidetes	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_486172_1	1123392.AQWL01000003_gene387	1.19e-69	217.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,1KS7Z@119069|Hydrogenophilales	119069|Hydrogenophilales	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_284263_1	945713.IALB_1623	8.75e-98	285.0	COG0377@1|root,COG0377@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_284263_2	945713.IALB_1624	2.08e-06	48.5	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_887950_2	1283300.ATXB01000001_gene1036	1.07e-30	114.0	COG0235@1|root,COG0235@2|Bacteria,1RE8T@1224|Proteobacteria,1S3UF@1236|Gammaproteobacteria,1XDKT@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)	mtnB	-	4.2.1.109	ko:K08964	ko00270,ko01100,map00270,map01100	M00034	R07392	RC01939	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
k59_627285_1	1229909.NSED_07525	6.36e-95	279.0	COG1491@1|root,arCOG04130@2157|Archaea,41SGD@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
k59_756538_1	1116472.MGMO_138c00290	1e-12	68.6	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RRZM@1236|Gammaproteobacteria,1XH02@135618|Methylococcales	135618|Methylococcales	C	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,SCO1-SenC
k59_756538_2	243233.MCA0317	1.99e-57	191.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,1S012@1236|Gammaproteobacteria,1XDJS@135618|Methylococcales	135618|Methylococcales	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_725467_1	765952.PUV_15350	1.07e-11	71.2	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria	2|Bacteria	O	protein N-acetylglucosaminyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Glycos_transf_2,SEC-C,Sulfotransfer_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
k59_497092_1	983917.RGE_42620	1.52e-121	357.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,1KJSN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_137799_1	765911.Thivi_3064	1.78e-50	179.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM Cytochrome c-type biogenesis protein CcmI	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
k59_921475_2	1304888.ATWF01000001_gene583	2.91e-80	251.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_7256_1	1008453.HMPREF9957_0151	4.05e-32	122.0	COG3335@1|root,COG3335@2|Bacteria,1VQBP@1239|Firmicutes,4HF3C@91061|Bacilli,2TQ1A@28037|Streptococcus mitis	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_725485_1	1348657.M622_08045	7.14e-74	229.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,2KUS0@206389|Rhodocyclales	206389|Rhodocyclales	M	UTP-glucose-1-phosphate uridylyltransferase	epsT	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_725485_2	29581.BW37_02558	1.77e-17	81.6	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,47338@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_953969_1	485913.Krac_1259	1.57e-59	197.0	COG3293@1|root,COG3293@2|Bacteria,2G9EK@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_39747_1	1144275.COCOR_01049	2.67e-79	251.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2YTTF@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_170423_2	436308.Nmar_0435	1.26e-40	135.0	COG2892@1|root,arCOG04414@2157|Archaea,41T5I@651137|Thaumarchaeota	651137|Thaumarchaeota	S	protein conserved in archaea	-	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
k59_431188_2	1304885.AUEY01000010_gene1648	4.36e-37	127.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2WR7Z@28221|Deltaproteobacteria,2MKM0@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_953976_1	1094508.Tsac_0169	4.56e-26	108.0	COG1609@1|root,COG1609@2|Bacteria,1UCPU@1239|Firmicutes,25BA2@186801|Clostridia,42JEG@68295|Thermoanaerobacterales	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_725493_1	690850.Desaf_2363	1.02e-76	238.0	28I6Z@1|root,2Z89U@2|Bacteria,1R8YM@1224|Proteobacteria	1224|Proteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_725493_2	1177154.Y5S_03557	0.000118	44.3	COG4333@1|root,COG4333@2|Bacteria,1N19M@1224|Proteobacteria,1SAS8@1236|Gammaproteobacteria,1XQS8@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1643
k59_397635_1	382245.ASA_0826	6.93e-35	139.0	COG2304@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,1Y5S8@135624|Aeromonadales	135624|Aeromonadales	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VWA
k59_562370_1	580332.Slit_2080	3.92e-70	224.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VJR5@28216|Betaproteobacteria,44V3R@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
k59_785828_1	1316927.ATKI01000031_gene5041	1.92e-08	60.5	COG2199@1|root,COG4963@1|root,COG3706@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,1S66J@1236|Gammaproteobacteria,1YNMU@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ
k59_693013_1	446462.Amir_5190	2.48e-59	196.0	COG3429@1|root,COG3429@2|Bacteria,2GJ1H@201174|Actinobacteria,4E0XZ@85010|Pseudonocardiales	201174|Actinobacteria	G	PFAM Glucose-6-phosphate dehydrogenase subunit	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
k59_39770_1	436308.Nmar_1774	4.21e-10	59.7	COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Ribose-phosphate pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
k59_39770_2	436308.Nmar_1773	1.56e-70	228.0	COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_1015208_1	497965.Cyan7822_1271	3.25e-103	313.0	COG2308@1|root,COG2308@2|Bacteria,1G0JF@1117|Cyanobacteria,3KHEA@43988|Cyanothece	1117|Cyanobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_823613_1	983917.RGE_08170	2.35e-144	414.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria,1KJ3J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_823613_2	420662.Mpe_A3112	2.43e-40	139.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,1KJKT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Fimbrial assembly	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_785830_1	1380394.JADL01000012_gene1057	3.2e-116	343.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TTTV@28211|Alphaproteobacteria,2JVMP@204441|Rhodospirillales	204441|Rhodospirillales	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_333553_1	1114970.PSF113_3470	6.36e-99	304.0	COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria,1YNTU@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	I	transferase	pcaI	-	2.8.3.5,2.8.3.6	ko:K01027,ko:K01028,ko:K01031	ko00072,ko00280,ko00362,ko00650,ko01100,ko01120,map00072,map00280,map00362,map00650,map01100,map01120	-	R00410,R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_725522_1	880073.Calab_2586	8.77e-43	152.0	COG0642@1|root,COG2205@2|Bacteria,2NS4W@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_888015_1	595460.RRSWK_01304	2.93e-78	258.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2IYB9@203682|Planctomycetes	203682|Planctomycetes	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
k59_39793_1	305700.B447_01326	1.47e-94	280.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,2KVKX@206389|Rhodocyclales	206389|Rhodocyclales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_39793_2	62928.azo1024	8.98e-46	152.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,2KVGG@206389|Rhodocyclales	206389|Rhodocyclales	S	synthesis repressor, PhaR	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
k59_397661_1	667014.Thein_1918	6.38e-37	137.0	COG0028@1|root,COG0028@2|Bacteria,2GHEM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_202953_1	1198452.Jab_2c24640	4.31e-74	228.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2VJ8E@28216|Betaproteobacteria,473K0@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
k59_202953_2	1131553.JIBI01000014_gene863	2.43e-27	105.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,371NN@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_1015225_1	1123502.AQXD01000003_gene1612	2.8e-08	57.4	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1X43I@135614|Xanthomonadales	135614|Xanthomonadales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_725534_1	1459636.NTE_01729	6.41e-22	91.7	COG1522@1|root,arCOG01585@2157|Archaea,41T4Z@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Archaeal TRASH domain	-	-	-	-	-	-	-	-	-	-	-	-	Arc_trans_TRASH,HTH_AsnC-type
k59_562415_1	264198.Reut_A3441	9.08e-117	366.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K25W@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_594864_1	83406.HDN1F_02990	1.71e-100	302.0	COG1960@1|root,COG1960@2|Bacteria,1R6EH@1224|Proteobacteria,1RMXW@1236|Gammaproteobacteria,1J5C0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_170485_1	671143.DAMO_0533	1.17e-86	283.0	COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_397670_1	1205680.CAKO01000037_gene1218	5.64e-75	236.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2JUZ6@204441|Rhodospirillales	204441|Rhodospirillales	V	Beta-lactamase	-	-	-	ko:K18372	ko00640,map00640	-	R10705	RC00460,RC00461	ko00000,ko00001,ko01000	-	-	-	Beta-lactamase
k59_660451_1	869213.JCM21142_42048	1.28e-57	182.0	COG1781@1|root,COG1781@2|Bacteria,4NR6N@976|Bacteroidetes	976|Bacteroidetes	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
k59_660451_2	385682.AFSL01000019_gene2278	4.88e-09	57.0	2E8SV@1|root,3333M@2|Bacteria,4NSHV@976|Bacteroidetes,2FV1F@200643|Bacteroidia,3XK4X@558415|Marinilabiliaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4293)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4293
k59_333580_2	314278.NB231_10959	7.31e-55	184.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_365986_1	1049564.TevJSym_ap00510	9.54e-79	254.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_365989_1	1219031.BBJR01000089_gene912	1.43e-107	334.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9PT@80864|Comamonadaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_986196_1	1357272.AVEO02000146_gene1436	7.14e-49	167.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1Z5WW@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	M	COG0501 Zn-dependent protease with chaperone function	Z012_09445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_7340_1	85643.Tmz1t_0789	4.61e-120	357.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,2KVM8@206389|Rhodocyclales	206389|Rhodocyclales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_333588_1	694440.JOMF01000004_gene1382	1.11e-50	174.0	COG0863@1|root,arCOG00890@2157|Archaea,2XWFW@28890|Euryarchaeota,2NBA0@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_823668_1	641147.HMPREF9021_00955	1.79e-33	133.0	COG0769@1|root,COG4823@1|root,COG0769@2|Bacteria,COG4823@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,2KQ1I@206351|Neisseriales	206351|Neisseriales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_855743_1	420662.Mpe_A3005	2.45e-12	65.9	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria,1KJNT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	dienelactone hydrolase	clcD	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_855743_2	864051.BurJ1DRAFT_4810	2.58e-35	132.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,1KJF7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	FP	PFAM Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_756610_1	1229909.NSED_09230	2.88e-70	216.0	COG5615@1|root,arCOG05392@2157|Archaea,41T4B@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
k59_954062_1	96561.Dole_2825	3.05e-84	270.0	COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria,2MIVJ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Fe-S cluster domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_627397_1	311403.Arad_8312	9.11e-09	62.8	COG1653@1|root,COG1653@2|Bacteria,1N98V@1224|Proteobacteria,2TSIS@28211|Alphaproteobacteria,4BAC4@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
k59_39835_1	640081.Dsui_2217	8.05e-82	270.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,2KVN8@206389|Rhodocyclales	206389|Rhodocyclales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_397693_2	1263831.F543_6380	2.14e-10	61.6	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1Y763@135625|Pasteurellales	135625|Pasteurellales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_562454_2	1131266.ARWQ01000004_gene1480	2.67e-12	68.9	COG0457@1|root,arCOG03038@2157|Archaea,41SMV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
k59_170526_1	311424.DhcVS_570	1.6e-21	97.1	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi,34CTK@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_431283_1	1090319.KE386571_gene2489	2.77e-09	58.5	COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,2UAVK@28211|Alphaproteobacteria,2K421@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
k59_39843_1	1123368.AUIS01000007_gene2819	4.37e-96	289.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,2NCEM@225057|Acidithiobacillales	1236|Gammaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_8385_2	1384056.N787_12560	3.25e-44	150.0	29W5V@1|root,30HQZ@2|Bacteria,1RFZX@1224|Proteobacteria,1S4QF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4184,YdjM
k59_432207_1	1122236.KB905142_gene537	1.29e-86	262.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VUZH@28216|Betaproteobacteria,2KKCA@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_203922_1	1095769.CAHF01000005_gene1469	2.42e-99	308.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria	28216|Betaproteobacteria	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_269365_1	1000565.METUNv1_03887	1.34e-181	520.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KUD5@206389|Rhodocyclales	206389|Rhodocyclales	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ
k59_726593_1	1454004.AW11_02609	7.48e-32	117.0	COG0454@1|root,COG0456@2|Bacteria,1RJDS@1224|Proteobacteria,2VSVF@28216|Betaproteobacteria	28216|Betaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_726593_2	1120999.JONM01000013_gene2128	4.37e-18	79.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria	28216|Betaproteobacteria	S	coa-binding	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
k59_208812_1	944435.AXAJ01000016_gene2533	7.94e-10	60.5	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2W6SC@28216|Betaproteobacteria,1KCHM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_208812_2	1116369.KB890024_gene4685	5.65e-24	97.1	COG3103@1|root,COG4991@2|Bacteria,1RBPM@1224|Proteobacteria,2U6WU@28211|Alphaproteobacteria,43JWX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1236,SH3_3
k59_402636_1	1380394.JADL01000001_gene2481	2.77e-94	290.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_371747_1	1159870.KB907784_gene1693	1.12e-64	207.0	COG0329@1|root,COG0329@2|Bacteria,1MWAH@1224|Proteobacteria,2VH30@28216|Betaproteobacteria	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_568490_1	472759.Nhal_1647	9.58e-72	221.0	COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,1T3Z1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
k59_503307_1	1266925.JHVX01000011_gene1510	3.76e-139	430.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,3727S@32003|Nitrosomonadales	28216|Betaproteobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_893713_1	1125863.JAFN01000001_gene1375	8.59e-16	76.3	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2WKBA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_600902_1	498761.HM1_0420	2.74e-20	97.1	COG0308@1|root,COG0308@2|Bacteria,1U6PC@1239|Firmicutes,24AYS@186801|Clostridia	186801|Clostridia	E	PFAM peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_371757_1	1384056.N787_07220	1.73e-20	86.3	COG3011@1|root,COG3011@2|Bacteria,1QDB3@1224|Proteobacteria,1T98W@1236|Gammaproteobacteria,1XBU9@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
k59_371757_2	1120999.JONM01000003_gene2723	1.22e-28	108.0	COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,2VQNT@28216|Betaproteobacteria,2KQ5T@206351|Neisseriales	206351|Neisseriales	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
k59_306085_1	330214.NIDE0811	1.34e-66	211.0	COG0685@1|root,COG0685@2|Bacteria,3J0I8@40117|Nitrospirae	40117|Nitrospirae	C	Methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
k59_306085_2	330214.NIDE0812	7.27e-61	194.0	COG0413@1|root,COG0413@2|Bacteria,3J0GX@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_402646_1	1218076.BAYB01000028_gene4736	1.67e-57	179.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2VSDQ@28216|Betaproteobacteria,1K7MU@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_437039_1	396588.Tgr7_2207	1.51e-170	488.0	COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria,1SKHD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
k59_437039_2	1163617.SCD_n00803	6.64e-83	254.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2VQNY@28216|Betaproteobacteria	28216|Betaproteobacteria	H	lipoate-protein ligase A	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_339556_1	1101190.ARWB01000001_gene1206	5.48e-16	76.3	COG2037@1|root,COG2037@2|Bacteria,1MVSD@1224|Proteobacteria,2TUWS@28211|Alphaproteobacteria,36ZDS@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Formylmethanofuran-tetrahydromethanopterin formyltransferase	ffsA	GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0030270,GO:0044237,GO:0044281	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
k59_339556_2	472759.Nhal_0014	1.28e-27	114.0	COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,1RZ5G@1236|Gammaproteobacteria,1X07F@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM Formylmethanofuran dehydrogenase, subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
k59_503315_1	1266925.JHVX01000006_gene2246	9.74e-54	175.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,2VRU5@28216|Betaproteobacteria,371XG@32003|Nitrosomonadales	28216|Betaproteobacteria	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_530750_1	933262.AXAM01000015_gene90	2.62e-73	234.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,2MHR4@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_893721_1	1321773.HMPREF9069_00219	9.85e-44	162.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4CUYP@84998|Coriobacteriia	84998|Coriobacteriia	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_239398_1	641149.HMPREF9016_01905	6.06e-68	228.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,2KPIP@206351|Neisseriales	206351|Neisseriales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_239398_2	519989.ECTPHS_04074	5.75e-05	45.4	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_787887_2	1122947.FR7_4439	4.89e-18	84.3	COG2855@1|root,COG2855@2|Bacteria,1UY2J@1239|Firmicutes,4H29J@909932|Negativicutes	909932|Negativicutes	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_273032_1	472759.Nhal_0412	2.29e-102	329.0	COG0247@1|root,COG0277@1|root,COG0437@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0437@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_633278_1	402626.Rpic_3912	1.42e-95	290.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VM67@28216|Betaproteobacteria,1K0ID@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	multicopper oxidase type 3	copA_2	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_530753_1	1120983.KB894578_gene3830	1.14e-66	212.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TTFX@28211|Alphaproteobacteria,1JPR6@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_371778_1	1235801.C822_00148	1.04e-13	71.2	2DZDP@1|root,32V80@2|Bacteria,1UPST@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_13564_1	1265502.KB905935_gene3107	1.96e-68	225.0	COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,4A9MR@80864|Comamonadaceae	28216|Betaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	arnT	-	-	-	-	-	-	-	-	-	-	-	-
k59_861548_2	1357714.A0A067XR00_9CAUD	1.35e-36	140.0	4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses  no RNA stage,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae	10662|Myoviridae	S	Pfam:DUF4815	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_143932_1	768671.ThimaDRAFT_4037	3.88e-103	313.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,1SDJ1@1236|Gammaproteobacteria,1X0RY@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_45868_2	96561.Dole_3053	1.03e-55	185.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MII7@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_78956_1	887062.HGR_08184	3.85e-19	85.9	COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2VKIK@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Dehydrogenase	garR	-	1.1.1.31,1.1.1.411	ko:K00020,ko:K08319	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_78956_2	994479.GL877879_gene5070	3.6e-17	81.6	COG2175@1|root,COG2175@2|Bacteria,2I9TE@201174|Actinobacteria,4ECWA@85010|Pseudonocardiales	201174|Actinobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_306130_1	1192034.CAP_0975	5.89e-54	179.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,42NRA@68525|delta/epsilon subdivisions,2WJ62@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
k59_761667_1	289376.THEYE_A1057	7.84e-62	197.0	COG4117@1|root,COG4117@2|Bacteria	2|Bacteria	C	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)	ydhU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03620,ko:K08354	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10149	RC02823	ko00000,ko00001,ko02000	5.A.3.5	-	-	Cytochrome_C7,Ni_hydr_CYTB
k59_273046_1	105559.Nwat_1476	2.44e-97	302.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1WWIM@135613|Chromatiales	135613|Chromatiales	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_273046_2	1122611.KB903996_gene7624	1.14e-32	129.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4EHQW@85012|Streptosporangiales	201174|Actinobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_568546_1	187272.Mlg_1870	3.02e-79	256.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales	135613|Chromatiales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_960329_1	123899.JPQP01000023_gene2790	1.84e-35	130.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,3T20J@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_960329_2	557598.LHK_00598	1e-85	264.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2VHJF@28216|Betaproteobacteria,2KPW1@206351|Neisseriales	206351|Neisseriales	H	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_111265_1	330214.NIDE0892	2.81e-50	164.0	29E6W@1|root,3014W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1018462_1	1267535.KB906767_gene758	1.25e-51	185.0	COG1530@1|root,COG1530@2|Bacteria,3Y40K@57723|Acidobacteria,2JHQU@204432|Acidobacteriia	204432|Acidobacteriia	J	PFAM RNA-binding protein AU-1 Ribonuclease E G	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
k59_208889_1	472175.EL18_02585	4.89e-64	207.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_78976_1	1123257.AUFV01000001_gene1475	3.91e-34	133.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1X38B@135614|Xanthomonadales	135614|Xanthomonadales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_467924_1	706587.Desti_5391	7.17e-47	160.0	293RH@1|root,2ZR74@2|Bacteria,1RGTJ@1224|Proteobacteria,42RWW@68525|delta/epsilon subdivisions,2WNTI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_761682_1	614083.AWQR01000055_gene1969	1.18e-12	71.6	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,4A9MA@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
k59_761682_2	767817.Desgi_2866	4.82e-38	136.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,2618D@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, ATPase component	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_111277_1	1123367.C666_01945	7.56e-92	280.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,2KUQV@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_111277_2	535289.Dtpsy_3310	1.28e-164	466.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,4AAB9@80864|Comamonadaceae	28216|Betaproteobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_467928_1	314278.NB231_16473	6.62e-06	47.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales	135613|Chromatiales	G	alpha amylase catalytic	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_467928_2	1123504.JQKD01000003_gene565	6.46e-73	229.0	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2WFQP@28216|Betaproteobacteria,4ABHJ@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM Conserved TM helix repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_633334_1	1150626.PHAMO_280235	2.28e-68	226.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales	204441|Rhodospirillales	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_568570_1	382464.ABSI01000010_gene3668	3.26e-87	274.0	COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia,2ITKY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
k59_45899_1	398578.Daci_4454	4.22e-14	74.7	COG3618@1|root,COG3618@2|Bacteria,1R5V9@1224|Proteobacteria,2VPT0@28216|Betaproteobacteria,4AH9T@80864|Comamonadaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_633338_1	1121335.Clst_0951	4.69e-80	250.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,3WIC7@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.2,1.4.1.3	ko:K00260,ko:K00261	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_601936_1	1097668.BYI23_A023910	5.87e-100	305.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,1K273@119060|Burkholderiaceae	28216|Betaproteobacteria	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_894712_1	1123277.KB893217_gene4688	1.34e-17	87.4	COG0438@1|root,COG0438@2|Bacteria,4NE0W@976|Bacteroidetes,47NIW@768503|Cytophagia	976|Bacteroidetes	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_700491_1	1123487.KB892835_gene3616	1.36e-98	301.0	COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2VJ01@28216|Betaproteobacteria,2KUP1@206389|Rhodocyclales	206389|Rhodocyclales	O	Alkyl hydroperoxide reductase	-	-	-	ko:K03387	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Thioredoxin_3
k59_438023_1	1232437.KL662001_gene4559	1.06e-83	259.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,42NEN@68525|delta/epsilon subdivisions,2WK9G@28221|Deltaproteobacteria,2MJRN@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_240297_1	1223410.KN050846_gene2045	3.59e-65	216.0	COG2957@1|root,COG2957@2|Bacteria,4NGF8@976|Bacteroidetes,1HYT2@117743|Flavobacteriia	976|Bacteroidetes	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
k59_79957_1	234267.Acid_3980	2.05e-74	232.0	COG3836@1|root,COG3836@2|Bacteria,3Y5ZN@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_177551_1	864051.BurJ1DRAFT_0878	2.85e-48	160.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VJXE@28216|Betaproteobacteria,1KM18@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_177551_2	1265502.KB905949_gene950	5.58e-34	125.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,4AAQZ@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_700496_1	1121035.AUCH01000016_gene2233	2.49e-67	229.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,2KVAE@206389|Rhodocyclales	206389|Rhodocyclales	NT	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
k59_46873_1	933262.AXAM01000017_gene3137	6.97e-81	267.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MHRJ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_307083_1	935261.JAGL01000006_gene2226	6.12e-25	102.0	COG3932@1|root,COG3932@2|Bacteria,1REE4@1224|Proteobacteria,2U7Z2@28211|Alphaproteobacteria,43JU8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Exopolysaccharide synthesis, ExoD	exoD	-	-	-	-	-	-	-	-	-	-	-	ExoD
k59_961389_1	396588.Tgr7_0300	1.05e-52	183.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales	135613|Chromatiales	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_862573_1	667632.KB890166_gene1456	3.94e-47	164.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VM8B@28216|Betaproteobacteria,1K4WK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_112321_1	1265313.HRUBRA_01073	4.79e-82	254.0	COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,1RNVG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
k59_1019000_1	1131451.O1K_00010	2.26e-88	266.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RP6D@1236|Gammaproteobacteria,1X5T7@135614|Xanthomonadales	135614|Xanthomonadales	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve_3
k59_1019000_2	1211114.ALIP01000060_gene792	8.11e-47	151.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,1S9EI@1236|Gammaproteobacteria,1X74K@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_307090_1	945713.IALB_0318	3.7e-55	188.0	COG0608@1|root,COG0608@2|Bacteria	2|Bacteria	L	single-stranded DNA 5'-3' exodeoxyribonuclease activity	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_307090_2	1192034.CAP_7460	2.42e-14	70.5	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2YUPW@29|Myxococcales	28221|Deltaproteobacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_993124_1	497964.CfE428DRAFT_5240	1.84e-85	260.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_372810_1	1047013.AQSP01000108_gene2058	1.68e-74	248.0	COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_438047_1	883080.HMPREF9697_02381	1.08e-12	67.4	COG0604@1|root,COG0604@2|Bacteria,1R2DZ@1224|Proteobacteria,2U2KW@28211|Alphaproteobacteria,3JWD1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_438047_2	196367.JNFG01000202_gene2511	2.7e-69	216.0	COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,2VR4M@28216|Betaproteobacteria,1K2UH@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,TehB
k59_596120_1	1121904.ARBP01000006_gene3681	2.22e-10	67.4	COG3419@1|root,COG4447@1|root,COG4932@1|root,COG5184@1|root,COG3419@2|Bacteria,COG4447@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,4NNEI@976|Bacteroidetes	976|Bacteroidetes	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF1566
k59_398715_2	1173028.ANKO01000065_gene5628	6.02e-24	99.4	COG2335@1|root,COG2335@2|Bacteria,1G6R4@1117|Cyanobacteria,1HBIV@1150|Oscillatoriales	1117|Cyanobacteria	M	Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
k59_106433_2	1192124.LIG30_1791	8.83e-45	154.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_9527_2	366394.Smed_1358	2.8e-17	82.8	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4BG5H@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_923739_1	326424.FRAAL0871	1.56e-16	83.6	COG3173@1|root,COG3173@2|Bacteria,2IEPN@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_433261_2	1234595.C725_2727	1.8e-44	157.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_758418_1	13035.Dacsa_3341	9.33e-38	130.0	COG3744@1|root,COG3744@2|Bacteria,1G6AR@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_758418_2	1173022.Cri9333_1186	1.7e-09	55.5	2DNUX@1|root,32ZA8@2|Bacteria,1G9XI@1117|Cyanobacteria,1HD9P@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_923741_1	706191.PANA_0256	1.15e-24	99.8	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,3VXXS@53335|Pantoea	1236|Gammaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_923741_2	1379698.RBG1_1C00001G0812	1.11e-51	170.0	COG0177@1|root,COG0177@2|Bacteria,2NPBI@2323|unclassified Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_302466_1	187272.Mlg_1298	2.7e-42	144.0	COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,1T2WV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_4
k59_528638_1	156889.Mmc1_2587	1.3e-50	173.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k59_825852_2	762984.HMPREF9445_02977	1.99e-34	130.0	COG2755@1|root,COG2755@2|Bacteria,4PP48@976|Bacteroidetes,2G12K@200643|Bacteroidia	976|Bacteroidetes	E	Pectic acid lyase	-	-	-	-	-	-	-	-	-	-	-	-	Pec_lyase
k59_923750_1	1487953.JMKF01000004_gene647	1.66e-17	76.3	COG0599@1|root,COG0599@2|Bacteria,1G8UR@1117|Cyanobacteria	1117|Cyanobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_41905_1	483219.LILAB_30160	5.43e-53	180.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,42QCN@68525|delta/epsilon subdivisions,2WIYT@28221|Deltaproteobacteria,2YV4K@29|Myxococcales	28221|Deltaproteobacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_368105_2	1191523.MROS_0286	2.17e-66	228.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug
k59_825856_2	1500893.JQNB01000001_gene632	3.24e-12	65.9	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,1RMS0@1236|Gammaproteobacteria,1X3U4@135614|Xanthomonadales	135614|Xanthomonadales	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_74893_1	1396141.BATP01000019_gene1718	5.97e-67	225.0	COG3225@1|root,COG3225@2|Bacteria,46UZA@74201|Verrucomicrobia,2IUBV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_857823_1	945713.IALB_2429	8.5e-21	92.8	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_956215_1	443255.SCLAV_5584	1.37e-44	157.0	COG0604@1|root,COG0604@2|Bacteria,2GK7Y@201174|Actinobacteria	201174|Actinobacteria	C	NADPH quinone	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_399482_1	96561.Dole_2812	1.77e-49	174.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N5C@68525|delta/epsilon subdivisions,2WM18@28221|Deltaproteobacteria,2MIV1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_499370_1	604331.AUHY01000013_gene2615	1.52e-09	58.2	COG1514@1|root,COG1514@2|Bacteria,1WJ1W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_499370_2	1123393.KB891329_gene1058	2.39e-72	221.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,1KRPQ@119069|Hydrogenophilales	119069|Hydrogenophilales	I	YgbB family	-	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_270470_1	666681.M301_1625	1.85e-47	174.0	COG4206@1|root,COG4206@2|Bacteria,1QUWU@1224|Proteobacteria,2WGQG@28216|Betaproteobacteria	28216|Betaproteobacteria	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_270473_1	479431.Namu_2536	1.48e-40	148.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
k59_107346_1	7668.SPU_019910-tr	2.37e-86	268.0	2CXRP@1|root,2RZ9M@2759|Eukaryota,3A84X@33154|Opisthokonta,3BTAV@33208|Metazoa,3DA4U@33213|Bilateria	33208|Metazoa	S	DDE superfamily endonuclease	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_38,HTH_Tnp_Tc3_1,HTH_Tnp_Tc3_2
k59_433296_1	987059.RBXJA2T_19256	6.29e-26	105.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KJEG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
k59_433296_2	859653.HIMB5_00004250	2.59e-51	167.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,4BQC2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	dapH	-	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_270475_1	357804.Ping_1785	9.55e-16	74.7	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,1S2JU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
k59_270475_2	1122222.AXWR01000004_gene1772	4.81e-31	115.0	2CVD4@1|root,32SXD@2|Bacteria,1WMZT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_140017_1	439375.Oant_3421	2.45e-50	177.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_41931_1	1163617.SCD_n02797	4.57e-15	73.6	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria	28216|Betaproteobacteria	H	synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_41931_2	323848.Nmul_A2688	6.85e-24	103.0	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,2VMG1@28216|Betaproteobacteria,372AA@32003|Nitrosomonadales	28216|Betaproteobacteria	H	HemX, putative uroporphyrinogen-III C-methyltransferase	hemX	-	2.1.1.107,4.2.1.75	ko:K02496,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,HemX
k59_988277_1	511995.CFPG_187	1.02e-63	211.0	COG2239@1|root,COG2239@2|Bacteria,4NGGN@976|Bacteroidetes,2FN1M@200643|Bacteroidia	976|Bacteroidetes	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_890008_1	1005048.CFU_1679	7.29e-31	120.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,472BS@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	NlpB/DapX lipoprotein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_890008_2	323848.Nmul_A1139	1.12e-56	184.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria,372ZG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_564582_1	1519464.HY22_13125	1.84e-17	81.6	COG0737@1|root,COG1520@1|root,COG0737@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	5_nucleotid_C,Cytochrome_C554,SBP_bac_8,SLH
k59_302514_1	76114.ebA1846	2.11e-61	205.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,2KWJY@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
k59_629540_1	358220.C380_10590	4.16e-46	161.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4AB79@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_74930_1	1191523.MROS_2388	2.53e-87	275.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_2_N,SASA
k59_399513_1	1121403.AUCV01000002_gene563	3.37e-120	373.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2WKEN@28221|Deltaproteobacteria,2MIWJ@213118|Desulfobacterales	28221|Deltaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_107368_1	979556.MTES_0958	2.32e-105	323.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4FM41@85023|Microbacteriaceae	201174|Actinobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_528658_1	323848.Nmul_A2383	1.48e-158	482.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,371N0@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_528658_2	399795.CtesDRAFT_PD1639	1.32e-26	104.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,4ABJQ@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	cbf2	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N_3
k59_464654_1	519989.ECTPHS_04990	3.55e-125	378.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_107369_1	765914.ThisiDRAFT_1981	3.82e-92	287.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_433320_2	264732.Moth_0422	2.26e-30	116.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,24E92@186801|Clostridia,42JBM@68295|Thermoanaerobacterales	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_9602_1	1100721.ALKO01000017_gene1733	3.05e-32	120.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,4AAEE@80864|Comamonadaceae	28216|Betaproteobacteria	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_9602_2	1500894.JQNN01000001_gene3488	3.72e-32	113.0	COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,474SM@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Belongs to the BolA IbaG family	yrbA	-	-	-	-	-	-	-	-	-	-	-	BolA
k59_629548_1	1453503.AU05_11255	5.14e-17	80.5	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,1RZ34@1236|Gammaproteobacteria,1YKH4@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	tauD	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_629548_2	1121116.KB894766_gene224	3.35e-11	63.2	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,2VKVU@28216|Betaproteobacteria,4AA8S@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_368158_1	330214.NIDE2718	6.76e-51	176.0	COG1538@1|root,COG1538@2|Bacteria,3J19C@40117|Nitrospirae	40117|Nitrospirae	MU	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_956263_2	400682.PAC_15707016	6.17e-15	78.6	COG0265@1|root,KOG1320@2759|Eukaryota,38G0B@33154|Opisthokonta,3BA39@33208|Metazoa	33208|Metazoa	O	pentacyclic triterpenoid metabolic process	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_433326_1	296591.Bpro_2750	1.56e-32	120.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VNFE@28216|Betaproteobacteria,4ABZE@80864|Comamonadaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_335757_1	95619.PM1_0202645	2.1e-62	205.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_662637_1	1347342.BN863_17220	1.3e-10	65.9	COG0501@1|root,COG0501@2|Bacteria,4NE0J@976|Bacteroidetes,1HZ8D@117743|Flavobacteriia	976|Bacteroidetes	O	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_988316_1	754476.Q7A_590	4.94e-40	134.0	COG1396@1|root,COG1396@2|Bacteria,1N3AQ@1224|Proteobacteria,1S8YT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
k59_335761_1	945713.IALB_0318	2.82e-112	340.0	COG0608@1|root,COG0608@2|Bacteria	2|Bacteria	L	single-stranded DNA 5'-3' exodeoxyribonuclease activity	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_528668_1	384765.SIAM614_19571	3.12e-64	209.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_172654_1	497964.CfE428DRAFT_0519	6.74e-81	253.0	COG0649@1|root,COG0649@2|Bacteria,46SA0@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_695396_1	1121127.JAFA01000002_gene1556	9.49e-73	234.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1KCHF@119060|Burkholderiaceae	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
k59_9630_1	675815.VOA_002831	6.69e-26	110.0	COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1XSWY@135623|Vibrionales	135623|Vibrionales	V	Na driven multidrug efflux pump	dinF	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_564629_1	2340.JV46_15520	2.87e-196	551.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,1RSIM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type alpha subunit	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_302554_1	1123070.KB899251_gene664	3.23e-18	84.3	COG1561@1|root,COG1561@2|Bacteria,46TP9@74201|Verrucomicrobia,2IU44@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_302554_2	292564.Cyagr_2295	0.000154	44.7	COG1219@1|root,COG1219@2|Bacteria,1G04H@1117|Cyanobacteria,22S96@167375|Cyanobium	1117|Cyanobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_662649_1	1101195.Meth11DRAFT_1869	5.6e-36	128.0	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,2VSIM@28216|Betaproteobacteria,2KKHC@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_825942_1	497321.C664_10617	5.35e-85	276.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
k59_923835_1	1123487.KB892835_gene3512	2.9e-35	125.0	COG3631@1|root,COG3631@2|Bacteria,1QXIX@1224|Proteobacteria,2WH4R@28216|Betaproteobacteria,2KZY7@206389|Rhodocyclales	206389|Rhodocyclales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
k59_205121_1	1190603.AJYD01000015_gene988	1.09e-09	62.8	COG1173@1|root,COG1173@2|Bacteria,1R5UW@1224|Proteobacteria,1S21I@1236|Gammaproteobacteria,1XWQQ@135623|Vibrionales	135623|Vibrionales	P	ABC-type dipeptide oligopeptide nickel transport systems, permease	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_205121_2	1380394.JADL01000016_gene414	1.01e-38	138.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRS8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	nikB	-	-	ko:K02033,ko:K15585	ko02010,ko02024,map02010,map02024	M00239,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_956295_2	1229909.NSED_09235	2.73e-25	99.4	arCOG03788@1|root,arCOG03788@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
k59_597086_1	1117958.PE143B_0106235	4.45e-36	129.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_597086_2	2340.JV46_15070	7.26e-48	160.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1J5AE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_695413_1	283699.D172_4157	2.28e-16	78.2	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,2Q4E4@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_825952_1	1366050.N234_10650	1.1e-31	123.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VM0F@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_825952_2	396595.TK90_0974	1.44e-17	78.6	2EJUZ@1|root,33DJM@2|Bacteria,1NIYD@1224|Proteobacteria,1SGV4@1236|Gammaproteobacteria,1WZJR@135613|Chromatiales	135613|Chromatiales	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
k59_149231_1	177437.HRM2_21540	1.79e-11	63.5	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,43BKT@68525|delta/epsilon subdivisions,2X6YX@28221|Deltaproteobacteria,2MJ3T@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K13892,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00348,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
k59_149231_2	932213.SPM24T3_18211	6.42e-37	139.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,402M2@613|Serratia	1236|Gammaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02031,ko:K02032,ko:K13892,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00348,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11,3.A.1.5.21,3.A.1.5.24	-	iSbBS512_1146.SbBS512_E2519	ABC_tran,oligo_HPY
k59_997279_1	1304866.K413DRAFT_4671	7.13e-10	59.3	COG1479@1|root,COG1479@2|Bacteria,1UT92@1239|Firmicutes,251YK@186801|Clostridia	186801|Clostridia	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF262
k59_766162_1	391616.OA238_c25880	2.37e-66	210.0	COG0834@1|root,COG0834@2|Bacteria,1N2RR@1224|Proteobacteria,2U0AF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_376904_1	338966.Ppro_2797	7.29e-65	206.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,43UVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	hdrF	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
k59_376904_2	1354722.JQLS01000004_gene4451	0.000408	43.1	COG0680@1|root,COG0680@2|Bacteria,1RICN@1224|Proteobacteria,2UA1I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	HycI
k59_965749_1	582744.Msip34_0475	7.41e-125	361.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,2KKS4@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_407178_2	436308.Nmar_0726	1.1e-76	244.0	COG0553@1|root,arCOG00883@2157|Archaea,41T0G@651137|Thaumarchaeota	651137|Thaumarchaeota	K	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_472253_1	330214.NIDE1301	4.08e-50	164.0	COG0081@1|root,COG0081@2|Bacteria,3J0GB@40117|Nitrospirae	40117|Nitrospirae	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_472253_2	330214.NIDE1302	1.81e-120	352.0	COG0222@1|root,COG0244@1|root,COG0222@2|Bacteria,COG0244@2|Bacteria,3J0NQ@40117|Nitrospirae	40117|Nitrospirae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_116586_1	378753.KRH_18580	7.1e-24	105.0	COG0560@1|root,COG3320@1|root,COG0560@2|Bacteria,COG3320@2|Bacteria,2GJVX@201174|Actinobacteria,1WCAU@1268|Micrococcaceae	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NAD_binding_4,Sterile
k59_116586_2	748247.AZKH_4302	1.61e-35	127.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2VGZ7@28216|Betaproteobacteria,2KUF1@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_898656_1	323850.Shew_3240	5.57e-45	153.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	response regulator	nodW	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_704894_2	1121335.Clst_2250	1.38e-19	89.4	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,3WJCP@541000|Ruminococcaceae	186801|Clostridia	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_376920_1	756272.Plabr_4716	2.99e-22	92.0	COG4270@1|root,COG4270@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,DoxX_2
k59_376920_2	1304872.JAGC01000009_gene170	2.21e-21	87.8	COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,43AYW@68525|delta/epsilon subdivisions,2X6D6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_965764_1	748247.AZKH_0271	3.23e-101	300.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,2KVKQ@206389|Rhodocyclales	206389|Rhodocyclales	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_310964_1	1212548.B381_13651	8.72e-90	278.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RVXM@1236|Gammaproteobacteria,1Z2EA@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_533278_1	1304885.AUEY01000003_gene545	4.58e-63	216.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_835431_1	1307436.PBF_20928	1.6e-20	97.1	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,4HAU7@91061|Bacilli,1ZB6A@1386|Bacillus	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_638515_2	1357275.AVEL02000151_gene1536	1.19e-56	198.0	COG0863@1|root,COG0863@2|Bacteria,1MY4G@1224|Proteobacteria,1RQHA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_573960_1	530564.Psta_1248	7.31e-80	262.0	COG0474@1|root,COG0474@2|Bacteria,2IXV7@203682|Planctomycetes	203682|Planctomycetes	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,SBP_bac_1
k59_181758_1	330214.NIDE0545	2.06e-30	125.0	COG0745@1|root,COG2202@1|root,COG3290@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3290@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GGDEF,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE,dCache_1
k59_638526_1	1000565.METUNv1_00709	1.93e-64	202.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VRCR@28216|Betaproteobacteria,2KW89@206389|Rhodocyclales	206389|Rhodocyclales	O	Bacterial protein of unknown function (DUF899)	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_638526_2	1218074.BAXZ01000003_gene645	7.27e-54	175.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2VQA2@28216|Betaproteobacteria,1JZN6@119060|Burkholderiaceae	28216|Betaproteobacteria	G	peptidyl-prolyl	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_243882_1	1075090.GOAMR_23_00100	4.64e-28	118.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4GCXD@85026|Gordoniaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	fadE	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_965784_1	637905.SVI_0004	1.16e-15	81.6	COG1622@1|root,COG2863@1|root,COG1622@2|Bacteria,COG2863@2|Bacteria,1MVYW@1224|Proteobacteria,1RY2R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
k59_533285_1	95619.PM1_0230245	7.13e-69	221.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K18219	-	M00667	-	-	ko00000,ko00002,ko03000	-	-	-	HTH_8,Sigma54_activat
k59_933200_1	748247.AZKH_0319	2.05e-116	348.0	COG3292@1|root,COG3292@2|Bacteria,1N0TN@1224|Proteobacteria,2VMZM@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop
k59_898684_1	314278.NB231_16458	3.88e-68	233.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales	135613|Chromatiales	G	PFAM glycoside hydrolase, family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_243885_1	1232410.KI421426_gene1372	3.66e-102	320.0	COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,42Q4Z@68525|delta/epsilon subdivisions,2WM28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase
k59_997347_1	1129368.SMIPMB4A_v3c4970	5.88e-08	57.4	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,3WUEB@544448|Tenericutes	544448|Tenericutes	L	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2,ResIII
k59_737359_2	1357423.S5MBW4_9CAUD	1.76e-31	124.0	4QAKE@10239|Viruses,4QUP7@35237|dsDNA viruses  no RNA stage	10239|Viruses	S	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_533287_1	269797.Mbar_A1660	6.19e-79	252.0	COG5476@1|root,arCOG09072@2157|Archaea,2XYJG@28890|Euryarchaeota	28890|Euryarchaeota	S	MlrC C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
k59_311004_1	748247.AZKH_p0194	4.86e-118	356.0	COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria,2KY1X@206389|Rhodocyclales	206389|Rhodocyclales	E	Peptidase M1 membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_606213_1	1163617.SCD_n02485	2.23e-58	194.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_472298_1	1151116.Q7S_03060	3.56e-15	80.1	COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1MU2P@1224|Proteobacteria,1RNF4@1236|Gammaproteobacteria,3FI7B@34037|Rahnella	1236|Gammaproteobacteria	G	phosphotransferase system, EIIB	ptsG_2	-	2.7.1.199,2.7.1.208	ko:K02790,ko:K02791,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02060,map00010,map00500,map00520,map02060	M00266,M00809	R02738,R04111	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.13,4.A.1.1.14,4.A.1.1.3,4.A.1.1.9	-	-	PTS_EIIB,PTS_EIIC
k59_84348_1	330214.NIDE4251	5.28e-49	166.0	COG1064@1|root,COG1064@2|Bacteria,3J0Y9@40117|Nitrospirae	40117|Nitrospirae	C	Zinc-binding dehydrogenase	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_898719_2	1123296.JQKE01000038_gene318	4.72e-57	195.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,2KPMW@206351|Neisseriales	206351|Neisseriales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_84360_2	330214.NIDE3971	5.29e-32	118.0	COG1187@1|root,COG1187@2|Bacteria,3J0RN@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.20,5.4.99.21,5.4.99.22	ko:K06178,ko:K06181,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_243919_1	953739.SVEN_3333	4.17e-49	176.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_898725_1	1565129.JSFF01000006_gene2554	6.83e-80	250.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQX@1236|Gammaproteobacteria,2QCYP@267890|Shewanellaceae	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_933237_2	243233.MCA2760	1.11e-23	100.0	COG1488@1|root,COG1488@2|Bacteria,1QJI0@1224|Proteobacteria,1THHZ@1236|Gammaproteobacteria,1XE4J@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
k59_214121_1	436308.Nmar_0395	1.18e-40	138.0	COG1730@1|root,arCOG01341@2157|Archaea,41SSP@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
k59_214121_2	1229909.NSED_01900	5.89e-135	383.0	COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_214121_3	436308.Nmar_0393	8.1e-31	120.0	COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Belongs to the peptidase S8 family	-	-	-	ko:K14647	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PA,Peptidase_S8
k59_898727_1	631362.Thi970DRAFT_03485	3.3e-46	166.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_181817_1	1173022.Cri9333_4084	2.16e-45	162.0	COG1653@1|root,COG1653@2|Bacteria,1G0AA@1117|Cyanobacteria,1H7SU@1150|Oscillatoriales	1117|Cyanobacteria	G	Carbohydrate ABC transporter substrate-binding protein, CUT1 family	ugpB	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
k59_116682_1	247490.KSU1_D0131	1.13e-35	135.0	COG4964@1|root,COG4964@2|Bacteria,2IYI6@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the GSP D family	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Secretin,T2SS-T3SS_pil_N
k59_533307_1	543728.Vapar_0468	2.48e-75	232.0	COG1280@1|root,COG1280@2|Bacteria,1MX0K@1224|Proteobacteria,2VR6Z@28216|Betaproteobacteria,4AFHZ@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_377002_1	1286106.MPL1_07443	1.06e-78	239.0	COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,1T0AA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer Membrane Lipoprotein	blc4	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
k59_835517_1	265072.Mfla_1109	1.3e-54	180.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KM5R@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_84381_1	767434.Fraau_2921	1.2e-93	290.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,1X33G@135614|Xanthomonadales	135614|Xanthomonadales	P	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0050311,GO:0055114	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_933258_1	614083.AWQR01000012_gene1344	3.81e-104	318.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VNGY@28216|Betaproteobacteria,4ADCT@80864|Comamonadaceae	28216|Betaproteobacteria	C	Phenol hydroxylase, C-terminal dimerisation domain	-	-	1.14.13.23,1.14.13.7	ko:K03380,ko:K19065	ko00362,ko00623,ko00624,ko00627,ko01120,ko01220,map00362,map00623,map00624,map00627,map01120,map01220	-	R00815,R01628,R03566	RC00046,RC00236	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Phe_hydrox_dim
k59_149361_1	1000565.METUNv1_01292	3e-85	274.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales	206389|Rhodocyclales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_407276_1	1158292.JPOE01000005_gene851	1.56e-20	92.4	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VJSW@28216|Betaproteobacteria,1KNG5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_407276_2	1348657.M622_12175	1.84e-05	45.4	COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,2KUZG@206389|Rhodocyclales	206389|Rhodocyclales	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
k59_835537_1	330214.NIDE0474	4.43e-101	301.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_672160_1	1071679.BG57_30885	1.97e-71	241.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria	28216|Betaproteobacteria	C	indolepyruvate ferredoxin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	POR,TPP_enzyme_C
k59_377035_1	264198.Reut_B4611	6.71e-20	89.4	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKDI@28216|Betaproteobacteria,1KC3M@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_606288_1	1430440.MGMSRv2_0172	2.14e-44	166.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,2JPPB@204441|Rhodospirillales	204441|Rhodospirillales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_933299_1	768671.ThimaDRAFT_2758	5.07e-55	172.0	COG0633@1|root,COG0633@2|Bacteria,1MZW3@1224|Proteobacteria,1SAM4@1236|Gammaproteobacteria,1WYJH@135613|Chromatiales	135613|Chromatiales	C	ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer2
k59_933299_2	1249627.D779_0996	2.15e-59	185.0	COG0633@1|root,COG0633@2|Bacteria,1N22M@1224|Proteobacteria,1S5ZW@1236|Gammaproteobacteria,1WY8H@135613|Chromatiales	135613|Chromatiales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer2
k59_737464_1	1123392.AQWL01000002_gene1978	6.53e-72	241.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KSKV@119069|Hydrogenophilales	119069|Hydrogenophilales	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_606302_1	519989.ECTPHS_03904	4.05e-22	90.9	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales	135613|Chromatiales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_606302_2	1112217.PPL19_16625	1.24e-31	116.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_275710_1	1229909.NSED_04525	2.59e-82	249.0	COG0785@1|root,arCOG02398@2157|Archaea,41SZE@651137|Thaumarchaeota	651137|Thaumarchaeota	O	cytochrome c biogenesis protein	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_407304_1	436308.Nmar_0085	2.93e-118	347.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_508798_1	1173024.KI912151_gene1639	1.14e-25	102.0	COG1309@1|root,COG1309@2|Bacteria,1G5IR@1117|Cyanobacteria,1JKA7@1189|Stigonemataceae	1117|Cyanobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_508798_2	1120792.JAFV01000001_gene867	8.72e-21	89.4	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2TRNJ@28211|Alphaproteobacteria,36ZPH@31993|Methylocystaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_606309_1	391625.PPSIR1_16130	9.2e-62	204.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_52263_2	1479237.JMLY01000001_gene3522	1.91e-13	67.0	COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,1S65C@1236|Gammaproteobacteria,467HZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG2166 SufE protein probably involved in Fe-S center assembly	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
k59_510017_1	1380393.JHVP01000005_gene3691	2.86e-67	220.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4ES69@85013|Frankiales	201174|Actinobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_510017_2	1206741.BAFX01000077_gene4115	1.09e-18	83.2	2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria,4FTY6@85025|Nocardiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_215351_1	926569.ANT_04910	2.05e-45	150.0	COG1765@1|root,COG1765@2|Bacteria,2G978@200795|Chloroflexi	200795|Chloroflexi	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
k59_907216_1	1280390.CBQR020000176_gene4680	8.36e-08	53.5	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,4H9ZM@91061|Bacilli,26S70@186822|Paenibacillaceae	91061|Bacilli	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	2.4.2.8,6.3.4.19	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01132,R01229,R02142,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_907216_2	1009370.ALO_14352	5.65e-28	111.0	COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,4H28J@909932|Negativicutes	909932|Negativicutes	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_319017_1	1123229.AUBC01000009_gene330	0.000493	43.9	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,3JRPF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tim44	MA20_24770	-	-	-	-	-	-	-	-	-	-	-	Tim44
k59_319017_2	766499.C357_02891	2.88e-12	65.1	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,2UF72@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein affecting phage T7 exclusion by the F plasmid	fxsA	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
k59_385238_1	1267534.KB906756_gene485	1.25e-17	84.7	COG0624@1|root,COG0624@2|Bacteria,3Y2UM@57723|Acidobacteria,2JKEA@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_93518_1	103733.JNYO01000008_gene5417	1.13e-53	194.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,2HEQP@201174|Actinobacteria,4DYQU@85010|Pseudonocardiales	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_93526_1	945713.IALB_0586	9.56e-57	197.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2
k59_93529_1	1459636.NTE_01608	3.09e-29	108.0	COG2406@1|root,arCOG01093@2157|Archaea,41S6X@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Ferritin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin
k59_942358_1	991905.SL003B_2628	1.04e-10	61.6	COG1073@1|root,COG1073@2|Bacteria,1RDAY@1224|Proteobacteria,2U5QZ@28211|Alphaproteobacteria,4BS61@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
k59_942358_2	330214.NIDE1922	5e-95	286.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_517862_1	760192.Halhy_3162	1.86e-23	106.0	COG3291@1|root,COG3291@2|Bacteria,4PKTY@976|Bacteroidetes	976|Bacteroidetes	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_125484_1	1232449.BAHV02000009_gene2418	8.49e-05	46.6	COG2746@1|root,COG2746@2|Bacteria,1V2QD@1239|Firmicutes,249QB@186801|Clostridia	186801|Clostridia	V	Aminoglycoside 3-N-acetyltransferase	yokD	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
k59_125484_2	671065.MetMK1DRAFT_00018210	2.32e-11	63.9	COG2020@1|root,arCOG03580@2157|Archaea	2157|Archaea	O	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
k59_158149_1	1121405.dsmv_2324	2.82e-45	166.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2MHUC@213118|Desulfobacterales	28221|Deltaproteobacteria	U	type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_746624_1	330214.NIDE2819	6.99e-78	246.0	COG0014@1|root,COG0014@2|Bacteria,3J0ET@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_251606_1	323848.Nmul_A1964	6.13e-55	183.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,372I8@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_907257_1	420662.Mpe_A2581	6.18e-97	298.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2VJ8P@28216|Betaproteobacteria,1KJ1B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	aorA	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_975106_2	751945.Theos_0428	2.67e-25	100.0	COG0204@1|root,COG0204@2|Bacteria,1WJEI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_414925_1	314292.VAS14_17816	7.04e-30	114.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,1S40A@1236|Gammaproteobacteria,1XWW8@135623|Vibrionales	135623|Vibrionales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
k59_714147_1	398767.Glov_1281	2.79e-18	89.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_1005974_1	1218074.BAXZ01000006_gene1565	7.17e-83	258.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJJQ@28216|Betaproteobacteria,1K237@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_27888_1	485915.Dret_1125	3.54e-30	123.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,4305Z@68525|delta/epsilon subdivisions,2WNZQ@28221|Deltaproteobacteria,2MH93@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase with PAS PAC sensor	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_4,PAS_9,Response_reg
k59_517889_2	237368.SCABRO_01247	3.82e-32	119.0	COG3335@1|root,COG3335@2|Bacteria,2J1BU@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_251618_1	189753.AXAS01000014_gene5691	5.41e-20	90.5	COG2084@1|root,COG2084@2|Bacteria,1MV27@1224|Proteobacteria,2TTCZ@28211|Alphaproteobacteria,3JT36@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
k59_93564_1	448385.sce8127	8.02e-63	213.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,42NVI@68525|delta/epsilon subdivisions,2WJTD@28221|Deltaproteobacteria,2YTYS@29|Myxococcales	28221|Deltaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_793569_1	502025.Hoch_4467	8.08e-61	206.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,42YQ0@68525|delta/epsilon subdivisions,2WTRV@28221|Deltaproteobacteria,2YUFX@29|Myxococcales	28221|Deltaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_353761_1	1131814.JAFO01000001_gene4928	1.8e-21	91.3	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria,3EZKG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_93568_1	706587.Desti_3260	2.46e-69	226.0	COG2203@1|root,COG2204@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	fhlA	-	-	ko:K02584,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,GAF_3,HTH_8,Response_reg,Sigma54_activat
k59_681434_1	1408442.JADE01000003_gene646	1.3e-06	50.8	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2YPDX@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	GatB Yqey family protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_681434_2	330214.NIDE1229	3.88e-93	278.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	3.1.3.3	ko:K03413,ko:K07315	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021	-	-	-	GGDEF,HATPase_c,HATPase_c_2,HisKA,Response_reg
k59_875717_1	748247.AZKH_0837	3.39e-37	135.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,2KUW4@206389|Rhodocyclales	206389|Rhodocyclales	P	MFS/sugar transport protein	narK	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_875717_2	640081.Dsui_1826	2.18e-33	117.0	COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,2VSP4@28216|Betaproteobacteria,2KX2K@206389|Rhodocyclales	206389|Rhodocyclales	P	Rieske-like [2Fe-2S] domain	-	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Rieske_2
k59_583293_2	713586.KB900536_gene2424	2.36e-23	95.1	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria,1X1WD@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_251635_1	909663.KI867150_gene2010	3.83e-52	178.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,2MRTS@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_319078_1	648757.Rvan_1714	1.15e-76	236.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,3N64F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
k59_537790_1	749927.AMED_5774	1.17e-30	124.0	COG3387@1|root,COG3387@2|Bacteria,2I774@201174|Actinobacteria,4EAE0@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C
k59_222748_1	743719.PaelaDRAFT_3543	3.35e-10	62.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,4HCQN@91061|Bacilli,26R1M@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_222748_2	671143.DAMO_2838	7.96e-22	97.1	COG4191@1|root,COG4191@2|Bacteria,2NQ9P@2323|unclassified Bacteria	2|Bacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_158209_1	1121937.AUHJ01000041_gene283	7.92e-74	233.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,1RN81@1236|Gammaproteobacteria,46AFS@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG0183 Acetyl-CoA acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
k59_517934_1	1121033.AUCF01000019_gene3705	4.38e-83	256.0	COG0535@1|root,COG0535@2|Bacteria,1N5G8@1224|Proteobacteria,2VB0H@28211|Alphaproteobacteria,2JVSF@204441|Rhodospirillales	204441|Rhodospirillales	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
k59_190289_1	1121405.dsmv_0483	1.32e-06	53.9	COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MHS7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_774218_2	1313172.YM304_05150	1.68e-43	152.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_975165_1	290397.Adeh_0829	5.03e-79	257.0	COG4412@1|root,COG4412@2|Bacteria,1P5IH@1224|Proteobacteria	1224|Proteobacteria	O	Peptidase M6, immune inhibitor A	ina	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M6
k59_280369_1	526222.Desal_0891	4.08e-94	280.0	COG0655@1|root,COG0655@2|Bacteria,1RAK6@1224|Proteobacteria,42QS5@68525|delta/epsilon subdivisions,2WN2M@28221|Deltaproteobacteria,2M7SB@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_774221_1	1163617.SCD_n00308	2.65e-52	183.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Lipid A Biosynthesis	htrB	-	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_774221_2	864051.BurJ1DRAFT_0624	0.000361	42.7	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,1KIUQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_746694_1	684719.HIMB114_00002020	4.48e-06	48.5	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,4BRDF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system permease	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_746694_2	1469245.JFBG01000052_gene2168	7.6e-126	363.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,1RQU2@1236|Gammaproteobacteria,1X2CD@135613|Chromatiales	135613|Chromatiales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_537796_1	522306.CAP2UW1_2844	2.76e-73	238.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family	rosB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_647444_1	580332.Slit_0110	1.72e-72	224.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,44VQQ@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_647444_2	395494.Galf_0159	8.74e-63	201.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,44VS1@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	Fimbrial assembly protein (PilN)	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_28760_2	1038859.AXAU01000010_gene1766	1.85e-07	51.2	COG3618@1|root,COG3618@2|Bacteria,1R4T9@1224|Proteobacteria,2TRFM@28211|Alphaproteobacteria,3JX2A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_28761_1	525146.Ddes_0901	1.9e-37	141.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2WJDZ@28221|Deltaproteobacteria,2M8IC@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	arginine decarboxylase	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_976043_1	316067.Geob_3164	9.61e-30	122.0	2AIHE@1|root,318Z9@2|Bacteria,1NWQ1@1224|Proteobacteria,42ZTQ@68525|delta/epsilon subdivisions,2WV9Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_943260_1	1229909.NSED_08825	3.26e-56	177.0	arCOG11425@1|root,arCOG11425@2157|Archaea,41T5C@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_943260_2	1229909.NSED_08830	8.93e-34	118.0	COG3432@1|root,arCOG01063@2157|Archaea,41T7S@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
k59_774980_1	1121448.DGI_1548	2.87e-24	99.8	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,42M12@68525|delta/epsilon subdivisions,2WIJX@28221|Deltaproteobacteria,2M7SU@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_774980_2	1397528.Q671_14960	2.74e-79	244.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1XS39@135619|Oceanospirillales	135619|Oceanospirillales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_354659_1	485915.Dret_0878	1.39e-62	213.0	COG3829@1|root,COG3850@1|root,COG4191@1|root,COG3829@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2M7VM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9
k59_319839_1	546271.Selsp_0584	6.45e-38	143.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,4H2GA@909932|Negativicutes	909932|Negativicutes	J	tRNA methylthiotransferase YqeV	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
k59_976045_1	756272.Plabr_2247	4.51e-99	307.0	COG1902@1|root,COG1902@2|Bacteria,2IXBM@203682|Planctomycetes	203682|Planctomycetes	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_451669_2	497964.CfE428DRAFT_2982	1.68e-56	184.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
k59_747547_1	330214.NIDE3554	3.59e-25	107.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	pcaD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_60415_1	192952.MM_3136	4.72e-63	202.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota,2N9R3@224756|Methanomicrobia	224756|Methanomicrobia	V	TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1006806_1	945713.IALB_2378	7.6e-47	161.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	pagO	-	-	ko:K07790	ko02020,map02020	-	-	-	ko00000,ko00001	2.A.7	-	-	EamA
k59_976057_1	349741.Amuc_0140	1.2e-67	219.0	COG0162@1|root,COG0162@2|Bacteria,46S76@74201|Verrucomicrobia,2IWM1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	tRNA synthetases class I (W and Y)	-	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
k59_1006809_1	566466.NOR53_398	1.06e-54	194.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,1J55S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
k59_682357_2	335543.Sfum_1126	5.83e-48	160.0	COG2050@1|root,COG2050@2|Bacteria,1PPMI@1224|Proteobacteria,437C5@68525|delta/epsilon subdivisions,2X383@28221|Deltaproteobacteria,2MSCH@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_126389_1	349161.Dred_0904	3.5e-32	115.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,262C4@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_715083_1	1266925.JHVX01000007_gene2283	1.6e-55	194.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,37233@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Signal transduction histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8
k59_682363_1	1229909.NSED_00345	3.72e-36	123.0	arCOG10516@1|root,arCOG10516@2157|Archaea,41T5R@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_682363_2	436308.Nmar_0093	6.47e-120	354.0	COG1817@1|root,arCOG01395@2157|Archaea,41S8D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
k59_806586_2	1125863.JAFN01000001_gene2544	9.12e-49	171.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_806630_1	261292.Nit79A3_2946	9.1e-68	219.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,371M5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.2.4,1.1.3.15,1.1.5.12	ko:K00102,ko:K00104,ko:K03777	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475,R00704,R11591	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_806630_2	1469245.JFBG01000015_gene1028	5.02e-12	66.6	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,1WX7V@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD linked oxidase domain protein	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1037420_2	1229909.NSED_05520	4.06e-31	117.0	COG0059@1|root,arCOG04465@2157|Archaea,41S65@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_806717_1	648757.Rvan_3198	7.47e-126	375.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,3N6I0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_806722_1	330214.NIDE0059	8.68e-93	279.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,3J1E4@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	Rhodanese,SNARE_assoc
k59_806734_1	1158318.ATXC01000001_gene335	1.46e-81	255.0	COG0216@1|root,COG0216@2|Bacteria,2G3PA@200783|Aquificae	200783|Aquificae	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_553561_1	426114.THI_2082	7.78e-76	248.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,1KJHP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	acsA	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C,PP-binding,Thioesterase
k59_806755_2	309798.COPRO5265_0181	1.8e-20	95.5	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,42FJV@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3
k59_1037482_1	1454004.AW11_01889	6.16e-66	212.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,1KPRG@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_553579_1	1121861.KB899912_gene1118	5.72e-79	255.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQSU@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Hydantoinase/oxoprolinase	-	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_806803_1	412597.AEPN01000003_gene3349	3.96e-11	61.6	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,2PWYD@265|Paracoccus	28211|Alphaproteobacteria	S	Yqey-like protein	MA20_04985	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_553641_1	1442599.JAAN01000005_gene957	4.56e-161	464.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1X37G@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Major facilitator superfamily	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_1037569_1	269482.Bcep1808_1786	6.36e-60	197.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,1K1S0@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	arnB	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_1037569_2	339670.Bamb_1798	4.64e-09	56.6	COG1215@1|root,COG1215@2|Bacteria,1QTWU@1224|Proteobacteria,2WGGD@28216|Betaproteobacteria,1K373@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Pfam Glycosyl transferase family 2	arnC	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
k59_553716_2	1283338.Q4Z8X8_BPTWO	1.39e-05	49.3	4QAPV@10239|Viruses,4QV7E@35237|dsDNA viruses  no RNA stage,4QQ0U@28883|Caudovirales,4QIXU@10662|Myoviridae	10662|Myoviridae	S	regulation of transcription, DNA-dependent	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1037584_1	1385420.FRA_44c11240	9.46e-18	87.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,1S076@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_806984_1	1297865.APJD01000003_gene6119	1.4e-06	51.2	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TRX5@28211|Alphaproteobacteria,3JRYA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	MA20_22930	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_806984_2	1415780.JPOG01000001_gene1823	2.75e-35	129.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1S4HN@1236|Gammaproteobacteria,1X9SZ@135614|Xanthomonadales	135614|Xanthomonadales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_553777_1	545276.KB898736_gene1269	3.47e-14	70.5	2DTBN@1|root,33JKH@2|Bacteria,1NNEI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28
k59_1037671_1	1121937.AUHJ01000003_gene3208	3.55e-46	154.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S9VR@1236|Gammaproteobacteria,4686G@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_553830_1	1209072.ALBT01000028_gene1290	1.3e-72	228.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides	gtrB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
k59_553842_2	1267533.KB906737_gene1703	2.97e-14	74.7	COG2986@1|root,COG2986@2|Bacteria,3Y3YW@57723|Acidobacteria,2JIK6@204432|Acidobacteriia	204432|Acidobacteriia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_553878_1	472759.Nhal_1189	2.81e-46	169.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_807140_1	1304883.KI912532_gene2267	8.47e-73	234.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,2VHXE@28216|Betaproteobacteria,2KYBF@206389|Rhodocyclales	206389|Rhodocyclales	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
k59_807171_1	945713.IALB_2372	4.75e-28	112.0	COG0248@1|root,COG0248@2|Bacteria	2|Bacteria	FP	Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
k59_1037802_1	85643.Tmz1t_3009	5.62e-14	72.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KVFI@206389|Rhodocyclales	206389|Rhodocyclales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1037827_1	1038859.AXAU01000030_gene6762	6.1e-88	273.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_554088_1	864069.MicloDRAFT_00000260	5.56e-97	291.0	COG3547@1|root,COG3547@2|Bacteria,1QPKD@1224|Proteobacteria,2TU1F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_554127_1	743720.Psefu_1691	4.85e-89	275.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1YWIC@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	udg	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_554143_1	742159.HMPREF0004_3416	9.06e-51	176.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_554178_1	716544.wcw_1881	1.57e-21	93.6	COG0296@1|root,COG0296@2|Bacteria,2JFFB@204428|Chlamydiae	204428|Chlamydiae	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_554178_2	1123393.KB891328_gene538	6.43e-45	154.0	COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2VKTC@28216|Betaproteobacteria,1KS56@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_554273_1	388413.ALPR1_11965	1.09e-163	480.0	COG3119@1|root,COG3119@2|Bacteria,4NEBN@976|Bacteroidetes,47TP1@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_554299_1	439375.Oant_0563	5.84e-10	59.7	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,1J2I1@118882|Brucellaceae	28211|Alphaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_554320_2	1219076.N646_4122	1.38e-41	149.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,1RN4R@1236|Gammaproteobacteria,1XSAW@135623|Vibrionales	135623|Vibrionales	C	Iron-sulfur cluster-binding domain	aslB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_807526_2	1163617.SCD_n01886	9.38e-105	305.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2VQC0@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
k59_807545_1	1278073.MYSTI_03819	4.01e-14	77.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	speE	GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
k59_554398_1	1163617.SCD_n01826	7.69e-197	554.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2VJ6C@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_554398_2	580332.Slit_1499	1.23e-09	59.3	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,44V4E@713636|Nitrosomonadales	28216|Betaproteobacteria	J	PFAM tRNA synthetase class II (D K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_554408_1	767817.Desgi_1980	2.32e-148	449.0	COG1148@1|root,COG1233@1|root,COG1148@2|Bacteria,COG1233@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia	1239|Firmicutes	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,Pyr_redox_2
k59_807567_1	305700.B447_19599	3.26e-67	222.0	COG4656@1|root,COG4656@2|Bacteria,1PJVF@1224|Proteobacteria,2VM4P@28216|Betaproteobacteria,2KUV4@206389|Rhodocyclales	206389|Rhodocyclales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_17,RnfC_N,SLBB
k59_807572_1	344747.PM8797T_06487	4.36e-39	137.0	COG2860@1|root,COG2860@2|Bacteria	2|Bacteria	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
k59_1038087_1	1459636.NTE_02685	8.18e-32	115.0	COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
k59_1038087_2	436308.Nmar_0053	1.75e-21	93.6	COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
k59_556554_1	926550.CLDAP_13150	5.92e-26	100.0	COG4290@1|root,COG4290@2|Bacteria,2G8WP@200795|Chloroflexi	200795|Chloroflexi	F	ribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuclease
k59_556554_2	264198.Reut_A2925	2.09e-09	58.5	2E7H0@1|root,331ZM@2|Bacteria,1NAWU@1224|Proteobacteria,2W5VE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Barstar (barnase inhibitor)	-	-	-	-	-	-	-	-	-	-	-	-	Barstar
k59_458358_1	926549.KI421517_gene2826	5.43e-38	139.0	COG3693@1|root,COG3693@2|Bacteria,4NE5Z@976|Bacteroidetes,47KU5@768503|Cytophagia	976|Bacteroidetes	G	PFAM Glycosyl hydrolase family 10	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_10
k59_458358_2	101852.XP_008077440.1	1.81e-24	100.0	COG5045@1|root,KOG3344@2759|Eukaryota,3A3IE@33154|Opisthokonta,3P3VQ@4751|Fungi,3QMD2@4890|Ascomycota,20W5B@147548|Leotiomycetes	4751|Fungi	J	Plectin/S10 domain	-	GO:0000028,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006403,GO:0006405,GO:0006407,GO:0006412,GO:0006518,GO:0006611,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0006996,GO:0008104,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015031,GO:0015833,GO:0015931,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031503,GO:0032991,GO:0033036,GO:0034613,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0042886,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0050657,GO:0050658,GO:0051029,GO:0051168,GO:0051169,GO:0051179,GO:0051234,GO:0051236,GO:0051641,GO:0051649,GO:0065003,GO:0070727,GO:0070925,GO:0071166,GO:0071426,GO:0071428,GO:0071702,GO:0071704,GO:0071705,GO:0071826,GO:0071840,GO:0097064,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02947	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S10_plectin
k59_654489_1	945713.IALB_1532	1.15e-85	270.0	COG3158@1|root,COG3158@2|Bacteria	2|Bacteria	P	potassium ion transmembrane transporter activity	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_197359_1	1123354.AUDR01000013_gene529	1.64e-19	87.0	COG2461@1|root,COG2461@2|Bacteria,1QWG2@1224|Proteobacteria,2WGYM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_327846_1	1000565.METUNv1_02256	4.48e-161	489.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales	206389|Rhodocyclales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_360387_2	682795.AciX8_2865	1.08e-14	74.7	COG0457@1|root,COG0515@1|root,COG1196@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG1196@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_132051_1	1121413.JMKT01000008_gene1287	1.34e-30	114.0	COG2204@1|root,COG2204@2|Bacteria,1MYUI@1224|Proteobacteria,42SHF@68525|delta/epsilon subdivisions,2WPJH@28221|Deltaproteobacteria,2MC5R@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_132051_2	644282.Deba_0058	6.99e-10	59.3	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42NQT@68525|delta/epsilon subdivisions,2WJKD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM sodium sulfate symporter	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_425751_1	1163617.SCD_n00147	3.01e-129	382.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2VHAC@28216|Betaproteobacteria	28216|Betaproteobacteria	E	COG0626 Cystathionine beta-lyases cystathionine gamma-synthases	metC	-	2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K01761	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
k59_491276_1	330214.NIDE4030	2.56e-42	154.0	COG5009@1|root,COG5009@2|Bacteria,3J0BH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding protein OB-like domain	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_491276_2	330214.NIDE4029	7.37e-39	130.0	COG2975@1|root,COG2975@2|Bacteria,3J1CR@40117|Nitrospirae	40117|Nitrospirae	S	Iron-sulphur cluster assembly	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
k59_491276_3	330214.NIDE4028	1.66e-13	69.7	COG0443@1|root,COG0443@2|Bacteria,3J0YD@40117|Nitrospirae	40117|Nitrospirae	O	Hsp70 protein	hscA	-	-	ko:K04043,ko:K04044	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33,1.A.33.1	-	-	HSP70
k59_66776_1	521674.Plim_2403	1.65e-106	334.0	COG0248@1|root,COG0248@2|Bacteria,2IYSV@203682|Planctomycetes	203682|Planctomycetes	FP	Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
k59_229846_1	1500894.JQNN01000001_gene4572	5.44e-46	168.0	COG0744@1|root,COG0744@2|Bacteria,1NRPB@1224|Proteobacteria,2VJ7F@28216|Betaproteobacteria,4768K@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_197371_1	794903.OPIT5_25515	2.5e-27	115.0	COG1640@1|root,COG1640@2|Bacteria,46SX0@74201|Verrucomicrobia,3K7CI@414999|Opitutae	414999|Opitutae	G	PFAM glycoside hydrolase family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_621791_1	322710.Avin_44180	1.06e-27	106.0	COG1226@1|root,32YV7@2|Bacteria,1N7MV@1224|Proteobacteria,1S4NR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1226 Kef-type K transport systems	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_719662_1	1192034.CAP_4369	1.31e-34	136.0	COG2723@1|root,COG3656@1|root,COG4733@1|root,COG4870@1|root,COG2723@2|Bacteria,COG3656@2|Bacteria,COG4733@2|Bacteria,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	2.7.11.1,3.2.1.4	ko:K01179,ko:K12567,ko:K20276,ko:K21000	ko00500,ko01100,ko02024,ko02025,ko05410,ko05414,map00500,map01100,map02024,map02025,map05410,map05414	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	GH39,GH5,GH9	-	CBM_6,DUF4347,He_PIG,Peptidase_C1,fn3
k59_360393_1	997346.HMPREF9374_1793	3.07e-33	129.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,4HBIM@91061|Bacilli,27BGM@186824|Thermoactinomycetaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	sugA_2	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_360393_2	484019.THA_846	2.66e-14	73.9	COG0395@1|root,COG0395@2|Bacteria,2GCIV@200918|Thermotogae	200918|Thermotogae	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_784107_1	330214.NIDE0841	9.26e-120	347.0	COG0074@1|root,COG0074@2|Bacteria,3J0WZ@40117|Nitrospirae	40117|Nitrospirae	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_621798_1	360094.PXO_04844	2.97e-80	249.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,1RY10@1236|Gammaproteobacteria,1X3VX@135614|Xanthomonadales	135614|Xanthomonadales	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_1395_1	264198.Reut_A2778	1.95e-08	54.7	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2VSE2@28216|Betaproteobacteria,1K3AH@119060|Burkholderiaceae	28216|Betaproteobacteria	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_1395_2	1502770.JQMG01000001_gene2273	5.64e-12	70.5	COG2218@1|root,COG2218@2|Bacteria,1MUUQ@1224|Proteobacteria,2VMB1@28216|Betaproteobacteria,2KKC9@206350|Nitrosomonadales	206350|Nitrosomonadales	C	PFAM glutamate synthase alpha subunit domain protein	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
k59_360402_1	1042163.BRLA_c009940	4.42e-38	140.0	COG0697@1|root,COG0697@2|Bacteria,1UZGC@1239|Firmicutes,4HDET@91061|Bacilli,26U8N@186822|Paenibacillaceae	91061|Bacilli	EG	EamA-like transporter family	yrdR	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_197388_1	880073.Calab_2860	7.36e-50	166.0	COG1428@1|root,COG1428@2|Bacteria,2NPEH@2323|unclassified Bacteria	2|Bacteria	F	Deoxynucleoside kinase	dgk	-	2.7.1.113	ko:K15518	ko00230,map00230	-	R01967	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HPPK,dNK
k59_458394_1	1510531.JQJJ01000014_gene4737	5.77e-82	258.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,3JT6J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_948203_1	1229909.NSED_08040	2.01e-194	559.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_663077_2	1298867.AUES01000009_gene6055	2.64e-10	63.9	COG0860@1|root,COG0860@2|Bacteria,1RJBG@1224|Proteobacteria,2TVMH@28211|Alphaproteobacteria,3JR6M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
k59_565094_1	243231.GSU1077	9.1e-88	267.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,43TWH@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_42443_1	234267.Acid_3332	4.12e-21	91.3	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_42443_2	492774.JQMB01000004_gene2225	1.02e-09	56.6	COG4274@1|root,COG4274@2|Bacteria,1N29P@1224|Proteobacteria,2UA3M@28211|Alphaproteobacteria,4BFGB@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
k59_728308_1	1206101.AZXC01000008_gene3041	1.79e-25	107.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_399933_2	883.DvMF_1364	2.48e-23	94.4	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42SII@68525|delta/epsilon subdivisions,2WPJG@28221|Deltaproteobacteria,2MGU2@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_10088_1	1187851.A33M_3527	3.02e-139	403.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2TRWV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_858328_1	861299.J421_0149	5.29e-13	68.2	COG0122@1|root,COG0122@2|Bacteria,1ZTST@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_302989_1	396588.Tgr7_0001	7.62e-127	374.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_956759_1	204669.Acid345_0821	9.56e-26	109.0	COG2202@1|root,COG4564@1|root,COG2202@2|Bacteria,COG4564@2|Bacteria	2|Bacteria	T	Single Cache domain 2	degS	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,PAS_3,sCache_2
k59_956759_2	1211777.BN77_p11113	3.89e-14	70.1	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2U895@28211|Alphaproteobacteria,4BAEM@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_465081_1	748280.NH8B_3145	2.47e-52	179.0	COG1459@1|root,COG1459@2|Bacteria,1N8FA@1224|Proteobacteria,2VJ0W@28216|Betaproteobacteria,2KSG9@206351|Neisseriales	206351|Neisseriales	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_695865_1	497321.C664_12505	3.23e-54	183.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,2KVHT@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_528946_1	1304883.KI912532_gene2564	1.33e-13	64.3	2CI9F@1|root,33H5J@2|Bacteria,1NH1E@1224|Proteobacteria,2VXVR@28216|Betaproteobacteria,2KXJZ@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_528946_2	1120983.KB894572_gene2924	2.37e-17	86.3	COG2271@1|root,COG2271@2|Bacteria,1R8Q1@1224|Proteobacteria,2U16E@28211|Alphaproteobacteria,1JQCK@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_303012_1	269799.Gmet_0663	3.08e-128	375.0	COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,42MMI@68525|delta/epsilon subdivisions,2WJZI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrogenase molybdenum-iron protein alpha chain	nifD	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
k59_663133_1	1167006.UWK_02979	1.04e-12	69.3	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MHWF@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
k59_433833_1	436308.Nmar_0700	1.16e-88	267.0	arCOG04054@1|root,arCOG04054@2157|Archaea,41SIQ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_399969_1	713586.KB900536_gene630	1.24e-103	309.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	ylbG	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_2,rve_3
k59_75495_1	1502770.JQMG01000001_gene874	1.69e-41	153.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,2KKGH@206350|Nitrosomonadales	206350|Nitrosomonadales	MU	TIGRFAM type I secretion outer membrane protein, TolC family	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_988795_1	414684.RC1_2673	9.97e-64	203.0	2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,2U7X0@28211|Alphaproteobacteria,2JSDR@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF2889)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2889
k59_663139_1	926561.KB900617_gene1679	3.82e-48	169.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,3WAD2@53433|Halanaerobiales	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_758937_1	330214.NIDE3889	1.42e-95	290.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3J0Q6@40117|Nitrospirae	2|Bacteria	C	Cytochrome b/b6/petB	qcrC	-	-	ko:K00412,ko:K03888	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B,Cytochrome_CBB3
k59_107911_1	1336208.JADY01000020_gene3415	4.81e-152	446.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TRHJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	MA20_44090	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_566561_1	1459636.NTE_02325	1.13e-29	110.0	COG0638@1|root,arCOG00970@2157|Archaea,41T1N@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
k59_566561_2	796620.VIBC2010_00710	2.98e-46	162.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1XT5K@135623|Vibrionales	135623|Vibrionales	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_174605_1	330214.NIDE3723	1.5e-120	358.0	COG1418@1|root,COG4372@1|root,COG1418@2|Bacteria,COG4372@2|Bacteria,3J0C8@40117|Nitrospirae	40117|Nitrospirae	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_174605_2	330214.NIDE3722	4.05e-122	353.0	COG1692@1|root,COG1692@2|Bacteria,3J0JW@40117|Nitrospirae	40117|Nitrospirae	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_76969_1	1205680.CAKO01000040_gene808	1.99e-65	207.0	2AY4N@1|root,31Q6J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_990204_1	688246.Premu_2153	1.01e-11	66.2	COG1028@1|root,COG1028@2|Bacteria,4NFTU@976|Bacteroidetes,2FQMI@200643|Bacteroidia	976|Bacteroidetes	IQ	Oxidoreductase, short chain dehydrogenase reductase family protein	fabG3	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_859738_1	1126627.BAWE01000005_gene5209	6.17e-54	177.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria,3JZQV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_337669_1	941449.dsx2_3086	1.39e-95	305.0	COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2M7Z1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	ABC transporter, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_174609_2	95619.PM1_0208895	1.04e-27	112.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_827915_1	335283.Neut_2310	6.89e-83	249.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,372W8@32003|Nitrosomonadales	28216|Betaproteobacteria	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
k59_664611_1	1255043.TVNIR_3111	1.3e-16	78.6	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_664611_2	95619.PM1_0203355	3.39e-35	125.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_109344_1	391615.ABSJ01000027_gene201	3.92e-68	220.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1J4TU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Domain of unknown function (DUF3333)	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_859742_2	1454004.AW11_02015	2.42e-97	323.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_958316_1	706587.Desti_5385	1.04e-58	202.0	COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481,ko:K07712,ko:K07713	ko02020,map02020	M00497,M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,PAS_4,Response_reg,Sigma54_activat
k59_566582_1	1469245.JFBG01000008_gene774	2.29e-17	82.8	COG2807@1|root,COG2807@2|Bacteria,1QW6Q@1224|Proteobacteria	1224|Proteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_566582_2	685035.ADAE01000020_gene1521	7.25e-21	93.6	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,2JZUZ@204457|Sphingomonadales	204457|Sphingomonadales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_109345_1	1366050.N234_20045	1.14e-210	594.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VJ87@28216|Betaproteobacteria,1K0QY@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	dctA	-	-	ko:K11103	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.23.1.3,2.A.23.1.6,2.A.23.1.7	-	-	SDF
k59_729829_1	1038858.AXBA01000001_gene3470	1.62e-58	194.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3EYSH@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	PFAM aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_729829_2	709797.CSIRO_2183	4.58e-05	45.8	COG3181@1|root,COG3181@2|Bacteria,1N7C4@1224|Proteobacteria,2TTPJ@28211|Alphaproteobacteria,3JVV2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	MA20_23135	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_304342_1	1454004.AW11_02264	1.12e-63	210.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2W02U@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_43933_1	1288494.EBAPG3_6210	2.84e-140	409.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VHQI@28216|Betaproteobacteria,372V1@32003|Nitrosomonadales	28216|Betaproteobacteria	E	peptidase M24B, X-Pro dipeptidase aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_859747_1	1357423.S5M7I0_9CAUD	6.27e-35	129.0	4QBP9@10239|Viruses,4QW69@35237|dsDNA viruses  no RNA stage,4QPQF@28883|Caudovirales	28883|Caudovirales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_760075_1	439235.Dalk_3266	3.09e-92	303.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_76997_1	7213.XP_004533164.1	2.24e-48	169.0	COG0481@1|root,KOG0462@2759|Eukaryota,38H35@33154|Opisthokonta,3B96N@33208|Metazoa,3CUGS@33213|Bilateria,41Y2A@6656|Arthropoda,3SH2T@50557|Insecta,44XBH@7147|Diptera	33208|Metazoa	J	Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner	-	-	-	-	-	-	-	-	-	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_787222_1	983917.RGE_02540	2.15e-96	305.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,1KJAA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_272073_1	1379698.RBG1_1C00001G0624	3.58e-90	274.0	COG0842@1|root,COG0842@2|Bacteria,2NPA6@2323|unclassified Bacteria	2|Bacteria	V	ABC-type multidrug transport system, permease component	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_760080_1	667632.KB890165_gene2485	5.97e-22	98.2	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1K035@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig
k59_77003_1	331113.SNE_A19550	2.69e-122	366.0	COG1274@1|root,COG1274@2|Bacteria,2JFEW@204428|Chlamydiae	204428|Chlamydiae	F	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_237861_1	1116472.MGMO_177c00220	1.68e-37	135.0	COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,1S48U@1236|Gammaproteobacteria,1XFI1@135618|Methylococcales	135618|Methylococcales	K	RNA polymerase sigma factor 70, region 4 type 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_370017_1	517418.Ctha_0472	5.81e-06	47.8	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1FEF9@1090|Chlorobi	1090|Chlorobi	C	electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO
k59_370017_2	1121430.JMLG01000002_gene1073	3.15e-50	170.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,260BA@186807|Peptococcaceae	186801|Clostridia	C	electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
k59_370019_1	1163617.SCD_n02433	6.53e-100	309.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VJDX@28216|Betaproteobacteria	28216|Betaproteobacteria	G	trehalohydrolase	treZ	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_337711_2	504487.JCM19302_3553	1.62e-27	109.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia	976|Bacteroidetes	Q	Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_599072_1	266264.Rmet_1184	1.13e-36	136.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKQJ@28216|Betaproteobacteria,1K5CT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_207018_1	436308.Nmar_1191	2.98e-79	255.0	COG1331@1|root,arCOG02007@2157|Archaea,41SHZ@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_109391_1	706587.Desti_1903	7.26e-66	213.0	COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,43C51@68525|delta/epsilon subdivisions,2X7FD@28221|Deltaproteobacteria,2MR8I@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_215799_1	640081.Dsui_3386	5.4e-22	92.8	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VSCC@28216|Betaproteobacteria,2KYUB@206389|Rhodocyclales	206389|Rhodocyclales	K	Flagellar regulatory protein FleQ	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_183473_1	911045.PSE_p0173	1.85e-12	71.6	COG0662@1|root,COG4977@1|root,COG0662@2|Bacteria,COG4977@2|Bacteria,1R8XV@1224|Proteobacteria,2U2RN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
k59_739210_1	1415779.JOMH01000001_gene2497	8.95e-87	266.0	COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,1X4V4@135614|Xanthomonadales	135614|Xanthomonadales	HJ	Sugar-transfer associated ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST
k59_20741_1	794903.OPIT5_22670	1.22e-16	85.5	COG0793@1|root,COG0793@2|Bacteria,46S88@74201|Verrucomicrobia,3K7AE@414999|Opitutae	414999|Opitutae	M	C-terminal domain of tail specific protease (DUF3340)	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
k59_935022_1	1220535.IMCC14465_02140	2.71e-74	236.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,4BPFW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_510498_1	886293.Sinac_7397	8.37e-60	199.0	COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_900386_1	96561.Dole_1719	7.59e-80	264.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_20744_1	313628.LNTAR_17183	0.00021	49.7	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_118441_1	1187851.A33M_2127	2.05e-45	159.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria,3FDQF@34008|Rhodovulum	28211|Alphaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_6,SBP_bac_8
k59_346651_1	481805.EcolC_3406	2.47e-122	357.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,3XQKZ@561|Escherichia	1236|Gammaproteobacteria	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_346651_2	1415779.JOMH01000001_gene805	8.56e-16	77.4	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_868702_1	522306.CAP2UW1_1276	4.28e-49	165.0	COG1280@1|root,COG1280@2|Bacteria,1N227@1224|Proteobacteria,2VSH7@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_900393_1	1163617.SCD_n00349	2.23e-94	296.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2VM8J@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
k59_999105_1	768710.DesyoDRAFT_1133	4.45e-14	77.4	COG4675@1|root,COG5301@1|root,COG4675@2|Bacteria,COG5301@2|Bacteria,1UUY8@1239|Firmicutes,24TGK@186801|Clostridia	186801|Clostridia	S	tail collar domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_935038_1	414684.RC1_4067	3.96e-104	321.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TUZI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_53694_2	1306174.JODP01000006_gene3519	6.6e-49	159.0	COG0346@1|root,COG0346@2|Bacteria,2IHX4@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_511593_1	880526.KE386488_gene1593	6.19e-08	58.9	2AA85@1|root,341ZI@2|Bacteria,4P3WS@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_379589_1	1305735.JAFT01000005_gene3879	1.75e-21	95.1	COG1694@1|root,COG1694@2|Bacteria,1Q2Q6@1224|Proteobacteria,2V9YK@28211|Alphaproteobacteria,2PFRC@252301|Oceanicola	28211|Alphaproteobacteria	S	Mazg nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_347669_1	717774.Marme_3416	1.97e-57	196.0	COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,1RMNA@1236|Gammaproteobacteria,1XIH3@135619|Oceanospirillales	135619|Oceanospirillales	EG	Belongs to the IlvD Edd family	edd	-	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_534670_1	521011.Mpal_1949	6.3e-57	189.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,2N9RY@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_534670_2	1123376.AUIU01000001_gene762	0.000162	46.2	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
k59_444970_1	428125.CLOLEP_01409	7.47e-57	192.0	COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,3WNF4@541000|Ruminococcaceae	186801|Clostridia	S	Phage Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
k59_184428_2	28258.KP05_02120	1.7e-20	92.4	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XH97@135619|Oceanospirillales	135619|Oceanospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_379602_1	323848.Nmul_A1010	3.45e-56	187.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,3723M@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_379602_2	998088.B565_0352	1.53e-29	119.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1Y460@135624|Aeromonadales	135624|Aeromonadales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_936141_1	290397.Adeh_4347	2.34e-13	65.9	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,2YW5U@29|Myxococcales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_936141_2	1123487.KB892857_gene2496	9.96e-59	194.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,2KUDB@206389|Rhodocyclales	206389|Rhodocyclales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_474722_1	398767.Glov_3392	2.81e-13	68.2	COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,43F1K@68525|delta/epsilon subdivisions,2X5T3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
k59_474722_2	478749.BRYFOR_08725	4.78e-09	58.9	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,24JCU@186801|Clostridia	186801|Clostridia	G	peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
k59_641388_1	575540.Isop_1317	6.66e-05	50.4	COG3386@1|root,COG3420@1|root,COG3386@2|Bacteria,COG3420@2|Bacteria,2J2MQ@203682|Planctomycetes	203682|Planctomycetes	P	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
k59_21819_1	1232410.KI421420_gene3156	1.04e-19	93.2	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_119512_1	402881.Plav_1782	1.56e-56	189.0	COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2TRWW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P-450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_152165_1	1485544.JQKP01000021_gene44	5.96e-114	360.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,44VNH@713636|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_277123_2	1042377.AFPJ01000007_gene1882	6.49e-25	101.0	COG0823@1|root,COG0823@2|Bacteria,1R8X1@1224|Proteobacteria,1RZDN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_901423_1	1459636.NTE_00579	3.02e-64	207.0	COG0663@1|root,arCOG01849@2157|Archaea	2157|Archaea	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	ko:K08698	-	-	-	-	ko00000	-	-	-	Hexapep
k59_936161_2	1265505.ATUG01000002_gene1562	2.21e-34	132.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2MIQM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_87313_1	420662.Mpe_A1155	5.18e-54	179.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2VHF1@28216|Betaproteobacteria,1KIUY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_838440_1	926569.ANT_20420	1.31e-86	283.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi	200795|Chloroflexi	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_675134_1	338966.Ppro_0709	5.5e-33	132.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,43TNJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase, HAMP	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_445001_1	330214.NIDE3392	2.33e-103	321.0	COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_511641_1	580332.Slit_1076	5.05e-89	288.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,44UZF@713636|Nitrosomonadales	28216|Betaproteobacteria	C	NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_379628_1	1173026.Glo7428_4408	3.22e-54	182.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_707912_1	177437.HRM2_23930	1.59e-61	206.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,2MHPG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,TPR_6
k59_409685_1	397945.Aave_0779	5.53e-82	257.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_347721_1	211165.AJLN01000100_gene4294	3.69e-16	80.9	COG0277@1|root,COG0277@2|Bacteria,1GAQ7@1117|Cyanobacteria,1JKFR@1189|Stigonemataceae	1117|Cyanobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_675153_1	187272.Mlg_2185	2.22e-20	91.3	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_675153_2	196627.cg2643	1.02e-06	55.1	COG3135@1|root,COG3135@2|Bacteria,2GNQX@201174|Actinobacteria,22KK4@1653|Corynebacteriaceae	201174|Actinobacteria	Q	protein involved in benzoate metabolism	benE	-	-	ko:K05782	-	-	-	-	ko00000,ko02000	2.A.46.1	-	-	BenE
k59_313600_1	765914.ThisiDRAFT_1575	3.34e-38	134.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales	135613|Chromatiales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_313600_2	314278.NB231_05005	2.63e-29	111.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1WWK4@135613|Chromatiales	135613|Chromatiales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_675154_1	111780.Sta7437_0465	2.76e-59	197.0	COG3385@1|root,COG3385@2|Bacteria,1G2YX@1117|Cyanobacteria,3VMCZ@52604|Pleurocapsales	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_838468_1	1379698.RBG1_1C00001G0608	3.32e-42	157.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_16,TPR_2,TPR_8,TolB_N
k59_216899_1	1000565.METUNv1_03636	2.29e-06	48.5	28P5Y@1|root,2ZC0T@2|Bacteria,1RBDV@1224|Proteobacteria,2VZTY@28216|Betaproteobacteria,2KYJ2@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_216899_2	640081.Dsui_0697	3.81e-38	143.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KW95@206389|Rhodocyclales	206389|Rhodocyclales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_675169_1	323848.Nmul_A0589	2.65e-89	270.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,372EZ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_534705_1	1500301.JQMF01000003_gene4232	4.44e-31	124.0	COG3566@1|root,COG3566@2|Bacteria,1REIQ@1224|Proteobacteria,2U9XH@28211|Alphaproteobacteria,4BCNB@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2213)	-	-	-	ko:K09960	-	-	-	-	ko00000	-	-	-	DUF2213
k59_53782_1	396588.Tgr7_1148	1.78e-69	220.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RPGU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_184492_1	159087.Daro_3362	6.38e-55	180.0	COG0861@1|root,COG0861@2|Bacteria,1MXSK@1224|Proteobacteria,2VHZ5@28216|Betaproteobacteria,2KW4M@206389|Rhodocyclales	206389|Rhodocyclales	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_379658_1	1005995.GTPT_2364	3.56e-11	59.7	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,4BV1J@82986|Tatumella	1236|Gammaproteobacteria	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016151,GO:0016829,GO:0016846,GO:0019243,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0051186,GO:0051596,GO:0061727,GO:0071704,GO:1901564,GO:1901575,GO:1901615	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_733,iECABU_c1320.ECABU_c19040,iECED1_1282.ECED1_1851,iECNA114_1301.ECNA114_1699,iECOK1_1307.ECOK1_1770,iECP_1309.ECP_1597,iECS88_1305.ECS88_1700,iECSF_1327.ECSF_1514,iLF82_1304.LF82_0861,iNRG857_1313.NRG857_08275,iUMN146_1321.UM146_08895,iUTI89_1310.UTI89_C1842,ic_1306.c2044	Glyoxalase
k59_379658_2	1454004.AW11_00429	3.71e-34	118.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,1KR20@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Rubredoxin	rubA	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
k59_379658_3	580332.Slit_0041	9.98e-135	387.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,44V55@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_119572_1	861299.J421_0783	1.54e-23	107.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_474778_1	987059.RBXJA2T_03141	5.33e-50	165.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VJN5@28216|Betaproteobacteria,1KJZ3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	drrA	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_474778_2	1454004.AW11_01672	0.000254	42.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2VREB@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM MaoC domain protein dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
k59_511690_1	279714.FuraDRAFT_0117	2.2e-05	51.6	COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,2VKDN@28216|Betaproteobacteria,2KPWZ@206351|Neisseriales	206351|Neisseriales	MU	Outer membrane efflux protein	-	-	-	ko:K12543	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17,3.A.1.109.4	-	-	OEP
k59_246437_1	1434325.AZQN01000014_gene1354	3.72e-39	149.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Amidase_2,Big_5,CBM60,CBM_5_12_2,DUF3494,Glyco_hydro_11,He_PIG,Malectin,PA14,PATR,VCBS
k59_534711_1	945713.IALB_2257	6.94e-28	106.0	COG3298@1|root,COG3298@2|Bacteria	2|Bacteria	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	wlaX	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
k59_534711_2	945713.IALB_2258	1.23e-47	155.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	fcbC	-	3.1.2.28	ko:K07107,ko:K12073	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000	-	-	-	4HBT,4HBT_2
k59_313633_1	472759.Nhal_3902	4.6e-109	319.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales	135613|Chromatiales	L	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_277160_1	335283.Neut_0926	1.02e-76	233.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2VQD9@28216|Betaproteobacteria,371SU@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_576979_1	768671.ThimaDRAFT_3135	1.82e-93	288.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWWZ@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N,SLBB
k59_968863_2	330214.NIDE0016	4.47e-34	120.0	COG2514@1|root,COG2514@2|Bacteria	2|Bacteria	S	catechol 2,3-dioxygenase activity	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_1009304_1	671143.DAMO_0582	1.15e-80	253.0	COG0612@1|root,COG0612@2|Bacteria,2NNW3@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_848488_1	95619.PM1_0213410	4.74e-11	63.2	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	nucleotidyltransferase DNA polymerase involved in DNA repair	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
k59_227335_1	1121405.dsmv_3736	3.41e-94	280.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_64248_1	880072.Desac_2367	6.72e-48	171.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria	1224|Proteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_358870_2	580332.Slit_2163	1.28e-22	96.7	COG4726@1|root,COG4726@2|Bacteria,1N7I4@1224|Proteobacteria,2VVZB@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	PilX_N
k59_358870_3	1095769.CAHF01000022_gene339	4.53e-29	114.0	COG4966@1|root,COG4966@2|Bacteria,1RC4Q@1224|Proteobacteria,2VS7N@28216|Betaproteobacteria,476YR@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type IV Pilus-assembly protein W	pilW	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
k59_455580_1	85643.Tmz1t_2938	1.75e-76	240.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2VIH0@28216|Betaproteobacteria,2KVJ0@206389|Rhodocyclales	206389|Rhodocyclales	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
k59_64251_1	265072.Mfla_0215	7.48e-48	171.0	COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,2VICU@28216|Betaproteobacteria,2KM2K@206350|Nitrosomonadales	206350|Nitrosomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_8
k59_227345_1	1122135.KB893137_gene1194	6.93e-88	265.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2TS8M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	-	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
k59_130449_2	568706.BN118_1125	3.3e-11	67.0	2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,2VWJH@28216|Betaproteobacteria,3T7XQ@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306
k59_880387_1	1229909.NSED_02140	5.57e-136	392.0	COG1052@1|root,arCOG01755@2157|Archaea,41T1D@651137|Thaumarchaeota	651137|Thaumarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_880387_2	436308.Nmar_0410	2e-11	59.7	arCOG08666@1|root,arCOG08666@2157|Archaea,41SVR@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1010557_1	391595.RLO149_c037000	6.58e-45	160.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_652073_1	395961.Cyan7425_3840	2.47e-57	189.0	COG4589@1|root,COG4589@2|Bacteria,1GCQF@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the CDS family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_390230_1	933262.AXAM01000017_gene3150	7.6e-139	403.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria,2MI15@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
k59_282961_2	994573.T472_0207560	2.53e-28	111.0	COG1237@1|root,COG1237@2|Bacteria,1UWI6@1239|Firmicutes,247K3@186801|Clostridia,36H5I@31979|Clostridiaceae	186801|Clostridia	S	hmm pf00753	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_619831_2	639282.DEFDS_P194	1.3e-09	60.5	COG0187@1|root,COG0187@2|Bacteria,2GF29@200930|Deferribacteres	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0008094,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0042623,GO:0061505,GO:0140097	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_227380_1	1348114.OM33_05480	5.57e-16	76.6	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,2Q0NU@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	O	HflC and HflK could regulate a protease	hflC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_227380_2	1286106.MPL1_04155	6.81e-15	68.9	COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,1SH40@1236|Gammaproteobacteria,461GH@72273|Thiotrichales	72273|Thiotrichales	S	Uncharacterized protein conserved in bacteria (DUF2065)	-	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
k59_227380_3	247634.GPB2148_2407	9.44e-20	87.8	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1J4S0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_778574_1	1173025.GEI7407_1402	2.62e-18	89.4	COG4191@1|root,COG4191@2|Bacteria,1G0DI@1117|Cyanobacteria,1H7WA@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase regulating C4-dicarboxylate transport system	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,dCache_1
k59_619846_1	1120956.JHZK01000006_gene720	1.67e-46	165.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,1JNQM@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Proton-conducting membrane transporter	nuoM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_880419_2	1504672.669784592	1.68e-71	222.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VJ4K@28216|Betaproteobacteria,4AGP2@80864|Comamonadaceae	28216|Betaproteobacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17,Fer4_8
k59_419344_1	309801.trd_A0452	2.15e-89	277.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,27YSW@189775|Thermomicrobia	189775|Thermomicrobia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_778578_1	1122947.FR7_1163	4.67e-18	84.7	COG0778@1|root,COG0778@2|Bacteria,1V2D6@1239|Firmicutes,4H46P@909932|Negativicutes	909932|Negativicutes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_390260_1	467661.RKLH11_1478	4.01e-61	206.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3ZG51@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	Q	transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_419348_1	1047013.AQSP01000100_gene588	4.04e-20	89.0	COG3949@1|root,COG3949@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_419348_2	717785.HYPMC_2845	2.81e-30	116.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2TSIP@28211|Alphaproteobacteria,3N6FZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_195121_2	1235802.C823_00855	1.62e-09	60.8	COG0787@1|root,COG1835@1|root,COG0787@2|Bacteria,COG1835@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,25VG9@186806|Eubacteriaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1,5.1.1.18	ko:K01775,ko:K18348	ko00473,ko01100,ko01502,ko02020,map00473,map01100,map01502,map02020	M00652	R00401	RC00285	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	-	-	-	Acyl_transf_3,Ala_racemase_C,Ala_racemase_N
k59_911917_1	196367.JNFG01000040_gene7977	6.3e-53	179.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2VMXT@28216|Betaproteobacteria,1K33I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	paraquat-inducible protein A	pqiA	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_880440_2	373994.Riv7116_5818	5.07e-42	153.0	COG1554@1|root,COG1554@2|Bacteria,1G0DN@1117|Cyanobacteria,1HIEI@1161|Nostocales	1117|Cyanobacteria	G	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_619879_1	323848.Nmul_A2542	1.44e-77	239.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,3724R@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_162979_1	76114.ebA2252	8.89e-93	302.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales	206389|Rhodocyclales	E	glutamate synthase	gls1	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_323592_1	945713.IALB_0003	1.94e-10	60.8	COG1195@1|root,COG1195@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	recF	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K03629,ko:K07459	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k59_323592_2	945713.IALB_0002	2.9e-87	268.0	COG0592@1|root,COG0592@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_390296_1	883080.HMPREF9697_02657	1.83e-47	160.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TUVG@28211|Alphaproteobacteria,3JTCJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_390296_2	1120983.KB894571_gene2617	2.18e-16	80.1	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TVCH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_358968_1	768706.Desor_2361	2.85e-79	261.0	COG0243@1|root,COG0243@2|Bacteria,1V09X@1239|Firmicutes,24BPK@186801|Clostridia,264AS@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.2.3	ko:K07812	-	-	-	-	ko00000,ko01000,ko02000	5.A.3.4	-	-	Molybdopterin,Molydop_binding
k59_619893_1	1210884.HG799465_gene11340	7.16e-56	183.0	COG1801@1|root,COG1801@2|Bacteria,2IYWM@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
k59_911940_1	62928.azo0918	3.12e-19	90.9	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,2KUUR@206389|Rhodocyclales	206389|Rhodocyclales	T	Signal transduction histidine kinase	dctS	-	2.7.13.3	ko:K11711	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
k59_911940_2	686340.Metal_2228	1.71e-23	95.9	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1XGBY@135618|Methylococcales	135618|Methylococcales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_880457_1	237368.SCABRO_00346	7e-27	114.0	COG2010@1|root,COG2010@2|Bacteria,2IYC2@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_163007_1	331869.BAL199_06624	1.71e-91	275.0	COG1173@1|root,COG1173@2|Bacteria,1PFAG@1224|Proteobacteria,2V8S7@28211|Alphaproteobacteria,4BS73@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_283001_1	1121035.AUCH01000001_gene1921	2.68e-41	150.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2VHA7@28216|Betaproteobacteria,2KUYZ@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_64376_1	1097668.BYI23_C008010	3.02e-56	187.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKWF@28216|Betaproteobacteria,1K5CD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_64376_2	443152.MDG893_15050	3.5e-18	83.6	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,1RR4Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Cyclodeaminase	ocd2	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	iJN746.PP_4431	OCD_Mu_crystall
k59_911954_1	985054.JQEZ01000002_gene3846	1.45e-67	220.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_323636_1	330214.NIDE0384	5.15e-91	273.0	COG1121@1|root,COG1121@2|Bacteria,3J15M@40117|Nitrospirae	40117|Nitrospirae	P	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09817,ko:K09820	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_880477_2	1131553.JIBI01000046_gene1600	8.07e-32	124.0	COG2855@1|root,COG2855@2|Bacteria	2|Bacteria	P	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_778637_1	1205680.CAKO01000010_gene3839	1.41e-60	196.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2TUAG@28211|Alphaproteobacteria,2JRY4@204441|Rhodospirillales	204441|Rhodospirillales	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_1010650_1	526222.Desal_0728	2.58e-37	135.0	COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,43DT5@68525|delta/epsilon subdivisions,2X2RT@28221|Deltaproteobacteria,2M7Z4@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
k59_419405_1	1082933.MEA186_29997	5.01e-89	273.0	COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_652174_1	1273707.L7TP33_9CAUD	2.82e-05	47.8	4QFZG@10239|Viruses,4R03J@35237|dsDNA viruses  no RNA stage,4QTRK@28883|Caudovirales,4QNP7@10744|Podoviridae	10744|Podoviridae	S	Pfam:Terminase_3C	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_652174_2	1120977.JHUX01000003_gene852	4.56e-25	101.0	2BVDA@1|root,32QTA@2|Bacteria,1MYBS@1224|Proteobacteria,1S7PK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DNA-packaging protein gp3	-	-	-	-	-	-	-	-	-	-	-	-	GP3_package
k59_227491_1	1121106.JQKB01000170_gene5398	1.54e-35	125.0	2DTBN@1|root,33JKH@2|Bacteria,1NBVZ@1224|Proteobacteria,2VFY2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_419413_1	331869.BAL199_03919	1.02e-104	309.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TTEV@28211|Alphaproteobacteria,4BRTE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	MA20_20685	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_484124_1	1027273.GZ77_11430	9.12e-15	72.0	COG0748@1|root,COG0748@2|Bacteria,1RFVC@1224|Proteobacteria,1S3AV@1236|Gammaproteobacteria,1XQ69@135619|Oceanospirillales	135619|Oceanospirillales	P	Heme iron utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2470,Putative_PNPOx,Pyrid_oxidase_2
k59_778652_1	1110502.TMO_2242	7.46e-47	166.0	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria,2JQ7C@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_256058_1	1449049.JONW01000006_gene3230	8.47e-35	130.0	COG3637@1|root,COG3637@2|Bacteria,1N7AR@1224|Proteobacteria	1224|Proteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	DUF481,OMP_b-brl
k59_323662_1	871585.BDGL_001385	5.89e-75	245.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,3NIEV@468|Moraxellaceae	1236|Gammaproteobacteria	C	2,4-dienoyl-coA reductase	fadH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008670,GO:0009056,GO:0009062,GO:0009987,GO:0010181,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0016628,GO:0019395,GO:0019752,GO:0030258,GO:0032553,GO:0032787,GO:0033542,GO:0033543,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_390363_1	1123393.KB891328_gene562	4.85e-35	131.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2VI6Z@28216|Betaproteobacteria,1KSZH@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_484131_1	694431.DESACE_01995	4.37e-06	48.1	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WRX9@28221|Deltaproteobacteria,2M70Q@213113|Desulfurellales	28221|Deltaproteobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_484131_2	316067.Geob_1885	2.02e-13	69.7	COG3245@1|root,COG3245@2|Bacteria,1RJCX@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
k59_163059_1	1000565.METUNv1_00184	7.07e-115	353.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2VJ68@28216|Betaproteobacteria,2KUAW@206389|Rhodocyclales	206389|Rhodocyclales	E	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
k59_323674_1	1219375.CM002139_gene438	8.05e-65	210.0	COG0332@1|root,COG0332@2|Bacteria,1P9I2@1224|Proteobacteria,1S3GP@1236|Gammaproteobacteria,1X388@135614|Xanthomonadales	135614|Xanthomonadales	I	synthase	-	-	-	ko:K22317	-	-	-	-	ko00000	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_130603_1	926566.Terro_1099	2.51e-25	107.0	COG4948@1|root,COG4948@2|Bacteria,3Y2SS@57723|Acidobacteria,2JMG2@204432|Acidobacteriia	204432|Acidobacteriia	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_1010685_1	1236976.JCM16418_3006	2.38e-30	118.0	COG1028@1|root,COG1028@2|Bacteria,1TPHT@1239|Firmicutes,4HE3F@91061|Bacilli,26SSI@186822|Paenibacillaceae	91061|Bacilli	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1028110_1	551789.ATVJ01000001_gene792	6.64e-48	170.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,43WGR@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_227528_1	1159870.KB907784_gene3274	1.08e-88	273.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,3T1VQ@506|Alcaligenaceae	28216|Betaproteobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_256079_1	1229909.NSED_00185	9.71e-48	162.0	COG0484@1|root,arCOG02846@2157|Archaea,41SCZ@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DnaJ central domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_256079_2	1229909.NSED_00195	2.18e-20	82.0	arCOG10416@1|root,arCOG10416@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_795456_1	391615.ABSJ01000037_gene942	1.97e-23	100.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1J52N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefC	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_795456_2	1121861.KB899918_gene3285	4.34e-09	56.2	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria,2JRBN@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_1028116_2	76114.ebB122	1.98e-12	64.7	2EDY7@1|root,337T3@2|Bacteria,1RKSZ@1224|Proteobacteria,2VTSJ@28216|Betaproteobacteria,2KWV4@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_323711_1	261292.Nit79A3_0158	7.45e-71	228.0	COG5433@1|root,COG5433@2|Bacteria,1MXI8@1224|Proteobacteria,2W66H@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_395494_1	1123368.AUIS01000020_gene1076	1.43e-44	167.0	COG2203@1|root,COG4251@1|root,COG2203@2|Bacteria,COG4251@2|Bacteria,1RGKE@1224|Proteobacteria,1T5R6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4
k59_4313_2	404380.Gbem_0575	1.56e-21	92.0	COG2259@1|root,COG2259@2|Bacteria,1NC5I@1224|Proteobacteria,42V27@68525|delta/epsilon subdivisions,2WS2G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Methylamine	-	-	-	-	-	-	-	-	-	-	-	-	MauE
k59_69779_1	1125973.JNLC01000018_gene2320	1.77e-37	140.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_69779_2	1304878.AUGD01000006_gene6602	1.24e-16	83.2	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TT5Y@28211|Alphaproteobacteria,3JT2E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	MA20_15115	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_951057_1	1378168.N510_00313	1.23e-09	59.7	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes	1239|Firmicutes	NT	Chemotaxis protein CheC, inhibitor of MCP methylation	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC,CheX
k59_624624_1	1096546.WYO_2429	1.03e-83	255.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,1JR7I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM ABC transporter	gltL	-	3.6.3.21	ko:K02028,ko:K10004	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	ABC_tran
k59_624624_2	172088.AUGA01000005_gene7905	1.16e-105	311.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TQZ7@28211|Alphaproteobacteria,3JQXV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	gltK	-	-	ko:K02029,ko:K10002	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	BPD_transp_1
k59_232286_1	414684.RC1_2752	4.34e-30	116.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U7R8@28211|Alphaproteobacteria,2JUQC@204441|Rhodospirillales	204441|Rhodospirillales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_232286_2	215803.DB30_0260	5.64e-90	286.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2WJDZ@28221|Deltaproteobacteria,2YTWQ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_690128_1	1175306.GWL_42610	0.000829	41.2	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,472HN@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_690128_2	1116472.MGMO_112c00090	4.88e-14	68.6	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1XFG1@135618|Methylococcales	135618|Methylococcales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
k59_460744_1	1259795.ARJK01000003_gene1145	1.22e-17	84.3	COG4122@1|root,COG4122@2|Bacteria,1UF4M@1239|Firmicutes,24B70@186801|Clostridia,42GF1@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM O-methyltransferase, family 3	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
k59_364040_2	713586.KB900536_gene2181	1.02e-36	133.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1WY2X@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
k59_103173_1	349521.HCH_05969	4.33e-70	233.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1XHZK@135619|Oceanospirillales	135619|Oceanospirillales	U	Type II and III secretion system protein	pilQ	-	-	ko:K02507,ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_396181_1	378806.STAUR_4227	5.77e-06	50.8	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Response_reg
k59_135891_1	580332.Slit_2416	5.56e-76	240.0	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria	28216|Betaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
k59_785197_1	1380390.JIAT01000010_gene4575	1.37e-29	119.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CSGP@84995|Rubrobacteria	84995|Rubrobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_429306_1	436308.Nmar_1755	1.96e-18	81.3	COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
k59_429306_2	436308.Nmar_1754	1.31e-42	152.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
k59_135892_2	932213.SPM24T3_13106	6.19e-09	59.7	2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria,1S5QS@1236|Gammaproteobacteria,40412@613|Serratia	1236|Gammaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA
k59_691009_1	572477.Alvin_1718	7.06e-71	223.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1WY7U@135613|Chromatiales	135613|Chromatiales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_658406_1	546267.NEIPOLOT_01196	3.77e-07	50.8	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,2KQ7M@206351|Neisseriales	206351|Neisseriales	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_658406_2	305700.B447_01531	1.63e-17	82.4	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria,2KWRT@206389|Rhodocyclales	206389|Rhodocyclales	L	Belongs to the DnaA family	-	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
k59_396188_1	945713.IALB_3192	1.52e-85	283.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13,2.1.1.245,2.1.1.258	ko:K00197,ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00680,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00357,M00377,M00422	R00946,R02289,R09096,R09365,R10219,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_70701_1	945713.IALB_0255	4.52e-55	174.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	hoxF	-	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_70701_2	945713.IALB_0256	4.3e-42	148.0	COG1894@1|root,COG1894@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	hoxF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_135898_2	522306.CAP2UW1_3297	3.7e-23	91.7	COG2076@1|root,COG2076@2|Bacteria,1RHUW@1224|Proteobacteria,2VSEI@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Small multidrug resistance	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
k59_984283_1	62928.azo0988	6.83e-58	196.0	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales	206389|Rhodocyclales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
k59_37880_1	1123487.KB892868_gene1207	9.86e-90	294.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales	206389|Rhodocyclales	E	glutamate synthase	gls1	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_560406_1	471854.Dfer_4672	0.000271	42.7	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,47K4A@768503|Cytophagia	976|Bacteroidetes	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_560406_2	1336243.JAEA01000003_gene2469	5.04e-80	251.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TU6U@28211|Alphaproteobacteria,1JZ5M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_984286_1	1144319.PMI16_01177	1.3e-47	173.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,472M0@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_592878_1	583345.Mmol_2007	4.42e-66	212.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,2KME5@206350|Nitrosomonadales	206350|Nitrosomonadales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_135905_2	159087.Daro_3911	1.91e-35	128.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,2KV15@206389|Rhodocyclales	206389|Rhodocyclales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_691023_1	261292.Nit79A3_1755	2.46e-142	420.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,3722A@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_919562_1	34007.IT40_08705	5.42e-96	295.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2PX1C@265|Paracoccus	28211|Alphaproteobacteria	C	FAD binding domain	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_755163_1	1000565.METUNv1_02869	4.03e-47	159.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria,2KVQ8@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_201032_1	358220.C380_21755	4.64e-82	255.0	COG0607@1|root,COG0607@2|Bacteria,1RKRX@1224|Proteobacteria,2VTV2@28216|Betaproteobacteria,4AF5T@80864|Comamonadaceae	28216|Betaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd,Rhodanese
k59_625485_1	525904.Tter_0729	4.22e-15	71.2	COG0096@1|root,COG0096@2|Bacteria,2NPMS@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_625485_2	1123405.AUMM01000026_gene2198	3.22e-08	53.1	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,4HBAX@91061|Bacilli,26NFV@186821|Sporolactobacillaceae	91061|Bacilli	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_103210_2	1128421.JAGA01000001_gene2088	3.45e-57	190.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2NPCW@2323|unclassified Bacteria	2|Bacteria	PQ	Multicopper oxidase	nirK	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1,Cytochrom_C,Cytochrome_CBB3
k59_755169_2	330214.NIDE0007	1.5e-84	252.0	COG0691@1|root,COG0691@2|Bacteria,3J0Q4@40117|Nitrospirae	40117|Nitrospirae	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_560431_1	1291050.JAGE01000001_gene142	0.000189	47.0	COG4733@1|root,COG4733@2|Bacteria,1VWP3@1239|Firmicutes,2523P@186801|Clostridia	186801|Clostridia	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_755173_1	1123508.JH636455_gene69	8.08e-41	149.0	COG3464@1|root,COG3464@2|Bacteria,2J2VZ@203682|Planctomycetes	203682|Planctomycetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_984321_1	1121106.JQKB01000241_gene1629	3.06e-69	229.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,2JQKZ@204441|Rhodospirillales	204441|Rhodospirillales	G	Glycosyl hydrolases family 15	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
k59_821652_1	272560.BPSL3158	2.9e-92	285.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,1K273@119060|Burkholderiaceae	28216|Betaproteobacteria	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_331669_1	1121004.ATVC01000006_gene1311	2.26e-89	273.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,2KQDB@206351|Neisseriales	206351|Neisseriales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_5301_1	1288494.EBAPG3_11930	1.41e-119	363.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,371US@32003|Nitrosomonadales	28216|Betaproteobacteria	L	HELICc2	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k59_135954_1	1297569.MESS2_1190030	1.81e-41	152.0	COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria,43MZD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Metallopeptidase family M24	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k59_919594_2	1123504.JQKD01000019_gene5468	1.03e-10	61.6	COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria	1224|Proteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	3.7.1.18	ko:K20765	-	-	-	-	ko00000,ko01000	-	-	-	ECH_1
k59_625509_1	765911.Thivi_3997	4.16e-07	52.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1WVZ5@135613|Chromatiales	135613|Chromatiales	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_625509_2	864051.BurJ1DRAFT_2642	4.42e-168	479.0	COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,1KJQD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
k59_298719_1	1163617.SCD_n01944	6.64e-14	77.4	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria	28216|Betaproteobacteria	C	CoA-binding domain protein	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_168539_1	314285.KT71_07299	6.6e-42	150.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_266447_1	1121022.ABENE_12395	1.28e-41	149.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria,2KHRA@204458|Caulobacterales	204458|Caulobacterales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_70757_1	255470.cbdbA1601	3.97e-31	127.0	COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,34DMA@301297|Dehalococcoidia	301297|Dehalococcoidia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_658470_1	1110697.NCAST_37_01700	9.31e-57	186.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4FU5R@85025|Nocardiaceae	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA8	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_461432_1	1123024.AUII01000001_gene2731	5.99e-65	208.0	COG2513@1|root,COG2513@2|Bacteria,2GJZZ@201174|Actinobacteria,4E0PY@85010|Pseudonocardiales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	4.1.3.32	ko:K20454	ko00760,ko01120,map00760,map01120	-	R01355	RC00286,RC01810	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_691068_2	2340.JV46_06030	1.04e-22	99.8	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J8GC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
k59_691068_3	1085623.GNIT_1543	4.91e-25	107.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,464XK@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	EAL,GGDEF,PAS,PAS_3,PAS_9,Reg_prop
k59_625512_1	1459636.NTE_03043	1.82e-62	202.0	COG1899@1|root,arCOG04142@2157|Archaea,41SWS@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
k59_266449_1	1500301.JQMF01000008_gene982	5.61e-42	146.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,4BAX2@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_37938_1	1121920.AUAU01000009_gene1914	1.47e-91	279.0	COG1251@1|root,COG1251@2|Bacteria	2|Bacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	narC	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_592934_1	522306.CAP2UW1_4217	1.67e-92	280.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,1KPPJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_495284_1	96561.Dole_0567	2.12e-24	106.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2MI1W@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
k59_70769_1	1454004.AW11_03522	1.23e-64	224.0	COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2VIUH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	membrane-associated Zn-dependent proteases 1	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	PqqD
k59_723595_1	1123255.JHYS01000018_gene105	1.34e-09	59.3	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,4AA3P@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	mmaA3	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_723595_2	1123393.KB891327_gene353	3.64e-46	155.0	2B1HQ@1|root,31TYQ@2|Bacteria,1MYSE@1224|Proteobacteria,2VTMU@28216|Betaproteobacteria,1KSAH@119069|Hydrogenophilales	119069|Hydrogenophilales	S	CNP1-like family	-	-	-	-	-	-	-	-	-	-	-	-	CNP1
k59_723595_3	1123393.KB891327_gene354	3.94e-174	496.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,1KRB9@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_560458_5	445686.E3SL64_9CAUD	1.82e-61	199.0	4QAWI@10239|Viruses,4QW40@35237|dsDNA viruses  no RNA stage,4QPUX@28883|Caudovirales,4QINW@10662|Myoviridae	10662|Myoviridae	S	Pfam:Peptidase_S77	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_658487_1	522306.CAP2UW1_2511	2.11e-95	290.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria	28216|Betaproteobacteria	C	pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_233039_1	323848.Nmul_A2731	1.06e-93	305.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,3727S@32003|Nitrosomonadales	28216|Betaproteobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_37960_1	936455.KI421499_gene608	2.7e-61	199.0	COG3181@1|root,COG3181@2|Bacteria,1MW18@1224|Proteobacteria,2U2TB@28211|Alphaproteobacteria,3JT1W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_984366_1	1324957.K933_16497	4.78e-23	105.0	COG3119@1|root,arCOG02785@2157|Archaea,2XV54@28890|Euryarchaeota,23UWR@183963|Halobacteria	183963|Halobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_886263_1	323848.Nmul_A1361	2.47e-161	471.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,371QU@32003|Nitrosomonadales	28216|Betaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_461462_1	1038869.AXAN01000051_gene5561	4.21e-118	360.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2VIGM@28216|Betaproteobacteria,1K1A2@119060|Burkholderiaceae	28216|Betaproteobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_373683_2	316067.Geob_1539	1.56e-58	186.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42RR2@68525|delta/epsilon subdivisions,2WNPQ@28221|Deltaproteobacteria,43TIT@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1269	Aconitase_C
k59_469438_1	1123487.KB892844_gene854	9.57e-71	233.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,2KUGX@206389|Rhodocyclales	206389|Rhodocyclales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_404265_1	1288494.EBAPG3_20400	1.19e-147	429.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2VI1D@28216|Betaproteobacteria,371MX@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	rsmB_2	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
k59_404265_2	228410.NE1467	1.48e-131	383.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,37215@32003|Nitrosomonadales	28216|Betaproteobacteria	I	fatty acid desaturase	ole1	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_962359_1	1120999.JONM01000006_gene2416	3.69e-81	244.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,2KQ6A@206351|Neisseriales	206351|Neisseriales	E	Psort location Cytoplasmic, score 8.96	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
k59_962359_2	580332.Slit_2404	5.42e-33	126.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,44V6P@713636|Nitrosomonadales	28216|Betaproteobacteria	H	PFAM thiamine pyrophosphate	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_895640_1	391593.RCCS2_17181	1.91e-105	323.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,2P1D2@2433|Roseobacter	28211|Alphaproteobacteria	H	Belongs to the transketolase family	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_307926_1	930166.CD58_24965	3.86e-69	228.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_863512_1	335543.Sfum_1549	3.55e-68	232.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MR0B@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_241035_1	1121405.dsmv_0034	1.23e-38	145.0	COG1466@1|root,COG1466@2|Bacteria,1RAEB@1224|Proteobacteria,42R0X@68525|delta/epsilon subdivisions,2WMQJ@28221|Deltaproteobacteria,2MJNX@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III, delta'	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
k59_788624_1	1260356.D920_02955	7.46e-21	97.4	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,4HAEZ@91061|Bacilli,4B0BX@81852|Enterococcaceae	91061|Bacilli	S	7TM-HD extracellular	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_274057_1	234267.Acid_0431	2.22e-26	111.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
k59_404273_1	177437.HRM2_15120	8.68e-60	191.0	COG2010@1|root,COG2010@2|Bacteria,1P88Q@1224|Proteobacteria,43BRV@68525|delta/epsilon subdivisions,2X73R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrome_C7
k59_929794_1	102107.XP_008245012.1	5.12e-57	192.0	COG0547@1|root,KOG1438@2759|Eukaryota,37KW6@33090|Viridiplantae,3GDTU@35493|Streptophyta,4JK8E@91835|fabids	35493|Streptophyta	E	Anthranilate phosphoribosyltransferase	-	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0031967,GO:0031975,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_701506_1	1454004.AW11_01727	1.59e-44	150.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VR39@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_962371_1	399795.CtesDRAFT_PD3802	2.97e-38	143.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VJTU@28216|Betaproteobacteria,4AAYT@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_602885_1	404380.Gbem_0905	1.14e-25	114.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,Response_reg
k59_832032_1	1219035.NT2_09_00380	3.42e-12	73.6	COG4774@1|root,COG4774@2|Bacteria	1219035.NT2_09_00380|-	P	siderophore transport	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_145936_1	1163617.SCD_n01837	7.59e-21	84.3	COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,2VXV9@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Heavy metal-associated domain protein	copZ	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
k59_145936_2	323848.Nmul_A2278	1.51e-38	130.0	COG1937@1|root,COG1937@2|Bacteria,1N9P2@1224|Proteobacteria,2VUK5@28216|Betaproteobacteria,373DZ@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
k59_439016_1	986075.CathTA2_0069	3.86e-157	455.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli	91061|Bacilli	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_47801_2	398767.Glov_2457	2.04e-110	337.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	epsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_962379_1	177437.HRM2_39300	9.43e-68	226.0	COG1032@1|root,COG1032@2|Bacteria,1NAY8@1224|Proteobacteria,42TR8@68525|delta/epsilon subdivisions,2WQC1@28221|Deltaproteobacteria,2MMMU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_469458_1	1380394.JADL01000001_gene2249	3.05e-11	62.4	COG0637@1|root,COG0637@2|Bacteria,1MX6B@1224|Proteobacteria,2TTVS@28211|Alphaproteobacteria,2JSAF@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the HAD-like hydrolase superfamily. PhnX family	phnX	-	3.11.1.1	ko:K05306	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R00747	RC00368	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_469458_2	1536774.H70357_07670	1.34e-60	201.0	COG0160@1|root,COG0160@2|Bacteria,1UMS0@1239|Firmicutes,4HEJW@91061|Bacilli,26U21@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_788628_1	335659.S23_14870	8.25e-27	113.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JXHE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_602895_1	1229909.NSED_08340	9.72e-32	123.0	COG0031@1|root,COG0607@1|root,arCOG01430@2157|Archaea,arCOG02021@2157|Archaea,41SYY@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_602895_2	1229909.NSED_02115	6.96e-33	124.0	COG1503@1|root,arCOG01742@2157|Archaea	1229909.NSED_02115|-	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	-	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	-
k59_733915_1	293826.Amet_4279	1.41e-55	185.0	COG1266@1|root,COG1266@2|Bacteria,1V1I8@1239|Firmicutes,24EXX@186801|Clostridia,36IEW@31979|Clostridiaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_404286_1	292415.Tbd_1174	2.39e-164	512.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_145952_1	1380394.JADL01000005_gene5674	4.01e-62	199.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2TS1B@28211|Alphaproteobacteria,2JTGR@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
k59_81004_2	1304865.JAGF01000001_gene204	2.97e-05	46.2	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria,4F23A@85016|Cellulomonadaceae	201174|Actinobacteria	K	ECF sigma factor	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_113290_1	1123392.AQWL01000002_gene1900	2.16e-121	379.0	COG3829@1|root,COG5001@1|root,COG5002@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,1KS9E@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_4
k59_863554_1	1229909.NSED_01295	5.71e-72	226.0	COG0649@1|root,arCOG01548@2157|Archaea,41S62@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_863554_2	1229909.NSED_01290	5.66e-42	142.0	COG0852@1|root,arCOG01551@2157|Archaea,41SJS@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase 27 kD subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_701539_1	1492737.FEM08_05150	0.000973	49.3	COG4191@1|root,COG4191@2|Bacteria,4PKDB@976|Bacteroidetes,1IJ83@117743|Flavobacteriia,2NUS8@237|Flavobacterium	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_307969_1	1299327.I546_2835	6.66e-15	75.9	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,233WB@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_307969_2	1214101.BN159_6093	2.27e-33	125.0	COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
k59_439040_1	1458357.BG58_05525	1.33e-167	492.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria,1JZQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_962410_1	987059.RBXJA2T_06860	3.48e-33	126.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,2VMTI@28216|Betaproteobacteria,1KJHM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_178532_1	1469245.JFBG01000057_gene2376	4.3e-47	160.0	COG4665@1|root,COG4665@2|Bacteria,1RG47@1224|Proteobacteria,1S3PZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_668745_1	706587.Desti_4248	1.32e-128	373.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_505374_2	1121904.ARBP01000011_gene1456	5.38e-18	82.0	COG0668@1|root,COG0668@2|Bacteria,4NMNE@976|Bacteroidetes,47XHW@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_929839_1	671143.DAMO_0818	3.52e-42	150.0	COG3005@1|root,COG3005@2|Bacteria,2NQ90@2323|unclassified Bacteria	2|Bacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	ko:K08354	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko02000	5.A.3.5	-	-	Cytochrome_C554,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1
k59_602924_1	552811.Dehly_0447	2.75e-91	278.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_145975_1	1429916.X566_06670	2.22e-13	66.6	COG3791@1|root,COG3791@2|Bacteria,1REMP@1224|Proteobacteria,2U61P@28211|Alphaproteobacteria,3JY6V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_145975_2	1122132.AQYH01000004_gene1748	8.22e-37	136.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,4B93D@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_404311_1	671143.DAMO_1184	3.84e-49	160.0	COG1895@1|root,COG1895@2|Bacteria,2NRN4@2323|unclassified Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
k59_404311_2	671143.DAMO_1183	1.27e-28	108.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86,NTP_transf_2
k59_373748_1	1229909.NSED_07775	3.39e-41	141.0	COG0020@1|root,arCOG01532@2157|Archaea,41S8J@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
k59_373748_2	436308.Nmar_1417	1e-73	223.0	COG0494@1|root,arCOG01078@2157|Archaea,41SPS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_373748_3	1229909.NSED_07785	2.65e-09	57.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_505381_1	1435356.Y013_16445	3.82e-15	69.7	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4G24Y@85025|Nocardiaceae	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_505381_2	1158150.KB906241_gene665	1.15e-38	141.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales	135613|Chromatiales	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_668751_1	381666.H16_A0703	7.79e-102	313.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,2VKSN@28216|Betaproteobacteria,1K51A@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SLT
k59_570647_1	237368.SCABRO_00954	1.16e-61	204.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_763346_1	697281.Mahau_0476	2.47e-62	200.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,42ET8@68295|Thermoanaerobacterales	186801|Clostridia	G	Transketolase, central region	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_733951_1	395961.Cyan7425_2480	7.12e-96	294.0	COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,3KFX6@43988|Cyanothece	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_404315_1	28229.ND2E_3370	1.15e-82	273.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q61E@267889|Colwelliaceae	1236|Gammaproteobacteria	U	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_469492_1	420662.Mpe_A2226	4.43e-53	177.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,1KKCN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	2-dehydropantoate 2-reductase	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_469492_2	1205680.CAKO01000042_gene5361	1.31e-36	130.0	COG0179@1|root,COG0179@2|Bacteria,1QUQP@1224|Proteobacteria	1224|Proteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase	MA20_15150	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_15643_1	644282.Deba_0084	3.78e-88	278.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1R561@1224|Proteobacteria,42NEB@68525|delta/epsilon subdivisions,2WM1V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CJ	Acetyl-CoA hydrolase transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
k59_210862_1	595537.Varpa_3007	7.81e-145	429.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,4AC1I@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM glycoside hydrolase, family 13 domain protein	-	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_145991_1	1229909.NSED_09285	4.61e-23	93.6	arCOG08767@1|root,arCOG08767@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_145991_2	436308.Nmar_1743	5.88e-13	66.2	arCOG10601@1|root,arCOG10601@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_308002_1	1458275.AZ34_02750	1.17e-16	78.6	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2WEXA@28216|Betaproteobacteria,4A9KB@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_308002_2	595537.Varpa_1076	2.29e-13	70.5	COG1846@1|root,COG1846@2|Bacteria,1N5CQ@1224|Proteobacteria,2VT0D@28216|Betaproteobacteria,4AF4J@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_635413_1	1489678.RDMS_12410	6.87e-35	125.0	29NZE@1|root,32WP7@2|Bacteria	2|Bacteria	S	Helix-turn-helix of DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_4
k59_701592_1	138119.DSY0416	1.34e-123	377.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,260N4@186807|Peptococcaceae	186801|Clostridia	C	formate C-acetyltransferase glycine radical	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_210878_1	883126.HMPREF9710_00723	1.03e-56	184.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2VRM9@28216|Betaproteobacteria,474A9@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Phosphoribosyl transferase domain	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_210878_2	269796.Rru_A0361	1.35e-16	78.6	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria,2JPTI@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_635421_1	382464.ABSI01000011_gene2516	5.86e-39	136.0	2E5IJ@1|root,3309Y@2|Bacteria,46YZF@74201|Verrucomicrobia,2IUSS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_635421_2	221288.JH992901_gene5050	1.22e-06	50.8	COG0612@1|root,COG0612@2|Bacteria,1G3GH@1117|Cyanobacteria,1JKK7@1189|Stigonemataceae	1117|Cyanobacteria	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_602964_1	1120948.KB903230_gene4926	1.19e-25	109.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4DXF2@85010|Pseudonocardiales	201174|Actinobacteria	C	FMN-dependent dehydrogenase	-	-	1.1.2.3,1.1.3.46	ko:K00101,ko:K16422	ko00261,ko00620,ko01055,ko01100,ko01130,map00261,map00620,map01055,map01100,map01130	-	R00196,R06633	RC00044,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_895742_1	522306.CAP2UW1_1041	2.46e-130	382.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,1KQAG@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Lipoprotein-releasing system permease protein	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_895742_2	1266925.JHVX01000005_gene1889	1.02e-49	164.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,372YT@32003|Nitrosomonadales	28216|Betaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_404346_1	1054213.HMPREF9946_00804	2.13e-29	112.0	COG1845@1|root,COG1845@2|Bacteria,1MXAB@1224|Proteobacteria,2TRFQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c oxidase, subunit III	coxO	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_404346_2	420324.KI912045_gene4451	2.15e-38	135.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2U0NA@28211|Alphaproteobacteria,1JTKP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM cytochrome c oxidase subunit III	coxP	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
k59_734004_1	932213.SPM24T3_21689	0.000224	48.5	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,1RNFV@1236|Gammaproteobacteria,4044T@613|Serratia	1236|Gammaproteobacteria	E	ornithine cyclodeaminase	ocd	-	1.5.1.1,1.5.1.49,1.5.1.51,4.3.1.12	ko:K01750,ko:K19742,ko:K19743,ko:K21721	ko00310,ko00330,ko00960,ko01100,ko01110,ko01130,ko01230,map00310,map00330,map00960,map01100,map01110,map01130,map01230	-	R00671,R01246,R01249,R02201,R02203	RC00135,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_832142_1	395494.Galf_1181	7.45e-63	204.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,44WDG@713636|Nitrosomonadales	28216|Betaproteobacteria	KLT	PFAM Serine threonine-protein kinase-like domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
k59_832142_2	159087.Daro_0439	5.29e-07	49.3	COG3063@1|root,COG3063@2|Bacteria,1PUFS@1224|Proteobacteria,2WATM@28216|Betaproteobacteria,2KZFJ@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1019497_1	7668.SPU_024462-tr	1.03e-24	110.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39NE5@33154|Opisthokonta,3CPYS@33208|Metazoa,3E63Y@33213|Bilateria	2759|Eukaryota	S	Endonuclease-reverse transcriptase	-	-	-	ko:K11320	-	-	-	-	ko00000,ko01000,ko03036	-	-	-	DUF4283,HSA,Helicase_C,SNF2_N,zf-CCHC_4
k59_242414_2	1283283.ATXA01000001_gene371	0.000435	43.1	COG2159@1|root,COG2159@2|Bacteria,2GKAB@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_995606_1	1000565.METUNv1_00368	1.25e-12	68.2	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,2KV3J@206389|Rhodocyclales	206389|Rhodocyclales	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	ppnK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_581389_1	580332.Slit_0812	1.73e-54	181.0	COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,2VQ5A@28216|Betaproteobacteria,44W6F@713636|Nitrosomonadales	28216|Betaproteobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K01802,ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase
k59_772763_1	1286631.X805_07270	1.62e-82	251.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,1KJZ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	enoyl-CoA hydratase	fadB3	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_250218_2	1144319.PMI16_02954	2.15e-49	162.0	COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,2VU7S@28216|Betaproteobacteria,474KD@75682|Oxalobacteraceae	28216|Betaproteobacteria	FG	HIT domain	hit	-	-	-	-	-	-	-	-	-	-	-	HIT
k59_792907_1	1396858.Q666_15910	8.87e-27	114.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4650G@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG0643 Chemotaxis protein histidine kinase and related kinases	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_26100_1	246194.CHY_2566	1.18e-07	57.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,42HU7@68295|Thermoanaerobacterales	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_26100_2	1463901.JOIY01000034_gene7268	5.23e-20	89.0	COG0745@1|root,COG0745@2|Bacteria,2GMP1@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_842947_1	335283.Neut_2237	4.66e-63	201.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2VHEW@28216|Betaproteobacteria,372K4@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_842947_2	56107.Cylst_1732	1.33e-40	147.0	COG0129@1|root,COG0129@2|Bacteria,1G0KD@1117|Cyanobacteria,1HITF@1161|Nostocales	1117|Cyanobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_973224_1	933262.AXAM01000017_gene3145	4.66e-100	322.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
k59_1024612_2	546267.NEIPOLOT_01940	3.35e-30	119.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,2KPIR@206351|Neisseriales	206351|Neisseriales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_478479_1	1121405.dsmv_0406	2.26e-77	238.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2MIAE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K04488,ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
k59_744783_1	944480.ATUV01000001_gene602	7.54e-83	259.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria	1224|Proteobacteria	Q	4-hydroxyphenylacetate	-	-	-	-	-	-	-	-	-	-	-	-	HpaB,HpaB_N
k59_449123_1	864051.BurJ1DRAFT_1558	4.17e-13	67.4	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,1KK10@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
k59_449123_2	1504672.669786344	4.58e-44	153.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,4AEEQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM thioesterase superfamily protein	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_123735_1	1123274.KB899412_gene1525	1.03e-59	204.0	COG0488@1|root,COG0488@2|Bacteria,2J5AN@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_220998_1	713586.KB900536_gene241	9.76e-58	195.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1X0AF@135613|Chromatiales	135613|Chromatiales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_352007_1	211165.AJLN01000005_gene3823	1.48e-75	244.0	COG3385@1|root,COG3385@2|Bacteria,1GGJ4@1117|Cyanobacteria,1JJPW@1189|Stigonemataceae	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_123736_1	338969.Rfer_4185	1.17e-66	212.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	ubiE	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
k59_792912_2	1121405.dsmv_2539	1.37e-62	208.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2MIIX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Elongation factor SelB winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_156490_1	748247.AZKH_4051	2.49e-72	235.0	COG0598@1|root,COG0598@2|Bacteria,1R7FC@1224|Proteobacteria,2VKBA@28216|Betaproteobacteria,2KUWR@206389|Rhodocyclales	206389|Rhodocyclales	P	Magnesium transport protein CorA	-	-	-	-	-	-	-	-	-	-	-	-	CorA
k59_478485_1	1408428.JNJP01000130_gene3846	1.63e-63	210.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2M8NM@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_156491_1	1459636.NTE_01051	7.55e-79	256.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18593	ko00720,ko01120,map00720,map01120	-	R10758	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_91726_1	1163617.SCD_n00287	9.51e-147	428.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_973250_1	332101.JIBU02000042_gene1486	3.83e-15	76.3	COG0745@1|root,COG0745@2|Bacteria,1TT2Z@1239|Firmicutes,248PN@186801|Clostridia,36DR9@31979|Clostridiaceae	186801|Clostridia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_250250_1	1229909.NSED_05290	6.52e-68	216.0	COG2064@1|root,arCOG01808@2157|Archaea	2157|Archaea	NU	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
k59_536901_1	1120792.JAFV01000001_gene1751	1.72e-85	262.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,36X8A@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Protein of unknown function (DUF933)	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_581434_1	614083.AWQR01000026_gene3558	2.11e-72	242.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,4AC69@80864|Comamonadaceae	28216|Betaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_940578_1	697282.Mettu_0567	6.03e-93	290.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1XE30@135618|Methylococcales	1236|Gammaproteobacteria	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	treZ	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_613341_1	1235802.C823_05409	2.64e-71	231.0	COG1321@1|root,COG1321@2|Bacteria,1UZX6@1239|Firmicutes,248DA@186801|Clostridia	186801|Clostridia	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_792915_1	1121875.KB907548_gene1476	2.69e-81	249.0	COG5553@1|root,COG5553@2|Bacteria,4NJMB@976|Bacteroidetes,1I0CQ@117743|Flavobacteriia	976|Bacteroidetes	S	Cysteine dioxygenase type I	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_279395_2	382464.ABSI01000013_gene1626	1.61e-07	52.8	COG0451@1|root,COG0451@2|Bacteria,46UBJ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	3-beta hydroxysteroid dehydrogenase	-	-	1.1.1.412	ko:K22320	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD
k59_842986_1	682795.AciX8_1390	3.02e-24	99.0	COG1905@1|root,COG1905@2|Bacteria,3Y4SI@57723|Acidobacteria,2JJDP@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_842986_2	945713.IALB_2121	6.29e-24	99.0	COG0649@1|root,COG0649@2|Bacteria	2|Bacteria	C	NAD binding	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
k59_383625_1	1040986.ATYO01000067_gene2969	2.64e-14	67.8	COG3385@1|root,COG3385@2|Bacteria,1R27B@1224|Proteobacteria,2TZCB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_383625_2	318586.Pden_2704	1.13e-63	196.0	COG3293@1|root,COG3293@2|Bacteria,1REED@1224|Proteobacteria,2U78B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_772811_1	864051.BurJ1DRAFT_1568	2.17e-46	158.0	COG4795@1|root,COG4795@2|Bacteria,1N6ZJ@1224|Proteobacteria,2VURU@28216|Betaproteobacteria,1KMB4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	General secretion pathway protein	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
k59_250262_1	1288494.EBAPG3_7950	1.92e-65	221.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3725J@32003|Nitrosomonadales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_449151_1	670292.JH26_23590	3.21e-57	187.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2VGUT@28211|Alphaproteobacteria,1JZ85@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
k59_613359_1	1089552.KI911559_gene3649	8.45e-93	286.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,2JU7J@204441|Rhodospirillales	204441|Rhodospirillales	L	DDE (Asp,Asp,Glu) domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_221036_2	1443665.JACA01000007_gene103	9.71e-25	99.0	COG2318@1|root,COG2318@2|Bacteria,4NU20@976|Bacteroidetes,1IMA1@117743|Flavobacteriia,2YIVT@290174|Aquimarina	976|Bacteroidetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
k59_1004307_1	706587.Desti_4814	1.01e-16	85.9	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MQ98@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	xdhA	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_352041_1	572547.Amico_1296	4e-43	155.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
k59_279406_1	420662.Mpe_A3338	1.03e-66	218.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2VIUF@28216|Betaproteobacteria,1KKP5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	ddc	-	4.1.1.86	ko:K13745	ko00260,ko01120,map00260,map01120	-	R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
k59_450228_1	1219045.BV98_003857	1.85e-99	320.0	COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,2U4DF@28211|Alphaproteobacteria,2K18I@204457|Sphingomonadales	204457|Sphingomonadales	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
k59_537450_2	990285.RGCCGE502_15265	3.23e-56	185.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,4B9EZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter, ATP-binding protein	MA20_09455	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_353131_1	1454004.AW11_02733	3.56e-68	222.0	COG0664@1|root,COG0668@1|root,COG0664@2|Bacteria,COG0668@2|Bacteria,1R6J6@1224|Proteobacteria,2VPCU@28216|Betaproteobacteria	28216|Betaproteobacteria	MT	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
k59_189610_1	159087.Daro_2982	2.76e-60	198.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,2KVKZ@206389|Rhodocyclales	206389|Rhodocyclales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_450237_1	289376.THEYE_A1749	1.42e-24	96.7	COG1371@1|root,COG1371@2|Bacteria	2|Bacteria	J	PFAM Archease protein family (DUF101 UPF0211)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
k59_450237_2	374847.Kcr_1407	2.84e-11	64.3	COG1690@1|root,arCOG04246@2157|Archaea	2157|Archaea	L	Belongs to the RtcB family	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
k59_189612_1	986075.CathTA2_0026	5.54e-33	129.0	COG2801@1|root,COG2801@2|Bacteria,1TT8V@1239|Firmicutes,4HCE5@91061|Bacilli	91061|Bacilli	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_29,rve
k59_280002_1	1121468.AUBR01000012_gene2601	2.57e-05	45.1	2F0YS@1|root,33U0E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_280002_2	589924.Ferp_1471	1.69e-36	137.0	COG1804@1|root,arCOG02304@2157|Archaea,2XTW7@28890|Euryarchaeota,246VM@183980|Archaeoglobi	28890|Euryarchaeota	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_27253_1	96561.Dole_1717	9.69e-40	133.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,43BIE@68525|delta/epsilon subdivisions,2X6WS@28221|Deltaproteobacteria,2MKKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_875094_1	330214.NIDE3384	3.16e-92	300.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,3J0SV@40117|Nitrospirae	40117|Nitrospirae	C	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_582611_1	644282.Deba_0463	1.17e-41	155.0	COG1750@1|root,COG1750@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Lon_C,SdrD_B
k59_646787_1	1366050.N234_09885	1.12e-14	72.8	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2VICA@28216|Betaproteobacteria,1K65J@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_646787_2	1244869.H261_13214	2.23e-38	137.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2TV8K@28211|Alphaproteobacteria,2JU79@204441|Rhodospirillales	204441|Rhodospirillales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_773657_1	1163617.SCD_n00045	7.56e-80	243.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the LOG family	yvdD_2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_974450_1	1380394.JADL01000018_gene1895	2.36e-81	252.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,2U069@28211|Alphaproteobacteria,2JQB1@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_646793_1	472759.Nhal_1338	3.29e-25	108.0	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,1RNQ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_353153_1	439235.Dalk_5062	2.95e-48	163.0	COG1035@1|root,COG4656@1|root,COG1035@2|Bacteria,COG4656@2|Bacteria,1NQN7@1224|Proteobacteria,42MGI@68525|delta/epsilon subdivisions,2WKNC@28221|Deltaproteobacteria,2MIJN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrD	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_17,Fer4_8,FlpD,FrhB_FdhB_C
k59_353153_2	1121396.KB893100_gene4318	5.16e-20	83.6	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RJZ@68525|delta/epsilon subdivisions,2WNDU@28221|Deltaproteobacteria,2MJUB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_353153_3	933262.AXAM01000017_gene3144	1.86e-42	138.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42T3M@68525|delta/epsilon subdivisions,2WPVI@28221|Deltaproteobacteria,2MKVM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_353153_4	635013.TherJR_0937	8.32e-06	47.4	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,2673V@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,Pyr_redox_2
k59_414444_1	1121127.JAFA01000090_gene3621	3.27e-110	329.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VNU5@28216|Betaproteobacteria,1K1AA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_745987_1	1123269.NX02_19715	4.41e-77	242.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2K3IJ@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_291886_1	244447.XP_008329218.1	1.01e-12	72.0	COG1028@1|root,KOG1200@2759|Eukaryota,39S00@33154|Opisthokonta,3BGVB@33208|Metazoa,3CXFR@33213|Bilateria,487AN@7711|Chordata,498KG@7742|Vertebrata,49XQT@7898|Actinopterygii	33208|Metazoa	Q	Hydroxysteroid (17-beta) dehydrogenase 8	HSD17B8	GO:0000166,GO:0003674,GO:0003824,GO:0003857,GO:0004303,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006694,GO:0006703,GO:0008150,GO:0008152,GO:0008202,GO:0008209,GO:0008210,GO:0008610,GO:0009058,GO:0009987,GO:0010817,GO:0016020,GO:0016043,GO:0016053,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0031967,GO:0031974,GO:0031975,GO:0032787,GO:0033764,GO:0034754,GO:0036094,GO:0042445,GO:0042446,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0047025,GO:0047035,GO:0048037,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0051290,GO:0051291,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070404,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	1.1.1.239,1.1.1.62	ko:K13370	ko00140,ko01100,map00140,map01100	-	R01836,R02352,R02353,R04681,R04682,R08945,R08980	RC00127,RC00261	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_291931_1	1288494.EBAPG3_26910	1.14e-52	176.0	COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,2VN04@28216|Betaproteobacteria,372SJ@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Fructosamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_291931_2	228410.NE1854	4.03e-34	129.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,371N1@32003|Nitrosomonadales	28216|Betaproteobacteria	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_291939_1	526222.Desal_3192	3.48e-60	197.0	COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,42MA1@68525|delta/epsilon subdivisions,2WPWQ@28221|Deltaproteobacteria,2M958@213115|Desulfovibrionales	28221|Deltaproteobacteria	EJ	Asparaginase glutaminase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_1035743_1	1247649.D560_3828	5.28e-95	286.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2VN7F@28216|Betaproteobacteria,3T7ZU@506|Alcaligenaceae	28216|Betaproteobacteria	L	Transposase for IS481 element	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
k59_551291_1	398525.KB900702_gene250	2.55e-99	301.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,3JT6Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DUF772
k59_1035747_1	204773.HEAR0116	3.76e-65	211.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,47340@75682|Oxalobacteraceae	28216|Betaproteobacteria	LU	DNA recombination-mediator protein A	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_804428_1	999541.bgla_2g18110	1.66e-75	233.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,1K2CE@119060|Burkholderiaceae	28216|Betaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_551368_1	1286631.X805_01760	6.58e-93	293.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1KIY8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
k59_551379_1	205922.Pfl01_1853	6.22e-19	92.4	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1S4IM@1236|Gammaproteobacteria,1YPMC@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	pvdM	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_292040_1	1276756.AUEX01000002_gene486	1.73e-40	146.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKW3@28216|Betaproteobacteria,4ABRG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_292051_1	1461577.CCMH01000011_gene1772	2.15e-37	139.0	COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,1I0PW@117743|Flavobacteriia	976|Bacteroidetes	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_551403_2	530564.Psta_3946	5.13e-44	155.0	COG0065@1|root,COG0065@2|Bacteria,2IXHR@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_292080_1	640081.Dsui_1818	1.81e-68	219.0	COG0547@1|root,COG0547@2|Bacteria,1QJ8Q@1224|Proteobacteria,2VH2D@28216|Betaproteobacteria,2KVGU@206389|Rhodocyclales	206389|Rhodocyclales	E	glycosyl transferase family	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_292084_1	1089545.KB913037_gene1817	3.13e-71	227.0	COG1960@1|root,COG1960@2|Bacteria,2GJ7S@201174|Actinobacteria,4E1DY@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,Thioesterase
k59_1035866_1	243231.GSU1277	1.9e-71	219.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,42SDX@68525|delta/epsilon subdivisions,2WP41@28221|Deltaproteobacteria,43SYB@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_292114_1	573065.Astex_3119	4.23e-22	95.9	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,2KF8E@204458|Caulobacterales	204458|Caulobacterales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_292114_2	671143.DAMO_2645	1.28e-22	98.2	COG0751@1|root,COG0751@2|Bacteria,2NNWY@2323|unclassified Bacteria	2|Bacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	DALR_1,tRNA_synt_2f
k59_804556_1	1286631.X805_08820	4.6e-103	308.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria,1KJUS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_292150_2	1090319.KE386571_gene2082	3.61e-11	63.5	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,2K17I@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_804601_1	1123253.AUBD01000005_gene281	6.66e-39	142.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1X2XK@135614|Xanthomonadales	135614|Xanthomonadales	O	Cysteine desulfurase activator complex subunit SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_292160_1	28229.ND2E_1880	8.91e-83	264.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,1RQ1A@1236|Gammaproteobacteria,2Q6Q9@267889|Colwelliaceae	1236|Gammaproteobacteria	M	PFAM membrane bound O-acyl transferase MBOAT family protein	algI	-	-	-	-	-	-	-	-	-	-	-	MBOAT
k59_804622_1	1452718.JBOY01000004_gene3133	5.03e-33	126.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RQ07@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase	rubB	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Rubredoxin
k59_804633_1	186497.PF0369	8.57e-13	73.6	COG1363@1|root,arCOG01519@2157|Archaea,2XTBH@28890|Euryarchaeota,2432Z@183968|Thermococci	183968|Thermococci	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_551541_1	1121447.JONL01000001_gene1002	2.72e-63	199.0	COG1853@1|root,COG1853@2|Bacteria,1RBSR@1224|Proteobacteria,42R0G@68525|delta/epsilon subdivisions,2WMYE@28221|Deltaproteobacteria,2MAM7@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_292196_1	323848.Nmul_A0555	1.59e-19	86.7	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,372PY@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
k59_292196_2	999541.bgla_1g06090	1.42e-59	186.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,1K791@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Required for insertion of 4Fe-4S clusters	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_804697_1	1123487.KB892857_gene2361	8.82e-68	220.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,2KV06@206389|Rhodocyclales	206389|Rhodocyclales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
k59_804711_1	316055.RPE_3213	1e-115	354.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,3JQT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4,1.2.5.3,1.3.7.9	ko:K00087,ko:K03520,ko:K04108	ko00230,ko00362,ko00627,ko01100,ko01120,ko01220,map00230,map00362,map00627,map01100,map01120,map01220	M00546	R01768,R02103,R05316,R11168	RC00143,RC00490,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_804716_1	996637.SGM_4629	1.76e-05	51.6	COG0712@1|root,COG0712@2|Bacteria,2GMJ5@201174|Actinobacteria	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
k59_804755_1	323848.Nmul_A2486	4.48e-118	348.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,371UP@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidase family M23	-	-	3.4.24.75	ko:K08259	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_804755_2	987059.RBXJA2T_06995	4.45e-110	346.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,1KITH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1036088_1	945713.IALB_0028	2.15e-08	54.3	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_804809_2	768710.DesyoDRAFT_5443	8.91e-08	57.4	COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,260IK@186807|Peptococcaceae	186801|Clostridia	J	Elongation factor Tu domain 2	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_1036089_1	365044.Pnap_4081	6.36e-61	201.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJBE@28216|Betaproteobacteria,4AJ0F@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_292376_2	633148.Tagg_0120	1.49e-28	115.0	COG2414@1|root,arCOG00706@2157|Archaea,2XPT1@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_849938_1	648885.KB316283_gene3107	7.01e-22	97.4	COG2232@1|root,COG2232@2|Bacteria,1R6Y7@1224|Proteobacteria,2TRBR@28211|Alphaproteobacteria,1JT87@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
k59_849938_2	1000565.METUNv1_01449	4.67e-32	119.0	COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,2VK09@28216|Betaproteobacteria,2KZYB@206389|Rhodocyclales	28216|Betaproteobacteria	H	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
k59_882491_1	385682.AFSL01000047_gene521	1.48e-51	180.0	COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,2FM28@200643|Bacteroidia,3XJ12@558415|Marinilabiliaceae	976|Bacteroidetes	I	Acyl-CoA dehydrogenase C terminal	acd	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_dehyd_C
k59_686839_1	1206739.BAGJ01000133_gene855	4.26e-118	349.0	COG1960@1|root,COG1960@2|Bacteria,2GJX5@201174|Actinobacteria,4FXG8@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	fadE12_3	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_621529_1	1144342.PMI40_01008	1.13e-44	157.0	COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2VN9Q@28216|Betaproteobacteria,478FZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_392860_1	224308.BSU23560	3.51e-26	111.0	COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,4HA18@91061|Bacilli,1ZBQN@1386|Bacillus	91061|Bacilli	C	Na H antiporter	mleN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_458156_1	1267005.KB911258_gene303	4.83e-135	391.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_817500_1	557599.MKAN_06595	8.8e-40	151.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
k59_915401_1	706587.Desti_1917	3.17e-89	263.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,43B7N@68525|delta/epsilon subdivisions,2X6M3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
k59_915401_2	56780.SYN_01646	1.67e-18	82.0	COG1414@1|root,COG1908@1|root,COG1414@2|Bacteria,COG1908@2|Bacteria,1RDMH@1224|Proteobacteria,42RX1@68525|delta/epsilon subdivisions,2WNT8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CK	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD,HTH_5
k59_99150_1	398767.Glov_1922	1.41e-15	78.2	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,43BBA@68525|delta/epsilon subdivisions,2X6QG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_99150_2	330214.NIDE3065	2.82e-48	168.0	COG4942@1|root,COG4942@2|Bacteria,3J0SP@40117|Nitrospirae	40117|Nitrospirae	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_719404_1	883.DvMF_2382	2.06e-05	46.6	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2M9IV@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_719404_2	523791.Kkor_1486	3.83e-12	69.3	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XIW5@135619|Oceanospirillales	135619|Oceanospirillales	NU	Tfp pilus assembly protein	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM,TPR_19
k59_458162_1	1321778.HMPREF1982_02247	3.35e-90	290.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,267T0@186813|unclassified Clostridiales	186801|Clostridia	KL	HELICc2	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
k59_66544_2	1250232.JQNJ01000001_gene3216	5.41e-30	114.0	COG3000@1|root,COG3000@2|Bacteria,4NI62@976|Bacteroidetes,1I9FZ@117743|Flavobacteriia	976|Bacteroidetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_915422_1	1123277.KB893183_gene33	7.25e-67	214.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_5,DDE_Tnp_1
k59_458174_1	1150626.PHAMO_290062	5.27e-50	180.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQ4H@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_7,PAS_9,dCache_1,dCache_2
k59_197145_1	948106.AWZT01000035_gene2440	5.19e-112	350.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,1K0RR@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_751918_1	520709.F985_02722	2.41e-28	115.0	COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,1RQD9@1236|Gammaproteobacteria,3NSQ9@468|Moraxellaceae	1236|Gammaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH,SnoaL_2
k59_882507_1	1357714.A0A067XR00_9CAUD	2.65e-06	59.7	4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses  no RNA stage,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae	10662|Myoviridae	S	Pfam:DUF4815	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_164447_1	1089551.KE386572_gene3803	9.56e-77	244.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,4BP6H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_817531_1	78245.Xaut_1332	2.04e-21	93.2	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3EYTK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_817531_2	1125973.JNLC01000001_gene83	5.5e-24	99.0	2D22U@1|root,3160H@2|Bacteria,1N7N1@1224|Proteobacteria,2UH8D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_360225_1	123899.JPQP01000022_gene3291	9.99e-70	232.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,3T3BV@506|Alcaligenaceae	28216|Betaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_229656_1	269799.Gmet_1972	8.82e-77	236.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42NHY@68525|delta/epsilon subdivisions,2WKAP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_66569_1	402881.Plav_1523	1.69e-61	196.0	COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2TTDD@28211|Alphaproteobacteria,1JP42@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_66569_2	1121035.AUCH01000021_gene2706	1.57e-72	225.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,2KW8U@206389|Rhodocyclales	206389|Rhodocyclales	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_915447_1	1095769.CAHF01000011_gene2231	2.46e-54	189.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,472UR@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_915447_2	1485544.JQKP01000007_gene1938	3.72e-80	253.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,44V27@713636|Nitrosomonadales	28216|Betaproteobacteria	M	SMART PDZ DHR GLGF domain protein	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_327758_1	945713.IALB_0147	2.95e-45	165.0	COG2234@1|root,COG4412@1|root,COG2234@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.4.11.10,3.4.21.50	ko:K01337,ko:K05994,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF4968,DUF5110,F5_F8_type_C,Glyco_hydro_31,PA,Peptidase_M28,Peptidase_M6,Peptidase_S8,W_rich_C
k59_556365_1	396588.Tgr7_1020	8.45e-33	122.0	2E55J@1|root,302RV@2|Bacteria,1RFMA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_556365_2	396588.Tgr7_1023	1.39e-26	99.4	COG4327@1|root,COG4327@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4212)	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	DUF4212
k59_491062_1	296591.Bpro_1912	1.75e-88	269.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2VMW1@28216|Betaproteobacteria,4ACV0@80864|Comamonadaceae	28216|Betaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
k59_491062_2	1122604.JONR01000001_gene1771	1.74e-44	157.0	COG4638@1|root,COG4638@2|Bacteria,1MXXI@1224|Proteobacteria,1RRNX@1236|Gammaproteobacteria,1X5GW@135614|Xanthomonadales	135614|Xanthomonadales	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_458197_1	640081.Dsui_2678	1.64e-57	188.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,2KVFV@206389|Rhodocyclales	206389|Rhodocyclales	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_99191_1	234267.Acid_4295	3.91e-63	206.0	COG2208@1|root,COG4753@1|root,COG2208@2|Bacteria,COG4753@2|Bacteria,3Y6AE@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
k59_923261_1	395494.Galf_2123	1.85e-66	217.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,44VEU@713636|Nitrosomonadales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_498885_1	543728.Vapar_5340	2.51e-35	131.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2VJR6@28216|Betaproteobacteria,4AA73@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_9038_1	395495.Lcho_3890	4.14e-16	80.1	COG1999@1|root,COG1999@2|Bacteria,1R725@1224|Proteobacteria,2W1XA@28216|Betaproteobacteria,1KNI5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	SCO1-SenC
k59_727256_1	1337936.IJ00_01210	5e-61	197.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria,1HRP9@1161|Nostocales	1117|Cyanobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_41408_1	1122237.AUGQ01000014_gene2672	4.75e-28	113.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria,4FNBP@85023|Microbacteriaceae	201174|Actinobacteria	IQ	KR domain	gno	-	1.1.1.100,1.1.1.69	ko:K00046,ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_204558_1	1411123.JQNH01000001_gene560	2.29e-45	161.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_74413_1	1353529.M899_2969	0.000221	48.5	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2MSU3@213481|Bdellovibrionales,2WIZB@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_172089_1	1492922.GY26_12760	4.31e-78	259.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1J4XZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_269992_1	7213.XP_004527676.1	2.61e-105	315.0	29KCI@1|root,2RTMD@2759|Eukaryota,3APRA@33154|Opisthokonta	33154|Opisthokonta	S	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_5
k59_498892_2	1121875.KB907546_gene2204	9e-170	492.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia	976|Bacteroidetes	Q	Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_74417_1	1499967.BAYZ01000074_gene2122	0.000202	48.9	COG1807@1|root,COG1807@2|Bacteria,2NRDV@2323|unclassified Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_204570_1	948106.AWZT01000006_gene3275	7.12e-59	193.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2VHEU@28216|Betaproteobacteria,1K3QR@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_204570_2	1260251.SPISAL_01270	1.15e-42	152.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_857353_1	323848.Nmul_A0190	4.55e-22	91.7	COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria,3739N@32003|Nitrosomonadales	28216|Betaproteobacteria	S	signal sequence binding	sco1	-	-	-	-	-	-	-	-	-	-	-	-
k59_857353_2	1000565.METUNv1_02097	2.88e-14	72.4	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,2KVHR@206389|Rhodocyclales	206389|Rhodocyclales	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_433839_1	113395.AXAI01000008_gene898	3.74e-19	90.1	COG2404@1|root,COG2404@2|Bacteria,1MXEH@1224|Proteobacteria,2U76B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	phosphoesterase DHHA1	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
k59_597580_1	765910.MARPU_11530	6.07e-30	121.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_399974_1	397945.Aave_2024	2.07e-148	437.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2W14D@28216|Betaproteobacteria,4AJPK@80864|Comamonadaceae	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_336294_1	1120956.JHZK01000025_gene2004	6.23e-67	223.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,1JP1J@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	MA20_23745	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_663152_2	1049564.TevJSym_am00850	1.92e-07	53.9	COG3866@1|root,COG4625@1|root,COG3866@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1T4RN@1236|Gammaproteobacteria,1JC2H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	outer membrane autotransporter barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_205587_1	760117.JN27_10200	6.87e-79	254.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,472AJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_42517_1	1175306.GWL_32370	3.03e-57	181.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2VR9M@28216|Betaproteobacteria,4749Z@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Thioesterase superfamily	yciA	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
k59_42517_2	1000565.METUNv1_02316	2.97e-22	96.3	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,2KV6D@206389|Rhodocyclales	206389|Rhodocyclales	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1016655_2	342113.DM82_483	6.71e-47	157.0	COG4574@1|root,COG4574@2|Bacteria,1MZEN@1224|Proteobacteria,2VUFF@28216|Betaproteobacteria,1K90E@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the protease inhibitor I11 (ecotin) family	eco	-	-	ko:K08276	-	-	-	-	ko00000	-	-	-	Ecotin
k59_465126_2	1323663.AROI01000016_gene419	5.57e-09	57.4	COG4795@1|root,COG4795@2|Bacteria	2|Bacteria	U	General secretion pathway protein	gspJ	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
k59_988819_1	987059.RBXJA2T_04958	1.01e-105	319.0	COG4656@1|root,COG4656@2|Bacteria,1PJVF@1224|Proteobacteria,2VM4P@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N,SLBB
k59_758962_1	1122201.AUAZ01000046_gene2158	1.35e-10	62.4	COG1846@1|root,COG1846@2|Bacteria,1N7BV@1224|Proteobacteria,1SHPZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR
k59_695923_1	1249997.JHZW01000003_gene3775	0.00029	46.6	COG2133@1|root,COG2133@2|Bacteria,4NH6W@976|Bacteroidetes,1I07N@117743|Flavobacteriia,2PHWI@252356|Maribacter	976|Bacteroidetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_499985_1	335543.Sfum_0325	4.59e-85	255.0	COG0655@1|root,COG0655@2|Bacteria,1RAK6@1224|Proteobacteria,42QS5@68525|delta/epsilon subdivisions,2WN2M@28221|Deltaproteobacteria,2MQXT@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_173218_2	32057.KB217478_gene3290	3.94e-35	127.0	COG0500@1|root,COG2226@2|Bacteria,1GK4A@1117|Cyanobacteria,1HQAZ@1161|Nostocales	1117|Cyanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_10173_1	266117.Rxyl_2895	9.12e-26	105.0	COG3548@1|root,COG3548@2|Bacteria,2GRE3@201174|Actinobacteria,4CTPZ@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
k59_630088_1	330214.NIDE1344	3.9e-127	376.0	COG1508@1|root,COG1508@2|Bacteria,3J0AT@40117|Nitrospirae	40117|Nitrospirae	K	Sigma-54 factor, Activator interacting domain (AID)	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_140591_1	925409.KI911562_gene342	6.65e-34	127.0	COG0730@1|root,COG0730@2|Bacteria,4NIJ9@976|Bacteroidetes,1IRF7@117747|Sphingobacteriia	976|Bacteroidetes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_597609_1	243231.GSU2327	1.4e-60	200.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,42N4S@68525|delta/epsilon subdivisions,2WJXX@28221|Deltaproteobacteria,43UK3@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_858421_1	864051.BurJ1DRAFT_2792	3.19e-137	405.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,1KJ35@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_758971_2	1214166.ALLG01000021_gene16	1.28e-13	75.1	COG0860@1|root,COG1705@1|root,COG0860@2|Bacteria,COG1705@2|Bacteria,1W25V@1239|Firmicutes,4HGXW@91061|Bacilli,1WS9V@1307|Streptococcus suis	91061|Bacilli	M	GBS Bsp-like repeat	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,CHAP,GBS_Bsp-like,Glyco_hydro_25,Peptidase_C39_2
k59_433887_1	1166948.JPZL01000001_gene2169	3.85e-58	187.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XJQK@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_728417_1	748247.AZKH_2982	2.49e-14	73.6	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,2KUVU@206389|Rhodocyclales	206389|Rhodocyclales	O	Zn-dependent protease with chaperone function	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_728417_2	748247.AZKH_2981	3.52e-90	268.0	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,2VIA2@28216|Betaproteobacteria,2KW4Q@206389|Rhodocyclales	206389|Rhodocyclales	A	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
k59_728417_3	1121939.L861_17180	1.04e-22	89.0	2E7PS@1|root,3325B@2|Bacteria,1QNSP@1224|Proteobacteria,1SI7D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_728417_4	1249627.D779_1587	4.22e-158	464.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1WXDW@135613|Chromatiales	135613|Chromatiales	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_236744_1	640081.Dsui_1013	6.35e-17	74.3	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2VVVB@28216|Betaproteobacteria,2KX6R@206389|Rhodocyclales	206389|Rhodocyclales	H	COG2104 Sulfur transfer protein involved in thiamine biosynthesis	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_236744_2	1502770.JQMG01000001_gene788	9.62e-149	423.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2VJ8T@28216|Betaproteobacteria,2KKDX@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
k59_236744_3	62928.azo3968	7.89e-38	134.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,2KUWG@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_826504_1	287.DR97_937	1.23e-52	174.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1YEZC@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2492,iJN746.PP_1237,iYL1228.KPN_02812	DHDPS
k59_107972_1	1000565.METUNv1_03272	3.48e-72	231.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,2KV07@206389|Rhodocyclales	206389|Rhodocyclales	E	amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_140620_1	1070319.CAGGBEG34_220015	3e-25	102.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VPPY@28216|Betaproteobacteria,1K2BW@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_140620_2	999541.bgla_1g05030	1.34e-26	107.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,1K1ZW@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_173252_1	1191523.MROS_2800	2.95e-79	248.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gluD	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.gdhA	ELFV_dehydrog,ELFV_dehydrog_N
k59_630121_1	765912.Thimo_0384	1.55e-130	378.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1WWXU@135613|Chromatiales	135613|Chromatiales	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_271088_1	1449058.JQKT01000007_gene1523	6.39e-41	148.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta
k59_890610_1	935557.ATYB01000014_gene4619	1.63e-42	144.0	COG3791@1|root,COG3791@2|Bacteria,1RBIH@1224|Proteobacteria,2U5D0@28211|Alphaproteobacteria,4BEY0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_400036_1	1123392.AQWL01000007_gene889	1.39e-25	106.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,1KRI7@119069|Hydrogenophilales	119069|Hydrogenophilales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_400036_2	153948.NAL212_0569	1.95e-61	194.0	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2VSKW@28216|Betaproteobacteria,3738M@32003|Nitrosomonadales	28216|Betaproteobacteria	T	low molecular weight	ptpA	GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_465169_1	404589.Anae109_2135	2.36e-11	65.9	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria,2YWMX@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1716	ECH_1
k59_1016689_1	926569.ANT_09770	2.59e-132	390.0	COG0008@1|root,COG0008@2|Bacteria,2G5WU@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_173274_1	379731.PST_3288	1.18e-63	207.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1Z1ME@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	COG0436 Aspartate tyrosine aromatic aminotransferase	IV02_28760	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_1016690_1	1123393.KB891316_gene1804	3.77e-79	252.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,1KRCP@119069|Hydrogenophilales	119069|Hydrogenophilales	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_663250_1	269799.Gmet_0053	3.12e-24	105.0	COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,42R14@68525|delta/epsilon subdivisions,2WN3R@28221|Deltaproteobacteria,43TZR@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_205676_1	1380391.JIAS01000012_gene3966	6.26e-38	144.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JR4P@204441|Rhodospirillales	204441|Rhodospirillales	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_728478_1	330214.NIDE2574	5.31e-109	328.0	COG0138@1|root,COG0138@2|Bacteria,3J0CV@40117|Nitrospirae	40117|Nitrospirae	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_696018_1	1298867.AUES01000056_gene4783	1.25e-84	260.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,3JR0C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_630169_1	1385515.N791_03625	6.74e-21	95.5	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1X4F6@135614|Xanthomonadales	135614|Xanthomonadales	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_988910_1	1146883.BLASA_1673	9.21e-70	228.0	COG3333@1|root,COG3333@2|Bacteria,2GJB2@201174|Actinobacteria,4EVM2@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_956942_1	1288494.EBAPG3_24400	3.16e-94	291.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,37277@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_236796_1	1463825.JNXC01000007_gene830	2.05e-76	244.0	COG0154@1|root,COG0154@2|Bacteria,2GN7F@201174|Actinobacteria,4DZAM@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_42629_1	1131814.JAFO01000001_gene1989	5.24e-51	164.0	COG2329@1|root,COG2329@2|Bacteria,1RGVV@1224|Proteobacteria,2U9A3@28211|Alphaproteobacteria,3F1PD@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_42629_2	556269.ACDQ01000010_gene1872	1.53e-33	126.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2VPE5@28216|Betaproteobacteria,4764N@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Saccharopine dehydrogenase C-terminal domain	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_858510_1	1500894.JQNN01000001_gene2812	2.61e-99	314.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,472B9@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_303147_1	1265502.KB905937_gene2591	5.74e-134	397.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,4AACX@80864|Comamonadaceae	28216|Betaproteobacteria	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_500097_1	1247963.JPHU01000007_gene1607	8.38e-81	267.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
k59_696040_1	1121861.KB899911_gene1278	2.4e-12	66.6	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,2JQI9@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_696040_2	935863.AWZR01000001_gene1747	1.08e-17	77.0	COG4327@1|root,COG4327@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4212)	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	DUF4212
k59_377182_1	748280.NH8B_0001	1.06e-25	105.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,2KPIA@206351|Neisseriales	206351|Neisseriales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_377182_2	323848.Nmul_A0002	3.21e-157	453.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,371UF@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_377182_3	323848.Nmul_A0003	0.0	1178.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3725J@32003|Nitrosomonadales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_835736_1	1168034.FH5T_10400	3.89e-71	240.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes,2FM1V@200643|Bacteroidia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_766451_1	1429916.X566_18170	2.92e-56	188.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TV37@28211|Alphaproteobacteria,3JRUP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	MA20_19440	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_442472_1	1380394.JADL01000002_gene1437	2.17e-79	239.0	2C02K@1|root,32R69@2|Bacteria,1RK2Q@1224|Proteobacteria,2U9PI@28211|Alphaproteobacteria,2JT3N@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_638813_2	1211115.ALIQ01000188_gene624	7.62e-37	134.0	COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,2TUK3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydrolases of HD superfamily	-	-	-	ko:K06952	-	-	-	-	ko00000	-	-	-	-
k59_508962_1	595494.Tola_0389	4.78e-112	329.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1Y4E5@135624|Aeromonadales	135624|Aeromonadales	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_311245_1	652103.Rpdx1_3803	5.28e-16	79.3	COG0583@1|root,COG0583@2|Bacteria,1MUNN@1224|Proteobacteria,2VEUG@28211|Alphaproteobacteria,3JUT2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator, LysR family	MA20_18660	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_311245_2	1188252.AJYK01000007_gene2758	4.05e-08	53.1	COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,1RQ79@1236|Gammaproteobacteria,1XTVN@135623|Vibrionales	135623|Vibrionales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_790059_1	439235.Dalk_4190	5.24e-61	206.0	COG1996@1|root,COG1996@2|Bacteria,1R71V@1224|Proteobacteria,42PRX@68525|delta/epsilon subdivisions,2WMQY@28221|Deltaproteobacteria,2MIG3@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_898941_1	981384.AEYW01000001_gene1543	9.55e-57	189.0	COG1638@1|root,COG1638@2|Bacteria,1MUJY@1224|Proteobacteria,2TQNU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_149579_2	1177594.MIC448_1540002	4.81e-13	70.9	COG0526@1|root,COG0526@2|Bacteria,2IET9@201174|Actinobacteria	201174|Actinobacteria	CO	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_737637_1	290512.Paes_0935	1.38e-40	149.0	COG4339@1|root,COG4339@2|Bacteria,1FEGB@1090|Chlorobi	1090|Chlorobi	S	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_835747_1	204669.Acid345_2790	2.96e-89	278.0	COG1249@1|root,COG1249@2|Bacteria,3Y2M8@57723|Acidobacteria,2JIAI@204432|Acidobacteriia	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	lpdA	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019464,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0036211,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045250,GO:0045252,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0097159,GO:0106077,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_1869,iEcolC_1368.EcolC_3543,iPC815.YPO3417,iSFV_1184.SFV_0107,iUMN146_1321.UM146_23385	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_407436_1	296591.Bpro_4549	3.61e-23	94.4	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,4ADXS@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_407436_2	1288494.EBAPG3_2020	5.18e-103	307.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,371SF@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_966082_1	1231391.AMZF01000014_gene2316	6.36e-127	382.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,3T1N0@506|Alcaligenaceae	28216|Betaproteobacteria	S	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_442483_1	1282876.BAOK01000002_gene944	2.47e-114	337.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TRMA@28211|Alphaproteobacteria,4BREC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_672391_1	87626.PTD2_08344	2.01e-23	95.1	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,2Q0N1@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the UPF0758 family	radC	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_672391_2	742823.HMPREF9465_01493	3.95e-33	116.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2VU1B@28216|Betaproteobacteria,4PRAN@995019|Sutterellaceae	28216|Betaproteobacteria	J	Ribosomal L28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_275801_1	671143.DAMO_2624	4e-104	325.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_116915_1	1229909.NSED_04760	1.09e-13	72.8	COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
k59_19224_1	90675.XP_010470770.1	2.43e-06	52.4	COG0589@1|root,2RZF9@2759|Eukaryota,37V17@33090|Viridiplantae,3GISS@35493|Streptophyta,3HXQG@3699|Brassicales	35493|Streptophyta	T	Universal stress protein	-	GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016208,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	-	-	-	-	-	-	-	-	-	Usp
k59_19224_2	439235.Dalk_3418	1.87e-25	103.0	COG0477@1|root,COG2814@2|Bacteria,1P2GY@1224|Proteobacteria,42MWI@68525|delta/epsilon subdivisions,2WK29@28221|Deltaproteobacteria,2MHKX@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_766467_1	570268.ANBB01000013_gene3001	9.36e-72	228.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4EG0J@85012|Streptosporangiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_966093_1	1231391.AMZF01000003_gene3116	2.55e-41	149.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
k59_966094_1	1120998.AUFC01000031_gene2277	1.14e-13	73.9	COG1961@1|root,COG1961@2|Bacteria,1TPUG@1239|Firmicutes,25B03@186801|Clostridia,3WDE6@538999|Clostridiales incertae sedis	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_867198_1	640512.BC1003_0664	8.88e-84	262.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VZNG@28216|Betaproteobacteria,1K6IW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	similarity to GP 3192745	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_116925_1	1110502.TMO_0811	1.68e-171	497.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,2JQI9@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_377215_1	258594.RPA0822	8.64e-73	236.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,3JR2Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	glutamate--cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
k59_84646_1	1454004.AW11_03720	1.21e-64	199.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2W8KR@28216|Betaproteobacteria,1KQPD@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_84646_2	1288494.EBAPG3_950	5.48e-89	289.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,372IV@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_214388_1	1229909.NSED_01615	1.74e-157	454.0	COG1032@1|root,arCOG01357@2157|Archaea,41S86@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_84658_1	864051.BurJ1DRAFT_3896	2.78e-78	241.0	COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2VKTQ@28216|Betaproteobacteria	28216|Betaproteobacteria	I	6-phosphogluconate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
k59_606499_1	298655.KI912266_gene6118	1.42e-70	227.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4EUWU@85013|Frankiales	201174|Actinobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_790077_1	519989.ECTPHS_01899	1.69e-42	151.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_790077_2	349124.Hhal_2085	0.000399	42.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_672431_1	987059.RBXJA2T_02737	1.55e-60	196.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,2VH63@28216|Betaproteobacteria,1KPE5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_766494_1	448385.sce4158	1.63e-33	128.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,430KD@68525|delta/epsilon subdivisions,2WVSS@28221|Deltaproteobacteria,2YZ09@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
k59_867221_1	314278.NB231_16478	8.76e-105	321.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_898989_1	420662.Mpe_A3116	3.98e-94	286.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,1KJUP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_116948_1	1288494.EBAPG3_22950	8.41e-67	215.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VH5N@28216|Betaproteobacteria,371SA@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Permease MlaE	mlaE_2	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_19260_1	521098.Aaci_1053	4.52e-39	146.0	COG2801@1|root,COG2801@2|Bacteria,1UINX@1239|Firmicutes,4HDMT@91061|Bacilli,27AAT@186823|Alicyclobacillaceae	91061|Bacilli	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_345203_1	1207063.P24_01520	4.06e-38	144.0	COG0583@1|root,COG0583@2|Bacteria,1MX2A@1224|Proteobacteria,2TV0H@28211|Alphaproteobacteria,2JT9Y@204441|Rhodospirillales	204441|Rhodospirillales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_149636_1	1229909.NSED_09495	6.16e-108	322.0	COG1509@1|root,arCOG03246@2157|Archaea,41SY6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_933527_1	76114.ebA2252	1.37e-223	663.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales	206389|Rhodocyclales	E	glutamate synthase	gls1	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_766514_1	1121935.AQXX01000106_gene574	1.02e-58	198.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,1XKDX@135619|Oceanospirillales	135619|Oceanospirillales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_311314_1	436308.Nmar_1383	8.07e-26	97.4	COG1460@1|root,arCOG01016@2157|Archaea,41SQ1@651137|Thaumarchaeota	651137|Thaumarchaeota	K	RNA polymerase Rpb4	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
k59_311314_2	436308.Nmar_1384	4.05e-61	188.0	COG2139@1|root,arCOG04129@2157|Archaea,41SRF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
k59_737707_1	1458275.AZ34_09710	2.55e-84	266.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,4A9R2@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	alkK	-	6.2.1.44	ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_214413_1	202698.XP_007387148.1	2.33e-07	60.8	COG2124@1|root,KOG0157@2759|Eukaryota,38BG9@33154|Opisthokonta,3Q34S@4751|Fungi,3VC4S@5204|Basidiomycota,22F79@155619|Agaricomycetes,3H8V7@355688|Agaricomycetes incertae sedis	4751|Fungi	IQ	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_997686_1	1502852.FG94_00355	4.53e-154	470.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,475WM@75682|Oxalobacteraceae	28216|Betaproteobacteria	EQ	Hydantoinase B/oxoprolinase	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_442532_1	570417.WP0358	2.26e-15	79.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,47F0K@766|Rickettsiales	766|Rickettsiales	T	response regulator containing a CheY-like receiver domain and a GGDEF domain	pleD	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
k59_509041_1	330214.NIDE2828	6.75e-29	109.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	oxpG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_899014_1	84531.JMTZ01000096_gene715	6.97e-47	168.0	COG1361@1|root,COG1361@2|Bacteria,1QVS6@1224|Proteobacteria,1S2VN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_407503_1	1117943.SFHH103_03912	2.36e-41	148.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,4B8N5@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	ugpC	-	3.6.3.20	ko:K05816	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.3	-	-	ABC_tran,TOBE_2
k59_638911_1	909663.KI867150_gene1794	9.63e-67	222.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MQD2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_244219_1	945713.IALB_2637	3.77e-45	155.0	COG0158@1|root,COG0158@2|Bacteria	2|Bacteria	G	fructose 1,6-bisphosphate 1-phosphatase activity	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iUTI89_1310.UTI89_C4836,ic_1306.c5329	FBPase
k59_244219_2	945713.IALB_2638	1.12e-85	270.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_867264_1	296587.XP_002507328.1	8.89e-24	100.0	COG0448@1|root,KOG1504@2759|Eukaryota,37Q6W@33090|Viridiplantae,34H9U@3041|Chlorophyta	3041|Chlorophyta	E	Belongs to the ATCase OTCase family	OTC1	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_867264_2	981336.F944_02142	8.27e-66	211.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,3NJA7@468|Moraxellaceae	1236|Gammaproteobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0033554,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00930,ko:K22478	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2508,iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iUTI89_1310.UTI89_C4550,iY75_1357.Y75_RS17255	AA_kinase,NAT
k59_19313_1	1380355.JNIJ01000001_gene4130	6.6e-55	189.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,3JRSQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_3
k59_442555_2	1069080.KB913028_gene897	6.38e-39	145.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,4H266@909932|Negativicutes	909932|Negativicutes	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_149684_1	1232410.KI421413_gene704	1.07e-69	232.0	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,43SCT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	7TM-HD extracellular	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_311347_1	411684.HPDFL43_21127	2.22e-110	335.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,2TSDK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_899044_1	1460635.JCM19038_3212	4.25e-09	60.8	COG0745@1|root,COG0745@2|Bacteria,1TPRU@1239|Firmicutes,4HAG0@91061|Bacilli	91061|Bacilli	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_377299_1	1382306.JNIM01000001_gene567	4.53e-13	68.6	COG0002@1|root,COG0002@2|Bacteria,2G5W0@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_377299_2	1540221.JQNI01000002_gene1263	4.32e-55	180.0	COG0548@1|root,COG0548@2|Bacteria,1WIHT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the acetylglutamate kinase family. LysZ subfamily	lysZ	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_84734_1	1089547.KB913013_gene1391	7.11e-59	199.0	COG0504@1|root,COG0504@2|Bacteria,4NEWT@976|Bacteroidetes,47KXM@768503|Cytophagia	976|Bacteroidetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_377300_1	945713.IALB_2879	2.62e-45	152.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
k59_606579_1	1123367.C666_07785	1.2e-41	148.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,2KV54@206389|Rhodocyclales	206389|Rhodocyclales	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_639579_1	365046.Rta_34020	1.04e-150	433.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VIRC@28216|Betaproteobacteria,4ACEX@80864|Comamonadaceae	28216|Betaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,SGL
k59_646919_1	557598.LHK_00365	2.85e-138	413.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,2KQ01@206351|Neisseriales	206351|Neisseriales	O	ATP-dependent Clp protease ATP-binding subunit	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_93072_1	96561.Dole_0092	3.66e-34	120.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,42VN5@68525|delta/epsilon subdivisions,2WRGG@28221|Deltaproteobacteria,2MKMJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_93072_2	1121405.dsmv_3216	1.83e-22	92.0	2ARUS@1|root,31H6C@2|Bacteria,1RFAK@1224|Proteobacteria,42RXP@68525|delta/epsilon subdivisions,2WNXF@28221|Deltaproteobacteria,2MK37@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Type I restriction enzyme R protein N terminus (HSDR_N)	-	-	-	-	-	-	-	-	-	-	-	-	HSDR_N_2
k59_614606_1	261292.Nit79A3_0240	8.99e-77	253.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,371VQ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_27388_1	648757.Rvan_3213	8.14e-53	182.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,2TZ0I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_251226_2	1121405.dsmv_2750	1e-42	152.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Starch synthase catalytic	-	-	2.4.1.21,3.2.1.1	ko:K00703,ko:K01176	ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973	M00565	R02108,R02112,R02421,R11262	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GH13,GT5	-	Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1
k59_189768_2	523791.Kkor_0154	7.65e-17	77.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1XKAV@135619|Oceanospirillales	135619|Oceanospirillales	O	redox protein, regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
k59_93080_1	1499967.BAYZ01000049_gene2749	3.63e-52	188.0	COG3405@1|root,COG4625@1|root,COG3405@2|Bacteria,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHU_C,Laminin_G_3,Malectin,PA14
k59_582782_2	1121441.AUCX01000001_gene2663	4e-18	87.8	28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,42Z58@68525|delta/epsilon subdivisions,2WTW4@28221|Deltaproteobacteria,2M8HG@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_746132_1	768671.ThimaDRAFT_2120	2.23e-70	216.0	29C7G@1|root,3163F@2|Bacteria,1QDGP@1224|Proteobacteria,1TKCK@1236|Gammaproteobacteria,1X1VP@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1005526_1	1288494.EBAPG3_4030	2.27e-85	264.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,371ZU@32003|Nitrosomonadales	28216|Betaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_941925_1	314264.ROS217_17065	2.84e-60	194.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,46R3J@74030|Roseovarius	28211|Alphaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_941925_2	1229205.BUPH_02615	2.46e-20	91.3	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria,1K5SV@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_24,rve
k59_27407_2	187272.Mlg_0745	3.75e-13	72.0	COG1051@1|root,COG4111@1|root,COG1051@2|Bacteria,COG4111@2|Bacteria,1MXHA@1224|Proteobacteria,1T1QN@1236|Gammaproteobacteria,1WYUW@135613|Chromatiales	135613|Chromatiales	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_280098_1	1408473.JHXO01000005_gene1786	7.37e-47	158.0	COG1864@1|root,COG1864@2|Bacteria,4NMN6@976|Bacteroidetes	976|Bacteroidetes	L	DNA/RNA non-specific endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS
k59_906830_1	1123368.AUIS01000031_gene1428	1.07e-65	218.0	COG0737@1|root,COG0737@2|Bacteria,1Q977@1224|Proteobacteria,1RYXZ@1236|Gammaproteobacteria,2NE5U@225057|Acidithiobacillales	1236|Gammaproteobacteria	F	5'-nucleotidase, C-terminal domain	yfkN	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_59104_1	1380394.JADL01000018_gene1922	3.55e-84	256.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2UH90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_875267_1	640081.Dsui_1978	1.39e-122	363.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,2KUM7@206389|Rhodocyclales	206389|Rhodocyclales	M	(Lipo)protein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_875267_2	265072.Mfla_0985	1.14e-96	290.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria,2KKWM@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_189799_1	595460.RRSWK_05887	1.26e-16	83.6	COG0714@1|root,COG0714@2|Bacteria,2IX1F@203682|Planctomycetes	203682|Planctomycetes	S	ATPase associated with	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_384844_1	1191523.MROS_0331	1.67e-37	145.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	-	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_614646_1	935839.JAGJ01000009_gene567	0.000218	44.3	COG2207@1|root,COG2207@2|Bacteria,2GK7Q@201174|Actinobacteria,4F5QV@85017|Promicromonosporaceae	201174|Actinobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
k59_614646_2	1288494.EBAPG3_10910	8.65e-35	122.0	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,2VUY2@28216|Betaproteobacteria,373CS@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
k59_582812_1	391038.Bphy_2359	5.89e-106	315.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_974670_1	1453501.JELR01000002_gene527	8.14e-46	166.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,464XB@72275|Alteromonadaceae	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_479478_1	1342301.JASD01000006_gene40	1.04e-24	100.0	COG4665@1|root,COG4665@2|Bacteria,1QZUS@1224|Proteobacteria,2TZVW@28211|Alphaproteobacteria,3ZZH9@60136|Sulfitobacter	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_537561_1	1123499.KB908022_gene1066	1.35e-17	84.7	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,2VJB9@28216|Betaproteobacteria,2KPYI@206351|Neisseriales	206351|Neisseriales	P	Integral membrane protein, TerC family	alx	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_537561_2	945713.IALB_1746	4.86e-50	162.0	COG1945@1|root,COG1945@2|Bacteria	2|Bacteria	I	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
k59_1005572_1	1278309.KB907100_gene2161	4.76e-34	118.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,1XKGB@135619|Oceanospirillales	135619|Oceanospirillales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_1005572_3	314278.NB231_10153	2.2e-15	72.8	2E45W@1|root,32SZG@2|Bacteria,1MZSG@1224|Proteobacteria,1S9BI@1236|Gammaproteobacteria,1WZ2A@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_251266_1	1056820.KB900638_gene66	7.73e-38	139.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,RHS,RHS_repeat
k59_157770_1	338966.Ppro_0412	7.18e-67	218.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,43THY@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
k59_614676_1	639283.Snov_0188	1.56e-96	294.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,3EYRF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_614676_2	479431.Namu_2110	1.3e-11	67.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,4ESAX@85013|Frankiales	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
k59_517469_1	1206730.BAGA01000072_gene2063	3.19e-34	129.0	COG3049@1|root,COG3049@2|Bacteria,2GK9Z@201174|Actinobacteria,4FYNZ@85025|Nocardiaceae	201174|Actinobacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
k59_681019_2	889378.Spiaf_1950	5.88e-19	84.3	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_59167_1	1049564.TevJSym_ac01310	7.28e-74	236.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1J5IR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_353380_1	420324.KI911999_gene8065	7.23e-59	196.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,1JQQ0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	PFAM Glucose Sorbosone dehydrogenase	yliI	-	1.1.5.2	ko:K00117,ko:K21430	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	GSDH
k59_414610_1	1238182.C882_0550	9.03e-95	291.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,2JR1M@204441|Rhodospirillales	204441|Rhodospirillales	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.3.1.1	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,NADH_4Fe-4S,Pyr_redox_2
k59_93173_1	251221.35213270	1.04e-13	71.6	COG3391@1|root,COG3391@2|Bacteria,1G499@1117|Cyanobacteria	1117|Cyanobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,VPEP
k59_93173_2	452637.Oter_3482	1.25e-15	77.4	COG0136@1|root,COG0136@2|Bacteria,46S74@74201|Verrucomicrobia,3K765@414999|Opitutae	414999|Opitutae	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_450480_1	1121403.AUCV01000057_gene3054	1.84e-51	183.0	COG5297@1|root,COG5297@2|Bacteria,1NDMY@1224|Proteobacteria,4333K@68525|delta/epsilon subdivisions,2WXH7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Cellulase N-terminal ig-like domain	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_4_9,CelD_N,Glyco_hydro_9
k59_251294_1	269797.Mbar_A1661	5.93e-96	291.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_479505_1	323848.Nmul_A1948	5.78e-60	189.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2VR40@28216|Betaproteobacteria,37399@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_27485_1	1216976.AX27061_2892	6.26e-10	61.2	COG2242@1|root,COG2242@2|Bacteria,1R0I9@1224|Proteobacteria,2VRVM@28216|Betaproteobacteria,3T1H7@506|Alcaligenaceae	28216|Betaproteobacteria	H	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_27485_2	1458275.AZ34_01060	4.73e-18	84.0	COG3181@1|root,COG3181@2|Bacteria,1R5RT@1224|Proteobacteria,2VJT4@28216|Betaproteobacteria,4AASU@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_614700_1	330214.NIDE3279	8.34e-138	396.0	COG3381@1|root,COG3381@2|Bacteria	2|Bacteria	S	protein complex oligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
k59_681036_1	56110.Oscil6304_4466	2.79e-78	247.0	COG5433@1|root,COG5433@2|Bacteria,1G2IT@1117|Cyanobacteria,1HHU1@1150|Oscillatoriales	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_318721_1	1283283.ATXA01000034_gene4116	4e-61	200.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,DLH,Peptidase_S9
k59_353387_1	1121937.AUHJ01000045_gene1233	5.05e-91	284.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria,468CJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_29,rve
k59_517498_1	439235.Dalk_2747	6.07e-60	209.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MIIB@213118|Desulfobacterales	28221|Deltaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1025321_1	864051.BurJ1DRAFT_2338	2.85e-91	279.0	COG3500@1|root,COG3500@2|Bacteria,1R67C@1224|Proteobacteria,2VUST@28216|Betaproteobacteria,1KMXF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
k59_93188_1	436308.Nmar_0427	4.79e-50	160.0	COG1727@1|root,arCOG00780@2157|Archaea,41SRE@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
k59_93188_2	436308.Nmar_0428	1.24e-51	169.0	COG0202@1|root,arCOG04241@2157|Archaea,41SK0@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-directed RNA polymerase, alpha subunit 40 kD subunit	-	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_A_bac,RNA_pol_L
k59_517499_1	656024.FsymDg_4236	1.13e-53	184.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,4EUI2@85013|Frankiales	201174|Actinobacteria	S	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
k59_681041_1	303518.XP_005749552.1	1.25e-56	196.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3C0YC@33208|Metazoa,3DH14@33213|Bilateria,48RUJ@7711|Chordata,49N81@7742|Vertebrata,4A97P@7898|Actinopterygii	33208|Metazoa	S	RNA-directed DNA polymerase from mobile element jockey-like	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_974736_1	509635.N824_13930	2.83e-09	56.6	COG2378@1|root,COG2378@2|Bacteria,4NHIC@976|Bacteroidetes,1IWCB@117747|Sphingobacteriia	976|Bacteroidetes	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
k59_974736_2	945713.IALB_2909	2.7e-28	112.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,CarboxypepD_reg,DUF1524,Polysacc_deac_1,SLH
k59_157809_1	690850.Desaf_1982	5.73e-66	205.0	COG2249@1|root,COG2249@2|Bacteria,1RA5X@1224|Proteobacteria,42R0Z@68525|delta/epsilon subdivisions,2WMNE@28221|Deltaproteobacteria,2MBCN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	NAD(P)H dehydrogenase (quinone)	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
k59_713789_1	1157708.KB907452_gene3980	1.13e-25	103.0	COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria,2VKBB@28216|Betaproteobacteria,4AAR0@80864|Comamonadaceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	gguB	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
k59_713789_2	743299.Acife_2323	1.71e-184	531.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_615583_1	552811.Dehly_1618	8.36e-70	223.0	COG3328@1|root,COG3328@2|Bacteria,2G6SX@200795|Chloroflexi,34DPA@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_158673_1	314278.NB231_10798	2.52e-24	100.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1S4FT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
k59_158673_2	1298863.AUEP01000005_gene2569	0.000685	43.9	COG4424@1|root,COG4424@2|Bacteria,2GMCB@201174|Actinobacteria,4DPB7@85009|Propionibacteriales	201174|Actinobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_774640_1	1198452.Jab_2c31140	5.93e-91	288.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,473A1@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain, Two-component sensor kinase N-terminal	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_774640_2	1279019.ARQK01000061_gene1711	1e-15	77.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1WW1S@135613|Chromatiales	135613|Chromatiales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_876241_1	396588.Tgr7_0108	6.7e-71	220.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1WWYM@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_538010_1	1123267.JONN01000001_gene2370	2.78e-36	132.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2TRCC@28211|Alphaproteobacteria,2K0BD@204457|Sphingomonadales	204457|Sphingomonadales	E	4-hydroxyphenylpyruvate dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
k59_126053_1	1265313.HRUBRA_01915	1.98e-111	336.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,1J4SZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_681984_1	381666.H16_A0846	1.89e-12	70.5	COG2863@1|root,COG2863@2|Bacteria,1REHS@1224|Proteobacteria,2W03N@28216|Betaproteobacteria,1K3CF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_385776_1	570967.JMLV01000008_gene1418	3.66e-38	138.0	COG0559@1|root,COG0559@2|Bacteria,1MVZ5@1224|Proteobacteria,2TRD6@28211|Alphaproteobacteria,2JPES@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_385776_2	1121920.AUAU01000008_gene1545	1.05e-28	109.0	COG0410@1|root,COG0410@2|Bacteria,3Y9ED@57723|Acidobacteria	2|Bacteria	E	ABC transporter	livF_1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_126054_1	1340493.JNIF01000003_gene1859	4.21e-31	125.0	COG4122@1|root,COG4122@2|Bacteria,3Y33U@57723|Acidobacteria	57723|Acidobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_812177_1	696747.NIES39_O04900	1.55e-75	255.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1G0YS@1117|Cyanobacteria,1H82I@1150|Oscillatoriales	1117|Cyanobacteria	O	O-linked N-acetylglucosamine transferase SPINDLY family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Sulfotransfer_2,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
k59_812177_2	981336.F944_02493	1.64e-36	130.0	COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Belongs to the N-Me-Phe pilin family	pilA	-	-	ko:K02650,ko:K02655	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
k59_812182_1	1163617.SCD_n00472	2.99e-21	89.7	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria	28216|Betaproteobacteria	K	response regulator	-	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_812182_2	379731.PST_0905	2.67e-19	91.3	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,1RPG9@1236|Gammaproteobacteria,1Z0BB@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	Histidine kinase	qseC	-	2.7.13.3	ko:K02484,ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_812193_1	395494.Galf_2006	2.24e-67	224.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,2VKG8@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1042010_1	330214.NIDE3510	6.33e-34	132.0	2DT3N@1|root,33IIR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_812269_2	1205910.B005_1469	1.06e-27	111.0	COG1131@1|root,COG1131@2|Bacteria,2IBJD@201174|Actinobacteria,4EG9B@85012|Streptosporangiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_812309_2	1006004.GBAG_0616	0.000228	43.1	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,1RN1W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
k59_1042121_2	666681.M301_2610	2.18e-39	138.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2VQ1Y@28216|Betaproteobacteria,2KMMM@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_1042132_1	1304872.JAGC01000005_gene1773	2.92e-60	191.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42R4C@68525|delta/epsilon subdivisions,2WKG9@28221|Deltaproteobacteria,2MG2B@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM LemA	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_812363_1	316067.Geob_1643	5.38e-92	296.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,43TK1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdnG-2	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_812447_1	1121927.GOHSU_14_01350	4.6e-11	62.8	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4GAD2@85026|Gordoniaceae	201174|Actinobacteria	T	Tyrosine phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
k59_1042210_1	573064.Mefer_0139	2.68e-80	250.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,23QK2@183939|Methanococci	183939|Methanococci	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	korA	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_812453_1	105559.Nwat_1289	4.1e-140	422.0	COG1452@1|root,COG1452@2|Bacteria,1QW3G@1224|Proteobacteria,1T2RD@1236|Gammaproteobacteria,1WWPC@135613|Chromatiales	135613|Chromatiales	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_812533_1	1242864.D187_008316	3.72e-112	340.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,42Q2M@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	GO:0003674,GO:0003824,GO:0004783,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016673,GO:0019419,GO:0020037,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0097159,GO:1901363	1.7.7.1,1.8.1.2,1.8.7.1	ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_3037,iECH74115_1262.ECH74115_4017,iECIAI1_1343.ECIAI1_2867,iECNA114_1301.ECNA114_2794,iECO103_1326.ECO103_3307,iECSE_1348.ECSE_3019,iECSF_1327.ECSF_2552,iECSP_1301.ECSP_3712,iECUMN_1333.ECUMN_3091,iECW_1372.ECW_m2971,iECs_1301.ECs3618,iEKO11_1354.EKO11_1005,iEcE24377_1341.EcE24377A_3065,iSFV_1184.SFV_2742,iSbBS512_1146.SbBS512_E3112,iWFL_1372.ECW_m2971,iZ_1308.Z4073	NIR_SIR,NIR_SIR_ferr
k59_1042271_1	232721.Ajs_2703	1.64e-135	416.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1042338_1	1298867.AUES01000135_gene4397	5.75e-23	103.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U1YP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
k59_812696_1	1279019.ARQK01000051_gene1372	1.13e-30	115.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_812696_2	582899.Hden_0695	7.02e-44	147.0	2AKRU@1|root,31BIQ@2|Bacteria,1Q7DM@1224|Proteobacteria,2UEKS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_812700_1	448385.sce7227	5.2e-86	263.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WMVB@28221|Deltaproteobacteria,2YUCK@29|Myxococcales	28221|Deltaproteobacteria	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_812777_1	1123392.AQWL01000004_gene2780	2.33e-28	112.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2VI6Z@28216|Betaproteobacteria,1KSZH@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_1042472_1	383372.Rcas_1863	1.03e-74	242.0	COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi,376PZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1042475_1	1237149.C900_01026	7.59e-113	331.0	COG1077@1|root,COG1077@2|Bacteria,4NETQ@976|Bacteroidetes,47JQ4@768503|Cytophagia	976|Bacteroidetes	D	TIGRFAM cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_1042526_1	395493.BegalDRAFT_3522	9.13e-29	115.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,45ZTY@72273|Thiotrichales	72273|Thiotrichales	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme	-	-	-	-	-	-	-	-	-	-	-	-	RLAN,RimK
k59_812912_1	153948.NAL212_1322	4.9e-99	294.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,371TW@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013	6.2.1.5,6.2.1.9	ko:K01902,ko:K08692	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_1042555_2	1175306.GWL_40270	2.17e-86	266.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2VH8Q@28216|Betaproteobacteria,472UC@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_1042556_1	1000565.METUNv1_03399	2.04e-60	192.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,2KVAA@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_1042584_1	1121035.AUCH01000022_gene3217	3.7e-73	233.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,2VH6J@28216|Betaproteobacteria,2KV83@206389|Rhodocyclales	206389|Rhodocyclales	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
k59_813004_1	1123514.KB905899_gene1276	1.06e-79	252.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,4607Q@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	-	-	-	-	-	-	-	-	-	-	G6PD_C,G6PD_N
k59_1042650_2	452637.Oter_4184	2.13e-08	55.1	COG1277@1|root,COG1277@2|Bacteria,46V68@74201|Verrucomicrobia,3K7QX@414999|Opitutae	414999|Opitutae	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1042652_1	555778.Hneap_1117	1.48e-89	270.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,1X00G@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM nitrate ABC transporter, ATPase subunits C and D	-	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
k59_1042666_1	720555.BATR1942_20820	2.07e-08	55.1	COG1917@1|root,COG1917@2|Bacteria,1UI65@1239|Firmicutes,4ISF6@91061|Bacilli,1ZGCF@1386|Bacillus	91061|Bacilli	S	Cupin 2, conserved barrel domain protein	ydaE	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
k59_1042666_3	45157.CMB053CT	1.88e-06	52.0	COG1070@1|root,KOG2531@2759|Eukaryota	2759|Eukaryota	G	xylulokinase activity	-	GO:0003674,GO:0003824,GO:0004856,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0005997,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	Erg28,FGGY_C,FGGY_N
k59_813109_1	1112217.PPL19_18902	7.29e-38	145.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	chemotaxis, protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_4,sCache_2
k59_813124_1	342113.DM82_5106	8.48e-57	189.0	COG1226@1|root,COG1226@2|Bacteria,1MXQP@1224|Proteobacteria,2VKI7@28216|Betaproteobacteria,1K4XJ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
k59_1042764_1	1387312.BAUS01000004_gene1491	2.58e-21	91.3	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KKB3@206350|Nitrosomonadales	206350|Nitrosomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1042764_2	1266925.JHVX01000005_gene1938	2.71e-10	60.5	COG3312@1|root,COG3312@2|Bacteria,1R3CS@1224|Proteobacteria,2WIGV@28216|Betaproteobacteria,374P5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_1042772_1	1343740.M271_35220	1.61e-54	184.0	COG0498@1|root,COG0498@2|Bacteria,2GNZD@201174|Actinobacteria	201174|Actinobacteria	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1042772_2	1424334.W822_02615	2.51e-20	89.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2W9AM@28216|Betaproteobacteria,3T71C@506|Alcaligenaceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_1042778_1	1347369.CCAD010000012_gene2395	3.94e-21	93.6	COG3191@1|root,COG3191@2|Bacteria,1TP60@1239|Firmicutes,4HD7F@91061|Bacilli,1ZME7@1386|Bacillus	91061|Bacilli	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
k59_1042778_2	883126.HMPREF9710_02354	2.66e-17	84.3	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4,Response_reg
k59_813250_1	1218084.BBJK01000104_gene6528	1.18e-47	159.0	COG3415@1|root,COG3415@2|Bacteria,1QWK4@1224|Proteobacteria,2WH2V@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_29,HTH_32
k59_1042824_1	85643.Tmz1t_1277	5.78e-167	476.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,2KVB2@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_813297_1	1122211.JMLW01000006_gene292	3.65e-18	85.1	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,1RRCA@1236|Gammaproteobacteria,1XI8F@135619|Oceanospirillales	135619|Oceanospirillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
k59_813297_2	1177179.A11A3_04355	9.15e-10	60.5	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,1S3TH@1236|Gammaproteobacteria,1XJZF@135619|Oceanospirillales	135619|Oceanospirillales	I	Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_1042833_1	1528106.JRJE01000008_gene1486	1.5e-09	60.1	2ECQ5@1|root,336MV@2|Bacteria,1N8HC@1224|Proteobacteria,2UMUN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_813402_1	888060.HMPREF9081_2605	1.14e-09	58.9	COG1473@1|root,COG1473@2|Bacteria,1TPEJ@1239|Firmicutes,4H2XC@909932|Negativicutes	909932|Negativicutes	S	amidohydrolase	iaaH	-	-	ko:K12940	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_1042925_1	1502851.FG93_01932	6.21e-06	52.4	2DPZ1@1|root,3340X@2|Bacteria,1R2EE@1224|Proteobacteria,2TZIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_228971_1	667632.KB890165_gene2255	3.27e-21	90.5	COG0583@1|root,COG0583@2|Bacteria,1MUWX@1224|Proteobacteria,2VKDH@28216|Betaproteobacteria,1K2C5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_228971_2	1121861.KB899936_gene400	5.71e-17	82.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JSUV@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_131031_1	522306.CAP2UW1_2826	1.02e-76	249.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KQAC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	SNARE associated Golgi protein	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_947317_1	59538.XP_005973337.1	5.68e-07	52.4	COG0548@1|root,KOG2436@2759|Eukaryota,394QN@33154|Opisthokonta,3BYBP@33208|Metazoa,3DFD1@33213|Bilateria	33208|Metazoa	E	Amino acid kinase family	-	-	-	-	-	-	-	-	-	-	-	-	AA_kinase
k59_947317_2	397288.C806_03506	2.25e-13	72.4	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,27J73@186928|unclassified Lachnospiraceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_751336_1	222534.KB893793_gene2435	1.02e-06	58.2	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4EUVT@85013|Frankiales	201174|Actinobacteria	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_163732_1	1110502.TMO_0588	7.9e-20	90.9	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,2JPMS@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_163732_2	693977.Deipr_0662	1.14e-17	77.4	COG2127@1|root,COG2127@2|Bacteria	2|Bacteria	T	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_653520_1	1340493.JNIF01000003_gene2670	1.72e-66	215.0	COG0592@1|root,COG0592@2|Bacteria,3Y2WE@57723|Acidobacteria	57723|Acidobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_555576_1	247633.GP2143_07499	6.78e-84	278.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_620826_1	375286.mma_0142	2.36e-38	142.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,472QG@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_33123_1	1538295.JY96_12785	1.75e-22	94.7	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2VHH3@28216|Betaproteobacteria,1KKB3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_33123_2	864051.BurJ1DRAFT_4642	1.25e-63	195.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,1KM2I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	sigma 54 modulation protein ribosomal protein S30EA	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_979960_1	945713.IALB_0604	9.85e-29	114.0	COG0433@1|root,COG1067@1|root,COG0433@2|Bacteria,COG1067@2|Bacteria	2|Bacteria	O	ATP-dependent peptidase activity	ycbZ	-	3.4.21.53	ko:K01338,ko:K04076,ko:K04770,ko:K06915	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_979960_2	945713.IALB_0605	2.23e-24	101.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_686119_1	1121413.JMKT01000008_gene1217	8.35e-80	248.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,42MU0@68525|delta/epsilon subdivisions,2WV0U@28221|Deltaproteobacteria,2MEFS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_1012398_2	305900.GV64_14985	2.91e-33	128.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XHB4@135619|Oceanospirillales	135619|Oceanospirillales	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_294322_2	2340.JV46_13480	4.12e-33	122.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1JA8U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
k59_979963_1	1266925.JHVX01000012_gene1683	1.27e-47	162.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,371SF@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_979963_2	323848.Nmul_A2242	1.12e-96	286.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2VIJ5@28216|Betaproteobacteria,3730W@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Glutathione S-transferase, N-terminal domain	yibF	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
k59_170692_1	330214.NIDE0325	9.64e-168	479.0	COG1236@1|root,COG1236@2|Bacteria,3J0FD@40117|Nitrospirae	40117|Nitrospirae	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_823875_1	472175.EL18_01317	1.48e-40	142.0	COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,2U607@28211|Alphaproteobacteria,43HEU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Alpha beta hydrolase	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
k59_823875_2	457398.HMPREF0326_00779	4.04e-09	57.4	COG1359@1|root,COG1359@2|Bacteria,1N26Y@1224|Proteobacteria,432JN@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_203198_1	595460.RRSWK_05984	3.95e-82	257.0	COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes	203682|Planctomycetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_268624_1	1459636.NTE_01536	2.68e-15	72.8	COG0652@1|root,arCOG04767@2157|Archaea,41T32@651137|Thaumarchaeota	651137|Thaumarchaeota	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_268624_2	330214.NIDE0801	7.27e-43	147.0	COG0652@1|root,COG0652@2|Bacteria,3J18H@40117|Nitrospirae	40117|Nitrospirae	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
k59_40036_1	557598.LHK_01596	1.6e-136	416.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KQDF@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdE	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
k59_986418_1	1111479.AXAR01000011_gene2827	9.78e-38	146.0	COG1199@1|root,COG1199@2|Bacteria,1TQHQ@1239|Firmicutes,4HB2Y@91061|Bacilli	91061|Bacilli	L	helicase involved in DNA repair and perhaps also replication	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,RNase_T,ResIII
k59_431470_1	1042209.HK44_007330	1.18e-109	328.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1YMXS@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	E	Cysteine desulfurase	sufS	-	2.8.1.7,4.4.1.16	ko:K01766,ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SufE
k59_660686_1	765911.Thivi_0796	5.94e-86	285.0	COG4262@1|root,COG4262@2|Bacteria,1RFZS@1224|Proteobacteria,1S1NP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_300746_1	1112274.KI911560_gene406	5.11e-83	260.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,2VKWX@28216|Betaproteobacteria,2KKSH@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_785918_1	933262.AXAM01000193_gene3044	3.76e-107	319.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MIDP@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase for insertion sequences IS1326 IS1353 (IS21 IS408 IS1162 family protein)	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_40051_2	1265502.KB905940_gene2999	2.96e-56	194.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,4AAYN@80864|Comamonadaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase NAD-binding	fadB	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_986432_1	1235457.C404_09775	5.59e-16	78.2	COG0566@1|root,COG0566@2|Bacteria,1R9JA@1224|Proteobacteria,2VQDG@28216|Betaproteobacteria,1K1SI@119060|Burkholderiaceae	28216|Betaproteobacteria	J	trna rrna methyltransferase	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
k59_986432_2	314285.KT71_18981	2.64e-11	62.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1SKRN@1236|Gammaproteobacteria,1J9GM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	-	-	-	-	-	-	-	-	-	-	RNase_HII
k59_823905_1	945713.IALB_2659	4.29e-66	217.0	COG3203@1|root,COG3203@2|Bacteria	2|Bacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
k59_855970_1	986075.CathTA2_0901	2.76e-32	128.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli	91061|Bacilli	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_431493_1	880073.Calab_3538	1.49e-91	294.0	COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_366234_1	1284679.HMPREF1626_10185	5.24e-09	60.8	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4D3BN@85005|Actinomycetales	201174|Actinobacteria	T	Response regulator receiver domain protein	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
k59_73017_1	945713.IALB_0147	3.91e-82	267.0	COG2234@1|root,COG4412@1|root,COG2234@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.4.11.10,3.4.21.50	ko:K01337,ko:K05994,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF4968,DUF5110,F5_F8_type_C,Glyco_hydro_31,PA,Peptidase_M28,Peptidase_M6,Peptidase_S8,W_rich_C
k59_497471_1	269797.Mbar_A1661	6.86e-75	238.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_300779_1	485913.Krac_9327	1.04e-97	303.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_921851_1	1121937.AUHJ01000049_gene1436	3.99e-108	327.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RMVE@1236|Gammaproteobacteria,46CKT@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Molybdopterin oxidoreductase	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	FAD_binding_6,Fer2,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NAD_binding_1
k59_203249_1	323848.Nmul_A2456	6.15e-181	525.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,371R0@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_888312_1	945713.IALB_3087	3.91e-106	316.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_14,LAM_C,Radical_SAM
k59_268675_1	543632.JOJL01000113_gene8438	6.72e-63	210.0	COG1321@1|root,COG1321@2|Bacteria,2GN2R@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_627672_1	436308.Nmar_1012	1.67e-15	73.2	COG0589@1|root,arCOG02053@2157|Archaea,41T8H@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_627672_2	215803.DB30_2443	1.3e-09	59.3	COG2885@1|root,COG4932@1|root,COG2885@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria	1224|Proteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
k59_756813_1	420662.Mpe_A1248	4.57e-43	157.0	COG4585@1|root,COG4585@2|Bacteria,1R8DN@1224|Proteobacteria,2VPJ9@28216|Betaproteobacteria,1KKHD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_7643_1	1249627.D779_3094	1.35e-92	279.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1WXIF@135613|Chromatiales	135613|Chromatiales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_73047_1	935548.KI912159_gene4473	4.06e-76	242.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,43J3F@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
k59_268687_1	62928.azo3314	4.44e-57	182.0	2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,2VRS4@28216|Betaproteobacteria,2KWF5@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF3833)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3833
k59_268687_2	243365.CV_3227	4.5e-14	72.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,2VH63@28216|Betaproteobacteria,2KQP2@206351|Neisseriales	206351|Neisseriales	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_7648_1	396588.Tgr7_1160	1.97e-72	227.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1WXRN@135613|Chromatiales	135613|Chromatiales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_562718_1	204773.HEAR2601	8.48e-107	317.0	COG0516@1|root,COG0516@2|Bacteria,1MUJM@1224|Proteobacteria,2VJMM@28216|Betaproteobacteria,473ZI@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides	guaC	-	1.7.1.7	ko:K00364	ko00230,map00230	-	R01134	RC00457	ko00000,ko00001,ko01000	-	-	-	IMPDH
k59_660750_1	1123393.KB891317_gene2207	4.36e-110	326.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2VQ9J@28216|Betaproteobacteria,1KSDQ@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_563663_1	1095769.CAHF01000011_gene2398	1.27e-111	332.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,472E5@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_334823_1	288000.BBta_5745	8.29e-09	60.5	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria,3JUY5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	MA20_38050	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_367233_1	1485544.JQKP01000001_gene887	7.11e-93	283.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,44V7E@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_301669_1	640081.Dsui_1955	4.61e-60	192.0	COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,2VISP@28216|Betaproteobacteria,2KV43@206389|Rhodocyclales	206389|Rhodocyclales	L	3'-5' exonuclease related to the exonuclease domain of PolB	-	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
k59_301669_2	1163617.SCD_n01044	2.77e-80	245.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_889189_1	1144275.COCOR_00798	1.66e-87	276.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria,2Z30F@29|Myxococcales	28221|Deltaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_398721_1	172045.KS04_22135	1.72e-60	199.0	COG0126@1|root,COG0126@2|Bacteria,4NFW2@976|Bacteroidetes,1HX73@117743|Flavobacteriia,34Q1J@308865|Elizabethkingia	976|Bacteroidetes	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_463862_1	762376.AXYL_03703	1.84e-11	65.5	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria	1224|Proteobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_463862_2	948106.AWZT01000090_gene1097	1.34e-23	96.7	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VQAE@28216|Betaproteobacteria,1K8M5@119060|Burkholderiaceae	28216|Betaproteobacteria	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_922861_1	118005.AWNK01000011_gene145	8.56e-98	301.0	COG0581@1|root,COG0581@2|Bacteria	2|Bacteria	P	inorganic phosphate transmembrane transporter activity	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_269620_1	582744.Msip34_0660	4.81e-113	341.0	COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,2VJ0K@28216|Betaproteobacteria,2KKKC@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Belongs to the peptidase M17 family	-	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
k59_301684_1	1120999.JONM01000024_gene3109	1.57e-18	87.8	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2VI7W@28216|Betaproteobacteria,2KSDN@206351|Neisseriales	206351|Neisseriales	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_74060_2	991905.SL003B_0442	1.14e-25	102.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2TS0J@28211|Alphaproteobacteria,4BPZJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC transporter	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_301688_1	877415.JNJQ01000005_gene1285	2.03e-88	269.0	COG1028@1|root,COG1028@2|Bacteria,1TRYD@1239|Firmicutes,3VQ2H@526524|Erysipelotrichia	526524|Erysipelotrichia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_661732_1	1163617.SCD_n01186	1e-89	278.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,2VKSN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_41077_1	948106.AWZT01000050_gene2089	2.59e-58	195.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,1K289@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_41077_2	983917.RGE_21280	3.17e-99	304.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VKSM@28216|Betaproteobacteria,1KNEK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	frdA	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_786245_1	1565129.JSFF01000002_gene3511	3.12e-55	179.0	COG1280@1|root,COG1280@2|Bacteria,1RFU5@1224|Proteobacteria,1S7ES@1236|Gammaproteobacteria,2QDCW@267890|Shewanellaceae	1236|Gammaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_139160_2	1219035.NT2_08_01240	8.96e-20	86.7	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_204207_1	882378.RBRH_03143	4.8e-37	128.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2VRIB@28216|Betaproteobacteria,1K4HB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_757684_1	324057.Pjdr2_2896	3.08e-08	58.9	COG0500@1|root,COG2226@2|Bacteria,1UYID@1239|Firmicutes,4HAJE@91061|Bacilli,26UBK@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_824988_1	545276.KB898729_gene1627	1.5e-78	242.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WWV1@135613|Chromatiales	135613|Chromatiales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_8702_1	1000565.METUNv1_02357	1.96e-111	335.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI5E@28216|Betaproteobacteria,2KUQW@206389|Rhodocyclales	206389|Rhodocyclales	P	nitrite transporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_334864_1	667014.Thein_0268	4.42e-29	121.0	COG2982@1|root,COG2982@2|Bacteria,2GHIX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA,AsmA_1,DUF3971
k59_889224_1	29581.BW37_01808	2.38e-47	162.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,47249@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_463895_1	1144342.PMI40_01840	2.1e-133	395.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,475AU@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K14392	-	-	-	-	ko00000,ko02000	2.A.21.1	-	-	SSF
k59_563717_1	187272.Mlg_0452	2.09e-119	378.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_955397_1	1229909.NSED_03370	3.06e-173	493.0	COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota	651137|Thaumarchaeota	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_334875_1	1031711.RSPO_c02458	8.39e-92	295.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,1K0UC@119060|Burkholderiaceae	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_628696_1	767817.Desgi_1266	0.000222	47.8	COG5662@1|root,COG5662@2|Bacteria,1VKS6@1239|Firmicutes	1239|Firmicutes	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349,zf-HC2
k59_563731_1	1121405.dsmv_3567	9.27e-64	197.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,42RE3@68525|delta/epsilon subdivisions,2WPD5@28221|Deltaproteobacteria,2MK1T@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_139191_1	436308.Nmar_1794	6.94e-90	291.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
k59_112660_2	1288494.EBAPG3_13180	2.27e-12	65.9	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,372I1@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_634701_1	1265502.KB905935_gene3068	1.21e-75	228.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2VQ2J@28216|Betaproteobacteria,4ADHY@80864|Comamonadaceae	28216|Betaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_634701_2	1123367.C666_14870	1.9e-11	63.5	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2VIBN@28216|Betaproteobacteria,2KVXU@206389|Rhodocyclales	206389|Rhodocyclales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_273768_1	1123368.AUIS01000028_gene1326	4.75e-52	185.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_177899_1	289376.THEYE_A1491	9.6e-59	204.0	COG2203@1|root,COG3829@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,3J0YT@40117|Nitrospirae	40117|Nitrospirae	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9
k59_993450_1	517417.Cpar_1996	1.37e-12	67.8	COG2877@1|root,COG2877@2|Bacteria,1FDCA@1090|Chlorobi	1090|Chlorobi	H	PFAM DAHP synthetase I KDSA	-	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_993450_2	1191523.MROS_0381	2.4e-40	142.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria	2|Bacteria	M	arabinose-5-phosphate isomerase activity	kdsD	-	2.5.1.55,5.3.1.13	ko:K01627,ko:K03281,ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530,R03254	RC00435,RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	2.A.49	-	iAF987.Gmet_1278	CBS,SIS
k59_273769_1	1415756.JQMY01000001_gene901	3.55e-22	90.5	COG5477@1|root,COG5477@2|Bacteria,1N7WT@1224|Proteobacteria,2UBTZ@28211|Alphaproteobacteria,2PEHH@252301|Oceanicola	28211|Alphaproteobacteria	S	Predicted small integral membrane protein (DUF2160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2160
k59_273769_2	75379.Tint_0242	2.73e-77	246.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,1KJK1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_700882_1	864069.MicloDRAFT_00061120	3.06e-134	391.0	COG0045@1|root,COG0045@2|Bacteria,1PYM0@1224|Proteobacteria,2U4VV@28211|Alphaproteobacteria,1JXK3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	ATP citrate lyase citrate-binding	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_2,Citrate_bind
k59_80353_1	1459636.NTE_00105	5.44e-39	133.0	COG1545@1|root,arCOG01285@2157|Archaea,41SQK@651137|Thaumarchaeota	651137|Thaumarchaeota	V	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
k59_438416_3	1218084.BBJK01000034_gene3232	3.85e-12	66.2	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,1QYHB@1224|Proteobacteria,2W1S8@28216|Betaproteobacteria,1K5IY@119060|Burkholderiaceae	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE
k59_762850_1	1454004.AW11_02963	4.76e-104	310.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,1KPQV@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_929193_1	1304883.KI912532_gene1763	1.12e-52	179.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,2KUM7@206389|Rhodocyclales	206389|Rhodocyclales	M	(Lipo)protein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_668102_1	443598.AUFA01000046_gene866	5.22e-94	283.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,2TTWT@28211|Alphaproteobacteria,3JT10@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EM	Belongs to the DapA family	MA20_04665	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_668102_2	709797.CSIRO_4121	5.44e-82	248.0	COG2043@1|root,COG2043@2|Bacteria,1NR18@1224|Proteobacteria,2TVGP@28211|Alphaproteobacteria,3JU0D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised ArCR, COG2043	MA20_36865	-	-	-	-	-	-	-	-	-	-	-	DUF169
k59_733307_1	488538.SAR116_1471	4.74e-16	76.3	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_602339_1	1121405.dsmv_0226	1.98e-119	349.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MWH@68525|delta/epsilon subdivisions,2WJMZ@28221|Deltaproteobacteria,2MI1B@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM NAD dependent epimerase dehydratase family	uge	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_505730_1	760939.E5EQ11_9CAUD	8.93e-05	52.0	4QEIG@10239|Viruses,4R0E7@35237|dsDNA viruses  no RNA stage,4QTGA@28883|Caudovirales,4QJNG@10662|Myoviridae	10662|Myoviridae	S	regulation of transcription, DNA-dependent	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_146337_1	1101195.Meth11DRAFT_2427	1.26e-106	325.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2VJB1@28216|Betaproteobacteria,2KNEC@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Aromatic amino acid lyase	-	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_863935_1	1417296.U879_14575	4.45e-05	44.7	COG2005@1|root,COG2005@2|Bacteria,1P9SX@1224|Proteobacteria,2UC9Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Transcriptional regulator, ModE family	modE	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
k59_863935_2	76114.ebA3597	5.53e-72	224.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2VJQG@28216|Betaproteobacteria,2KUXA@206389|Rhodocyclales	206389|Rhodocyclales	H	Bacterial extracellular solute-binding protein	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k59_374094_1	1118235.CAJH01000010_gene686	6.69e-29	120.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5CT@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_763663_1	216594.MMAR_0937	1.18e-24	102.0	COG0154@1|root,COG0154@2|Bacteria,2GSDB@201174|Actinobacteria,239P9@1762|Mycobacteriaceae	201174|Actinobacteria	J	component of the translational apparatus. furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. the reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-glu-tRNA(Gln) catalytic activity ATP L-glutamyl-tRNA(Gln) L- glutamine ADP phosphate L-glutaminyl-tRNA(Gln) L- glutamate	gatA_1	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase,FCD
k59_469784_1	309801.trd_1930	3.98e-74	241.0	COG0366@1|root,COG0366@2|Bacteria,2G89J@200795|Chloroflexi,27XYW@189775|Thermomicrobia	189775|Thermomicrobia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_81389_1	945713.IALB_3111	2.26e-60	198.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA3	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
k59_734347_1	1121013.P873_00160	0.000119	45.8	COG4784@1|root,COG4784@2|Bacteria,1QXTD@1224|Proteobacteria,1S66C@1236|Gammaproteobacteria,1X6UJ@135614|Xanthomonadales	135614|Xanthomonadales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_341997_1	693986.MOC_0044	4.27e-49	165.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2TRGZ@28211|Alphaproteobacteria,1JQUA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	MA20_39720	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_341997_2	936136.ARRT01000006_gene5227	2.17e-33	120.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,4BEUA@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	MA20_39715	-	-	-	-	-	-	-	-	-	-	-	DUF1178
k59_994454_1	1037409.BJ6T_21680	5.63e-84	266.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,3JU44@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_962809_1	558169.AGAV01000019_gene3084	4.74e-10	63.5	COG3090@1|root,COG3090@2|Bacteria,1V3PZ@1239|Firmicutes,4HI3P@91061|Bacilli	91061|Bacilli	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_962809_2	1189612.A33Q_4240	8.24e-06	48.5	COG1593@1|root,COG1593@2|Bacteria,4NHB5@976|Bacteroidetes,47TPP@768503|Cytophagia	976|Bacteroidetes	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_274281_1	469610.HMPREF0189_01402	5.13e-87	274.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1KITM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_930243_1	1266925.JHVX01000009_gene48	1.27e-116	344.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,372GQ@32003|Nitrosomonadales	28216|Betaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_930243_2	1007105.PT7_3482	6.09e-08	53.9	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,3T1MI@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_404658_1	335283.Neut_2511	3.04e-54	185.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria,37263@32003|Nitrosomonadales	28216|Betaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_308343_1	247490.KSU1_C0704	5.8e-57	199.0	COG0841@1|root,COG0841@2|Bacteria,2IY6W@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07788	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
k59_734371_1	987059.RBXJA2T_03021	5.99e-90	280.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1KJ65@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxyl transferase domain	accB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_439424_2	358220.C380_09735	9.72e-15	71.6	2AJ1X@1|root,319K5@2|Bacteria,1RK0X@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2829)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2829
k59_832510_1	639283.Snov_0369	2.39e-83	262.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,3EYS0@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_734373_1	177437.HRM2_17260	3.11e-73	239.0	COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria,433HE@68525|delta/epsilon subdivisions,2WYHG@28221|Deltaproteobacteria,2MP7M@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Domain of unknown function (DUF4277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4277
k59_994480_1	1121930.AQXG01000005_gene640	1.14e-31	124.0	COG5002@1|root,COG5002@2|Bacteria,4NETP@976|Bacteroidetes,1IQ3E@117747|Sphingobacteriia	976|Bacteroidetes	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_113711_1	1191523.MROS_1186	3.57e-06	49.3	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrom_c3_2
k59_469816_1	1266925.JHVX01000017_gene23	5.6e-73	235.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,371QX@32003|Nitrosomonadales	28216|Betaproteobacteria	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_962836_1	265072.Mfla_0654	3.79e-35	127.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI6B@28216|Betaproteobacteria,2KKH4@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM response regulator receiver	-	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_763698_1	331635.G5S_0123	3.8e-10	60.8	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	rsbV_2	-	-	ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	Condensation,STAS,STAS_2
k59_241448_1	1232683.ADIMK_0257	3.17e-31	126.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,465N7@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_788807_1	1123504.JQKD01000013_gene1006	5.92e-77	254.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,4ABBZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_669182_1	765910.MARPU_03780	2.84e-58	184.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1WW32@135613|Chromatiales	135613|Chromatiales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_669182_2	292415.Tbd_0418	2.28e-10	58.2	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,1KRRD@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Ribosomal protein S14p/S29e	-	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_274299_1	330214.NIDE1677	6.07e-85	261.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
k59_962852_1	1079460.ATTQ01000043_gene6078	3.69e-40	146.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,4B8QI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_16069_1	518766.Rmar_1784	8.94e-37	145.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,4NFTI@976|Bacteroidetes,1FITQ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_763713_1	765913.ThidrDRAFT_4539	5.58e-49	171.0	COG3385@1|root,COG3385@2|Bacteria,1R8M9@1224|Proteobacteria,1S1W5@1236|Gammaproteobacteria,1X27E@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_113731_1	857087.Metme_1523	3.1e-50	172.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,1RR7N@1236|Gammaproteobacteria,1XGKM@135618|Methylococcales	1236|Gammaproteobacteria	L	PFAM Integrase, catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_241468_1	713586.KB900536_gene271	1.72e-61	207.0	COG2860@1|root,COG2860@2|Bacteria,1QZZF@1224|Proteobacteria,1T4CU@1236|Gammaproteobacteria,1WZUT@135613|Chromatiales	135613|Chromatiales	S	UPF0126 domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3,UPF0126
k59_962860_1	572477.Alvin_0467	8.64e-110	358.0	COG0587@1|root,COG1372@1|root,COG0587@2|Bacteria,COG1372@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_635816_1	191610.CATYP_01435	1.07e-11	70.5	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,22MB8@1653|Corynebacteriaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Glyco_hydro_3,Glyco_hydro_3_C
k59_342070_1	420324.KI912044_gene3918	1.72e-38	144.0	COG0348@1|root,COG0348@2|Bacteria,1R9JQ@1224|Proteobacteria,2U3WR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_81464_1	1282876.BAOK01000001_gene2671	1.66e-34	130.0	COG0697@1|root,COG0697@2|Bacteria,1PHRI@1224|Proteobacteria,2TUAQ@28211|Alphaproteobacteria,4BQFV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	MA20_39710	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_404711_1	1218074.BAXZ01000010_gene2602	2.02e-104	315.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VMMI@28216|Betaproteobacteria,1K422@119060|Burkholderiaceae	28216|Betaproteobacteria	S	peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
k59_994520_1	85643.Tmz1t_3694	2.26e-128	380.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,2KUA4@206389|Rhodocyclales	206389|Rhodocyclales	L	Belongs to the DNA photolyase family	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_994520_2	1500894.JQNN01000001_gene2935	1.04e-49	178.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,473JA@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Histidine kinase	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_962880_1	1235796.C815_00766	1.66e-18	86.3	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes	1239|Firmicutes	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_505839_1	1173028.ANKO01000084_gene946	5.86e-35	126.0	COG1028@1|root,COG1028@2|Bacteria,1G0IE@1117|Cyanobacteria,1H74G@1150|Oscillatoriales	1117|Cyanobacteria	IQ	with different specificities (related to short-chain alcohol	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
k59_308396_2	1461694.ATO9_13660	5.22e-17	77.8	COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,2UA5D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	IS66 Orf2 like protein	-	-	-	-	-	-	-	-	-	-	-	-	TnpB_IS66
k59_274316_1	665571.STHERM_c12790	1.88e-50	173.0	COG0438@1|root,COG0438@2|Bacteria,2J6VH@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_788821_1	1123269.NX02_04170	6.68e-102	308.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2K3IJ@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_146452_1	740709.A10D4_06896	1.61e-17	85.9	COG2234@1|root,COG2234@2|Bacteria,1MUZ7@1224|Proteobacteria,1RS0Q@1236|Gammaproteobacteria,2QF7N@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_864050_1	598467.BrE312_1219	7.33e-28	111.0	COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,1RR6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_864050_2	243365.CV_1666	2.26e-67	219.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,2KQ0X@206351|Neisseriales	206351|Neisseriales	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_505847_1	439235.Dalk_5165	4.69e-61	214.0	COG2366@1|root,COG2366@2|Bacteria,1R9UG@1224|Proteobacteria,42PRB@68525|delta/epsilon subdivisions,2WJCS@28221|Deltaproteobacteria,2MHYM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	-
k59_994534_2	62928.azo0869	2.73e-63	201.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria,2KWEB@206389|Rhodocyclales	206389|Rhodocyclales	S	periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_603405_1	267608.RSc1464	5.14e-47	160.0	COG3427@1|root,COG3427@2|Bacteria,1RHUC@1224|Proteobacteria,2VREK@28216|Betaproteobacteria,1KH81@119060|Burkholderiaceae	28216|Betaproteobacteria	S	carbon monoxide dehydrogenase	coxG	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
k59_702046_1	395494.Galf_0076	6.97e-130	401.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,44W4X@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_832596_1	335543.Sfum_0309	9.56e-75	231.0	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2MRHW@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
k59_476466_1	1239962.C943_03303	8.94e-53	178.0	28NS6@1|root,30W1R@2|Bacteria,4NXRE@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_248169_1	1121920.AUAU01000023_gene2395	5.37e-70	231.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuD	-	4.2.1.3,4.2.1.33,4.2.1.35	ko:K01681,ko:K01703,ko:K01704,ko:K17749	ko00020,ko00290,ko00400,ko00630,ko00660,ko00720,ko00966,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00400,map00630,map00660,map00720,map00966,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00432,M00535,M00740	R01324,R01325,R01900,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170,R10501	RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_186274_1	1215092.PA6_021_00100	1.15e-148	468.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_9,Response_reg
k59_710049_1	1045858.Bint_2124	1.04e-103	317.0	COG1274@1|root,COG1274@2|Bacteria,2J5BB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_349731_1	891968.Anamo_1973	5.49e-17	85.9	COG3328@1|root,COG3328@2|Bacteria,3TAQX@508458|Synergistetes	508458|Synergistetes	L	PFAM Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_55609_1	519989.ECTPHS_11370	1.12e-44	161.0	COG4191@1|root,COG4191@2|Bacteria,1MXRR@1224|Proteobacteria,1RQ1E@1236|Gammaproteobacteria,1WW44@135613|Chromatiales	135613|Chromatiales	T	nitrogen fixation negative regulator NifL	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_9
k59_579047_1	228410.NE0785	4.28e-76	246.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,371QU@32003|Nitrosomonadales	28216|Betaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_218835_1	436308.Nmar_1533	2.5e-93	281.0	COG0533@1|root,arCOG01183@2157|Archaea,41SDX@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37	kae1	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_643434_1	880073.Calab_3543	5.73e-05	45.1	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2NNXM@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,CHASE5,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,MASE2,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3
k59_643434_2	869213.JCM21142_2738	1.38e-30	122.0	COG1621@1|root,COG2755@1|root,COG4225@1|root,COG1621@2|Bacteria,COG2755@2|Bacteria,COG4225@2|Bacteria,4NH7G@976|Bacteroidetes,47N5K@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl Hydrolase Family 88	yteR_9	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88,Lipase_GDSL_2
k59_248182_1	1158292.JPOE01000005_gene371	7.11e-101	311.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_770633_1	1366050.N234_01090	2.04e-115	343.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2WEZH@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_770633_2	316058.RPB_1162	2.17e-10	60.8	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2TSAC@28211|Alphaproteobacteria,3JS55@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, middle domain	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_218843_1	1229909.NSED_09565	1.55e-07	51.6	COG4221@1|root,arCOG01265@2157|Archaea,41S66@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_218843_2	436308.Nmar_1787	1.14e-46	149.0	COG3582@1|root,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-AN1
k59_218843_3	1229909.NSED_09575	1.11e-39	132.0	arCOG08809@1|root,arCOG08809@2157|Archaea,41TAB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_218846_2	1211115.ALIQ01000056_gene2757	6.28e-90	273.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_121609_1	1120941.AUBL01000035_gene2216	4.47e-29	120.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria,4D3GY@85005|Actinomycetales	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_938283_1	246197.MXAN_4128	8.53e-75	238.0	COG2433@1|root,COG2433@2|Bacteria,1RE5Q@1224|Proteobacteria,42WSA@68525|delta/epsilon subdivisions,2WRPQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_446959_2	926569.ANT_00590	9.01e-47	152.0	COG0292@1|root,COG0292@2|Bacteria,2G6V4@200795|Chloroflexi	200795|Chloroflexi	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_476501_1	682795.AciX8_1307	1.36e-58	202.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria,2JIBZ@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter, transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_278175_1	663610.JQKO01000001_gene953	8.21e-46	150.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,3NB6F@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	structural constituent of ribosome	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_278175_2	97138.C820_00873	1.33e-27	106.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,36DP8@31979|Clostridiaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_55643_1	330214.NIDE3939	1.22e-103	315.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PilZ,Sigma54_activat
k59_446969_1	436308.Nmar_0672	2.2e-85	259.0	COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_411472_1	1366050.N234_08440	1.28e-65	207.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2VJTI@28216|Betaproteobacteria,1K3P7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	hydrogenase 4 membrane	hyfE	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_611127_1	228410.NE1398	3.62e-20	89.4	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,37236@32003|Nitrosomonadales	28216|Betaproteobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_611127_2	265072.Mfla_0413	3.71e-45	150.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2VUIW@28216|Betaproteobacteria,2KMVP@206350|Nitrosomonadales	206350|Nitrosomonadales	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
k59_677272_1	671143.DAMO_3153	2.49e-54	185.0	COG0577@1|root,COG0577@2|Bacteria,2NP20@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	salY	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
k59_970980_1	504832.OCAR_5709	6.08e-83	259.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,3JSFI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	AAA C-terminal domain	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_903402_1	997296.PB1_08202	5.92e-23	92.0	COG0713@1|root,COG0713@2|Bacteria,1V9Z8@1239|Firmicutes,4HJ9Q@91061|Bacilli,1ZGXH@1386|Bacillus	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_903402_2	330214.NIDE0230	2.3e-31	114.0	COG0839@1|root,COG0839@2|Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_871819_2	436308.Nmar_0353	3.41e-95	278.0	COG0195@1|root,arCOG01760@2157|Archaea,41SJQ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
k59_446989_1	1158292.JPOE01000002_gene1439	1.75e-95	306.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1KJ1Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_611146_1	1265313.HRUBRA_01335	1.11e-20	94.4	COG3063@1|root,COG3063@2|Bacteria,1R0M2@1224|Proteobacteria,1T4K4@1236|Gammaproteobacteria,1JC3Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8,Transglut_core
k59_89487_1	626887.J057_08481	1.53e-54	186.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,1RPNI@1236|Gammaproteobacteria,464IY@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_121649_1	644966.Tmar_0341	5.35e-55	188.0	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,25D02@186801|Clostridia	186801|Clostridia	L	integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Mu-transpos_C,rve
k59_23955_1	288000.BBta_2686	3.68e-40	145.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2TRFU@28211|Alphaproteobacteria,3JT1D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	MA20_38130	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_742495_2	1370122.JHXQ01000033_gene369	5.16e-11	67.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2TT7X@28211|Alphaproteobacteria,4BFW1@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	eutC	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_476531_1	330214.NIDE0501	3.75e-78	243.0	COG0414@1|root,COG0414@2|Bacteria,3J0KR@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_971006_2	1121405.dsmv_1571	2.6e-16	76.6	2FHTG@1|root,349KR@2|Bacteria,1P1C2@1224|Proteobacteria,4318F@68525|delta/epsilon subdivisions,2WWJT@28221|Deltaproteobacteria,2MNZ8@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_938329_1	743720.Psefu_0894	8.99e-56	183.0	COG1309@1|root,COG1309@2|Bacteria,1N659@1224|Proteobacteria,1RPXN@1236|Gammaproteobacteria,1YW91@136845|Pseudomonas putida group	1236|Gammaproteobacteria	K	transcriptional	acrR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03577	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	TetR_C_2,TetR_N
k59_840653_1	713587.THITH_01775	1.16e-124	360.0	COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	COG0209 Ribonucleotide reductase, alpha subunit	nrdJb	-	-	-	-	-	-	-	-	-	-	-	-
k59_840653_2	558884.JRGM01000138_gene890	4.66e-37	137.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_710128_1	1266925.JHVX01000008_gene356	1.18e-32	118.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2VSI6@28216|Betaproteobacteria,3738X@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_710128_3	292415.Tbd_2193	8.02e-105	315.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2VI0Q@28216|Betaproteobacteria,1KRKQ@119069|Hydrogenophilales	119069|Hydrogenophilales	H	AIR synthase related protein, N-terminal domain	-	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_770687_1	1121271.AUCM01000003_gene1700	2.9e-34	120.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	oligoketide cyclase lipid transport protein	pasT	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
k59_770687_2	37919.EP51_26975	1.49e-10	64.7	COG4292@1|root,COG4292@2|Bacteria,2IEKC@201174|Actinobacteria,4G91W@85025|Nocardiaceae	201174|Actinobacteria	S	Bacterial low temperature requirement A protein (LtrA)	ltrA	-	-	-	-	-	-	-	-	-	-	-	LtrA
k59_315442_1	1379698.RBG1_1C00001G1780	7.88e-18	80.5	COG0826@1|root,COG0826@2|Bacteria,2NS1M@2323|unclassified Bacteria	2|Bacteria	O	peptidase U32	yegQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
k59_23962_1	395495.Lcho_4267	1.2e-96	304.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,1KK3U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_349818_1	1266909.AUAG01000003_gene911	9.65e-91	273.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales	135613|Chromatiales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_55681_1	95619.PM1_0204755	1.34e-62	209.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_938335_1	457398.HMPREF0326_01615	4.26e-10	67.0	COG0526@1|root,COG0526@2|Bacteria,1QYRT@1224|Proteobacteria,42YQK@68525|delta/epsilon subdivisions,2WUCR@28221|Deltaproteobacteria,2M93J@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
k59_1002111_1	330214.NIDE1095	1.48e-144	415.0	COG0502@1|root,COG0502@2|Bacteria,3J0I9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_742516_1	1123228.AUIH01000001_gene1258	3.1e-35	123.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1XJM3@135619|Oceanospirillales	135619|Oceanospirillales	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_742516_2	83406.HDN1F_07330	4.85e-38	132.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1J65X@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0043952,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072321	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_89509_1	391165.GbCGDNIH1_1227	2.8e-19	91.3	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2TQS1@28211|Alphaproteobacteria,2JQVX@204441|Rhodospirillales	204441|Rhodospirillales	T	Signal transduction histidine kinase, nitrogen specific	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_23976_1	28444.JODQ01000002_gene4072	3.6e-10	61.6	COG0810@1|root,COG5002@1|root,COG0810@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4EHI2@85012|Streptosporangiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_23976_2	986075.CathTA2_1202	5.51e-34	128.0	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,4H9SZ@91061|Bacilli	91061|Bacilli	E	(Alanine) symporter	agcS	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_121676_1	1038860.AXAP01000017_gene2908	3.74e-43	150.0	COG0329@1|root,COG0329@2|Bacteria,1MWAH@1224|Proteobacteria,2TSXX@28211|Alphaproteobacteria,3JX92@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EM	Dihydrodipicolinate synthetase family	dapAch4	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_840672_1	378806.STAUR_3879	3.32e-34	134.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2YTW8@29|Myxococcales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_315463_1	296591.Bpro_3009	3.49e-77	245.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHZI@28216|Betaproteobacteria,4AC4M@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_677337_1	1288494.EBAPG3_12870	8.38e-96	295.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,372BT@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_971035_1	935557.ATYB01000008_gene5308	2.17e-52	185.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4BNUF@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Molybdopterin-binding domain of aldehyde dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_971035_2	977880.RALTA_B0625	4.23e-28	113.0	COG0477@1|root,COG0477@2|Bacteria,1NS3F@1224|Proteobacteria,2WGGT@28216|Betaproteobacteria,1KIE5@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
k59_121686_1	1001585.MDS_1585	7.13e-31	123.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,1RPB9@1236|Gammaproteobacteria,1YHC9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
k59_938358_1	1297863.APJF01000030_gene905	5.31e-84	261.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2TTUB@28211|Alphaproteobacteria,3JSQS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8,TAT_signal
k59_1023507_2	1510531.JQJJ01000010_gene2011	6.44e-68	219.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3JV7P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_38030	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DctM
k59_513829_2	867845.KI911784_gene2047	3.67e-48	159.0	COG0225@1|root,COG0225@2|Bacteria,2G6JK@200795|Chloroflexi,375KD@32061|Chloroflexia	32061|Chloroflexia	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_476569_1	269799.Gmet_0334	1.48e-107	323.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,42YV6@68525|delta/epsilon subdivisions,2WTK4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_476569_2	543913.D521_0425	1.29e-35	134.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_476573_1	441620.Mpop_1062	3.64e-24	107.0	COG2303@1|root,COG2303@2|Bacteria,1MUK2@1224|Proteobacteria,2U08V@28211|Alphaproteobacteria,1JTFM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM glucose-methanol-choline oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_476573_2	765911.Thivi_0434	2.09e-42	153.0	COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,1RZPU@1236|Gammaproteobacteria,1WW3K@135613|Chromatiales	135613|Chromatiales	G	PFAM Amylo-alpha-16-glucosidase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	GDE_C,GDE_N
k59_971054_1	215803.DB30_0552	1.64e-70	222.0	COG0652@1|root,COG0652@2|Bacteria,1RENS@1224|Proteobacteria,42RIB@68525|delta/epsilon subdivisions,2WINS@28221|Deltaproteobacteria,2YZ46@29|Myxococcales	28221|Deltaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
k59_750125_2	1121861.KB899939_gene3759	3.33e-39	140.0	COG4126@1|root,COG4126@2|Bacteria	2|Bacteria	E	flavin adenine dinucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
k59_978578_1	1288494.EBAPG3_2070	1.98e-125	379.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,372BV@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_878932_1	547045.NEISICOT_01491	1.78e-28	107.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria,2KR6I@206351|Neisseriales	206351|Neisseriales	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_878932_2	1207063.P24_02311	1.83e-16	78.6	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,2JQHY@204441|Rhodospirillales	204441|Rhodospirillales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_254651_1	1380355.JNIJ01000107_gene4843	1.55e-22	99.4	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,3JU44@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_254651_2	1280954.HPO_04064	8.81e-08	52.4	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TR1E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1009097_1	748280.NH8B_0219	3.65e-118	364.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KPQF@206351|Neisseriales	206351|Neisseriales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_878942_1	313603.FB2170_04590	4.44e-21	90.1	COG1218@1|root,COG1218@2|Bacteria,4NFHY@976|Bacteroidetes,1HXAV@117743|Flavobacteriia	976|Bacteroidetes	P	COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
k59_878942_2	643648.Slip_1662	2.16e-07	53.5	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42JMM@68298|Syntrophomonadaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_193565_2	1187851.A33M_0090	3.49e-41	146.0	COG1638@1|root,COG1638@2|Bacteria,1PJG1@1224|Proteobacteria,2V8IQ@28211|Alphaproteobacteria,3FEKB@34008|Rhodovulum	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_848283_1	477228.YO5_09365	2.58e-62	210.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,1RMJ0@1236|Gammaproteobacteria,1Z3NT@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Choline_sulf_C,DUF4976,Sulfatase
k59_388433_1	1211777.BN77_2526	1.55e-170	500.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,4B9AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_161420_2	247633.GP2143_16241	2.2e-33	122.0	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,1RPZ6@1236|Gammaproteobacteria,1J5T9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions	slmA	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0007049,GO:0007346,GO:0008150,GO:0009295,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010948,GO:0010974,GO:0016043,GO:0019219,GO:0019222,GO:0022402,GO:0022607,GO:0031323,GO:0031326,GO:0031333,GO:0032271,GO:0032272,GO:0032465,GO:0032466,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0043085,GO:0043087,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043547,GO:0043565,GO:0043590,GO:0044085,GO:0044087,GO:0044093,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045786,GO:0045930,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051252,GO:0051301,GO:0051302,GO:0051336,GO:0051345,GO:0051726,GO:0051782,GO:0060255,GO:0061640,GO:0065007,GO:0065009,GO:0071840,GO:0080090,GO:0090529,GO:0097159,GO:0140110,GO:1901363,GO:1901891,GO:1901892,GO:1902410,GO:1902412,GO:1902413,GO:1903047,GO:1903436,GO:1903437,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K05501	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	TetR_N
k59_128933_1	880072.Desac_1710	5.25e-57	185.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,2MRNX@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Iron/manganese superoxide dismutases, alpha-hairpin domain	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_62759_1	1095769.CAHF01000006_gene1957	6.22e-12	70.9	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	3.1.4.52	ko:K13243	-	-	R08991	RC00296	ko00000,ko01000	-	-	-	CHASE4,EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_357147_1	671143.DAMO_0297	7.37e-30	122.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
k59_878950_1	1229909.NSED_09600	5.51e-174	494.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_31207_1	633149.Bresu_1494	1.45e-34	132.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,2KG6K@204458|Caulobacterales	204458|Caulobacterales	K	Transcriptional regulator, LysR family	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_684927_1	1173264.KI913949_gene3475	3.96e-40	137.0	COG0102@1|root,COG0102@2|Bacteria,1G512@1117|Cyanobacteria,1HAJM@1150|Oscillatoriales	1117|Cyanobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_684927_2	945713.IALB_0697	6.98e-65	199.0	COG0103@1|root,COG0103@2|Bacteria	2|Bacteria	J	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_454009_1	1121440.AUMA01000002_gene2286	9.77e-58	201.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2M800@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Pyruvate phosphate dikinase, PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_910438_1	1485544.JQKP01000014_gene1862	2.08e-08	55.5	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,44V5U@713636|Nitrosomonadales	28216|Betaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_910438_2	1288494.EBAPG3_9090	7.43e-32	122.0	COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,2VKUS@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM TonB family protein	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
k59_650632_1	330214.NIDE0763	7.73e-84	256.0	COG0812@1|root,COG0812@2|Bacteria,3J0Q1@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_978622_1	330214.NIDE3074	2.13e-121	358.0	COG0541@1|root,COG0541@2|Bacteria,3J0DT@40117|Nitrospirae	40117|Nitrospirae	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_539556_1	754477.Q7C_2409	4.56e-31	113.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,460DF@72273|Thiotrichales	72273|Thiotrichales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_539556_2	545264.KB898755_gene2741	2.33e-36	125.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1WYNJ@135613|Chromatiales	135613|Chromatiales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_539556_3	1219031.BBJR01000051_gene1446	1.6e-57	181.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,4ADJT@80864|Comamonadaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_539556_4	118797.XP_007457196.1	4.59e-17	81.3	COG0096@1|root,COG0097@1|root,KOG1754@2759|Eukaryota,KOG3254@2759|Eukaryota,39WCS@33154|Opisthokonta	33154|Opisthokonta	J	rRNA binding	MRPL6	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_978624_1	305700.B447_11472	2.86e-71	235.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,2KVUW@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
k59_96965_1	639283.Snov_0680	1.48e-137	400.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,3EYAT@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	FMN-dependent alpha-hydroxy acid dehydrogenase	lldD	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_521427_1	228410.NE1756	3.03e-76	229.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2VR5Y@28216|Betaproteobacteria,3737C@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0093)	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
k59_521427_2	62928.azo3477	4.01e-20	89.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,2KV05@206389|Rhodocyclales	206389|Rhodocyclales	L	Belongs to the methyltransferase superfamily	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
k59_193597_1	335543.Sfum_1719	1.07e-23	101.0	2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MS8T@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
k59_684942_1	381764.Fnod_0749	1.25e-07	58.5	COG0420@1|root,COG0420@2|Bacteria,2GC6F@200918|Thermotogae	200918|Thermotogae	L	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
k59_225929_1	864051.BurJ1DRAFT_1206	8.82e-75	244.0	COG1028@1|root,COG3320@1|root,COG1028@2|Bacteria,COG3320@2|Bacteria,1QSHC@1224|Proteobacteria,2VKRX@28216|Betaproteobacteria,1KMYT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
k59_650659_2	1191523.MROS_1547	8.88e-39	132.0	COG0780@1|root,COG0780@2|Bacteria	2|Bacteria	G	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_978645_1	396588.Tgr7_2201	2.47e-73	232.0	COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,1SAK5@1236|Gammaproteobacteria,1X0WH@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_62800_1	1121405.dsmv_2119	1.61e-83	269.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-3	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_878994_1	1163617.SCD_n00812	3.83e-65	212.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Permease, YjgP YjgQ family	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_193621_1	1229909.NSED_03625	1.66e-62	202.0	arCOG04054@1|root,arCOG04054@2157|Archaea,41SIQ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_848351_1	1459636.NTE_00789	8.04e-105	313.0	COG1060@1|root,arCOG00656@2157|Archaea,41SEG@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Radical SAM	-	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
k59_684971_1	946483.Cenrod_1796	9.68e-43	159.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,4AA9F@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
k59_128997_1	1123072.AUDH01000002_gene2548	2.14e-76	243.0	COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2TSR4@28211|Alphaproteobacteria,2JQKI@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_225960_1	436308.Nmar_1398	1.75e-107	328.0	COG3593@1|root,arCOG03235@2157|Archaea,41SZV@651137|Thaumarchaeota	651137|Thaumarchaeota	L	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15
k59_978661_1	1340493.JNIF01000004_gene148	1.06e-51	176.0	COG4531@1|root,COG4531@2|Bacteria,3Y2X7@57723|Acidobacteria	57723|Acidobacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_879004_1	1163617.SCD_n02226	2.15e-103	305.0	COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,2VRKF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
k59_482852_1	977880.RALTA_A1308	4.29e-54	185.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,1K165@119060|Burkholderiaceae	28216|Betaproteobacteria	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_62813_1	767434.Fraau_0599	4.35e-44	156.0	COG0454@1|root,COG1947@1|root,COG0454@2|Bacteria,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1X30B@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,GHMP_kinases_C,GHMP_kinases_N
k59_777319_1	469610.HMPREF0189_00997	7.26e-96	298.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KJ0V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_161484_1	1502770.JQMG01000001_gene1838	1.45e-48	171.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KKEZ@206350|Nitrosomonadales	206350|Nitrosomonadales	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal
k59_62816_1	1463856.JOHY01000057_gene1674	4.25e-06	52.8	COG1309@1|root,COG1309@2|Bacteria,2I8DN@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_879015_1	314278.NB231_07442	1.98e-51	168.0	2E3RZ@1|root,32YPK@2|Bacteria,1NJYT@1224|Proteobacteria,1SHP1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_129008_1	1122135.KB893135_gene756	1.15e-67	219.0	COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,2TTAU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	catalyzes the formation of indole and pyruvate from tryptophan	-	-	4.1.99.2	ko:K01668	ko00350,map00350	-	R00728	RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_254743_1	1121405.dsmv_0205	1.66e-122	374.0	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MI01@213118|Desulfobacterales	28221|Deltaproteobacteria	S	metal-dependent phosphohydrolase 7TM intracellular region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_879018_1	765912.Thimo_2157	1.05e-32	129.0	COG1173@1|root,COG1173@2|Bacteria,1R4K8@1224|Proteobacteria,1SYV4@1236|Gammaproteobacteria,1X02Z@135613|Chromatiales	135613|Chromatiales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_945901_1	1033806.HTIA_2362	3.38e-24	104.0	COG1145@1|root,arCOG05128@2157|Archaea,2XY2U@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	1.12.98.4	ko:K17996	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Fer4_22
k59_31287_2	573413.Spirs_1109	3.4e-33	118.0	COG2721@1|root,COG2721@2|Bacteria,2JB1Q@203691|Spirochaetes	203691|Spirochaetes	G	SAF	-	-	4.2.1.7	ko:K16849	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	SAF
k59_31287_3	1303518.CCALI_02736	3.43e-06	48.9	COG2721@1|root,COG2721@2|Bacteria	2|Bacteria	G	sulfolactate sulfo-lyase activity	uxaA	-	4.2.1.7	ko:K01685,ko:K16849	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_718324_1	1109445.AGSX01000063_gene811	1.77e-91	280.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,1RYUT@1236|Gammaproteobacteria,1Z0FQ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Heme d1 biosynthesis protein NirF	nirF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
k59_750977_1	1430440.MGMSRv2_3902	2.01e-104	307.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria,2JVPD@204441|Rhodospirillales	204441|Rhodospirillales	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11
k59_750977_2	1485544.JQKP01000005_gene323	2.69e-25	103.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,2VK76@28216|Betaproteobacteria,44WAJ@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_226648_1	349521.HCH_05146	1.28e-61	207.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1XIWI@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_483428_1	204773.HEAR0260	9.37e-37	135.0	COG3971@1|root,COG3971@2|Bacteria,1RGHI@1224|Proteobacteria,2VRTF@28216|Betaproteobacteria,473R4@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	2-keto-4-pentenoate hydratase	mhpD	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_522318_1	6087.XP_002169711.2	6.77e-17	85.9	COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa	33208|Metazoa	H	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Chromo,rve
k59_619113_1	237368.SCABRO_01885	1.86e-07	58.9	COG0457@1|root,COG0457@2|Bacteria,2IWZ3@203682|Planctomycetes	203682|Planctomycetes	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
k59_1009847_1	981223.AIED01000032_gene3653	1.15e-51	177.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,3NK5E@468|Moraxellaceae	1236|Gammaproteobacteria	M	Belongs to the MurCDEF family	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECP_1309.ECP_0093	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1009847_2	1097668.BYI23_A022890	1.64e-29	115.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,1JZPA@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_129718_1	1112274.KI911560_gene1875	0.000304	49.3	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,2VIKY@28216|Betaproteobacteria,2KMEF@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_162206_1	330214.NIDE0861	4.57e-81	261.0	COG1657@1|root,COG1657@2|Bacteria,3J0ZD@40117|Nitrospirae	40117|Nitrospirae	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
k59_362715_1	292415.Tbd_0219	3.38e-97	313.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,1KRD1@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Domain of unknown function (DUF3400)	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_265045_1	945713.IALB_0292	1.55e-63	209.0	COG0860@1|root,COG0860@2|Bacteria	2|Bacteria	M	N-Acetylmuramoyl-L-alanine amidase	amiA	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
k59_950547_1	247634.GPB2148_178	8.33e-83	256.0	COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,1RNPN@1236|Gammaproteobacteria,1JBY4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D	ansB	GO:0003674,GO:0003824,GO:0004067,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0034641,GO:0042597,GO:0042802,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.1,3.5.1.38	ko:K01424,ko:K05597	ko00220,ko00250,ko00460,ko00471,ko01100,ko01110,ko02020,map00220,map00250,map00460,map00471,map01100,map01110,map02020	-	R00256,R00485,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_297398_1	1288494.EBAPG3_21590	9.18e-124	372.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,372VA@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_591519_1	945713.IALB_2235	2.07e-54	185.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_428054_1	1120942.AUBM01000010_gene1464	2.69e-28	117.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4D32X@85005|Actinomycetales	201174|Actinobacteria	G	Alpha amylase, catalytic domain protein	malL	-	3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459,Malt_amylase_C
k59_656960_1	1137799.GZ78_03755	8.72e-37	142.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XIWS@135619|Oceanospirillales	135619|Oceanospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_852455_1	290397.Adeh_2087	1.48e-22	101.0	COG0437@1|root,COG5557@1|root,COG0437@2|Bacteria,COG5557@2|Bacteria,1MU1B@1224|Proteobacteria,42NS2@68525|delta/epsilon subdivisions,2WMA0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fdnH	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,NrfD
k59_754090_1	1229909.NSED_01105	5.57e-74	224.0	COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM 4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_460390_1	1231391.AMZF01000110_gene917	2.55e-66	209.0	COG2084@1|root,COG2084@2|Bacteria	2|Bacteria	I	phosphogluconate dehydrogenase (decarboxylating) activity	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_460390_2	1231391.AMZF01000068_gene2178	1.85e-68	210.0	COG3435@1|root,COG3435@2|Bacteria	2|Bacteria	Q	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_820250_1	76114.ebA4819	2.73e-25	98.6	COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,2VVP0@28216|Betaproteobacteria,2KXBI@206389|Rhodocyclales	206389|Rhodocyclales	J	RNA-binding protein containing KH domain possibly ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CRS1_YhbY
k59_820250_2	1348657.M622_09825	1.32e-71	223.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2VIU9@28216|Betaproteobacteria,2KW2K@206389|Rhodocyclales	206389|Rhodocyclales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
k59_820250_3	323848.Nmul_A0483	4.18e-163	473.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,372IS@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_297419_1	945713.IALB_2784	7.87e-50	179.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	cpt	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M14,Peptidase_M6
k59_3844_1	497321.C664_18834	3.84e-65	218.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VHZ2@28216|Betaproteobacteria,2KV7V@206389|Rhodocyclales	206389|Rhodocyclales	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_493808_1	1123023.JIAI01000001_gene6533	2.03e-69	223.0	COG3384@1|root,COG3384@2|Bacteria,2GJDG@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B	-	-	-	-	-	-	-	-	-	-	-	-	LigB
k59_265089_1	1123511.KB905865_gene1823	6.78e-17	78.2	COG3666@1|root,COG3666@2|Bacteria,1VNTS@1239|Firmicutes,4H7YC@909932|Negativicutes	909932|Negativicutes	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6
k59_591550_1	1207063.P24_01650	1.33e-89	271.0	COG1177@1|root,COG1177@2|Bacteria,1MV4A@1224|Proteobacteria,2VFIM@28211|Alphaproteobacteria,2JVFQ@204441|Rhodospirillales	204441|Rhodospirillales	E	COG1177 ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
k59_656989_1	47716.JOFH01000004_gene866	1.12e-30	118.0	COG0715@1|root,COG0715@2|Bacteria,2IEVS@201174|Actinobacteria	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
k59_722171_1	864051.BurJ1DRAFT_4418	1.04e-05	46.2	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,1KJ9W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_722171_2	395495.Lcho_0528	1.04e-73	229.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,1KIUC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_918186_2	338963.Pcar_0395	1.61e-15	76.3	COG4726@1|root,COG4726@2|Bacteria,1PQMG@1224|Proteobacteria,430ZZ@68525|delta/epsilon subdivisions,2WWZF@28221|Deltaproteobacteria,43VI0@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K12286	-	-	-	-	ko00000,ko02044	-	-	-	-
k59_918186_3	1408433.JHXV01000001_gene806	3.91e-26	115.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
k59_624199_1	945713.IALB_0628	7.35e-82	263.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_657008_1	180281.CPCC7001_495	3.1e-16	85.9	COG2931@1|root,COG2931@2|Bacteria,1G7U2@1117|Cyanobacteria,22TWD@167375|Cyanobium	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k59_460414_1	768671.ThimaDRAFT_0873	5.11e-95	293.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales	135613|Chromatiales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_689686_1	204773.HEAR2693	1.62e-14	75.5	COG2867@1|root,COG2867@2|Bacteria,1QUZA@1224|Proteobacteria,2VUHS@28216|Betaproteobacteria,4750S@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_362791_1	686340.Metal_2755	7.89e-44	162.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1XE70@135618|Methylococcales	135618|Methylococcales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_36594_1	880070.Cycma_0634	1.23e-36	130.0	COG1607@1|root,COG1607@2|Bacteria,4NERA@976|Bacteroidetes,47P9H@768503|Cytophagia	976|Bacteroidetes	I	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_265128_1	1416760.AYMS01000062_gene1227	2.26e-12	70.1	COG4221@1|root,COG4221@2|Bacteria,4NE1R@976|Bacteroidetes,1HY5P@117743|Flavobacteriia,47HG7@76831|Myroides	976|Bacteroidetes	S	Enoyl-(Acyl carrier protein) reductase	ydfG	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_3887_1	1219076.N646_1166	1.75e-36	139.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1XTB9@135623|Vibrionales	135623|Vibrionales	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_199788_1	1318628.MARLIPOL_03600	2.58e-38	132.0	COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,1SDBW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	effector of murein hydrolase LrgA	-	-	-	ko:K06518	-	-	-	-	ko00000,ko02000	1.E.14.2	-	-	LrgA
k59_199788_2	85643.Tmz1t_1268	6.2e-23	94.4	COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,2KVYR@206389|Rhodocyclales	206389|Rhodocyclales	M	of murein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	LrgB
k59_852522_1	1121106.JQKB01000005_gene2227	9.97e-60	204.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1042 Acyl-CoA synthetase (NDP forming)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_36609_1	1121405.dsmv_3039	1.48e-66	218.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,42N0J@68525|delta/epsilon subdivisions,2WJFX@28221|Deltaproteobacteria,2MHNC@213118|Desulfobacterales	28221|Deltaproteobacteria	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_167204_1	1187851.A33M_0090	1.01e-75	238.0	COG1638@1|root,COG1638@2|Bacteria,1PJG1@1224|Proteobacteria,2V8IQ@28211|Alphaproteobacteria,3FEKB@34008|Rhodovulum	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_493872_1	75379.Tint_2857	1.28e-72	227.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2VJ19@28216|Betaproteobacteria,1KKHA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Belongs to the hyi family	hyi	-	5.3.1.22,5.3.1.35	ko:K01816,ko:K22131	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
k59_820320_1	1158150.KB906242_gene270	3.03e-19	88.6	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,1SDY3@1236|Gammaproteobacteria,1WZR8@135613|Chromatiales	135613|Chromatiales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD,zinc_ribbon_2
k59_428132_1	331869.BAL199_22262	4.07e-131	381.0	COG1893@1|root,COG1893@2|Bacteria,1QMH8@1224|Proteobacteria,2TSGW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_3901_1	1283300.ATXB01000001_gene392	1.59e-131	391.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_526059_1	1462527.CCDM010000005_gene4974	2.06e-24	98.6	COG1943@1|root,COG1943@2|Bacteria,1V1CM@1239|Firmicutes,4HGN6@91061|Bacilli,23MCD@182709|Oceanobacillus	91061|Bacilli	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_591609_1	202954.BBNK01000012_gene1094	9.2e-06	48.1	COG1522@1|root,COG1522@2|Bacteria,1RCWU@1224|Proteobacteria,1S2SF@1236|Gammaproteobacteria,3NKS3@468|Moraxellaceae	1236|Gammaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
k59_134613_1	945713.IALB_0015	1.39e-124	390.0	COG1197@1|root,COG1197@2|Bacteria	2|Bacteria	L	transcription-coupled nucleotide-excision repair, DNA damage recognition	mfd	-	2.4.1.129,3.4.16.4	ko:K03723,ko:K05365	ko00550,ko03420,map00550,map03420	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011,ko03400	-	GT51	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_690562_1	497321.C664_00730	3.88e-121	352.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI6B@28216|Betaproteobacteria,2KUNC@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ompR	-	-	ko:K02483,ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_690562_2	614083.AWQR01000018_gene1812	2.49e-56	195.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,4A9M8@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	risS	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,RisS_PPD
k59_461022_1	264462.Bd0656	2.18e-73	226.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,42SPM@68525|delta/epsilon subdivisions,2MTZX@213481|Bdellovibrionales,2WMYY@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	TIGRFAM channel protein, hemolysin III family	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
k59_461022_3	765910.MARPU_13785	5.19e-08	52.0	2DR3M@1|root,33A13@2|Bacteria,1NGX8@1224|Proteobacteria,1SH42@1236|Gammaproteobacteria,1WZMV@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
k59_4775_1	330214.NIDE0990	1.2e-99	305.0	COG0568@1|root,COG0568@2|Bacteria,3J0E4@40117|Nitrospirae	40117|Nitrospirae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_853342_1	945713.IALB_1373	2.97e-129	399.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	treP	-	-	ko:K07126,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,PD40,POTRA
k59_265952_1	497321.C664_11127	1.46e-36	135.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,2KW8Q@206389|Rhodocyclales	206389|Rhodocyclales	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_232604_1	765910.MARPU_16620	1.92e-74	236.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_4783_1	1163617.SCD_n01957	2.68e-191	548.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_363640_1	1232437.KL662015_gene1247	1.95e-57	200.0	COG2203@1|root,COG2204@1|root,COG3437@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ2F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,sCache_2
k59_298282_1	485915.Dret_2265	1.1e-45	159.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria,2M7QN@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_200604_1	1131814.JAFO01000001_gene975	1.4e-15	76.3	2E61I@1|root,330QS@2|Bacteria,1RADI@1224|Proteobacteria,2U5E9@28211|Alphaproteobacteria,3F1JQ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_885792_1	945713.IALB_1922	2.64e-47	166.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	hpnE	-	1.17.8.1	ko:K21677	-	-	-	-	ko00000,ko01000	-	-	-	Amino_oxidase
k59_265973_1	1298867.AUES01000014_gene4280	6.4e-09	59.7	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_232622_1	765911.Thivi_3914	5.05e-22	94.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_526458_1	1304883.KI912532_gene407	6.13e-22	89.7	COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,2KWCC@206389|Rhodocyclales	206389|Rhodocyclales	T	phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_526458_2	1163617.SCD_n02380	9.57e-42	149.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	polyphosphate kinase	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_754800_1	1538295.JY96_09900	3.84e-40	149.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1KJ0K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_951537_1	1038859.AXAU01000001_gene2757	5.08e-07	48.1	COG4274@1|root,COG4274@2|Bacteria,1RHJ3@1224|Proteobacteria,2U9XS@28211|Alphaproteobacteria,3JZUN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
k59_951537_2	1205680.CAKO01000006_gene3253	1.21e-38	134.0	COG3806@1|root,COG3806@2|Bacteria,1QZFT@1224|Proteobacteria,2TYSC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
k59_951537_3	1123504.JQKD01000002_gene3754	9.3e-10	60.8	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,4AD1S@80864|Comamonadaceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_821185_1	388051.AUFE01000008_gene1650	1.95e-36	137.0	COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,2VQ3C@28216|Betaproteobacteria,1K2G1@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_461047_1	945713.IALB_0274	2.57e-67	208.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porG	-	1.2.7.3,1.2.7.7	ko:K00177,ko:K00187	ko00020,ko00280,ko00720,ko01100,ko01120,ko01200,map00020,map00280,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197,R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_625075_1	1282356.H045_16690	2.68e-106	328.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1YMTW@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_625075_2	1000565.METUNv1_03151	3.71e-09	55.5	COG4575@1|root,COG4575@2|Bacteria,1N6X7@1224|Proteobacteria,2WFR8@28216|Betaproteobacteria,2KX05@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
k59_951539_1	548479.HMPREF0573_10367	4.04e-58	187.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4D3VU@85005|Actinomycetales	201174|Actinobacteria	F	GTP cyclohydrolase 1	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_428962_1	909613.UO65_0744	1.93e-30	123.0	COG0530@1|root,COG0530@2|Bacteria,2GP6H@201174|Actinobacteria,4E18G@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM sodium calcium exchanger	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_526464_2	713586.KB900536_gene1256	5.08e-44	155.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_461061_1	563192.HMPREF0179_05325	1.01e-26	115.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,42PPF@68525|delta/epsilon subdivisions,2WM3K@28221|Deltaproteobacteria,2MG5Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_728897_1	1266925.JHVX01000004_gene1124	4.65e-104	308.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2VIR4@28216|Betaproteobacteria,37255@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	opaA	-	3.5.5.1	ko:K01501,ko:K11206	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_76049_1	1131553.JIBI01000046_gene1600	5.69e-36	137.0	COG2855@1|root,COG2855@2|Bacteria	2|Bacteria	P	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_206063_1	287986.DV20_36090	1.54e-68	223.0	COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4DYBE@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_630582_1	391600.ABRU01000027_gene990	1.34e-76	231.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2U57X@28211|Alphaproteobacteria,2KGE5@204458|Caulobacterales	204458|Caulobacterales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_10686_1	1266925.JHVX01000006_gene2242	7.28e-106	320.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2VHXK@28216|Betaproteobacteria,371WQ@32003|Nitrosomonadales	28216|Betaproteobacteria	C	MOFRL family	ttuD2	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_336818_1	767817.Desgi_4460	2.7e-27	109.0	COG1943@1|root,COG1943@2|Bacteria,1V6R5@1239|Firmicutes,25DIV@186801|Clostridia	186801|Clostridia	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_434364_1	572544.Ilyop_0592	2.51e-10	67.0	COG0154@1|root,COG0154@2|Bacteria,3783S@32066|Fusobacteria	32066|Fusobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_500504_1	667632.KB890169_gene5035	3.55e-47	153.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,2VUAP@28216|Betaproteobacteria,1K8TQ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710,ko:K18087	ko00360,ko00621,ko01100,ko01120,ko01220,map00360,map00621,map01100,map01120,map01220	M00543,M00545	R05261,R05262,R05263,R05264,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske,Rieske_2
k59_500504_2	85643.Tmz1t_0493	4.18e-102	312.0	COG1988@1|root,COG1988@2|Bacteria,1R5QP@1224|Proteobacteria,2WFIE@28216|Betaproteobacteria,2KVF6@206389|Rhodocyclales	206389|Rhodocyclales	S	membrane-bound metal-dependent	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
k59_500504_3	864073.HFRIS_007721	1.41e-88	270.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,473WB@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Zn-dependent protease with chaperone function	-	-	-	ko:K07387	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M48
k59_206076_1	1562701.BBOF01000052_gene1541	7.52e-40	138.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,1K2AQ@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
k59_206076_2	272560.BPSL3139	6.34e-20	90.5	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,1JZTN@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_663714_1	641491.DND132_2614	9.91e-94	292.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_336822_1	1231391.AMZF01000020_gene1928	1.61e-98	298.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
k59_465570_1	330214.NIDE2475	4.79e-82	268.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	rocA	-	1.2.1.88,1.5.5.2	ko:K00294,ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512,iYO844.BSU37780	Aldedh,Pro_dh
k59_369169_1	1121937.AUHJ01000048_gene1211	1.13e-97	290.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,46ABE@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_43053_1	856793.MICA_1940	2.33e-41	150.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4BPJW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_303525_1	1121106.JQKB01000092_gene4142	9.3e-149	434.0	COG3385@1|root,COG3385@2|Bacteria,1PHKQ@1224|Proteobacteria,2VGVZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_891092_1	1123400.KB904756_gene2658	1.3e-53	181.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,460EH@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_434378_1	1179773.BN6_53990	2.98e-58	197.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria,4E013@85010|Pseudonocardiales	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_173739_3	1038859.AXAU01000008_gene2189	0.000569	41.6	COG0745@1|root,COG0745@2|Bacteria,1N9SP@1224|Proteobacteria,2U6CP@28211|Alphaproteobacteria,3JY7U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_827008_1	1401067.HMPREF0872_06795	6.41e-39	140.0	28HXV@1|root,2Z83C@2|Bacteria,1VBQ4@1239|Firmicutes,4H570@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_827008_2	585.DR95_533	0.000222	44.7	2CASK@1|root,32RRZ@2|Bacteria,1N2PW@1224|Proteobacteria,1S90E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_369173_1	395495.Lcho_3118	5.12e-180	506.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,1KJEN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium Bile acid symporter family	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_696474_2	78345.BMERY_1596	1.23e-07	53.9	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4CYTE@85004|Bifidobacteriales	201174|Actinobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_43065_1	235909.GK1970	1.4e-55	189.0	COG2768@1|root,COG2768@2|Bacteria,1TPRV@1239|Firmicutes,4HE76@91061|Bacilli,1WG7B@129337|Geobacillus	91061|Bacilli	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_957418_1	765911.Thivi_3113	2.95e-73	241.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,1S0DI@1236|Gammaproteobacteria,1X0D5@135613|Chromatiales	135613|Chromatiales	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD
k59_891102_1	269799.Gmet_1653	4.01e-77	235.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,42PJM@68525|delta/epsilon subdivisions,2WKJN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_206104_1	765911.Thivi_2230	4.42e-66	205.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1WY5Q@135613|Chromatiales	135613|Chromatiales	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
k59_206104_2	1279019.ARQK01000047_gene1050	7.71e-12	64.7	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales	135613|Chromatiales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_465585_2	10760.Y77_BPT7	3.64e-13	68.6	4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses  no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae	10744|Podoviridae	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_759398_1	1121405.dsmv_1759	1.06e-99	296.0	COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,2MI36@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	nfnB	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
k59_630623_1	583345.Mmol_2269	6.31e-51	182.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KKXA@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Neisseria PilC beta-propeller domain	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_369183_1	335543.Sfum_2600	3.32e-39	141.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,2MSJJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_924907_1	1123242.JH636434_gene4913	1.13e-101	303.0	COG0667@1|root,COG0667@2|Bacteria,2IYAG@203682|Planctomycetes	203682|Planctomycetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_924907_2	326427.Cagg_3789	2.6e-26	107.0	COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi,37599@32061|Chloroflexia	32061|Chloroflexia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_786925_1	349521.HCH_05846	9.74e-22	92.8	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1XK5V@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_786925_2	420662.Mpe_A3400	2.48e-36	136.0	COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2VMJE@28216|Betaproteobacteria,1KKQM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_630626_1	545697.HMPREF0216_00449	3.34e-29	115.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,36DHD@31979|Clostridiaceae	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
k59_828021_1	177437.HRM2_04900	1.45e-77	251.0	COG0446@1|root,COG1142@1|root,COG1251@1|root,COG2080@1|root,COG0446@2|Bacteria,COG1142@2|Bacteria,COG1251@2|Bacteria,COG2080@2|Bacteria,1MVEK@1224|Proteobacteria,42P3Z@68525|delta/epsilon subdivisions,2WKRN@28221|Deltaproteobacteria,2MJ14@213118|Desulfobacterales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer2_BFD,GCV_T,GCV_T_C,Pyr_redox_2
k59_370080_1	1121004.ATVC01000003_gene429	1.74e-127	374.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,2KSMA@206351|Neisseriales	206351|Neisseriales	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_207076_1	1121405.dsmv_3263	2.45e-141	425.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2MHQG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_760149_1	266264.Rmet_0514	1.69e-10	64.7	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VHQP@28216|Betaproteobacteria,1K3XT@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mdtA	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_760149_2	1500893.JQNB01000001_gene474	6.77e-14	71.2	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3JU@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_925874_1	290399.Arth_3458	0.000421	47.4	2E64T@1|root,330TJ@2|Bacteria,2H60Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_77090_1	366394.Smed_2700	1.48e-78	242.0	COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2TSDR@28211|Alphaproteobacteria,4B70Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	hydrolases of the HAD superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_990321_1	378806.STAUR_3903	7.28e-117	352.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6,2.3.3.15	ko:K01652,ko:K03852	ko00290,ko00430,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00430,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R05651,R08648	RC00027,RC00106,RC01192,RC02744,RC02893,RC02903,RC02909	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_631521_1	1121015.N789_11760	1.17e-51	172.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,1X5ID@135614|Xanthomonadales	135614|Xanthomonadales	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_142112_1	489825.LYNGBM3L_68250	7.63e-61	203.0	COG3385@1|root,COG3385@2|Bacteria,1G8HU@1117|Cyanobacteria,1HD8S@1150|Oscillatoriales	1117|Cyanobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_760150_1	318167.Sfri_0290	1.69e-82	265.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,2QAFC@267890|Shewanellaceae	1236|Gammaproteobacteria	P	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_77098_1	96561.Dole_1685	2.73e-12	72.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria,2MNG5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
k59_925886_1	640081.Dsui_1177	3.42e-34	127.0	COG3005@1|root,COG3005@2|Bacteria,1Q8PP@1224|Proteobacteria,2VJG5@28216|Betaproteobacteria,2KUU3@206389|Rhodocyclales	206389|Rhodocyclales	C	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
k59_599148_1	1123487.KB892867_gene892	0.0006	41.6	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KVE6@206389|Rhodocyclales	206389|Rhodocyclales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Sigma54_activat
k59_529890_1	96561.Dole_2398	3.36e-68	215.0	COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2WJS2@28221|Deltaproteobacteria,2MI5T@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
k59_304445_1	882378.RBRH_03219	1.87e-112	351.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,1K1JU@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_828037_1	1163617.SCD_n03030	3.56e-56	182.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_828037_2	1288494.EBAPG3_8020	3.39e-266	747.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,371SY@32003|Nitrosomonadales	28216|Betaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_11719_1	987059.RBXJA2T_15173	5.64e-92	277.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJU2@28216|Betaproteobacteria,1KIWQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the arginase family	rocF	-	3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7	ko:K01476,ko:K01480,ko:K12255,ko:K18459	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157,R01990	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_990337_1	762660.E5EYK1_9CAUD	1.56e-14	77.0	4QAKE@10239|Viruses,4QUP7@35237|dsDNA viruses  no RNA stage,4QPCE@28883|Caudovirales,4QI56@10662|Myoviridae	10662|Myoviridae	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_501531_1	582899.Hden_0690	3.1e-122	360.0	COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_599162_1	999541.bgla_1g03050	1.35e-83	254.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,1K0IX@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_566710_1	279714.FuraDRAFT_2524	4.38e-95	310.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_859861_1	194439.CT0986	7.56e-34	131.0	COG0004@1|root,COG0004@2|Bacteria,1FDC2@1090|Chlorobi	1090|Chlorobi	P	PFAM Rh family protein ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_925903_1	330214.NIDE2411	2.71e-23	101.0	COG0457@1|root,COG3267@1|root,COG0457@2|Bacteria,COG3267@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,OmpA
k59_44061_1	1121472.AQWN01000003_gene1558	1.72e-82	258.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,260CB@186807|Peptococcaceae	186801|Clostridia	C	glutamate synthase (NADPH), homotetrameric	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_859863_1	1144312.PMI09_02119	2.63e-50	171.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2U0B6@28211|Alphaproteobacteria,4BDJG@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_664750_1	1408254.T458_05945	0.000162	45.1	COG2801@1|root,COG2801@2|Bacteria,1V0BG@1239|Firmicutes,4IAZ3@91061|Bacilli,273EI@186822|Paenibacillaceae	91061|Bacilli	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k59_664750_2	522373.Smlt1878	1.39e-33	120.0	COG3415@1|root,COG3415@2|Bacteria,1R0QT@1224|Proteobacteria,1T4NU@1236|Gammaproteobacteria,1X8GQ@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_958444_1	1279015.KB908456_gene1634	1.61e-07	54.3	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1Y3MQ@135624|Aeromonadales	135624|Aeromonadales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_958444_2	261292.Nit79A3_0468	1.71e-123	367.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,3720Q@32003|Nitrosomonadales	28216|Betaproteobacteria	C	TrkA-N domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_11739_1	945713.IALB_0950	4.55e-116	341.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2
k59_207114_1	1210884.HG799463_gene9798	2.75e-52	171.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_Tnp_1
k59_109487_1	94624.Bpet0346	3.7e-53	177.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,3T1VH@506|Alcaligenaceae	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_174767_1	1049564.TevJSym_ad00540	1.78e-06	49.3	COG0852@1|root,COG0852@2|Bacteria,1RB4M@1224|Proteobacteria,1S3KE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_174767_2	768671.ThimaDRAFT_1749	7.78e-86	258.0	COG0377@1|root,COG0377@2|Bacteria,1Q273@1224|Proteobacteria,1S0ZH@1236|Gammaproteobacteria,1WXWF@135613|Chromatiales	135613|Chromatiales	C	PFAM NADH Ubiquinone	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_337823_1	1191523.MROS_2697	1.99e-22	93.2	COG0344@1|root,COG0344@2|Bacteria	2|Bacteria	I	acyl-phosphate glycerol-3-phosphate acyltransferase activity	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_150310_1	1129374.AJE_05936	2.15e-18	82.4	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,1SA5Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
k59_836491_1	497964.CfE428DRAFT_4766	5.48e-29	115.0	COG1039@1|root,COG1039@2|Bacteria,46UTB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_345856_1	338969.Rfer_0259	1.72e-63	215.0	COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_639550_1	1121033.AUCF01000003_gene3332	2.6e-125	367.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TUWG@28211|Alphaproteobacteria,2JQ92@204441|Rhodospirillales	204441|Rhodospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_377879_2	565045.NOR51B_1401	8.1e-34	125.0	COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,1S1F0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
k59_345857_1	713586.KB900536_gene1305	2e-82	254.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RXZ5@1236|Gammaproteobacteria,1WXP8@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_639553_1	1000565.METUNv1_02803	1.52e-45	150.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,2KWDE@206389|Rhodocyclales	206389|Rhodocyclales	H	molybdopterin-guanine dinucleotide biosynthesis protein	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
k59_639553_2	76114.ebA6677	6.82e-19	85.9	COG2308@1|root,COG2308@2|Bacteria,1P9A0@1224|Proteobacteria,2VISX@28216|Betaproteobacteria,2KU66@206389|Rhodocyclales	206389|Rhodocyclales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_85380_1	1267005.KB911264_gene3114	1.08e-49	177.0	COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria,2TT2M@28211|Alphaproteobacteria,3N8BP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_998325_1	1191523.MROS_2610	2.36e-32	127.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_311885_1	640081.Dsui_2814	2.23e-82	264.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_244769_1	1198452.Jab_2c08620	7.15e-102	323.0	COG2208@1|root,COG4252@1|root,COG2208@2|Bacteria,COG4252@2|Bacteria,1QUNZ@1224|Proteobacteria,2WEJF@28216|Betaproteobacteria	28216|Betaproteobacteria	T	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,SpoIIE
k59_509724_1	1279017.AQYJ01000025_gene494	1.25e-14	78.6	COG0583@1|root,COG0583@2|Bacteria,1R7JT@1224|Proteobacteria,1S481@1236|Gammaproteobacteria,46CVN@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_276175_2	1158150.KB906241_gene1166	9.33e-50	171.0	COG2141@1|root,COG2141@2|Bacteria,1MVRS@1224|Proteobacteria,1S0S1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_836507_1	159087.Daro_3824	3.06e-220	622.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VIE4@28216|Betaproteobacteria,2M02H@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_377899_1	1121374.KB891585_gene2315	3.17e-65	211.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_998335_1	1163617.SCD_n01160	1.99e-192	557.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Extracellular solute-binding protein	oppA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_311892_1	448385.sce6616	9.55e-23	103.0	COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_150347_1	180281.CPCC7001_2036	4.26e-14	73.6	COG0210@1|root,COG0210@2|Bacteria,1G17G@1117|Cyanobacteria,22RWZ@167375|Cyanobium	1117|Cyanobacteria	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_510665_1	216594.MMAR_4249	6.13e-35	122.0	COG2030@1|root,COG2030@2|Bacteria,2IHT0@201174|Actinobacteria,2392X@1762|Mycobacteriaceae	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_510665_2	710686.Mycsm_02067	1.5e-50	170.0	COG1960@1|root,COG1960@2|Bacteria,2GITF@201174|Actinobacteria,236CQ@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
k59_967802_1	1123239.KB898631_gene2323	2.34e-93	282.0	COG4948@1|root,COG4948@2|Bacteria,1U140@1239|Firmicutes,4HAT9@91061|Bacilli	91061|Bacilli	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
k59_183637_1	1038862.KB893856_gene853	1.62e-71	227.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2U192@28211|Alphaproteobacteria,3JUI7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_346813_1	160492.XF_1213	3.79e-57	195.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1X53V@135614|Xanthomonadales	135614|Xanthomonadales	T	gtp-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_837478_1	991905.SL003B_2630	6.12e-30	123.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_378766_2	926550.CLDAP_14930	5.18e-14	72.0	COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi	200795|Chloroflexi	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_86349_1	1193729.A1OE_755	1.8e-05	46.6	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2TR6P@28211|Alphaproteobacteria,2JR9V@204441|Rhodospirillales	204441|Rhodospirillales	P	COG1840 ABC-type Fe3 transport system, periplasmic component	futA1	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_86349_2	159087.Daro_1198	3.71e-44	158.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,2KVS9@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type Fe3 transport system, permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_706945_1	309807.SRU_0989	9.92e-29	112.0	COG2897@1|root,COG2897@2|Bacteria,4NF85@976|Bacteroidetes,1FJSZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_706945_2	309807.SRU_1123	5.88e-21	96.3	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,4NDZ9@976|Bacteroidetes,1FK12@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_151283_1	157072.XP_008870257.1	0.000103	47.8	COG0142@1|root,KOG0776@2759|Eukaryota	2759|Eukaryota	H	isoprenoid biosynthetic process	GPPS	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009536,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016740,GO:0016765,GO:0022414,GO:0032501,GO:0032502,GO:0042180,GO:0042181,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0050347,GO:0051186,GO:0051188,GO:0061458,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.1,2.5.1.82,2.5.1.83	ko:K05355,ko:K14066	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00366	R01658,R09245,R09246	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_20928_1	523791.Kkor_1727	9.65e-24	105.0	COG1629@1|root,COG4771@2|Bacteria,1RAXV@1224|Proteobacteria,1S3M5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Outer membrane receptor	-	-	-	ko:K02014,ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.2	-	-	Plug,TonB_dep_Rec
k59_640521_1	1157708.KB907452_gene3581	1.49e-33	127.0	COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,2VQS7@28216|Betaproteobacteria,4AJBG@80864|Comamonadaceae	28216|Betaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_52894_1	290397.Adeh_0845	1.52e-75	238.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,42QXC@68525|delta/epsilon subdivisions,2WN3M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	FeS assembly protein SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_767963_1	330214.NIDE1339	6.93e-119	348.0	COG0202@1|root,COG0202@2|Bacteria,3J0AR@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_378777_1	1121861.KB899915_gene1849	5.89e-95	287.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TUWV@28211|Alphaproteobacteria,2JQWC@204441|Rhodospirillales	204441|Rhodospirillales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_473959_1	67352.JODS01000012_gene4393	4.1e-24	97.8	COG1335@1|root,COG1335@2|Bacteria,2IG6Q@201174|Actinobacteria	201174|Actinobacteria	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_1021929_1	330214.NIDE4314	3.06e-49	168.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_999283_1	1159870.KB907784_gene1981	3.26e-84	258.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,3T1K5@506|Alcaligenaceae	28216|Betaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_510706_1	580332.Slit_0452	2.04e-51	175.0	COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_534238_1	156889.Mmc1_1635	5.25e-06	54.7	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_790770_1	582899.Hden_3409	7.88e-05	45.4	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,3N67K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_790770_2	316057.RPD_0567	7.81e-53	179.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,3JT1N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	D	Peptidase family M23	filA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_151305_1	228410.NE1558	1.71e-44	147.0	COG3335@1|root,COG3335@2|Bacteria,1N1J6@1224|Proteobacteria	1224|Proteobacteria	L	to AA sequence GI	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_608205_1	338969.Rfer_3094	5.63e-28	114.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,4AE6V@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_118637_2	85643.Tmz1t_1404	2.99e-93	281.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,2KUIS@206389|Rhodocyclales	206389|Rhodocyclales	P	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_118637_3	85643.Tmz1t_1403	4.22e-33	125.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KUBF@206389|Rhodocyclales	206389|Rhodocyclales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_739434_1	1056816.JAFQ01000004_gene5578	2.35e-25	100.0	2BVHN@1|root,332R2@2|Bacteria,2IPM7@201174|Actinobacteria,4G18N@85025|Nocardiaceae	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
k59_510714_1	1100720.ALKN01000007_gene3063	6e-89	268.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJRS@28216|Betaproteobacteria,4AAWC@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_575997_1	436308.Nmar_0244	6.55e-81	249.0	COG0472@1|root,arCOG03199@2157|Archaea,41S8B@651137|Thaumarchaeota	651137|Thaumarchaeota	M	glycosyl transferase family	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
k59_183681_1	338963.Pcar_2423	1.16e-57	190.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,43SW7@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_183681_2	472759.Nhal_2803	1.27e-28	106.0	COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,1WZ3B@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF1820)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1820
k59_408890_1	1230476.C207_05111	4.23e-22	95.5	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,3JUAA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	hbdA	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_312773_1	266117.Rxyl_2663	3.31e-36	141.0	COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,2I2Y1@201174|Actinobacteria,4CU6E@84995|Rubrobacteria	201174|Actinobacteria	T	PFAM response regulator receiver ATP-binding region, ATPase-like histidine kinase A-like Hpt PAS fold-3 PAS fold-4 PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg
k59_151314_1	335543.Sfum_0268	3.42e-66	214.0	COG0034@1|root,COG0034@2|Bacteria,1R7JX@1224|Proteobacteria,42MAC@68525|delta/epsilon subdivisions,2WKFD@28221|Deltaproteobacteria,2MQ6P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Glutamine amidotransferase domain	-	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7
k59_378801_1	313606.M23134_04333	2.36e-14	71.6	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_183689_1	318424.EU78_29015	8.86e-100	300.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,233KU@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_151321_1	1125973.JNLC01000010_gene1773	4.96e-87	263.0	COG1809@1|root,COG1809@2|Bacteria,1MUQY@1224|Proteobacteria,2U1YM@28211|Alphaproteobacteria,3JXWR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	(2R)-phospho-3-sulfolactate synthase (ComA)	-	-	-	-	-	-	-	-	-	-	-	-	ComA
k59_86407_1	997830.HMPREF1124_1436	3.86e-12	72.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4HA1D@91061|Bacilli,43F4I@68892|Streptococcus infantis	91061|Bacilli	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_312786_1	264198.Reut_A3412	2.22e-118	365.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K0Y7@119060|Burkholderiaceae	28216|Betaproteobacteria	L	dna topoisomerase III	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
k59_312786_2	580332.Slit_0006	2.11e-05	45.8	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,44VI9@713636|Nitrosomonadales	28216|Betaproteobacteria	L	DNA recombination-mediator protein A	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_183696_1	1121405.dsmv_0343	3.75e-171	489.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2MI2A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528	Seryl_tRNA_N,tRNA-synt_2b
k59_378823_1	96561.Dole_1364	7.96e-21	95.5	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI07@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_608241_1	1163617.SCD_n01992	1.84e-101	308.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_408912_1	1235457.C404_10055	4.27e-27	107.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,1K1XI@119060|Burkholderiaceae	28216|Betaproteobacteria	O	XdhC and CoxI family	coxI	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_408912_2	266265.Bxe_A4351	6.38e-14	68.2	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ75@28216|Betaproteobacteria,1K1AG@119060|Burkholderiaceae	28216|Betaproteobacteria	C	carbon monoxide dehydrogenase	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_21002_1	1454004.AW11_02297	1.05e-34	126.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,1KQ0R@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_21002_2	1122212.AULO01000007_gene2308	0.000316	43.5	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1XJYV@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_474007_1	562970.Btus_2762	8.63e-37	139.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli,279NT@186823|Alicyclobacillaceae	91061|Bacilli	E	Peptidase dimerisation domain	dapE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_944350_1	2340.JV46_05690	2.44e-226	629.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_192177_2	1392838.AWNM01000008_gene1403	2.34e-39	142.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2VIZR@28216|Betaproteobacteria,3T54I@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.338	ko:K16844	ko00270,ko01120,map00270,map01120	-	R07137	RC00031	ko00000,ko00001,ko01000	-	-	-	Ldh_2
k59_944360_1	28532.XP_010553978.1	5.86e-48	162.0	COG0120@1|root,KOG3075@2759|Eukaryota,37KM9@33090|Viridiplantae,3GB4J@35493|Streptophyta,3HRBA@3699|Brassicales	35493|Streptophyta	G	ribose-5-phosphate isomerase	-	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0007275,GO:0008150,GO:0008219,GO:0009791,GO:0009987,GO:0010228,GO:0016853,GO:0016860,GO:0016861,GO:0022414,GO:0032501,GO:0032502,GO:0044424,GO:0044464,GO:0048608,GO:0048731,GO:0048856,GO:0061458	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_453615_1	237368.SCABRO_00086	3.13e-78	243.0	COG2887@1|root,COG2887@2|Bacteria	2|Bacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	3.6.4.12	ko:K10742	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	AAA_24,PDDEXK_1
k59_453620_1	613026.HRAG_01005	1.49e-09	61.2	COG1825@1|root,COG1825@2|Bacteria,1NC57@1224|Proteobacteria,42TM3@68525|delta/epsilon subdivisions,2YPAA@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_356764_1	1303518.CCALI_00336	1.07e-32	130.0	COG1022@1|root,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_254323_1	1121405.dsmv_0655	3.06e-106	313.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,42MX4@68525|delta/epsilon subdivisions,2WKVB@28221|Deltaproteobacteria,2MHKN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ATPase associated with various cellular activities AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_388013_1	1297863.APJF01000026_gene3694	1.44e-40	142.0	28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,2TSDQ@28211|Alphaproteobacteria,3JWGM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
k59_749724_1	640081.Dsui_0657	7.92e-29	119.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales	206389|Rhodocyclales	NT	Methyl-accepting chemotaxis protein	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_650244_1	1500893.JQNB01000001_gene2243	6.15e-18	82.8	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1X3ZX@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_453628_1	945713.IALB_0035	5.11e-152	451.0	COG0013@1|root,COG0013@2|Bacteria	2|Bacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1008772_1	706587.Desti_2503	2.48e-73	244.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MRGT@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_586368_2	945713.IALB_0506	3.69e-85	255.0	COG2109@1|root,COG2109@2|Bacteria	2|Bacteria	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
k59_225545_1	1178540.BA70_18640	1.76e-05	46.6	COG1396@1|root,COG1396@2|Bacteria,1UV6T@1239|Firmicutes,4I1D1@91061|Bacilli	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
k59_910057_1	945713.IALB_0644	7.48e-11	62.4	COG1185@1|root,COG1185@2|Bacteria	2|Bacteria	J	polyribonucleotide nucleotidyltransferase activity	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_910057_2	945713.IALB_0645	3.17e-41	147.0	COG1530@1|root,COG1530@2|Bacteria	2|Bacteria	J	ribonuclease E activity	rng	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_356782_1	748280.NH8B_0649	1.74e-39	150.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KPJR@206351|Neisseriales	206351|Neisseriales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_520959_1	1229909.NSED_03355	1.37e-67	231.0	COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota	651137|Thaumarchaeota	D	SMC proteins Flexible Hinge Domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_161075_1	153948.NAL212_2118	4.68e-34	126.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,371UG@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_161075_2	265072.Mfla_2380	2.39e-78	241.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VJYW@28216|Betaproteobacteria,2KKB8@206350|Nitrosomonadales	206350|Nitrosomonadales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_128534_1	768670.Calni_0482	1.1e-116	351.0	COG4147@1|root,COG4147@2|Bacteria,2GFB9@200930|Deferribacteres	200930|Deferribacteres	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_96586_1	420662.Mpe_A2001	2.49e-13	70.5	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,1KIXP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_96586_2	1278309.KB907101_gene381	1.7e-30	127.0	COG0457@1|root,COG0457@2|Bacteria,1R9GZ@1224|Proteobacteria,1RZID@1236|Gammaproteobacteria,1XKTX@135619|Oceanospirillales	135619|Oceanospirillales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF560,TPR_19
k59_161076_1	945713.IALB_3198	3.21e-68	221.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_161076_2	1279009.ADICEAN_00044	1.99e-16	77.4	COG3832@1|root,COG3832@2|Bacteria,4NQ4A@976|Bacteroidetes,47QHI@768503|Cytophagia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_453647_1	1131553.JIBI01000046_gene1600	7.58e-78	249.0	COG2855@1|root,COG2855@2|Bacteria	2|Bacteria	P	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_356790_1	1502852.FG94_00625	1.63e-54	194.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VJEX@28216|Betaproteobacteria,476HV@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Neisseria PilC beta-propeller domain	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_321734_1	977880.RALTA_A2741	1.33e-39	144.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6T9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_878604_1	477184.KYC_22871	1.67e-44	158.0	COG1146@1|root,COG1146@2|Bacteria,1MU2I@1224|Proteobacteria,2VJHI@28216|Betaproteobacteria,3T21S@506|Alcaligenaceae	28216|Betaproteobacteria	C	utilization protein B	citB	-	-	ko:K13795	-	-	-	-	ko00000	-	-	-	-
k59_878604_2	998674.ATTE01000001_gene3925	2.69e-13	68.9	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,1RN0D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	required for the utilization of tricarballylate as a carbon and energy source by S. enterica	cobZ	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_1008803_1	543913.D521_0390	1.87e-41	148.0	COG0589@1|root,COG0861@1|root,COG0589@2|Bacteria,COG0861@2|Bacteria,1MXSK@1224|Proteobacteria,2VHZ5@28216|Betaproteobacteria,1KQ0Z@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_356800_1	187272.Mlg_2565	2.05e-33	125.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1WXUX@135613|Chromatiales	135613|Chromatiales	I	6-phosphogluconate dehydrogenase, NAD-binding	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_128553_1	644968.DFW101_1367	4.84e-79	246.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2M7UU@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_1008805_1	1540257.JQMW01000011_gene1984	1.2e-34	127.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,36EIH@31979|Clostridiaceae	186801|Clostridia	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1008805_2	1288484.APCS01000029_gene2270	4.24e-11	61.6	COG1950@1|root,COG1950@2|Bacteria,1WK5E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_650279_1	28444.JODQ01000003_gene4689	8.04e-28	110.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4EH1N@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA thioesterase	tesB	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
k59_482483_1	366394.Smed_5200	2.75e-40	146.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,2TTM8@28211|Alphaproteobacteria,4B7YE@82115|Rhizobiaceae	28211|Alphaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
k59_254359_1	948106.AWZT01000001_gene5477	2.15e-61	196.0	COG0546@1|root,COG0546@2|Bacteria,1QEY0@1224|Proteobacteria,2VJ8N@28216|Betaproteobacteria,1K1RZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_254359_2	990285.RGCCGE502_14149	2.63e-36	136.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,4B9N7@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_193245_1	1278309.KB907107_gene1650	1.36e-29	122.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1XHEA@135619|Oceanospirillales	135619|Oceanospirillales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_225580_1	666681.M301_1169	8.41e-105	316.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,2KMDA@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_717196_1	257310.BB4237	1.9e-33	129.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,3T1DK@506|Alcaligenaceae	28216|Betaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_225582_1	1235457.C404_16690	1.61e-16	75.5	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,2VTYC@28216|Betaproteobacteria,1K761@119060|Burkholderiaceae	28216|Betaproteobacteria	L	dna polymerase III (Chi subunit)	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_717199_1	580332.Slit_2429	6.3e-35	126.0	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,2VU5M@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
k59_776937_1	1123072.AUDH01000005_gene1646	1.27e-27	114.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,2JTNS@204441|Rhodospirillales	204441|Rhodospirillales	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_776937_2	1469245.JFBG01000037_gene1851	1.1e-79	241.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,1S43F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	dehydratase	-	-	4.2.1.56	ko:K18290	ko00660,map00660	-	R02491	RC00730	ko00000,ko00001,ko01000	-	-	-	MaoC_dehydratas
k59_776937_3	941449.dsx2_2282	1.67e-09	63.2	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,43B63@68525|delta/epsilon subdivisions,2X6JM@28221|Deltaproteobacteria,2MH3V@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_388073_1	671143.DAMO_2645	2.89e-35	137.0	COG0751@1|root,COG0751@2|Bacteria,2NNWY@2323|unclassified Bacteria	2|Bacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	DALR_1,tRNA_synt_2f
k59_586420_1	1265505.ATUG01000002_gene2041	1.95e-44	149.0	COG3807@1|root,COG3807@2|Bacteria,1RIYJ@1224|Proteobacteria,42SNK@68525|delta/epsilon subdivisions,2WPNS@28221|Deltaproteobacteria,2MK8E@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_4
k59_684565_1	880072.Desac_2730	7.54e-24	99.8	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitrate reductase gamma subunit	dsrM	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
k59_684565_2	1009370.ALO_03901	1.8e-28	114.0	COG0247@1|root,COG0247@2|Bacteria,1TSC1@1239|Firmicutes,4H6UU@909932|Negativicutes	909932|Negativicutes	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_8
k59_650294_1	1004785.AMBLS11_18510	2e-85	270.0	COG3420@1|root,COG3420@2|Bacteria,1NNDG@1224|Proteobacteria,1SZ6G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
k59_1008825_1	292415.Tbd_0614	2.38e-25	104.0	COG0438@1|root,COG0438@2|Bacteria,1RB3J@1224|Proteobacteria,2VJNY@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_1008825_2	1210884.HG799474_gene15174	9.38e-28	107.0	COG0730@1|root,COG0730@2|Bacteria,2J37C@203682|Planctomycetes	203682|Planctomycetes	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
k59_650296_1	292415.Tbd_2473	5.86e-103	313.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria,1KRQV@119069|Hydrogenophilales	119069|Hydrogenophilales	H	CobB/CobQ-like glutamine amidotransferase domain	-	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,GATase_3
k59_1027116_1	1293054.HSACCH_00116	1.53e-06	48.5	COG0857@1|root,COG0857@2|Bacteria,1VEWN@1239|Firmicutes,24QW9@186801|Clostridia,3WCBD@53433|Halanaerobiales	186801|Clostridia	C	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
k59_1027116_2	177437.HRM2_16550	3.16e-21	97.1	COG1145@1|root,COG2000@1|root,COG4624@1|root,COG1145@2|Bacteria,COG2000@2|Bacteria,COG4624@2|Bacteria,1N8C8@1224|Proteobacteria,42WQ6@68525|delta/epsilon subdivisions,2WRHJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4
k59_945485_1	1453501.JELR01000001_gene2738	3.94e-17	80.5	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,4673B@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
k59_356829_1	329726.AM1_6086	6.63e-30	123.0	COG2909@1|root,COG2909@2|Bacteria,1G3UH@1117|Cyanobacteria	1117|Cyanobacteria	K	ATP-dependent transcriptional regulator	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_128581_1	1163617.SCD_n01752	3.68e-90	273.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Pfam Glycosyl transferase family 2	arnC	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
k59_618026_1	557598.LHK_01412	1.71e-32	124.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,2KQ63@206351|Neisseriales	206351|Neisseriales	S	overlaps another CDS with the same product name	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_978289_1	1235457.C404_08975	2.22e-40	144.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,1K0KZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM AFG1-family ATPase	yhcM	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
k59_978289_2	1095769.CAHF01000011_gene2418	7.86e-15	73.6	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,4734P@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	odhL	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_161119_1	1038869.AXAN01000070_gene706	5.41e-40	141.0	COG1309@1|root,COG1309@2|Bacteria,1N014@1224|Proteobacteria,2VVAF@28216|Betaproteobacteria,1K44V@119060|Burkholderiaceae	28216|Betaproteobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_945490_1	75379.Tint_1419	2.37e-142	414.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,1KJNG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	glutamine synthetase	glnA	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360	5.4.4.3,6.3.1.2	ko:K01915,ko:K20712	ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253,R06988,R09284	RC00010,RC01754,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_417692_1	1123487.KB892834_gene2921	3.66e-80	250.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VI2K@28216|Betaproteobacteria,2KYAB@206389|Rhodocyclales	206389|Rhodocyclales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_650306_1	582744.Msip34_1399	3.22e-85	261.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,2KM0C@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_650306_2	1288494.EBAPG3_700	3.37e-62	194.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2VRKQ@28216|Betaproteobacteria,37315@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_749813_1	436308.Nmar_1225	5.47e-105	309.0	COG0109@1|root,arCOG00479@2157|Archaea,41SDQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_321788_1	1499967.BAYZ01000025_gene290	3.85e-94	288.0	COG2358@1|root,COG2358@2|Bacteria	2|Bacteria	G	TRAP transporter, solute receptor (TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_794692_1	1459636.NTE_00263	3.73e-31	115.0	arCOG00516@1|root,arCOG00516@2157|Archaea,41T43@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_1008850_1	697282.Mettu_3507	6.29e-139	402.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1XEJ2@135618|Methylococcales	135618|Methylococcales	M	epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_388118_1	59538.XP_005973521.1	1.57e-34	135.0	COG3590@1|root,KOG3624@2759|Eukaryota,38BNF@33154|Opisthokonta,3B9I2@33208|Metazoa,3CW8Q@33213|Bilateria,481YV@7711|Chordata,49434@7742|Vertebrata,3JBKD@40674|Mammalia,4IY13@91561|Cetartiodactyla	33208|Metazoa	E	Endothelin-converting enzyme	ECEL1	GO:0003008,GO:0003016,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0007186,GO:0007218,GO:0007585,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0023052,GO:0031224,GO:0031226,GO:0032501,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	-	ko:K09610	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_910137_1	187272.Mlg_2270	1.45e-46	160.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,1RNUH@1236|Gammaproteobacteria,1X2C7@135613|Chromatiales	135613|Chromatiales	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
k59_910137_2	1207063.P24_02141	6.49e-41	144.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,2JQ3C@204441|Rhodospirillales	204441|Rhodospirillales	P	transport system, permease component	-	-	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
k59_254415_1	1396141.BATP01000066_gene1894	2.94e-77	234.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_Tnp_IS630
k59_254415_2	1396141.BATP01000066_gene1893	2.34e-47	156.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29
k59_784856_1	1165096.ARWF01000001_gene1577	6.77e-21	89.4	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KKB3@206350|Nitrosomonadales	206350|Nitrosomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_784856_2	1266925.JHVX01000005_gene1938	9.67e-18	79.7	COG3312@1|root,COG3312@2|Bacteria,1R3CS@1224|Proteobacteria,2WIGV@28216|Betaproteobacteria,374P5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_784856_3	243365.CV_0664	2.87e-18	84.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,2KQ06@206351|Neisseriales	206351|Neisseriales	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_885168_1	640081.Dsui_1647	6.27e-106	318.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,2KVK4@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_885168_2	1163617.SCD_n00088	2.71e-81	250.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,2VINE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
k59_820513_1	1121937.AUHJ01000004_gene1013	4.04e-137	404.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1T7KM@1236|Gammaproteobacteria,46C37@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_69575_1	159087.Daro_1404	2.62e-19	87.4	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,2VKG8@28216|Betaproteobacteria,2KY24@206389|Rhodocyclales	206389|Rhodocyclales	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_69575_2	338969.Rfer_3094	1.47e-22	98.6	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,4AE6V@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_950855_1	375286.mma_0396	3.2e-133	391.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,476QA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_4118_2	395494.Galf_2722	8.04e-30	111.0	28WAT@1|root,2ZIB9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_885182_1	1266925.JHVX01000005_gene2009	6.36e-77	238.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2VHQV@28216|Betaproteobacteria,3724A@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_885182_2	335283.Neut_1501	2.42e-47	166.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,372IT@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_363024_1	649638.Trad_2416	5.56e-50	174.0	COG0747@1|root,COG0747@2|Bacteria,1WIYQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_363024_2	1502851.FG93_05666	6.49e-75	237.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_591819_1	935948.KE386494_gene944	5.93e-81	253.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_754306_1	1174528.JH992892_gene6327	1.09e-22	101.0	COG3385@1|root,2ZA2Q@2|Bacteria,1G4UP@1117|Cyanobacteria	1117|Cyanobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_167431_1	1123487.KB892838_gene3945	5.45e-44	160.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2VK7T@28216|Betaproteobacteria,2KUKS@206389|Rhodocyclales	28216|Betaproteobacteria	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase
k59_167431_2	323848.Nmul_A2249	2.37e-28	103.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_363025_1	693986.MOC_3574	1.69e-05	50.8	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,1JXBE@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
k59_363025_2	278963.ATWD01000001_gene3726	8.17e-18	82.4	COG1233@1|root,COG1233@2|Bacteria,3Y319@57723|Acidobacteria,2JHK7@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
k59_428337_1	991.IW20_16010	1.26e-83	278.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia,2NTDQ@237|Flavobacterium	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	bepE_4	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_983250_1	477184.KYC_28357	2.02e-44	155.0	COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2VM1T@28216|Betaproteobacteria,3T63J@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Gentisate 1,2-dioxygenase	nagI	-	1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R02656	RC00764	ko00000,ko00001,ko01000	-	-	-	Cupin_2
k59_983250_2	1510531.JQJJ01000014_gene4740	1.3e-69	221.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,3JTG8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	MA20_30275	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_428339_2	312153.Pnuc_0827	1.39e-51	182.0	COG1230@1|root,COG2021@1|root,COG1230@2|Bacteria,COG2021@2|Bacteria,1QUZ5@1224|Proteobacteria,2WGMK@28216|Betaproteobacteria,1KG7M@119060|Burkholderiaceae	28216|Betaproteobacteria	P	TIGRFAM cation diffusion facilitator family transporter	zitB	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Abhydrolase_6,Cation_efflux
k59_36845_1	1163617.SCD_n01113	8.84e-98	309.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_885194_1	883126.HMPREF9710_02338	9.97e-91	286.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,472MA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	ABC transporter	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_689935_1	330214.NIDE2740	4.97e-67	213.0	COG0196@1|root,COG0196@2|Bacteria,3J0KY@40117|Nitrospirae	40117|Nitrospirae	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_689935_2	330214.NIDE2741	3.33e-89	270.0	COG0113@1|root,COG0113@2|Bacteria,3J0DV@40117|Nitrospirae	40117|Nitrospirae	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_297693_1	436308.Nmar_0007	8.3e-71	228.0	COG0652@1|root,arCOG04767@2157|Archaea,41T0W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_657295_1	1229909.NSED_02750	6.16e-124	365.0	COG0422@1|root,arCOG02741@2157|Archaea,41S5Z@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Thiamine biosynthesis protein ThiC	-	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
k59_4140_1	1229909.NSED_02900	4.63e-64	198.0	COG0432@1|root,arCOG04214@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_4140_2	436308.Nmar_1769	6.57e-43	151.0	COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_559342_1	1384056.N787_10225	1.12e-27	107.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,1X35P@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
k59_559342_2	1163617.SCD_n00229	3.03e-23	98.2	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_689940_1	240016.ABIZ01000001_gene1413	3.02e-30	120.0	COG3174@1|root,COG3174@2|Bacteria,46VTJ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
k59_983257_2	383372.Rcas_2542	3.57e-55	179.0	2F76J@1|root,33ZMZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_983257_3	1121920.AUAU01000004_gene735	1.14e-17	81.6	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM glutamate formiminotransferase	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
k59_200020_1	859657.RPSI07_2850	1.31e-145	421.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,1K0G3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
k59_200020_2	580332.Slit_0047	4.5e-45	153.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,44V8V@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Nucleotidyl transferase	rmlA	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_395369_2	1207063.P24_04934	9.58e-59	189.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,2JRQS@204441|Rhodospirillales	204441|Rhodospirillales	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_722478_2	575540.Isop_3224	2.1e-48	161.0	COG4422@1|root,COG4422@2|Bacteria,2IY1I@203682|Planctomycetes	203682|Planctomycetes	S	COG4422 Bacteriophage protein gp37	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
k59_722481_1	330214.NIDE4135	7.49e-60	189.0	COG0779@1|root,COG0779@2|Bacteria,3J0UD@40117|Nitrospirae	40117|Nitrospirae	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_722481_2	1294265.JCM21738_2254	6e-11	62.8	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,4HAWW@91061|Bacilli,1ZBVX@1386|Bacillus	91061|Bacilli	E	Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction	dat	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_36862_1	267608.RSc0679	2.25e-23	98.6	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2VH1E@28216|Betaproteobacteria,1K38Y@119060|Burkholderiaceae	28216|Betaproteobacteria	F	dihydroorotase multifunctional complex type	pyrX	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_36862_2	292415.Tbd_2433	2.63e-174	509.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,1KSEV@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Peptidase family M3	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_265389_1	497964.CfE428DRAFT_0103	1.55e-20	92.0	COG4956@1|root,COG4956@2|Bacteria,46U4H@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_494149_1	1502851.FG93_03601	4.61e-58	193.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,3JUUQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
k59_722485_1	864069.MicloDRAFT_00013950	8.53e-58	192.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,2TQRB@28211|Alphaproteobacteria,1JQZ4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_69631_1	557599.MKAN_06595	5.24e-36	140.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
k59_885234_1	875454.BAEW01000006_gene1060	3.88e-07	52.4	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,22G9F@1570339|Peptoniphilaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_885234_2	1267535.KB906767_gene5021	6.68e-98	298.0	COG0017@1|root,COG0017@2|Bacteria,3Y350@57723|Acidobacteria,2JI7K@204432|Acidobacteriia	204432|Acidobacteriia	J	class II (D K	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_983302_1	1071679.BG57_20640	5.08e-11	68.2	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1K0B4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_200060_1	1499686.BN1079_02527	2.56e-31	120.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	oxidase subunit	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_102184_1	350054.Mflv_3121	1.93e-52	179.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I419@201174|Actinobacteria,234R8@1762|Mycobacteriaceae	201174|Actinobacteria	IK	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Trans_reg_C
k59_559398_1	1504672.669784838	1.7e-12	68.9	COG0664@1|root,COG0664@2|Bacteria,1N437@1224|Proteobacteria,2VU5S@28216|Betaproteobacteria,4AF2J@80864|Comamonadaceae	28216|Betaproteobacteria	T	Cyclic nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_428404_1	765914.ThisiDRAFT_2009	1.16e-109	328.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,1RPTT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_428404_2	1472716.KBK24_0138150	7.29e-05	44.3	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VI2N@28216|Betaproteobacteria,1K414@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_559399_2	1443111.JASG01000004_gene732	3.77e-25	95.1	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3ZXXU@60136|Sulfitobacter	28211|Alphaproteobacteria	K	'Cold-shock' DNA-binding domain	cspA4	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_852813_1	497964.CfE428DRAFT_2226	3.13e-24	102.0	COG2993@1|root,COG2993@2|Bacteria,46T1F@74201|Verrucomicrobia	74201|Verrucomicrobia	C	PFAM cytochrome C oxidase mono-heme subunit FixO	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_560654_1	338963.Pcar_2855	5.39e-42	144.0	COG0824@1|root,COG0824@2|Bacteria,1RCSP@1224|Proteobacteria,42WI3@68525|delta/epsilon subdivisions,2WRN0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
k59_560654_2	1121035.AUCH01000002_gene1479	1.5e-10	60.8	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VJCP@28216|Betaproteobacteria,2KW05@206389|Rhodocyclales	206389|Rhodocyclales	S	SNARE associated Golgi protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_821885_1	1002340.AFCF01000042_gene2057	6.24e-35	126.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria,34FPH@302485|Phaeobacter	28211|Alphaproteobacteria	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
k59_136177_1	1980924.B2ZXU0_9CAUD	7.38e-09	60.5	4QDI9@10239|Viruses,4QU29@28883|Caudovirales	28883|Caudovirales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_952252_1	472759.Nhal_2106	1.47e-78	241.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria,1WXV0@135613|Chromatiales	135613|Chromatiales	S	Cytokinin riboside 5'-monophosphate phosphoribohydrolase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_984544_1	1049564.TevJSym_ab00830	3.4e-51	169.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,1J6WH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_5537_2	614083.AWQR01000058_gene1510	3.05e-14	71.2	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2VICF@28216|Betaproteobacteria,4AAP2@80864|Comamonadaceae	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	ugpE	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
k59_201300_1	338969.Rfer_1860	5.72e-38	138.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2VJMX@28216|Betaproteobacteria,4AB3Y@80864|Comamonadaceae	28216|Betaproteobacteria	O	FeS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_201300_2	323848.Nmul_A0697	1.45e-90	272.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2VNGT@28216|Betaproteobacteria,371MH@32003|Nitrosomonadales	28216|Betaproteobacteria	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_266648_1	1191523.MROS_1149	1.33e-54	188.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
k59_761976_1	670307.HYPDE_24063	9e-86	266.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria,3N6AT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_601319_1	991905.SL003B_2672	1.2e-79	251.0	COG0742@1|root,COG0742@2|Bacteria,1MW6A@1224|Proteobacteria,2TQNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ribosomal rna small subunit methyltransferase	MA20_07810	-	-	-	-	-	-	-	-	-	-	-	-
k59_503745_1	926550.CLDAP_30940	1.35e-70	227.0	COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28,4.1.2.27	ko:K01593,ko:K01634	ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034	M00037,M00042,M00100	R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_633695_1	399739.Pmen_0145	1.56e-36	134.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1YEXF@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Cytochrome c oxidase subunit III	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_339986_1	545276.KB898725_gene774	3.12e-35	130.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_339986_2	1219375.CM002139_gene873	8.61e-27	99.8	COG5007@1|root,COG5007@2|Bacteria,1R3MK@1224|Proteobacteria,1SE4M@1236|Gammaproteobacteria,1X7EE@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the BolA IbaG family	SN15_13775	-	-	-	-	-	-	-	-	-	-	-	BolA
k59_830319_1	1500897.JQNA01000002_gene148	2.21e-86	273.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2VI17@28216|Betaproteobacteria,1K3PV@119060|Burkholderiaceae	28216|Betaproteobacteria	P	permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_568958_1	655815.ZPR_2017	1.59e-51	181.0	COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1I0RF@117743|Flavobacteriia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_13993_1	105559.Nwat_0513	9.88e-50	171.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1WW9C@135613|Chromatiales	135613|Chromatiales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_403006_1	1229780.BN381_400017	3.42e-77	242.0	COG1960@1|root,COG1960@2|Bacteria,2GIXS@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_79336_3	292415.Tbd_1463	4.72e-35	121.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,1KTBN@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Translation initiation factor 1A / IF-1	-	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_79336_4	45130.XP_007705870.1	1.59e-07	57.4	2ARPT@1|root,2RZMU@2759|Eukaryota,3AFXZ@33154|Opisthokonta,3PARY@4751|Fungi,3R120@4890|Ascomycota	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_437445_2	753084.F4YCI8_9CAUD	2.79e-05	47.8	4QUTY@35237|dsDNA viruses  no RNA stage,4QM17@10699|Siphoviridae	10699|Siphoviridae	S	Protein of unknwon function (DUF3310)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_468220_1	1288494.EBAPG3_7930	1.39e-73	224.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2VR9P@28216|Betaproteobacteria,3732R@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_468220_2	1163617.SCD_n00837	5.23e-70	223.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_239740_2	1123261.AXDW01000018_gene768	5.86e-35	127.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1S8HN@1236|Gammaproteobacteria,1X62E@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_894144_1	251229.Chro_2222	1.61e-36	134.0	COG2062@1|root,COG2062@2|Bacteria,1G76N@1117|Cyanobacteria,3VMHX@52604|Pleurocapsales	1117|Cyanobacteria	T	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_633738_1	323261.Noc_0785	6.65e-80	251.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Sigma54_activat
k59_732253_1	76114.ebA5421	1.02e-69	218.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,2KVC2@206389|Rhodocyclales	206389|Rhodocyclales	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_861982_1	436308.Nmar_0404	7.43e-66	207.0	COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota	651137|Thaumarchaeota	U	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
k59_403038_1	330214.NIDE2487	4.74e-118	355.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N,MutL
k59_503793_1	96561.Dole_1001	2.14e-83	259.0	COG1150@1|root,COG1150@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	qmoC	-	-	ko:K16887	-	-	-	-	ko00000	-	-	-	Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam
k59_732260_1	506534.Rhein_1442	4.13e-05	44.7	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_732260_2	402881.Plav_0176	2.39e-33	127.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,1JNR3@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_306539_1	330214.NIDE0344	1.87e-116	342.0	COG0714@1|root,COG0714@2|Bacteria,3J0WQ@40117|Nitrospirae	40117|Nitrospirae	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_992506_1	395495.Lcho_3063	7.02e-109	332.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,1KJ35@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_79378_1	338969.Rfer_3440	1.22e-49	168.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,4AADM@80864|Comamonadaceae	28216|Betaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_79378_2	1392838.AWNM01000009_gene2761	2.1e-44	149.0	COG1522@1|root,COG1522@2|Bacteria,1RD38@1224|Proteobacteria,2VRBA@28216|Betaproteobacteria,3T3UK@506|Alcaligenaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
k59_601367_2	1463858.JOHR01000001_gene6365	1.06e-69	221.0	COG3424@1|root,COG3424@2|Bacteria,2GV0U@201174|Actinobacteria	201174|Actinobacteria	Q	synthase	pks11	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
k59_79384_1	909613.UO65_3480	3.97e-42	147.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4E0H5@85010|Pseudonocardiales	201174|Actinobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.24,4.1.3.25	ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200	M00346,M00373,M00376	R00237,R00473,R00934	RC00307,RC00308,RC00311,RC00407,RC00502,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
k59_79384_3	1283299.AUKG01000002_gene4334	4.83e-11	62.8	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4CSIF@84995|Rubrobacteria	84995|Rubrobacteria	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,Succ_CoA_lig
k59_861998_1	765913.ThidrDRAFT_2527	1.86e-20	87.8	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1WY36@135613|Chromatiales	135613|Chromatiales	E	PFAM lipolytic protein G-D-S-L family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
k59_861998_2	305700.B447_12669	1.51e-26	104.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,2KUMK@206389|Rhodocyclales	206389|Rhodocyclales	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_732269_1	498211.CJA_2943	6.82e-62	207.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1FH61@10|Cellvibrio	1236|Gammaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_4,sCache_2
k59_437500_2	997884.HMPREF1068_03756	2.64e-11	66.6	COG1214@1|root,COG1214@2|Bacteria,4NDUR@976|Bacteroidetes,2FPYK@200643|Bacteroidia,4AMVK@815|Bacteroidaceae	976|Bacteroidetes	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_306555_1	314254.OA2633_12240	3.58e-32	120.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,43XPT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Polyhydroxyalkanoate synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
k59_928216_1	1500257.JQNM01000026_gene5	1.18e-43	148.0	COG1442@1|root,COG1442@2|Bacteria,1QH4S@1224|Proteobacteria,2U9KQ@28211|Alphaproteobacteria,4B9U9@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_209317_1	1236959.BAMT01000002_gene2014	1.48e-52	184.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KM44@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_667104_1	509635.N824_06550	6.25e-28	118.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NEIE@976|Bacteroidetes,1IQG7@117747|Sphingobacteriia	976|Bacteroidetes	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug,TonB_dep_Rec
k59_503818_1	880072.Desac_2017	3.91e-85	263.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2MQZG@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	livK-1	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1823	Peripla_BP_6
k59_830404_1	269797.Mbar_A3250	5.65e-08	59.7	COG0642@1|root,arCOG03567@1|root,arCOG02358@2157|Archaea,arCOG03567@2157|Archaea,2Y7NU@28890|Euryarchaeota,2NAAT@224756|Methanomicrobia	224756|Methanomicrobia	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS,PAS_3
k59_732290_1	1454004.AW11_01978	6.2e-81	255.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJ1B@28216|Betaproteobacteria	28216|Betaproteobacteria	M	RND efflux system, outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_79409_1	765910.MARPU_04800	2.32e-69	228.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1WXBI@135613|Chromatiales	135613|Chromatiales	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_340068_1	1278073.MYSTI_05650	1.21e-69	227.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	crdA	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_239798_1	335543.Sfum_0746	1.03e-42	157.0	COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MR2F@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	acetyl-CoA	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
k59_468280_1	62928.azo2292	4.56e-64	207.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2VIAK@28216|Betaproteobacteria,2KUGK@206389|Rhodocyclales	206389|Rhodocyclales	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18
k59_47246_1	338969.Rfer_3779	2.46e-36	141.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,4AAXQ@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_403878_2	265072.Mfla_0235	6.73e-61	209.0	COG0642@1|root,COG0642@2|Bacteria,1R49A@1224|Proteobacteria,2VKU5@28216|Betaproteobacteria,2KMC6@206350|Nitrosomonadales	206350|Nitrosomonadales	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_634737_1	1121937.AUHJ01000011_gene2895	9.25e-22	97.1	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,1RSGE@1236|Gammaproteobacteria,4687X@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_862944_1	665956.HMPREF1032_03571	2.07e-15	79.3	COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia,3WJZD@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_895105_1	1380394.JADL01000007_gene4469	6.29e-87	263.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,2TVMU@28211|Alphaproteobacteria,2JU2U@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_602352_1	1049564.TevJSym_ag00880	1.04e-122	368.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1JAJ9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Fumarate reductase flavoprotein C-term	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_373173_1	794903.OPIT5_07150	8.45e-59	192.0	COG4120@1|root,COG4120@2|Bacteria,46YK2@74201|Verrucomicrobia,3K9RK@414999|Opitutae	414999|Opitutae	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
k59_145398_1	1001240.GY21_05165	5.92e-40	146.0	COG1593@1|root,COG1593@2|Bacteria,2GXEY@201174|Actinobacteria,4FP57@85023|Microbacteriaceae	201174|Actinobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_15023_1	398525.KB900701_gene680	2.13e-119	357.0	COG3119@1|root,COG3119@2|Bacteria,1MV4J@1224|Proteobacteria,2TT2I@28211|Alphaproteobacteria,3JVIP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_961793_1	740709.A10D4_05207	1.51e-37	140.0	28JNG@1|root,2Z9ES@2|Bacteria,1N32V@1224|Proteobacteria,1S9AH@1236|Gammaproteobacteria,2QGP2@267893|Idiomarinaceae	1236|Gammaproteobacteria	-	-	pgsW	-	-	-	-	-	-	-	-	-	-	-	-
k59_993491_1	1304883.KI912532_gene1675	5.13e-71	221.0	COG0121@1|root,COG0121@2|Bacteria,1MU1J@1224|Proteobacteria,2VJP1@28216|Betaproteobacteria,2KVVH@206389|Rhodocyclales	206389|Rhodocyclales	S	glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4
k59_993491_2	292415.Tbd_0218	8.09e-12	62.0	COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,2VU7S@28216|Betaproteobacteria,1KRRV@119069|Hydrogenophilales	119069|Hydrogenophilales	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT
k59_47275_1	330214.NIDE2474	2.21e-56	184.0	2DGGU@1|root,2ZVXA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_634761_1	314285.KT71_14454	6.32e-75	242.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1J818@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_15024_2	330214.NIDE1278	3.91e-112	328.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	yxlG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
k59_307454_1	29581.BW37_05133	8.93e-202	568.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2VHXK@28216|Betaproteobacteria,476HN@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Domain of unknown function (DUF4147)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_895127_1	420324.KI911999_gene8065	7.22e-71	225.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,1JQQ0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	PFAM Glucose Sorbosone dehydrogenase	yliI	-	1.1.5.2	ko:K00117,ko:K21430	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	GSDH
k59_177960_2	1121422.AUMW01000003_gene921	1.19e-11	65.9	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,24M2Q@186801|Clostridia,261QR@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
k59_570066_1	1348657.M622_04885	9.91e-69	224.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,2VUMQ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_314701_1	1000565.METUNv1_00401	3.31e-51	182.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KUJW@206389|Rhodocyclales	206389|Rhodocyclales	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_741641_1	349521.HCH_04864	1.03e-74	251.0	COG2866@1|root,COG4935@1|root,COG2866@2|Bacteria,COG4935@2|Bacteria,1PFUZ@1224|Proteobacteria,1RYRG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	PKD,P_proprotein,Peptidase_M14
k59_120818_1	1121405.dsmv_2223	8.12e-128	367.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2WKJ3@28221|Deltaproteobacteria,2MIDE@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter related	lolD-2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_120818_2	1121439.dsat_0860	9.54e-12	64.7	COG0577@1|root,COG0577@2|Bacteria,1RC4T@1224|Proteobacteria,42QZ6@68525|delta/epsilon subdivisions,2WMU4@28221|Deltaproteobacteria,2MB5S@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_314708_1	1232410.KI421421_gene3446	3.04e-46	162.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,42TEX@68525|delta/epsilon subdivisions,2WPG8@28221|Deltaproteobacteria,43T5H@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_348967_1	1247726.MIM_c01930	1.59e-91	277.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,3T2W1@506|Alcaligenaceae	28216|Betaproteobacteria	G	C4-dicarboxylate ABC transporter	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
k59_54910_1	292415.Tbd_0703	9.47e-86	258.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,2VQ3T@28216|Betaproteobacteria	28216|Betaproteobacteria	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_54910_2	1288494.EBAPG3_16980	1.82e-29	105.0	COG1942@1|root,COG1942@2|Bacteria,1NC22@1224|Proteobacteria,2VWHU@28216|Betaproteobacteria,373MV@32003|Nitrosomonadales	28216|Betaproteobacteria	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_54910_3	582744.Msip34_1005	6.63e-124	372.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,2KMD9@206350|Nitrosomonadales	206350|Nitrosomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_314711_1	96561.Dole_2556	5.63e-50	168.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,42QER@68525|delta/epsilon subdivisions,2WM9B@28221|Deltaproteobacteria,2MK1C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_23131_1	944479.JQLX01000013_gene1394	1.73e-16	79.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,2M6V3@213113|Desulfurellales	28221|Deltaproteobacteria	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_120828_1	330214.NIDE1807	8.86e-07	50.1	COG1132@1|root,COG1132@2|Bacteria,3J0X8@40117|Nitrospirae	40117|Nitrospirae	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_120828_2	330214.NIDE1806	3.98e-62	194.0	COG0242@1|root,COG0242@2|Bacteria,3J146@40117|Nitrospirae	40117|Nitrospirae	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_314713_3	1128421.JAGA01000001_gene2319	6.41e-12	67.4	COG3023@1|root,COG3409@1|root,COG3023@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	pdcA	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,PG_binding_1
k59_277762_1	365044.Pnap_2180	5.97e-125	385.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_769926_1	1499680.CCFE01000021_gene2139	4.42e-18	82.8	COG4577@1|root,COG4577@2|Bacteria,1VB4A@1239|Firmicutes,4HKGU@91061|Bacilli,1ZICX@1386|Bacillus	91061|Bacilli	CQ	BMC	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
k59_23146_1	164757.Mjls_1673	3.57e-56	187.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,237DD@1762|Mycobacteriaceae	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_247515_1	1266925.JHVX01000003_gene528	4.52e-42	143.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,3738S@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Nudix hydrolase	ntpA	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
k59_247515_2	159087.Daro_3766	1.06e-12	67.4	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,2KUN9@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_120838_1	1167006.UWK_02231	3.07e-44	160.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_642707_1	357808.RoseRS_0353	4.59e-120	362.0	COG4467@1|root,COG4467@2|Bacteria,2G8CX@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
k59_791700_1	232348.ADXL01000054_gene1763	2.16e-25	110.0	COG0668@1|root,COG0668@2|Bacteria,1GHCQ@1117|Cyanobacteria,1GZV2@1129|Synechococcus	1117|Cyanobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_277771_1	1459636.NTE_00099	1.58e-24	92.8	arCOG02240@1|root,arCOG02240@2157|Archaea,41SSM@651137|Thaumarchaeota	651137|Thaumarchaeota	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_839827_1	857087.Metme_0098	2.04e-39	134.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1XF63@135618|Methylococcales	135618|Methylococcales	P	ApaG domain	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_839827_2	1298593.TOL_0596	1.65e-30	115.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1XH8Y@135619|Oceanospirillales	135619|Oceanospirillales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_380819_1	713586.KB900536_gene353	2.42e-74	238.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1WZEX@135613|Chromatiales	135613|Chromatiales	H	DinB superfamily	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
k59_512986_1	402881.Plav_0576	2.11e-10	62.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	MA20_22865	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_512986_2	404589.Anae109_4467	1.7e-41	144.0	COG1100@1|root,COG1100@2|Bacteria,1RCJJ@1224|Proteobacteria,42R57@68525|delta/epsilon subdivisions,2WN5Y@28221|Deltaproteobacteria,2YUYK@29|Myxococcales	28221|Deltaproteobacteria	S	Small GTP-binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
k59_578291_2	1288494.EBAPG3_2710	1.14e-34	120.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2VTYP@28216|Betaproteobacteria,373G4@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_446266_1	323848.Nmul_A2335	2.26e-90	271.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,3720T@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_88682_1	436308.Nmar_1034	4.29e-135	392.0	COG5256@1|root,arCOG01561@2157|Archaea,41SD2@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_23163_1	436308.Nmar_1420	7.4e-66	211.0	COG0104@1|root,arCOG04387@2157|Archaea,41SCA@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_839833_1	667632.KB890173_gene3889	1.56e-63	214.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,1JZWN@119060|Burkholderiaceae	28216|Betaproteobacteria	M	D-alanyl-d-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
k59_514003_2	522306.CAP2UW1_3465	3.37e-43	150.0	COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VJQ5@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_643713_1	1459636.NTE_02371	1.71e-78	253.0	COG0365@1|root,arCOG01529@2157|Archaea,41S8Z@651137|Thaumarchaeota	651137|Thaumarchaeota	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_411705_1	243233.MCA2437	7.2e-05	43.5	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1XF1V@135618|Methylococcales	135618|Methylococcales	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_350019_1	323848.Nmul_A0001	3.49e-115	343.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,372M3@32003|Nitrosomonadales	28216|Betaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_514008_2	1054213.HMPREF9946_00792	2.12e-38	137.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_938552_1	1265502.KB905945_gene662	1.07e-77	244.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2VI5S@28216|Betaproteobacteria,4AB0T@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM type III effector Hrp-dependent outers	hop	-	2.7.1.217	ko:K21948	-	-	R11706,R11707	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
k59_840873_1	644282.Deba_1972	6.8e-07	51.2	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,42M2V@68525|delta/epsilon subdivisions,2WKEB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	RNA methylase	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
k59_840873_2	335543.Sfum_2001	1.6e-83	258.0	COG0697@1|root,COG0697@2|Bacteria,1MUQ7@1224|Proteobacteria,42R74@68525|delta/epsilon subdivisions,2WMRT@28221|Deltaproteobacteria,2MRGD@213462|Syntrophobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_447217_1	189753.AXAS01000073_gene7662	4.29e-67	218.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system periplasmic component	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_792123_1	631454.N177_3819	8.84e-81	255.0	COG3333@1|root,COG3333@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_971221_1	1218076.BAYB01000006_gene1085	1.82e-45	160.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VQ3B@28216|Betaproteobacteria,1JZYZ@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_971221_2	85643.Tmz1t_3017	4.36e-124	359.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,2KU8F@206389|Rhodocyclales	206389|Rhodocyclales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_742732_1	1123073.KB899241_gene3135	7.93e-13	67.8	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1S1PR@1236|Gammaproteobacteria,1X4CU@135614|Xanthomonadales	135614|Xanthomonadales	Q	abc transporter atp-binding protein	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_742732_2	589865.DaAHT2_1296	4.62e-08	54.7	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,2MKRJ@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM toluene tolerance family protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_643724_1	368408.Tpen_1350	7.69e-52	181.0	COG1473@1|root,arCOG01108@2157|Archaea,2XRII@28889|Crenarchaeota	28889|Crenarchaeota	E	carboxypeptidase activity	-	-	-	ko:K12941,ko:K13048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_476719_1	1349767.GJA_3586	1.82e-60	210.0	COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	U	TIGRFAM filamentous haemagglutinin family outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ESPR,Glug,Haemagg_act
k59_89719_1	330214.NIDE1738	1.27e-46	162.0	COG1893@1|root,COG2041@1|root,COG1893@2|Bacteria,COG2041@2|Bacteria,3J0S5@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_89719_2	330214.NIDE1737	1.22e-59	189.0	COG0846@1|root,COG0846@2|Bacteria,3J15J@40117|Nitrospirae	40117|Nitrospirae	K	Belongs to the sirtuin family. Class	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_55899_1	331869.BAL199_26217	4.47e-09	57.8	COG4177@1|root,COG4177@2|Bacteria,1QF6I@1224|Proteobacteria,2TRTF@28211|Alphaproteobacteria,4BS7G@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_55899_2	331869.BAL199_26222	1.19e-49	166.0	COG0559@1|root,COG0559@2|Bacteria,1MYEW@1224|Proteobacteria,2TQQZ@28211|Alphaproteobacteria,4BS15@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_792126_1	1499967.BAYZ01000008_gene5418	8.43e-31	115.0	COG0834@1|root,COG0834@2|Bacteria	2|Bacteria	ET	amino acid transport	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_792126_2	536019.Mesop_3122	1.21e-41	148.0	COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria	1224|Proteobacteria	E	Saccharopine dehydrogenase	lys2	-	1.4.1.18,1.5.1.10	ko:K00293,ko:K19064	ko00300,ko00310,ko00960,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map00960,map01100,map01110,map01130,map01230	M00030,M00032	R00446,R02315,R02317	RC00062,RC00215,RC00225,RC00694	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_315658_1	1210884.HG799464_gene10928	2.39e-23	97.8	COG5433@1|root,COG5433@2|Bacteria,2J33X@203682|Planctomycetes	203682|Planctomycetes	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_55908_1	1380350.JIAP01000014_gene3555	9.01e-45	149.0	COG1873@1|root,COG1873@2|Bacteria,1MYBI@1224|Proteobacteria,2U97H@28211|Alphaproteobacteria,43JWK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
k59_742754_1	384765.SIAM614_01624	1.15e-73	228.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_24194_1	198467.NP92_01245	7.12e-21	98.6	COG0745@1|root,COG2198@1|root,COG2199@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG3706@2|Bacteria,1TSW8@1239|Firmicutes,4HBT1@91061|Bacilli,21WG1@150247|Anoxybacillus	91061|Bacilli	T	Hpt domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Hpt,Response_reg
k59_872083_1	261292.Nit79A3_2078	3.14e-19	82.4	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria,373CA@32003|Nitrosomonadales	28216|Betaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_872083_2	498211.CJA_0438	9.7e-40	142.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1FFXS@10|Cellvibrio	1236|Gammaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_411745_1	330214.NIDE1586	3.35e-67	218.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,GAF_3,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,dCache_1
k59_903671_1	980584.AFPB01000174_gene1596	6.6e-31	113.0	COG0399@1|root,COG0399@2|Bacteria,4P9JE@976|Bacteroidetes,1IGJK@117743|Flavobacteriia,4078G@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_903671_2	1121904.ARBP01000002_gene6976	3.51e-24	97.1	COG0745@1|root,COG0745@2|Bacteria,4NGXP@976|Bacteroidetes	976|Bacteroidetes	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_643756_1	749222.Nitsa_1296	2.14e-27	108.0	COG3677@1|root,COG3677@2|Bacteria,1RBA7@1224|Proteobacteria,4304X@68525|delta/epsilon subdivisions,2YRUF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_315675_1	398578.Daci_1953	1.93e-39	148.0	28S81@1|root,2ZEJD@2|Bacteria,1RCNN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1002355_1	990285.RGCCGE502_25703	4.44e-22	95.1	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,4B9MM@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_1002355_2	408672.NBCG_01521	3.75e-06	51.6	293R6@1|root,2ZR6U@2|Bacteria,2HRYX@201174|Actinobacteria,4DR6V@85009|Propionibacteriales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
k59_447255_1	7668.SPU_016320-tr	3.89e-22	100.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_872095_1	760568.Desku_0164	1.14e-20	90.5	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26073@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_872095_2	1449126.JQKL01000003_gene1813	9.55e-35	133.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_611422_1	1449976.KALB_5825	5.56e-21	95.9	COG2124@1|root,COG2124@2|Bacteria,2I9JQ@201174|Actinobacteria,4E16R@85010|Pseudonocardiales	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_154569_2	85643.Tmz1t_2464	1.12e-10	65.5	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,2KUM2@206389|Rhodocyclales	206389|Rhodocyclales	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_89758_1	757424.Hsero_0426	5.67e-104	327.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,4724U@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_579418_1	177437.HRM2_00660	1.69e-67	227.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,2MN0V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_971268_1	756272.Plabr_2324	4.86e-51	186.0	COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes	203682|Planctomycetes	G	COG0058 Glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_946071_1	1205680.CAKO01000014_gene123	1.1e-10	62.4	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TSGF@28211|Alphaproteobacteria,2JPV5@204441|Rhodospirillales	204441|Rhodospirillales	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
k59_946071_2	69395.JQLZ01000010_gene4179	2.71e-18	85.1	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,2KFTA@204458|Caulobacterales	204458|Caulobacterales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692,ko:K01715	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_650846_1	1380394.JADL01000004_gene6056	5.98e-74	238.0	COG4664@1|root,COG4664@2|Bacteria,1QU8F@1224|Proteobacteria,2TYAS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_777493_1	1453505.JASY01000014_gene4374	2.77e-68	220.0	COG0657@1|root,COG0657@2|Bacteria,4PKDQ@976|Bacteroidetes,1HXR3@117743|Flavobacteriia,2NU4D@237|Flavobacterium	976|Bacteroidetes	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_357431_1	261292.Nit79A3_1727	2.35e-114	341.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,372TF@32003|Nitrosomonadales	28216|Betaproteobacteria	KT	PFAM Metal-dependent phosphohydrolase, HD	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,GAF_2,HD
k59_226151_1	1160137.KB907307_gene4242	9.77e-06	52.8	COG2303@1|root,COG2303@2|Bacteria,2GJKS@201174|Actinobacteria,4FVKM@85025|Nocardiaceae	201174|Actinobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3
k59_418248_1	326427.Cagg_3755	3.72e-45	166.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2GBRR@200795|Chloroflexi,376B2@32061|Chloroflexia	32061|Chloroflexia	D	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA,VWA_2
k59_521701_1	76114.ebA4755	6.65e-10	58.9	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,2KVMZ@206389|Rhodocyclales	206389|Rhodocyclales	O	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_521701_2	234267.Acid_5133	3.32e-85	265.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	serA5	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_521701_3	1163617.SCD_n01692	1.27e-185	526.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,2VM95@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_1009367_1	1380394.JADL01000003_gene5080	1.79e-97	296.0	COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,2JRVV@204441|Rhodospirillales	204441|Rhodospirillales	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_1009367_2	1392838.AWNM01000097_gene171	1.38e-83	259.0	COG1960@1|root,COG1960@2|Bacteria,1Q9M3@1224|Proteobacteria,2WATR@28216|Betaproteobacteria,3T6Q4@506|Alcaligenaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_322327_1	436308.Nmar_1086	5.98e-118	347.0	COG0505@1|root,arCOG00064@2157|Archaea,41SF0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_1009371_1	1280953.HOC_15282	1.54e-25	105.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,43XQP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	taurine catabolism dioxygenase	MA20_23235	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_717811_1	404589.Anae109_1606	1.06e-88	279.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,437ZU@68525|delta/epsilon subdivisions,2X39R@28221|Deltaproteobacteria,2YV0T@29|Myxococcales	28221|Deltaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_161675_1	365046.Rta_05500	1.89e-85	263.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VJCK@28216|Betaproteobacteria,4A9UI@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
k59_618608_1	1292034.OR37_00810	1.78e-14	81.6	COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,2TSK9@28211|Alphaproteobacteria,2KG3M@204458|Caulobacterales	204458|Caulobacterales	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_587072_1	1163617.SCD_n02434	1.88e-52	187.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_226168_1	378806.STAUR_0942	2.82e-63	204.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,4383U@68525|delta/epsilon subdivisions,2X3DT@28221|Deltaproteobacteria,2YVM7@29|Myxococcales	28221|Deltaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_521724_1	1131814.JAFO01000001_gene4785	8.71e-43	145.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2U9M7@28211|Alphaproteobacteria,3EZSG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	RF-1 domain	MA20_05665	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_254942_1	639282.DEFDS_1835	4.72e-11	63.5	COG1024@1|root,COG1024@2|Bacteria,2GFDF@200930|Deferribacteres	200930|Deferribacteres	I	enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_717825_1	1510531.JQJJ01000010_gene2442	3.56e-61	197.0	COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2UB0B@28211|Alphaproteobacteria,3K48K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_63032_1	76114.ebA7220	3.84e-160	467.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,2KV9F@206389|Rhodocyclales	206389|Rhodocyclales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_879220_1	1101189.AQUO01000002_gene175	7.31e-113	334.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2TR02@28211|Alphaproteobacteria,2PWCR@265|Paracoccus	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_129243_1	243233.MCA2832	6.34e-28	116.0	COG2982@1|root,COG3164@1|root,COG2982@2|Bacteria,COG3164@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XE60@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_322355_1	1437824.BN940_03676	1.16e-32	120.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2VM1S@28216|Betaproteobacteria,3T2VV@506|Alcaligenaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_322355_2	1286631.X805_36920	3.79e-33	127.0	COG1021@1|root,COG1021@2|Bacteria,1NSN8@1224|Proteobacteria,2WGU9@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_455359_2	196367.JNFG01000214_gene1304	2.23e-152	444.0	COG3464@1|root,COG3464@2|Bacteria,1R8HI@1224|Proteobacteria,2VT67@28216|Betaproteobacteria,1KHTC@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,TrfA
k59_1027931_1	640081.Dsui_3086	1.93e-92	285.0	COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,2VJXB@28216|Betaproteobacteria,2KVPI@206389|Rhodocyclales	206389|Rhodocyclales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_64048_1	639283.Snov_4357	9.55e-22	99.8	COG3941@1|root,COG3941@2|Bacteria,1QVE0@1224|Proteobacteria,2TWCY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_358679_1	596152.DesU5LDRAFT_1477	6.03e-14	69.7	COG1555@1|root,COG1555@2|Bacteria,1N7MI@1224|Proteobacteria,436VE@68525|delta/epsilon subdivisions,2X1JE@28221|Deltaproteobacteria,2MF6R@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
k59_194864_1	105559.Nwat_0237	2.73e-65	222.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_282860_1	1229909.NSED_08755	1.37e-20	88.6	arCOG05137@1|root,arCOG05137@2157|Archaea	2157|Archaea	S	TPR repeat	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	TPR_1,TPR_8
k59_282860_2	1229909.NSED_08750	5.42e-44	147.0	COG0307@1|root,arCOG04713@2157|Archaea,41SKQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	riboflavin synthase, alpha	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_1010363_1	1122915.AUGY01000031_gene7550	3.25e-90	273.0	COG0667@1|root,COG0667@2|Bacteria,1UHXA@1239|Firmicutes,4HDI7@91061|Bacilli,26U1C@186822|Paenibacillaceae	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_389999_1	156889.Mmc1_1986	4.04e-72	231.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_358690_1	1430440.MGMSRv2_2000	1.05e-33	122.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2TURW@28211|Alphaproteobacteria,2JPFC@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome c-type protein	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
k59_162734_1	290397.Adeh_2791	1.69e-91	294.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_911699_1	237368.SCABRO_03854	6.28e-22	102.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
k59_130286_1	384676.PSEEN2124	2.81e-64	222.0	COG2132@1|root,COG2304@1|root,COG2132@2|Bacteria,COG2304@2|Bacteria,1QZ1I@1224|Proteobacteria,1S18S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22350	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2
k59_1027944_1	247490.KSU1_B0100	1.77e-137	401.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_778407_1	95619.PM1_0228365	2.27e-21	97.8	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	HA62_09750	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_323368_1	1187851.A33M_4207	1.47e-100	299.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	gltA	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_911707_1	1408428.JNJP01000004_gene2873	3.88e-09	59.3	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42RHZ@68525|delta/epsilon subdivisions,2WNHI@28221|Deltaproteobacteria,2MASQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_282873_1	903818.KI912268_gene3365	1.91e-88	264.0	COG1100@1|root,COG1100@2|Bacteria,3Y7CQ@57723|Acidobacteria	57723|Acidobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
k59_778409_1	1116369.KB890024_gene1272	1.05e-16	79.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,43IT5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	alkK	-	6.2.1.44,6.2.1.48	ko:K00666,ko:K02182,ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_778409_2	1282876.BAOK01000001_gene2733	5.25e-49	171.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,4BRTT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	alkK	-	6.2.1.44,6.2.1.48	ko:K00666,ko:K02182,ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_227202_2	449447.MAE_54690	1.13e-10	62.0	COG4678@1|root,COG4678@2|Bacteria,1G3VG@1117|Cyanobacteria	1117|Cyanobacteria	G	Muramidase (Phage lambda lysozyme)	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23,Phage_lysozyme
k59_227208_1	1430440.MGMSRv2_0795	1.21e-27	114.0	COG2271@1|root,COG2271@2|Bacteria,1R8Q1@1224|Proteobacteria,2U16E@28211|Alphaproteobacteria,2JRZF@204441|Rhodospirillales	204441|Rhodospirillales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_64107_1	159087.Daro_1123	3.93e-11	62.8	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,2KVRY@206389|Rhodocyclales	206389|Rhodocyclales	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_64107_2	62928.azo0449	6.51e-32	124.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KVGM@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_619677_1	395494.Galf_1744	3.37e-12	67.4	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2VM3G@28216|Betaproteobacteria,44W8Z@713636|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
k59_619677_2	1123392.AQWL01000003_gene452	6.22e-84	268.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,1KSD8@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Polyphosphate kinase middle domain	-	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_778430_1	314264.ROS217_02565	8.59e-82	261.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,46QK0@74030|Roseovarius	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
k59_880246_1	747365.Thena_0113	3.47e-09	63.2	COG2801@1|root,COG2801@2|Bacteria,1TT8V@1239|Firmicutes,24BFH@186801|Clostridia,42ETS@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve
k59_358740_1	1123399.AQVE01000023_gene419	1.11e-22	98.6	COG3166@1|root,COG3166@2|Bacteria,1RJTG@1224|Proteobacteria,1S6RT@1236|Gammaproteobacteria,4633V@72273|Thiotrichales	72273|Thiotrichales	NU	Fimbrial assembly protein (PilN)	-	-	-	-	-	-	-	-	-	-	-	-	PilN
k59_358740_2	243233.MCA1122	2.19e-09	60.8	2DKUH@1|root,30CV1@2|Bacteria,1NCRM@1224|Proteobacteria,1SBMH@1236|Gammaproteobacteria,1XGYH@135618|Methylococcales	135618|Methylococcales	S	Type II secretion system (T2SS), protein M subtype b	-	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM_b
k59_194925_1	1121434.AULY01000006_gene929	1.77e-66	224.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_323403_1	945713.IALB_1358	2.27e-16	75.9	COG0811@1|root,COG0811@2|Bacteria	2|Bacteria	U	bacteriocin transport	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1027965_1	76114.p2A146	2.66e-123	363.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VK6J@28216|Betaproteobacteria,2KX2N@206389|Rhodocyclales	206389|Rhodocyclales	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_911745_1	158500.BV97_05781	1.77e-51	177.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_194932_1	59538.XP_005977321.1	5.63e-27	107.0	COG1143@1|root,KOG3256@2759|Eukaryota,38HK4@33154|Opisthokonta,3BBQ9@33208|Metazoa,3CU2A@33213|Bilateria,481V3@7711|Chordata,48ZAF@7742|Vertebrata,3JEVS@40674|Mammalia,4J6KM@91561|Cetartiodactyla	59538.XP_005977321.1|-	C	NADH dehydrogenase ubiquinone iron-sulfur protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_194932_2	1255043.TVNIR_3118	3.1e-73	223.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1WWN9@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_483925_1	1232437.KL661964_gene3331	2.22e-91	280.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42N47@68525|delta/epsilon subdivisions,2WIKZ@28221|Deltaproteobacteria,2MIEN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	qrcD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_358769_2	864702.OsccyDRAFT_4322	1.12e-74	235.0	COG3385@1|root,COG3385@2|Bacteria,1G7HA@1117|Cyanobacteria,1HHM3@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_194949_1	317655.Sala_0910	4.81e-99	305.0	COG0318@1|root,COG0318@2|Bacteria,1MXAV@1224|Proteobacteria,2U3TX@28211|Alphaproteobacteria,2K1RX@204457|Sphingomonadales	204457|Sphingomonadales	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_282909_1	406124.ACPC01000012_gene1098	4.44e-21	97.8	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,1ZBBU@1386|Bacillus	91061|Bacilli	KLT	serine threonine protein kinase	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_130365_1	243231.GSU3627	6.51e-82	251.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,43T81@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_227260_1	485913.Krac_11260	5.71e-57	196.0	COG0021@1|root,COG0021@2|Bacteria,2G63Z@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_795362_1	436308.Nmar_0296	0.000853	42.0	COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_795362_2	436308.Nmar_0299	2.76e-64	210.0	COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim,Transketolase_N
k59_358785_2	330214.NIDE0144	4.65e-104	323.0	COG0380@1|root,COG0380@2|Bacteria,3J109@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
k59_64165_1	795666.MW7_2892	3.63e-40	146.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria,1K4EB@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_64165_2	1458275.AZ34_09560	2.28e-12	67.4	COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2VMJE@28216|Betaproteobacteria,4AC93@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_778483_1	264462.Bd2858	2.28e-34	132.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,42QPP@68525|delta/epsilon subdivisions,2MTXU@213481|Bdellovibrionales,2X5P5@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_911800_1	557598.LHK_02675	3.61e-86	260.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2VHYY@28216|Betaproteobacteria,2KPW5@206351|Neisseriales	206351|Neisseriales	P	ABC transporter permease protein	potC	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
k59_162833_2	1417296.U879_03000	0.000107	47.8	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2TQV6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	thiY	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_778485_2	926550.CLDAP_07120	4.26e-33	124.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_130392_1	1121861.KB899925_gene2559	9.49e-21	87.4	COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2U98I@28211|Alphaproteobacteria,2JSWH@204441|Rhodospirillales	204441|Rhodospirillales	M	COG1247 Sortase and related acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_4
k59_1012492_2	1293054.HSACCH_01640	1.53e-23	100.0	2ECQ5@1|root,336MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_686369_1	929713.NIASO_08790	2.56e-39	145.0	COG0526@1|root,COG0526@2|Bacteria,4NKFI@976|Bacteroidetes,1IRSC@117747|Sphingobacteriia	976|Bacteroidetes	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369,Redoxin
k59_686369_2	945713.IALB_2164	2.22e-24	99.0	COG1284@1|root,COG1284@2|Bacteria	2|Bacteria	S	Uncharacterised 5xTM membrane BCR, YitT family COG1284	yvjA	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
k59_164001_1	1163617.SCD_n00468	2.7e-126	372.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_164001_2	1210884.HG799469_gene13937	2.42e-26	117.0	COG1052@1|root,COG1052@2|Bacteria,2J557@203682|Planctomycetes	203682|Planctomycetes	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_164001_3	314607.KB13_1	1.55e-73	229.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30,5.4.2.9	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	-	R00409,R00661	RC00286,RC00287,RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_947575_1	1030157.AFMP01000065_gene1156	2.3e-38	136.0	COG0791@1|root,COG0791@2|Bacteria,1N19W@1224|Proteobacteria,2UD6N@28211|Alphaproteobacteria,2KDA7@204457|Sphingomonadales	204457|Sphingomonadales	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_718981_1	1218084.BBJK01000042_gene3739	3.82e-54	191.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2VMMA@28216|Betaproteobacteria,1K51F@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.3.19,1.5.8.4	ko:K00315,ko:K19191	ko00260,ko00760,ko01100,ko01120,map00260,map00760,map01100,map01120	-	R01565,R10102	RC00060,RC00181,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_33406_1	1267535.KB906767_gene2530	4.51e-30	124.0	COG1501@1|root,COG1501@2|Bacteria,3Y31M@57723|Acidobacteria,2JIBY@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF5110,Gal_mutarotas_2,Glyco_hydro_31
k59_653815_1	493475.GARC_3098	1.1e-16	77.8	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,468EZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
k59_555895_1	1198452.Jab_1c18130	7e-19	85.5	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,472BV@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_7
k59_555895_2	859657.RPSI07_2467	3.18e-52	172.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,1K4BM@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_33412_1	979556.MTES_1282	3.23e-18	89.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4FMJF@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_718996_1	518766.Rmar_1549	4.75e-74	242.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE71@976|Bacteroidetes,1FIUV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	dehydrogenase, E1 component	bfmBAB	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
k59_164027_1	414684.RC1_0287	1.73e-58	196.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,2JQM1@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_425183_2	85643.Tmz1t_3080	3.31e-58	181.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,2KWAV@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_229277_1	83406.HDN1F_01690	9.51e-23	94.0	COG1028@1|root,COG1028@2|Bacteria,1P1U4@1224|Proteobacteria,1RR3M@1236|Gammaproteobacteria,1J55T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_621139_1	665959.HMPREF1013_03119	5.76e-14	79.0	COG1401@1|root,COG2947@1|root,COG1401@2|Bacteria,COG2947@2|Bacteria,1TPIP@1239|Firmicutes,4HBRV@91061|Bacilli,1ZB18@1386|Bacillus	91061|Bacilli	V	AAA domain (dynein-related subfamily)	-	-	-	ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	AAA_5,EVE
k59_490604_1	663610.JQKO01000016_gene1629	1.64e-30	119.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_490604_2	555779.Dthio_PD2105	8.83e-16	79.7	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,43B03@68525|delta/epsilon subdivisions,2X6E6@28221|Deltaproteobacteria,2MH1Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Transposase zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_817108_1	330214.NIDE0012	2.42e-12	63.2	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	fosB2	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_817108_2	653045.Strvi_4705	3.45e-12	69.7	COG2761@1|root,COG2761@2|Bacteria,2GNBC@201174|Actinobacteria	201174|Actinobacteria	Q	Dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_33453_2	1132855.KB913035_gene1127	7.79e-44	147.0	COG4969@1|root,COG4969@2|Bacteria,1N4MN@1224|Proteobacteria,2VVHM@28216|Betaproteobacteria,2KNTC@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Pilin (bacterial filament)	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
k59_327323_1	269482.Bcep1808_2338	3.77e-77	251.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,1K2EF@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_817113_1	1280953.HOC_18184	5.06e-05	44.7	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_817113_2	322710.Avin_32320	3.16e-26	103.0	COG3415@1|root,COG3415@2|Bacteria,1RM6K@1224|Proteobacteria,1ST6Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,HTH_Tnp_IS630
k59_425217_1	314260.PB2503_02032	1.57e-06	50.8	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	peptidase, M13	-	-	3.4.24.71	ko:K01415,ko:K07386	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_164059_2	391626.OAN307_c10150	2.92e-34	125.0	COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,2UD7X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	COG2131 Deoxycytidylate deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
k59_719036_1	864051.BurJ1DRAFT_2756	1.42e-61	211.0	COG1457@1|root,COG4191@1|root,COG1457@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2WI27@28216|Betaproteobacteria,1KPDM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
k59_915026_1	1089550.ATTH01000001_gene528	1.67e-20	96.7	COG0497@1|root,COG0497@2|Bacteria,4NE3I@976|Bacteroidetes,1FIR2@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_229307_1	1123354.AUDR01000013_gene579	1.06e-145	427.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,1KRCT@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_882216_1	1089544.KB912942_gene3587	2.2e-07	53.1	COG2197@1|root,COG2197@2|Bacteria,2IKET@201174|Actinobacteria,4DXF0@85010|Pseudonocardiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_425231_1	439235.Dalk_3628	2.22e-16	78.2	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MIHR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_425231_2	1123376.AUIU01000011_gene1098	7.44e-31	115.0	COG0712@1|root,COG0712@2|Bacteria,3J1BY@40117|Nitrospirae	40117|Nitrospirae	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_686460_1	1123367.C666_13945	1.64e-80	256.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,2KV4F@206389|Rhodocyclales	206389|Rhodocyclales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_229315_1	460265.Mnod_2977	3.19e-06	53.9	COG3385@1|root,COG3385@2|Bacteria,1RK5C@1224|Proteobacteria,2UNB7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_523249_1	1128421.JAGA01000003_gene3437	1.21e-75	243.0	COG0318@1|root,COG0318@2|Bacteria,2NPH9@2323|unclassified Bacteria	2|Bacteria	IQ	COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	alkK	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_164074_1	545264.KB898747_gene384	1.29e-19	85.9	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1WX7Z@135613|Chromatiales	135613|Chromatiales	HJ	Belongs to the RimK family	rimK	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_164077_1	998674.ATTE01000001_gene1169	3.44e-85	261.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RR9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_621197_2	266264.Rmet_3384	9.24e-31	112.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR7N@28216|Betaproteobacteria,1KH6M@119060|Burkholderiaceae	28216|Betaproteobacteria	U	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_588571_1	661478.OP10G_0980	8.89e-52	185.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HD,HD_5
k59_425244_1	176299.Atu1817	3.09e-81	254.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria,4B7S8@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_783929_1	1097668.BYI23_A018690	3.28e-86	270.0	COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,2VIR7@28216|Betaproteobacteria,1JZWT@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Lytic transglycosylase	mltD	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_131429_1	983920.Y88_2747	1.79e-30	108.0	COG1773@1|root,COG1773@2|Bacteria,1N6TQ@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the rubredoxin family	hupI	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
k59_131429_2	1123355.JHYO01000002_gene1263	5.71e-45	154.0	COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2TV0P@28211|Alphaproteobacteria,36XXV@31993|Methylocystaceae	28211|Alphaproteobacteria	C	HupH hydrogenase expression protein, C-terminal conserved region	hupH	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
k59_719063_1	293613.A1E_02155	8.63e-15	77.0	COG0477@1|root,COG0477@2|Bacteria,1NTFK@1224|Proteobacteria,2UQK2@28211|Alphaproteobacteria,47G1P@766|Rickettsiales	766|Rickettsiales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_588573_1	722419.PH505_af00700	6.17e-23	101.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,2Q10E@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	iEcSMS35_1347.EcSMS35_0678,iSbBS512_1146.SbBS512_E0590	CN_hydrolase
k59_588573_2	85643.Tmz1t_0868	3.37e-94	282.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,2KV4Z@206389|Rhodocyclales	206389|Rhodocyclales	P	Mg2 and Co2 transporter CorC	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_523265_1	748247.AZKH_0333	4.99e-96	287.0	COG3245@1|root,COG3245@2|Bacteria,1RCEB@1224|Proteobacteria,2VQIB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3
k59_262085_1	396588.Tgr7_1460	3.58e-79	253.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1WW9D@135613|Chromatiales	135613|Chromatiales	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_915072_1	309801.trd_0653	1.84e-14	79.0	COG1560@1|root,COG1560@2|Bacteria,2G7BA@200795|Chloroflexi,27Y7M@189775|Thermomicrobia	189775|Thermomicrobia	M	Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241,2.3.1.265	ko:K02517,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_425262_2	1123487.KB892846_gene561	7.3e-27	110.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,2KUEB@206389|Rhodocyclales	206389|Rhodocyclales	T	Periplasmic domain of Sensor histidine kinase RisS	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,RisS_PPD
k59_588603_1	1366050.N234_19250	2.57e-88	290.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_164116_1	1121405.dsmv_2551	5.97e-59	205.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2MI1W@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
k59_980303_1	1229909.NSED_02630	1.86e-115	339.0	COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_98832_1	748247.AZKH_1038	1.63e-95	307.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KVC4@206389|Rhodocyclales	206389|Rhodocyclales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_490705_1	330214.NIDE1707	2.3e-58	199.0	COG0013@1|root,COG0013@2|Bacteria,3J0D3@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_882261_1	879212.DespoDRAFT_01776	4.66e-50	169.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2MI9K@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Gtr1/RagA G protein conserved region	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
k59_915088_1	1288494.EBAPG3_28890	1.02e-91	282.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,371V8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall hydrolase autolysin	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_915088_2	1005994.GTGU_01209	1.26e-33	122.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,1S9I3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	nuclease	Z012_04225	GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	Excalibur,SNase
k59_915088_3	864051.BurJ1DRAFT_0811	1.81e-51	174.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,1KK1R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_164122_1	568706.BN118_0361	1.44e-29	117.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,3T1PN@506|Alcaligenaceae	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_67250_2	2340.JV46_06530	7.82e-37	132.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1J4T6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	riboflavin synthase, alpha	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_491750_1	483219.LILAB_25690	4.84e-82	254.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2YU09@29|Myxococcales	28221|Deltaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2261	ATP-grasp_2,Ligase_CoA
k59_1790_2	945713.IALB_2712	4.68e-56	178.0	COG3613@1|root,COG3613@2|Bacteria	2|Bacteria	F	nucleoside 2-deoxyribosyltransferase	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009123,GO:0009125,GO:0009159,GO:0009162,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070694,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
k59_1790_3	1191523.MROS_0374	2.35e-30	116.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	bshA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_762548_1	945713.IALB_1037	2.89e-92	287.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria	2|Bacteria	E	Formiminotransferase domain	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
k59_667716_1	1132855.KB913035_gene506	2.04e-48	165.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,2KMD1@206350|Nitrosomonadales	206350|Nitrosomonadales	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
k59_993126_1	323848.Nmul_A2720	1.63e-57	183.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2VJ98@28216|Betaproteobacteria,3724S@32003|Nitrosomonadales	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_993126_2	1288494.EBAPG3_9160	2.38e-77	234.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2VQ3U@28216|Betaproteobacteria,3733Z@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_993126_3	977880.RALTA_A0859	2.8e-10	59.7	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2VIA5@28216|Betaproteobacteria,1K1P4@119060|Burkholderiaceae	28216|Betaproteobacteria	K	transcriptional regulatory protein	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_667717_1	314265.R2601_10299	4.21e-54	172.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_667717_2	1197906.CAJQ02000043_gene2018	1.32e-28	108.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,3JS1E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	leucine-zipper of insertion element IS481	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,rve,rve_3
k59_177587_1	95619.PM1_0217770	4.87e-49	173.0	COG3566@1|root,COG3566@2|Bacteria,1QWCX@1224|Proteobacteria,1RZS8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2213
k59_894754_1	637910.ROD_20851	1.58e-102	310.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,1S087@1236|Gammaproteobacteria,3WZBR@544|Citrobacter	1236|Gammaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1019010_1	1150599.MPHLEI_02793	7.22e-24	105.0	COG3209@1|root,COG3209@2|Bacteria,2I60K@201174|Actinobacteria,2375A@1762|Mycobacteriaceae	201174|Actinobacteria	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,RCC1_2
k59_504419_1	1280946.HY29_01025	5.91e-06	54.3	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U3G1@28211|Alphaproteobacteria,43Z59@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3,CIA30
k59_961417_1	1095769.CAHF01000014_gene2840	1.75e-126	368.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2VIBX@28216|Betaproteobacteria,4729M@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_700538_1	1123487.KB892836_gene3234	1.91e-101	320.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VJK5@28216|Betaproteobacteria,2KY51@206389|Rhodocyclales	206389|Rhodocyclales	G	pyruvate phosphate dikinase	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_504423_1	1121127.JAFA01000018_gene161	3.19e-37	127.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2VTZ8@28216|Betaproteobacteria,1K9NF@119060|Burkholderiaceae	28216|Betaproteobacteria	L	HMMPfam hit to PF00665, Integrase core domain, score 4.5e-41	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_504423_2	290512.Paes_2312	6.04e-33	122.0	COG2801@1|root,COG2801@2|Bacteria,1FF2V@1090|Chlorobi	1090|Chlorobi	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve_3
k59_80006_1	765910.MARPU_14045	1.1e-14	76.3	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1WWRZ@135613|Chromatiales	135613|Chromatiales	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_80006_2	264732.Moth_2019	5.13e-26	100.0	COG1917@1|root,COG1917@2|Bacteria,1V6IB@1239|Firmicutes,24JTU@186801|Clostridia,42H4U@68295|Thermoanaerobacterales	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_634388_1	748247.AZKH_1449	5.47e-53	187.0	COG2202@1|root,COG3452@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3452@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,2KUQP@206389|Rhodocyclales	206389|Rhodocyclales	T	COG2202 FOG PAS PAC domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
k59_273613_1	443143.GM18_0590	3.14e-16	83.2	COG3880@1|root,COG3880@2|Bacteria	2|Bacteria	E	PFAM UvrB UvrC protein	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K08999,ko:K19405,ko:K19411	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	Cytochrom_CIII,Cytochrome_C7,UVR
k59_700543_1	497321.C664_18242	1.46e-68	216.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,2KUT2@206389|Rhodocyclales	206389|Rhodocyclales	K	RNA polymerase sigma	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_732935_1	1452718.JBOY01000054_gene1977	8.73e-45	161.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7
k59_372840_1	1247963.JPHU01000005_gene423	1.5e-18	86.7	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_372840_2	1123355.JHYO01000026_gene257	6.06e-09	57.8	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0768 cell division protein FtsI penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_928855_1	984262.SGRA_3394	3.08e-48	174.0	COG0855@1|root,COG0855@2|Bacteria,4NE3P@976|Bacteroidetes,1IPGC@117747|Sphingobacteriia	976|Bacteroidetes	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_831048_1	743719.PaelaDRAFT_0873	2.86e-24	100.0	COG0702@1|root,COG0702@2|Bacteria,1TXTH@1239|Firmicutes,4I6VU@91061|Bacilli,26V7T@186822|Paenibacillaceae	91061|Bacilli	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_831048_2	37919.EP51_22610	7.42e-22	95.5	COG1309@1|root,COG1309@2|Bacteria,2GJQY@201174|Actinobacteria,4G062@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_145032_1	1408473.JHXO01000004_gene77	5.38e-32	121.0	COG1014@1|root,COG1014@2|Bacteria,4NGN3@976|Bacteroidetes,2FP78@200643|Bacteroidia	976|Bacteroidetes	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
k59_862627_1	323848.Nmul_A0190	1.64e-55	180.0	COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria,3739N@32003|Nitrosomonadales	28216|Betaproteobacteria	S	signal sequence binding	sco1	-	-	-	-	-	-	-	-	-	-	-	-
k59_240358_1	330214.NIDE3276	5.06e-111	335.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,PqqD,Radical_SAM
k59_531334_1	86416.Clopa_0944	9.77e-59	192.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,36GQU@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
k59_177617_1	1235279.C772_00778	5.15e-13	73.9	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4HAFP@91061|Bacilli,26DHC@186818|Planococcaceae	91061|Bacilli	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	swrC	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_14682_1	864073.HFRIS_016030	6.66e-31	115.0	COG0741@1|root,COG0741@2|Bacteria,1MZU4@1224|Proteobacteria,2VU6M@28216|Betaproteobacteria	28216|Betaproteobacteria	M	lytic transglycosylase	iagB	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_273624_1	420662.Mpe_A3158	9.72e-67	211.0	COG0454@1|root,COG0456@2|Bacteria,1QUZC@1224|Proteobacteria,2WGMV@28216|Betaproteobacteria,1KPD9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_3
k59_667766_1	1038869.AXAN01000037_gene1577	1.97e-08	54.7	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,1JZZ1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_667766_2	395494.Galf_1784	1.03e-49	166.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,44VX8@713636|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM outer membrane chaperone Skp (OmpH)	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_961451_1	187272.Mlg_1558	4.81e-25	101.0	COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,1TKD5@1236|Gammaproteobacteria,1X1ZA@135613|Chromatiales	135613|Chromatiales	C	plastoquinol--plastocyanin reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_961451_2	1232410.KI421417_gene2707	1.37e-22	94.4	COG2032@1|root,COG2032@2|Bacteria,1N26J@1224|Proteobacteria,43B8H@68525|delta/epsilon subdivisions,2X6MV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
k59_700571_1	981369.JQMJ01000004_gene3827	2.9e-16	83.2	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,2NHDP@228398|Streptacidiphilus	201174|Actinobacteria	C	ATP-grasp domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_14692_1	1121937.AUHJ01000021_gene1432	4.19e-82	252.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,46BKC@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_372871_1	640081.Dsui_0972	8.65e-18	82.8	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,2KV95@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_634427_1	1121405.dsmv_2738	5.06e-85	271.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_14697_2	1123276.KB893301_gene4199	0.000508	43.9	2DZQQ@1|root,336S7@2|Bacteria,4NV3W@976|Bacteroidetes,47SKU@768503|Cytophagia	976|Bacteroidetes	S	Transmembrane family 220, helix	-	-	-	-	-	-	-	-	-	-	-	-	TMEM220
k59_700584_3	1121033.AUCF01000043_gene3675	1.06e-06	52.0	COG0784@1|root,COG0784@2|Bacteria,1N1ZB@1224|Proteobacteria,2UC57@28211|Alphaproteobacteria,2JWTU@204441|Rhodospirillales	204441|Rhodospirillales	T	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
k59_273631_2	1288494.EBAPG3_510	2.11e-29	118.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,372IA@32003|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter transmembrane region	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_307156_1	1266925.JHVX01000005_gene1928	3.66e-100	309.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,3721Z@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_468816_1	880073.Calab_3333	1.81e-20	95.1	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_928912_1	1278073.MYSTI_03539	4.61e-92	300.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_602061_1	760117.JN27_09910	2.75e-118	348.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2VJ31@28216|Betaproteobacteria,474PP@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_788338_1	1123368.AUIS01000019_gene1206	2.15e-44	159.0	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,1RPG9@1236|Gammaproteobacteria,2NCE0@225057|Acidithiobacillales	225057|Acidithiobacillales	T	His Kinase A (phospho-acceptor) domain	-	-	2.7.13.3	ko:K02484,ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_602062_1	693661.Arcve_1580	1.26e-36	140.0	COG0038@1|root,arCOG02569@2157|Archaea,2XW6N@28890|Euryarchaeota,2461Y@183980|Archaeoglobi	183980|Archaeoglobi	P	Chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_145090_1	580332.Slit_0475	9.86e-110	329.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,44VK2@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_570304_1	383372.Rcas_3465	2.45e-50	184.0	COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi	200795|Chloroflexi	L	sptr a7nhu5	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_668391_1	204773.HEAR0343	2.65e-220	614.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,472FC@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_993739_1	1123367.C666_05545	5.24e-63	216.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_469233_1	1095769.CAHF01000005_gene1469	1.63e-85	271.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria	28216|Betaproteobacteria	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_831713_1	159087.Daro_1306	1.08e-06	47.4	COG2963@1|root,COG2963@2|Bacteria,1N06K@1224|Proteobacteria,2VUF3@28216|Betaproteobacteria,2KZ7Q@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_831713_2	288000.BBta_1458	9.54e-68	213.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,3JW35@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_929495_1	1279017.AQYJ01000021_gene2884	1e-33	125.0	COG3637@1|root,COG3637@2|Bacteria,1R3QN@1224|Proteobacteria,1RY3J@1236|Gammaproteobacteria,467AR@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_145657_1	1122247.C731_2954	1.35e-18	96.7	COG0209@1|root,COG0209@2|Bacteria,2IC1H@201174|Actinobacteria,23CT3@1762|Mycobacteriaceae	201174|Actinobacteria	F	Ribonucleotide reductase, barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_red_lgC
k59_240845_1	398512.JQKC01000030_gene4396	7.7e-30	114.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,3WHWU@541000|Ruminococcaceae	186801|Clostridia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
k59_240845_2	330214.NIDE0531	1.82e-60	196.0	COG0240@1|root,COG0240@2|Bacteria,3J0GP@40117|Nitrospirae	40117|Nitrospirae	I	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_531622_1	1158292.JPOE01000005_gene1001	8.13e-104	310.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
k59_733608_1	436308.Nmar_0090	2.89e-13	68.6	COG1131@1|root,arCOG00194@2157|Archaea,41TB8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_733608_2	436308.Nmar_0091	7.62e-152	430.0	COG0842@1|root,arCOG01467@2157|Archaea,41SH0@651137|Thaumarchaeota	651137|Thaumarchaeota	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_505051_1	76114.ebA837	3.45e-78	234.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2VQ5I@28216|Betaproteobacteria,2KWAF@206389|Rhodocyclales	206389|Rhodocyclales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_505051_2	221288.JH992901_gene802	9.47e-27	107.0	COG1062@1|root,COG1062@2|Bacteria,1G2S4@1117|Cyanobacteria,1JHQU@1189|Stigonemataceae	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	frmA	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_307686_1	96561.Dole_0664	1.56e-73	225.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,2MNC8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_763063_1	1366050.N234_08025	1.15e-12	68.6	COG3181@1|root,COG3181@2|Bacteria,1NS90@1224|Proteobacteria,2VZ84@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_763063_2	5059.CADAFLAP00000712	7.02e-39	149.0	COG2159@1|root,KOG4245@2759|Eukaryota,38BZU@33154|Opisthokonta,3NWQ1@4751|Fungi,3QRDS@4890|Ascomycota	4751|Fungi	S	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_788542_1	1408473.JHXO01000011_gene3177	6.18e-128	379.0	COG3875@1|root,COG3875@2|Bacteria,4NI4Z@976|Bacteroidetes,2FQM8@200643|Bacteroidia	976|Bacteroidetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_145661_1	1163617.SCD_n02941	4.32e-136	395.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_145661_2	85643.Tmz1t_0835	9.69e-13	67.8	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,2KWD2@206389|Rhodocyclales	206389|Rhodocyclales	NU	fimbrial biogenesis protein PilN	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_178225_1	395964.KE386496_gene2959	4.58e-67	229.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,3N9RR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	DNA polymerase alpha chain like domain	dnaE	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_245988_1	1123392.AQWL01000003_gene502	2.43e-103	307.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,1KRBG@119069|Hydrogenophilales	119069|Hydrogenophilales	J	tRNA synthetases class II core domain (F)	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_968303_1	682795.AciX8_4367	4.47e-60	196.0	COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria,2JIT2@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_511168_1	1469613.JT55_02130	3.18e-92	291.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,3FCUB@34008|Rhodovulum	28211|Alphaproteobacteria	T	PEP-utilising enzyme, N-terminal	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_313165_1	1163617.SCD_n00803	3.28e-78	243.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2VQNY@28216|Betaproteobacteria	28216|Betaproteobacteria	H	lipoate-protein ligase A	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_608628_2	1298598.JCM21714_577	2.03e-05	46.6	COG4786@1|root,COG4786@2|Bacteria,1TRA2@1239|Firmicutes,4HBNB@91061|Bacilli,46ZQF@74385|Gracilibacillus	91061|Bacilli	N	Flagellar basal body rod FlgEFG protein C-terminal	flgG	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
k59_444578_1	1218076.BAYB01000037_gene5467	2.99e-12	65.9	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1K1R9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_900999_1	234267.Acid_3592	7.91e-59	187.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	MA20_23315	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_707458_1	391615.ABSJ01000042_gene2272	3.81e-153	441.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1J8WH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	iYL1228.KPN_02462	AdoHcyase,AdoHcyase_NAD
k59_869339_1	580332.Slit_0035	3.95e-27	104.0	COG2890@1|root,COG2890@2|Bacteria,1R0WI@1224|Proteobacteria	1224|Proteobacteria	J	TIGRFAM methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
k59_869339_2	323848.Nmul_A0221	1.12e-38	139.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,371VZ@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metXS	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_837990_1	670307.HYPDE_23753	3.31e-81	258.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,3N64U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_184056_1	998674.ATTE01000001_gene4298	2.4e-17	77.4	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,460ID@72273|Thiotrichales	72273|Thiotrichales	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_184056_2	395493.BegalDRAFT_2608	8.11e-49	158.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,460WC@72273|Thiotrichales	72273|Thiotrichales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_53343_1	243365.CV_0440	1.35e-85	267.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,2KPJK@206351|Neisseriales	206351|Neisseriales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_119110_1	497964.CfE428DRAFT_5992	4.57e-116	361.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
k59_86892_1	1249627.D779_2584	2.3e-45	151.0	COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,1SYIJ@1236|Gammaproteobacteria,1WYYE@135613|Chromatiales	135613|Chromatiales	K	MerR, DNA binding	-	-	-	ko:K19591	-	M00769	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	MerR,MerR-DNA-bind
k59_21439_1	323850.Shew_0984	7.53e-98	296.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQX@1236|Gammaproteobacteria,2QCYP@267890|Shewanellaceae	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_790974_1	717785.HYPMC_3758	4.24e-70	216.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,3N8QM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_768423_1	1123504.JQKD01000030_gene4608	1.9e-05	45.8	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,4AAE7@80864|Comamonadaceae	28216|Betaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_768423_2	1265502.KB905968_gene1266	2.64e-127	367.0	COG1349@1|root,COG1349@2|Bacteria,1MUJG@1224|Proteobacteria,2VHRN@28216|Betaproteobacteria,4A9TT@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein DeoR	glpR	-	-	ko:K02444	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
k59_444620_1	1120963.KB894514_gene389	3.7e-23	107.0	COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,1S4YH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
k59_935753_1	439235.Dalk_0069	6.81e-30	116.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MTH@68525|delta/epsilon subdivisions,2WJQY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_935753_2	1397527.Q670_10105	1.52e-26	104.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,1RQU2@1236|Gammaproteobacteria,1XH78@135619|Oceanospirillales	135619|Oceanospirillales	E	Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_409310_1	1123376.AUIU01000012_gene1618	7.23e-99	318.0	COG0085@1|root,COG0085@2|Bacteria,3J0CW@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_379259_1	644282.Deba_1935	2.03e-07	52.8	2E47B@1|root,32Z37@2|Bacteria,1NC7T@1224|Proteobacteria,42VYF@68525|delta/epsilon subdivisions,2WRN2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_768424_1	323848.Nmul_A2288	1.61e-211	594.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,372EA@32003|Nitrosomonadales	28216|Betaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360	5.4.4.3,6.3.1.2	ko:K01915,ko:K20712	ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253,R06988,R09284	RC00010,RC01754,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_768424_2	1454004.AW11_03366	9.08e-36	125.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VR3P@28216|Betaproteobacteria,1KQY4@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_768426_1	338963.Pcar_0657	3.95e-78	250.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,43RYF@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_707522_1	945713.IALB_0288	6.05e-74	244.0	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	1.1.1.3,1.4.1.2,2.7.7.19,2.7.7.42,2.7.7.59,2.7.7.72,2.7.7.89	ko:K00003,ko:K00970,ko:K00974,ko:K00982,ko:K00990,ko:K06950,ko:K15371	ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,ko03013,ko03018,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020,map03013,map03018	M00017,M00018	R00243,R01773,R01775,R09382,R09383,R09384,R09386	RC00006,RC00078,RC00087,RC02799	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2,PolyA_pol,PolyA_pol_RNAbd
k59_935771_1	582744.Msip34_0246	7.59e-84	255.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,2KKSM@206350|Nitrosomonadales	206350|Nitrosomonadales	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_999790_1	880073.Calab_3190	4.3e-85	265.0	COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufB	sufB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078	UPF0051
k59_935772_1	1191523.MROS_0324	2.17e-18	78.2	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup_1	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_935772_2	153721.MYP_3763	2.94e-65	204.0	COG2207@1|root,COG2207@2|Bacteria,4NM5G@976|Bacteroidetes,47XNC@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
k59_968404_1	1415166.NONO_c03460	9.86e-53	179.0	28KAT@1|root,2Z9XX@2|Bacteria,2GNVW@201174|Actinobacteria,4FUSP@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_999792_2	1232410.KI421421_gene3683	5e-25	103.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,43U6N@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_151811_1	323259.Mhun_2659	6.51e-11	68.2	COG0683@1|root,arCOG01021@2157|Archaea	2157|Archaea	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ANF_receptor,Peripla_BP_6
k59_768434_1	234267.Acid_2554	1.94e-58	197.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_869408_1	28072.Nos7524_4296	1.55e-90	281.0	COG3547@1|root,COG3547@2|Bacteria,1GA7N@1117|Cyanobacteria,1HTM7@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_576538_1	1121022.ABENE_18425	8.03e-32	115.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_838066_1	266264.Rmet_5695	1.34e-49	166.0	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2VM81@28216|Betaproteobacteria	28216|Betaproteobacteria	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_838066_2	479432.Sros_7603	1.14e-22	95.5	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,4EIAJ@85012|Streptosporangiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
k59_86937_1	526225.Gobs_2522	1.32e-74	231.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4ERK6@85013|Frankiales	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_707542_1	234267.Acid_4539	1.99e-75	246.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,3Y6VT@57723|Acidobacteria	57723|Acidobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_576550_1	225849.swp_2777	9.09e-09	56.6	COG0517@1|root,COG0517@2|Bacteria,1RKPE@1224|Proteobacteria,1S6X7@1236|Gammaproteobacteria,2QBZ2@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_314156_1	314266.SKA58_16353	1.93e-08	56.2	COG1028@1|root,COG1028@2|Bacteria,1R4H4@1224|Proteobacteria,2U2GZ@28211|Alphaproteobacteria,2K1TB@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_445632_1	945713.IALB_2055	1.86e-42	148.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
k59_445632_2	742726.HMPREF9448_01621	1.6e-05	48.1	COG2304@1|root,COG2304@2|Bacteria,4NF7Y@976|Bacteroidetes,2FN4B@200643|Bacteroidia,22WPY@171551|Porphyromonadaceae	976|Bacteroidetes	S	Von Willebrand factor type A domain	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
k59_870429_1	587753.EY04_16700	1.55e-29	119.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RY4R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Dehydrogenase	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_534992_1	667632.KB890173_gene3816	3.73e-48	159.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2VU5R@28216|Betaproteobacteria,1K7A9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
k59_642051_1	330214.NIDE0726	2.87e-91	294.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_475288_1	330214.NIDE0322	3.44e-76	240.0	COG4398@1|root,COG4398@2|Bacteria	2|Bacteria	E	FIST C domain	-	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
k59_475288_2	1173023.KE650771_gene4392	2.33e-17	77.8	COG0545@1|root,COG0545@2|Bacteria,1G5T1@1117|Cyanobacteria,1JIIN@1189|Stigonemataceae	1117|Cyanobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	fkpA	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_769360_1	713587.THITH_07390	1.62e-84	276.0	COG0457@1|root,COG0457@2|Bacteria,1QZTW@1224|Proteobacteria,1T54Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_217513_1	1232437.KL662031_gene2543	5.39e-97	292.0	COG2367@1|root,COG2367@2|Bacteria,1R6KF@1224|Proteobacteria,42YYI@68525|delta/epsilon subdivisions,2WTQR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_88013_1	314278.NB231_10403	2.88e-59	196.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria,1WWU8@135613|Chromatiales	135613|Chromatiales	S	SpoVR family	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
k59_708608_1	1131553.JIBI01000039_gene1942	1.4e-57	194.0	COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,2VPGJ@28216|Betaproteobacteria,3728R@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA2	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_120226_2	948106.AWZT01000035_gene2422	2.73e-62	198.0	COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,2VMIW@28216|Betaproteobacteria,1K1ZR@119060|Burkholderiaceae	28216|Betaproteobacteria	U	UPF0056 inner membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_609786_1	756067.MicvaDRAFT_3420	6.66e-16	83.2	COG0823@1|root,COG2931@1|root,COG0823@2|Bacteria,COG2931@2|Bacteria,1G554@1117|Cyanobacteria,1HF7I@1150|Oscillatoriales	1117|Cyanobacteria	QU	PFAM Haemolysin-type calcium-binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PD40
k59_88023_1	1121405.dsmv_3106	3.76e-123	362.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2MHKY@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_902083_1	948106.AWZT01000014_gene625	2.43e-55	195.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1K1YU@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_22511_1	1255043.TVNIR_0569	4.11e-83	269.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1X0FJ@135613|Chromatiales	135613|Chromatiales	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
k59_870453_1	1121035.AUCH01000002_gene1690	1.05e-42	151.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,2KUWH@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_870453_2	1128421.JAGA01000003_gene3441	1.51e-57	191.0	COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria	2|Bacteria	E	Arginosuccinate synthase	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
k59_577627_2	880072.Desac_0390	1.8e-25	101.0	COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,42VVN@68525|delta/epsilon subdivisions,2WRTH@28221|Deltaproteobacteria,2MS9X@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
k59_54376_1	573061.Clocel_4319	5.2e-36	134.0	COG2334@1|root,COG2334@2|Bacteria,1TSRC@1239|Firmicutes,25DKM@186801|Clostridia,36IAZ@31979|Clostridiaceae	186801|Clostridia	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_475301_1	1415779.JOMH01000001_gene1123	5.44e-100	313.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,1X4B6@135614|Xanthomonadales	135614|Xanthomonadales	O	peptidase	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_512342_1	933262.AXAM01000010_gene1385	2.26e-29	112.0	COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WR6T@28221|Deltaproteobacteria,2MK1E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_512342_2	933262.AXAM01000010_gene1386	2.12e-18	81.6	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MJKI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_675831_1	760117.JN27_05640	2.92e-85	273.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,4736M@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1000795_1	1348635.BBJY01000007_gene166	7.54e-65	213.0	2AG8V@1|root,316E7@2|Bacteria,1PXEQ@1224|Proteobacteria,1TIV5@1236|Gammaproteobacteria,1XZQY@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1000795_2	1123399.AQVE01000018_gene3348	1.39e-07	55.8	2EX69@1|root,33QH8@2|Bacteria,1NSKF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_969540_1	460265.Mnod_0225	3.8e-06	47.8	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TSCF@28211|Alphaproteobacteria,1JXM2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	MA20_09930	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_969540_2	985054.JQEZ01000003_gene1231	2.75e-54	184.0	COG4177@1|root,COG4177@2|Bacteria,1MZDJ@1224|Proteobacteria,2TRYJ@28211|Alphaproteobacteria,4NCP1@97050|Ruegeria	28211|Alphaproteobacteria	P	Branched-chain amino acid ABC transporter, permease protein	MA20_23495	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_22526_1	765911.Thivi_0061	6.97e-94	293.0	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_577642_1	305700.B447_17701	1.6e-84	265.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,2KUI1@206389|Rhodocyclales	206389|Rhodocyclales	C	Glycolate oxidase subunit GlcD	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1022728_1	292415.Tbd_0095	1.02e-77	247.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,1KRG4@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_741047_2	1357423.S5MV60_9CAUD	3.77e-33	144.0	4QBUC@10239|Viruses,4QVRG@35237|dsDNA viruses  no RNA stage,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_902099_1	1123501.KB902297_gene3631	0.000571	43.5	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_902099_2	1394178.AWOO02000015_gene7084	3e-42	150.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_58721_2	945713.IALB_1732	3.66e-54	179.0	COG0142@1|root,COG0142@2|Bacteria	2|Bacteria	H	isoprenoid biosynthetic process	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_517020_1	393595.ABO_0383	3.35e-117	345.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1XH22@135619|Oceanospirillales	135619|Oceanospirillales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_843944_1	399795.CtesDRAFT_PD0568	9.72e-75	240.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4A9SZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_582396_1	323097.Nham_3328	1.7e-21	102.0	COG5301@1|root,COG5301@2|Bacteria,1N6XX@1224|Proteobacteria,2USJX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	cellulose 1,4-beta-cellobiosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_58726_1	330214.NIDE4173	2.99e-77	248.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
k59_27068_1	631454.N177_3039	8.11e-49	173.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,1JNY6@119043|Rhodobiaceae	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_614259_1	1297569.MESS2_80069	1.1e-64	214.0	COG5598@1|root,COG5598@2|Bacteria,1MX73@1224|Proteobacteria,2TS1M@28211|Alphaproteobacteria,43R7W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
k59_680565_1	1123376.AUIU01000016_gene231	8.32e-84	267.0	COG5002@1|root,COG5002@2|Bacteria,3J10G@40117|Nitrospirae	40117|Nitrospirae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_58734_1	977880.RALTA_A2364	1e-106	322.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,1K10P@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_941559_1	436308.Nmar_0191	2.71e-34	117.0	arCOG08759@1|root,arCOG08759@2157|Archaea,41T9Q@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_941559_2	436308.Nmar_0192	2.58e-44	151.0	COG0115@1|root,arCOG02297@2157|Archaea,41SD5@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_352962_1	1120999.JONM01000005_gene3821	9.13e-74	234.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,2KPPM@206351|Neisseriales	206351|Neisseriales	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_221919_1	330214.NIDE1018	2.52e-124	367.0	COG1530@1|root,COG1530@2|Bacteria,3J0DK@40117|Nitrospirae	40117|Nitrospirae	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
k59_58742_1	247634.GPB2148_943	1.7e-47	158.0	COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,1J6CJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	s cog2930	CT2216	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_713341_1	580332.Slit_2409	3e-56	189.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,44V0Y@713636|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM permease YjgP YjgQ family protein	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_58744_3	573370.DMR_01690	5.54e-05	43.5	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MGUH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_843979_1	498211.CJA_2465	5.43e-24	96.3	COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1S5GE@1236|Gammaproteobacteria,1FHCB@10|Cellvibrio	1236|Gammaproteobacteria	L	Bacterial DNA-binding protein	VL23_14575	-	-	-	-	-	-	-	-	-	-	-	Bac_DNA_binding
k59_92746_1	298654.FraEuI1c_6002	4.31e-56	188.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,4EUN3@85013|Frankiales	201174|Actinobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_517061_1	243233.MCA1084	8.73e-35	134.0	2C8FN@1|root,2ZBER@2|Bacteria,1RK02@1224|Proteobacteria,1T0KH@1236|Gammaproteobacteria,1XEUA@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_874919_1	589865.DaAHT2_1468	7.17e-31	118.0	COG1150@1|root,COG2181@1|root,COG1150@2|Bacteria,COG2181@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	qmoC	-	-	ko:K16887	-	-	-	-	ko00000	-	-	-	Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam
k59_874919_2	693661.Arcve_1563	3.18e-34	131.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02475@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	28890|Euryarchaeota	C	Heterodisulfide reductase subunit A and related polyferredoxins	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16886	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_4,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
k59_479217_1	69279.BG36_00785	3.94e-10	61.2	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U7C6@28211|Alphaproteobacteria,43JMG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	chaC	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
k59_92760_1	580332.Slit_2231	5.3e-47	158.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2VMD6@28216|Betaproteobacteria,44VGQ@713636|Nitrosomonadales	28216|Betaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_844000_1	521674.Plim_1157	5.56e-24	105.0	COG2373@1|root,COG2373@2|Bacteria,2IWRT@203682|Planctomycetes	203682|Planctomycetes	S	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
k59_384535_1	643867.Ftrac_0097	8.43e-24	97.4	COG1522@1|root,COG1522@2|Bacteria,4NNH2@976|Bacteroidetes,47PFB@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix ASNC type	-	-	-	ko:K03719,ko:K05800	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
k59_124737_1	93220.LV28_20670	8.93e-105	313.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2VKD6@28216|Betaproteobacteria,1K2MR@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase mutator type	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_251011_1	339670.Bamb_0834	2.12e-71	225.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,1K2A5@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_318346_1	903818.KI912269_gene243	1.19e-05	46.2	COG0481@1|root,COG0481@2|Bacteria,3Y3EX@57723|Acidobacteria	57723|Acidobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_318346_2	330214.NIDE2552	2.61e-61	196.0	COG0681@1|root,COG0681@2|Bacteria,3J0IP@40117|Nitrospirae	40117|Nitrospirae	U	Signal peptidase, peptidase S26	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
k59_222864_2	330214.NIDE2087	1.11e-10	61.2	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,TPR_16,TPR_8
k59_222864_3	330214.NIDE2086	6.94e-17	80.5	COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae	40117|Nitrospirae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_251763_1	1123371.ATXH01000008_gene246	1.75e-44	149.0	COG1528@1|root,COG1528@2|Bacteria,2GGRA@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Ferritin-like domain	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
k59_647551_2	402626.Rpic_2387	3.65e-28	113.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,1K2K5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_942544_1	710685.MycrhN_5980	3.28e-19	92.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,2330E@1762|Mycobacteriaceae	201174|Actinobacteria	GM	sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
k59_319193_1	1349767.GJA_4096	6.79e-09	56.2	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,4727Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the ompA family	ompA	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
k59_319193_2	375286.mma_2403	1.03e-30	122.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,472FR@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_93728_1	1003200.AXXA_23280	4.26e-25	99.4	2C5P4@1|root,3310H@2|Bacteria,1N6V1@1224|Proteobacteria,2VVVI@28216|Betaproteobacteria,3T4VP@506|Alcaligenaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
k59_93728_2	1255043.TVNIR_1179	6.7e-168	478.0	COG1335@1|root,COG1335@2|Bacteria,1RCGZ@1224|Proteobacteria,1SPB0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_158332_1	1442599.JAAN01000033_gene1589	1.87e-24	95.1	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1X8GV@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
k59_746810_1	246196.MSMEI_2095	7.36e-05	53.1	COG5280@1|root,COG5280@2|Bacteria,2I3FN@201174|Actinobacteria,23FB0@1762|Mycobacteriaceae	201174|Actinobacteria	M	Phage-related minor tail protein	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_251776_1	1082931.KKY_1359	4.29e-20	89.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3N6AE@45401|Hyphomicrobiaceae	1224|Proteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	icd	-	1.1.1.41,1.1.1.42,1.1.1.85	ko:K00030,ko:K00031,ko:K00052	ko00020,ko00290,ko00480,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00290,map00480,map00660,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00432,M00535,M00740	R00267,R00268,R00709,R00994,R01899,R04426,R10052	RC00001,RC00084,RC00114,RC00417,RC00626,RC02801,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_251776_2	1192124.LIG30_0614	3.41e-08	54.3	COG0668@1|root,COG0668@2|Bacteria,1MXH4@1224|Proteobacteria,2VM0E@28216|Betaproteobacteria,1K30Q@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_615247_1	640081.Dsui_1407	1.3e-75	239.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,2KUKJ@206389|Rhodocyclales	206389|Rhodocyclales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_518074_1	469595.CSAG_04150	1.37e-49	175.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria,3WY8H@544|Citrobacter	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,rve
k59_415086_2	765913.ThidrDRAFT_2153	3.85e-40	151.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1WWQF@135613|Chromatiales	135613|Chromatiales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_385448_1	1168289.AJKI01000018_gene1993	4.25e-131	383.0	COG3344@1|root,COG3344@2|Bacteria,4NGGU@976|Bacteroidetes,2FWED@200643|Bacteroidia,3XKBZ@558415|Marinilabiliaceae	976|Bacteroidetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,Intron_maturas2,RVT_1
k59_518075_1	330214.NIDE3967	1.92e-75	239.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_681612_1	264732.Moth_1606	1.53e-235	659.0	COG0247@1|root,COG0247@2|Bacteria,1TSC1@1239|Firmicutes,24B10@186801|Clostridia,42FPP@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	hmeD	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_907443_1	330214.NIDE3770	3.95e-26	105.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_907443_2	330214.NIDE3769	5.51e-34	122.0	COG0529@1|root,COG0529@2|Bacteria	2|Bacteria	P	adenylylsulfate kinase activity	cysC	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
k59_793632_1	1048834.TC41_0328	3.57e-13	73.6	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,4HGBZ@91061|Bacilli	91061|Bacilli	T	GAF domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA
k59_793632_2	318167.Sfri_2504	0.0004	43.5	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG3300@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3300@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2J6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	PAS sensor protein	dosP	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0008081,GO:0008144,GO:0008150,GO:0009628,GO:0016787,GO:0016788,GO:0019825,GO:0019826,GO:0020037,GO:0036094,GO:0042578,GO:0043167,GO:0043169,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0070482,GO:0071111,GO:0097159,GO:1901363	3.1.4.52	ko:K13243	-	-	R08991	RC00296	ko00000,ko01000	-	-	iG2583_1286.G2583_1852	CHASE,EAL,GGDEF,HATPase_c,HisKA,MASE1,MHYT,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_190435_1	768671.ThimaDRAFT_0872	2.58e-39	145.0	COG1289@1|root,COG1289@2|Bacteria,1QJEM@1224|Proteobacteria,1SMXK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Aromatic acid exporter family member 1	VPA1578	-	-	-	-	-	-	-	-	-	-	-	FUSC
k59_942577_1	1045855.DSC_08420	2.65e-29	116.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X34J@135614|Xanthomonadales	135614|Xanthomonadales	V	Efflux pump membrane transporter	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_942577_2	316067.Geob_1225	6.51e-25	103.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,43T2U@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
k59_1006155_1	395495.Lcho_1708	3.62e-107	319.0	COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,2VP38@28216|Betaproteobacteria,1KN8D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
k59_647581_1	945713.IALB_0701	9.51e-96	282.0	COG0233@1|root,COG0233@2|Bacteria	2|Bacteria	J	cytoplasmic translational termination	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_251795_1	323848.Nmul_A0564	1.01e-19	88.6	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,371X2@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_251795_2	305900.GV64_04865	2.49e-07	52.8	COG0730@1|root,COG0730@2|Bacteria,1RF06@1224|Proteobacteria,1SG5B@1236|Gammaproteobacteria,1XQKJ@135619|Oceanospirillales	135619|Oceanospirillales	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
k59_1025601_1	935565.JAEM01000042_gene1836	1.9e-27	106.0	COG2030@1|root,COG2030@2|Bacteria,1RCH6@1224|Proteobacteria,2U83M@28211|Alphaproteobacteria,2PXPX@265|Paracoccus	28211|Alphaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_353963_2	395494.Galf_0253	1.21e-48	161.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,44VR2@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
k59_1006168_2	1341181.FLJC2902T_12890	6.88e-07	53.5	COG2197@1|root,COG2197@2|Bacteria,4NKAD@976|Bacteroidetes,1I0S7@117743|Flavobacteriia,2NV3F@237|Flavobacterium	976|Bacteroidetes	KT	LuxR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_125728_1	1000565.METUNv1_03483	2.32e-14	73.2	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,2KUYB@206389|Rhodocyclales	206389|Rhodocyclales	C	COG0569 K transport systems, NAD-binding component	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_125728_2	1131553.JIBI01000071_gene2157	1.02e-107	327.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,3728D@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_907466_1	626418.bglu_1g15450	3.38e-17	89.7	COG0863@1|root,COG0863@2|Bacteria,1MY4G@1224|Proteobacteria,2VQD7@28216|Betaproteobacteria,1KCB7@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_28122_1	945713.IALB_1450	2.12e-97	296.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_253645_2	1500259.JQLD01000001_gene4015	2.75e-23	100.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria,4B9HY@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	von Willebrand factor type A (vWA) domain	MA20_09405	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_776238_1	1499967.BAYZ01000105_gene3494	5.71e-41	145.0	COG4608@1|root,COG4608@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	MA20_20675	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_192453_2	977880.RALTA_A3105	2.03e-50	173.0	COG3181@1|root,COG3181@2|Bacteria,1MVHU@1224|Proteobacteria,2VMFU@28216|Betaproteobacteria,1KCA9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_356041_1	1304880.JAGB01000001_gene256	3.59e-08	56.2	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia	186801|Clostridia	S	PHP domain	trpH	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
k59_356041_2	1121448.DGI_2627	8.78e-06	46.2	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,42RM4@68525|delta/epsilon subdivisions,2WNU8@28221|Deltaproteobacteria,2MBGM@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	SMART Transcription regulator, AsnC-type	nirD	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_909343_1	335541.Swol_1793	1.83e-11	66.6	COG2208@1|root,COG3275@1|root,COG2208@2|Bacteria,COG3275@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia	186801|Clostridia	KT	stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,SpoIIE,cNMP_binding
k59_909343_2	159087.Daro_1992	1.04e-40	143.0	COG2885@1|root,COG2885@2|Bacteria,1MZKA@1224|Proteobacteria,2VU4E@28216|Betaproteobacteria,2KZ0C@206389|Rhodocyclales	206389|Rhodocyclales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_224834_1	1304875.JAFZ01000001_gene859	4.72e-48	165.0	COG4177@1|root,COG4177@2|Bacteria,3TA7K@508458|Synergistetes	508458|Synergistetes	U	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_192462_1	926550.CLDAP_02040	9.7e-60	197.0	COG3385@1|root,COG3385@2|Bacteria,2G7UE@200795|Chloroflexi	200795|Chloroflexi	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_520161_1	639282.DEFDS_2134	7.67e-47	174.0	COG1391@1|root,COG1391@2|Bacteria,2GEZ7@200930|Deferribacteres	200930|Deferribacteres	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	-	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_416959_1	883078.HMPREF9695_03131	4.9e-76	239.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2TRWV@28211|Alphaproteobacteria,3JVAV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_520165_1	1229909.NSED_00920	5.53e-32	122.0	arCOG08635@1|root,arCOG08635@2157|Archaea,41T54@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_520165_2	436308.Nmar_0218	4.69e-21	88.6	COG0120@1|root,arCOG01122@2157|Archaea,41SJE@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Ribose 5-phosphate isomerase	-	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_452960_1	1123501.KB902316_gene3112	1.28e-60	209.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_538976_2	261292.Nit79A3_3395	2.12e-23	95.5	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2VRBU@28216|Betaproteobacteria,3736U@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_977483_1	330214.NIDE0330	1.09e-79	243.0	COG2928@1|root,COG2928@2|Bacteria,3J0R2@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_30122_1	1123501.KB902294_gene3522	5.54e-12	66.6	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_30122_2	1038862.KB893833_gene4656	4.81e-36	135.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2U0X6@28211|Alphaproteobacteria,3JTUV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_481817_1	640081.Dsui_2238	5.14e-63	211.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,2KWWE@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_30123_1	637905.SVI_2935	6.76e-11	67.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N6EM@1224|Proteobacteria,1RWWA@1236|Gammaproteobacteria,2Q9QI@267890|Shewanellaceae	1236|Gammaproteobacteria	M	PFAM OmpA domain protein transmembrane region-containing protein	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,OmpA_membrane
k59_30124_1	227377.CBU_0497	4.48e-13	68.2	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1JDCU@118969|Legionellales	118969|Legionellales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF_2	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_30124_2	713586.KB900536_gene663	2.26e-30	122.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales	135613|Chromatiales	EH	Anthranilate synthase component I	-	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_321099_1	1205753.A989_05447	1.14e-33	130.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales	135614|Xanthomonadales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_321099_2	84531.JMTZ01000006_gene3535	1.86e-11	63.5	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1X48X@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_538979_1	330214.NIDE3255	6.39e-147	445.0	COG0243@1|root,COG0243@2|Bacteria	2|Bacteria	C	molybdopterin cofactor binding	ddhA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.17.99.2,1.7.5.1,1.8.2.4	ko:K00370,ko:K10700,ko:K16964,ko:K17050	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_61723_2	1210046.B277_05978	2e-08	57.4	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4FFG7@85021|Intrasporangiaceae	201174|Actinobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
k59_585670_1	1096769.Pelub83DRAFT_0928	2.49e-06	48.9	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,4BPV6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	yjcG	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	DUF4212,SSF
k59_585670_2	932678.THERU_06755	9.71e-30	108.0	COG4327@1|root,COG4327@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4212)	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	DUF4212,SSF
k59_193414_1	1267005.KB911257_gene642	8.11e-188	547.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2TT4K@28211|Alphaproteobacteria,3N7IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	biosynthesis protein	lpsB2	GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_96804_1	1356852.N008_09070	4.34e-27	110.0	COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47KW1@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,TPR_12,TPR_7,TPR_8
k59_96804_2	1121448.DGI_1873	1.7e-12	70.5	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2M8MZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4,PAS_9,Response_reg
k59_96804_3	1173027.Mic7113_1032	9.52e-39	140.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,1G160@1117|Cyanobacteria,1HF5Z@1150|Oscillatoriales	1117|Cyanobacteria	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
k59_225744_1	400682.PAC_15716611	1.5e-214	611.0	COG0056@1|root,KOG1353@2759|Eukaryota,38ERH@33154|Opisthokonta,3BCEE@33208|Metazoa	33208|Metazoa	C	proton-transporting ATP synthase activity, rotational mechanism	ATP5A1	GO:0000275,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0006091,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0010876,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0019866,GO:0019915,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0022900,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0033036,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044769,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0050790,GO:0051179,GO:0051234,GO:0051235,GO:0051338,GO:0055085,GO:0055086,GO:0055114,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600,GO:1902769	-	ko:K02132	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_618184_1	314285.KT71_10879	8.25e-63	212.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,1J5GZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	GM	Polysaccharide biosynthesis protein	wbpM	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_96805_1	1411123.JQNH01000001_gene2713	4.47e-86	273.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_684756_2	86416.Clopa_0901	8.53e-17	90.5	COG3409@1|root,COG4193@1|root,COG5492@1|root,COG3409@2|Bacteria,COG4193@2|Bacteria,COG5492@2|Bacteria,1UUY0@1239|Firmicutes,24C6K@186801|Clostridia,36FQZ@31979|Clostridiaceae	186801|Clostridia	M	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,SH3_3
k59_878804_1	204773.HEAR3342	4.12e-68	228.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2W94M@28216|Betaproteobacteria,47825@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
k59_878804_2	426114.THI_1629	5.89e-17	77.8	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,1KKBF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S binding domain	-	-	-	ko:K21308	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4
k59_1008982_1	999541.bgla_2g18290	2.79e-31	122.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1K242@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_193426_1	880072.Desac_0419	9.44e-78	254.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MQZP@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_586618_1	1265502.KB905956_gene162	6.12e-100	307.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,4ACB9@80864|Comamonadaceae	28216|Betaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_96812_1	1123073.KB899242_gene1461	2.96e-179	515.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1XA61@135614|Xanthomonadales	135614|Xanthomonadales	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2
k59_910273_1	1499967.BAYZ01000068_gene1935	1.98e-11	71.6	COG3266@1|root,COG3420@1|root,COG4733@1|root,COG3266@2|Bacteria,COG3420@2|Bacteria,COG4733@2|Bacteria,2NS5M@2323|unclassified Bacteria	2|Bacteria	P	Fibronectin type 3 domain	-	-	-	ko:K12685,ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02044	1.B.12.5.1,1.B.12.5.3,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CHB_HEX_C_1,CHU_C,DUF1573,DUF285,F5_F8_type_C,Laminin_G_3,Lectin_legB,fn3
k59_848141_1	330214.NIDE3077	2.13e-81	259.0	COG0556@1|root,COG0556@2|Bacteria,3J0FS@40117|Nitrospirae	40117|Nitrospirae	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_618197_1	580332.Slit_2953	6.45e-129	382.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,44VMC@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_388289_1	443598.AUFA01000002_gene2451	2.03e-36	133.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2TTDW@28211|Alphaproteobacteria,3JT60@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_453876_1	1469245.JFBG01000027_gene1477	2.08e-89	273.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the citrate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Citrate_synt
k59_978461_1	765912.Thimo_0685	2.02e-20	91.3	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1WWTY@135613|Chromatiales	135613|Chromatiales	FP	Belongs to the GppA Ppx family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_978461_2	94624.Bpet1958	4.4e-26	103.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,3T1SI@506|Alcaligenaceae	28216|Betaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_417872_1	1123229.AUBC01000004_gene3194	8.54e-15	80.1	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,3JQQ8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA2	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_453883_1	663932.KB902575_gene2881	9.85e-106	320.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2TRI7@28211|Alphaproteobacteria,2JPWT@204441|Rhodospirillales	204441|Rhodospirillales	S	A circularly permuted ATPgrasp	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_128796_1	1165096.ARWF01000001_gene1577	1.85e-26	104.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KKB3@206350|Nitrosomonadales	206350|Nitrosomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_128796_2	323848.Nmul_A0303	7.64e-22	90.9	COG3312@1|root,COG3312@2|Bacteria,1NQF1@1224|Proteobacteria,2W4BE@28216|Betaproteobacteria,373BY@32003|Nitrosomonadales	28216|Betaproteobacteria	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_717408_1	643473.KB235930_gene1689	5.46e-24	100.0	COG0667@1|root,COG0667@2|Bacteria,1G1XV@1117|Cyanobacteria,1HM9D@1161|Nostocales	1117|Cyanobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_684780_2	1331660.L313_2807	1.31e-19	89.4	28RDB@1|root,2ZDSP@2|Bacteria,1RBF9@1224|Proteobacteria,1RQ0W@1236|Gammaproteobacteria,3NMWA@468|Moraxellaceae	1236|Gammaproteobacteria	S	Tail tubular protein	-	-	-	-	-	-	-	-	-	-	-	-	Tube
k59_161305_1	945713.IALB_1997	2.64e-86	263.0	COG4152@1|root,COG4152@2|Bacteria	2|Bacteria	S	ATPase activity	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_777140_1	397945.Aave_0200	1.27e-27	111.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4AAJP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_650494_1	477228.YO5_15780	2.46e-148	435.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,1Z1HK@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	Sulfite reductase, beta subunit (Hemoprotein)	cysI	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_62642_1	709797.CSIRO_0007	1.07e-101	309.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria,3K48V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_193455_1	864073.HFRIS_001789	1.24e-42	153.0	COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2VI1S@28216|Betaproteobacteria,473ZC@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_225787_1	1298867.AUES01000007_gene5083	1.48e-73	234.0	COG0165@1|root,COG0165@2|Bacteria,1MX0X@1224|Proteobacteria,2U2F3@28211|Alphaproteobacteria,3JW1S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Argininosuccinate lyase C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	ASL_C2,Lyase_1
k59_482690_1	402881.Plav_0817	4.52e-68	228.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,1JNCY@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_96842_1	1211115.ALIQ01000212_gene3292	5.21e-47	165.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TT24@28211|Alphaproteobacteria,3NA3X@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	dacA3	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Peptidase_S11
k59_717427_1	357808.RoseRS_1016	6.65e-13	74.3	COG1520@1|root,COG1520@2|Bacteria,2GBKY@200795|Chloroflexi,375ZC@32061|Chloroflexia	32061|Chloroflexia	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
k59_848182_1	640081.Dsui_2925	1.54e-73	238.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,2KV9F@206389|Rhodocyclales	206389|Rhodocyclales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_254572_2	994573.T472_0206650	3.71e-09	58.2	COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia,36MCG@31979|Clostridiaceae	186801|Clostridia	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_453909_1	243365.CV_2032	2.88e-109	326.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,2KPH1@206351|Neisseriales	206351|Neisseriales	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_650516_1	177437.HRM2_05280	1.58e-21	94.4	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42PKM@68525|delta/epsilon subdivisions,2WJCP@28221|Deltaproteobacteria,2MPWH@213118|Desulfobacterales	28221|Deltaproteobacteria	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_650516_2	1158614.I592_00830	5.93e-18	84.0	COG1806@1|root,COG1806@2|Bacteria,1TPG0@1239|Firmicutes,4HB0Q@91061|Bacilli,4B04D@81852|Enterococcaceae	91061|Bacilli	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_96855_1	504832.OCAR_7523	2.71e-64	213.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_978507_2	1499967.BAYZ01000119_gene3214	1.53e-97	295.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
k59_417922_1	1232410.KI421418_gene2194	2.88e-28	113.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,43S6Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	DnaJ_C,Rhomboid
k59_779964_1	1131553.JIBI01000007_gene1176	0.000554	41.2	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,2VITY@28216|Betaproteobacteria,372XK@32003|Nitrosomonadales	28216|Betaproteobacteria	U	MotA TolQ ExbB proton channel	exbB2	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_779964_2	1163617.SCD_n01894	5.47e-51	166.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Biopolymer transport protein	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_779964_3	1454004.AW11_03870	1.47e-49	169.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,1KQPJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_541351_1	637730.C8XUF7_9CAUD	4.67e-08	54.3	4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses  no RNA stage,4QPII@28883|Caudovirales,4QI76@10662|Myoviridae	10662|Myoviridae	S	DNA helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_541351_3	445696.E3ST05_9CAUD	1.3e-79	248.0	4QASV@10239|Viruses,4QWD9@35237|dsDNA viruses  no RNA stage,4QQ4N@28883|Caudovirales,4QIBN@10662|Myoviridae	10662|Myoviridae	S	recA bacterial DNA recombination protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_913380_1	765911.Thivi_3659	1.22e-151	442.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_1012061_2	717785.HYPMC_0557	2.52e-59	200.0	COG0802@1|root,COG3178@1|root,COG0802@2|Bacteria,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,3N772@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	MA20_24090	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH,TsaE
k59_1012062_1	1123257.AUFV01000007_gene316	1.41e-61	203.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1X48W@135614|Xanthomonadales	135614|Xanthomonadales	E	Acetylornithine deacetylase	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_420756_1	1385511.N783_11315	1.2e-06	52.8	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,2Y9M8@289201|Pontibacillus	91061|Bacilli	E	ABC transporter substrate-binding protein	dppA_1	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_420756_2	985665.HPL003_26490	1.9e-12	68.2	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBED@91061|Bacilli,26RTC@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_913394_1	864073.HFRIS_022308	7.34e-227	636.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,472HD@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_913405_2	640081.Dsui_2996	2.4e-53	184.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_913409_1	305700.B447_05268	1.19e-72	240.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales	206389|Rhodocyclales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_257377_1	460265.Mnod_3729	2.97e-13	68.2	COG1349@1|root,COG1349@2|Bacteria,1MUJG@1224|Proteobacteria,2TR8U@28211|Alphaproteobacteria,1JZ5T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Helix-turn-helix type 11 domain protein	glpR	-	-	ko:K02444	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
k59_257377_2	864069.MicloDRAFT_00044760	7.22e-18	83.6	COG1653@1|root,COG1653@2|Bacteria,1MV8A@1224|Proteobacteria,2TTPV@28211|Alphaproteobacteria,1JXPK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	COG1653 ABC-type sugar transport system, periplasmic component	MA20_44770	-	-	ko:K17321	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	SBP_bac_1,SBP_bac_8
k59_325345_1	879212.DespoDRAFT_03646	8.52e-14	72.8	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42N8J@68525|delta/epsilon subdivisions,2WK63@28221|Deltaproteobacteria,2MHTT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_485433_1	365046.Rta_06760	7.77e-43	152.0	COG3181@1|root,COG3181@2|Bacteria,1N7C4@1224|Proteobacteria,2VHNI@28216|Betaproteobacteria,4A9W4@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_780023_1	497321.C664_09680	1.76e-97	301.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,2KV5X@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_541417_1	1304874.JAFY01000002_gene687	4.62e-69	224.0	COG1593@1|root,COG1593@2|Bacteria,3TAK6@508458|Synergistetes	508458|Synergistetes	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_541421_1	880072.Desac_1962	6.63e-23	103.0	COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,43CF9@68525|delta/epsilon subdivisions,2X7QB@28221|Deltaproteobacteria,2MS55@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K16087,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.2,1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_1028893_1	1144325.PMI22_00274	3.2e-104	319.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_796054_1	323848.Nmul_A0484	1.3e-20	89.4	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,372QW@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_796054_2	323848.Nmul_A0485	3.6e-234	655.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,372TX@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_485453_1	985665.HPL003_21760	1.62e-85	261.0	COG3836@1|root,COG3836@2|Bacteria,1UZZG@1239|Firmicutes,4HEP6@91061|Bacilli,26X7G@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_545727_1	76114.p2A120	4.1e-81	256.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_798325_1	247633.GP2143_16186	4.11e-24	100.0	COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,1RZ89@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	belongs to the bacterial solute-binding protein 3 family	fliY	-	-	ko:K02030,ko:K02424,ko:K10036	ko02010,map02010	M00227,M00234,M00236	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3,3.A.1.3.10,3.A.1.3.14,3.A.1.3.2	-	-	SBP_bac_3
k59_489708_1	1266925.JHVX01000012_gene1678	2.54e-82	255.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,371YB@32003|Nitrosomonadales	28216|Betaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_798335_1	580332.Slit_2556	1.64e-41	151.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,2W04K@28216|Betaproteobacteria	28216|Betaproteobacteria	C	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_798335_2	472759.Nhal_0780	1.35e-14	72.8	COG0636@1|root,COG0636@2|Bacteria,1REA9@1224|Proteobacteria,1S51I@1236|Gammaproteobacteria,1WY7C@135613|Chromatiales	135613|Chromatiales	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_798358_1	926569.ANT_17330	4.38e-90	292.0	COG0366@1|root,COG0366@2|Bacteria,2G7SV@200795|Chloroflexi	200795|Chloroflexi	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k59_798360_1	1229909.NSED_00950	9.33e-53	167.0	COG1358@1|root,arCOG01751@2157|Archaea,41SMS@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
k59_798360_2	436308.Nmar_0224	1.2e-49	170.0	COG1109@1|root,arCOG00767@2157|Archaea,41S74@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1031305_1	439235.Dalk_4801	6.81e-46	160.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_1031314_1	991905.SL003B_4174	1.33e-31	115.0	COG0071@1|root,COG0071@2|Bacteria,1R9Y1@1224|Proteobacteria,2UA1J@28211|Alphaproteobacteria,4BS71@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Hsp20/alpha crystallin family	hspH	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
k59_545850_1	159087.Daro_1719	1.46e-10	61.2	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,2KU9B@206389|Rhodocyclales	206389|Rhodocyclales	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_545850_2	323848.Nmul_A2340	1.93e-117	339.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,371RU@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_545850_3	1198452.Jab_2c05890	7.44e-40	142.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,4729D@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_1031315_1	391037.Sare_0183	1.28e-38	141.0	COG1266@1|root,COG1266@2|Bacteria,2IGUR@201174|Actinobacteria,4DK0K@85008|Micromonosporales	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_286457_1	640081.Dsui_1023	2.03e-57	184.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2VINI@28216|Betaproteobacteria,2KVKB@206389|Rhodocyclales	206389|Rhodocyclales	D	cell division	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_286457_2	546274.EIKCOROL_01919	1.25e-11	63.9	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2VHK7@28216|Betaproteobacteria,2KQ8C@206351|Neisseriales	206351|Neisseriales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_286460_1	1121918.ARWE01000001_gene385	6.06e-86	267.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WTRK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k59_286470_1	243160.BMAA0975	4.55e-08	60.1	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHXW@28216|Betaproteobacteria,1KFCK@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM extracellular solute-binding protein, family 5	gsiB_6	-	-	ko:K02035,ko:K13889	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	SBP_bac_5
k59_798459_1	177437.HRM2_10540	6.35e-54	178.0	COG1102@1|root,COG1102@2|Bacteria,1R9XZ@1224|Proteobacteria,42R78@68525|delta/epsilon subdivisions,2WN7X@28221|Deltaproteobacteria,2MJR4@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
k59_286487_1	1366050.N234_27765	2.06e-102	321.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2VJZW@28216|Betaproteobacteria,1K3Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
k59_1031353_1	1232410.KI421413_gene678	5.9e-71	227.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,43U89@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	amino acid-binding ACT domain protein	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_545915_1	1254432.SCE1572_13360	7.21e-39	145.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	HemolysinCabind,Lactonase
k59_545925_1	436308.Nmar_0341	1.06e-86	266.0	COG1104@1|root,arCOG00066@2157|Archaea,41SB1@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_798543_1	1459636.NTE_02269	5.61e-24	96.3	COG0431@1|root,arCOG04624@2157|Archaea	2157|Archaea	S	NAD(P)H-dependent FMN reductase	ssuE1	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
k59_798553_1	491915.Aflv_1242	1.77e-68	221.0	COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,4H9M7@91061|Bacilli,21WC6@150247|Anoxybacillus	91061|Bacilli	E	Aminotransferase class-III	-	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_286565_1	935567.JAES01000025_gene1243	3.85e-29	116.0	COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1X3NQ@135614|Xanthomonadales	135614|Xanthomonadales	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_286565_2	1484157.PSNIH2_18380	1.01e-18	84.3	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,3VY7X@53335|Pantoea	1236|Gammaproteobacteria	S	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
k59_798561_1	1235279.C772_02815	3.34e-05	47.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4HAFP@91061|Bacilli,26DUQ@186818|Planococcaceae	91061|Bacilli	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_798579_1	1123371.ATXH01000005_gene2066	6.13e-105	323.0	COG0443@1|root,COG0443@2|Bacteria,2GGVT@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_546006_1	330214.NIDE0987	4.16e-68	212.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,3J0T7@40117|Nitrospirae	40117|Nitrospirae	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
k59_546006_2	330214.NIDE0986	3.88e-69	215.0	COG0107@1|root,COG0107@2|Bacteria,3J0GV@40117|Nitrospirae	40117|Nitrospirae	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_286614_1	1265505.ATUG01000003_gene606	8.46e-70	231.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria,2MJBB@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM DAHP synthetase I	-	-	2.5.1.54,5.4.99.5	ko:K03856,ko:K04516	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,DAHP_synth_1,PDT
k59_286662_1	693977.Deipr_1262	2.5e-60	197.0	COG0602@1|root,COG0602@2|Bacteria,1WKI7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_1031485_1	795666.MW7_3003	5.77e-72	232.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKMJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_286676_1	1370125.AUWT01000005_gene3158	7.1e-61	201.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,237Q8@1762|Mycobacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_546088_1	864051.BurJ1DRAFT_0792	2.92e-14	78.2	COG3303@1|root,COG3303@2|Bacteria,1R8WP@1224|Proteobacteria,2VZZU@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_798677_1	583345.Mmol_1356	1.29e-47	164.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,2KM0D@206350|Nitrosomonadales	206350|Nitrosomonadales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_1031501_1	864051.BurJ1DRAFT_3064	1.18e-45	151.0	COG2010@1|root,COG2010@2|Bacteria,1RG8M@1224|Proteobacteria,2VS50@28216|Betaproteobacteria,1KKX0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_1031501_2	1458357.BG58_39280	1.08e-31	120.0	COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,2VNAR@28216|Betaproteobacteria,1K2YQ@119060|Burkholderiaceae	28216|Betaproteobacteria	ET	SMART extracellular solute-binding protein, family 3	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,SBP_bac_3
k59_798725_2	335543.Sfum_3227	2.52e-28	108.0	COG4244@1|root,COG4892@1|root,COG4244@2|Bacteria,COG4892@2|Bacteria,1N3DP@1224|Proteobacteria,42U1X@68525|delta/epsilon subdivisions,2WQFI@28221|Deltaproteobacteria,2MRX2@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Cytochrome b5-like Heme/Steroid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cyt-b5
k59_798744_1	1163617.SCD_n00856	3.84e-140	413.0	COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,2VJ0K@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the peptidase M17 family	-	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
k59_1031541_1	10665.SEGB_BPT4	1.95e-29	115.0	4QAKE@10239|Viruses,4QUP7@35237|dsDNA viruses  no RNA stage,4QPCE@28883|Caudovirales,4QI56@10662|Myoviridae	10662|Myoviridae	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_546190_1	1131553.JIBI01000002_gene1782	4.66e-76	253.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,372K8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_546301_1	640081.Dsui_0408	1.57e-55	195.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,2KUT5@206389|Rhodocyclales	206389|Rhodocyclales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18303	-	M00642	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.17	-	-	ACR_tran
k59_798888_1	29581.BW37_05139	1.68e-11	63.2	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,2VHF0@28216|Betaproteobacteria,472VT@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_798888_3	1195246.AGRI_09120	1.35e-39	140.0	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,1RP9Y@1236|Gammaproteobacteria,46B5U@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0861 Membrane protein TerC, possibly involved in tellurium resistance	alx	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_1031648_1	987059.RBXJA2T_04503	1.93e-76	259.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1KJJ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_546316_1	999141.GME_12544	2.81e-96	308.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1XHKH@135619|Oceanospirillales	135619|Oceanospirillales	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_810938_1	264198.Reut_B3798	2.62e-25	107.0	COG3181@1|root,COG3181@2|Bacteria,1R81N@1224|Proteobacteria,2VMV6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_810938_2	1120983.KB894577_gene3578	1.91e-30	117.0	COG0673@1|root,COG0673@2|Bacteria,1PGFP@1224|Proteobacteria,2V8DN@28211|Alphaproteobacteria,1JQA3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1041028_1	395019.Bmul_0411	1.32e-67	220.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,1K1FK@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_1041028_2	640081.Dsui_0900	3.7e-17	79.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,2KVN6@206389|Rhodocyclales	206389|Rhodocyclales	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_1041076_1	1535422.ND16A_1065	8.17e-48	171.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,2Q60H@267889|Colwelliaceae	1236|Gammaproteobacteria	OU	Peptidase family S49	sppA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_1041096_1	696369.KI912183_gene1136	1.68e-27	109.0	COG1150@1|root,COG1150@2|Bacteria,1V6M0@1239|Firmicutes,24M4D@186801|Clostridia,26709@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
k59_1041141_1	1219031.BBJR01000041_gene2952	1.36e-27	112.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VK73@28216|Betaproteobacteria,4AB3Z@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_811185_1	580332.Slit_1269	1.61e-62	204.0	COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,PEGA
k59_811185_2	1485544.JQKP01000004_gene473	1.07e-18	84.7	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,44VP7@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_811193_1	374847.Kcr_0114	5.17e-18	88.2	COG1250@1|root,arCOG00249@2157|Archaea	2157|Archaea	I	Belongs to the enoyl-CoA hydratase isomerase family	-	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0043956	1.1.1.157,1.1.1.35,4.2.1.116,4.2.1.17,5.3.3.18	ko:K00074,ko:K15016,ko:K15019,ko:K15866	ko00360,ko00362,ko00650,ko00720,ko01100,ko01120,ko01200,map00360,map00362,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R01975,R01976,R03026,R03045,R05576,R06941,R09837,R09839	RC00004,RC00029,RC00117,RC00326,RC00831,RC00834,RC02689,RC03003	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1041215_1	1131266.ARWQ01000002_gene512	1.34e-79	255.0	COG0644@1|root,COG2440@1|root,arCOG00570@2157|Archaea,arCOG01984@2157|Archaea,41SXJ@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_1041237_1	330214.NIDE4238	1.01e-85	273.0	COG0495@1|root,COG0495@2|Bacteria,3J0F8@40117|Nitrospirae	40117|Nitrospirae	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
k59_1041254_1	279714.FuraDRAFT_2163	8.27e-45	159.0	COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2VISJ@28216|Betaproteobacteria,2KRXE@206351|Neisseriales	206351|Neisseriales	CH	FAD binding domain	-	-	1.14.13.24	ko:K22270	ko00362,ko01120,map00362,map01120	-	R02589	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
k59_1041281_1	1134474.O59_000249	1.13e-08	56.2	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1FFZF@10|Cellvibrio	1236|Gammaproteobacteria	S	LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1041281_2	640511.BC1002_0024	6.94e-38	140.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,1K1PV@119060|Burkholderiaceae	28216|Betaproteobacteria	LU	DNA protecting protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_811313_1	1173027.Mic7113_3013	1.26e-39	142.0	COG0113@1|root,COG0113@2|Bacteria,1G0YH@1117|Cyanobacteria,1H7CK@1150|Oscillatoriales	1117|Cyanobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_811313_2	419947.MRA_0531	4.14e-29	115.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,2333M@1762|Mycobacteriaceae	201174|Actinobacteria	H	Aminotransferase	hemL	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1041289_1	1304885.AUEY01000085_gene2476	4.33e-97	293.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,42NPH@68525|delta/epsilon subdivisions,2WIXM@28221|Deltaproteobacteria,2MPSE@213118|Desulfobacterales	28221|Deltaproteobacteria	M	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
k59_811325_1	713586.KB900536_gene1509	1.39e-105	319.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,1RPB3@1236|Gammaproteobacteria,1WWDM@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
k59_1041305_1	1454004.AW11_01210	5.33e-76	252.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,1KPQD@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_811347_1	330214.NIDE3752	3.78e-63	204.0	COG0530@1|root,COG0530@2|Bacteria	2|Bacteria	P	calcium, potassium:sodium antiporter activity	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_686677_2	709797.CSIRO_1871	1.29e-31	120.0	COG0559@1|root,COG0559@2|Bacteria,1R65S@1224|Proteobacteria,2VF60@28211|Alphaproteobacteria,3JW7X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_980422_1	653733.Selin_1858	4.79e-56	197.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria	2|Bacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_164265_1	330214.NIDE1081	3.23e-79	244.0	COG1196@1|root,COG1555@1|root,COG1196@2|Bacteria,COG1555@2|Bacteria	2|Bacteria	L	photosystem II stabilization	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
k59_783985_1	1415778.JQMM01000001_gene1297	1.07e-31	113.0	COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,1S6BB@1236|Gammaproteobacteria,1J68T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_783985_2	402881.Plav_2967	1.69e-20	92.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,1JP3A@119043|Rhodobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	nuoN2	-	1.6.5.3	ko:K00343,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_294849_1	648885.KB316282_gene1308	8.21e-74	233.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,1JR5D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM aminotransferase class V	MA20_43180	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_98988_1	1121405.dsmv_1320	3.89e-90	290.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_523447_1	1207063.P24_14234	1.13e-88	268.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TSF3@28211|Alphaproteobacteria,2JV0Q@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_458034_1	596152.DesU5LDRAFT_3643	9.04e-08	52.8	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42NGE@68525|delta/epsilon subdivisions,2WT0N@28221|Deltaproteobacteria,2M9YF@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Sodium sulphate symporter	-	-	-	ko:K03319,ko:K11106	-	-	-	-	ko00000,ko02000	2.A.47,2.A.47.3.3	-	-	Na_sulph_symp
k59_458034_2	479434.Sthe_0870	1.12e-91	291.0	COG0471@1|root,COG0471@2|Bacteria,2G7F4@200795|Chloroflexi	200795|Chloroflexi	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_980432_1	1121898.Q766_07920	3.34e-63	199.0	COG3145@1|root,COG3145@2|Bacteria,4NFEG@976|Bacteroidetes,1HWRD@117743|Flavobacteriia,2NSMD@237|Flavobacterium	976|Bacteroidetes	L	2OG-Fe(II) oxygenase	alkB	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
k59_849827_2	330214.NIDE0428	5.13e-54	169.0	COG0776@1|root,COG0776@2|Bacteria,3J19J@40117|Nitrospirae	40117|Nitrospirae	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_849827_3	330214.NIDE0427	4.36e-138	397.0	COG0616@1|root,COG0616@2|Bacteria,3J0J0@40117|Nitrospirae	40117|Nitrospirae	OU	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_360067_2	1123367.C666_16130	4.6e-76	234.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2VQ1Y@28216|Betaproteobacteria,2KW5V@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_556184_1	1142394.PSMK_29320	3.83e-106	329.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria	2|Bacteria	IQ	Class II Aldolase and Adducin N-terminal domain	rhaD	-	1.1.1.1,4.1.2.19	ko:K00001,ko:K01629	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R01785,R02124,R02263,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00438,RC00599,RC00603,RC00604,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Aldolase_II,adh_short_C2
k59_1040_1	1382359.JIAL01000001_gene1021	3.92e-53	185.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_392760_1	1123376.AUIU01000014_gene728	2.81e-44	152.0	COG0501@1|root,COG0501@2|Bacteria,3J0QG@40117|Nitrospirae	40117|Nitrospirae	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_262283_1	765914.ThisiDRAFT_0269	3.62e-91	272.0	COG1394@1|root,COG1394@2|Bacteria,1PA1A@1224|Proteobacteria,1S17V@1236|Gammaproteobacteria,1WWE8@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_262283_2	580332.Slit_2551	1.37e-05	47.0	COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria	1224|Proteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab
k59_686707_1	96561.Dole_2081	5.78e-62	193.0	COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,2MJGN@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM CMP dCMP deaminase zinc-binding	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
k59_686707_2	1116369.KB890027_gene4940	0.000773	42.7	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,43NC8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Serine hydroxymethyltransferase	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_490886_1	443143.GM18_0422	1.25e-29	123.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_947856_1	330214.NIDE3313	4.18e-135	421.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
k59_99015_1	314287.GB2207_10848	3.57e-08	54.3	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1J5B1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_882403_1	1173025.GEI7407_0491	6.96e-29	110.0	COG1397@1|root,COG1397@2|Bacteria,1G3YE@1117|Cyanobacteria,1H9NC@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
k59_131669_1	1485544.JQKP01000002_gene1562	1.05e-123	371.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,44VJY@713636|Nitrosomonadales	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_229521_1	1163617.SCD_n00573	3.54e-47	169.0	COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMT1@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type II and III secretion system protein	exeD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N_2
k59_556214_1	1123368.AUIS01000007_gene2765	1.65e-58	207.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1SMM0@1236|Gammaproteobacteria,2NBR8@225057|Acidithiobacillales	225057|Acidithiobacillales	P	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_392781_1	1097668.BYI23_B008110	7.24e-16	73.6	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1K4S6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_523488_1	1229909.NSED_01560	5.32e-100	307.0	COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota	651137|Thaumarchaeota	M	TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_490913_1	1415779.JOMH01000001_gene369	1.44e-69	214.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1X56E@135614|Xanthomonadales	135614|Xanthomonadales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_490914_1	745310.G432_10805	3.77e-52	181.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2K1RR@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_947878_1	269797.Mbar_A1661	2.74e-94	291.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1075_1	1357423.S5MV60_9CAUD	2.9e-05	53.1	4QBUC@10239|Viruses,4QVRG@35237|dsDNA viruses  no RNA stage,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_360105_1	1340493.JNIF01000003_gene4837	3.48e-14	73.2	COG0540@1|root,COG0540@2|Bacteria,3Y3KK@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_360105_2	1163408.UU9_01799	2.85e-16	75.5	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1X6P1@135614|Xanthomonadales	135614|Xanthomonadales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_131700_1	1380391.JIAS01000015_gene369	2.09e-36	140.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JREU@204441|Rhodospirillales	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_556241_1	1131813.AQVT01000001_gene3286	1.57e-13	70.9	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,1JS96@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	histidine kinase HAMP region domain protein	envZ	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_556241_2	1267005.KB911256_gene1497	4.6e-109	320.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,3N7ZT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1012610_1	1366050.N234_34825	1.03e-85	270.0	COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,2VJBZ@28216|Betaproteobacteria,1KB5K@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_425463_1	522772.Dacet_1977	3.56e-13	75.9	COG0760@1|root,COG0760@2|Bacteria,2GEX1@200930|Deferribacteres	200930|Deferribacteres	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_3
k59_458098_1	406818.XBJ1_2580	1e-93	293.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_197054_2	272568.GDI3621	0.000975	45.8	COG4117@1|root,COG4117@2|Bacteria,1MX97@1224|Proteobacteria,2U0ZF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_66455_1	1235813.JCM10003_2117	1.99e-08	55.8	COG2197@1|root,COG2197@2|Bacteria,4NMTW@976|Bacteroidetes,2G2UJ@200643|Bacteroidia,4AW5S@815|Bacteroidaceae	976|Bacteroidetes	K	Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_66455_2	1042326.AZNV01000030_gene3590	1.6e-05	47.4	COG4566@1|root,COG4566@2|Bacteria,1RAWG@1224|Proteobacteria,2U5XA@28211|Alphaproteobacteria,4BD0R@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_882443_1	1090318.ATTI01000001_gene2312	3.5e-06	48.5	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria,2K04P@204457|Sphingomonadales	204457|Sphingomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_882443_2	395493.BegalDRAFT_1965	3e-57	190.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,46067@72273|Thiotrichales	72273|Thiotrichales	M	lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_197055_1	582744.Msip34_2773	8.94e-57	197.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2VK7T@28216|Betaproteobacteria,2KMIC@206350|Nitrosomonadales	206350|Nitrosomonadales	IQ	PFAM AMP-dependent synthetase and ligase	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase
k59_751838_1	338969.Rfer_3938	2.45e-104	324.0	COG2203@1|root,COG2804@1|root,COG2203@2|Bacteria,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,4ACRA@80864|Comamonadaceae	28216|Betaproteobacteria	NU	General secretory system II, protein E domain protein	-	-	-	ko:K02454,ko:K02652,ko:K12276	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GAF,T2SSE,T2SSE_N
k59_392812_1	105559.Nwat_3050	6.14e-152	454.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales	135613|Chromatiales	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_490952_1	330214.NIDE1303	7.07e-98	315.0	COG0085@1|root,COG0085@2|Bacteria,3J0CW@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_686777_1	933262.AXAM01000003_gene2794	9.57e-75	233.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria,2MI91@213118|Desulfobacterales	28221|Deltaproteobacteria	I	TIGRFAM malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_197063_1	883.DvMF_0337	7.23e-36	132.0	COG0204@1|root,COG0204@2|Bacteria,1PY44@1224|Proteobacteria,42NR4@68525|delta/epsilon subdivisions,2WKKQ@28221|Deltaproteobacteria,2MAGC@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_817444_1	887327.HMPREF0476_1370	1.01e-127	376.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KQHP@206351|Neisseriales	206351|Neisseriales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_686780_1	743299.Acife_2633	9.42e-32	120.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RQS1@1236|Gammaproteobacteria,2NCAJ@225057|Acidithiobacillales	225057|Acidithiobacillales	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_686780_2	547144.HydHO_0590	1.68e-29	106.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_980512_2	1173020.Cha6605_1673	6.67e-35	129.0	COG1234@1|root,COG1234@2|Bacteria,1G1SW@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
k59_817447_1	1123072.AUDH01000009_gene463	5.44e-43	154.0	COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,2VFQZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_817447_2	1097668.BYI23_C012260	4.06e-60	195.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2W1F0@28216|Betaproteobacteria,1K8H0@119060|Burkholderiaceae	28216|Betaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_294938_1	768706.Desor_1290	6.96e-34	134.0	COG0247@1|root,COG2181@1|root,COG4656@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,COG4656@2|Bacteria,1TPG1@1239|Firmicutes,24BBE@186801|Clostridia,260K6@186807|Peptococcaceae	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Nitrate_red_gam
k59_882458_1	1265505.ATUG01000002_gene1874	1.34e-69	224.0	COG4191@1|root,COG4191@2|Bacteria,1R6WR@1224|Proteobacteria,42PFK@68525|delta/epsilon subdivisions,2WJSP@28221|Deltaproteobacteria,2MHRP@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_947919_1	1288494.EBAPG3_13350	2.31e-17	80.9	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria,372K1@32003|Nitrosomonadales	28216|Betaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_947919_2	977880.RALTA_A2260	3.91e-123	357.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHZW@28216|Betaproteobacteria,1K11F@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_654195_1	768671.ThimaDRAFT_0867	1.38e-76	239.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1S0WJ@1236|Gammaproteobacteria,1WWFB@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
k59_719358_1	762376.AXYL_04697	8.22e-69	226.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2W09W@28216|Betaproteobacteria,3T6CP@506|Alcaligenaceae	28216|Betaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_915360_1	1459636.NTE_00085	1.61e-100	306.0	COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B
k59_66496_1	945713.IALB_1869	9.2e-48	169.0	COG1009@1|root,COG1009@2|Bacteria	2|Bacteria	CP	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_425502_1	452637.Oter_1817	1.35e-116	348.0	COG3534@1|root,COG3534@2|Bacteria,46TJZ@74201|Verrucomicrobia,3K9HJ@414999|Opitutae	414999|Opitutae	G	alpha-L-arabinofuranosidase domain protein	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_784019_1	1301098.PKB_3007	1.18e-28	118.0	COG3203@1|root,COG3203@2|Bacteria,1RBTH@1224|Proteobacteria,1S3AI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_458137_1	76114.ebA4177	8.67e-78	247.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,2KVHH@206389|Rhodocyclales	206389|Rhodocyclales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_425507_1	1487953.JMKF01000091_gene5322	7.12e-23	99.8	COG3591@1|root,COG3591@2|Bacteria,1G8I7@1117|Cyanobacteria,1HDMZ@1150|Oscillatoriales	1117|Cyanobacteria	E	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin,Trypsin_2
k59_947948_1	1051632.TPY_2451	5.37e-15	79.7	COG0438@1|root,COG0438@2|Bacteria,1TSNT@1239|Firmicutes,248MH@186801|Clostridia	186801|Clostridia	M	Group 1 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
k59_849936_1	562742.F4YXT9_9CAUD	3.26e-73	236.0	4QG8X@10239|Viruses,4QVDN@35237|dsDNA viruses  no RNA stage,4QSBT@28883|Caudovirales,4QM55@10699|Siphoviridae	10699|Siphoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_327698_1	1347392.CCEZ01000074_gene1885	1.71e-46	165.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,36DY8@31979|Clostridiaceae	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.5	ko:K20447	ko00760,ko01120,map00760,map01120	-	R01720	RC00589	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_197106_1	1163617.SCD_n01950	1.64e-103	338.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_981611_2	1346791.M529_11985	8.4e-12	67.0	COG4381@1|root,COG4381@2|Bacteria,1N954@1224|Proteobacteria,2UH3T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG4381 Mu-like prophage protein gp46	-	-	-	-	-	-	-	-	-	-	-	-	GP46
k59_981611_4	1089439.KB902270_gene2574	1.8e-30	126.0	COG4379@1|root,COG4379@2|Bacteria,1MX68@1224|Proteobacteria	1224|Proteobacteria	S	Tail protein	gpP	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
k59_688244_1	1231190.NA8A_07854	6.43e-13	68.9	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,43IIE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_524851_1	316274.Haur_2798	6.96e-22	100.0	COG5002@1|root,COG5002@2|Bacteria,2G68T@200795|Chloroflexi,375B4@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_165737_1	1121406.JAEX01000016_gene1856	3.67e-73	233.0	COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,42NNW@68525|delta/epsilon subdivisions,2WMWA@28221|Deltaproteobacteria,2MA46@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	pfam abc	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
k59_459221_1	365044.Pnap_2180	7.75e-72	241.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_524853_1	1095769.CAHF01000015_gene2828	1.38e-68	214.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2VMN4@28216|Betaproteobacteria,47512@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	PFAM Class II Aldolase and Adducin N-terminal domain	fucA	-	4.1.1.104,4.1.2.17	ko:K01628,ko:K22130	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_655548_1	945713.IALB_1333	5.52e-42	142.0	COG4119@1|root,COG4119@2|Bacteria	2|Bacteria	L	NUDIX hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_263746_1	240302.BN982_02843	8.64e-12	66.2	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,3NDI9@45667|Halobacillus	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	fabG_4	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_263746_2	931276.Cspa_c22650	9.48e-23	90.5	COG3257@1|root,COG3257@2|Bacteria,1V6Z0@1239|Firmicutes,24K39@186801|Clostridia,36NXN@31979|Clostridiaceae	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_655549_2	436308.Nmar_0034	1.29e-10	61.2	COG2512@1|root,arCOG00374@2157|Archaea,41SUX@651137|Thaumarchaeota	651137|Thaumarchaeota	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_100430_1	1229909.NSED_09505	1.5e-86	262.0	COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Ribose-phosphate pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
k59_752875_2	1459636.NTE_00119	8.64e-58	183.0	COG2406@1|root,arCOG01093@2157|Archaea,41S6X@651137|Thaumarchaeota	2157|Archaea	S	Ferritin-like domain	dps	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_393969_1	314345.SPV1_13202	7.06e-16	76.6	COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria	1224|Proteobacteria	E	amino acid	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	AA_permease_2
k59_393969_2	192952.MM_3222	1.69e-37	130.0	arCOG04910@1|root,arCOG04910@2157|Archaea	2157|Archaea	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
k59_361397_1	1121116.KB894768_gene2032	9.53e-33	125.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2VHDR@28216|Betaproteobacteria,4AABI@80864|Comamonadaceae	28216|Betaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_361397_2	323261.Noc_0040	1.42e-12	67.4	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1WWMS@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_328921_1	1123296.JQKE01000012_gene186	1.12e-08	56.2	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,2KPX3@206351|Neisseriales	206351|Neisseriales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_328921_2	94624.Bpet2641	2.14e-104	309.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,3T1N5@506|Alcaligenaceae	28216|Betaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_165752_1	1211115.ALIQ01000040_gene3114	2.97e-24	103.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2TRK4@28211|Alphaproteobacteria,3NAQF@45404|Beijerinckiaceae	28211|Alphaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
k59_590188_1	948106.AWZT01000002_gene6279	5.54e-35	136.0	COG3210@1|root,COG3210@2|Bacteria,1R4T2@1224|Proteobacteria,2VKD7@28216|Betaproteobacteria,1K48S@119060|Burkholderiaceae	28216|Betaproteobacteria	U	TIGRFAM filamentous haemagglutinin family outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Haemagg_act
k59_296175_2	1041139.KB902724_gene4151	1.91e-101	300.0	COG0625@1|root,COG0625@2|Bacteria,1RK1K@1224|Proteobacteria,2V5U1@28211|Alphaproteobacteria,4BGB5@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_N
k59_296175_3	472759.Nhal_0303	6.75e-69	211.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,1S1HV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_851158_1	187272.Mlg_2624	2.69e-30	123.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_818881_1	296591.Bpro_1661	9.57e-127	372.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,2VNBZ@28216|Betaproteobacteria,4AD8C@80864|Comamonadaceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_393995_1	501479.ACNW01000087_gene3866	3.85e-25	108.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2TTC6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_752906_1	1042163.BRLA_c023150	1.05e-51	172.0	COG1082@1|root,COG1082@2|Bacteria,1TSIG@1239|Firmicutes,4IQQY@91061|Bacilli,26T29@186822|Paenibacillaceae	91061|Bacilli	G	Sugar phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_622839_1	472759.Nhal_3735	9.83e-44	152.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1WWJ2@135613|Chromatiales	135613|Chromatiales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_720793_1	580332.Slit_2506	5.14e-117	346.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,44V7E@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_198456_1	338969.Rfer_0214	6.03e-120	352.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2VIK5@28216|Betaproteobacteria,4ABK8@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_263802_1	1198452.Jab_2c03760	6.38e-54	179.0	COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,2VH67@28216|Betaproteobacteria,473K6@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	TatD related DNase	yjjV	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_35245_1	365046.Rta_21260	1.61e-38	142.0	COG0457@1|root,COG0457@2|Bacteria,1RAPH@1224|Proteobacteria,2VPDH@28216|Betaproteobacteria,4AJWC@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_35245_2	251221.35213551	2.04e-25	103.0	COG2370@1|root,COG2370@2|Bacteria,1G65K@1117|Cyanobacteria	1117|Cyanobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_230807_1	388413.ALPR1_02210	1.38e-87	290.0	COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47U6P@768503|Cytophagia	976|Bacteroidetes	T	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SnoaL_3
k59_361446_1	1163617.SCD_n00201	1.48e-123	357.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Exodeoxyribonuclease III	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_361446_2	595537.Varpa_3735	2.08e-14	72.8	COG0695@1|root,COG0695@2|Bacteria,1N7X3@1224|Proteobacteria,2VVPB@28216|Betaproteobacteria,4ADKN@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,Glutaredoxin
k59_720810_1	279714.FuraDRAFT_0140	6.44e-14	70.1	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2VSJV@28216|Betaproteobacteria,2KRGX@206351|Neisseriales	206351|Neisseriales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_361454_1	1458275.AZ34_12075	5.8e-94	291.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,4AA63@80864|Comamonadaceae	28216|Betaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	DAO,ETF_QO,FAD_binding_2,NAD_binding_8
k59_720817_1	257310.BB4854	6.5e-69	221.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,3T2YB@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_720817_2	768671.ThimaDRAFT_1380	1.42e-07	52.4	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WX7G@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC2	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_328981_1	1223521.BBJX01000002_gene2863	1.4e-50	177.0	COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2VNFS@28216|Betaproteobacteria,4AH2R@80864|Comamonadaceae	28216|Betaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,Fer4_7,FlpD
k59_67986_1	1499967.BAYZ01000084_gene4002	3.62e-56	180.0	299ND@1|root,3323H@2|Bacteria	2|Bacteria	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
k59_557700_1	330214.NIDE0551	1.09e-62	213.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8
k59_492436_1	383372.Rcas_1366	3.21e-90	269.0	COG3383@1|root,COG3383@2|Bacteria,2G65A@200795|Chloroflexi,3769N@32061|Chloroflexia	32061|Chloroflexia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.6.5.3	ko:K05588	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,NADH-G_4Fe-4S_3
k59_524942_1	983917.RGE_28020	4.51e-66	213.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,1KJDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_524942_2	290397.Adeh_1408	2.21e-14	73.9	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,42SR8@68525|delta/epsilon subdivisions,2WPN0@28221|Deltaproteobacteria,2YYWZ@29|Myxococcales	28221|Deltaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	-	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
k59_524945_1	1121935.AQXX01000081_gene1099	5.14e-16	79.7	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria,1XNPF@135619|Oceanospirillales	135619|Oceanospirillales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_524945_2	1286106.MPL1_03453	1.67e-31	117.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,46210@72273|Thiotrichales	72273|Thiotrichales	S	CcmB protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_165835_1	933262.AXAM01000058_gene3197	3.27e-121	358.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MIKK@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_165835_2	644282.Deba_0692	1.36e-16	79.0	COG2070@1|root,COG2070@2|Bacteria,1QZ4T@1224|Proteobacteria,43CFR@68525|delta/epsilon subdivisions,2X7QT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k59_263828_1	926569.ANT_31250	1.06e-77	257.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_2487_1	402777.KB235898_gene5585	8.26e-26	107.0	COG4715@1|root,COG4715@2|Bacteria,1G37G@1117|Cyanobacteria,1HAEP@1150|Oscillatoriales	1117|Cyanobacteria	S	Zinc finger, SWIM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
k59_67997_1	1122963.AUHB01000003_gene3872	6.13e-26	103.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2TTFE@28211|Alphaproteobacteria,36XEN@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF815)	MA20_41470	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
k59_67997_2	1123059.KB823011_gene1444	4.43e-29	108.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,43Y5D@69657|Hyphomonadaceae	28211|Alphaproteobacteria	U	COG1862 Preprotein translocase subunit YajC	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_198502_1	582899.Hden_0692	4.45e-81	253.0	arCOG05916@1|root,30GTU@2|Bacteria,1RDX8@1224|Proteobacteria,2U853@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_198502_2	1417296.U879_08090	4.4e-95	281.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,2U3QM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_9
k59_949277_1	1120999.JONM01000002_gene951	2.75e-75	233.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	cmk	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase,Cytidylate_kin
k59_818950_1	479434.Sthe_2691	1.22e-64	218.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_720858_1	484770.UFO1_4667	3.33e-42	146.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,4H3JN@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_720858_2	1121943.KB899997_gene1870	1.38e-14	73.6	COG4948@1|root,COG4948@2|Bacteria,1NAKW@1224|Proteobacteria,1RNE2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	gudD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008872,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0071704,GO:1901575	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	iECO26_1355.ECO26_3857	MR_MLE_C,MR_MLE_N
k59_165855_1	420324.KI912061_gene6192	3.1e-64	209.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,1JYYS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
k59_784431_1	1288494.EBAPG3_8250	5.39e-112	337.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2VHY5@28216|Betaproteobacteria,372U2@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_752975_1	452637.Oter_0831	1.27e-35	136.0	COG2366@1|root,COG2366@2|Bacteria	2|Bacteria	D	antibiotic biosynthetic process	acyII	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_752975_2	1121930.AQXG01000001_gene1272	7.86e-12	67.4	COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1IQN0@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_165857_1	189753.AXAS01000062_gene8434	1.38e-37	144.0	COG1289@1|root,COG1289@2|Bacteria,1Q5JG@1224|Proteobacteria,2VBX6@28211|Alphaproteobacteria,3K2KA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Aromatic acid exporter family member 1	-	-	-	-	-	-	-	-	-	-	-	-	FUSC
k59_459333_1	765912.Thimo_2227	3.3e-42	146.0	COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,1RMZN@1236|Gammaproteobacteria,1WWIN@135613|Chromatiales	135613|Chromatiales	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_883764_1	153948.NAL212_1478	6.74e-54	187.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,372ME@32003|Nitrosomonadales	28216|Betaproteobacteria	I	AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_752978_1	748247.AZKH_0496	3.02e-18	82.0	COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,2KWVJ@206389|Rhodocyclales	206389|Rhodocyclales	D	cell division protein	ftsN	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_752978_2	1288494.EBAPG3_27750	1.9e-23	96.7	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,372F6@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA,Thioredoxin_4
k59_688384_1	1247649.D560_1184	1.38e-14	72.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,3T207@506|Alcaligenaceae	28216|Betaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_688384_2	666681.M301_0210	3.28e-43	145.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria,2KMM5@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_394069_1	1247963.JPHU01000016_gene1070	9.74e-27	108.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,2TSI5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_362509_1	1265505.ATUG01000002_gene2074	2.89e-75	246.0	COG1109@1|root,COG1109@2|Bacteria,1QUGD@1224|Proteobacteria,43BUU@68525|delta/epsilon subdivisions,2WKYP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_689383_1	1000565.METUNv1_01903	5.15e-102	319.0	COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	2.7.13.3	ko:K20975	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
k59_199477_1	945713.IALB_1522	3.55e-88	266.0	COG1861@1|root,COG1861@2|Bacteria	2|Bacteria	M	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase	-	-	5.4.3.8	ko:K01845,ko:K07257	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,CTP_transf_3
k59_329980_1	1300345.LF41_2765	2.01e-73	247.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales	135614|Xanthomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_362510_1	1123261.AXDW01000001_gene1372	1.2e-43	152.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1RQUV@1236|Gammaproteobacteria,1X4AA@135614|Xanthomonadales	135614|Xanthomonadales	T	phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_362510_2	1110697.NCAST_32_03660	1.03e-35	139.0	COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria,4FWPS@85025|Nocardiaceae	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_623926_1	196367.JNFG01000011_gene6041	5.2e-16	73.9	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_3589_1	1149133.ppKF707_6196	1.87e-21	95.9	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	ko:K11914,ko:K12266	ko05132,map05132	-	-	-	ko00000,ko00001,ko02044,ko03000	-	-	-	HTH_8,Sigma54_activat,V4R,XylR_N
k59_3589_2	1121405.dsmv_0797	6.69e-18	79.3	COG0484@1|root,COG0484@2|Bacteria,1RHHJ@1224|Proteobacteria,42SMN@68525|delta/epsilon subdivisions,2WPJN@28221|Deltaproteobacteria,2MNCE@213118|Desulfobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
k59_1013544_1	1454004.AW11_02009	2.54e-116	356.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_3597_1	273075.Ta0810	3.35e-07	57.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota	28890|Euryarchaeota	C	aldehyde ferredoxin oxidoreductase	aor-2	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_656743_1	1163617.SCD_n00627	3.88e-29	106.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria	28216|Betaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_656743_2	93220.LV28_12920	1.4e-40	142.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,1K0IX@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_950346_1	28258.KP05_16445	6.67e-138	403.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1XH5I@135619|Oceanospirillales	135619|Oceanospirillales	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k59_950352_1	1144319.PMI16_04966	2.08e-22	94.7	COG3655@1|root,COG3655@2|Bacteria,1RBPK@1224|Proteobacteria,2VIYU@28216|Betaproteobacteria,474EB@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26,HTH_3
k59_820044_1	1392838.AWNM01000001_gene1718	3.73e-93	281.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,2W0I7@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_36312_1	1408164.MOLA814_02456	1.86e-99	295.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2VSFQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Dehydrogenase	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_852245_1	1158318.ATXC01000001_gene335	8.88e-81	251.0	COG0216@1|root,COG0216@2|Bacteria,2G3PA@200783|Aquificae	200783|Aquificae	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_820045_1	1307761.L21SP2_2698	5.09e-06	55.5	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,HisKA_3,Hpt,Reg_prop,Response_reg,Y_Y_Y
k59_166898_1	1234364.AMSF01000090_gene2456	7.33e-49	172.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_656758_1	383372.Rcas_2675	7.06e-10	64.7	COG2304@1|root,COG4412@1|root,COG2304@2|Bacteria,COG4412@2|Bacteria,2GB3W@200795|Chloroflexi,377V9@32061|Chloroflexia	32061|Chloroflexia	E	PFAM von Willebrand factor type A	-	-	3.4.21.50	ko:K01337	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	VWA
k59_36320_1	765911.Thivi_0061	2.34e-65	218.0	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_917959_1	977880.RALTA_A1035	3.6e-108	312.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2VIWK@28216|Betaproteobacteria,1K10B@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_3626_1	999541.bgla_1g05650	1.44e-86	277.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1K2P6@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Malic enzyme	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
k59_558811_1	102107.XP_008220472.1	3.7e-75	250.0	COG1003@1|root,KOG2040@2759|Eukaryota,37JTX@33090|Viridiplantae,3GEI5@35493|Streptophyta,4JMMM@91835|fabids	35493|Streptophyta	E	The glycine cleavage system catalyzes the degradation of glycine	-	GO:0000166,GO:0001505,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009536,GO:0009570,GO:0009579,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0016054,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046686,GO:0048046,GO:0050896,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_394979_1	1279019.ARQK01000050_gene1293	9.76e-37	131.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales	135613|Chromatiales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_264872_1	713586.KB900536_gene2104	4.49e-30	110.0	COG2920@1|root,COG2920@2|Bacteria,1N6BZ@1224|Proteobacteria,1S8YA@1236|Gammaproteobacteria,1WYWH@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM sulfur relay protein, TusE DsrC DsvC family	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_264872_2	177437.HRM2_03910	1.46e-19	82.0	COG2261@1|root,COG2261@2|Bacteria,1NGEB@1224|Proteobacteria,42VUV@68525|delta/epsilon subdivisions,2WS8X@28221|Deltaproteobacteria,2MNUA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_264872_3	1123487.KB892836_gene3234	5.2e-181	534.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VJK5@28216|Betaproteobacteria,2KY51@206389|Rhodocyclales	206389|Rhodocyclales	G	pyruvate phosphate dikinase	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_525947_1	926569.ANT_03290	1.95e-104	317.0	COG0119@1|root,COG0119@2|Bacteria,2G5V9@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_362551_2	84531.JMTZ01000020_gene3711	2.49e-19	84.0	COG2839@1|root,COG2839@2|Bacteria,1MZEV@1224|Proteobacteria,1SAFY@1236|Gammaproteobacteria,1X6YB@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
k59_297227_1	1173020.Cha6605_6346	3.68e-61	207.0	COG2132@1|root,COG2132@2|Bacteria,1G2BC@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_591330_1	706587.Desti_0143	1.72e-07	58.2	COG2202@1|root,COG4191@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,MASE3,PAS,PAS_3,PAS_4,PAS_9,dCache_1
k59_1013558_1	335543.Sfum_2961	8.95e-35	132.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42NI6@68525|delta/epsilon subdivisions,2WKI1@28221|Deltaproteobacteria,2MQBT@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_656774_2	237368.SCABRO_00477	6.22e-18	88.2	COG1198@1|root,COG1198@2|Bacteria,2IY1F@203682|Planctomycetes	203682|Planctomycetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_101596_1	768706.Desor_3023	1.7e-51	182.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,247UH@186801|Clostridia,26417@186807|Peptococcaceae	186801|Clostridia	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_784726_1	1267535.KB906767_gene3736	1.58e-85	274.0	COG0438@1|root,COG0438@2|Bacteria,3Y68X@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_950382_1	1521187.JPIM01000154_gene926	5.84e-57	205.0	COG0642@1|root,COG0784@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,2GBI2@200795|Chloroflexi,376CQ@32061|Chloroflexia	32061|Chloroflexia	T	ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
k59_558831_1	1031711.RSPO_c00536	1.55e-84	263.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,1K273@119060|Burkholderiaceae	28216|Betaproteobacteria	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_330029_1	981369.JQMJ01000001_gene6656	1.39e-68	227.0	COG1609@1|root,COG1609@2|Bacteria,2GK7G@201174|Actinobacteria,2NKXB@228398|Streptacidiphilus	201174|Actinobacteria	K	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,HTH_Tnp_4
k59_753947_1	1499967.BAYZ01000099_gene4393	9.12e-103	311.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	BT1,MFS_1
k59_231784_1	1121004.ATVC01000002_gene546	7.71e-67	214.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,2KPMT@206351|Neisseriales	206351|Neisseriales	T	His Kinase A (phosphoacceptor) domain	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_623982_1	1116472.MGMO_96c00130	5.29e-64	221.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEV2@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_689439_1	330214.NIDE1933	9.13e-127	369.0	COG2116@1|root,COG2116@2|Bacteria	2|Bacteria	P	formate transmembrane transporter activity	focA	-	-	ko:K02598,ko:K06212,ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.2,1.A.16.3	-	-	Form_Nir_trans
k59_689439_2	330214.NIDE3182	1.54e-130	382.0	COG0205@1|root,COG0205@2|Bacteria,3J0Y1@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_297244_1	857087.Metme_4504	1.46e-29	108.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1XF6N@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_297244_2	95619.PM1_0229085	5.49e-72	229.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658	ATP-synt_ab,ATP-synt_ab_N
k59_721966_1	886293.Sinac_7015	7.41e-05	50.8	COG2230@1|root,COG2230@2|Bacteria,2J0X9@203682|Planctomycetes	203682|Planctomycetes	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.103	ko:K05929	ko00564,map00564	-	R02037,R06868,R06869	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko01000	-	-	-	-
k59_753949_1	1144319.PMI16_04454	7.54e-22	93.6	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,47311@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
k59_753949_2	323848.Nmul_A0564	5.31e-36	134.0	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,371X2@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_427904_1	519989.ECTPHS_12913	1.41e-82	253.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales	135613|Chromatiales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_784727_2	1000565.METUNv1_01871	8.94e-46	149.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,2KWPQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_101609_1	32057.KB217478_gene7494	1.91e-21	102.0	COG2319@1|root,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HINJ@1161|Nostocales	1117|Cyanobacteria	L	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,WD40
k59_525955_1	1267535.KB906767_gene1972	1.27e-54	179.0	COG1484@1|root,COG1484@2|Bacteria,3Y4QK@57723|Acidobacteria,2JNWI@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
k59_623996_1	391735.Veis_4279	1.15e-66	217.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJBE@28216|Betaproteobacteria,4ACD2@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_36366_2	582744.Msip34_1407	5.79e-21	89.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,2KKTC@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_264917_1	113395.AXAI01000002_gene5515	1.6e-58	195.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_199559_1	1123367.C666_00120	2.69e-28	115.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,2KUFR@206389|Rhodocyclales	206389|Rhodocyclales	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
k59_656808_1	933262.AXAM01000027_gene2082	3.98e-65	207.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	SMART Chromosomal replication initiator DnaA domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
k59_134378_1	1163617.SCD_n01665	4.1e-48	162.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria	28216|Betaproteobacteria	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_134378_2	983917.RGE_24120	1.51e-23	100.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,1KKET@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_591386_1	765952.PUV_26840	1.06e-74	244.0	COG5433@1|root,COG5433@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4,DDE_Tnp_1_assoc
k59_427941_1	1265313.HRUBRA_01494	4.69e-52	175.0	COG1597@1|root,COG1597@2|Bacteria,1RB97@1224|Proteobacteria,1S4B3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Mmp37
k59_460298_1	765912.Thimo_2264	1.39e-38	145.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_656840_1	945713.IALB_0329	5.86e-79	245.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	1.3.1.101,1.3.1.111,1.3.1.83,1.3.7.11	ko:K10960,ko:K17830	ko00564,ko00860,ko00900,ko01100,ko01110,map00564,map00860,map00900,map01100,map01110	-	R02063,R08754,R08755,R08756,R10325,R10326,R10331,R11226,R11518	RC00212,RC00522,RC01823,RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
k59_362637_1	748247.AZKH_3249	3.67e-06	53.1	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,2KU79@206389|Rhodocyclales	206389|Rhodocyclales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_558905_2	1229172.JQFA01000004_gene752	5.84e-05	50.1	COG2267@1|root,COG2267@2|Bacteria,1GPX4@1117|Cyanobacteria,1HHZW@1150|Oscillatoriales	1117|Cyanobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_395045_1	1123024.AUII01000012_gene4218	5.28e-32	119.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DZ0W@85010|Pseudonocardiales	201174|Actinobacteria	E	Branched-chain amino acid transport	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_395045_2	1460634.JCM19037_1275	0.000622	42.7	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_820149_1	991905.SL003B_2049	4.17e-20	88.6	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria,4BPBT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_297309_1	469383.Cwoe_5298	1.23e-41	155.0	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4CQ78@84995|Rubrobacteria	84995|Rubrobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_199611_1	887898.HMPREF0551_1150	8.14e-50	172.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VM1X@28216|Betaproteobacteria,1K2H7@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	General secretion pathway protein F	gspF	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_950466_1	1157708.KB907452_gene3890	6.4e-16	79.7	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM Phospholipase D Transphosphatidylase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_264972_1	1269813.ATUL01000026_gene2628	6.02e-06	47.4	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria	1224|Proteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,Sigma54_activat
k59_264972_2	526222.Desal_3050	6.05e-11	62.8	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,42MG4@68525|delta/epsilon subdivisions,2WN8P@28221|Deltaproteobacteria,2MA53@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_689536_1	391038.Bphy_1468	9.2e-51	181.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1K1V8@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_820163_1	880073.Calab_2582	5.83e-69	220.0	COG2309@1|root,COG2309@2|Bacteria,2NPEI@2323|unclassified Bacteria	2|Bacteria	E	Thermophilic metalloprotease (M29)	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
k59_821304_1	1266925.JHVX01000008_gene325	2.31e-67	216.0	COG0421@1|root,COG0421@2|Bacteria,1RBWW@1224|Proteobacteria,2VK7S@28216|Betaproteobacteria,372CE@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Spermine/spermidine synthase domain	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_494905_1	388051.AUFE01000024_gene4680	2.29e-22	95.5	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,1K372@119060|Burkholderiaceae	28216|Betaproteobacteria	M	shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_494905_2	640081.Dsui_0890	2.32e-38	136.0	COG2891@1|root,COG2891@2|Bacteria,1RBNF@1224|Proteobacteria,2VQQ3@28216|Betaproteobacteria,2KW9X@206389|Rhodocyclales	206389|Rhodocyclales	M	shape-determining protein	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
k59_494905_3	1100720.ALKN01000028_gene2550	1.08e-82	266.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,4AAEW@80864|Comamonadaceae	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_429058_1	1242864.D187_004712	1.07e-67	221.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_984006_1	330214.NIDE2475	8.13e-99	315.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	rocA	-	1.2.1.88,1.5.5.2	ko:K00294,ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512,iYO844.BSU37780	Aldedh,Pro_dh
k59_690707_1	71139.XP_010046011.1	5.54e-18	82.4	KOG4853@1|root,KOG4853@2759|Eukaryota,37UN2@33090|Viridiplantae,3GY4V@35493|Streptophyta	35493|Streptophyta	S	mitotic sister chromatid biorientation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_168198_1	765912.Thimo_1062	3.01e-49	174.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_331334_1	1502851.FG93_04345	6.42e-78	242.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,2TVRD@28211|Alphaproteobacteria,3K5Z9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
k59_494909_1	945713.IALB_0483	2.79e-74	227.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_885904_1	1288298.rosmuc_03651	6.55e-50	169.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,46P3Y@74030|Roseovarius	28211|Alphaproteobacteria	C	COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs	xdhB	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_951658_1	395965.Msil_1760	3.36e-36	138.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,3NAVM@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_625200_1	987059.RBXJA2T_17047	4.43e-190	545.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VKSM@28216|Betaproteobacteria,1KNEK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	frdA	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_526509_1	583355.Caka_2259	2.18e-24	108.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,46TY6@74201|Verrucomicrobia	74201|Verrucomicrobia	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_4965_1	497321.C664_07263	1.66e-37	135.0	COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,2VIVQ@28216|Betaproteobacteria,2KUCY@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_625212_1	1071679.BG57_12750	1.35e-120	352.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1JZPR@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_363812_1	997346.HMPREF9374_3906	1.4e-28	118.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4HC4B@91061|Bacilli	91061|Bacilli	S	C4-dicarboxylate ABC transporter	siaT_4	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_885926_1	1268622.AVS7_02916	4.78e-42	142.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,4AAIY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_885926_2	1562701.BBOF01000052_gene1524	4.77e-110	330.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,1K08M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_1014166_1	330214.NIDE0049	7.13e-14	70.5	COG1028@1|root,COG1028@2|Bacteria,3J0J6@40117|Nitrospirae	330214.NIDE0049|-	IQ	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
k59_1014166_2	329726.AM1_2606	2.34e-33	126.0	COG2519@1|root,COG2519@2|Bacteria,1GQT1@1117|Cyanobacteria	1117|Cyanobacteria	J	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_723272_1	879212.DespoDRAFT_02970	2.19e-91	293.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_200764_1	128390.XP_009464918.1	6.08e-05	50.8	KOG3607@1|root,KOG3607@2759|Eukaryota,38B6W@33154|Opisthokonta,3B9I0@33208|Metazoa,3CU5P@33213|Bilateria,47ZWW@7711|Chordata,48V13@7742|Vertebrata,4GS43@8782|Aves	33208|Metazoa	O	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	GO:0003674,GO:0003824,GO:0005575,GO:0006508,GO:0006509,GO:0006807,GO:0007155,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0019538,GO:0022610,GO:0031224,GO:0033619,GO:0043170,GO:0044238,GO:0044425,GO:0045026,GO:0061024,GO:0061025,GO:0070011,GO:0071704,GO:0071840,GO:0098609,GO:0140096,GO:1901564	-	ko:K06835,ko:K08610,ko:K16068	-	-	-	-	ko00000,ko01000,ko01002,ko04516	-	-	-	ADAM_CR,Disintegrin,EGF_2,Pep_M12B_propep,Reprolysin
k59_494947_1	882378.RBRH_02336	2.59e-46	159.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,1K1BD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM cytochrome c, class I	cyc	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_266132_1	1286171.EAL2_c09600	4.6e-51	178.0	COG0436@1|root,COG0436@2|Bacteria,1TQP8@1239|Firmicutes,24BFE@186801|Clostridia	186801|Clostridia	E	Aminotransferase	aspD	-	4.1.1.12	ko:K09758	ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230	-	R00397,R00863	RC00282,RC00399,RC00400	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_658145_2	1288494.EBAPG3_5130	9.53e-113	341.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,372TA@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	lpdA	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_853535_1	864051.BurJ1DRAFT_1080	2.59e-28	112.0	COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2VI33@28216|Betaproteobacteria,1KJMC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_853535_2	85643.Tmz1t_3362	4.46e-29	112.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VHRM@28216|Betaproteobacteria,2KV48@206389|Rhodocyclales	206389|Rhodocyclales	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_625232_1	192952.MM_0871	7.38e-22	93.2	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,2N99Q@224756|Methanomicrobia	224756|Methanomicrobia	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
k59_625232_2	984262.SGRA_0242	2.53e-21	95.1	COG0006@1|root,COG0006@2|Bacteria,4NG40@976|Bacteroidetes,1IPMC@117747|Sphingobacteriia	976|Bacteroidetes	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_4995_1	317013.NY99_04025	1.48e-31	117.0	COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,1S13N@1236|Gammaproteobacteria,1X4XE@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the GST superfamily	gst5	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_3
k59_4995_2	743722.Sph21_3431	1.76e-15	77.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,4NEQX@976|Bacteroidetes,1IQ4K@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA polymerase III, epsilon subunit	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T
k59_232759_1	1121028.ARQE01000006_gene4501	1.64e-56	189.0	2DC0H@1|root,2ZC7P@2|Bacteria,1RB77@1224|Proteobacteria,2U8GK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_168250_1	1123367.C666_10950	5.07e-18	79.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2VQ39@28216|Betaproteobacteria,2KW7A@206389|Rhodocyclales	206389|Rhodocyclales	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
k59_168250_2	292415.Tbd_0748	1.95e-64	206.0	COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2VRJN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_658157_2	1112217.PPL19_16695	8.8e-62	203.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Aminotran_3
k59_951708_1	640081.Dsui_1386	6.5e-98	298.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2VHX9@28216|Betaproteobacteria,2KUEJ@206389|Rhodocyclales	206389|Rhodocyclales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
k59_266147_1	1266925.JHVX01000006_gene2248	1.71e-95	286.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,372T5@32003|Nitrosomonadales	28216|Betaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_592645_1	358681.BBR47_01030	1.21e-80	268.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,4H9NB@91061|Bacilli,26QY4@186822|Paenibacillaceae	91061|Bacilli	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_102950_2	1210884.HG799464_gene11262	5.63e-78	243.0	COG3335@1|root,COG3335@2|Bacteria,2J12Q@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_723298_1	330214.NIDE4049	3.85e-59	187.0	2BXN6@1|root,2ZK04@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_135681_1	330214.NIDE0971	2.5e-76	238.0	COG0674@1|root,COG0674@2|Bacteria,3J0WN@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_494973_1	1211777.BN77_1130	1.91e-18	84.3	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,4B99V@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldo keto reductase	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0055114	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_494973_2	1125973.JNLC01000014_gene2630	2.75e-14	75.1	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,3K3HD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	X-Pro dipeptidyl-peptidase (S15 family)	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_560173_1	292415.Tbd_2287	2.98e-68	214.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VQQJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_363851_1	2903.EOD36914	1.05e-18	90.1	28Z0Q@1|root,2R5UW@2759|Eukaryota	2759|Eukaryota	S	glucose transmembrane transporter activity	-	-	-	ko:K08175	-	-	-	-	ko00000,ko02000	2.A.1.7	-	-	MFS_1
k59_494979_1	1132509.C447_13197	4.85e-66	216.0	COG3119@1|root,arCOG02785@2157|Archaea,2XU7V@28890|Euryarchaeota,23T6D@183963|Halobacteria	183963|Halobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Sulfatase
k59_429131_1	420324.KI912087_gene7233	5.7e-36	137.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JSYN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16
k59_429131_2	319003.Bra1253DRAFT_01520	5.05e-05	45.4	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_8
k59_70479_1	323097.Nham_2785	3.43e-157	452.0	COG3328@1|root,COG3328@2|Bacteria,1R81T@1224|Proteobacteria,2TT28@28211|Alphaproteobacteria,3JVY8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG3328 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_396009_1	1288494.EBAPG3_18290	2.09e-168	476.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,371X1@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_200810_1	468556.AQYG01000046_gene1245	7.3e-80	260.0	COG1018@1|root,COG2124@1|root,COG1018@2|Bacteria,COG2124@2|Bacteria,2GJCV@201174|Actinobacteria,4GBNV@85026|Gordoniaceae	201174|Actinobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1,p450
k59_363859_1	926569.ANT_26050	1.28e-30	118.0	COG5433@1|root,COG5433@2|Bacteria,2G91M@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_135697_1	436308.Nmar_1701	2.65e-46	154.0	COG1468@1|root,arCOG00790@2157|Archaea,41T4T@651137|Thaumarchaeota	651137|Thaumarchaeota	V	CRISPR-associated protein Cas4	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
k59_429136_1	1123257.AUFV01000009_gene2287	3.21e-61	204.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,1RQ1W@1236|Gammaproteobacteria,1X4S0@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_658191_1	1157708.KB907453_gene4353	4.73e-36	130.0	COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,2VSDP@28216|Betaproteobacteria,4AED8@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM Blue (type 1) copper domain	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,CusF_Ec
k59_5034_1	436308.Nmar_1519	3.79e-73	223.0	COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota	651137|Thaumarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	-	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
k59_5034_2	436308.Nmar_1518	7.14e-08	51.2	arCOG04405@1|root,arCOG04405@2157|Archaea	2157|Archaea	S	ASCH domain	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
k59_429139_1	296591.Bpro_4324	2.62e-73	228.0	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2VM81@28216|Betaproteobacteria,4AGC0@80864|Comamonadaceae	28216|Betaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_298490_1	1121403.AUCV01000040_gene4320	7.49e-80	246.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42M3H@68525|delta/epsilon subdivisions,2WJGE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_984094_1	323848.Nmul_A1777	8.56e-137	397.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,37299@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
k59_919353_1	68199.JNZO01000002_gene1323	4.16e-08	59.3	COG0701@1|root,COG0701@2|Bacteria,2HZBT@201174|Actinobacteria	201174|Actinobacteria	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
k59_821405_1	330214.NIDE4348	1.12e-121	350.0	COG0066@1|root,COG0066@2|Bacteria,3J10U@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_37693_1	1229909.NSED_09250	8.25e-61	192.0	arCOG08776@1|root,arCOG08776@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_135706_2	85643.Tmz1t_2956	3.91e-87	263.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,2KY5Y@206389|Rhodocyclales	206389|Rhodocyclales	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_331445_1	997346.HMPREF9374_3069	4.39e-44	157.0	COG0026@1|root,COG0026@2|Bacteria,1TQCD@1239|Firmicutes,4H9M5@91061|Bacilli,27B6X@186824|Thermoactinomycetaceae	91061|Bacilli	F	ATP-grasp domain	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh_C,ATP-grasp
k59_821414_1	292415.Tbd_2281	9.32e-31	110.0	2BK43@1|root,32EHP@2|Bacteria,1RDAC@1224|Proteobacteria,2W3NZ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_821414_2	1158756.AQXQ01000012_gene1996	3.69e-87	259.0	COG1047@1|root,COG1047@2|Bacteria,1REQ1@1224|Proteobacteria,1S2MS@1236|Gammaproteobacteria,1WY6J@135613|Chromatiales	135613|Chromatiales	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	-
k59_754988_2	1123504.JQKD01000079_gene5790	7.01e-79	244.0	COG0329@1|root,COG0329@2|Bacteria,1MWMN@1224|Proteobacteria,2W0EN@28216|Betaproteobacteria	28216|Betaproteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
k59_298502_1	243090.RB7502	4.15e-11	71.2	COG2304@1|root,COG2304@2|Bacteria,2IXP0@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
k59_919365_1	323848.Nmul_A0385	1.78e-76	244.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,371NE@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pykA	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_984109_1	314278.NB231_00480	5.33e-104	325.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	hlyB	-	-	ko:K11004	ko02010,ko03070,ko05133,map02010,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_625291_1	472759.Nhal_2431	1.42e-119	369.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1X2PM@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_331461_1	314271.RB2654_09069	7.26e-32	121.0	COG1136@1|root,COG1136@2|Bacteria,1NHCD@1224|Proteobacteria	1224|Proteobacteria	V	(ABC) transporter	ycfV	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_496030_1	765910.MARPU_16480	9.87e-59	202.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales	135613|Chromatiales	U	type IV pilus secretin PilQ	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_952816_1	887062.HGR_12227	1.6e-10	62.4	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9V8@80864|Comamonadaceae	28216|Betaproteobacteria	T	response regulator	yfhA	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_6113_1	1111728.ATYS01000011_gene394	3.54e-91	279.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,1RQ9E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7,4.4.1.24	ko:K16846,ko:K16850	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
k59_822453_1	228410.NE0970	2.03e-80	254.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,3724I@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_822453_2	1000565.METUNv1_03798	4.18e-08	55.1	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,2KV63@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_201853_1	1437609.BCAL_0084	4.63e-28	102.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4D1FB@85004|Bifidobacteriales	201174|Actinobacteria	K	'Cold-shock' DNA-binding domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_201855_1	1123368.AUIS01000019_gene1219	7.79e-42	154.0	COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales	225057|Acidithiobacillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CZB,EAL,GGDEF,PAS,PAS_4
k59_201855_2	1187851.A33M_1630	5.88e-19	88.6	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,3FEER@34008|Rhodovulum	28211|Alphaproteobacteria	G	Glucokinase	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
k59_71599_2	95619.PM1_0204890	4.33e-77	242.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Lytic murein transglycosylase	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_267251_2	1101190.ARWB01000001_gene2301	8.02e-70	227.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,36Y0V@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Glutamine amidotransferase domain	asnO	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_561258_1	998674.ATTE01000001_gene1740	3.73e-28	111.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,46068@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_561258_2	580332.Slit_1883	6.77e-23	91.7	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,44W01@713636|Nitrosomonadales	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_561258_3	745014.OMB55_00007900	2.16e-29	112.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1J618@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iPC815.YPO3361,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300	IspD
k59_462067_1	1380394.JADL01000002_gene1159	3.41e-79	243.0	COG0559@1|root,COG0559@2|Bacteria,1MXGK@1224|Proteobacteria,2TVKT@28211|Alphaproteobacteria,2JVW1@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_854630_1	864069.MicloDRAFT_00005470	4.37e-114	337.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JT7T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_985138_1	1232437.KL662050_gene5331	1.5e-31	127.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1R9T9@1224|Proteobacteria,42PPQ@68525|delta/epsilon subdivisions,2WKI9@28221|Deltaproteobacteria,2MJ5A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
k59_71617_1	1500894.JQNN01000001_gene313	2.5e-38	134.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria,474DC@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Biopolymer transport protein	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_71617_2	765912.Thimo_3379	1.31e-05	47.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1WWWV@135613|Chromatiales	135613|Chromatiales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_6148_1	1150469.RSPPHO_01524	5.92e-48	169.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria,2JQAJ@204441|Rhodospirillales	204441|Rhodospirillales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_952855_1	314285.KT71_02627	1.25e-39	150.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_691892_1	1266925.JHVX01000006_gene2095	2.94e-41	137.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,373DE@32003|Nitrosomonadales	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_691892_2	1485544.JQKP01000011_gene760	1.28e-18	80.5	COG5416@1|root,COG5416@2|Bacteria,1N4UI@1224|Proteobacteria,2VU63@28216|Betaproteobacteria,44W2U@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Pfam:DUF1049	-	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	LapA_dom
k59_691892_3	85643.Tmz1t_3032	1.04e-117	350.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,2KU7Z@206389|Rhodocyclales	206389|Rhodocyclales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16
k59_1014664_1	1379270.AUXF01000003_gene3552	5.31e-24	107.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060,Kelch_1,Kelch_6,Malectin,NPCBM
k59_169363_1	883126.HMPREF9710_01217	4.95e-39	138.0	COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria,2VU54@28216|Betaproteobacteria,474IZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
k59_496081_2	1123392.AQWL01000001_gene1517	6.25e-26	99.0	COG2920@1|root,COG2920@2|Bacteria,1N6BU@1224|Proteobacteria,2WC7H@28216|Betaproteobacteria,1KT76@119069|Hydrogenophilales	119069|Hydrogenophilales	P	DsrC like protein	-	-	-	-	-	-	-	-	-	-	-	-	DsrC
k59_785492_1	522306.CAP2UW1_0622	4e-64	212.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KQCV@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_854647_1	1121405.dsmv_1716	8.73e-24	92.0	2EEQW@1|root,338IK@2|Bacteria,1NCXT@1224|Proteobacteria,42VG4@68525|delta/epsilon subdivisions,2WR9K@28221|Deltaproteobacteria,2MKU5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
k59_854647_2	1121405.dsmv_2792	3.25e-19	85.5	COG1102@1|root,COG1102@2|Bacteria,1N69V@1224|Proteobacteria,42UCK@68525|delta/epsilon subdivisions,2WQ7M@28221|Deltaproteobacteria,2MKKM@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
k59_201894_1	130081.XP_005706692.1	5.68e-26	108.0	COG0673@1|root,KOG2741@2759|Eukaryota	2759|Eukaryota	V	D-xylose 1-dehydrogenase (NADP+) activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_561289_1	1485544.JQKP01000003_gene118	2.96e-69	224.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,44VMC@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_920451_1	76114.ebA6818	8.27e-32	120.0	COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria,2KU8P@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA	ybbB	-	-	ko:K06917	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Rhodanese
k59_724420_2	1191523.MROS_0017	7.92e-57	187.0	COG0836@1|root,COG0836@2|Bacteria	2|Bacteria	M	mannose-1-phosphate guanylyltransferase activity	manC	-	2.7.7.13,5.3.1.8,5.4.2.8	ko:K00971,ko:K01840,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01818,R01819	RC00002,RC00376,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00940	MannoseP_isomer,NTP_transferase
k59_136782_1	1121035.AUCH01000016_gene2125	2.42e-77	246.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,2KU6N@206389|Rhodocyclales	206389|Rhodocyclales	C	cytochrome	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_561292_1	67352.JODS01000002_gene1296	2.01e-06	55.8	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria	201174|Actinobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_267290_2	1121127.JAFA01000041_gene4316	2.61e-40	144.0	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2WA57@28216|Betaproteobacteria,1K26A@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11
k59_332510_1	426114.THI_0135	1.51e-99	301.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,1KJRD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_593789_1	671143.DAMO_0586	1.02e-81	263.0	COG0046@1|root,COG0046@2|Bacteria,2NNPS@2323|unclassified Bacteria	2|Bacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_233693_1	1354722.JQLS01000008_gene2109	3.28e-34	126.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,46NSC@74030|Roseovarius	28211|Alphaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	MA20_18095	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_854669_1	1112217.PPL19_17344	2.25e-18	89.4	COG3280@1|root,COG3280@2|Bacteria	2|Bacteria	G	synthase	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_38774_1	1168065.DOK_15059	2.39e-76	238.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RS8E@1236|Gammaproteobacteria,1JABB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_1014675_1	177437.HRM2_23910	1.97e-119	353.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2WIWV@28221|Deltaproteobacteria,2MIVW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1825	AMP-binding,AMP-binding_C_2
k59_785500_2	1126627.BAWE01000004_gene2920	1e-21	89.4	COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2U7V5@28211|Alphaproteobacteria,3JZAP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_691929_1	1242864.D187_006569	5.66e-13	67.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,2YV0E@29|Myxococcales	28221|Deltaproteobacteria	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_430217_1	335543.Sfum_2906	2.46e-83	259.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2MR9B@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	transporter, DctM subunit	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_626319_1	159087.Daro_3260	3.11e-144	422.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,2KU6N@206389|Rhodocyclales	206389|Rhodocyclales	C	cytochrome	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_985184_1	1255043.TVNIR_1668	7.72e-84	267.0	COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria,1WWPV@135613|Chromatiales	135613|Chromatiales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,Cyc-maltodext_C,Cyc-maltodext_N
k59_299531_1	543728.Vapar_3045	5.83e-12	67.8	COG3391@1|root,COG3391@2|Bacteria,1MXJJ@1224|Proteobacteria,2VPSR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
k59_724453_1	457570.Nther_2383	2.04e-14	79.3	COG0438@1|root,COG0438@2|Bacteria,1UHSF@1239|Firmicutes,25EAY@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_626326_1	395494.Galf_0636	1.74e-23	103.0	COG2114@1|root,COG2982@1|root,COG3064@1|root,COG2114@2|Bacteria,COG2982@2|Bacteria,COG3064@2|Bacteria,1QZY2@1224|Proteobacteria,2VTEI@28216|Betaproteobacteria,44WBC@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_299533_1	880072.Desac_2842	2.64e-109	324.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,42MUE@68525|delta/epsilon subdivisions,2WJFZ@28221|Deltaproteobacteria,2MR9K@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
k59_332548_1	945713.IALB_0798	2.41e-23	95.9	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding
k59_887031_1	1121930.AQXG01000009_gene278	2.12e-31	126.0	COG0517@1|root,COG0517@2|Bacteria,4NGW0@976|Bacteroidetes,1IV0R@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GCS2
k59_6215_1	1304275.C41B8_00775	1.01e-61	204.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	JKL	DEAD-box RNA helicase involved in	rhlB	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,RhlB
k59_104092_3	445688.E3SNU2_9CAUD	1.11e-252	731.0	4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses  no RNA stage,4QPWY@28883|Caudovirales,4QHVQ@10662|Myoviridae	10662|Myoviridae	S	nucleotide binding	-	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019058,GO:0019079,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	-
k59_755902_1	977880.RALTA_B0210	5.93e-69	224.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6UF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_169431_1	644282.Deba_1045	5.47e-105	322.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_734784_1	1161401.ASJA01000001_gene295	5.95e-58	194.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,43WI7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	tetA	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
k59_308709_1	344747.PM8797T_13620	1.03e-55	184.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_1019858_2	1282876.BAOK01000001_gene1086	1.78e-11	66.2	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,4BQ7C@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_16450_2	1535422.ND16A_0840	1.94e-07	53.5	COG1595@1|root,COG1595@2|Bacteria,1QDHS@1224|Proteobacteria,1SS07@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_764022_1	402881.Plav_0586	7.3e-47	167.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Flavoprotein involved in K transport	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_3
k59_896454_1	314231.FP2506_08611	1.57e-57	183.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,2PJMY@255475|Aurantimonadaceae	28211|Alphaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_241799_1	1123392.AQWL01000003_gene126	1.41e-36	144.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,2VITK@28216|Betaproteobacteria,1KSGE@119069|Hydrogenophilales	119069|Hydrogenophilales	CE	Proline dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh,Pro_dh
k59_764026_1	1454004.AW11_03237	6.21e-78	243.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,1KQ8K@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	icd	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_16454_1	580332.Slit_2097	7.02e-102	311.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2VHX9@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.2	ko:K01769	ko00230,map00230	-	R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	Guanylate_cyc
k59_16454_2	228410.NE1893	2.11e-174	491.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,371PG@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_16454_3	748280.NH8B_1740	2.81e-20	83.2	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2VVV6@28216|Betaproteobacteria,2KRUV@206351|Neisseriales	206351|Neisseriales	S	Zinc-finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
k59_636203_1	999541.bgla_1g03820	5.43e-91	273.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,1K0MT@119060|Burkholderiaceae	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_669600_1	316274.Haur_4995	1.95e-35	137.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi,376CG@32061|Chloroflexia	32061|Chloroflexia	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_308727_1	580332.Slit_1856	7.6e-86	276.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,44V1M@713636|Nitrosomonadales	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	fadN	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_374567_1	1313172.YM304_07800	3.17e-85	263.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4CNC4@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Pfam:Zinicin_2	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
k59_994897_1	638303.Thal_1453	1.42e-08	59.7	COG0616@1|root,COG0616@2|Bacteria,2G409@200783|Aquificae	200783|Aquificae	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_963268_1	1357272.AVEO02000190_gene4328	0.000334	48.5	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,1Z9ZS@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
k59_930715_1	717606.PaecuDRAFT_0468	9.89e-35	139.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,26TP2@186822|Paenibacillaceae	91061|Bacilli	KLT	serine threonine protein kinase	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_146845_1	1121403.AUCV01000051_gene2126	4.28e-84	272.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2MIG4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_636224_2	1137799.GZ78_00180	2.18e-19	87.8	2EDW0@1|root,337R6@2|Bacteria,1N9FY@1224|Proteobacteria,1T68Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_48660_1	1229909.NSED_00170	4.67e-122	357.0	COG0677@1|root,arCOG00252@2157|Archaea,41S8F@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114166_1	436308.Nmar_1052	9.19e-55	173.0	arCOG08740@1|root,arCOG08740@2157|Archaea,41T52@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_896490_2	645512.GCWU000246_01480	0.000122	51.2	COG0653@1|root,COG0653@2|Bacteria,3TA76@508458|Synergistetes	508458|Synergistetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_342470_1	1449346.JQMO01000002_gene935	2.36e-47	171.0	COG0654@1|root,COG0654@2|Bacteria,2GKUZ@201174|Actinobacteria,2M2JI@2063|Kitasatospora	201174|Actinobacteria	CH	FAD binding domain	sppF	-	-	ko:K14672	-	-	-	-	ko00000,ko01008	-	-	-	FAD_binding_3
k59_81885_1	404589.Anae109_0591	1.18e-07	52.0	COG3714@1|root,COG3714@2|Bacteria,1PCNW@1224|Proteobacteria,435D5@68525|delta/epsilon subdivisions,2WZQQ@28221|Deltaproteobacteria,2Z2IZ@29|Myxococcales	28221|Deltaproteobacteria	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
k59_274509_1	748247.AZKH_p0006	2.18e-130	380.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,2KXTF@206389|Rhodocyclales	206389|Rhodocyclales	C	Oxidative deamination of D-amino acids	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
k59_734851_1	1454004.AW11_03085	5.83e-114	350.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_702465_1	608538.HTH_0935	1.74e-61	206.0	COG3581@1|root,COG3581@2|Bacteria,2G4PU@200783|Aquificae	200783|Aquificae	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_702467_1	1121405.dsmv_3708	3.86e-96	293.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2MI1E@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_833008_1	1120983.KB894574_gene1117	9.52e-47	170.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2TV7R@28211|Alphaproteobacteria,1JQ2B@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K16052,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3,1.A.23.4	-	-	MS_channel
k59_405101_1	1123368.AUIS01000009_gene2453	3.58e-87	264.0	COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,1T54P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
k59_1019898_1	1268635.Loa_00363	8.28e-12	65.5	COG0262@1|root,COG1995@1|root,COG0262@2|Bacteria,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1JCGN@118969|Legionellales	118969|Legionellales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_1019898_2	1121035.AUCH01000009_gene843	6.24e-64	203.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,2KUK6@206389|Rhodocyclales	206389|Rhodocyclales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_669665_1	1485544.JQKP01000015_gene2093	1.92e-73	230.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2VHCH@28216|Betaproteobacteria,44W6U@713636|Nitrosomonadales	28216|Betaproteobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_241850_1	1415778.JQMM01000001_gene1140	1.02e-131	412.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,1J55S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
k59_48706_1	1123261.AXDW01000001_gene1140	2.02e-86	265.0	COG0451@1|root,COG0451@2|Bacteria,1RGHF@1224|Proteobacteria,1RQTC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_930772_1	177437.HRM2_40670	5.47e-129	375.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2WJW9@28221|Deltaproteobacteria,2MIK9@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0899	F420_oxidored,P5CR_dimer
k59_603830_1	436308.Nmar_1513	1.3e-21	88.6	COG1325@1|root,arCOG01042@2157|Archaea,41SWK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	RNA binding	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
k59_603830_2	1229909.NSED_08325	2.15e-32	123.0	COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_470258_1	1266925.JHVX01000008_gene322	1.61e-209	605.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,3725I@32003|Nitrosomonadales	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadN	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_81921_2	323848.Nmul_A1856	2.71e-75	229.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2VJVJ@28216|Betaproteobacteria,372G5@32003|Nitrosomonadales	28216|Betaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
k59_374654_1	264732.Moth_2380	5.65e-93	286.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,42F4E@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_241874_1	497321.C664_14833	3.19e-155	457.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,2KV91@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_864522_2	1255043.TVNIR_0122	3.07e-18	82.8	COG3267@1|root,COG3267@2|Bacteria,1NWGN@1224|Proteobacteria,1S1RJ@1236|Gammaproteobacteria,1X05B@135613|Chromatiales	135613|Chromatiales	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_506311_1	305700.B447_07022	5.1e-100	305.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,2KVK4@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_669694_1	322710.Avin_01680	1.06e-50	163.0	COG0760@1|root,COG0760@2|Bacteria,1QUCX@1224|Proteobacteria,1S6X5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	PFAM NifZ	nifZ	-	-	ko:K02597	-	-	-	-	ko00000	-	-	-	NifZ
k59_669694_2	1056820.KB900674_gene2564	9.36e-31	110.0	2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,1S999@1236|Gammaproteobacteria,2PQG8@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Nitrogen fixation protein NifW	nifW	-	-	ko:K02595	-	-	-	-	ko00000	-	-	-	NifW
k59_470275_2	1121912.AUHD01000015_gene1133	6.08e-43	158.0	COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,1HXF9@117743|Flavobacteriia	976|Bacteroidetes	E	acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_506314_2	742159.HMPREF0004_3277	1.68e-48	165.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,3T25H@506|Alcaligenaceae	28216|Betaproteobacteria	K	Transcriptional regulator	cbl	-	-	ko:K13635	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_603857_2	94624.Bpet0662	8.69e-29	110.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,3T48Y@506|Alcaligenaceae	28216|Betaproteobacteria	S	Acyl-CoA thioesterase	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_603857_3	948106.AWZT01000011_gene1997	3.69e-10	60.1	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,1K2TQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_342544_1	1449351.RISW2_03740	1.06e-63	207.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,4KM3S@93682|Roseivivax	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
k59_833065_1	429009.Adeg_0447	2.71e-40	140.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,42GHZ@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM NUDIX hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_833065_2	1168034.FH5T_15225	4.41e-19	80.9	COG3324@1|root,COG3324@2|Bacteria,4NMFV@976|Bacteroidetes,2FTH2@200643|Bacteroidia	976|Bacteroidetes	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_764136_1	1485544.JQKP01000017_gene643	3.83e-99	314.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,44VD6@713636|Nitrosomonadales	28216|Betaproteobacteria	C	2-oxoglutarate dehydrogenase N-terminus	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_669701_1	640081.Dsui_3442	5.82e-126	369.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VKI2@28216|Betaproteobacteria,2KX65@206389|Rhodocyclales	206389|Rhodocyclales	S	FAD-dependent pyridine nucleotide-disulfide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_342545_1	1265502.KB905933_gene2022	3.59e-116	342.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,4AB2U@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_896570_1	296591.Bpro_3501	3.84e-64	204.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2VTVS@28216|Betaproteobacteria,4AFJA@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
k59_274538_1	1123393.KB891326_gene83	9.86e-230	650.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,1KSJ5@119069|Hydrogenophilales	119069|Hydrogenophilales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8
k59_669707_1	1262449.CP6013_2868	1.52e-27	107.0	COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24HZR@186801|Clostridia,36VG2@31979|Clostridiaceae	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_669707_2	1121396.KB893112_gene1986	5.27e-12	65.9	COG0467@1|root,COG1396@1|root,COG0467@2|Bacteria,COG1396@2|Bacteria,1PE60@1224|Proteobacteria,42NFD@68525|delta/epsilon subdivisions,2WK1C@28221|Deltaproteobacteria,2MIB3@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
k59_179471_1	652103.Rpdx1_1844	4.87e-27	114.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,2TUJQ@28211|Alphaproteobacteria,3JSDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	MA20_01900	-	-	-	-	-	-	-	-	-	-	-	-
k59_470291_1	1288298.rosmuc_00068	0.000701	47.8	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2TR02@28211|Alphaproteobacteria,46NB0@74030|Roseovarius	28211|Alphaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	MA20_04510	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_506328_1	1205680.CAKO01000027_gene4749	3.75e-57	191.0	COG0395@1|root,COG0395@2|Bacteria,1PG6Q@1224|Proteobacteria,2U1HZ@28211|Alphaproteobacteria,2JW7Y@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_506328_2	1038860.AXAP01000107_gene4557	7.12e-11	62.4	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TZRR@28211|Alphaproteobacteria,3JTDV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_765069_2	497321.C664_10128	8.67e-39	145.0	COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,2KUT7@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	yfhK	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_604893_1	375286.mma_2427	1.44e-45	163.0	28M5B@1|root,2ZAJ4@2|Bacteria,1R7Y9@1224|Proteobacteria,2VSMK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_736008_1	637389.Acaty_c2281	1.19e-59	202.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales	225057|Acidithiobacillales	P	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1020411_1	330214.NIDE0204	6.76e-103	307.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,3J13F@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_645289_2	375286.mma_2284	7.98e-30	110.0	COG1846@1|root,COG1846@2|Bacteria,1PWBQ@1224|Proteobacteria,2WBWN@28216|Betaproteobacteria,47899@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_744368_1	864051.BurJ1DRAFT_1410	4.39e-108	317.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,1KJPE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_351602_1	396588.Tgr7_0567	1.33e-96	301.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_1003868_1	448385.sce6983	5.83e-66	211.0	COG3209@1|root,COG3385@1|root,COG3209@2|Bacteria,COG3385@2|Bacteria,1R55Y@1224|Proteobacteria,437YG@68525|delta/epsilon subdivisions,2X38D@28221|Deltaproteobacteria,2YUTS@29|Myxococcales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_448737_2	266265.Bxe_B1671	1.21e-40	140.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria,1K1I0@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE8	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_351606_1	267608.RSc1421	2.94e-30	120.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,1K0K1@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_57443_1	94624.Bpet1901	4.45e-109	323.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,3T1C0@506|Alcaligenaceae	28216|Betaproteobacteria	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_842584_1	519989.ECTPHS_07501	6.93e-33	122.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales	135613|Chromatiales	H	Uroporphyrinogen III synthase	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_842584_2	740709.A10D4_11601	5.03e-09	57.4	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,2QF1G@267893|Idiomarinaceae	1236|Gammaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iPC815.YPO3849	Porphobil_deam,Porphobil_deamC
k59_612947_1	234267.Acid_4952	3.67e-17	84.7	COG0154@1|root,COG0154@2|Bacteria,3Y3E5@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_940174_1	1454004.AW11_03899	3.16e-15	73.9	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,1KQ5F@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766,ko:K15312	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	ECH_1
k59_940174_2	497321.C664_18072	1.85e-58	195.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,2KVX8@206389|Rhodocyclales	206389|Rhodocyclales	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_317097_1	1123368.AUIS01000003_gene1788	2.45e-137	399.0	COG0530@1|root,COG0530@2|Bacteria,1PW8G@1224|Proteobacteria	1224|Proteobacteria	P	COG0530 Ca2 Na antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_842599_1	765914.ThisiDRAFT_2036	6e-17	85.9	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_3
k59_536684_2	290397.Adeh_0881	2.71e-12	66.6	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WKYT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
k59_905188_1	1454004.AW11_02962	2.26e-56	185.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,1KPYC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_57468_1	279714.FuraDRAFT_2581	2.83e-25	107.0	COG3203@1|root,COG3203@2|Bacteria,1P7S0@1224|Proteobacteria,2VNY2@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
k59_711981_1	298653.Franean1_7131	6.59e-37	141.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4EUCV@85013|Frankiales	201174|Actinobacteria	T	integral membrane sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_351635_1	289376.THEYE_A1687	8.59e-92	283.0	COG0069@1|root,COG1149@1|root,COG0069@2|Bacteria,COG1149@2|Bacteria,3J0SV@40117|Nitrospirae	40117|Nitrospirae	C	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_940191_2	3988.XP_002540187.1	6.37e-06	47.8	COG0023@1|root,2R8U2@2759|Eukaryota,382MA@33090|Viridiplantae,3GRBP@35493|Streptophyta	35493|Streptophyta	J	Translation initiation factor SUI1	-	-	-	-	-	-	-	-	-	-	-	-	SUI1
k59_842605_1	330214.NIDE3313	6.19e-123	388.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
k59_249910_1	404380.Gbem_3523	9.77e-37	142.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,43AN8@68525|delta/epsilon subdivisions,2X62F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
k59_581058_1	1232437.KL662025_gene936	1.91e-121	356.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria,2MITS@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_279196_1	292415.Tbd_0234	6.93e-89	291.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,1KRGX@119069|Hydrogenophilales	119069|Hydrogenophilales	E	B12 binding domain	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_873596_1	1336235.JAEG01000001_gene2274	3.44e-19	87.0	COG0708@1|root,COG0708@2|Bacteria,1NHXD@1224|Proteobacteria	1224|Proteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_873596_2	1123057.P872_16505	5.03e-31	120.0	COG0405@1|root,COG0405@2|Bacteria,4NG3X@976|Bacteroidetes,47MKS@768503|Cytophagia	976|Bacteroidetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_317118_1	330214.NIDE4030	2.86e-38	144.0	COG5009@1|root,COG5009@2|Bacteria,3J0BH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding protein OB-like domain	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_91375_1	690585.JNNU01000056_gene462	1.31e-78	250.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria,4B700@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve
k59_91377_1	335543.Sfum_0450	4.28e-17	85.9	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,2MR7H@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_383274_1	237368.SCABRO_00954	1.9e-83	268.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_744425_1	1121952.ATXT01000015_gene32	7.9e-17	82.8	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4FTMW@85023|Microbacteriaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_645348_1	1417296.U879_06615	5.46e-72	230.0	COG0053@1|root,COG0053@2|Bacteria,1PXF4@1224|Proteobacteria,2TV0K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_842628_1	439235.Dalk_3901	1.24e-78	258.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MJ0S@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_57493_1	945713.IALB_0834	6.54e-75	236.0	COG0341@1|root,COG0341@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_873611_1	870187.Thini_3424	2.53e-23	94.4	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,460X4@72273|Thiotrichales	72273|Thiotrichales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_873611_2	305700.B447_11817	1.38e-27	106.0	COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,2VSA4@28216|Betaproteobacteria,2KWC8@206389|Rhodocyclales	206389|Rhodocyclales	S	peptidase S16	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
k59_581075_1	706587.Desti_3265	2.26e-58	198.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_57494_1	1255043.TVNIR_1648	1.34e-77	243.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1WWJ4@135613|Chromatiales	135613|Chromatiales	S	Radical SAM superfamily	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_188162_1	1403313.AXBR01000008_gene733	1.01e-35	139.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,4H9UP@91061|Bacilli,1ZBAT@1386|Bacillus	91061|Bacilli	L	Single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
k59_351671_1	309801.trd_0154	2.83e-06	49.7	COG2048@1|root,COG2048@2|Bacteria	2|Bacteria	C	Heterodisulfide reductase, subunit B	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_351671_2	309801.trd_0155	5.79e-95	281.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8
k59_123421_2	1380394.JADL01000002_gene1219	9.56e-66	213.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2JV0E@204441|Rhodospirillales	204441|Rhodospirillales	E	Methionine synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_873615_2	931627.MycrhDRAFT_3995	1.63e-21	91.7	COG1595@1|root,COG1595@2|Bacteria,2I9C1@201174|Actinobacteria,235YM@1762|Mycobacteriaceae	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_905225_1	102129.Lepto7375DRAFT_7579	4.74e-41	148.0	COG5433@1|root,COG5433@2|Bacteria,1G2IT@1117|Cyanobacteria,1HHU1@1150|Oscillatoriales	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_478195_1	1123504.JQKD01000013_gene1015	8.58e-31	117.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VJNG@28216|Betaproteobacteria,4ADN9@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_123426_1	269799.Gmet_0584	1.23e-26	114.0	COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_7,TPR_8
k59_536709_1	1121434.AULY01000007_gene1473	2.43e-101	307.0	COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,42MJX@68525|delta/epsilon subdivisions,2WJDM@28221|Deltaproteobacteria,2M8QZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM tRNA synthetase class II (D K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_972913_1	1121033.AUCF01000024_gene253	3.26e-66	211.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TT5Y@28211|Alphaproteobacteria,2JVDN@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_972913_2	1280390.CBQR020000159_gene4224	1.05e-08	58.2	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,4HNHG@91061|Bacilli,26XFT@186822|Paenibacillaceae	91061|Bacilli	T	Belongs to the universal stress protein A family	uspA	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_188182_1	177439.DP0898	1.09e-69	226.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2MHSH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,R3H
k59_91407_1	1219031.BBJR01000074_gene942	1.22e-07	52.4	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2VRD3@28216|Betaproteobacteria,4ADP4@80864|Comamonadaceae	28216|Betaproteobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_91407_2	535289.Dtpsy_2841	1.27e-58	197.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,4AAEI@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_842658_1	572547.Amico_1776	3.8e-46	154.0	COG1970@1|root,COG1970@2|Bacteria,3TCAP@508458|Synergistetes	508458|Synergistetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_842658_2	305700.B447_05700	4.94e-39	134.0	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,2VQ18@28216|Betaproteobacteria,2KW3V@206389|Rhodocyclales	206389|Rhodocyclales	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
k59_940249_1	1000565.METUNv1_01676	3.03e-13	67.0	COG0791@1|root,COG0791@2|Bacteria,1NA3R@1224|Proteobacteria,2VXXX@28216|Betaproteobacteria	28216|Betaproteobacteria	M	to Bacteriophage D3 Orf25 SWALL Q9MC96 (EMBL AF165214) (135 aa) fasta scores E() 0.00047, 30.46 id in 128 aa	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
k59_712936_1	478749.BRYFOR_08075	5.1e-12	69.3	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_745373_1	1476876.JOJO01000007_gene2348	2.87e-31	123.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_26705_1	945713.IALB_1310	4.56e-75	239.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_613893_1	945713.IALB_2319	1.73e-14	78.2	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_537195_1	29581.BW37_02553	2.04e-95	306.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,472BY@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_680190_1	926569.ANT_18620	9.43e-46	157.0	COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_680190_2	70448.A0A090M0P8	2.39e-06	52.4	KOG4441@1|root,KOG4441@2759|Eukaryota,37V3T@33090|Viridiplantae	33090|Viridiplantae	T	Kelch motif	-	-	-	ko:K10447	ko04120,map04120	-	-	-	ko00000,ko00001,ko04121	-	-	-	Kelch_1
k59_352586_1	767029.HMPREF9154_2277	4.87e-15	69.3	COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,4DQJR@85009|Propionibacteriales	201174|Actinobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_352586_2	1410632.JHWW01000001_gene1162	1.13e-23	96.3	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,27J5B@186928|unclassified Lachnospiraceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_317965_1	398527.Bphyt_6117	3.99e-91	276.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2VIM3@28216|Betaproteobacteria,1K13V@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.46,4.2.1.83	ko:K10220,ko:K14333	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R00821,R04478	RC00390,RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_250697_1	76114.ebA2999	1.39e-06	50.4	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KVA0@206389|Rhodocyclales	206389|Rhodocyclales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_250697_2	864051.BurJ1DRAFT_0312	1.6e-45	152.0	COG3312@1|root,COG3312@2|Bacteria,1RJ13@1224|Proteobacteria,2VT87@28216|Betaproteobacteria,1KM6R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_352598_1	443143.GM18_1652	8.01e-18	89.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42T55@68525|delta/epsilon subdivisions,2WPW2@28221|Deltaproteobacteria,43UYN@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_843587_1	1128421.JAGA01000002_gene1133	9.91e-78	242.0	COG0709@1|root,COG0709@2|Bacteria,2NNUD@2323|unclassified Bacteria	2|Bacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
k59_124341_1	984962.XP_009545253.1	4.73e-05	47.8	COG0476@1|root,KOG2017@2759|Eukaryota,38E2S@33154|Opisthokonta,3NZDJ@4751|Fungi,3UZBZ@5204|Basidiomycota,22708@155619|Agaricomycetes,3H31N@355688|Agaricomycetes incertae sedis	4751|Fungi	H	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl- adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor	cnxF	GO:0000003,GO:0001403,GO:0001558,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007114,GO:0008033,GO:0008150,GO:0008152,GO:0008641,GO:0009451,GO:0009987,GO:0010467,GO:0010570,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0016783,GO:0016874,GO:0016877,GO:0018117,GO:0018175,GO:0019538,GO:0019954,GO:0030447,GO:0032446,GO:0032447,GO:0032505,GO:0033554,GO:0034227,GO:0034470,GO:0034599,GO:0034641,GO:0034660,GO:0036211,GO:0036267,GO:0040007,GO:0040008,GO:0042221,GO:0042292,GO:0043170,GO:0043412,GO:0044182,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051301,GO:0051716,GO:0065007,GO:0070566,GO:0070647,GO:0070733,GO:0070783,GO:0070784,GO:0070887,GO:0071704,GO:0090304,GO:1900428,GO:1901360,GO:1901564,GO:2000220	2.7.7.80,2.8.1.11	ko:K11996	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000,ko03016,ko04121	-	-	-	Rhodanese,ThiF
k59_124341_2	1173023.KE650771_gene3894	2.84e-15	76.6	COG0725@1|root,COG0725@2|Bacteria,1G0VZ@1117|Cyanobacteria,1JH7G@1189|Stigonemataceae	1117|Cyanobacteria	P	Bacterial extracellular solute-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	iJN678.modA	SBP_bac_11
k59_124342_1	1121875.KB907553_gene20	1.33e-37	138.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_124342_2	1089551.KE386572_gene381	1.67e-34	129.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_1024943_1	323097.Nham_3859	1.19e-35	132.0	COG0582@1|root,COG0582@2|Bacteria,1MXUB@1224|Proteobacteria,2U4UD@28211|Alphaproteobacteria,3K2QR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Integrase_1,Phage_int_SAM_2
k59_680212_1	870187.Thini_0434	7.23e-22	93.2	COG3293@1|root,2ZJP3@2|Bacteria,1N918@1224|Proteobacteria,1T83V@1236|Gammaproteobacteria,463DF@72273|Thiotrichales	72273|Thiotrichales	L	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4
k59_680212_2	118173.KB235911_gene102	5.4e-22	88.2	2B9V1@1|root,32380@2|Bacteria,1GGKW@1117|Cyanobacteria,1HGRP@1150|Oscillatoriales	1117|Cyanobacteria	S	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4
k59_189073_1	338963.Pcar_1869	8.19e-80	246.0	COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2WIRR@28221|Deltaproteobacteria,43S9X@69541|Desulfuromonadales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_250706_1	1408419.JHYG01000025_gene110	8.67e-103	304.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U0EE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_1030958_1	882083.SacmaDRAFT_4010	5.78e-39	142.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4E0BP@85010|Pseudonocardiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_545320_1	243277.VC_A0221	3.89e-48	166.0	COG1075@1|root,COG1075@2|Bacteria,1NB6J@1224|Proteobacteria,1RS95@1236|Gammaproteobacteria,1XSSG@135623|Vibrionales	135623|Vibrionales	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	hlyC	GO:0003674,GO:0003824,GO:0004806,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0052689,GO:0071704,GO:1901575	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
k59_545320_2	1177179.A11A3_03042	6.39e-13	69.7	COG5380@1|root,COG5380@2|Bacteria,1MZT4@1224|Proteobacteria,1SFFG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Lipase chaperone	lipH	-	-	-	-	-	-	-	-	-	-	-	Lipase_chap
k59_797892_1	868595.Desca_2390	7.99e-33	118.0	COG0778@1|root,COG0778@2|Bacteria,1V3YJ@1239|Firmicutes,24MER@186801|Clostridia,266UI@186807|Peptococcaceae	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_489223_1	1038869.AXAN01000111_gene2969	1.22e-50	169.0	COG1075@1|root,COG1075@2|Bacteria,1NIPT@1224|Proteobacteria,2W3DE@28216|Betaproteobacteria,1K60G@119060|Burkholderiaceae	28216|Betaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_489239_1	640081.Dsui_0602	6.47e-52	172.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,2KUUS@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_489239_2	159450.NH14_12305	3.5e-13	67.8	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,1JZTS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_797910_1	479434.Sthe_3192	1.86e-42	156.0	COG0843@1|root,COG0843@2|Bacteria,2G628@200795|Chloroflexi,27YW1@189775|Thermomicrobia	189775|Thermomicrobia	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_261091_1	269796.Rru_A2404	1.06e-97	291.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,2TSV4@28211|Alphaproteobacteria,2JRA2@204441|Rhodospirillales	204441|Rhodospirillales	G	Phosphoribulokinase	cbbP	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_286004_1	76114.ebA5023	4.36e-59	189.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2VS28@28216|Betaproteobacteria,2KWAK@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome B561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_261162_1	1231391.AMZF01000038_gene560	5.86e-22	96.3	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VPSG@28216|Betaproteobacteria,3T46X@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_798007_1	999423.HMPREF9161_00527	9.09e-57	196.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H2BH@909932|Negativicutes	909932|Negativicutes	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_261176_1	1279019.ARQK01000012_gene147	7.68e-58	192.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales	135613|Chromatiales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_261176_2	748658.KB907313_gene2137	9.55e-68	216.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1WXDA@135613|Chromatiales	135613|Chromatiales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_798021_1	999541.bgla_1g06450	1.85e-41	139.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,1K7SV@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_798021_2	983917.RGE_04500	8.66e-18	82.4	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,1KJEI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_545461_1	543728.Vapar_2819	2.03e-82	248.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,4ABQK@80864|Comamonadaceae	28216|Betaproteobacteria	C	cytochrome c oxidase, cbb3-type, subunit II	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_1031060_1	1094553.MCS_00106	2.76e-72	226.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria,48TSP@772|Bartonellaceae	28211|Alphaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1031060_2	648757.Rvan_0077	2.91e-26	102.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,3N8U2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_545475_1	640081.Dsui_0987	2.86e-58	190.0	COG0491@1|root,COG0491@2|Bacteria,1NCIF@1224|Proteobacteria,2VJVR@28216|Betaproteobacteria,2KV3A@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_489413_1	234621.RER_04400	1.49e-29	113.0	COG1073@1|root,COG1073@2|Bacteria,2GNB6@201174|Actinobacteria,4FXHV@85025|Nocardiaceae	201174|Actinobacteria	S	Protein involved in hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	AXE1,Abhydrolase_1,Peptidase_S15
k59_489413_2	1304275.C41B8_10248	1.31e-81	250.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,1RP40@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	gluconolactonase	gnl	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_545517_1	1205680.CAKO01000011_gene1	1.84e-18	87.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2JQAX@204441|Rhodospirillales	204441|Rhodospirillales	V	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_286138_1	330214.NIDE4318	8.91e-89	288.0	COG1197@1|root,COG1197@2|Bacteria,3J0BA@40117|Nitrospirae	40117|Nitrospirae	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_798109_2	748247.AZKH_0332	1.26e-10	64.3	2CJJV@1|root,30VBX@2|Bacteria,1RGSF@1224|Proteobacteria,2VS5D@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_489477_1	1144275.COCOR_06362	2.74e-70	237.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,42NU9@68525|delta/epsilon subdivisions,2WKXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
k59_545559_1	1089552.KI911559_gene2518	7.07e-28	110.0	COG1575@1|root,COG1575@2|Bacteria	2|Bacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_545559_2	1089552.KI911559_gene2517	2.6e-31	118.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,2JRCB@204441|Rhodospirillales	204441|Rhodospirillales	S	Elongator protein 3, MiaB family, Radical SAM	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_489517_1	1156937.MFUM_260030	3.99e-49	167.0	COG0372@1|root,COG0372@2|Bacteria,46SBV@74201|Verrucomicrobia,37G5R@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_545575_1	1288494.EBAPG3_1920	3.33e-81	255.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2VHXK@28216|Betaproteobacteria,371WQ@32003|Nitrosomonadales	28216|Betaproteobacteria	C	MOFRL family	ttuD2	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_1031152_1	945713.IALB_0792	6.36e-14	73.2	COG0404@1|root,COG0404@2|Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_1031152_2	316274.Haur_3694	2.5e-18	81.6	COG2096@1|root,COG2096@2|Bacteria,2G6TB@200795|Chloroflexi,3777D@32061|Chloroflexia	32061|Chloroflexia	S	PFAM cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_545604_1	1100721.ALKO01000003_gene1968	9.48e-52	180.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4AAHM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_798199_2	106648.BBLJ01000001_gene2177	1.03e-08	61.6	COG3188@1|root,COG3188@2|Bacteria,1MWV6@1224|Proteobacteria,1RNWK@1236|Gammaproteobacteria,3NKPQ@468|Moraxellaceae	1236|Gammaproteobacteria	NU	Outer membrane usher protein	csuD	-	-	ko:K07347	ko05133,map05133	-	-	-	ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3	-	-	PapC_C,Usher
k59_1031171_1	1229909.NSED_07985	4.2e-42	149.0	COG1690@1|root,arCOG04246@2157|Archaea,41SE4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1031171_2	436308.Nmar_1452	2.28e-37	129.0	arCOG05529@1|root,arCOG05529@2157|Archaea,41SSJ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	dsDNA_bind
k59_798220_1	278957.ABEA03000041_gene2203	1.89e-18	89.4	COG4166@1|root,COG4166@2|Bacteria,46ZJQ@74201|Verrucomicrobia,3K79R@414999|Opitutae	414999|Opitutae	E	PFAM extracellular solute-binding protein family 5	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_489610_2	292415.Tbd_2232	5.25e-38	140.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,1KRGU@119069|Hydrogenophilales	119069|Hydrogenophilales	M	MltA specific insert domain	-	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
k59_545654_2	580332.Slit_0684	1.5e-47	164.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria,44VE0@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	PFAM Type II secretion system F domain	pilC2	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_545696_1	338963.Pcar_1381	8.71e-90	272.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,42MM6@68525|delta/epsilon subdivisions,2WJ53@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_798287_2	1120983.KB894577_gene3576	1.7e-114	340.0	COG1052@1|root,COG1052@2|Bacteria,1REXX@1224|Proteobacteria,2U1NZ@28211|Alphaproteobacteria,1JQNJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.28,1.1.1.29,1.1.1.399,1.1.1.95	ko:K00018,ko:K00058,ko:K03778	ko00260,ko00620,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00620,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020,M00346	R00704,R00717,R01388,R01513	RC00031,RC00042,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_798298_1	96561.Dole_0605	4.44e-20	89.4	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2WIMV@28221|Deltaproteobacteria,2MK32@213118|Desulfobacterales	28221|Deltaproteobacteria	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
k59_798298_2	1121405.dsmv_0482	0.000687	42.4	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,2MK6Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_552907_1	349521.HCH_03194	7.37e-20	97.4	COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1T42Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	outer membrane autotransporter barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
k59_552913_1	269799.Gmet_0984	1.52e-104	315.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,43TSY@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Carbamoyl-phosphate synthetase large chain domain protein	accC	-	6.3.4.14,6.4.1.1,6.4.1.2	ko:K01959,ko:K01961	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376,M00620	R00344,R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_552924_1	187272.Mlg_0001	5.89e-107	320.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1037030_1	420662.Mpe_A1230	1.24e-53	172.0	COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,2W30E@28216|Betaproteobacteria,1KNKV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
k59_1037042_2	153948.NAL212_2360	4.01e-55	178.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2VSJY@28216|Betaproteobacteria,3735C@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	yjeE	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
k59_1037042_3	1057002.KB905370_gene1033	5.86e-54	172.0	COG3791@1|root,COG3791@2|Bacteria,1RBIH@1224|Proteobacteria,2U5D0@28211|Alphaproteobacteria,4BEY0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_1037064_1	857087.Metme_0555	4.47e-84	258.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1XE4U@135618|Methylococcales	135618|Methylococcales	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	-
k59_1037089_1	1109445.AGSX01000196_gene572	1.06e-20	94.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1Z1W6@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	NU	general secretion pathway protein D	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	SPOR,Secretin,Secretin_N
k59_1037089_2	717774.Marme_3371	5.53e-09	58.9	COG3031@1|root,COG3031@2|Bacteria,1RK5N@1224|Proteobacteria,1S7YM@1236|Gammaproteobacteria,1XKFU@135619|Oceanospirillales	135619|Oceanospirillales	U	Type II secretion system protein C	-	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSC
k59_806209_1	1265502.KB905935_gene3112	2.83e-73	227.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,4ACD3@80864|Comamonadaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_553080_1	1123368.AUIS01000028_gene1320	8.29e-67	218.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,2NBYN@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_553080_2	1121035.AUCH01000009_gene833	1.56e-24	94.4	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,2VVQK@28216|Betaproteobacteria,2KX0P@206389|Rhodocyclales	206389|Rhodocyclales	KL	Belongs to the transcriptional regulatory Fis family	-	-	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
k59_553080_3	380358.XALC_2785	3.58e-15	75.5	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1X3G9@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_1037148_1	1123393.KB891327_gene276	5.78e-13	68.9	COG3821@1|root,COG3821@2|Bacteria,1PPR3@1224|Proteobacteria,2VR42@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function, DUF599	-	-	-	-	-	-	-	-	-	-	-	-	DUF599
k59_1037162_1	531844.FIC_01480	4.86e-46	163.0	2DBAQ@1|root,2Z848@2|Bacteria,4NFR9@976|Bacteroidetes,1HXK7@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_553120_1	1218084.BBJK01000075_gene5239	2.87e-30	124.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,2VXDK@28216|Betaproteobacteria,1K5E1@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
k59_806400_1	1288494.EBAPG3_2530	2.34e-37	135.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2VJ6C@28216|Betaproteobacteria,372X4@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_806451_1	13333.ERN06805	3.26e-25	105.0	COG1028@1|root,KOG1200@2759|Eukaryota,37J83@33090|Viridiplantae,3GAYA@35493|Streptophyta	35493|Streptophyta	Q	3-oxoacyl- acyl-carrier-protein reductase	-	GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0031967,GO:0031975,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0055114	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_806473_1	370438.PTH_0458	6.61e-05	45.1	COG0683@1|root,COG0683@2|Bacteria,1V4XA@1239|Firmicutes,24JG7@186801|Clostridia,261AP@186807|Peptococcaceae	186801|Clostridia	E	PFAM Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_806484_1	744979.R2A130_0159	4.44e-39	153.0	COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2TTAQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	xsc	-	2.3.3.15	ko:K03852	ko00430,map00430	-	R05651	RC02903,RC02909	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1037282_1	1410620.SHLA_8c001120	5.93e-08	59.3	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,4B9SM@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_553292_1	330214.NIDE1360	7.99e-69	222.0	COG0004@1|root,COG0004@2|Bacteria,3J0IS@40117|Nitrospirae	40117|Nitrospirae	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_553346_1	584708.Apau_0285	3.45e-17	85.9	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,3TAI7@508458|Synergistetes	508458|Synergistetes	S	Uncharacterised conserved protein (DUF2156)	-	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156,LPG_synthase_TM
k59_806545_1	391626.OAN307_c27180	1.77e-47	166.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Permease, YjgP YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_806586_1	1125863.JAFN01000001_gene2545	7.95e-81	257.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_661925_1	1122604.JONR01000010_gene3993	1.72e-16	78.6	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1X3RT@135614|Xanthomonadales	135614|Xanthomonadales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_661925_2	1123504.JQKD01000024_gene279	2.74e-43	153.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,4A9X8@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_41242_1	85643.Tmz1t_2648	2.33e-178	522.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_464040_3	344747.PM8797T_27949	3.09e-49	160.0	COG3436@1|root,COG3436@2|Bacteria	2|Bacteria	L	PFAM IS66 Orf2 family protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_987641_1	1150600.ADIARSV_2527	7.45e-100	308.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,4NFAW@976|Bacteroidetes,1IPNB@117747|Sphingobacteriia	976|Bacteroidetes	KOT	response regulator, receiver	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2,Response_reg
k59_398916_1	756067.MicvaDRAFT_0213	7.41e-65	231.0	COG2114@1|root,COG2202@1|root,COG2203@1|root,COG3852@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3852@2|Bacteria,1FZXP@1117|Cyanobacteria,1H7QI@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	GAF_2,Guanylate_cyc,PAS,PAS_8,PAS_9
k59_106692_1	1265505.ATUG01000001_gene4412	8.38e-68	218.0	COG2984@1|root,COG2984@2|Bacteria,1PHRH@1224|Proteobacteria,4372G@68525|delta/epsilon subdivisions,2X1VK@28221|Deltaproteobacteria,2MP1Q@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
k59_889393_1	522306.CAP2UW1_3162	1.45e-30	115.0	COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,2VMF3@28216|Betaproteobacteria	28216|Betaproteobacteria	L	COG3436 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66
k59_889394_1	1123008.KB905701_gene2172	2.1e-51	182.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia,22XI5@171551|Porphyromonadaceae	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_498739_1	1123367.C666_12810	4.22e-19	85.9	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KV7X@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_498739_2	1000565.METUNv1_03813	2.51e-53	170.0	COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,2VT09@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the thioredoxin family	trxC	-	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
k59_661947_1	1535422.ND16A_2175	1.5e-61	206.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2Q64M@267889|Colwelliaceae	1236|Gammaproteobacteria	U	AAA domain	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1,T2SSB
k59_857211_1	1121935.AQXX01000141_gene2027	3.23e-20	95.5	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1XJ5F@135619|Oceanospirillales	135619|Oceanospirillales	NU	Tfp pilus assembly protein tip-associated adhesin PilY1	-	-	-	-	-	-	-	-	-	-	-	-	Neisseria_PilC
k59_1016006_1	313603.FB2170_10556	2.33e-73	235.0	COG2114@1|root,COG2114@2|Bacteria,4NG5A@976|Bacteroidetes,1HYY0@117743|Flavobacteriia,2PIRQ@252356|Maribacter	976|Bacteroidetes	T	Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_596376_1	330214.NIDE0993	2.52e-88	268.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_235647_1	75379.Tint_1794	1.88e-76	238.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,2VPNY@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_269848_1	335543.Sfum_2204	2.49e-05	51.6	COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2MQDN@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	Stage II sporulation	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
k59_694661_1	1157708.KB907455_gene3403	2.61e-08	56.2	COG2353@1|root,COG2353@2|Bacteria,1RJFZ@1224|Proteobacteria,2VQHC@28216|Betaproteobacteria,4ADGG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_694661_2	1177928.TH2_19774	9.05e-31	115.0	COG4232@1|root,COG4232@2|Bacteria,1RG8V@1224|Proteobacteria,2U88V@28211|Alphaproteobacteria,2JVNI@204441|Rhodospirillales	204441|Rhodospirillales	CO	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_889396_1	1266925.JHVX01000013_gene1613	0.0	1011.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales	28216|Betaproteobacteria	CEH	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_596379_1	631362.Thi970DRAFT_03499	6.51e-159	451.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1WWCV@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_171956_1	1454004.AW11_02015	4.03e-141	445.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_757887_1	926556.Echvi_3306	2.98e-62	206.0	COG3547@1|root,COG3547@2|Bacteria,4NJ8G@976|Bacteroidetes,47U5R@768503|Cytophagia	976|Bacteroidetes	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_498764_1	688245.CtCNB1_1818	1.48e-49	166.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,4ABIC@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator crp fnr family	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_628903_1	1247963.JPHU01000007_gene1655	7.23e-74	242.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TTAX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Prolyl oligopeptidase	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_889406_1	279714.FuraDRAFT_2222	5.93e-34	119.0	COG0640@1|root,COG0640@2|Bacteria,1MZPS@1224|Proteobacteria,2VUHJ@28216|Betaproteobacteria,2KU2N@206351|Neisseriales	206351|Neisseriales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_889406_2	159450.NH14_24605	2.14e-42	152.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHQD@28216|Betaproteobacteria,1K09N@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde dehydrogenase	betB	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_335091_1	345073.VC395_0340	2.22e-09	57.8	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1XWV0@135623|Vibrionales	135623|Vibrionales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_464997_1	864051.BurJ1DRAFT_1493	2.31e-33	120.0	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,2VWT7@28216|Betaproteobacteria,1KMAS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_826312_1	1139996.OMQ_02580	1.33e-13	70.5	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,4H9NP@91061|Bacilli,4AZEF@81852|Enterococcaceae	91061|Bacilli	F	Pyrimidine nucleoside phosphorylase C-terminal domain	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_826312_2	530564.Psta_4707	1.14e-17	82.8	COG0173@1|root,COG0173@2|Bacteria,2IX6U@203682|Planctomycetes	203682|Planctomycetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_629936_1	1077974.GOEFS_121_00430	7.67e-08	59.3	COG0668@1|root,COG0668@2|Bacteria,2HD92@201174|Actinobacteria,4GFN5@85026|Gordoniaceae	201174|Actinobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_368534_1	323848.Nmul_A0855	1.2e-102	310.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,371UM@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	odhL	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_597463_2	530564.Psta_3872	7.17e-59	189.0	COG0745@1|root,COG0745@2|Bacteria,2IZ9J@203682|Planctomycetes	203682|Planctomycetes	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_270896_1	305700.B447_05258	1.81e-109	328.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,2KVYE@206389|Rhodocyclales	206389|Rhodocyclales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_433719_1	1121937.AUHJ01000045_gene1233	1.13e-29	117.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria,468CJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_29,rve
k59_695786_1	1249627.D779_0079	3.7e-68	218.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_695788_1	557598.LHK_00732	1.08e-59	196.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,2KPEC@206351|Neisseriales	206351|Neisseriales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_758848_1	138119.DSY1297	9.81e-14	77.0	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia,26246@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_236604_2	1110702.G8GIS0_9CAUD	4.4e-43	158.0	4QHQR@10239|Viruses,4QWRJ@35237|dsDNA viruses  no RNA stage,4QSV7@28883|Caudovirales,4QKFT@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_173084_1	1121405.dsmv_3403	2.64e-85	264.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2MHV9@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_988713_1	999549.KI421513_gene872	6.3e-05	45.1	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,280FD@191028|Leisingera	28211|Alphaproteobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_988713_2	488538.SAR116_1460	5.77e-72	228.0	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,4BRDF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system permease	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_758857_1	945713.IALB_0228	1.27e-115	338.0	COG0113@1|root,COG0113@2|Bacteria	2|Bacteria	H	porphobilinogen synthase activity	hemB	GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477	ALAD
k59_140458_1	257310.BB2690	1.83e-144	423.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,3T1XI@506|Alcaligenaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_565063_1	572477.Alvin_2888	4.35e-90	281.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1WVY3@135613|Chromatiales	135613|Chromatiales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_988723_1	1121405.dsmv_1877	2.57e-30	119.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,42NT5@68525|delta/epsilon subdivisions,2WIWR@28221|Deltaproteobacteria,2MHQV@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	alkK	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_173101_1	690850.Desaf_0026	6.16e-40	140.0	COG3293@1|root,COG3293@2|Bacteria,1R5NV@1224|Proteobacteria,430FR@68525|delta/epsilon subdivisions,2WVKI@28221|Deltaproteobacteria,2MFEK@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_663062_2	1283300.ATXB01000002_gene2887	5.41e-103	310.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
k59_758868_1	1123237.Salmuc_02695	2.99e-53	181.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_956722_2	1121035.AUCH01000013_gene3147	7.01e-93	286.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,2KUJQ@206389|Rhodocyclales	206389|Rhodocyclales	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_890454_1	395495.Lcho_1543	5.69e-71	244.0	COG1729@1|root,COG1729@2|Bacteria,1MZ7N@1224|Proteobacteria,2VNYC@28216|Betaproteobacteria,1KN2J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_205501_1	1163617.SCD_n00571	4.08e-08	54.3	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	type II secretion system protein E	xcpR	-	-	ko:K02454,ko:K02652,ko:K12276	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_205501_2	1236959.BAMT01000006_gene247	8.07e-59	196.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria,2KKSQ@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_528919_1	1157708.KB907462_gene897	3.9e-78	245.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,4AB2U@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_75418_1	436308.Nmar_1598	1.71e-57	180.0	arCOG08790@1|root,arCOG08790@2157|Archaea,41SWN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_597503_1	1485544.JQKP01000015_gene2088	2.99e-31	110.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,44WMA@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Sulfurtransferase TusA	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_597503_2	1123393.KB891327_gene473	3.73e-49	163.0	COG2210@1|root,COG2210@2|Bacteria,1QCK1@1224|Proteobacteria,2WE8S@28216|Betaproteobacteria,1KSAI@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_173112_2	1120999.JONM01000021_gene124	1.95e-15	78.6	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VJ8W@28216|Betaproteobacteria,2KPFK@206351|Neisseriales	206351|Neisseriales	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_399920_1	1408303.JNJJ01000077_gene4291	4.14e-26	111.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,4H9P7@91061|Bacilli,1ZBC6@1386|Bacillus	91061|Bacilli	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
k59_368591_1	436308.Nmar_0273	5.38e-107	322.0	COG0439@1|root,arCOG01590@2157|Archaea,41SXC@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Carbamoyl-phosphate synthase L chain	-	-	6.4.1.2,6.4.1.3	ko:K18603	ko00720,ko01120,map00720,map01120	-	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_336219_1	1532557.JL37_10620	6.6e-50	164.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2VJ98@28216|Betaproteobacteria,3T3KY@506|Alcaligenaceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_336219_2	264198.Reut_A0483	1.14e-76	238.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,1K2TQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_509319_1	268407.PWYN_18725	8.15e-06	49.3	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UZKW@1239|Firmicutes,4HF1S@91061|Bacilli,26T48@186822|Paenibacillaceae	91061|Bacilli	T	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
k59_509319_2	1128421.JAGA01000002_gene232	2.22e-31	127.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_606825_1	1268622.AVS7_01903	2.35e-18	86.3	COG3181@1|root,COG3181@2|Bacteria,1R748@1224|Proteobacteria,2VKDU@28216|Betaproteobacteria,4AGUQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_606825_2	1125973.JNLC01000010_gene1417	8.3e-20	88.2	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,3JZ96@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_574610_1	1121904.ARBP01000012_gene1362	1.49e-63	217.0	COG0464@1|root,COG0464@2|Bacteria,4NJBD@976|Bacteroidetes,47P4W@768503|Cytophagia	976|Bacteroidetes	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_966435_1	1191523.MROS_0285	2.2e-52	186.0	2E09V@1|root,32VXB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_574613_1	1454004.AW11_02732	1.22e-53	178.0	2C7Q9@1|root,2Z96K@2|Bacteria,1MWKA@1224|Proteobacteria,2VN2M@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_574613_2	1244869.H261_06489	2.96e-05	46.6	COG0656@1|root,COG0656@2|Bacteria,1MWFS@1224|Proteobacteria,2TT2Q@28211|Alphaproteobacteria,2JUV5@204441|Rhodospirillales	204441|Rhodospirillales	S	Aldo/keto reductase family	-	-	1.1.1.346	ko:K06221	-	-	R08878	RC00089	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_117267_1	768671.ThimaDRAFT_2892	1.43e-24	102.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1WXVN@135613|Chromatiales	135613|Chromatiales	G	PfkB domain protein	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_117267_2	32057.KB217478_gene205	2.38e-22	95.1	COG0366@1|root,COG0366@2|Bacteria,1G0QI@1117|Cyanobacteria,1HTY7@1161|Nostocales	1117|Cyanobacteria	G	Glycogen debranching enzyme, glucanotransferase domain	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_606836_1	375286.mma_1293	1.44e-117	352.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,476BH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_472846_1	330214.NIDE0950	1.22e-58	186.0	COG0537@1|root,COG0537@2|Bacteria	2|Bacteria	FG	bis(5'-adenosyl)-triphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	HIT
k59_966450_1	1265505.ATUG01000001_gene3442	5.13e-85	257.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_606844_1	714961.BFZC1_23843	5.32e-20	96.7	COG0642@1|root,COG2205@2|Bacteria,1TS12@1239|Firmicutes,4HC66@91061|Bacilli,3IXJY@400634|Lysinibacillus	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_837205_5	1192124.LIG30_3851	1.21e-45	152.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1K4S6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_934918_1	933262.AXAM01000009_gene1491	1e-120	367.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,42NNE@68525|delta/epsilon subdivisions,2WJZX@28221|Deltaproteobacteria,2MI6X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	qmoB	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_9,FlpD,Pyr_redox_2
k59_378510_2	903818.KI912268_gene1621	1.63e-34	125.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	yafV	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0030312,GO:0044464,GO:0050152,GO:0071944,GO:0106008	3.5.1.3,3.5.1.77,3.5.5.1	ko:K01459,ko:K01501,ko:K11206,ko:K13566	ko00250,ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00250,map00380,map00460,map00627,map00643,map00910,map01120	-	R00269,R00348,R00540,R01887,R03093,R03542,R05591,R07855	RC00010,RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,CN_hydrolase
k59_673880_2	1288826.MSNKSG1_15911	3.05e-23	98.6	COG4665@1|root,COG4665@2|Bacteria,1RE14@1224|Proteobacteria,1S582@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG4665 TRAP-type mannitol chloroaromatic compound transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_443858_1	29495.EA26_00670	1.09e-08	51.2	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,1XYVN@135623|Vibrionales	135623|Vibrionales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
k59_443858_2	1116472.MGMO_223c00090	1.12e-17	84.3	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1XDZC@135618|Methylococcales	135618|Methylococcales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_151011_1	83406.HDN1F_06470	3.61e-09	56.6	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1J8M1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Sulfate adenylate transferase	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_312502_1	1433126.BN938_0963	1.16e-07	58.2	COG3274@1|root,COG3274@2|Bacteria,4NP3U@976|Bacteroidetes,2FNDR@200643|Bacteroidia,22VSW@171550|Rikenellaceae	976|Bacteroidetes	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_837219_2	443152.MDG893_05289	9.72e-38	143.0	COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_473728_1	1121090.KB894688_gene1875	6.89e-15	78.6	COG0697@1|root,COG0697@2|Bacteria,1V230@1239|Firmicutes,4HPYF@91061|Bacilli,1ZJIY@1386|Bacillus	91061|Bacilli	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
k59_790662_1	1459636.NTE_03061	1.09e-72	226.0	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1021795_1	745310.G432_10020	3.66e-67	216.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2K12N@204457|Sphingomonadales	204457|Sphingomonadales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_575691_1	1158292.JPOE01000005_gene373	2.32e-85	253.0	COG3415@1|root,COG3415@2|Bacteria,1RFJE@1224|Proteobacteria,2VV16@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
k59_151029_1	1454004.AW11_01591	6.78e-87	265.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,1KQBQ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
k59_934945_1	323848.Nmul_A2685	1.04e-108	323.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2VJ3T@28216|Betaproteobacteria,372CI@32003|Nitrosomonadales	28216|Betaproteobacteria	GM	PFAM NAD-dependent epimerase dehydratase	yeeZ	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind,TrkA_N
k59_607911_2	396588.Tgr7_3254	1.83e-82	253.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales	135613|Chromatiales	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_378530_1	1384056.N787_05910	3.86e-11	60.1	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,1X7J1@135614|Xanthomonadales	135614|Xanthomonadales	U	Preprotein translocase subunit YajC	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_378530_2	1131553.JIBI01000069_gene1894	3.59e-85	261.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,372EF@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_868620_1	999541.bgla_1g02330	6.37e-12	63.5	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,1K982@119060|Burkholderiaceae	28216|Betaproteobacteria	C	cytochrome C	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
k59_868620_2	159087.Daro_3859	3.59e-07	52.8	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,2KWMI@206389|Rhodocyclales	206389|Rhodocyclales	C	cytochrome c5	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_408649_1	1384056.N787_01665	7.34e-98	300.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1X64I@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
k59_215748_1	94624.Bpet3948	2.64e-72	229.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2VMPR@28216|Betaproteobacteria,3T6V0@506|Alcaligenaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	idnD	-	1.1.1.264	ko:K00098	-	-	R05684	RC00089	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_443890_1	1380394.JADL01000004_gene5920	2.78e-81	257.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria,2JQW6@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	-	-	-	-	-	-	-	-	-	-	G_glu_transpept
k59_473749_3	653045.Strvi_3576	4.97e-20	91.3	COG4249@1|root,COG4249@2|Bacteria,2IB3R@201174|Actinobacteria	201174|Actinobacteria	M	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_C14
k59_900341_2	436308.Nmar_0891	1.41e-43	143.0	arCOG10560@1|root,arCOG10560@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_837252_1	1123360.thalar_02885	9.56e-74	238.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_868651_1	95619.PM1_0217250	1.04e-30	112.0	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the ArsC family	yffB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
k59_52677_1	667632.KB890194_gene3502	1.14e-44	169.0	COG0840@1|root,COG4251@1|root,COG0840@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VJGY@28216|Betaproteobacteria,1KGEK@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA,PAS,PAS_9,TarH
k59_86142_1	1163617.SCD_n00511	1.06e-130	395.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_20713_1	1032480.MLP_10090	2.43e-07	51.6	COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4DNK5@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	fadE19	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.1,1.3.99.12	ko:K00248,ko:K11410	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_20713_2	1232437.KL661988_gene288	1.69e-38	135.0	COG1813@1|root,COG1917@1|root,COG1813@2|Bacteria,COG1917@2|Bacteria,1R8QC@1224|Proteobacteria,42NJP@68525|delta/epsilon subdivisions,2WMAB@28221|Deltaproteobacteria,2MIRS@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
k59_118393_1	436114.SYO3AOP1_1203	2.84e-46	160.0	COG0568@1|root,COG0568@2|Bacteria,2G3PM@200783|Aquificae	200783|Aquificae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoS	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_378558_1	643562.Daes_0729	8.74e-36	132.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2WNS9@28221|Deltaproteobacteria,2MA33@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM VacJ family lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_151062_1	1411123.JQNH01000001_gene886	1e-35	135.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_151062_2	697282.Mettu_0212	3.39e-13	70.1	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,1XFGU@135618|Methylococcales	135618|Methylococcales	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
k59_837268_1	1537994.JQFW01000006_gene3051	2.56e-72	233.0	COG0446@1|root,COG0446@2|Bacteria,1Q0P8@1224|Proteobacteria,1T1NQ@1236|Gammaproteobacteria,464PV@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Tryptophan halogenase	-	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
k59_408679_1	1123354.AUDR01000014_gene958	6.43e-72	228.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,1KS4K@119069|Hydrogenophilales	119069|Hydrogenophilales	H	RibD C-terminal domain	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_312554_1	420662.Mpe_A3139	0.000948	42.4	2EUAF@1|root,33MSV@2|Bacteria,1NIMQ@1224|Proteobacteria,2VZ17@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_215779_1	1163617.SCD_n00049	1.63e-123	379.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_215779_2	1031711.RSPO_c01196	0.000713	45.1	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,1K2PD@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_868665_1	1229909.NSED_00835	1.72e-69	223.0	COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Vinylacetyl-CoA Delta-isomerase	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
k59_868665_2	1229909.NSED_00830	9.93e-22	93.2	COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18593	ko00720,ko01120,map00720,map01120	-	R10758	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_967604_1	717785.HYPMC_4673	4.34e-88	265.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,3N6KD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_20723_1	889378.Spiaf_0116	2.06e-76	260.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2J5ZA@203691|Spirochaetes	203691|Spirochaetes	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_443927_1	500640.CIT292_06422	2.97e-59	191.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,1RPKU@1236|Gammaproteobacteria,3WXEN@544|Citrobacter	1236|Gammaproteobacteria	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	GO:0003674,GO:0005215,GO:0005372,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006833,GO:0006884,GO:0006950,GO:0006970,GO:0008150,GO:0008361,GO:0009628,GO:0009987,GO:0009992,GO:0015250,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042044,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0050896,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_312557_1	644282.Deba_2635	3.85e-28	110.0	2EFDI@1|root,3396C@2|Bacteria,1N9D7@1224|Proteobacteria,42W2W@68525|delta/epsilon subdivisions,2WR8J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_673958_1	1123367.C666_03700	2.45e-33	120.0	2C0CP@1|root,32SP5@2|Bacteria,1N5DU@1224|Proteobacteria,2VU5I@28216|Betaproteobacteria,2KX2M@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_673958_2	768671.ThimaDRAFT_0814	6.94e-14	70.9	COG0348@1|root,COG0348@2|Bacteria,1MUWD@1224|Proteobacteria,1RZ0Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
k59_868669_1	909663.KI867150_gene2838	1.56e-83	259.0	COG0420@1|root,COG0420@2|Bacteria,1MXMJ@1224|Proteobacteria,42Q5U@68525|delta/epsilon subdivisions,2WINF@28221|Deltaproteobacteria,2MRY7@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Calcineurin-like phosphoesterase superfamily domain	sbcD-1	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
k59_739197_1	1238182.C882_0987	1.26e-81	271.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,2JREK@204441|Rhodospirillales	204441|Rhodospirillales	G	Maltogenic Amylase, C-terminal domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_408686_1	882378.RBRH_01273	8.02e-122	375.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K0Y7@119060|Burkholderiaceae	28216|Betaproteobacteria	L	dna topoisomerase III	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
k59_739198_1	1121456.ATVA01000016_gene2102	1.78e-64	209.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2M8E8@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_900373_1	1242864.D187_002923	1.81e-08	59.3	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42RWK@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_20731_1	1173024.KI912152_gene425	2.98e-62	206.0	COG5659@1|root,COG5659@2|Bacteria,1GDXT@1117|Cyanobacteria	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_20732_1	1502724.FF80_00573	5.7e-98	288.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2TU3T@28211|Alphaproteobacteria,3N6IP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_999080_1	583355.Caka_1879	3.4e-29	120.0	28HMZ@1|root,2Z7WD@2|Bacteria,46TFX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_900377_1	396595.TK90_1993	2.88e-17	84.7	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WX6I@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_378588_1	391735.Veis_1268	3.49e-56	175.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2VSGE@28216|Betaproteobacteria,4AEBX@80864|Comamonadaceae	28216|Betaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_378588_2	987059.RBXJA2T_02140	3.03e-19	80.5	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2VSE6@28216|Betaproteobacteria,1KM24@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_519046_1	1231185.BAMP01000002_gene4357	8.34e-53	185.0	COG3573@1|root,COG3573@2|Bacteria,1MVX8@1224|Proteobacteria,2TVKJ@28211|Alphaproteobacteria,43JC5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	FAD binding domain	MA20_22130	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_943534_1	1408823.AXUS01000002_gene795	1.54e-38	138.0	COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,25R3J@186804|Peptostreptococcaceae	186801|Clostridia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_60661_1	330214.NIDE0904	3.54e-90	271.0	2ERPD@1|root,33J8R@2|Bacteria	2|Bacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
k59_519054_1	402881.Plav_3197	4.78e-61	213.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,1JN3I@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DNA polymerase alpha chain like domain	dnaE	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_386357_2	573370.DMR_27580	2.48e-11	67.0	COG0348@1|root,COG1143@1|root,COG1152@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1152@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2MH2S@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
k59_846019_1	1005048.CFU_2959	5.62e-29	111.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VJ6G@28216|Betaproteobacteria,473QK@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Serine hydrolase (FSH1)	estB	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_224865_1	1229205.BUPH_06423	1.37e-17	79.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2VRJE@28216|Betaproteobacteria,1K75J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
k59_224865_2	1121440.AUMA01000011_gene2422	5.52e-13	66.6	COG2913@1|root,COG2913@2|Bacteria,1N2JT@1224|Proteobacteria,42UGE@68525|delta/epsilon subdivisions,2WW64@28221|Deltaproteobacteria,2MCG6@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
k59_30139_1	1125863.JAFN01000001_gene1826	1.13e-82	247.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2WMP6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_95854_1	870187.Thini_2708	0.000325	44.3	COG0515@1|root,COG0515@2|Bacteria,1QXK0@1224|Proteobacteria,1T3DE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	Pkinase,TIR_2
k59_95854_2	395495.Lcho_3378	2.42e-86	265.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VIRC@28216|Betaproteobacteria,1KJZ9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,SGL
k59_585679_1	305700.B447_17054	2.04e-44	155.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,2KVKS@206389|Rhodocyclales	206389|Rhodocyclales	C	D-amino acid dehydrogenase	dadA	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
k59_585679_2	1121448.DGI_0804	7.57e-17	75.5	COG0662@1|root,COG0662@2|Bacteria,1N1XN@1224|Proteobacteria,42TS2@68525|delta/epsilon subdivisions,2WPZ5@28221|Deltaproteobacteria,2MCQX@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_847182_1	1323663.AROI01000004_gene2115	2.44e-52	174.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P	epmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
k59_847182_2	272624.lpg0287	6.8e-36	127.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1JCR7@118969|Legionellales	118969|Legionellales	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_977515_1	272630.MexAM1_META1p2892	1.11e-71	236.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,1JT21@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_224872_1	222534.KB893761_gene3487	4.15e-07	52.0	COG0160@1|root,COG0160@2|Bacteria,2I2F3@201174|Actinobacteria,4ETTU@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55,4.1.1.64	ko:K00596,ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_716492_1	1122222.AXWR01000023_gene1558	2.16e-82	256.0	COG0458@1|root,COG0458@2|Bacteria	2|Bacteria	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
k59_356097_1	1123392.AQWL01000005_gene3134	1.72e-76	244.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2VMTN@28216|Betaproteobacteria,1KS9H@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Metalloenzyme superfamily	-	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_321123_1	330214.NIDE1584	4.24e-93	284.0	COG3437@1|root,COG3437@2|Bacteria,3J0ID@40117|Nitrospirae	2|Bacteria	T	response regulator	MA20_23615	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
k59_30155_1	1101195.Meth11DRAFT_0463	1.18e-06	52.8	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,2KKBD@206350|Nitrosomonadales	206350|Nitrosomonadales	M	PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
k59_30155_2	1000565.METUNv1_02239	9.7e-34	128.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKJI@28216|Betaproteobacteria,2KVFT@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_253713_1	909663.KI867150_gene34	6.47e-17	82.8	COG3135@1|root,COG3135@2|Bacteria,1MUS1@1224|Proteobacteria,42YVT@68525|delta/epsilon subdivisions,2WU12@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Benzoate membrane transport protein	-	-	-	-	-	-	-	-	-	-	-	-	BenE
k59_716496_1	1121904.ARBP01000005_gene4553	2.35e-123	384.0	COG3378@1|root,COG3378@2|Bacteria,4NE1A@976|Bacteroidetes,47TNG@768503|Cytophagia	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_877924_1	640081.Dsui_3078	5.2e-33	128.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VNJW@28216|Betaproteobacteria,2KW08@206389|Rhodocyclales	206389|Rhodocyclales	NT	Methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
k59_387411_1	1459636.NTE_00598	1.35e-111	327.0	COG0714@1|root,arCOG00441@2157|Archaea,41SDZ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5
k59_585714_1	580332.Slit_2241	3.69e-92	296.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,44WDB@713636|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_847218_1	767434.Fraau_0646	3.91e-41	150.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales	135614|Xanthomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_977544_1	565033.GACE_1599	2.79e-14	80.9	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,245UN@183980|Archaeoglobi	183980|Archaeoglobi	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,Rad50_zn_hook,SMC_N
k59_160448_1	96561.Dole_0073	1.2e-72	226.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2WJBV@28221|Deltaproteobacteria,2MJ9I@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,CoA_binding,Ligase_CoA
k59_321148_1	1268622.AVS7_03754	7.69e-75	235.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,4AB8M@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_716517_1	1158338.JNLJ01000001_gene1024	4.02e-06	53.9	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel,Big_5,Cadherin,DUF3494,FG-GAP,LVIVD,Laminin_G_3,TIR_2,WD40
k59_61779_1	1244869.H261_13359	2.08e-10	63.9	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,2U3UR@28211|Alphaproteobacteria,2JVEM@204441|Rhodospirillales	204441|Rhodospirillales	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
k59_877944_1	344747.PM8797T_01349	2.89e-18	86.7	COG4191@1|root,COG4191@2|Bacteria,2IXRK@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_877944_2	3983.cassava4.1_030583m	2.27e-10	65.1	COG5641@1|root,KOG1601@2759|Eukaryota,37IG1@33090|Viridiplantae,3GDXD@35493|Streptophyta,4JNRF@91835|fabids	35493|Streptophyta	K	two-component response regulator	-	GO:0000156,GO:0000160,GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006355,GO:0007154,GO:0007165,GO:0007275,GO:0008150,GO:0009653,GO:0009719,GO:0009725,GO:0009735,GO:0009736,GO:0009755,GO:0009888,GO:0009889,GO:0009987,GO:0010015,GO:0010033,GO:0010073,GO:0010075,GO:0010082,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0022622,GO:0023052,GO:0031323,GO:0031326,GO:0032501,GO:0032502,GO:0032870,GO:0035556,GO:0040008,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048364,GO:0048507,GO:0048509,GO:0048638,GO:0048731,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051171,GO:0051239,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071368,GO:0071495,GO:0080090,GO:0099402,GO:0140110,GO:1903506,GO:1905392,GO:2000026,GO:2000112,GO:2000280,GO:2001141	-	ko:K14491	ko04075,map04075	-	-	-	ko00000,ko00001	-	-	-	Myb_DNA-binding,Response_reg
k59_356129_1	1121035.AUCH01000017_gene2243	4.31e-35	125.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,2KV37@206389|Rhodocyclales	206389|Rhodocyclales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_356129_2	187272.Mlg_1558	2.2e-34	126.0	COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,1TKD5@1236|Gammaproteobacteria,1X1ZA@135613|Chromatiales	135613|Chromatiales	C	plastoquinol--plastocyanin reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_617346_1	331869.BAL199_12941	2.24e-153	442.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2VFEC@28211|Alphaproteobacteria,4BQWR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_520248_1	1267534.KB906756_gene225	7.04e-64	214.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	nfdA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_321153_1	870187.Thini_0171	9.04e-38	140.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RZFF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
k59_160452_1	519989.ECTPHS_13218	9.94e-179	537.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_224916_1	1122612.AUBA01000003_gene1495	2.73e-13	71.2	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria,2K1F0@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_224916_2	426355.Mrad2831_1540	2.79e-26	105.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,1JR7Q@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM alanine racemase domain protein	-	-	4.1.3.41	ko:K18425	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
k59_1026749_1	1168059.KB899087_gene2305	1.69e-17	81.3	COG2095@1|root,COG2095@2|Bacteria,1RAFQ@1224|Proteobacteria,2TVJF@28211|Alphaproteobacteria,3EZM5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_61784_2	1121127.JAFA01000002_gene1785	3.4e-22	98.2	COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,2VHXY@28216|Betaproteobacteria,1K0YC@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
k59_683857_1	335543.Sfum_2864	1.78e-45	159.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2MRM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_387439_1	1279017.AQYJ01000026_gene363	3.5e-13	69.3	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,465A1@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_387439_2	349124.Hhal_0582	6.73e-46	155.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1WW3N@135613|Chromatiales	135613|Chromatiales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_356150_1	1384056.N787_06130	8.72e-53	171.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1X41Q@135614|Xanthomonadales	135614|Xanthomonadales	EH	with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_847253_1	436308.Nmar_0399	3.01e-81	246.0	COG0098@1|root,arCOG04087@2157|Archaea,41SFS@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS5 family	-	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_847253_2	1229909.NSED_01925	3.99e-21	87.0	COG0256@1|root,arCOG04088@2157|Archaea,41SQW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
k59_909463_1	269799.Gmet_0936	3.52e-40	135.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,43V75@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	SMART HNH nuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH_5
k59_649670_1	439235.Dalk_1928	1.21e-114	338.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_417063_1	1313301.AUGC01000005_gene211	9.51e-87	273.0	COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes	976|Bacteroidetes	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_417071_1	330214.NIDE0989	8.44e-57	194.0	COG0358@1|root,COG0358@2|Bacteria,3J0IN@40117|Nitrospirae	40117|Nitrospirae	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4,Toprim_N,zf-CHC2
k59_281632_2	1045856.EcWSU1_02655	9.79e-09	58.2	COG2856@1|root,COG2856@2|Bacteria,1NASY@1224|Proteobacteria,1SNHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Macro
k59_716567_1	62928.azo0836	1.32e-94	292.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,2KVV7@206389|Rhodocyclales	206389|Rhodocyclales	J	glutaminyl-tRNA	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_617389_1	330214.NIDE3155	7.45e-39	138.0	COG0725@1|root,COG0725@2|Bacteria	2|Bacteria	P	tungstate binding	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_617389_2	330214.NIDE3156	4.26e-21	92.4	COG1476@1|root,COG1910@1|root,COG1476@2|Bacteria,COG1910@2|Bacteria,3J13A@40117|Nitrospirae	40117|Nitrospirae	K	PBP superfamily domain	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
k59_356177_1	1454004.AW11_02932	1.4e-42	145.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,1KQKF@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	CO	Redoxin	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
k59_356177_2	580332.Slit_1793	1.43e-75	248.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,44VEM@713636|Nitrosomonadales	28216|Betaproteobacteria	O	TIGRFAM cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_1008216_1	1459636.NTE_00725	4.02e-111	320.0	arCOG08699@1|root,arCOG08699@2157|Archaea,41S8N@651137|Thaumarchaeota	1459636.NTE_00725|-	C	PFAM Ammonia monooxygenase methane monooxygenase, subunit C	-	-	-	ko:K10946	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	-
k59_127918_1	8083.ENSXMAP00000000839	4.63e-07	57.8	KOG0288@1|root,KOG0288@2759|Eukaryota,38G4W@33154|Opisthokonta,3B9XJ@33208|Metazoa,3CUU9@33213|Bilateria,481YJ@7711|Chordata,48Y2H@7742|Vertebrata,4A0G5@7898|Actinopterygii	33208|Metazoa	S	ATG16 autophagy related 16-like 1 (S. cerevisiae)	ATG16L1	GO:0000045,GO:0000272,GO:0000421,GO:0001894,GO:0002065,GO:0002067,GO:0002165,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005776,GO:0005829,GO:0005856,GO:0005929,GO:0005930,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0006464,GO:0006497,GO:0006501,GO:0006807,GO:0006914,GO:0006950,GO:0006952,GO:0006996,GO:0007033,GO:0007154,GO:0007275,GO:0007552,GO:0008104,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009251,GO:0009267,GO:0009605,GO:0009607,GO:0009617,GO:0009653,GO:0009791,GO:0009886,GO:0009888,GO:0009894,GO:0009987,GO:0009991,GO:0010506,GO:0010623,GO:0012501,GO:0015980,GO:0016020,GO:0016032,GO:0016043,GO:0016052,GO:0016236,GO:0016740,GO:0018410,GO:0019058,GO:0019079,GO:0019222,GO:0019538,GO:0019787,GO:0019899,GO:0022607,GO:0030154,GO:0030855,GO:0031090,GO:0031323,GO:0031329,GO:0031667,GO:0031668,GO:0031669,GO:0032501,GO:0032502,GO:0032838,GO:0032991,GO:0033036,GO:0033554,GO:0034274,GO:0034497,GO:0034613,GO:0034645,GO:0035069,GO:0035096,GO:0035883,GO:0035973,GO:0036211,GO:0039689,GO:0039694,GO:0042157,GO:0042158,GO:0042592,GO:0042594,GO:0042742,GO:0042802,GO:0042995,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043687,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044275,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044430,GO:0044437,GO:0044441,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0045595,GO:0048468,GO:0048707,GO:0048856,GO:0048869,GO:0048871,GO:0048872,GO:0048873,GO:0050789,GO:0050793,GO:0050794,GO:0050830,GO:0050896,GO:0051020,GO:0051179,GO:0051259,GO:0051260,GO:0051641,GO:0051704,GO:0051707,GO:0051716,GO:0055114,GO:0060033,GO:0060249,GO:0060429,GO:0060786,GO:0061723,GO:0061739,GO:0061912,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0070727,GO:0070925,GO:0071496,GO:0071704,GO:0071840,GO:0097014,GO:0098542,GO:0098588,GO:0098792,GO:0098805,GO:0099568,GO:0120025,GO:0120038,GO:0140096,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494,GO:1905037,GO:1990234	-	ko:K17890	ko04136,ko04138,ko04140,ko04621,map04136,map04138,map04140,map04621	-	-	-	ko00000,ko00001,ko03029,ko04131	-	-	-	ATG16,WD40
k59_1008217_2	525897.Dbac_1642	1.89e-14	76.6	COG0642@1|root,COG2197@1|root,COG2202@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
k59_909491_1	1082933.MEA186_30901	2.78e-58	205.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_253798_1	105559.Nwat_3075	1.8e-31	129.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_914935_1	1064535.MELS_0939	6.74e-107	325.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4H2T2@909932|Negativicutes	909932|Negativicutes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_327242_1	765912.Thimo_0218	6.35e-37	131.0	COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria,1WYHV@135613|Chromatiales	135613|Chromatiales	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_327242_2	292415.Tbd_2610	1.2e-16	80.5	COG0642@1|root,COG2205@2|Bacteria,1QV1H@1224|Proteobacteria,2WGY6@28216|Betaproteobacteria,1KTC9@119069|Hydrogenophilales	119069|Hydrogenophilales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_882147_1	1379698.RBG1_1C00001G1403	1.97e-85	270.0	COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria	2|Bacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
k59_196668_2	1500893.JQNB01000001_gene1770	1.56e-18	83.6	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1T08S@1236|Gammaproteobacteria,1XCZE@135614|Xanthomonadales	135614|Xanthomonadales	S	Eukaryotic integral membrane protein (DUF1751)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_882150_1	29581.BW37_03594	2.95e-36	130.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2VJ8M@28216|Betaproteobacteria,4732H@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
k59_359803_3	1504319.GM45_4445	8.57e-22	95.9	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,3UWTI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_261963_1	1288494.EBAPG3_24750	7.77e-80	247.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2VIQ4@28216|Betaproteobacteria,371Q4@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_686367_1	221288.JH992901_gene4684	4.44e-16	79.7	COG0842@1|root,COG0842@2|Bacteria,1G259@1117|Cyanobacteria,1JK56@1189|Stigonemataceae	1117|Cyanobacteria	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
k59_849577_1	511062.GU3_15850	1.57e-41	154.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1Y6KX@135624|Aeromonadales	135624|Aeromonadales	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_99659_1	1538295.JY96_20985	1.2e-31	119.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
k59_99659_2	270374.MELB17_07999	5.09e-22	92.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,4677Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the CinA family	ygaD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
k59_164982_1	402881.Plav_1795	7.2e-92	279.0	COG2159@1|root,COG2159@2|Bacteria,1PZ2M@1224|Proteobacteria,2VCU0@28211|Alphaproteobacteria,1JQHC@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_916022_1	1122132.AQYH01000008_gene2348	6.01e-86	270.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,4BC9C@82115|Rhizobiaceae	28211|Alphaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_491612_1	1033736.CAHK01000013_gene964	1.75e-37	136.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4F8NS@85019|Brevibacteriaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_262998_1	1283076.M1HLV2_9CAUD	1.17e-36	132.0	4QC5H@10239|Viruses,4QVHT@35237|dsDNA viruses  no RNA stage,4QPNZ@28883|Caudovirales,4QIPU@10662|Myoviridae	10662|Myoviridae	S	sigma factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_262998_2	1283076.M1IPA8_9CAUD	1.91e-28	112.0	4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses  no RNA stage,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae	10662|Myoviridae	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_589438_1	1120983.KB894571_gene2507	2.28e-30	110.0	COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2UC8C@28211|Alphaproteobacteria,1JP8M@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Sarcosine oxidase, delta subunit family	soxD	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
k59_589438_2	1131814.JAFO01000001_gene2996	1.61e-22	96.3	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,3EY9Y@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Sarcosine oxidase beta subunit	soxB	-	1.5.3.1,1.5.99.5	ko:K00303,ko:K22084	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
k59_164991_1	1121346.KB899812_gene2135	1.31e-96	291.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4HCSN@91061|Bacilli,26SYM@186822|Paenibacillaceae	91061|Bacilli	G	Periplasmic substrate-binding component of the ATP-dependent ribose transport system	rbsB3	-	-	ko:K10439,ko:K17202	ko02010,ko02030,map02010,map02030	M00212,M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.16,3.A.1.2.19	-	-	Peripla_BP_4
k59_295510_1	330214.NIDE2917	9.91e-58	182.0	COG4768@1|root,COG4768@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF948)	WQ51_05790	-	-	-	-	-	-	-	-	-	-	-	DUF948
k59_295510_2	330214.NIDE2916	4.82e-08	51.6	COG4980@1|root,COG4980@2|Bacteria,3J1B3@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
k59_393350_1	330214.NIDE2515	9.23e-115	361.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2,DUF3971,DUF748
k59_67128_1	1121033.AUCF01000009_gene1139	5.42e-62	201.0	COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria,2TTT8@28211|Alphaproteobacteria,2JPJ3@204441|Rhodospirillales	204441|Rhodospirillales	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_524138_1	1499967.BAYZ01000148_gene1746	3.01e-106	322.0	COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_687481_1	1304883.KI912532_gene1917	2.27e-80	252.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,2KUUD@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_67129_1	1232452.BAIB02000014_gene2272	6.22e-13	71.6	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia,268B8@186813|unclassified Clostridiales	186801|Clostridia	P	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfT	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
k59_784193_1	497321.C664_13484	9.69e-76	230.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2VR7B@28216|Betaproteobacteria,2KW2Z@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_589451_1	1187851.A33M_4034	1.83e-131	405.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_850439_1	237368.SCABRO_02649	4.38e-68	224.0	COG0778@1|root,COG0778@2|Bacteria,2J1TJ@203682|Planctomycetes	203682|Planctomycetes	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_622102_1	555778.Hneap_0412	2e-72	230.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1RRMU@1236|Gammaproteobacteria,1X26N@135613|Chromatiales	135613|Chromatiales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_524147_1	710687.KI912270_gene4825	9.44e-13	67.0	COG3267@1|root,COG3267@2|Bacteria,2IA4V@201174|Actinobacteria,23874@1762|Mycobacteriaceae	201174|Actinobacteria	U	SMART AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_981056_1	1030157.AFMP01000011_gene3764	1.39e-10	66.6	COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,2TRX7@28211|Alphaproteobacteria,2K174@204457|Sphingomonadales	204457|Sphingomonadales	H	Elongator protein 3, MiaB family, Radical SAM	cofG	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,Radical_SAM
k59_67141_1	1121035.AUCH01000009_gene795	5.54e-138	397.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,2KVBG@206389|Rhodocyclales	206389|Rhodocyclales	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_491644_1	224911.27351247	2.09e-23	98.2	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,2TTSG@28211|Alphaproteobacteria,3JRZP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_850455_1	398767.Glov_3558	1.19e-34	127.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N28@68525|delta/epsilon subdivisions,2WN16@28221|Deltaproteobacteria,43V85@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_850455_2	1120960.ATXG01000011_gene3653	1.66e-07	54.3	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FMKN@85023|Microbacteriaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_99706_1	1198452.Jab_1c15110	1.65e-65	228.0	COG0744@1|root,COG0744@2|Bacteria,1NRPB@1224|Proteobacteria,2VJ7F@28216|Betaproteobacteria,4768K@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_360708_1	1245471.PCA10_20980	9.84e-86	268.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1YDGK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	ygcE	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
k59_165029_1	443144.GM21_0895	2.73e-19	85.1	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2WJX4@28221|Deltaproteobacteria,43TZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_165029_2	330214.NIDE2046	3.36e-70	223.0	COG0133@1|root,COG0133@2|Bacteria,3J0E1@40117|Nitrospirae	40117|Nitrospirae	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_850458_1	945713.IALB_0041	5.11e-64	203.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	mhpC	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
k59_850458_2	997296.PB1_17424	4.92e-12	66.6	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,4HAVA@91061|Bacilli,1ZDBA@1386|Bacillus	91061|Bacilli	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_360709_1	1502852.FG94_00666	4.78e-22	95.9	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,472BY@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_360709_2	1123392.AQWL01000004_gene2542	8.34e-81	243.0	COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,2VQ0U@28216|Betaproteobacteria,1KSI4@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Polypeptide deformylase	-	-	-	-	-	-	-	-	-	-	-	-	Pep_deformylase
k59_165034_1	41431.PCC8801_3019	7.03e-27	112.0	COG0477@1|root,COG2814@2|Bacteria,1G1MW@1117|Cyanobacteria,3KHEM@43988|Cyanothece	1117|Cyanobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k59_458683_1	998088.B565_3819	2.39e-91	283.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1Y44T@135624|Aeromonadales	135624|Aeromonadales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_948510_1	62928.azo2198	6.79e-32	124.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,2KUNN@206389|Rhodocyclales	206389|Rhodocyclales	T	ATPase related to phosphate starvation-inducible protein PhoH	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_948510_2	1266925.JHVX01000009_gene130	5.05e-39	134.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VR4P@28216|Betaproteobacteria,3737P@32003|Nitrosomonadales	28216|Betaproteobacteria	O	PFAM Alkyl hydroperoxide reductase	bcp	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_850469_2	1123393.KB891326_gene104	5.29e-48	155.0	COG2920@1|root,COG2920@2|Bacteria,1N3YM@1224|Proteobacteria,2W3KZ@28216|Betaproteobacteria,1KT8Y@119069|Hydrogenophilales	119069|Hydrogenophilales	P	DsrC like protein	-	-	-	-	-	-	-	-	-	-	-	-	DsrC
k59_850469_3	1276756.AUEX01000015_gene1971	8.5e-13	67.0	2CM31@1|root,32SD0@2|Bacteria,1N2TZ@1224|Proteobacteria,2VUNK@28216|Betaproteobacteria,4ADXP@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_426098_1	1268622.AVS7_03447	1.49e-78	247.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_426098_2	795666.MW7_3090	3.46e-51	174.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6T9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_393398_1	1396858.Q666_14440	2.25e-44	147.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,467RP@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1393 Arsenate reductase and related proteins, glutaredoxin family	arsC	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
k59_883024_1	717774.Marme_3084	1.22e-73	233.0	COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,1XH81@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2333
k59_556974_1	765911.Thivi_1409	4.28e-79	249.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria,1WYW4@135613|Chromatiales	135613|Chromatiales	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_132451_1	322710.Avin_05570	6.18e-54	188.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990	Transket_pyr,Transketolase_C,Transketolase_N
k59_165055_1	886293.Sinac_2790	7.49e-15	70.5	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
k59_165055_2	1415779.JOMH01000001_gene224	2.12e-17	76.3	2E9PU@1|root,333W6@2|Bacteria,1N6VC@1224|Proteobacteria,1SCC9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_3
k59_328247_1	247639.MGP2080_02525	1.49e-91	283.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1233 Phytoene dehydrogenase and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_981097_1	644107.SL1157_1308	1.25e-160	462.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,4NCZP@97050|Ruegeria	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_720086_1	519989.ECTPHS_07267	3.19e-41	150.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales	135613|Chromatiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_720086_2	987059.RBXJA2T_12652	2.18e-31	112.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,1KMB5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_622161_1	105559.Nwat_0349	1.94e-78	258.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales	135613|Chromatiales	U	type IV pilus secretin PilQ	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_230206_1	62928.azo0993	1.4e-113	333.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,2KVQ9@206389|Rhodocyclales	206389|Rhodocyclales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_230206_2	292415.Tbd_2569	1.07e-17	80.9	COG2143@1|root,COG2143@2|Bacteria,1NP6X@1224|Proteobacteria,2WGR9@28216|Betaproteobacteria,1KT3R@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_34531_1	1304888.ATWF01000001_gene800	9.09e-21	94.0	COG1639@1|root,COG1639@2|Bacteria,2GFGS@200930|Deferribacteres	200930|Deferribacteres	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k59_67203_1	640081.Dsui_2814	9e-139	414.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_654921_1	671143.DAMO_0518	9.06e-69	212.0	COG1329@1|root,COG1329@2|Bacteria,2NPWZ@2323|unclassified Bacteria	2|Bacteria	K	CarD-like/TRCF domain	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
k59_458712_1	518766.Rmar_2140	1.54e-50	174.0	COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,4NS7V@976|Bacteroidetes	976|Bacteroidetes	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_948548_1	977880.RALTA_A1499	1.18e-93	280.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,1K1E9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	TIGRFAM hydrolase, TatD family	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_197787_1	1123393.KB891329_gene988	4e-21	90.1	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,1KS6Z@119069|Hydrogenophilales	119069|Hydrogenophilales	I	Squalene/phytoene synthase	-	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
k59_165079_1	1121440.AUMA01000009_gene671	1.63e-67	218.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,2MA1B@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	O-methyltransferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
k59_948551_1	93220.LV28_04380	6.76e-76	249.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,1K1SA@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_360763_1	56780.SYN_02553	4.42e-29	117.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria,2MQWD@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Exodeoxyribonuclease V, gamma subunit	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_360763_2	1121413.JMKT01000012_gene579	3.66e-14	69.7	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,42WCF@68525|delta/epsilon subdivisions,2WRES@28221|Deltaproteobacteria,2MFJ9@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_295608_1	945713.IALB_2293	2.43e-68	221.0	COG2027@1|root,COG2027@2|Bacteria	2|Bacteria	M	serine-type D-Ala-D-Ala carboxypeptidase activity	dacB	GO:0000003,GO:0000270,GO:0000910,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009987,GO:0016043,GO:0016787,GO:0016998,GO:0017171,GO:0019538,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0032505,GO:0033218,GO:0033293,GO:0036094,GO:0042597,GO:0043093,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044464,GO:0045229,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:0140096,GO:1901135,GO:1901136,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901681	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	iAPECO1_1312.APECO1_3250,iECOK1_1307.ECOK1_3603,iECS88_1305.ECS88_3564,iUMN146_1321.UM146_00470,iUTI89_1310.UTI89_C3615,iYL1228.KPN_03592	DUF1460,Peptidase_S13
k59_34551_1	7668.SPU_020023-tr	3.82e-62	208.0	COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa,3D8IP@33213|Bilateria	33208|Metazoa	H	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	Chromo,rve
k59_295610_1	1163617.SCD_n00618	1.59e-138	429.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_566935_2	1116375.VEJY3_13930	0.000204	48.1	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1NBHM@1224|Proteobacteria,1SB7E@1236|Gammaproteobacteria,1XTIQ@135623|Vibrionales	135623|Vibrionales	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,HTH_33
k59_78399_1	1160721.RBI_I01848	5.19e-16	83.6	COG0249@1|root,COG0553@1|root,COG0827@1|root,COG1192@1|root,COG4646@1|root,COG0249@2|Bacteria,COG0553@2|Bacteria,COG0827@2|Bacteria,COG1192@2|Bacteria,COG4646@2|Bacteria,1TPQA@1239|Firmicutes,2491X@186801|Clostridia,3WGBP@541000|Ruminococcaceae	186801|Clostridia	L	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,MutS_I,SNF2_N
k59_829325_1	266264.Rmet_0542	2.58e-83	258.0	COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2VMCZ@28216|Betaproteobacteria,1K6MT@119060|Burkholderiaceae	28216|Betaproteobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
k59_861011_1	448385.sce5514	4.38e-76	240.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	SGL,VCBS
k59_110700_1	420662.Mpe_A2996	5.28e-28	113.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VHN6@28216|Betaproteobacteria,1KMWZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_339018_1	1226994.AMZB01000100_gene1012	1.7e-32	125.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1YFE9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_666039_1	472759.Nhal_0229	1.85e-80	257.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales	135613|Chromatiales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_78414_1	330214.NIDE2489	9.04e-37	134.0	28MEN@1|root,2ZASA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_78414_2	330214.NIDE2490	3.14e-117	338.0	29ZH8@1|root,30MGZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_927181_1	330214.NIDE2728	6.39e-20	82.4	COG0509@1|root,COG0509@2|Bacteria,3J0SD@40117|Nitrospirae	40117|Nitrospirae	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_927181_2	330214.NIDE2730	3.32e-64	198.0	COG0105@1|root,COG0105@2|Bacteria,3J0PH@40117|Nitrospirae	40117|Nitrospirae	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_208337_1	81824.XP_001744815.1	2.46e-06	52.0	COG0501@1|root,KOG2661@2759|Eukaryota	2759|Eukaryota	O	negative regulation of mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_829343_1	760568.Desku_1221	1.05e-22	97.1	COG1085@1|root,COG1085@2|Bacteria,1TS3F@1239|Firmicutes,249P3@186801|Clostridia,2602F@186807|Peptococcaceae	186801|Clostridia	H	Galactose-1-phosphate uridyl transferase, C-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,DUF4931,GalP_UDP_tr_C,GalP_UDP_transf
k59_829343_2	330214.NIDE3904	2.22e-33	125.0	COG0438@1|root,COG0438@2|Bacteria,3J0Z0@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_110711_1	243233.MCA0868	8.2e-63	205.0	COG2334@1|root,COG2334@2|Bacteria,1Q18Y@1224|Proteobacteria,1RR8Y@1236|Gammaproteobacteria,1XEQS@135618|Methylococcales	135618|Methylococcales	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_893254_1	1227484.C471_08745	1.25e-19	90.5	COG1414@1|root,arCOG02798@2157|Archaea,2XWET@28890|Euryarchaeota,23TYS@183963|Halobacteria	183963|Halobacteria	K	COG1414 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_927183_1	1223521.BBJX01000008_gene1330	6.35e-105	313.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria,4AAKA@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_208339_1	1304883.KI912532_gene2022	2.06e-23	97.4	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2VR4C@28216|Betaproteobacteria,2KW6V@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
k59_208339_2	1123393.KB891330_gene776	6.45e-62	200.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,1KSUT@119069|Hydrogenophilales	119069|Hydrogenophilales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_467423_2	1198452.Jab_2c22440	4.09e-48	165.0	COG1999@1|root,COG1999@2|Bacteria,1MZAW@1224|Proteobacteria	1224|Proteobacteria	S	SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_467423_3	395493.BegalDRAFT_2308	7.07e-10	60.5	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,462TP@72273|Thiotrichales	72273|Thiotrichales	C	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
k59_632790_1	1229909.NSED_07585	2.42e-62	213.0	arCOG08705@1|root,arCOG08705@2157|Archaea,41SXV@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_305634_1	1496688.ER33_04445	4.12e-90	280.0	COG1171@1|root,COG1171@2|Bacteria,1G22X@1117|Cyanobacteria,22SGF@167375|Cyanobium	1117|Cyanobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.ilvA	PALP,Thr_dehydrat_C
k59_305634_2	999541.bgla_2g28310	1.79e-24	102.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,1K3VG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_78423_1	72664.XP_006402344.1	3.81e-13	73.2	COG0625@1|root,KOG0867@2759|Eukaryota,37N5S@33090|Viridiplantae,3GDH8@35493|Streptophyta,3HT9G@3699|Brassicales	35493|Streptophyta	O	Belongs to the GST superfamily	-	GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009635,GO:0009636,GO:0009987,GO:0016740,GO:0016765,GO:0019748,GO:0032991,GO:0034641,GO:0042221,GO:0042802,GO:0042803,GO:0043603,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046983,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901564	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
k59_143415_1	330214.NIDE0413	2.43e-45	152.0	2DQ3Q@1|root,334KX@2|Bacteria	2|Bacteria	S	Proto-chlorophyllide reductase 57 kd subunit	bchB	-	-	-	-	-	-	-	-	-	-	-	PCP_red
k59_143415_2	330214.NIDE0412	1.49e-72	225.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
k59_927211_1	1223521.BBJX01000002_gene2865	3.39e-57	192.0	COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2VKFW@28216|Betaproteobacteria,4AH9U@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
k59_893286_2	1207063.P24_03840	7.77e-84	257.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria,2JQRM@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	dctP	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
k59_829380_1	761193.Runsl_1869	2.98e-48	169.0	28IVH@1|root,2Z8TX@2|Bacteria,4NEEW@976|Bacteroidetes,47N52@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
k59_436592_1	1408473.JHXO01000005_gene1588	5.27e-114	348.0	COG0339@1|root,COG0339@2|Bacteria,4NFYA@976|Bacteroidetes,2FRU7@200643|Bacteroidia	976|Bacteroidetes	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_787721_1	717785.HYPMC_1228	2.62e-30	113.0	2E6JI@1|root,3316K@2|Bacteria,1PP48@1224|Proteobacteria,2UT9Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_45389_1	1280953.HOC_19316	2.25e-50	162.0	COG3293@1|root,COG3293@2|Bacteria,1MYPD@1224|Proteobacteria,2UBMY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_959793_1	926550.CLDAP_29200	1.91e-16	82.8	COG1647@1|root,COG1647@2|Bacteria	2|Bacteria	M	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
k59_13067_1	426114.THI_0322	1.09e-20	90.9	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2VKBD@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NADH dehydrogenase	hyfD	-	-	-	-	-	-	-	-	-	-	-	NADHdh
k59_13067_2	395494.Galf_2382	3.06e-43	147.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2VJTI@28216|Betaproteobacteria,44W5S@713636|Nitrosomonadales	28216|Betaproteobacteria	C	hydrogenase 4 membrane	hyfE	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_666095_1	588932.JHOF01000018_gene1156	1.36e-11	70.1	COG4805@1|root,COG4805@2|Bacteria,1NRZP@1224|Proteobacteria,2UNXX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_502870_1	1502851.FG93_02461	3.37e-81	244.0	COG3335@1|root,COG3335@2|Bacteria,1RB1C@1224|Proteobacteria,2U367@28211|Alphaproteobacteria,3K1KH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_632829_1	1121035.AUCH01000001_gene1851	4.36e-07	51.2	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KVNE@206389|Rhodocyclales	206389|Rhodocyclales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_632829_2	1410653.JHVC01000003_gene4074	1.27e-42	152.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,36EB1@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_787723_1	1286171.EAL2_808p06640	7.85e-29	114.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,25UZ3@186806|Eubacteriaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_10,POR_N,TPP_enzyme_C
k59_787723_2	1125863.JAFN01000001_gene3102	4.17e-35	129.0	COG0183@1|root,COG0183@2|Bacteria,1MXYM@1224|Proteobacteria,42PAF@68525|delta/epsilon subdivisions,2WM45@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
k59_991605_1	452637.Oter_0693	2.55e-77	242.0	COG0019@1|root,COG0019@2|Bacteria,46WJD@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM Orn DAP Arg decarboxylase 2	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_600466_1	1185652.USDA257_c27310	4.93e-81	255.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2U2MU@28211|Alphaproteobacteria,4B7PR@82115|Rhizobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_208397_1	1415756.JQMY01000001_gene896	1.92e-19	87.4	COG1653@1|root,COG1653@2|Bacteria,1MV8A@1224|Proteobacteria,2TTPV@28211|Alphaproteobacteria,2PCWV@252301|Oceanicola	28211|Alphaproteobacteria	G	COG1653 ABC-type sugar transport system, periplasmic component	MA20_44770	-	-	ko:K17321	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	SBP_bac_1,SBP_bac_8
k59_208397_2	859653.HIMB5_00009340	8.86e-57	187.0	COG3839@1|root,COG3839@2|Bacteria,1MX8G@1224|Proteobacteria,2TSXF@28211|Alphaproteobacteria,4BP6W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC transporter	glpS	-	-	ko:K17324	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	ABC_tran,TOBE_2
k59_13084_1	1041159.AZUW01000007_gene5304	2.71e-17	83.2	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,4B8CP@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_13084_2	365044.Pnap_2302	4.59e-29	110.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria,4ABCH@80864|Comamonadaceae	28216|Betaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_239004_1	330214.NIDE4057	2.57e-32	119.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cytochrome_CBB3
k59_698911_1	526222.Desal_2576	4.99e-10	66.2	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43BN0@68525|delta/epsilon subdivisions,2X702@28221|Deltaproteobacteria,2M8FC@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_339102_1	301.JNHE01000003_gene1809	1.08e-09	61.6	COG2165@1|root,COG2165@2|Bacteria,1PSYJ@1224|Proteobacteria,1TBK5@1236|Gammaproteobacteria,1YHZ3@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	NU	Type II transport protein GspH	-	-	-	-	-	-	-	-	-	-	-	-	GspH,N_methyl
k59_110788_1	338969.Rfer_2335	9.57e-96	292.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria,4AD4J@80864|Comamonadaceae	28216|Betaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_568054_1	330214.NIDE1020	1.01e-63	214.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,3J0DN@40117|Nitrospirae	40117|Nitrospirae	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_568054_2	330214.NIDE1019	6.45e-66	213.0	COG0758@1|root,COG0758@2|Bacteria,3J0Q8@40117|Nitrospirae	40117|Nitrospirae	L	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
k59_402287_1	292415.Tbd_0871	7.46e-98	296.0	COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,2W1RG@28216|Betaproteobacteria,1KS0P@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_78498_1	1096930.L284_22405	1.01e-71	226.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,2TW55@28211|Alphaproteobacteria,2KAFH@204457|Sphingomonadales	204457|Sphingomonadales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_78498_2	1122917.KB899665_gene3972	4.18e-89	276.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,4HASY@91061|Bacilli,26W35@186822|Paenibacillaceae	91061|Bacilli	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_632857_1	1249627.D779_2027	5.58e-53	174.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1WWVC@135613|Chromatiales	135613|Chromatiales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_78502_1	1144312.PMI09_04588	4.32e-65	212.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2TTUB@28211|Alphaproteobacteria,4BACX@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
k59_861125_1	1403948.Q618_VCMC00001G0283	4.86e-13	70.1	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4D4VU@85005|Actinomycetales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_861125_2	298655.KI912266_gene2925	3.65e-05	48.1	COG4177@1|root,COG4177@2|Bacteria	2|Bacteria	E	L-phenylalanine transmembrane transporter activity	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_632872_1	1049564.TevJSym_aa01890	5.3e-99	303.0	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_991650_1	1125863.JAFN01000001_gene3103	3.93e-94	291.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
k59_143509_1	261292.Nit79A3_1577	1.33e-173	501.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,2VUMQ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_666165_1	1118153.MOY_14397	9.8e-48	170.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,1RMEB@1236|Gammaproteobacteria,1XNW9@135619|Oceanospirillales	135619|Oceanospirillales	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	-	-	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
k59_731359_1	1095769.CAHF01000011_gene2096	2.22e-46	160.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,473C5@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	PPIC-type PPIASE domain	cbf2	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N_3
k59_731359_2	1454004.AW11_00312	5.62e-28	103.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2VVNP@28216|Betaproteobacteria,1KQ5G@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	Belongs to the BolA IbaG family	bolA	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
k59_731359_3	323848.Nmul_A2112	3.08e-16	72.4	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2VUM7@28216|Betaproteobacteria,373AT@32003|Nitrosomonadales	28216|Betaproteobacteria	S	YCII-related domain	yciI	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_239050_1	1385512.N784_12715	9e-28	108.0	COG0723@1|root,COG0723@2|Bacteria,1TQUH@1239|Firmicutes,4HBX1@91061|Bacilli,2YAA3@289201|Pontibacillus	91061|Bacilli	C	Menaquinol-cytochrome c reductase	qcrA	-	-	ko:K03886	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	CytB6-F_Fe-S,Rieske
k59_761302_1	1429916.X566_10960	2.36e-57	200.0	COG2114@1|root,COG3850@1|root,COG2114@2|Bacteria,COG3850@2|Bacteria,1QW6N@1224|Proteobacteria,2TWQ3@28211|Alphaproteobacteria,3JU8D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,GAF_2,Guanylate_cyc,HAMP,dCache_1
k59_143510_1	243233.MCA2707	9.47e-61	202.0	COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,1RMVT@1236|Gammaproteobacteria,1XDQW@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	-	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_143510_2	481448.Minf_0846	2.76e-15	77.4	COG0224@1|root,COG0224@2|Bacteria,46Y59@74201|Verrucomicrobia,37GHH@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	ATP synthase	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_78536_1	1163617.SCD_n01550	1.62e-96	300.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_371395_1	489825.LYNGBM3L_67960	4.63e-85	281.0	COG1566@1|root,COG2351@1|root,COG3409@1|root,COG1566@2|Bacteria,COG2351@2|Bacteria,COG3409@2|Bacteria,1G4CU@1117|Cyanobacteria,1H7ZW@1150|Oscillatoriales	1117|Cyanobacteria	M	Salmonella virulence plasmid 28.1kDa A protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,VRP1
k59_502940_2	1182590.BN5_01458	2.55e-19	89.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1YDQN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	E1-E2 ATPase	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_239057_1	685727.REQ_06880	2.81e-76	241.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4G086@85025|Nocardiaceae	201174|Actinobacteria	C	Cytochrome P450	cyp142A3	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652	1.14.13.221	ko:K16046	ko00984,ko01120,map00984,map01120	-	R09859,R11361	RC01216,RC03368	ko00000,ko00001,ko00199,ko01000	-	-	-	p450
k59_991672_2	404589.Anae109_0401	4.42e-46	150.0	COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,43765@68525|delta/epsilon subdivisions,2X24N@28221|Deltaproteobacteria,2YW4N@29|Myxococcales	28221|Deltaproteobacteria	H	pterin-4-alpha-carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_305739_1	556269.ACDQ01000002_gene1083	1.36e-104	334.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,4731N@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_176146_1	479434.Sthe_3412	4.12e-101	310.0	COG1032@1|root,COG1032@2|Bacteria,2G6ZI@200795|Chloroflexi	200795|Chloroflexi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_447088_1	713586.KB900536_gene2920	2.53e-78	240.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1WWK4@135613|Chromatiales	135613|Chromatiales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_349894_1	1122247.C731_1466	9.44e-05	45.1	COG0183@1|root,COG0183@2|Bacteria,2I8JE@201174|Actinobacteria,2374H@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_476612_1	1095769.CAHF01000005_gene1469	1.37e-112	344.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria	28216|Betaproteobacteria	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_742597_1	330214.NIDE3960	1.13e-39	142.0	COG1611@1|root,COG1611@2|Bacteria,3J169@40117|Nitrospirae	40117|Nitrospirae	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_742597_2	330214.NIDE3961	4.8e-20	87.8	COG2404@1|root,COG2404@2|Bacteria,3J12M@40117|Nitrospirae	40117|Nitrospirae	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_89587_2	1000565.METUNv1_02205	2.24e-30	120.0	COG0493@1|root,COG0493@2|Bacteria,1P58U@1224|Proteobacteria,2VKBP@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	Pyr_redox_2
k59_770768_1	429009.Adeg_2162	9.82e-26	98.6	COG2002@1|root,COG2002@2|Bacteria,1W0E3@1239|Firmicutes,25369@186801|Clostridia	186801|Clostridia	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
k59_381641_1	671143.DAMO_3069	1.99e-81	254.0	COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47,2.3.1.50	ko:K00639,ko:K00652,ko:K00654	ko00260,ko00600,ko00780,ko01100,ko04071,ko04138,map00260,map00600,map00780,map01100,map04071,map04138	M00094,M00099,M00123,M00573,M00577	R00371,R01281,R03210,R10124	RC00004,RC00039,RC00394,RC02725,RC02849	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_447109_1	1346791.M529_05415	4.44e-21	97.4	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2UNZR@28211|Alphaproteobacteria,2KECI@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_278264_1	1238182.C882_3908	1.29e-47	171.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,2JP85@204441|Rhodospirillales	204441|Rhodospirillales	MU	CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin)	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_579245_2	1297570.MESS4_370007	1.96e-23	99.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRQX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_971113_2	411464.DESPIG_01692	8.46e-28	114.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2M80Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_792087_2	1121405.dsmv_2939	8.15e-49	166.0	COG2214@1|root,COG2214@2|Bacteria,1NW19@1224|Proteobacteria,43012@68525|delta/epsilon subdivisions,2WVBG@28221|Deltaproteobacteria,2MNIU@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_55788_1	1040983.AXAE01000015_gene1370	1.37e-06	49.3	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSTD@28211|Alphaproteobacteria,43I92@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_55788_2	935548.KI912159_gene3532	1.15e-52	176.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2TUGD@28211|Alphaproteobacteria,43GW8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_677428_2	316058.RPB_1738	1.02e-60	199.0	COG0683@1|root,COG0683@2|Bacteria,1MV1Z@1224|Proteobacteria,2TRTD@28211|Alphaproteobacteria,3JRR8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_476631_1	7029.ACYPI065480-PA	0.000492	47.8	2E6PU@1|root,2SDCQ@2759|Eukaryota,3ABW1@33154|Opisthokonta,3BVKN@33208|Metazoa,3DJX5@33213|Bilateria,4239J@6656|Arthropoda	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_476631_2	7739.XP_002590018.1	4.03e-19	85.1	2D0S2@1|root,2SF6P@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_349937_1	180281.CPCC7001_1827	2.79e-41	145.0	COG3187@1|root,COG3187@2|Bacteria,1GMTF@1117|Cyanobacteria,22TW4@167375|Cyanobium	1117|Cyanobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
k59_840790_1	985665.HPL003_24715	2.54e-06	54.7	COG1234@1|root,COG1234@2|Bacteria,1UYM3@1239|Firmicutes,4HEWE@91061|Bacilli,26U57@186822|Paenibacillaceae	91061|Bacilli	S	beta-lactamase	rnaZ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
k59_349942_1	94624.Bpet0628	5.98e-71	221.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,3T1RP@506|Alcaligenaceae	28216|Betaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_349942_2	365046.Rta_34780	3e-25	103.0	COG3181@1|root,COG3181@2|Bacteria,1P88K@1224|Proteobacteria,2VJJP@28216|Betaproteobacteria,4AJD9@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_55810_1	76114.ebA2060	3.85e-80	254.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,2KV3E@206389|Rhodocyclales	28216|Betaproteobacteria	I	Methylmalonyl-CoA mutase	icmF	-	5.4.99.2,5.4.99.63,5.4.99.64	ko:K01847,ko:K01848,ko:K14447,ko:K20906	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833,R09292	RC00395,RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_938483_1	945713.IALB_0503	2.82e-78	243.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_579292_1	1121405.dsmv_3248	2.12e-63	201.0	28PNF@1|root,2ZCB7@2|Bacteria,1RA6N@1224|Proteobacteria,42RBI@68525|delta/epsilon subdivisions,2WN4P@28221|Deltaproteobacteria,2MJHU@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_219053_1	290397.Adeh_3063	5.03e-19	92.0	COG5295@1|root,COG5295@2|Bacteria,1QVUF@1224|Proteobacteria	1224|Proteobacteria	UW	this gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin
k59_770818_2	388051.AUFE01000035_gene3961	9.09e-23	100.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,1K1ZS@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_219057_1	1408473.JHXO01000011_gene2991	1.23e-80	267.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes	976|Bacteroidetes	T	PFAM BNR Asp-box repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_840821_2	1121405.dsmv_3597	4.89e-42	145.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42RJU@68525|delta/epsilon subdivisions,2WNBX@28221|Deltaproteobacteria,2MJTX@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_248400_1	1000565.METUNv1_03634	5.74e-36	133.0	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,2KWIW@206389|Rhodocyclales	206389|Rhodocyclales	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
k59_154475_1	762903.Pedsa_0137	9.64e-78	245.0	COG0849@1|root,COG0849@2|Bacteria,4NE0V@976|Bacteroidetes,1IQJQ@117747|Sphingobacteriia	976|Bacteroidetes	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_643676_1	436308.Nmar_0255	1.68e-05	43.9	COG1581@1|root,arCOG01753@2157|Archaea,41SQ4@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
k59_643676_2	436308.Nmar_0256	6.68e-87	262.0	COG2513@1|root,arCOG00581@2157|Archaea,41SEN@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_770829_1	1485544.JQKP01000023_gene864	1.82e-155	471.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,44W4X@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_513978_1	1278073.MYSTI_04368	2.81e-66	213.0	COG4122@1|root,COG4122@2|Bacteria,1R9D7@1224|Proteobacteria,42ZQ8@68525|delta/epsilon subdivisions,2WVSH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
k59_611343_2	640081.Dsui_0889	1.92e-26	107.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,2KUC9@206389|Rhodocyclales	206389|Rhodocyclales	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_535859_1	1122963.AUHB01000013_gene4675	3.17e-08	54.3	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria,370CR@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_535859_2	98439.AJLL01000107_gene4300	7.42e-90	279.0	COG3842@1|root,COG3842@2|Bacteria,1G10Y@1117|Cyanobacteria,1JHS3@1189|Stigonemataceae	1117|Cyanobacteria	E	TOBE domain	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
k59_219074_1	267608.RSc0466	3.38e-40	146.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1K0F2@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_219074_2	1157637.KB892156_gene3959	7.81e-33	117.0	COG4290@1|root,COG4290@2|Bacteria,2IHPV@201174|Actinobacteria	201174|Actinobacteria	F	Ribonuclease	-	-	3.1.27.3	ko:K01167	-	-	-	-	ko00000,ko01000,ko03016,ko03019	-	-	-	Ribonuclease
k59_349990_1	926569.ANT_26670	1.8e-65	214.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi	200795|Chloroflexi	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_513982_1	1163617.SCD_n01348	5.8e-73	236.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VHWW@28216|Betaproteobacteria	28216|Betaproteobacteria	C	eight transmembrane protein EpsH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
k59_872028_1	945713.IALB_1183	5.27e-60	209.0	COG3387@1|root,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
k59_770838_1	1117647.M5M_12365	3.55e-09	58.2	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1J4FR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein containing LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_770838_2	1266925.JHVX01000007_gene2278	1.26e-100	306.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,372M0@32003|Nitrosomonadales	28216|Betaproteobacteria	LU	DNA recombination-mediator protein A	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_611353_1	1121447.JONL01000001_gene404	1.52e-55	184.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2M93E@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_611354_1	2340.JV46_12010	3.3e-69	217.0	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,1RN6Q@1236|Gammaproteobacteria,1J5TX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
k59_611354_2	713586.KB900536_gene2646	6.76e-11	61.6	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_381732_1	519989.ECTPHS_02501	3.3e-20	88.6	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1WW9X@135613|Chromatiales	135613|Chromatiales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_381732_2	1177179.A11A3_02932	3.18e-37	136.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1XIS6@135619|Oceanospirillales	135619|Oceanospirillales	M	Lytic murein transglycosylase B	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_278319_1	926560.KE387023_gene3595	2.89e-62	217.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,1WMBC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,TPR_12
k59_89694_2	945713.IALB_1466	1.66e-26	98.2	2BVK8@1|root,32Y0S@2|Bacteria	2|Bacteria	S	histone H1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hc1
k59_643707_1	604331.AUHY01000029_gene1019	8.9e-98	302.0	COG1274@1|root,COG1274@2|Bacteria,1WM9E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_248427_1	743720.Psefu_3509	1.37e-73	232.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,1RNCH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_316379_2	1144307.PMI04_01236	5.97e-21	89.0	COG1028@1|root,COG1028@2|Bacteria,1RDD5@1224|Proteobacteria,2U9RJ@28211|Alphaproteobacteria,2K3CW@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_792463_1	1384056.N787_06740	2.43e-06	54.3	COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,1RRK7@1236|Gammaproteobacteria,1X4CC@135614|Xanthomonadales	135614|Xanthomonadales	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_580215_1	1120953.AUBH01000014_gene2525	1.82e-59	196.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria	1224|Proteobacteria	I	Acyl-transferase	-	GO:0000271,GO:0005575,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_412489_1	666685.R2APBS1_1785	2.67e-22	90.9	COG1278@1|root,COG1278@2|Bacteria,1N1M6@1224|Proteobacteria,1S9AQ@1236|Gammaproteobacteria,1X8B4@135614|Xanthomonadales	135614|Xanthomonadales	K	Excalibur calcium-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Excalibur
k59_412489_2	296591.Bpro_2372	1.03e-46	156.0	COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2VK5E@28216|Betaproteobacteria,4AAXC@80864|Comamonadaceae	28216|Betaproteobacteria	C	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
k59_743576_2	713586.KB900536_gene533	2.67e-49	170.0	COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
k59_904443_1	62928.azo1296	9.04e-87	268.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,2KUU8@206389|Rhodocyclales	206389|Rhodocyclales	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_350857_1	722419.PH505_ab00720	6.58e-14	71.2	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,2PZVR@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089	Glyco_tran_28_C,Glyco_transf_28
k59_24976_1	1499967.BAYZ01000103_gene3733	3.9e-87	273.0	COG0008@1|root,COG0008@2|Bacteria,2NNRW@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
k59_514856_1	1120999.JONM01000004_gene3641	2.64e-35	136.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,2KQ56@206351|Neisseriales	206351|Neisseriales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_612175_1	713586.KB900536_gene532	4.76e-81	250.0	COG2367@1|root,COG2367@2|Bacteria,1R6KF@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_711211_1	907931.AEIZ01000002_gene625	1.1e-11	61.6	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,4HRGW@91061|Bacilli,4AY3F@81850|Leuconostocaceae	91061|Bacilli	KT	Transcriptional regulator	pspC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
k59_972068_1	323848.Nmul_A1700	4.16e-88	274.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2VPE5@28216|Betaproteobacteria,372J2@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Saccharopine dehydrogenase C-terminal domain	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_644561_1	1265502.KB905956_gene162	4.93e-106	324.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,4ACB9@80864|Comamonadaceae	28216|Betaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_155366_1	436308.Nmar_1389	2.21e-101	299.0	COG0543@1|root,arCOG02199@2157|Archaea,41SY5@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
k59_711218_1	330214.NIDE3701	1.73e-113	334.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_781924_1	653733.Selin_2559	3.75e-09	56.6	COG0376@1|root,COG0376@2|Bacteria	2|Bacteria	P	catalase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_781924_2	1313301.AUGC01000011_gene1122	3.49e-34	123.0	COG0735@1|root,COG0735@2|Bacteria,4NT7Y@976|Bacteroidetes	976|Bacteroidetes	P	Belongs to the Fur family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_781924_3	945713.IALB_1697	2.88e-34	127.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_422756_1	1120956.JHZK01000057_gene1843	3.85e-47	155.0	COG2963@1|root,COG2963@2|Bacteria,1N75X@1224|Proteobacteria,2UIVT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28
k59_422756_2	1120956.JHZK01000057_gene1844	1.56e-21	92.4	COG2801@1|root,COG2801@2|Bacteria,1R471@1224|Proteobacteria,2U60M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_259153_1	1124991.MU9_2864	1.72e-08	57.4	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,1S3TR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_259153_2	1038860.AXAP01000017_gene2908	1.91e-48	163.0	COG0329@1|root,COG0329@2|Bacteria,1MWAH@1224|Proteobacteria,2TSXX@28211|Alphaproteobacteria,3JX92@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EM	Dihydrodipicolinate synthetase family	dapAch4	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_487225_1	485913.Krac_4231	4.67e-76	245.0	COG0129@1|root,COG0129@2|Bacteria,2G5QW@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_422767_1	640081.Dsui_1974	1.31e-36	135.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,2KW8Q@206389|Rhodocyclales	206389|Rhodocyclales	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_543519_1	1142394.PSMK_01460	8.24e-10	65.5	COG0767@1|root,COG0767@2|Bacteria,2IX01@203682|Planctomycetes	203682|Planctomycetes	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_487250_1	1163617.SCD_n02948	7.14e-49	167.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_487258_1	1430440.MGMSRv2_0479	7.18e-49	164.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2U09K@28211|Alphaproteobacteria,2JRQ8@204441|Rhodospirillales	204441|Rhodospirillales	O	Proteasome-type protease	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
k59_487258_2	1500894.JQNN01000001_gene1588	6.62e-23	98.6	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,472PB@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_796800_1	1454004.AW11_01618	9.38e-83	260.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,1KPVG@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_796800_2	1005048.CFU_1345	4.88e-44	150.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,473C9@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_259190_1	244581.IM40_04555	2.58e-53	188.0	COG2860@1|root,COG2860@2|Bacteria,1QVY0@1224|Proteobacteria,2UB1W@28211|Alphaproteobacteria,47F2R@766|Rickettsiales	766|Rickettsiales	S	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3,UPF0126
k59_259198_1	1223521.BBJX01000007_gene1577	5.29e-101	323.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,4A9MX@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_487301_1	485917.Phep_3651	6.74e-64	209.0	COG0477@1|root,COG2814@2|Bacteria,4PKJD@976|Bacteroidetes,1IPFN@117747|Sphingobacteriia	976|Bacteroidetes	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_H_symport
k59_422842_1	1003200.AXXA_01110	2.84e-55	192.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VM2H@28216|Betaproteobacteria,3T57X@506|Alcaligenaceae	28216|Betaproteobacteria	L	Superfamily I DNA and RNA helicases	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_543603_1	216142.LT40_04955	1.22e-11	61.2	COG2900@1|root,COG2900@2|Bacteria,1NGFM@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the SlyX family	slyX	-	-	ko:K03745	-	-	-	-	ko00000	-	-	-	SlyX
k59_543603_2	393595.ABO_1115	8.32e-22	94.4	COG0697@1|root,COG0697@2|Bacteria,1R7CG@1224|Proteobacteria,1S0XU@1236|Gammaproteobacteria,1XJ96@135619|Oceanospirillales	135619|Oceanospirillales	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_422863_1	1191523.MROS_0568	5.61e-97	286.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
k59_259245_1	926569.ANT_31640	1.13e-79	243.0	COG1573@1|root,COG1573@2|Bacteria,2G6BR@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_782042_1	1268239.PALB_28370	6.9e-22	99.4	COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,1RQEQ@1236|Gammaproteobacteria,2Q0I6@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_422871_1	926569.ANT_10570	2.47e-74	244.0	COG1185@1|root,COG1185@2|Bacteria,2G5TS@200795|Chloroflexi	200795|Chloroflexi	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_284831_1	595460.RRSWK_04821	3.85e-39	147.0	COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_543669_1	935836.JAEL01000010_gene3736	1.64e-64	209.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,4H9MS@91061|Bacilli,1ZC8R@1386|Bacillus	91061|Bacilli	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
k59_487462_1	94624.Bpet1714	1.22e-41	149.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2VHP9@28216|Betaproteobacteria,3T1SF@506|Alcaligenaceae	28216|Betaproteobacteria	E	branched-chain amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_543736_1	1288494.EBAPG3_27420	6.65e-45	153.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,371UX@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Exodeoxyribonuclease III xth	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_543736_2	240016.ABIZ01000001_gene5118	0.0002	45.1	COG0785@1|root,COG2319@1|root,COG0785@2|Bacteria,COG2319@2|Bacteria,46YMF@74201|Verrucomicrobia,2IV1J@203494|Verrucomicrobiae	2|Bacteria	O	Wd-40 repeat	mauF	-	2.7.11.1	ko:K03466,ko:K06196,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko02000,ko03036	3.A.12,5.A.1.2	-	-	AAA_16,Trans_reg_C,WD40
k59_782144_1	748247.AZKH_0137	1.45e-85	268.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,2KUPW@206389|Rhodocyclales	206389|Rhodocyclales	DM	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_796901_1	1380394.JADL01000001_gene2766	9.59e-72	221.0	COG0500@1|root,COG2226@2|Bacteria,1QSZ6@1224|Proteobacteria,2U0WV@28211|Alphaproteobacteria,2JUVE@204441|Rhodospirillales	204441|Rhodospirillales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_259419_1	640081.Dsui_1101	1.99e-127	380.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,2KVCK@206389|Rhodocyclales	206389|Rhodocyclales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_259419_2	395961.Cyan7425_1873	1.32e-20	92.0	COG3608@1|root,COG3608@2|Bacteria,1G38S@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
k59_487559_2	289376.THEYE_A1195	6.76e-64	207.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
k59_487573_1	345341.KUTG_10190	6.02e-26	116.0	COG5421@1|root,COG5421@2|Bacteria,2IEYR@201174|Actinobacteria	201174|Actinobacteria	L	Domain of unknown function (DUF4277)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4277
k59_259450_1	509190.Cseg_2050	3.15e-51	183.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,2TSUV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_423111_1	926569.ANT_04930	9.07e-23	96.3	COG0083@1|root,COG0083@2|Bacteria,2G6MP@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_423111_2	330779.Saci_2233	9.75e-06	46.6	COG0183@1|root,arCOG01279@2157|Archaea,2XQ2B@28889|Crenarchaeota	28889|Crenarchaeota	I	acetyl-CoA C-acyltransferase activity	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
k59_550693_1	234267.Acid_0041	6.2e-08	55.8	COG4122@1|root,COG4122@2|Bacteria,3Y33U@57723|Acidobacteria	57723|Acidobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_550693_2	323848.Nmul_A0510	9.93e-148	431.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VZIT@28216|Betaproteobacteria,371QJ@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Trypsin	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_803819_1	1131553.JIBI01000008_gene1321	7.81e-11	62.4	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,371XM@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1035343_1	768706.Desor_1650	2.92e-82	250.0	COG1410@1|root,COG1410@2|Bacteria,1V0F4@1239|Firmicutes,25CEI@186801|Clostridia,260JU@186807|Peptococcaceae	186801|Clostridia	E	PFAM Pterin binding enzyme	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_291522_1	1410618.JNKI01000016_gene1820	4.12e-24	103.0	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,4H2B2@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_1035455_1	76114.ebA5811	4.28e-21	93.6	COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,2VR6Y@28216|Betaproteobacteria,2KXI6@206389|Rhodocyclales	206389|Rhodocyclales	M	OmpW family	ompW	-	-	ko:K07275	-	-	-	-	ko00000	-	-	-	OmpW
k59_804021_1	395019.Bmul_1225	1.13e-158	458.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,1K4T4@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the malate synthase family	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_291646_1	671143.DAMO_1591	1.76e-53	176.0	COG2386@1|root,COG2386@2|Bacteria,2NPSF@2323|unclassified Bacteria	2|Bacteria	O	CcmB protein	ccmB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193,ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	iECO111_1330.ECO111_2936,iYL1228.KPN_02080	CcmB
k59_550984_1	1379698.RBG1_1C00001G1724	1.26e-08	57.8	COG0845@1|root,COG0845@2|Bacteria,2NR7K@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mdtA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_804052_1	743720.Psefu_1355	1.34e-82	260.0	COG4670@1|root,COG4670@2|Bacteria,1MX9F@1224|Proteobacteria,1RMW2@1236|Gammaproteobacteria,1YVYY@136845|Pseudomonas putida group	1236|Gammaproteobacteria	I	malonate decarboxylase, alpha subunit	mdcA	-	2.3.1.187	ko:K13929	-	-	R08944	RC00012,RC00014	ko00000,ko01000,ko02000	3.B.1.1.4	-	-	Mal_decarbox_Al
k59_1035531_1	640511.BC1002_6941	1.99e-26	107.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VME6@28216|Betaproteobacteria,1K3H4@119060|Burkholderiaceae	28216|Betaproteobacteria	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_804087_2	257310.BB3364	5.78e-54	180.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,3T2W6@506|Alcaligenaceae	28216|Betaproteobacteria	I	Belongs to the thiolase family	bktB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_551063_1	28229.ND2E_4151	3.24e-43	150.0	COG3193@1|root,COG3193@2|Bacteria,1R215@1224|Proteobacteria,1S4R1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_291762_1	1123401.JHYQ01000022_gene1146	1.23e-73	241.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,461P1@72273|Thiotrichales	72273|Thiotrichales	F	5'-nucleotidase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
k59_804167_1	983917.RGE_34140	3.36e-100	294.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria,1KK8S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulator, Crp Fnr family	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_291795_1	416591.Tlet_1950	3.68e-62	204.0	COG0205@1|root,COG0205@2|Bacteria,2GC8H@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_551137_1	330214.NIDE1157	4.32e-101	306.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1035632_1	941449.dsx2_0875	2.8e-35	136.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,2M8UV@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_804211_1	1207075.PputUW4_01734	2.3e-66	210.0	COG2095@1|root,COG2095@2|Bacteria,1RAFQ@1224|Proteobacteria,1S2XM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_804213_1	522306.CAP2UW1_0567	4.87e-20	88.2	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,1KQG6@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_804213_2	640081.Dsui_0234	2.11e-29	113.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,2KW1D@206389|Rhodocyclales	206389|Rhodocyclales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_1035650_1	1229205.BUPH_04252	2.02e-87	288.0	COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,1K40G@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD linked oxidase domain protein	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_804250_1	1157708.KB907462_gene1030	5.6e-60	203.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2VTNQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_40349_3	1232410.KI421413_gene633	2.48e-95	280.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,42QWQ@68525|delta/epsilon subdivisions,2WMRI@28221|Deltaproteobacteria,43T93@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_268925_1	1120999.JONM01000002_gene751	1.54e-11	63.5	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2VHDR@28216|Betaproteobacteria,2KPHX@206351|Neisseriales	206351|Neisseriales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_268925_2	557598.LHK_00461	1.09e-36	124.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,2VTZ4@28216|Betaproteobacteria,2KRK8@206351|Neisseriales	206351|Neisseriales	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
k59_268925_3	266264.Rmet_2608	3.41e-07	49.7	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,1K70P@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_726130_1	543632.JOJL01000054_gene205	1.18e-88	270.0	COG0395@1|root,COG0395@2|Bacteria,2GNQW@201174|Actinobacteria,4DH96@85008|Micromonosporales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
k59_661003_1	748247.AZKH_3144	3.7e-79	243.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,2KUN1@206389|Rhodocyclales	206389|Rhodocyclales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_595442_1	330214.NIDE1304	7.67e-70	236.0	COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_922142_1	864051.BurJ1DRAFT_4158	1.12e-72	228.0	COG3303@1|root,COG3303@2|Bacteria,1NEPE@1224|Proteobacteria,2VVS8@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_73326_1	498211.CJA_2939	5.42e-43	153.0	COG0784@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2200@2|Bacteria,1NC9X@1224|Proteobacteria,1T1M2@1236|Gammaproteobacteria,1FGNX@10|Cellvibrio	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	vieA	-	3.1.4.52	ko:K13246	ko05111,map05111	-	R08991	RC00296	ko00000,ko00001,ko01000	-	-	-	EAL,GerE,Response_reg
k59_73326_2	644801.Psest_0653	3.06e-21	91.3	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,1Z0GA@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB2	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
k59_693663_1	338963.Pcar_3128	1.35e-28	111.0	COG1082@1|root,COG1082@2|Bacteria,1N8KJ@1224|Proteobacteria,42SR1@68525|delta/epsilon subdivisions,2WP5P@28221|Deltaproteobacteria,43U6X@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_661016_1	1244869.H261_01197	4.48e-92	276.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria,2JQRS@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1024 Enoyl-CoA hydratase carnithine racemase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_366540_1	5911.EAR92515	0.000249	48.9	2E06Q@1|root,2S7N4@2759|Eukaryota,3ZC3V@5878|Ciliophora	5878|Ciliophora	S	S1/P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
k59_73337_1	324057.Pjdr2_0523	2.12e-07	57.8	COG2303@1|root,COG2303@2|Bacteria,1TSGS@1239|Firmicutes,4HE6B@91061|Bacilli,26XXV@186822|Paenibacillaceae	91061|Bacilli	E	GMC oxidoreductase	-	-	1.1.99.3	ko:K06151	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3
k59_888576_1	1131553.JIBI01000002_gene1793	1.82e-112	329.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,372B3@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Transporter associated domain	corC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_398111_1	330214.NIDE2545	2.56e-85	278.0	COG0458@1|root,COG0458@2|Bacteria,3J0BC@40117|Nitrospirae	40117|Nitrospirae	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_138464_1	332101.JIBU02000048_gene3741	6.57e-09	64.7	COG1073@1|root,COG1073@2|Bacteria,1TRSD@1239|Firmicutes,25DV1@186801|Clostridia,36HCG@31979|Clostridiaceae	186801|Clostridia	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100
k59_986764_1	330214.NIDE3392	7.12e-87	276.0	COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_171055_1	887062.HGR_13039	0.000113	44.3	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,4AC49@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_171055_2	987059.RBXJA2T_13509	6.02e-30	115.0	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,2VJDD@28216|Betaproteobacteria,1KPIP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	membrane protein, terc	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_335091_2	583345.Mmol_0157	1.03e-62	196.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,2KMU8@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_335091_3	1131553.JIBI01000046_gene1594	1.36e-15	74.7	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VU93@28216|Betaproteobacteria,3732S@32003|Nitrosomonadales	28216|Betaproteobacteria	CO	Thioredoxin-like	tlpA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_661983_1	360910.BAV2417	2.5e-63	202.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,3T3CT@506|Alcaligenaceae	28216|Betaproteobacteria	I	synthase	hpnC	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_171983_1	330214.NIDE3365	3.77e-64	215.0	COG0683@1|root,COG0683@2|Bacteria,3J18U@40117|Nitrospirae	40117|Nitrospirae	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_563954_1	261292.Nit79A3_2037	1.38e-103	328.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,371WK@32003|Nitrosomonadales	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_41315_1	864051.BurJ1DRAFT_3753	6.82e-91	291.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1KJS6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_596406_1	296591.Bpro_4103	2.18e-43	152.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2VM00@28216|Betaproteobacteria,4ABHF@80864|Comamonadaceae	28216|Betaproteobacteria	S	Ankyrin repeats (3 copies)	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4
k59_727163_1	671143.DAMO_0559	0.000607	41.2	COG0201@1|root,COG0201@2|Bacteria,2NNVK@2323|unclassified Bacteria	2|Bacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_727163_2	1121428.DESHY_110116___1	6.87e-62	196.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,260CT@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
k59_41317_1	1392490.JHZX01000001_gene2007	2.52e-38	147.0	COG3604@1|root,COG3829@1|root,COG3604@2|Bacteria,COG3829@2|Bacteria,4PM5Y@976|Bacteroidetes,1IK4D@117743|Flavobacteriia	976|Bacteroidetes	KT	Sigma-54 interaction domain	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Response_reg,Sigma54_activat,cNMP_binding
k59_301947_1	522306.CAP2UW1_1513	2.45e-58	187.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,2VT65@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_825255_1	1453501.JELR01000001_gene2878	1.48e-28	120.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,4640D@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345	SBP_bac_3,SLT
k59_41326_1	425104.Ssed_0198	1.08e-60	202.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,2Q8ZR@267890|Shewanellaceae	1236|Gammaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_727176_1	929556.Solca_1315	1.44e-60	198.0	COG0150@1|root,COG0150@2|Bacteria,4NE4E@976|Bacteroidetes,1IQ5E@117747|Sphingobacteriia	976|Bacteroidetes	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_955646_1	335283.Neut_1556	1.08e-94	289.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,371PY@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_694716_1	864051.BurJ1DRAFT_1327	1.71e-13	68.9	2CKKR@1|root,332MC@2|Bacteria,1NCAT@1224|Proteobacteria,2VW6M@28216|Betaproteobacteria,1KMMV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_563987_1	265072.Mfla_0090	2.33e-22	96.7	2DKZI@1|root,310D6@2|Bacteria,1QV1U@1224|Proteobacteria,2VQ0G@28216|Betaproteobacteria,2KP95@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_563987_2	1043205.AFYF01000087_gene1181	2.86e-43	156.0	COG0277@1|root,COG0277@2|Bacteria,2GJ33@201174|Actinobacteria,4FFAM@85021|Intrasporangiaceae	201174|Actinobacteria	C	D-arabinono-1,4-lactone oxidase	-	-	-	-	-	-	-	-	-	-	-	-	ALO,FAD_binding_4
k59_757936_1	1238182.C882_3508	1.76e-95	287.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,2JQDG@204441|Rhodospirillales	204441|Rhodospirillales	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_301971_1	485915.Dret_1322	2.83e-68	224.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2M7RB@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_563991_1	557598.LHK_00623	9.94e-22	89.7	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,2KQYT@206351|Neisseriales	206351|Neisseriales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_563991_2	748247.AZKH_1265	3.29e-54	172.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,2VUVV@28216|Betaproteobacteria,2KWJI@206389|Rhodocyclales	206389|Rhodocyclales	H	dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
k59_204501_1	196162.Noca_1181	3.83e-28	110.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4DN7C@85009|Propionibacteriales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_204501_2	196162.Noca_1180	2.22e-21	90.9	COG4177@1|root,COG4177@2|Bacteria	2|Bacteria	E	L-phenylalanine transmembrane transporter activity	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_269919_1	522306.CAP2UW1_3348	3.8e-63	212.0	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,2VKRX@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Male sterility	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
k59_955652_1	436308.Nmar_1778	7.37e-29	110.0	arCOG08685@1|root,arCOG08685@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_955652_2	436308.Nmar_1777	3.07e-109	319.0	COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota	651137|Thaumarchaeota	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_41356_1	323848.Nmul_A0259	3.91e-55	186.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,2WFJ1@28216|Betaproteobacteria,3723B@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
k59_204514_1	345073.VC395_0340	2.4e-08	53.9	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1XWV0@135623|Vibrionales	135623|Vibrionales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_204514_2	1131553.JIBI01000010_gene1378	5.66e-64	199.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,3738V@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_923220_2	1120999.JONM01000008_gene2075	1.25e-57	194.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,2KQ75@206351|Neisseriales	206351|Neisseriales	S	RmuC domain protein	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_367570_1	1227739.Hsw_0691	8.87e-53	190.0	COG2373@1|root,COG2373@2|Bacteria,4NEW9@976|Bacteroidetes,47MDC@768503|Cytophagia	976|Bacteroidetes	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,MG1,Thiol-ester_cl
k59_74363_1	118173.KB235914_gene1016	2.97e-22	92.0	COG0745@1|root,COG0745@2|Bacteria,1G8I2@1117|Cyanobacteria,1HCIH@1150|Oscillatoriales	1117|Cyanobacteria	KT	PFAM Signal transduction response regulator, receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_74363_2	472175.EL18_01257	1.13e-33	129.0	COG2199@1|root,COG3437@1|root,COG3437@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,43IGX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
k59_825303_1	1266925.JHVX01000008_gene368	3.63e-160	466.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,371S5@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_889477_1	335283.Neut_0400	8.09e-157	454.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,372RZ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_106808_1	1172188.KB911821_gene2076	5.9e-28	112.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,2GNPX@201174|Actinobacteria,4FFVN@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	osaB	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_955674_1	436308.Nmar_0214	3.65e-109	327.0	COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_41374_1	880072.Desac_1622	1.62e-115	338.0	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,42N7B@68525|delta/epsilon subdivisions,2WJYE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type beta subunit	dsrB	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr
k59_564016_1	1379698.RBG1_1C00001G0065	2.47e-16	77.8	COG1331@1|root,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
k59_564016_2	945713.IALB_0513	4.32e-83	252.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_367585_1	864051.BurJ1DRAFT_3558	3.59e-32	128.0	COG1506@1|root,COG1506@2|Bacteria,1R968@1224|Proteobacteria,2WHWP@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
k59_41387_1	1242864.D187_007127	2.8e-67	223.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,42P4Q@68525|delta/epsilon subdivisions,2WK5G@28221|Deltaproteobacteria,2YU4N@29|Myxococcales	28221|Deltaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_857314_1	383407.XOC_3576	7.15e-11	68.9	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1S30T@1236|Gammaproteobacteria,1X53B@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c
k59_204540_1	338966.Ppro_1205	1.98e-21	91.3	COG0006@1|root,COG0006@2|Bacteria,1RAMF@1224|Proteobacteria	1224|Proteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_204540_2	1123502.AQXD01000003_gene1439	2.55e-44	156.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1X32D@135614|Xanthomonadales	135614|Xanthomonadales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_172066_1	1288494.EBAPG3_4510	1.07e-20	91.3	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,372JX@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_172066_2	204773.HEAR1795	1.21e-50	164.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2VT12@28216|Betaproteobacteria,47411@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_74388_1	330214.NIDE3058	3.95e-96	296.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
k59_857321_1	85643.Tmz1t_3406	3.13e-68	218.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2VHJF@28216|Betaproteobacteria,2KVHN@206389|Rhodocyclales	206389|Rhodocyclales	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_857321_2	519989.ECTPHS_05521	7.67e-18	81.6	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1WWQ8@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_694778_1	1280948.HY36_12890	7.5e-11	69.3	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,43WK1@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_302023_1	436308.Nmar_0947	2.58e-59	187.0	COG2131@1|root,arCOG01487@2157|Archaea,41SHS@651137|Thaumarchaeota	651137|Thaumarchaeota	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
k59_302023_2	1229909.NSED_05405	9.34e-39	144.0	COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA polymerase	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
k59_343953_1	118168.MC7420_8114	1.73e-32	129.0	COG2274@1|root,COG2274@2|Bacteria,1G0V8@1117|Cyanobacteria,1H80U@1150|Oscillatoriales	1117|Cyanobacteria	V	Type I secretion system ABC transporter, HlyB family	hlyB	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39,cNMP_binding
k59_213157_1	472175.EL18_02048	7.53e-88	275.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,43HE3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_637628_1	1121035.AUCH01000008_gene1026	7.07e-39	139.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,2KUKQ@206389|Rhodocyclales	206389|Rhodocyclales	S	protein containing LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_637628_2	1000565.METUNv1_03062	1.59e-12	64.3	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria,2KW47@206389|Rhodocyclales	206389|Rhodocyclales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_50144_1	1288494.EBAPG3_25720	2.22e-80	241.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VR4P@28216|Betaproteobacteria,3737P@32003|Nitrosomonadales	28216|Betaproteobacteria	O	PFAM Alkyl hydroperoxide reductase	bcp	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_180861_2	330214.NIDE3226	2.66e-17	82.8	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_406383_1	519989.ECTPHS_05435	2.66e-97	296.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_573036_1	1229909.NSED_02215	4.15e-27	103.0	COG0102@1|root,arCOG04242@2157|Archaea,41SP4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_573036_2	1229909.NSED_02210	1.89e-86	256.0	COG0088@1|root,arCOG04243@2157|Archaea,41SKT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS9 family	-	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_376057_1	748247.AZKH_0447	5.29e-119	366.0	COG0074@1|root,COG0074@2|Bacteria,1R4KP@1224|Proteobacteria,2W14T@28216|Betaproteobacteria,2KYIY@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Succ_CoA_lig
k59_376057_2	196367.JNFG01000011_gene6107	8.13e-69	220.0	COG0045@1|root,COG0045@2|Bacteria,1PYM0@1224|Proteobacteria,2W8VT@28216|Betaproteobacteria,1K6TP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	ATP citrate lyase citrate-binding	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_2,Citrate_bind
k59_243120_1	1163398.AJJP01000090_gene3646	1.8e-13	68.9	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I	yycJ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_243120_2	1198452.Jab_2c06070	1.87e-16	80.9	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,473P9@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_964873_1	1121946.AUAX01000021_gene8087	1.53e-35	132.0	COG3618@1|root,COG3618@2|Bacteria,2IB8W@201174|Actinobacteria,4DJ63@85008|Micromonosporales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_765424_1	935548.KI912159_gene4082	2.04e-147	422.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRW0@28211|Alphaproteobacteria,43IFQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type alpha subunit	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_18014_1	1163617.SCD_n02500	1.2e-69	228.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,2VSUT@28216|Betaproteobacteria	28216|Betaproteobacteria	M	LppC putative lipoprotein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_50173_1	7668.SPU_010933-tr	1.36e-31	127.0	KOG1075@1|root,KOG2233@1|root,KOG1075@2759|Eukaryota,KOG2233@2759|Eukaryota,38C0N@33154|Opisthokonta	33154|Opisthokonta	U	alpha-N-acetylglucosaminidase activity	NAGLU	GO:0000323,GO:0003674,GO:0003824,GO:0004553,GO:0004561,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0005775,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0007275,GO:0007399,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0015929,GO:0016787,GO:0016798,GO:0030203,GO:0031974,GO:0031982,GO:0032501,GO:0032502,GO:0043170,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043230,GO:0043231,GO:0043233,GO:0044421,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0048731,GO:0048856,GO:0070013,GO:0070062,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903561	3.2.1.50	ko:K01205	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078	R07816	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	NAGLU,NAGLU_C,NAGLU_N
k59_932267_1	977880.RALTA_A2338	3.21e-80	248.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,1K0U6@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_932267_2	365046.Rta_15220	7.03e-06	47.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2VIU0@28216|Betaproteobacteria,4AA7Q@80864|Comamonadaceae	28216|Betaproteobacteria	H	riboflavin synthase, alpha	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_736413_1	1121396.KB892913_gene116	2.87e-48	168.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42WI2@68525|delta/epsilon subdivisions,2WRPD@28221|Deltaproteobacteria,2MQ18@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_897840_1	639283.Snov_2530	2.34e-189	536.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,3F146@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_50182_1	305700.B447_01111	9.13e-71	237.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,2KV41@206389|Rhodocyclales	206389|Rhodocyclales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_637665_1	1342299.Z947_120	3.83e-170	495.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_18028_1	1123288.SOV_3c05900	4.25e-49	172.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,4H2PX@909932|Negativicutes	909932|Negativicutes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_115707_1	690850.Desaf_1409	8.45e-29	108.0	COG1139@1|root,COG1139@2|Bacteria,1RIJX@1224|Proteobacteria,42PGB@68525|delta/epsilon subdivisions,2WK1F@28221|Deltaproteobacteria,2MB7J@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
k59_115707_2	1121405.dsmv_0668	1.17e-23	95.9	COG0589@1|root,COG0589@2|Bacteria,1MZ7T@1224|Proteobacteria,42U3S@68525|delta/epsilon subdivisions,2WQ9F@28221|Deltaproteobacteria,2MKFQ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_996443_1	652103.Rpdx1_2547	3.57e-27	107.0	COG4886@1|root,COG4886@2|Bacteria,1R6KE@1224|Proteobacteria,2U57E@28211|Alphaproteobacteria,3JXZD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_996443_2	1141136.K4F5X3_9CAUD	1.04e-118	364.0	4QC5J@10239|Viruses,4QXP7@35237|dsDNA viruses  no RNA stage,4QTBX@28883|Caudovirales,4QJQT@10662|Myoviridae	10662|Myoviridae	S	Domain of unknown function (DUF2828)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_471555_1	436308.Nmar_0341	7.4e-21	90.1	COG1104@1|root,arCOG00066@2157|Archaea,41SB1@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_471555_2	436308.Nmar_0340	1.27e-48	163.0	COG1606@1|root,arCOG00043@2157|Archaea,41SF3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	tRNA methyl transferase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	QueC
k59_704064_2	1382306.JNIM01000001_gene3968	0.000664	43.5	COG0681@1|root,COG0681@2|Bacteria,2G701@200795|Chloroflexi	200795|Chloroflexi	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
k59_148446_1	436308.Nmar_1794	1.86e-130	401.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
k59_1020616_1	945713.IALB_2995	5.23e-66	226.0	COG4288@1|root,COG4288@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,Big_5,CHU_C,FlgD_ig,LTD
k59_406443_1	765420.OSCT_1798	8.72e-40	150.0	COG0443@1|root,COG0443@2|Bacteria,2GBRB@200795|Chloroflexi,3768Q@32061|Chloroflexia	32061|Chloroflexia	O	Hsp70 protein	-	-	-	ko:K04046	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_736443_1	640081.Dsui_1091	1.61e-62	202.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,2KW1Z@206389|Rhodocyclales	206389|Rhodocyclales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_243168_1	1509405.GV67_09955	2.79e-08	56.2	COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2TS8Y@28211|Alphaproteobacteria,4B8GW@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ABC-type proline glycine betaine transport system, ATPase component	proV	GO:0000166,GO:0003674,GO:0004888,GO:0005034,GO:0005215,GO:0005275,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0016020,GO:0016021,GO:0017076,GO:0022857,GO:0023052,GO:0030554,GO:0031224,GO:0031460,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0038023,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060089,GO:0065007,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran
k59_243168_2	391165.GbCGDNIH1_0085	1.9e-64	204.0	COG4176@1|root,COG4176@2|Bacteria,1QTTE@1224|Proteobacteria,2TS3U@28211|Alphaproteobacteria,2JPG7@204441|Rhodospirillales	204441|Rhodospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_573114_1	720554.Clocl_2673	9.89e-30	121.0	COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,249ZV@186801|Clostridia,3WGT5@541000|Ruminococcaceae	186801|Clostridia	L	Mu transposase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_50212_1	518766.Rmar_2595	4.01e-112	332.0	COG0409@1|root,COG0409@2|Bacteria,4NIM8@976|Bacteroidetes	976|Bacteroidetes	O	TIGRFAM hydrogenase expression formation protein HypD	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_310197_1	768670.Calni_0859	1.08e-47	173.0	COG1520@1|root,COG3391@1|root,COG4249@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,Peptidase_C14,WD40
k59_115744_2	330214.NIDE0343	2.37e-21	92.8	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_964944_1	936455.KI421499_gene478	2.62e-46	160.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2TT62@28211|Alphaproteobacteria,3JSQG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Fatty acid desaturase	aco1	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_507839_1	439235.Dalk_5060	7.7e-124	358.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,2MJAK@213118|Desulfobacterales	28221|Deltaproteobacteria	CH	Oxidoreductase FAD-binding domain	hdrF	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
k59_441402_1	580332.Slit_2713	1.46e-67	216.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,44VGJ@713636|Nitrosomonadales	28216|Betaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_671233_1	1100721.ALKO01000003_gene2055	3.36e-172	489.0	COG0683@1|root,COG0683@2|Bacteria,1MV3Y@1224|Proteobacteria,2VJRG@28216|Betaproteobacteria,4AAG7@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular liganD-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_704094_1	261292.Nit79A3_3457	9.46e-94	284.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,372PH@32003|Nitrosomonadales	28216|Betaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_148480_2	1217720.ALOX01000027_gene3658	4.81e-53	176.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,2JS3U@204441|Rhodospirillales	204441|Rhodospirillales	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_932329_1	2340.JV46_03690	1.23e-86	269.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_3206	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_866098_2	1163617.SCD_n02453	1.78e-30	114.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_671245_1	69042.WH5701_09920	4.6e-154	441.0	COG3335@1|root,COG3335@2|Bacteria,1G60T@1117|Cyanobacteria,1H3RV@1129|Synechococcus	1117|Cyanobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
k59_115764_1	573.JG24_27235	4.34e-54	186.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF2	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_344061_2	383372.Rcas_0677	3.18e-13	68.9	COG1051@1|root,COG1051@2|Bacteria,2G9EQ@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_704104_1	404589.Anae109_3410	2.15e-37	138.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,437Y3@68525|delta/epsilon subdivisions,2X380@28221|Deltaproteobacteria,2YURY@29|Myxococcales	28221|Deltaproteobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_18102_1	1229205.BUPH_01941	2.28e-64	219.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,1K20S@119060|Burkholderiaceae	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_637736_1	1121405.dsmv_0518	1.64e-05	52.8	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,2MIGM@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM lipopolysaccharide heptosyltransferase II	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_406486_2	396588.Tgr7_0873	4.23e-19	86.3	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,1T1KM@1236|Gammaproteobacteria,1WXUD@135613|Chromatiales	135613|Chromatiales	G	6-phosphogluconate dehydrogenase	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_789609_2	40571.JOEA01000012_gene1120	4.34e-54	182.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4E1IN@85010|Pseudonocardiales	201174|Actinobacteria	S	hydrolase or acyltransferase of alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
k59_789609_3	946362.XP_004988939.1	1.22e-54	183.0	COG0302@1|root,KOG2698@2759|Eukaryota,38CYY@33154|Opisthokonta	33154|Opisthokonta	H	7,8-dihydroneopterin 3'-triphosphate biosynthetic process	GCH1	GO:0000166,GO:0000278,GO:0001505,GO:0001882,GO:0001883,GO:0002027,GO:0002164,GO:0002165,GO:0002168,GO:0002237,GO:0002376,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0003924,GO:0003933,GO:0003934,GO:0005488,GO:0005509,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006520,GO:0006570,GO:0006575,GO:0006582,GO:0006584,GO:0006585,GO:0006725,GO:0006728,GO:0006729,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0006809,GO:0006950,GO:0006952,GO:0006955,GO:0007049,GO:0007275,GO:0007389,GO:0007591,GO:0008015,GO:0008016,GO:0008150,GO:0008152,GO:0008217,GO:0008270,GO:0008363,GO:0009058,GO:0009072,GO:0009108,GO:0009110,GO:0009396,GO:0009605,GO:0009607,GO:0009617,GO:0009712,GO:0009713,GO:0009790,GO:0009791,GO:0009880,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010460,GO:0010632,GO:0012505,GO:0014916,GO:0016020,GO:0016043,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0017144,GO:0018130,GO:0018958,GO:0019001,GO:0019222,GO:0019238,GO:0019438,GO:0019748,GO:0019751,GO:0019752,GO:0019889,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0030234,GO:0030334,GO:0030742,GO:0031090,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031369,GO:0031410,GO:0031965,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0031982,GO:0032496,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032768,GO:0032770,GO:0032879,GO:0032991,GO:0033301,GO:0033555,GO:0033993,GO:0034097,GO:0034311,GO:0034312,GO:0034341,GO:0034612,GO:0034641,GO:0035150,GO:0035185,GO:0035296,GO:0035639,GO:0036094,GO:0040003,GO:0040012,GO:0042133,GO:0042136,GO:0042221,GO:0042303,GO:0042311,GO:0042335,GO:0042337,GO:0042364,GO:0042398,GO:0042416,GO:0042417,GO:0042423,GO:0042438,GO:0042440,GO:0042558,GO:0042559,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043085,GO:0043095,GO:0043167,GO:0043168,GO:0043169,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043473,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0043933,GO:0044057,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044306,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044550,GO:0045087,GO:0045428,GO:0045429,GO:0045448,GO:0045776,GO:0045823,GO:0046146,GO:0046148,GO:0046165,GO:0046173,GO:0046189,GO:0046209,GO:0046394,GO:0046483,GO:0046655,GO:0046656,GO:0046872,GO:0046914,GO:0046983,GO:0048037,GO:0048066,GO:0048067,GO:0048069,GO:0048072,GO:0048265,GO:0048518,GO:0048522,GO:0048583,GO:0048856,GO:0050662,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050877,GO:0050880,GO:0050884,GO:0050896,GO:0050905,GO:0050999,GO:0051000,GO:0051019,GO:0051066,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051240,GO:0051259,GO:0051260,GO:0051270,GO:0051291,GO:0051336,GO:0051341,GO:0051353,GO:0051704,GO:0051707,GO:0051716,GO:0060308,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071310,GO:0071396,GO:0071704,GO:0071840,GO:0072593,GO:0080134,GO:0080135,GO:0090066,GO:0090322,GO:0097159,GO:0097164,GO:0097367,GO:0097458,GO:0097708,GO:0097746,GO:0097755,GO:0098772,GO:0120025,GO:0120038,GO:1900407,GO:1901031,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901615,GO:1901617,GO:1901700,GO:1901701,GO:1902882,GO:1903409,GO:1903426,GO:1903428,GO:1903522,GO:1903524,GO:1904407,GO:1905627,GO:2000026,GO:2000121,GO:2000145,GO:2000274,GO:2000377,GO:2000379,GO:2001057	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iMM904.YGR267C,iND750.YGR267C	GTP_cyclohydroI
k59_471611_1	76114.ebA3691	7.97e-68	214.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,2KUVG@206389|Rhodocyclales	206389|Rhodocyclales	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_897932_1	945713.IALB_1331	1.66e-13	70.9	COG0468@1|root,COG0468@2|Bacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_344083_1	1120966.AUBU01000006_gene3235	1.47e-41	163.0	2DPN8@1|root,332RD@2|Bacteria,4NX8C@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_180987_2	502025.Hoch_3886	1.07e-46	159.0	COG0278@1|root,COG0316@1|root,COG0607@1|root,COG0278@2|Bacteria,COG0316@2|Bacteria,COG0607@2|Bacteria,1MZ4V@1224|Proteobacteria,43154@68525|delta/epsilon subdivisions,2WWCI@28221|Deltaproteobacteria,2YVCT@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin,Rhodanese
k59_180987_3	1280946.HY29_15085	2.39e-25	102.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TQUY@28211|Alphaproteobacteria,440PV@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_765519_1	1242864.D187_003409	3.15e-64	224.0	COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,1MU6G@1224|Proteobacteria	1224|Proteobacteria	IQ	COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
k59_736505_2	472759.Nhal_3176	1.29e-85	254.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1WYBM@135613|Chromatiales	135613|Chromatiales	S	PFAM Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_376173_1	177439.DP1531	5.54e-31	125.0	COG0745@1|root,COG4963@1|root,COG0745@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,2MJQA@213118|Desulfobacterales	28221|Deltaproteobacteria	D	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA,Response_reg
k59_834648_1	1121127.JAFA01000017_gene6275	1.41e-100	306.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,1K0H7@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Amidase, hydantoinase carbamoylase family	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_441452_1	318996.AXAZ01000001_gene4884	4.37e-62	201.0	COG4663@1|root,COG4663@2|Bacteria,1R40U@1224|Proteobacteria,2U3KB@28211|Alphaproteobacteria,3K34G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_441452_2	318996.AXAZ01000001_gene4883	8.49e-15	71.2	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2UBPX@28211|Alphaproteobacteria,3K2R5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_148520_1	298653.Franean1_5899	3.22e-44	155.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4ERZQ@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133,5.1.3.13	ko:K00067,ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777,R06514	RC00182,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_213299_1	244581.IM40_02690	1.22e-35	130.0	COG3039@1|root,COG3039@2|Bacteria,1Q79J@1224|Proteobacteria,2VDE7@28211|Alphaproteobacteria,47G3F@766|Rickettsiales	766|Rickettsiales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_637759_1	671143.DAMO_2254	1.23e-67	218.0	COG0484@1|root,COG0484@2|Bacteria,2NNNG@2323|unclassified Bacteria	2|Bacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_376178_1	330214.NIDE4397	7.69e-78	243.0	COG0124@1|root,COG0124@2|Bacteria,3J0EC@40117|Nitrospirae	40117|Nitrospirae	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_964997_1	69279.BG36_07155	2.8e-14	79.3	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria,43J5K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1021118_1	697282.Mettu_3888	1.05e-105	313.0	COG0673@1|root,COG0673@2|Bacteria,1MU8F@1224|Proteobacteria,1RNKY@1236|Gammaproteobacteria,1XEQ9@135618|Methylococcales	135618|Methylococcales	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_279497_1	1238182.C882_2973	6.24e-22	93.2	COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,2JRUQ@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N_3
k59_279497_2	1121422.AUMW01000003_gene924	8.78e-19	84.3	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,260XY@186807|Peptococcaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_516246_1	338969.Rfer_4094	9.49e-12	63.5	COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,2VUNU@28216|Betaproteobacteria,4AFUE@80864|Comamonadaceae	28216|Betaproteobacteria	C	[NiFe]-hydrogenase assembly, chaperone, HybE	hoxT	-	-	-	-	-	-	-	-	-	-	-	NiFe-hyd_HybE,Rubredoxin
k59_516246_2	1123256.KB907925_gene1311	3.66e-29	105.0	COG1773@1|root,COG1773@2|Bacteria,1N6TQ@1224|Proteobacteria,1SC8U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
k59_516246_3	269482.Bcep1808_5937	1.97e-09	57.8	COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2VKNQ@28216|Betaproteobacteria,1K5MW@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM HupH hydrogenase expression protein	hoxQ	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
k59_744982_2	90814.KL370891_gene747	1.01e-34	123.0	2BZMS@1|root,32Z9B@2|Bacteria,1NCFD@1224|Proteobacteria,1SPFN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
k59_449311_1	198628.Dda3937_03716	1.14e-57	198.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,2JD3E@204037|Dickeya	1236|Gammaproteobacteria	L	SMART helicase c2	yoaA	GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k59_645882_1	945713.IALB_0353	4.68e-73	227.0	COG0101@1|root,COG0101@2|Bacteria	2|Bacteria	J	tRNA pseudouridine synthase activity	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_874153_1	396588.Tgr7_2494	1.05e-76	243.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_123934_1	443152.MDG893_13624	9.02e-12	64.7	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQMI@1236|Gammaproteobacteria,464EE@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Type II secretory pathway, component PulF	mshG	-	-	ko:K02505,ko:K12278	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_156676_1	765911.Thivi_1724	4.33e-114	343.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPN9@1236|Gammaproteobacteria,1WWMD@135613|Chromatiales	135613|Chromatiales	S	of ABC transporters with duplicated ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_250399_1	1038862.KB893856_gene853	1.41e-80	252.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2U192@28211|Alphaproteobacteria,3JUI7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_1024730_1	1027273.GZ77_12675	1.75e-47	174.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1XHZK@135619|Oceanospirillales	135619|Oceanospirillales	U	Type II and III secretion system protein	pilQ	-	-	ko:K02507,ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_772965_1	247634.GPB2148_1903	2.28e-70	233.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1J5AG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_449335_1	1163617.SCD_n02863	5.57e-34	133.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K02021,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_123951_1	1173028.ANKO01000221_gene586	4.18e-07	51.2	COG1139@1|root,COG1139@2|Bacteria,1GC4K@1117|Cyanobacteria,1HF15@1150|Oscillatoriales	1117|Cyanobacteria	C	Pfam:DUF162	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_8,LUD_dom
k59_123951_2	1173028.ANKO01000221_gene587	5.39e-125	361.0	COG0247@1|root,COG0247@2|Bacteria,1GCV7@1117|Cyanobacteria,1HFVC@1150|Oscillatoriales	1117|Cyanobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_537015_1	323848.Nmul_A2069	1.19e-66	218.0	COG0539@1|root,COG1093@1|root,COG0539@2|Bacteria,COG1093@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,372RZ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_537015_2	522306.CAP2UW1_2900	9.65e-39	144.0	COG0128@1|root,COG0283@1|root,COG0128@2|Bacteria,COG0283@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,1KQIJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
k59_478663_1	1231391.AMZF01000040_gene503	1.83e-18	85.9	COG0683@1|root,COG0683@2|Bacteria,1MV3Y@1224|Proteobacteria,2VJRG@28216|Betaproteobacteria,3T6QN@506|Alcaligenaceae	28216|Betaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_478663_2	1173027.Mic7113_3864	1.59e-07	52.8	COG0179@1|root,COG0179@2|Bacteria,1G06Y@1117|Cyanobacteria,1H915@1150|Oscillatoriales	1117|Cyanobacteria	Q	COGs COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway)	hpcE	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_91969_1	1454004.AW11_01660	2.24e-56	181.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,2VQ8C@28216|Betaproteobacteria	28216|Betaproteobacteria	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC	-	1.2.1.58,1.2.7.1	ko:K00172,ko:K18357	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_91969_2	1123487.KB892840_gene75	8.25e-20	87.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria,2KVEF@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate:ferredoxin oxidoreductase core domain II	padG	-	1.2.1.58	ko:K18355	ko00360,map00360	-	R02450	RC00004,RC02860	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
k59_613557_1	323848.Nmul_A2415	7.88e-95	291.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,37276@32003|Nitrosomonadales	28216|Betaproteobacteria	L	modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1024738_1	436308.Nmar_1182	8.29e-118	348.0	COG0513@1|root,arCOG00558@2157|Archaea,41SM1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
k59_940807_2	378806.STAUR_2549	1.27e-17	91.7	COG1061@1|root,COG1061@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2WJWA@28221|Deltaproteobacteria,2YYR0@29|Myxococcales	28221|Deltaproteobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2,ResIII
k59_581677_1	987059.RBXJA2T_07673	1.19e-128	377.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,1KJ6W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_973489_1	1123392.AQWL01000002_gene1766	7.56e-82	258.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,1KSV4@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome D1 heme domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_26365_1	94624.Bpet2085	2.98e-43	153.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,3T1JW@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_26365_2	1469245.JFBG01000057_gene2374	5.13e-49	167.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1WW0A@135613|Chromatiales	1236|Gammaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1024740_1	84588.SYNW0985	2.58e-68	234.0	COG2931@1|root,COG3209@1|root,COG3898@1|root,COG5625@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3898@2|Bacteria,COG5625@2|Bacteria,1GJ0A@1117|Cyanobacteria,1H18T@1129|Synechococcus	1117|Cyanobacteria	Q	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
k59_712591_1	1349767.GJA_4997	6.84e-92	299.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,4726T@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_478674_1	240292.Ava_0884	1.29e-19	89.7	COG4664@1|root,COG4664@2|Bacteria,1G1UX@1117|Cyanobacteria,1HIYJ@1161|Nostocales	1117|Cyanobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_478674_2	572477.Alvin_2393	1.04e-11	67.8	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1WXYX@135613|Chromatiales	135613|Chromatiales	Q	TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_940820_1	1124780.ANNU01000023_gene3226	6.72e-120	363.0	COG0296@1|root,COG0296@2|Bacteria,4NECZ@976|Bacteroidetes,47NPV@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_279531_2	330214.NIDE3583	8.71e-30	108.0	COG0271@1|root,COG0271@2|Bacteria	2|Bacteria	T	Belongs to the BolA IbaG family	bolA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019538,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097428,GO:0097659,GO:0106035,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K05527,ko:K22066	-	-	-	-	ko00000,ko03000,ko03029	-	-	-	BolA
k59_679861_1	85643.Tmz1t_0843	1.54e-119	355.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,2KUS9@206389|Rhodocyclales	206389|Rhodocyclales	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_383840_1	1112217.PPL19_11047	8.36e-42	151.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_645934_1	247490.KSU1_C1241	1.9e-72	236.0	COG1217@1|root,COG1217@2|Bacteria,2IY3Q@203682|Planctomycetes	203682|Planctomycetes	T	membrane GTPase involved in stress response	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_352260_1	1123400.KB904780_gene1821	3.79e-23	100.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,4613W@72273|Thiotrichales	72273|Thiotrichales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_843245_1	1121940.AUDZ01000013_gene788	1.05e-38	137.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1XHAN@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_905806_1	983917.RGE_40500	3.4e-41	151.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VNHG@28216|Betaproteobacteria,1KK0T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HATPase_c_2,HisKA_3,LapD_MoxY_N,PAS,PAS_9
k59_940841_1	1168065.DOK_04167	7.95e-85	260.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1J8N0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EP	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
k59_449382_1	945713.IALB_0387	3.56e-95	291.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GAF,HTH_8,Sigma54_activat
k59_581720_1	1267534.KB906756_gene12	3.12e-70	237.0	COG0841@1|root,COG0841@2|Bacteria,3Y2TW@57723|Acidobacteria,2JIH3@204432|Acidobacteriia	204432|Acidobacteriia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_793008_1	469371.Tbis_1910	1.19e-61	209.0	COG3540@1|root,COG3540@2|Bacteria,2GJCI@201174|Actinobacteria,4DZX4@85010|Pseudonocardiales	201174|Actinobacteria	P	phosphatase	phoD	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
k59_793008_2	1449069.JMLO01000002_gene4604	6.55e-06	48.9	COG4097@1|root,COG4097@2|Bacteria,2H9AX@201174|Actinobacteria,4FVV7@85025|Nocardiaceae	201174|Actinobacteria	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
k59_449386_1	987059.RBXJA2T_03272	9.51e-147	450.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,1KJI2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_973542_1	113395.AXAI01000009_gene2589	1.56e-37	140.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_221285_1	489825.LYNGBM3L_46030	1.03e-22	99.4	COG0784@1|root,COG3300@1|root,COG4251@1|root,COG0784@2|Bacteria,COG3300@2|Bacteria,COG4251@2|Bacteria,1GPYK@1117|Cyanobacteria,1HI8A@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_4,PAS_9,PHY,Response_reg
k59_221285_2	1229909.NSED_05350	1.38e-09	58.2	COG0784@1|root,arCOG02391@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	ko:K03413,ko:K07662,ko:K07667	ko01503,ko02020,ko02024,ko02030,map01503,map02020,map02024,map02030	M00447,M00454,M00506,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CHASE4,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
k59_843274_1	994479.GL877878_gene3083	4.59e-41	154.0	COG4467@1|root,COG4467@2|Bacteria,2IDK7@201174|Actinobacteria	201174|Actinobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_773025_1	1232410.KI421417_gene2734	3.8e-35	137.0	2E2HF@1|root,32XMD@2|Bacteria,1N5B9@1224|Proteobacteria,42WRZ@68525|delta/epsilon subdivisions,2WRVW@28221|Deltaproteobacteria,43VYK@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_516356_1	288000.BBta_1648	1.31e-50	167.0	COG2755@1|root,COG2755@2|Bacteria,1MWT8@1224|Proteobacteria,2TTXF@28211|Alphaproteobacteria,3JRB1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_516356_2	47716.JOFH01000004_gene866	3.4e-20	92.0	COG0715@1|root,COG0715@2|Bacteria,2IEVS@201174|Actinobacteria	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
k59_973551_1	436308.Nmar_0201	4.49e-72	223.0	COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_973551_2	1229909.NSED_00810	2.41e-16	72.4	COG0640@1|root,arCOG00731@2157|Archaea,41T40@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_679917_1	983917.RGE_24110	9.76e-84	258.0	COG3115@1|root,COG3115@2|Bacteria,1NJ6D@1224|Proteobacteria,2VHQ7@28216|Betaproteobacteria,1KK6I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	-	-	-	-	-	-	-	-	-	ZipA_C
k59_745084_1	344747.PM8797T_27959	7.2e-66	206.0	COG3328@1|root,COG3328@2|Bacteria,2J0T4@203682|Planctomycetes	203682|Planctomycetes	L	COG3328 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_413794_1	1528106.JRJE01000004_gene601	7.61e-43	153.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,2JPVB@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	rkpK	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_1004573_1	1121405.dsmv_0407	3.16e-105	315.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MHW4@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_26433_1	543728.Vapar_3350	7.77e-38	134.0	COG0395@1|root,COG0395@2|Bacteria,1PFNZ@1224|Proteobacteria,2W9E3@28216|Betaproteobacteria,4AHXM@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_26433_2	1238450.VIBNISOn1_1420026	1e-89	274.0	COG2706@1|root,COG2706@2|Bacteria,1MUKZ@1224|Proteobacteria,1RPBK@1236|Gammaproteobacteria,1Y2IH@135623|Vibrionales	135623|Vibrionales	G	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
k59_844261_2	82996.sch_25625	2e-22	91.3	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,3ZZPC@613|Serratia	1236|Gammaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_353250_1	56780.SYN_02628	1.38e-55	189.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Glycosyl transferase, family 20	otsAB	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,S6PP,Trehalose_PPase
k59_124992_2	639283.Snov_0369	1.36e-68	224.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,3EYS0@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_479412_1	1288494.EBAPG3_24770	1.09e-108	336.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,371VX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_27376_2	1217718.ALOU01000029_gene787	9.49e-64	207.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,1K1P1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Periplasmic binding protein	btuF	-	-	ko:K02016,ko:K06858	ko02010,map02010	M00240,M00241	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.13,3.A.1.14	-	-	Peripla_BP_2
k59_27377_1	358681.BBR47_14470	2.16e-29	123.0	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_773762_1	469610.HMPREF0189_00997	1.24e-99	307.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KJ0V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_450386_1	323848.Nmul_A1854	3.54e-75	233.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2VIPK@28216|Betaproteobacteria,371MJ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
k59_450386_2	856793.MICA_2401	4.21e-14	72.4	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,4BPCJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_384805_1	391615.ABSJ01000030_gene806	7.79e-16	80.9	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1J4MQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_93071_1	1121918.ARWE01000001_gene3253	4.35e-116	343.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_799824_2	316057.RPD_3101	2.42e-15	72.4	2EHAM@1|root,33B2H@2|Bacteria,1RA0X@1224|Proteobacteria,2U5CB@28211|Alphaproteobacteria,3JYA8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_35685	-	-	-	-	-	-	-	-	-	-	-	-
k59_287752_1	335543.Sfum_2689	8.47e-51	181.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MQ5F@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_547149_1	398767.Glov_2152	2.9e-17	84.7	COG4966@1|root,COG4966@2|Bacteria,1R011@1224|Proteobacteria,43CPM@68525|delta/epsilon subdivisions,2X7WW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
k59_547173_1	1150469.RSPPHO_01246	3.12e-42	152.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,2JQSR@204441|Rhodospirillales	204441|Rhodospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_287810_1	543728.Vapar_2969	8.13e-45	160.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,2VH6J@28216|Betaproteobacteria,4ABDG@80864|Comamonadaceae	28216|Betaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Trp_halogenase
k59_1032389_1	1280001.BAOA01000163_gene2082	9.8e-129	376.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1XSAE@135623|Vibrionales	135623|Vibrionales	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_1032391_1	574087.Acear_1783	2.02e-53	181.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,3WBAE@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
k59_1032414_1	402777.KB235904_gene4190	1.23e-09	59.3	COG0004@1|root,COG0004@2|Bacteria,1G0S8@1117|Cyanobacteria,1H6WR@1150|Oscillatoriales	1117|Cyanobacteria	U	ammonium transporteR	amt1	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1032414_2	445973.CLOBAR_02077	1.97e-13	72.8	COG0004@1|root,COG0004@2|Bacteria,1W743@1239|Firmicutes,25896@186801|Clostridia,25UD3@186804|Peptostreptococcaceae	186801|Clostridia	P	Ammonium Transporter Family	-	-	-	-	-	-	-	-	-	-	-	-	Ammonium_transp
k59_287860_1	1120973.AQXL01000057_gene3098	0.000753	46.6	COG3039@1|root,COG3039@2|Bacteria,1TS6Q@1239|Firmicutes,4HD8C@91061|Bacilli	91061|Bacilli	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_287869_1	323848.Nmul_A2216	9.41e-87	269.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,372FB@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_547300_1	1229909.NSED_08325	2.19e-98	299.0	COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1032477_1	1469245.JFBG01000014_gene2019	3.45e-25	99.4	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,1WXAC@135613|Chromatiales	135613|Chromatiales	O	Redoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
k59_1032477_2	1294143.H681_12365	1.82e-24	97.8	COG1545@1|root,COG1545@2|Bacteria,1N2C8@1224|Proteobacteria,1SFMU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
k59_1032477_3	316056.RPC_1074	2.69e-107	320.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,3JRM3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
k59_1032503_1	1121405.dsmv_0139	3.58e-35	127.0	COG0589@1|root,COG0589@2|Bacteria,1N2PD@1224|Proteobacteria,42N6R@68525|delta/epsilon subdivisions,2WM1Y@28221|Deltaproteobacteria,2MN6E@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1032503_2	519989.ECTPHS_03854	6.86e-11	65.1	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_800086_1	323848.Nmul_A1969	5.82e-66	219.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2VKEE@28216|Betaproteobacteria,372CG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14
k59_547364_1	1380355.JNIJ01000011_gene858	1.61e-60	196.0	COG2084@1|root,COG2084@2|Bacteria,1RBRD@1224|Proteobacteria,2U7V8@28211|Alphaproteobacteria,3K435@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_547372_2	330214.NIDE0410	1.87e-145	412.0	COG0175@1|root,COG0175@2|Bacteria	2|Bacteria	EH	sulfate reduction	cysD	-	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_547376_1	1304866.K413DRAFT_4671	5.25e-13	70.1	COG1479@1|root,COG1479@2|Bacteria,1UT92@1239|Firmicutes,251YK@186801|Clostridia	186801|Clostridia	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF262
k59_547378_1	382245.ASA_2131	1.1e-47	162.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,1RP0B@1236|Gammaproteobacteria,1Y5BU@135624|Aeromonadales	135624|Aeromonadales	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
k59_1032594_1	1000565.METUNv1_03887	4.65e-118	354.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,2KUD5@206389|Rhodocyclales	206389|Rhodocyclales	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ
k59_800194_1	1265505.ATUG01000001_gene3236	1.27e-150	434.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MJ77@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Group II intron, maturase-specific domain	-	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_1032606_2	1000565.METUNv1_01904	3.58e-59	191.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,2KW82@206389|Rhodocyclales	28216|Betaproteobacteria	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	epsR	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_800213_1	1122197.ATWI01000010_gene1225	2.37e-43	145.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,4679E@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	translation initiation inhibitor, yjgF family	tdcF	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_800213_2	196367.JNFG01000018_gene4370	6.63e-46	157.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1K25Z@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_547471_1	987059.RBXJA2T_08068	7.38e-19	83.6	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,1KJPE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_547471_2	1232410.KI421426_gene1390	4.21e-46	160.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,42RJK@68525|delta/epsilon subdivisions,2WNEM@28221|Deltaproteobacteria,43UWP@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_800223_1	1049564.TevJSym_ar00370	5.99e-32	123.0	COG1142@1|root,COG1142@2|Bacteria,1RIXA@1224|Proteobacteria,1SBMD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_547486_1	1347342.BN863_24020	2.23e-33	132.0	COG0845@1|root,COG0845@2|Bacteria,4NF0X@976|Bacteroidetes,1HY9N@117743|Flavobacteriia	976|Bacteroidetes	M	Efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
k59_288155_1	323848.Nmul_A1210	3.37e-40	136.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,3731F@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_288155_2	1163617.SCD_n02737	5.15e-13	63.9	COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,2VY2T@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
k59_1032715_1	153721.MYP_253	3.6e-24	104.0	COG1748@1|root,COG1748@2|Bacteria,4NFM8@976|Bacteroidetes,47MT4@768503|Cytophagia	976|Bacteroidetes	E	Saccharopine dehydrogenase	-	-	1.5.1.10,1.5.1.7	ko:K00290,ko:K00293	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R02315	RC00215,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_1032715_2	658655.HMPREF0988_01466	1.35e-18	85.5	COG0078@1|root,COG1752@1|root,COG0078@2|Bacteria,COG1752@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,27IBN@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_288250_1	941824.TCEL_00781	1.23e-58	202.0	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,247J6@186801|Clostridia,36F38@31979|Clostridiaceae	186801|Clostridia	G	hydrolase family 65, central catalytic	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_800395_1	911045.PSE_1869	1.1e-109	332.0	COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1MY1V@1224|Proteobacteria,2U1WG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	PTS system, N-acetylglucosamine-specific	nagE	-	2.7.1.193,2.7.1.199	ko:K02778,ko:K02779,ko:K02803,ko:K02804	ko00010,ko00520,ko02060,ko05111,map00010,map00520,map02060,map05111	M00265,M00267	R02738,R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	PTS_EIIB,PTS_EIIC
k59_547651_1	1192124.LIG30_2865	1.06e-78	246.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,1K2EQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
k59_800455_1	1229909.NSED_03450	6.84e-43	150.0	COG0039@1|root,arCOG00246@2157|Archaea,41S7Z@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the LDH MDH superfamily	-	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_800455_2	1229909.NSED_09470	2.41e-12	65.1	COG1814@1|root,arCOG01096@2157|Archaea,41T0M@651137|Thaumarchaeota	651137|Thaumarchaeota	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_1032783_1	215803.DB30_6542	7.14e-20	86.7	COG0500@1|root,COG2226@2|Bacteria,1RC36@1224|Proteobacteria,42UDA@68525|delta/epsilon subdivisions,2WQHW@28221|Deltaproteobacteria,2YV8X@29|Myxococcales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_800490_1	338963.Pcar_1864	9.39e-67	212.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,42R8W@68525|delta/epsilon subdivisions,2WMZU@28221|Deltaproteobacteria,43UF9@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Formamidopyrimidine-DNA glycosylase H2TH domain	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_547720_1	56780.SYN_00295	6e-39	149.0	COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Alpha amylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,GDE_C,GDE_N
k59_1032804_1	504832.OCAR_6561	1.45e-93	280.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2TSVI@28211|Alphaproteobacteria,3JUFW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	hyi	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
k59_547726_1	472759.Nhal_2214	1.07e-75	242.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1WWCY@135613|Chromatiales	135613|Chromatiales	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_288392_1	1123393.KB891332_gene2771	1.64e-23	99.0	29ISC@1|root,2Z7VE@2|Bacteria,1MWUK@1224|Proteobacteria,2VP02@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_288392_2	690850.Desaf_0102	1.01e-52	179.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42T2T@68525|delta/epsilon subdivisions,2X5JV@28221|Deltaproteobacteria,2M9QF@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Na_sulph_symp
k59_800588_2	483219.LILAB_12125	8.8e-87	262.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,42KZX@68525|delta/epsilon subdivisions,2WM2N@28221|Deltaproteobacteria,2YWYT@29|Myxococcales	28221|Deltaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.381	ko:K16066	ko00240,ko00260,ko01100,map00240,map00260,map01100	-	R09289,R10851,R10852	RC00087,RC00525,RC03288	ko00000,ko00001,ko01000	-	-	-	adh_short
k59_547816_1	1380394.JADL01000010_gene4336	5.81e-89	272.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JPPW@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_547889_1	330214.NIDE2638	3.53e-110	344.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,3J0ZS@40117|Nitrospirae	40117|Nitrospirae	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_800687_1	1254432.SCE1572_06200	3.5e-29	113.0	2FJQV@1|root,34BDU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_547918_1	1415780.JPOG01000001_gene1831	1.31e-15	74.3	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria,1X82S@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_547918_2	1279017.AQYJ01000025_gene585	7.45e-09	57.0	COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,1RP6B@1236|Gammaproteobacteria,464ZU@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_288558_1	436308.Nmar_0267	1.04e-49	165.0	COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota	651137|Thaumarchaeota	C	oxidoreductase FAD NAD(P)-binding	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_800717_1	986075.CathTA2_2761	5.2e-14	73.6	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli	91061|Bacilli	G	C4-dicarboxylate ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1041351_2	1198452.Jab_2c11020	8.57e-30	112.0	COG2846@1|root,COG2846@2|Bacteria,1QX13@1224|Proteobacteria,2WH3K@28216|Betaproteobacteria,477Y9@75682|Oxalobacteraceae	28216|Betaproteobacteria	D	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_1041367_1	1265505.ATUG01000001_gene3195	3.82e-24	98.6	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria,2MJEP@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Zinc-binding dehydrogenase	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1041367_2	1121396.KB892968_gene978	1.03e-50	172.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2MJM9@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_811432_1	1244869.H261_06576	1.05e-67	220.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales	204441|Rhodospirillales	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_811525_1	948106.AWZT01000007_gene3533	4.9e-46	160.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,1K49A@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_811589_1	1459636.NTE_03553	8.12e-49	169.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1041518_2	1198114.AciX9_2073	4.69e-08	53.1	2DCBR@1|root,2ZDK1@2|Bacteria,3Y8SP@57723|Acidobacteria,2JNP6@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_811629_1	1380394.JADL01000005_gene5487	3.1e-99	301.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,2JPA7@204441|Rhodospirillales	204441|Rhodospirillales	I	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispDF	-	2.7.7.60,4.6.1.12	ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
k59_1041626_1	1125863.JAFN01000001_gene3383	8.19e-78	244.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_811761_1	196490.AUEZ01000129_gene1453	4.74e-82	252.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,3JX1Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1041650_1	497321.C664_09883	2.73e-113	341.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales	206389|Rhodocyclales	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_811818_1	987059.RBXJA2T_04283	1.29e-115	347.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJ7X@28216|Betaproteobacteria,1KJBC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtB	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_811820_1	426114.THI_2666	1.05e-35	137.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,1KJDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_811837_1	1121413.JMKT01000010_gene792	6.57e-27	106.0	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,42Q5T@68525|delta/epsilon subdivisions,2WKN4@28221|Deltaproteobacteria,2M9PC@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
k59_811873_1	391038.Bphy_2359	1.77e-177	503.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_811874_1	533240.CRC_02407	8.37e-85	263.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
k59_1041837_1	1532557.JL37_01190	3.21e-148	446.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,3T27D@506|Alcaligenaceae	28216|Betaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_1041858_1	443598.AUFA01000009_gene5678	6.71e-79	244.0	COG1028@1|root,COG1028@2|Bacteria,1MVA5@1224|Proteobacteria,2U2EZ@28211|Alphaproteobacteria,3JWQS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_21425	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_812116_2	321846.PS417_21155	9.44e-08	51.2	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria	1224|Proteobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
k59_812122_1	28444.JODQ01000017_gene6571	8.76e-30	112.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4EIYA@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
k59_1041958_1	1101195.Meth11DRAFT_0153	7.17e-48	160.0	COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,2VQ2A@28216|Betaproteobacteria,2KNP6@206350|Nitrosomonadales	206350|Nitrosomonadales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_365172_2	1267533.KB906737_gene1998	7.04e-15	75.5	2E3FB@1|root,32YE4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_854915_1	1163617.SCD_n02434	2.52e-86	286.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_920717_1	522306.CAP2UW1_1801	7.5e-36	136.0	COG1073@1|root,COG1073@2|Bacteria,1R9V1@1224|Proteobacteria,2VTA9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_659591_1	754477.Q7C_1965	2.56e-53	183.0	COG1029@1|root,COG1029@2|Bacteria,1R64R@1224|Proteobacteria,1RNM2@1236|Gammaproteobacteria,461UG@72273|Thiotrichales	72273|Thiotrichales	C	Formylmethanofuran dehydrogenase subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_887257_1	1125863.JAFN01000001_gene2478	1.94e-122	359.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_104325_1	765910.MARPU_03585	8.11e-92	283.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_594062_1	1500894.JQNN01000001_gene4497	7.6e-08	56.2	COG3416@1|root,COG3416@2|Bacteria,1P8CZ@1224|Proteobacteria,2VUVT@28216|Betaproteobacteria,477HR@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2076)	-	-	-	ko:K09945	-	-	-	-	ko00000	-	-	-	DUF2076
k59_854928_1	543728.Vapar_5097	1.53e-109	323.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,4AC31@80864|Comamonadaceae	28216|Betaproteobacteria	G	Fructose-bisphosphate aldolase, class II, Calvin cycle subtype	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_39033_1	543728.Vapar_6278	1.14e-36	135.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4AB79@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_462269_1	365046.Rta_18000	6.55e-57	190.0	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2VJEA@28216|Betaproteobacteria,4AARF@80864|Comamonadaceae	28216|Betaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_724720_2	525904.Tter_1321	1.1e-13	69.7	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_724720_3	1185766.DL1_13850	6.81e-13	68.9	COG0583@1|root,COG0583@2|Bacteria,1MXDT@1224|Proteobacteria,2TRY1@28211|Alphaproteobacteria,2XKGX@285107|Thioclava	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_397139_1	180281.CPCC7001_1979	8.67e-111	333.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,22SI1@167375|Cyanobium	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_594077_2	264402.Cagra.2175s0022.1.p	2.86e-27	108.0	COG0451@1|root,KOG1431@2759|Eukaryota,37MSP@33090|Viridiplantae,3GGUY@35493|Streptophyta,3HWWA@3699|Brassicales	35493|Streptophyta	GO	GDP-L-fucose synthase	-	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_496368_1	1313172.YM304_26560	4.84e-45	161.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4CNFD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome P450	-	-	1.14.15.14	ko:K20497	-	-	-	-	ko00000,ko00199,ko01000	-	-	-	p450
k59_920747_1	1500894.JQNN01000001_gene616	3.65e-69	220.0	COG0559@1|root,COG0559@2|Bacteria,1MVZ5@1224|Proteobacteria,2VJCG@28216|Betaproteobacteria,478G9@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_430497_1	1125973.JNLC01000018_gene2096	9.26e-73	223.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,3JQR4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	MA20_17490	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_626604_1	765911.Thivi_2947	8.8e-97	298.0	COG5659@1|root,COG5659@2|Bacteria,1MXSA@1224|Proteobacteria,1SN54@1236|Gammaproteobacteria,1X0AV@135613|Chromatiales	135613|Chromatiales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1014807_1	391615.ABSJ01000026_gene121	8.02e-78	245.0	2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_202216_1	592015.HMPREF1705_00579	2.03e-59	196.0	COG4313@1|root,COG4313@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_6494_1	977880.RALTA_A1877	3.75e-40	146.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1K0NH@119060|Burkholderiaceae	28216|Betaproteobacteria	T	nitrogen regulation protein	ntrC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_6494_2	582744.Msip34_2494	2.17e-105	316.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,2KKW6@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_137100_1	404589.Anae109_1805	2.78e-51	176.0	COG3005@1|root,COG3005@2|Bacteria,1QYG3@1224|Proteobacteria,43CC8@68525|delta/epsilon subdivisions,2X7N4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_561602_1	1437824.BN940_16281	3.43e-86	264.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,3T2FT@506|Alcaligenaceae	28216|Betaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_6497_1	265072.Mfla_1124	1.83e-54	191.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,2KKKE@206350|Nitrosomonadales	206350|Nitrosomonadales	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_920764_1	748247.AZKH_1050	1.06e-84	251.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,2VQ31@28216|Betaproteobacteria,2KYR2@206389|Rhodocyclales	206389|Rhodocyclales	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_137102_1	1123487.KB892868_gene1118	1.93e-09	60.1	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,2KUX1@206389|Rhodocyclales	206389|Rhodocyclales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_137102_2	1216967.L100_14897	5.08e-28	106.0	2DNS7@1|root,32YWC@2|Bacteria,4NSJ6@976|Bacteroidetes,1I4FI@117743|Flavobacteriia,34RMM@308865|Elizabethkingia	976|Bacteroidetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_561611_2	1037409.BJ6T_79110	5.36e-32	122.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VFXC@28211|Alphaproteobacteria,3K61J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_365240_1	204773.HEAR0348	2.74e-88	268.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,4765G@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_202230_1	864051.BurJ1DRAFT_2573	3.62e-84	250.0	COG3384@1|root,COG3384@2|Bacteria,1RA8A@1224|Proteobacteria,2VQ2B@28216|Betaproteobacteria,1KKQH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Aromatic-ring-opening dioxygenase LigAB, LigA subunit	-	-	1.13.11.8	ko:K04100	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA
k59_202230_2	1286631.X805_22620	2.8e-09	56.6	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria,1KKIV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	ligB	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
k59_233906_1	1235457.C404_29270	2.46e-45	155.0	COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,2VRMX@28216|Betaproteobacteria,1K3N8@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_202237_1	1123242.JH636436_gene370	1.02e-17	85.9	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_16,TPR_19,TPR_2
k59_724767_1	519989.ECTPHS_00235	1.11e-97	300.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1WW7Z@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_756103_1	987059.RBXJA2T_05268	2.51e-112	340.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,1KJD0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_887330_1	1454004.AW11_01979	8.9e-52	175.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VJI5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_985481_1	794903.OPIT5_28990	3.77e-16	80.9	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,46THX@74201|Verrucomicrobia,3K9B4@414999|Opitutae	414999|Opitutae	L	UvrD-like helicase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
k59_985481_2	203907.Bfl028	1.22e-14	70.5	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,283CS@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_561627_1	497321.C664_04067	3.86e-119	353.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VMHS@28216|Betaproteobacteria,2KUQ2@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the thiolase family	fadA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_233911_1	1121396.KB893053_gene2363	2.62e-85	274.0	COG4222@1|root,COG4222@2|Bacteria,1R2H4@1224|Proteobacteria	1224|Proteobacteria	S	Esterase-like activity of phytase	-	-	-	-	-	-	-	-	-	-	-	-	Phytase-like
k59_431412_2	305700.B447_21277	7.59e-25	107.0	COG1587@1|root,COG2959@1|root,COG1587@2|Bacteria,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,2VMG1@28216|Betaproteobacteria,2KW9U@206389|Rhodocyclales	206389|Rhodocyclales	H	HemX, putative uroporphyrinogen-III C-methyltransferase	hemX	-	2.1.1.107	ko:K02496	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	HemX
k59_333741_1	1121405.dsmv_0318	1.82e-32	125.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2MHY9@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_333741_2	439235.Dalk_0905	2.77e-20	87.8	COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MI1A@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_627547_1	1278309.KB907103_gene1172	6.4e-16	83.6	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,1XJ26@135619|Oceanospirillales	135619|Oceanospirillales	EGP	Sugar (and other) transporter	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_300684_1	929713.NIASO_17705	6.64e-13	68.9	COG4667@1|root,COG4667@2|Bacteria,4NF0K@976|Bacteroidetes	976|Bacteroidetes	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_105338_1	1158292.JPOE01000002_gene3653	2.35e-70	233.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,1KJSP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_300693_1	744980.TRICHSKD4_2960	7.98e-69	218.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_693271_1	663610.JQKO01000003_gene1470	7e-64	202.0	COG0546@1|root,COG0546@2|Bacteria,1QEY0@1224|Proteobacteria,2U4WX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_562600_1	395495.Lcho_4111	1.62e-95	291.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,1KJIE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_7525_1	62928.azo2289	1.75e-92	278.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,2WFS6@28216|Betaproteobacteria,2KUWN@206389|Rhodocyclales	206389|Rhodocyclales	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
k59_823846_1	290397.Adeh_2245	2.9e-88	274.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria,2YTUB@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_170669_2	138119.DSY0310	7.87e-67	214.0	COG2221@1|root,COG2221@2|Bacteria,1TZD2@1239|Firmicutes,24DEF@186801|Clostridia,2610K@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM sulfite reductase, dissimilatory-type beta subunit	dsrB	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr
k59_725753_1	1459636.NTE_01058	7.24e-17	80.1	arCOG04732@1|root,arCOG04732@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_725753_2	1459636.NTE_01048	1.93e-11	65.1	COG0624@1|root,arCOG01110@2157|Archaea,41SAE@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_366170_1	622637.KE124774_gene3545	2.27e-69	226.0	COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,2U0Y8@28211|Alphaproteobacteria,36ZP7@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1015344_1	1121864.OMO_01316	3.9e-31	130.0	COG5283@1|root,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,4HEHJ@91061|Bacilli	91061|Bacilli	D	Phage-related minor tail protein	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_595064_1	1382359.JIAL01000001_gene2614	8.57e-92	282.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_39997_2	754252.PFREUD_13580	2.04e-21	93.6	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4DNT7@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_268587_1	521098.Aaci_2021	3.93e-45	157.0	COG0500@1|root,COG2226@2|Bacteria,1V7TR@1239|Firmicutes,4HJ1N@91061|Bacilli	91061|Bacilli	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
k59_497397_1	666509.RCA23_c27000	2.42e-60	201.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	GO:0003674,GO:0003824,GO:0004029,GO:0004030,GO:0006725,GO:0008150,GO:0008152,GO:0009058,GO:0009698,GO:0009699,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019438,GO:0019748,GO:0044237,GO:0044249,GO:0044550,GO:0050269,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901576	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_562619_1	156889.Mmc1_2182	1.81e-37	128.0	COG0011@1|root,COG0011@2|Bacteria,1N0UT@1224|Proteobacteria,2UV1A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
k59_397818_1	153948.NAL212_1089	9.19e-16	78.2	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,371X2@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_397818_2	335283.Neut_0775	1.01e-57	189.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,37292@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
k59_756747_1	713586.KB900536_gene1694	6.15e-69	210.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_756747_2	1266909.AUAG01000001_gene1585	3.32e-10	57.8	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria,1WYZY@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_105360_1	1415778.JQMM01000001_gene245	2.89e-29	108.0	2C46F@1|root,32SRD@2|Bacteria,1N540@1224|Proteobacteria,1S8P6@1236|Gammaproteobacteria,1J6QG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_105360_2	269799.Gmet_0230	1.54e-51	166.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,437CT@68525|delta/epsilon subdivisions,2XA0U@28221|Deltaproteobacteria,43VKC@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_823867_1	580332.Slit_2564	2.11e-104	323.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2VMAN@28216|Betaproteobacteria,44WCY@713636|Nitrosomonadales	28216|Betaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_660669_1	1125973.JNLC01000018_gene2320	1.74e-47	165.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_725776_1	1229909.NSED_03465	1.59e-86	265.0	COG0517@1|root,arCOG00600@2157|Archaea	2157|Archaea	K	CBS domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
k59_366186_2	268746.Q58ML7_BPPRM	2.84e-29	113.0	4QAQQ@10239|Viruses,4QVZX@35237|dsDNA viruses  no RNA stage,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae	10662|Myoviridae	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_894029_1	1196031.ALEG01000041_gene2638	5.89e-71	227.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4HBEA@91061|Bacilli,1ZAY4@1386|Bacillus	91061|Bacilli	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	acoA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
k59_530917_1	1174528.JH992898_gene4707	6.5e-33	128.0	COG4467@1|root,COG4467@2|Bacteria,1G4QI@1117|Cyanobacteria,1JJ9H@1189|Stigonemataceae	1117|Cyanobacteria	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_209164_1	933262.AXAM01000187_gene859	1.7e-35	129.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,42NNJ@68525|delta/epsilon subdivisions,2WKP9@28221|Deltaproteobacteria,2MKV7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,DUF2924,Transposase_20
k59_339905_1	1158292.JPOE01000005_gene250	6.79e-24	99.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,1KJ7K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
k59_339905_2	1165096.ARWF01000001_gene692	1.48e-95	294.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,2KKKG@206350|Nitrosomonadales	206350|Nitrosomonadales	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_960647_1	1348114.OM33_16190	4.48e-82	270.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q42B@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_601241_1	595460.RRSWK_01367	7.93e-21	95.1	COG5361@1|root,COG5361@2|Bacteria,2IYY0@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_928078_1	395495.Lcho_4066	1.33e-39	148.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1KMZY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_568880_1	420324.KI912061_gene6197	5.57e-16	82.4	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4
k59_209177_1	1286170.RORB6_09830	3.72e-23	93.2	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	part of a sulfur-relay system	tusE	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_239676_2	2340.JV46_14060	2.21e-39	144.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,1RS2Z@1236|Gammaproteobacteria,1J92V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_176868_1	1454004.AW11_01051	1.65e-41	142.0	2CB7M@1|root,31H4T@2|Bacteria,1MYWT@1224|Proteobacteria,2VSTJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_830245_1	243233.MCA1632	2.17e-64	221.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales	135618|Methylococcales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_861878_1	439235.Dalk_1317	9.03e-110	329.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_273206_1	351348.Maqu_0100	2.36e-34	135.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,4667H@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,Response_reg,TPR_12,TPR_7,TPR_8
k59_402959_1	1163617.SCD_n00281	4.07e-68	229.0	2A8Z1@1|root,30Y2U@2|Bacteria,1PJYG@1224|Proteobacteria,2VJ83@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_306438_1	1162668.LFE_2157	1.98e-68	226.0	COG1032@1|root,COG1032@2|Bacteria,3J18Y@40117|Nitrospirae	40117|Nitrospirae	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_402966_1	83406.HDN1F_27670	3.2e-118	358.0	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1J4MV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	Short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
k59_503699_1	330214.NIDE1937	2.29e-105	334.0	COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_437403_1	1487923.DP73_04745	1.93e-82	251.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,1V3TD@1239|Firmicutes,24F9C@186801|Clostridia,264MB@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_240557_1	1121121.KB894289_gene2678	4.12e-43	160.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Beta-lactamase,Condensation,PP-binding
k59_993376_1	398578.Daci_4442	1.56e-06	49.3	COG1082@1|root,COG1082@2|Bacteria,1QYE4@1224|Proteobacteria,2VJQ6@28216|Betaproteobacteria,4ABF5@80864|Comamonadaceae	28216|Betaproteobacteria	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_993376_2	497321.C664_11600	9.5e-81	248.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VHYD@28216|Betaproteobacteria,2M00B@206389|Rhodocyclales	206389|Rhodocyclales	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase_5
k59_240559_1	350054.Mflv_4763	6.14e-32	125.0	COG2801@1|root,COG2801@2|Bacteria,2HBU8@201174|Actinobacteria,236HP@1762|Mycobacteriaceae	201174|Actinobacteria	L	PFAM Integrase, catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_468970_1	903818.KI912268_gene3131	7.43e-21	96.3	COG3437@1|root,COG4252@1|root,COG3437@2|Bacteria,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc,HD,HD_5
k59_340903_2	426114.THI_1599	6.3e-61	194.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VHHB@28216|Betaproteobacteria,1KKQG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_894993_1	631454.N177_1930	1.57e-64	204.0	COG1126@1|root,COG1126@2|Bacteria,1MWKQ@1224|Proteobacteria,2TSCU@28211|Alphaproteobacteria,1JQ5M@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
k59_14891_1	1550091.JROE01000002_gene922	6.62e-08	52.0	COG3339@1|root,COG3339@2|Bacteria,4PK3A@976|Bacteroidetes,1IYAN@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_14891_2	1168034.FH5T_04765	8.05e-41	142.0	COG0253@1|root,COG0253@2|Bacteria,4NF26@976|Bacteroidetes,2FNI4@200643|Bacteroidia	976|Bacteroidetes	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_700797_1	402881.Plav_0173	6.84e-77	251.0	COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,2TZDG@28211|Alphaproteobacteria,1JNHY@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C
k59_14892_1	1229909.NSED_06930	5.27e-21	83.2	COG2093@1|root,arCOG04077@2157|Archaea,41SVE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
k59_14892_2	1229909.NSED_06925	5.01e-95	280.0	COG1095@1|root,arCOG00675@2157|Archaea,41SGF@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
k59_177826_1	1323361.JPOC01000028_gene4005	4.86e-41	147.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4FYJ5@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	1.17.1.1,4.2.1.164	ko:K12452,ko:K13328	ko00520,ko00523,ko01130,map00520,map00523,map01130	M00802	R03391,R03392,R08930	RC00230,RC00704	ko00000,ko00001,ko00002,ko01000	-	-	-	DegT_DnrJ_EryC1
k59_993393_2	608538.HTH_0285	1.86e-08	57.8	COG1333@1|root,COG1333@2|Bacteria,2G400@200783|Aquificae	200783|Aquificae	O	ResB family	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
k59_504676_1	751994.AGIG01000034_gene615	9.84e-60	202.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1J9VK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.2.5.3,1.3.99.8	ko:K03520,ko:K16877,ko:K20171	ko00365,ko00760,ko01120,map00365,map00760,map01120	M00811	R02987,R11168,R11179	RC00589,RC01856,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,COXG
k59_504676_2	1158292.JPOE01000002_gene2285	5.63e-18	79.7	COG3427@1|root,COG3427@2|Bacteria,1MYBY@1224|Proteobacteria,2VWJR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	-	-	-	-	-	-	-	-	-	COXG
k59_862853_2	7029.ACYPI084111-PA	5.33e-19	84.7	2E1I0@1|root,2S8UZ@2759|Eukaryota,3A9DK@33154|Opisthokonta,3BV6P@33208|Metazoa,3DC7S@33213|Bilateria,4233M@6656|Arthropoda	7029.ACYPI084111-PA|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_993395_1	926692.AZYG01000054_gene2287	5.75e-20	86.7	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3WB27@53433|Halanaerobiales	186801|Clostridia	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_468985_1	713587.THITH_12790	1.35e-97	300.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1WVVJ@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_468985_2	1123261.AXDW01000007_gene2271	1.43e-22	96.3	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1X3HS@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_403818_2	234267.Acid_5283	2.05e-15	76.6	COG0436@1|root,COG0436@2|Bacteria,3Y2VQ@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_373077_1	1125973.JNLC01000018_gene2320	5.03e-135	400.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_468988_1	1123279.ATUS01000001_gene2491	4.09e-39	139.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1J4QV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	stress-induced protein	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_961692_1	945713.IALB_1849	3.57e-90	282.0	COG0768@1|root,COG0768@2|Bacteria	2|Bacteria	M	penicillin binding	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
k59_569939_2	399739.Pmen_3543	2.53e-09	58.5	COG2890@1|root,COG2890@2|Bacteria,1MY5I@1224|Proteobacteria,1T26C@1236|Gammaproteobacteria,1YM01@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31,PrmA
k59_993408_1	153948.NAL212_0240	6.22e-37	134.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,3725K@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_993408_2	1163617.SCD_n02482	1.78e-45	156.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_733233_2	266264.Rmet_2761	4.95e-85	277.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1K5NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_634665_1	228410.NE0342	1.2e-60	189.0	COG3293@1|root,COG3293@2|Bacteria,1N0VW@1224|Proteobacteria,2WEPA@28216|Betaproteobacteria,3732J@32003|Nitrosomonadales	28216|Betaproteobacteria	L	COGs COG3293	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_668040_1	887898.HMPREF0551_1031	2.59e-70	236.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,1K2J6@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_733235_1	338969.Rfer_3094	5.56e-71	237.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,4AE6V@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_145312_1	1288494.EBAPG3_5130	2.67e-102	314.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,372TA@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	lpdA	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_668041_1	1026882.MAMP_01496	1.58e-102	306.0	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,1RRYS@1236|Gammaproteobacteria,4624P@72273|Thiotrichales	72273|Thiotrichales	P	ZIP Zinc transporter	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
k59_504698_1	1114856.C496_22154	1.55e-16	79.3	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,240TR@183963|Halobacteria	183963|Halobacteria	E	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_468990_1	265072.Mfla_1047	1.25e-242	673.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VH4Z@28216|Betaproteobacteria,2KM2W@206350|Nitrosomonadales	206350|Nitrosomonadales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.2,2.6.1.66	ko:K14260	ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230	-	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_468990_2	977880.RALTA_A1810	1.14e-94	289.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,1JZRK@119060|Burkholderiaceae	28216|Betaproteobacteria	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_929144_1	522306.CAP2UW1_3922	1.03e-84	261.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2VIFF@28216|Betaproteobacteria,1KPZ1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_210156_1	859657.RPSI07_1429	9.86e-72	224.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria,1K0C0@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30,5.4.2.9	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	-	R00409,R00661	RC00286,RC00287,RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_47193_1	1288494.EBAPG3_5450	3.56e-90	278.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,37240@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_895045_1	1459636.NTE_00035	1.39e-31	117.0	COG1846@1|root,arCOG03748@2157|Archaea,41T7R@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_895045_2	1459636.NTE_00059	1.01e-08	56.6	COG0475@1|root,arCOG01955@2157|Archaea,41SG1@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
k59_634679_1	1280950.HJO_02030	1.53e-26	108.0	COG0607@1|root,COG0607@2|Bacteria,1MZG3@1224|Proteobacteria,2U1W0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0607 Rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_145324_1	653948.CCA14937	0.000581	47.4	COG0664@1|root,KOG0614@2759|Eukaryota	2759|Eukaryota	T	cGMP-dependent protein kinase activity	-	-	2.7.11.12	ko:K07376,ko:K19477	ko04022,ko04270,ko04540,ko04611,ko04713,ko04714,ko04730,ko04740,ko04923,ko04924,ko04970,map04022,map04270,map04540,map04611,map04713,map04714,map04730,map04740,map04923,map04924,map04970	M00694	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	Pkinase,WD40,cNMP_binding
k59_831357_1	335659.S23_62210	8.09e-97	303.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TS3K@28211|Alphaproteobacteria,3JUFH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	MA20_06195	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_895050_1	1454004.AW11_02019	2.69e-111	350.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria	28216|Betaproteobacteria	G	SMART alpha amylase, catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_469001_1	1163617.SCD_n00281	8.89e-43	157.0	2A8Z1@1|root,30Y2U@2|Bacteria,1PJYG@1224|Proteobacteria,2VJ83@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_14957_1	935848.JAEN01000014_gene1738	2.44e-17	81.3	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2TSP6@28211|Alphaproteobacteria,2PUHF@265|Paracoccus	28211|Alphaproteobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_14957_2	1286093.C266_19470	1.68e-56	186.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2VIBX@28216|Betaproteobacteria,1K0D3@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_831368_1	221288.JH992901_gene4388	9.27e-57	183.0	COG1028@1|root,COG1028@2|Bacteria,1G4JP@1117|Cyanobacteria,1JIJE@1189|Stigonemataceae	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_993438_1	945713.IALB_0565	6.17e-17	87.4	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
k59_929161_1	557598.LHK_00530	4.71e-214	597.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,2KPT9@206351|Neisseriales	206351|Neisseriales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_929161_2	323848.Nmul_A1095	2.56e-77	234.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2VQD9@28216|Betaproteobacteria,371SU@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_929161_3	543913.D521_0751	1.05e-80	252.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,1KPUT@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_112660_1	2340.JV46_06490	3.6e-85	263.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1J4F3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_707705_1	228410.NE1045	3.03e-84	265.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,372BT@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_409485_1	323848.Nmul_A1770	3.11e-18	83.6	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,372H8@32003|Nitrosomonadales	28216|Betaproteobacteria	T	protein synthesis factor, GTP-binding	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_935958_1	1121918.ARWE01000001_gene3103	4.1e-45	157.0	COG0589@1|root,COG0589@2|Bacteria,1QR0W@1224|Proteobacteria,42SGI@68525|delta/epsilon subdivisions,2WPQY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_901242_1	65093.PCC7418_2749	9.16e-106	326.0	COG2936@1|root,COG2936@2|Bacteria,1G1U8@1117|Cyanobacteria	1117|Cyanobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_277371_2	991905.SL003B_1082	1.97e-94	288.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TSEI@28211|Alphaproteobacteria,4BS2Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_87843_1	1403819.BATR01000124_gene4405	1.73e-05	50.1	2EYVG@1|root,33S2J@2|Bacteria	2|Bacteria	S	N-acetyltransferase	-	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
k59_769230_1	330214.NIDE3677	1.74e-81	247.0	297W1@1|root,2ZV2M@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4396)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4396
k59_969355_1	748247.AZKH_p0306	1.8e-91	278.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,2KXTK@206389|Rhodocyclales	206389|Rhodocyclales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_120063_1	1121405.dsmv_2232	7.02e-88	268.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2MIG1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_152710_1	987059.RBXJA2T_18688	1.88e-99	297.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1KKER@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp1	-	3.1.3.11,3.1.3.37	ko:K01086,ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
k59_445507_1	426114.THI_0648	5.01e-11	62.8	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,1KIWA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_445507_2	261292.Nit79A3_2120	1.28e-90	276.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,371XR@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_740876_1	94122.Shewana3_3549	1.92e-74	243.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,2QAHK@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_641918_1	234267.Acid_3090	4.05e-13	74.3	COG1804@1|root,COG1804@2|Bacteria,3Y7RD@57723|Acidobacteria	57723|Acidobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_348233_1	394503.Ccel_2974	2.64e-23	103.0	2E7G4@1|root,331Z0@2|Bacteria,1VVH5@1239|Firmicutes,25176@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_936695_1	240302.BN982_02112	6.48e-33	128.0	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,4HAK9@91061|Bacilli,3NDA8@45667|Halobacillus	91061|Bacilli	S	Domain of unknown function (DUF1732)	yloC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_475180_1	1279009.ADICEAN_02846	1.04e-44	167.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,4NJMJ@976|Bacteroidetes	976|Bacteroidetes	KT	PFAM Stage II sporulation	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
k59_152723_1	1380387.JADM01000002_gene1944	1.14e-89	277.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1XH72@135619|Oceanospirillales	135619|Oceanospirillales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_184905_2	420662.Mpe_A0638	4.05e-19	84.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,1KJXH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	reductase	fabG	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_54239_1	396588.Tgr7_1110	2.02e-47	174.0	COG2159@1|root,COG2159@2|Bacteria,1QDV1@1224|Proteobacteria,1RYCT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_348249_2	304371.MCP_0087	6.81e-19	80.5	COG1324@1|root,arCOG04231@2157|Archaea,2XYPN@28890|Euryarchaeota,2NA01@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
k59_475185_1	265729.GS18_0208060	7.01e-19	89.4	COG4587@1|root,COG4587@2|Bacteria,1TSAN@1239|Firmicutes,4HBVU@91061|Bacilli,1ZBKH@1386|Bacillus	91061|Bacilli	S	ABC transporter (permease)	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_6
k59_22385_1	1408473.JHXO01000005_gene1613	4.79e-88	273.0	COG0477@1|root,COG2814@2|Bacteria,4NFRE@976|Bacteroidetes	976|Bacteroidetes	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_217403_1	1232410.KI421413_gene558	1.9e-87	268.0	COG0436@1|root,COG0436@2|Bacteria,1QW10@1224|Proteobacteria,42MQA@68525|delta/epsilon subdivisions,2WJDK@28221|Deltaproteobacteria,43S5R@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	bamJ	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_475190_1	634956.Geoth_1219	5.25e-31	114.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,1WEZT@129337|Geobacillus	91061|Bacilli	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_901952_1	977880.RALTA_A1696	7.15e-75	245.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,1K0GW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_380114_1	338969.Rfer_2160	5.33e-208	610.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_839040_1	522306.CAP2UW1_3430	1.69e-66	215.0	COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,2VPY4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_839040_2	765911.Thivi_1751	2.72e-67	214.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1WXNW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_217409_1	1121035.AUCH01000003_gene1160	7.29e-60	201.0	COG3863@1|root,COG3863@2|Bacteria,1R3R2@1224|Proteobacteria,2VRR0@28216|Betaproteobacteria,2KYEG@206389|Rhodocyclales	206389|Rhodocyclales	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
k59_534940_1	1485544.JQKP01000007_gene2024	1.83e-23	105.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,44W8H@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Histidine Phosphotransfer domain	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_870338_1	765911.Thivi_0478	9.9e-64	204.0	COG3039@1|root,COG3039@2|Bacteria,1N88K@1224|Proteobacteria	1224|Proteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
k59_512211_1	1056820.KB900674_gene2579	1.42e-117	348.0	COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,1RPBI@1236|Gammaproteobacteria,2PP6J@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	C	Nitrogenase component 1 type Oxidoreductase	nifN	-	-	ko:K02592	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
k59_769273_1	1121405.dsmv_2310	1.47e-15	78.2	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42U0W@68525|delta/epsilon subdivisions,2WQRX@28221|Deltaproteobacteria,2MPQV@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_217416_1	1297863.APJF01000019_gene2387	0.000168	43.1	COG1028@1|root,COG1028@2|Bacteria,1MU32@1224|Proteobacteria,2TUYY@28211|Alphaproteobacteria,3JUT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_217416_2	1121448.DGI_0184	2.51e-23	102.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M9AP@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_475208_1	1502770.JQMG01000001_gene800	3.32e-88	274.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KM7W@206350|Nitrosomonadales	206350|Nitrosomonadales	T	Sigma-54 interaction domain	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_87904_1	984262.SGRA_0505	2.73e-17	80.9	COG2825@1|root,COG2825@2|Bacteria,4NH46@976|Bacteroidetes,1IS3M@117747|Sphingobacteriia	976|Bacteroidetes	M	outer membrane chaperone Skp (OmpH)	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_740918_1	1123392.AQWL01000002_gene1978	1.21e-139	429.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KSKV@119069|Hydrogenophilales	119069|Hydrogenophilales	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_22417_1	713586.KB900536_gene109	5.77e-97	290.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,1RSP8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_839058_1	580332.Slit_0734	1.65e-15	72.4	COG0071@1|root,COG0071@2|Bacteria,1PV6Z@1224|Proteobacteria,2WA7J@28216|Betaproteobacteria,44WMZ@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_839058_2	479435.Kfla_3709	1.17e-10	62.8	COG2847@1|root,COG2847@2|Bacteria,2IR3D@201174|Actinobacteria,4DS2B@85009|Propionibacteriales	201174|Actinobacteria	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
k59_839058_3	323848.Nmul_A1991	5.49e-31	120.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,3721U@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_870355_1	330214.NIDE4377	6.05e-261	725.0	COG0488@1|root,COG0488@2|Bacteria,3J0WR@40117|Nitrospirae	40117|Nitrospirae	S	ABC transporter	-	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1000686_1	1449065.JMLL01000010_gene479	1.86e-50	171.0	COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,2TUD2@28211|Alphaproteobacteria,43ITU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
k59_675721_2	1211115.ALIQ01000196_gene65	8.19e-21	90.5	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria	1224|Proteobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_641978_1	945713.IALB_0009	2.07e-83	265.0	COG0326@1|root,COG0326@2|Bacteria	2|Bacteria	O	unfolded protein binding	htpG	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:1901700,GO:1901701	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_512235_1	1131266.ARWQ01000005_gene826	3.09e-81	251.0	COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_410206_1	522306.CAP2UW1_2839	5.69e-107	317.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria,1KQIA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	Q	Dienelactone hydrolase family	clcD	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_936768_1	999423.HMPREF9161_00992	1.65e-09	60.8	COG3914@1|root,COG3914@2|Bacteria	2|Bacteria	O	protein N-acetylglucosaminyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Methyltransf_21,TPR_16,TPR_8
k59_445581_1	1382230.ASAP_2020	6.09e-34	132.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TSB6@28211|Alphaproteobacteria,2JQHC@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_445581_2	63737.Npun_F1046	2.46e-80	266.0	COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria,1HR8B@1161|Nostocales	1117|Cyanobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1022692_1	331869.BAL199_12236	2.18e-38	139.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	MA20_01265	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_1022692_2	702113.PP1Y_AT21473	4.39e-17	81.6	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria,2K1WC@204457|Sphingomonadales	204457|Sphingomonadales	V	Secretion protein, HlyD	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_577545_1	879212.DespoDRAFT_01048	1.65e-78	256.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_512261_1	411467.BACCAP_00341	3.17e-105	315.0	COG0078@1|root,COG0078@2|Bacteria,1TNY4@1239|Firmicutes,249P4@186801|Clostridia,26870@186813|unclassified Clostridiales	186801|Clostridia	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	ygeW	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
k59_152801_1	395494.Galf_0840	8.79e-78	247.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,44V7R@713636|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_152801_2	497321.C664_01475	9.18e-59	195.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,2KVFJ@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_348326_1	391038.Bphy_5504	6.21e-79	262.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_120166_1	330214.NIDE0499	3.43e-27	102.0	COG4696@1|root,COG4696@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	XK27_03185	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	Acetyltransf_3,Hydrolase_3,PRA-PH
k59_120166_2	330214.NIDE0498	3.11e-29	115.0	COG1322@1|root,COG1322@2|Bacteria,3J15T@40117|Nitrospirae	40117|Nitrospirae	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_870389_1	102125.Xen7305DRAFT_00004670	1.78e-46	161.0	COG3259@1|root,COG3259@2|Bacteria,1G1C8@1117|Cyanobacteria,3VIVS@52604|Pleurocapsales	1117|Cyanobacteria	C	Coenzyme F420-reducing hydrogenase, alpha subunit	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	iJN678.hoxH	NiFeSe_Hases
k59_870389_2	98439.AJLL01000016_gene1691	1.04e-43	147.0	COG1941@1|root,COG1941@2|Bacteria,1G2I6@1117|Cyanobacteria	1117|Cyanobacteria	C	Coenzyme F420-reducing hydrogenase, gamma subunit	hoxY	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	iJN678.hoxY	Oxidored_q6
k59_445592_1	243233.MCA0538	6.45e-114	342.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,1XE2Z@135618|Methylococcales	135618|Methylococcales	O	Peptidase, M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_839109_1	1121035.AUCH01000001_gene1928	1.91e-52	176.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,2KUA0@206389|Rhodocyclales	206389|Rhodocyclales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_609727_1	1288494.EBAPG3_15680	1.56e-134	410.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,371W3@32003|Nitrosomonadales	28216|Betaproteobacteria	C	dehydrogenase, E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_740985_1	748247.AZKH_2404	9.18e-47	164.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2WGST@28216|Betaproteobacteria,2KYB6@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_348348_1	344747.PM8797T_21028	3.76e-09	62.4	COG1520@1|root,COG1864@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG5492@1|root,COG1520@2|Bacteria,COG1864@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,COG5492@2|Bacteria,2IY9M@203682|Planctomycetes	203682|Planctomycetes	Q	DNA RNA non-specific endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_740990_1	1163617.SCD_n00924	3.2e-46	165.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_740990_2	634497.HAH_0935	3.56e-23	99.4	COG0294@1|root,arCOG02817@2157|Archaea,2XTGI@28890|Euryarchaeota,23S24@183963|Halobacteria	183963|Halobacteria	H	COG0285 Folylpolyglutamate synthase	folCP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,Pterin_bind
k59_512287_1	330214.NIDE0609	1.51e-115	358.0	COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae	40117|Nitrospirae	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
k59_22472_1	320840.Q4ZCD8_9CAUD	0.00018	53.9	4QFFG@10239|Viruses	10239|Viruses	S	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_348359_1	522306.CAP2UW1_1014	1.36e-55	191.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KQIU@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_22478_1	247634.GPB2148_1596	5.53e-92	276.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1J4RX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197	ACCA
k59_246973_1	1163617.SCD_n00948	1.47e-20	86.7	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_585099_2	589865.DaAHT2_0912	1.36e-81	254.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2MI9Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_877369_1	498761.HM1_2133	6.2e-18	82.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_877369_2	525904.Tter_0281	2.07e-07	55.5	COG1656@1|root,COG1977@1|root,COG1656@2|Bacteria,COG1977@2|Bacteria,2NPUJ@2323|unclassified Bacteria	2|Bacteria	H	Mut7-C RNAse domain	-	-	-	ko:K03636,ko:K09122	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	Mut7-C,Ub-Mut7C
k59_775758_1	709986.Deima_2139	7.4e-31	120.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	irk	-	-	ko:K02026,ko:K08715	-	M00207	-	-	ko00000,ko00002,ko02000	1.A.2.2,3.A.1.1	-	-	IRK
k59_61193_1	522306.CAP2UW1_0576	3.94e-43	155.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,1KR9D@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_61193_2	1123253.AUBD01000009_gene2274	1.53e-06	50.1	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1X3IV@135614|Xanthomonadales	135614|Xanthomonadales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_355532_1	1229909.NSED_09480	1.37e-44	156.0	COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota	2157|Archaea	P	Sodium hydrogen exchanger	napA	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
k59_908883_1	1356852.N008_06485	3.76e-28	116.0	COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,47M5P@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_877386_1	159087.Daro_0001	4.87e-20	90.1	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,2KUSQ@206389|Rhodocyclales	206389|Rhodocyclales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_649071_1	335283.Neut_1921	3.2e-42	157.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,372I1@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_775775_1	1255043.TVNIR_1860	2.29e-65	213.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_355548_1	1338011.BD94_2772	6.84e-18	85.9	COG0477@1|root,COG2814@2|Bacteria,4NE7Z@976|Bacteroidetes	976|Bacteroidetes	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_649074_1	1454004.AW11_01803	2.16e-81	249.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,1KPRN@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_908891_2	330214.NIDE1655	8.26e-33	114.0	28ZVQ@1|root,2ZMK7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_908891_3	879212.DespoDRAFT_03678	4.58e-28	108.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2WJW9@28221|Deltaproteobacteria,2MIK9@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0899	F420_oxidored,P5CR_dimer
k59_61219_1	765911.Thivi_3479	9.42e-75	239.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales	135613|Chromatiales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_538686_1	1232410.KI421422_gene2077	3.24e-57	182.0	COG1633@1|root,COG1633@2|Bacteria,1NW91@1224|Proteobacteria,4307I@68525|delta/epsilon subdivisions,2WV5S@28221|Deltaproteobacteria,43UZ5@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_775782_1	991905.SL003B_0004	1.84e-72	241.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,4BPJS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_29623_2	1348635.BBJY01000007_gene165	2.97e-24	102.0	29YUS@1|root,30KR6@2|Bacteria,1PXGV@1224|Proteobacteria,1TJ67@1236|Gammaproteobacteria,1Y0NZ@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1026418_1	272134.KB731324_gene2816	4.48e-34	131.0	COG0402@1|root,COG0402@2|Bacteria,1G427@1117|Cyanobacteria	1117|Cyanobacteria	F	cytosine deaminase	codA	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_976961_1	1267005.KB911257_gene720	9.99e-11	62.4	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,2TURK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_95348_1	1121405.dsmv_1725	2.78e-78	244.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2MIAD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1007606_1	330214.NIDE3341	3.33e-102	307.0	COG0303@1|root,COG0303@2|Bacteria,3J0MX@40117|Nitrospirae	40117|Nitrospirae	H	Probable molybdopterin binding domain	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_386914_1	1125863.JAFN01000001_gene1609	2.42e-123	366.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	ribonuclease Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_585143_1	1265502.KB905932_gene1873	1.15e-81	267.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,4A9NR@80864|Comamonadaceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_29636_1	1166018.FAES_4371	5.6e-28	110.0	COG0412@1|root,COG0412@2|Bacteria,4NEUX@976|Bacteroidetes,47JGG@768503|Cytophagia	976|Bacteroidetes	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_29636_2	1198114.AciX9_1727	1.25e-05	50.4	COG0746@1|root,COG0746@2|Bacteria,3Y5GH@57723|Acidobacteria,2JJWH@204432|Acidobacteriia	204432|Acidobacteriia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_585150_1	454957.IA64_05670	2.05e-14	67.4	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1X7QA@135614|Xanthomonadales	135614|Xanthomonadales	J	modulation protein	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_585150_2	1120999.JONM01000004_gene3526	1.59e-63	197.0	COG3045@1|root,COG3045@2|Bacteria,1RDMP@1224|Proteobacteria,2VRJ6@28216|Betaproteobacteria,2KQVD@206351|Neisseriales	206351|Neisseriales	S	CreA protein	-	-	-	ko:K05805	-	-	-	-	ko00000	-	-	-	CreA
k59_127287_1	754035.Mesau_03656	7.6e-42	155.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,2TSQU@28211|Alphaproteobacteria,43H33@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
k59_748474_1	1396141.BATP01000027_gene1185	7.61e-83	272.0	COG0458@1|root,COG0458@2|Bacteria,46SBT@74201|Verrucomicrobia,2IU2N@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_877421_1	543728.Vapar_2357	4.26e-85	274.0	COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,4AA75@80864|Comamonadaceae	28216|Betaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
k59_585151_1	864051.BurJ1DRAFT_1240	2.55e-94	300.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,1KITH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_715974_1	1121430.JMLG01000013_gene1872	1.72e-58	196.0	COG0477@1|root,COG0477@2|Bacteria,1UNMW@1239|Firmicutes,25ECT@186801|Clostridia,2607G@186807|Peptococcaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_794184_1	745014.OMB55_00007410	5.15e-73	231.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
k59_976987_2	1121939.L861_00430	1.56e-108	327.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_416535_1	1123368.AUIS01000007_gene2766	2.45e-113	332.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,2NC87@225057|Acidithiobacillales	225057|Acidithiobacillales	S	PFAM ATPase associated with various cellular activities	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_416535_2	1123368.AUIS01000007_gene2767	1.63e-29	108.0	2CJFI@1|root,32XF5@2|Bacteria,1N623@1224|Proteobacteria,1SRCG@1236|Gammaproteobacteria,2NCZV@225057|Acidithiobacillales	225057|Acidithiobacillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_519690_1	1392498.JQLH01000001_gene309	2.4e-82	265.0	COG1629@1|root,COG4771@2|Bacteria,4NF05@976|Bacteroidetes,1HYU9@117743|Flavobacteriia,2PIWF@252356|Maribacter	976|Bacteroidetes	P	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014,ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.1,1.B.14.10	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_127301_2	350688.Clos_2140	4.48e-18	87.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,36FZW@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
k59_61250_1	1384484.AEQU_0213	6.04e-28	125.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4CUED@84998|Coriobacteriia	84998|Coriobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1007639_1	396588.Tgr7_1267	2.36e-24	100.0	COG0247@1|root,COG1145@1|root,COG0247@2|Bacteria,COG1145@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1WWK6@135613|Chromatiales	135613|Chromatiales	C	PFAM Cysteine-rich	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_29661_1	338963.Pcar_1237	8.24e-108	321.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_224403_1	929713.NIASO_02040	1.53e-10	63.5	COG1595@1|root,COG1595@2|Bacteria,4NQ2T@976|Bacteroidetes	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_452532_1	410358.Mlab_0721	3.98e-09	61.2	arCOG03526@1|root,arCOG03526@2157|Archaea,2Y654@28890|Euryarchaeota,2NA7Z@224756|Methanomicrobia	224756|Methanomicrobia	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_224407_1	1120966.AUBU01000006_gene3213	1.1e-70	223.0	2AD1K@1|root,312PR@2|Bacteria,4NPRM@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_355600_1	398720.MED217_10152	9.37e-08	55.5	COG1277@1|root,COG1277@2|Bacteria,4NG5G@976|Bacteroidetes,1HX1M@117743|Flavobacteriia,2XIQS@283735|Leeuwenhoekiella	976|Bacteroidetes	S	ABC-2 family transporter protein	gldF	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_355600_2	395494.Galf_0471	5.21e-23	99.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria,44VJT@713636|Nitrosomonadales	28216|Betaproteobacteria	P	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_192022_1	859657.RPSI07_mp0507	1.5e-122	366.0	COG2082@1|root,COG2138@1|root,COG2082@2|Bacteria,COG2138@2|Bacteria,1MX1E@1224|Proteobacteria,2VNZM@28216|Betaproteobacteria,1KH48@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Precorrin-8X methylmutase	cobH	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiC,CbiX
k59_649128_1	1163617.SCD_n00733	9.95e-32	124.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2WHEI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_253254_1	1366050.N234_29405	5.65e-19	90.9	COG2159@1|root,COG2159@2|Bacteria,1N4SA@1224|Proteobacteria,2W2QV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_159944_2	82996.sch_22275	3.91e-66	214.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,4012V@613|Serratia	1236|Gammaproteobacteria	L	Adenine glycosylase	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_616855_1	887062.HGR_04433	3.97e-10	60.8	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VK35@28216|Betaproteobacteria,4AA1P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	soxF	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
k59_616855_2	156889.Mmc1_2995	1.12e-14	74.3	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,2TSFV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_616855_3	1266925.JHVX01000012_gene1687	1.76e-87	278.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,372BV@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_386951_1	1500897.JQNA01000002_gene4188	2.3e-32	127.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI09@28216|Betaproteobacteria,1K342@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_320698_1	436308.Nmar_0095	1.65e-28	109.0	COG0576@1|root,arCOG04772@2157|Archaea,41SSU@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_585188_1	522306.CAP2UW1_3158	8.95e-11	63.5	COG2801@1|root,COG2801@2|Bacteria,1MUSB@1224|Proteobacteria,2VP7Z@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,HTH_Tnp_Mu_1,Mu-transpos_C,rve
k59_585188_2	338966.Ppro_1321	1.34e-65	211.0	COG3267@1|root,COG3267@2|Bacteria,1Q4DA@1224|Proteobacteria,42YYB@68525|delta/epsilon subdivisions,2WU9J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_944206_1	1382356.JQMP01000003_gene1476	8.17e-53	187.0	COG1529@1|root,COG1529@2|Bacteria,2GBUE@200795|Chloroflexi,27Z0K@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_944206_2	1382356.JQMP01000003_gene1475	4.28e-66	207.0	COG1878@1|root,COG1878@2|Bacteria,2GBDZ@200795|Chloroflexi,27Z1S@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_355614_1	1160721.RBI_I01680	3.15e-07	53.9	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,247R1@186801|Clostridia	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain protein	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_355614_2	1500893.JQNB01000001_gene1323	7.45e-12	64.7	COG3153@1|root,COG3153@2|Bacteria,1RA42@1224|Proteobacteria,1S2G0@1236|Gammaproteobacteria,1X6YM@135614|Xanthomonadales	135614|Xanthomonadales	S	acetyltransferase	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_9
k59_159953_1	472759.Nhal_2115	2.66e-54	176.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_519718_1	323261.Noc_2921	5.83e-88	274.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_61286_1	1149133.ppKF707_2583	1.8e-21	94.7	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,1RQIV@1236|Gammaproteobacteria,1YEJ8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Protein of unknown function (DUF3300)	yacH	-	-	-	-	-	-	-	-	-	-	-	DUF3300
k59_61286_2	566466.NOR53_2962	6.43e-27	104.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_716752_2	338963.Pcar_3335	2.27e-17	74.7	2DFXN@1|root,2ZTM4@2|Bacteria,1PAHN@1224|Proteobacteria,433NA@68525|delta/epsilon subdivisions,2WXDY@28221|Deltaproteobacteria,43VTW@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_716752_3	1232410.KI421424_gene1582	0.000104	43.5	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1N3ZM@1224|Proteobacteria,42TUU@68525|delta/epsilon subdivisions,2WQ8Z@28221|Deltaproteobacteria,43TAJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	KP	PFAM iron dependent repressor	ideR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
k59_909649_1	690850.Desaf_1298	2.34e-29	116.0	28IBE@1|root,2Z8DX@2|Bacteria,1NC7D@1224|Proteobacteria,42RTW@68525|delta/epsilon subdivisions,2WV2Q@28221|Deltaproteobacteria,2MAKZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative amidoligase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Amidoligase_2
k59_520472_1	768671.ThimaDRAFT_0873	2.91e-86	271.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales	135613|Chromatiales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_520472_2	1121875.KB907546_gene2198	3.13e-16	79.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_281734_1	1121403.AUCV01000024_gene3450	5.27e-55	194.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WKJV@28221|Deltaproteobacteria,2MPX6@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,PA14
k59_749308_1	261292.Nit79A3_0016	1.77e-121	369.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,371ZZ@32003|Nitrosomonadales	28216|Betaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_2,Thioredoxin_7
k59_392992_1	1089550.ATTH01000001_gene1141	2.17e-17	87.4	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FK0T@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_654416_1	1269813.ATUL01000016_gene55	1.28e-68	215.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1WWWY@135613|Chromatiales	135613|Chromatiales	D	Belongs to the TtcA family	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_752019_1	1382306.JNIM01000001_gene117	4.8e-25	105.0	COG0095@1|root,COG0095@2|Bacteria,2G6P9@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_523751_1	1095769.CAHF01000022_gene341	6.75e-108	350.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VJEX@28216|Betaproteobacteria,476HV@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Neisseria PilC beta-propeller domain	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_66699_1	1173020.Cha6605_2468	1.84e-14	72.4	COG1004@1|root,COG1004@2|Bacteria,1G1GI@1117|Cyanobacteria	1117|Cyanobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_360327_1	713586.KB900536_gene793	7.1e-79	248.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WVX4@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_360328_2	391615.ABSJ01000004_gene637	2.79e-47	163.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1J5S7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	opsX	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_425685_1	945713.IALB_1579	1.11e-83	261.0	COG0034@1|root,COG0034@2|Bacteria	2|Bacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iSB619.SA_RS05225	GATase_6,GATase_7,Pribosyltran
k59_164591_1	305700.B447_06592	1.64e-13	65.9	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VTFS@28216|Betaproteobacteria,2KWUC@206389|Rhodocyclales	206389|Rhodocyclales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_164591_2	1298864.AUEQ01000023_gene1375	7.55e-54	175.0	COG1028@1|root,COG1028@2|Bacteria,2GJW1@201174|Actinobacteria,232H3@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Dehydrogenase	-	-	1.1.1.100	ko:K00059,ko:K07535	ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220	M00083,M00540,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117,RC00154	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1312_2	1337093.MBE-LCI_0864	3.4e-49	171.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TQXH@28211|Alphaproteobacteria,2P9MR@245186|Loktanella	28211|Alphaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_327806_15	290317.Cpha266_2670	1.04e-07	60.1	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.38	ko:K01371	ko04142,ko04210,ko04380,ko04620,ko05323,map04142,map04210,map04380,map04620,map05323	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_C1
k59_327806_20	1005058.UMN179_02384	2.51e-40	138.0	COG3108@1|root,COG3108@2|Bacteria,1RICX@1224|Proteobacteria,1S6D5@1236|Gammaproteobacteria,1YAB3@135625|Pasteurellales	135625|Pasteurellales	S	D-alanyl-D-alanine carboxypeptidase	-	-	-	ko:K17733	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M15_4
k59_99317_1	926569.ANT_06710	6.11e-65	218.0	COG1178@1|root,COG1178@2|Bacteria,2G63A@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	BPD_transp_1
k59_262623_1	1002340.AFCF01000029_gene3378	5.18e-23	102.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_132006_1	768671.ThimaDRAFT_0868	2.66e-29	111.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1S1PR@1236|Gammaproteobacteria,1WY6G@135613|Chromatiales	135613|Chromatiales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_132006_2	768671.ThimaDRAFT_0869	3.97e-62	202.0	COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,1S8EQ@1236|Gammaproteobacteria,1WYKW@135613|Chromatiales	135613|Chromatiales	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_687076_1	1198452.Jab_2c01520	1.83e-130	394.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4736W@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
k59_393029_1	857087.Metme_3500	2.22e-76	234.0	COG0625@1|root,COG0625@2|Bacteria,1MWY4@1224|Proteobacteria,1RXVJ@1236|Gammaproteobacteria,1XFNQ@135618|Methylococcales	135618|Methylococcales	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N_3
k59_980736_1	1049564.TevJSym_bc00360	1.71e-84	259.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1JB7M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_66737_1	243365.CV_1129	1.57e-05	46.6	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,2KQ8E@206351|Neisseriales	206351|Neisseriales	I	Psort location Cytoplasmic, score 8.96	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_66737_2	1000565.METUNv1_02924	5.96e-41	139.0	COG3807@1|root,COG3807@2|Bacteria,1MZIA@1224|Proteobacteria,2VUTD@28216|Betaproteobacteria,2KWXG@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_4
k59_327817_1	946483.Cenrod_0945	1.7e-31	122.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,4A9YY@80864|Comamonadaceae	28216|Betaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_654467_1	247633.GP2143_09040	1.87e-65	225.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J8T8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_948158_1	882378.RBRH_03207	4.82e-19	83.2	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,1K5S0@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_850125_2	1454004.AW11_01469	4.79e-17	76.6	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,1KQR7@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_360367_1	1173027.Mic7113_4893	3.46e-49	178.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7T9@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_99334_1	1194972.MVAC_11072	4.1e-75	238.0	2DB85@1|root,2Z7Q2@2|Bacteria,2GTBY@201174|Actinobacteria,232HI@1762|Mycobacteriaceae	201174|Actinobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_295195_1	1168289.AJKI01000040_gene3206	6.54e-09	60.1	COG3385@1|root,COG3385@2|Bacteria,4NG39@976|Bacteroidetes	976|Bacteroidetes	L	Pfam Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_425737_1	1288494.EBAPG3_24400	1.78e-91	283.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,37277@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_425737_2	1288494.EBAPG3_24390	2.11e-09	56.6	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,372PR@32003|Nitrosomonadales	28216|Betaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
k59_132039_1	1499967.BAYZ01000080_gene921	3.5e-63	201.0	COG1432@1|root,COG1432@2|Bacteria	2|Bacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_523812_1	1121403.AUCV01000004_gene2045	2.67e-33	125.0	29J9T@1|root,3067A@2|Bacteria,1RE8D@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2860)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2860
k59_523812_2	246194.CHY_0372	1.61e-06	48.1	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	3.1.3.3	ko:K07315,ko:K17763	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,STAS
k59_459097_2	396595.TK90_0340	2.25e-21	93.6	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1WXFU@135613|Chromatiales	135613|Chromatiales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_557479_1	1163617.SCD_n01883	1.41e-177	519.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,2WEVG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_557479_2	1469245.JFBG01000019_gene1131	1.04e-33	128.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,1RYIC@1236|Gammaproteobacteria,1WY81@135613|Chromatiales	135613|Chromatiales	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored
k59_981514_1	1100720.ALKN01000040_gene2164	1.54e-29	112.0	COG0411@1|root,COG0411@2|Bacteria,1MVAU@1224|Proteobacteria,2VP5B@28216|Betaproteobacteria,4AAZV@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_981514_2	887062.HGR_05314	5.71e-70	219.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VM1A@28216|Betaproteobacteria,4ACV1@80864|Comamonadaceae	28216|Betaproteobacteria	E	AAA domain	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_818704_1	555088.DealDRAFT_0814	2.84e-07	52.8	COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia	186801|Clostridia	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_655405_1	944480.ATUV01000001_gene752	6.12e-11	61.6	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2M6R5@213113|Desulfurellales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_655405_2	760568.Desku_1900	1e-19	89.7	COG0697@1|root,COG0697@2|Bacteria,1TR6G@1239|Firmicutes,24AMC@186801|Clostridia,262QM@186807|Peptococcaceae	186801|Clostridia	EG	PFAM EamA-like transporter family	yicL	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_2249_1	56780.SYN_02106	4.36e-19	83.6	2ED7H@1|root,33743@2|Bacteria,1QB7X@1224|Proteobacteria,42ZXA@68525|delta/epsilon subdivisions,2WVEQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_2249_2	243231.GSU0233	3.03e-26	102.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,42S8C@68525|delta/epsilon subdivisions,2WP10@28221|Deltaproteobacteria,43TU3@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF480	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
k59_492212_1	765911.Thivi_1901	2.72e-69	225.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WWF8@135613|Chromatiales	135613|Chromatiales	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_296037_1	1038859.AXAU01000003_gene5960	1.28e-15	74.3	2F35P@1|root,33W0B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_296037_2	266265.Bxe_A2877	3.81e-05	46.6	COG4319@1|root,COG4319@2|Bacteria,1PIJU@1224|Proteobacteria,2W76D@28216|Betaproteobacteria,1KDXK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_720601_1	278957.ABEA03000173_gene2411	1.93e-61	217.0	28I8X@1|root,2Z8BQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_230635_1	696281.Desru_2671	1.81e-47	171.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,26021@186807|Peptococcaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4
k59_67766_1	76114.ebA2940	6.11e-86	277.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,2KVUW@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
k59_2269_1	1216976.AX27061_4360	2.19e-08	54.3	COG0810@1|root,COG0810@2|Bacteria,1MZQW@1224|Proteobacteria,2VU0N@28216|Betaproteobacteria,3T4FY@506|Alcaligenaceae	28216|Betaproteobacteria	M	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
k59_2269_2	1266914.ATUK01000013_gene1768	2.1e-28	113.0	COG0834@1|root,COG0834@2|Bacteria,1RH2S@1224|Proteobacteria,1S5X9@1236|Gammaproteobacteria,1X11K@135613|Chromatiales	135613|Chromatiales	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_622684_1	1121035.AUCH01000008_gene1003	1.88e-55	181.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,2KWGK@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_459126_1	1158612.I580_00833	5.64e-69	219.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,4B1B0@81852|Enterococcaceae	91061|Bacilli	C	Transketolase, pyrimidine binding domain	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_230647_1	977880.RALTA_A1335	3.26e-76	241.0	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,1QYHB@1224|Proteobacteria,2W1S8@28216|Betaproteobacteria,1K5IY@119060|Burkholderiaceae	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE
k59_67775_2	323848.Nmul_A0582	1.28e-24	99.8	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2VI10@28216|Betaproteobacteria,3726W@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_296055_2	56780.SYN_01247	1.02e-31	113.0	2DCXT@1|root,2ZFR8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_818749_2	1304284.L21TH_2302	2.07e-14	74.3	COG2206@1|root,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,25EWN@186801|Clostridia,36USS@31979|Clostridiaceae	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GAF_2,HAMP,HD,HD_5,Reg_prop,Response_reg,Y_Y_Y,dCache_1
k59_209389_2	765911.Thivi_3550	8.12e-33	121.0	COG0664@1|root,COG0664@2|Bacteria,1RD80@1224|Proteobacteria,1S4Q2@1236|Gammaproteobacteria,1WY7A@135613|Chromatiales	135613|Chromatiales	T	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_209389_3	1123257.AUFV01000001_gene1577	5.06e-101	301.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,1S2MJ@1236|Gammaproteobacteria,1X6B4@135614|Xanthomonadales	135614|Xanthomonadales	S	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_209389_4	1304883.KI912532_gene2434	4.06e-74	230.0	COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,2VN74@28216|Betaproteobacteria,2KUVC@206389|Rhodocyclales	206389|Rhodocyclales	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_468332_1	933262.AXAM01000040_gene1232	9.83e-92	293.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_403151_1	375286.mma_2403	9.21e-84	271.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,472FR@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_531047_1	338963.Pcar_1361	2.01e-106	322.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,43RZT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
k59_700009_1	323848.Nmul_A0759	7.27e-80	265.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,37253@32003|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_372344_1	234267.Acid_1441	1.51e-53	183.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_144519_1	517433.PanABDRAFT_0326	2.34e-16	85.1	COG0515@1|root,COG2041@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2041@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,3VY7P@53335|Pantoea	1236|Gammaproteobacteria	T	serine threonine protein kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,HATPase_c,HisKA,MASE1,PAS_3,PAS_4,PAS_9,Pkinase
k59_177102_1	1206731.BAGB01000023_gene1226	4.19e-06	54.3	COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria,4FVPU@85025|Nocardiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_209418_1	335543.Sfum_1045	2.05e-29	115.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria,2MRAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_14179_1	1417296.U879_08035	2.87e-40	147.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_830523_1	485918.Cpin_6848	5.22e-38	138.0	COG4990@1|root,COG4990@2|Bacteria,4NFZX@976|Bacteroidetes,1IPPX@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4872)	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
k59_894293_1	1123367.C666_17250	1.23e-61	207.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2VHR9@28216|Betaproteobacteria,2KU7B@206389|Rhodocyclales	206389|Rhodocyclales	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_79507_1	177437.HRM2_13220	4.3e-70	233.0	COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0456@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2MK5E@213118|Desulfobacterales	28221|Deltaproteobacteria	BKQ	Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
k59_372375_1	1163617.SCD_n01884	4.37e-40	143.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,2VUBQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Glucose inhibited division protein A	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored
k59_1018778_1	485913.Krac_5271	2.9e-32	124.0	COG1914@1|root,COG1914@2|Bacteria,2G67K@200795|Chloroflexi	200795|Chloroflexi	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
k59_894299_1	927658.AJUM01000022_gene1031	1.62e-109	323.0	COG0524@1|root,COG0524@2|Bacteria,4NH8K@976|Bacteroidetes,2FM8P@200643|Bacteroidia,3XIZT@558415|Marinilabiliaceae	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_894299_2	886379.AEWI01000001_gene1807	3.28e-19	86.7	COG3875@1|root,COG3875@2|Bacteria,4NI4Z@976|Bacteroidetes,2FQM8@200643|Bacteroidia,3XJV1@558415|Marinilabiliaceae	976|Bacteroidetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_46466_1	393283.XP_007835950.1	7.13e-09	63.2	COG3509@1|root,2SBTI@2759|Eukaryota,39SMX@33154|Opisthokonta,3NZNX@4751|Fungi,3QMGM@4890|Ascomycota,218D8@147550|Sordariomycetes	4751|Fungi	Q	ferulic acid esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
k59_633917_1	1122963.AUHB01000012_gene1190	2.38e-28	121.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,36YDD@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	MlaD protein	MA20_08125	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_209441_1	452637.Oter_3564	1.14e-47	167.0	COG2518@1|root,COG2518@2|Bacteria,46UEK@74201|Verrucomicrobia,3K7SY@414999|Opitutae	414999|Opitutae	O	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_32
k59_209442_1	981383.AEWH01000059_gene2118	9.54e-15	73.2	COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,4HA1G@91061|Bacilli	91061|Bacilli	G	COG0366 Glycosidases	malL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_209442_2	1173027.Mic7113_3750	6.46e-44	160.0	COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,1G0DN@1117|Cyanobacteria,1HA78@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
k59_14205_1	1123376.AUIU01000012_gene1437	2.41e-94	304.0	COG0458@1|root,COG0458@2|Bacteria,3J0BC@40117|Nitrospirae	40117|Nitrospirae	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_732435_1	452637.Oter_1728	3.23e-43	157.0	COG0642@1|root,COG2205@2|Bacteria,46TKR@74201|Verrucomicrobia,3K7YS@414999|Opitutae	452637.Oter_1728|-	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_14207_1	1254432.SCE1572_35590	8.83e-15	68.9	COG0662@1|root,COG0662@2|Bacteria,1N7Q4@1224|Proteobacteria	1224|Proteobacteria	G	Ethanolamine utilisation protein EutQ	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_862162_1	1301098.PKB_1761	9.01e-16	72.4	COG2149@1|root,COG2149@2|Bacteria,1N173@1224|Proteobacteria,1SC54@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
k59_862162_2	1131553.JIBI01000014_gene858	5.23e-64	199.0	2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,2VSTN@28216|Betaproteobacteria,37352@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1841)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1841
k59_569202_1	477184.KYC_09120	3.28e-103	329.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,3T1UC@506|Alcaligenaceae	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_668243_1	159087.Daro_2976	4.8e-20	81.3	COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,2VXNJ@28216|Betaproteobacteria,2KX7Z@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
k59_668243_2	85643.Tmz1t_3382	9.55e-97	290.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,2KUAU@206389|Rhodocyclales	206389|Rhodocyclales	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_831558_1	1116472.MGMO_45c00160	1.98e-55	186.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1XE9X@135618|Methylococcales	135618|Methylococcales	G	PFAM Carbohydrate purine kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_373274_1	1005048.CFU_3479	1.32e-99	309.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,4733B@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_602468_1	509635.N824_05670	2.88e-15	80.5	COG1262@1|root,COG1262@2|Bacteria,4NEUZ@976|Bacteroidetes	976|Bacteroidetes	KLT	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT,FGE-sulfatase
k59_863077_1	290315.Clim_2386	5.89e-32	117.0	2C8DW@1|root,32RKY@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF3597)	MA20_41375	-	-	-	-	-	-	-	-	-	-	-	DUF3597
k59_341153_1	1121405.dsmv_1069	5.05e-84	254.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,42N6T@68525|delta/epsilon subdivisions,2WMKR@28221|Deltaproteobacteria,2MIW9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
k59_831566_1	330214.NIDE0989	1.51e-53	183.0	COG0358@1|root,COG0358@2|Bacteria,3J0IN@40117|Nitrospirae	40117|Nitrospirae	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4,Toprim_N,zf-CHC2
k59_831566_2	211165.AJLN01000057_gene2877	3.82e-45	149.0	COG0537@1|root,COG0537@2|Bacteria,1G6R2@1117|Cyanobacteria,1JITE@1189|Stigonemataceae	1117|Cyanobacteria	FG	HIT domain	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
k59_438565_1	313628.LNTAR_24990	4.22e-34	132.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_961920_1	1469245.JFBG01000016_gene965	2.36e-05	46.2	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X0T0@135613|Chromatiales	135613|Chromatiales	O	PFAM Cytochrome c oxidase assembly protein CtaG Cox11	-	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_961920_2	1335757.SPICUR_01585	4.27e-50	172.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_178066_1	95619.PM1_0219980	1.92e-33	128.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Lytic murein transglycosylase	-	-	5.1.3.15	ko:K01792,ko:K08305	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000,ko01011	-	GH103	-	Aldose_epim,PG_binding_1,SLT_2
k59_668252_1	522306.CAP2UW1_0940	1.97e-13	74.3	COG0666@1|root,COG0666@2|Bacteria,1R76J@1224|Proteobacteria,2VP42@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_4
k59_929351_1	1231391.AMZF01000003_gene3182	2.62e-110	325.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2WG6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_438578_1	396588.Tgr7_0573	1.76e-33	125.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales	135613|Chromatiales	E	Belongs to the peptidase M20A family. ArgE subfamily	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_961943_1	331678.Cphamn1_0608	7.88e-27	108.0	COG0205@1|root,COG0205@2|Bacteria,1FEH2@1090|Chlorobi	1090|Chlorobi	G	PFAM phosphofructokinase	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_47388_1	1169143.KB911050_gene2782	2e-15	76.3	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,1K0DB@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_929355_1	497964.CfE428DRAFT_3339	3.73e-71	225.0	COG0682@1|root,COG0682@2|Bacteria,46SSY@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_993621_1	1121937.AUHJ01000006_gene2459	7.5e-91	276.0	COG2141@1|root,COG2141@2|Bacteria,1MWI8@1224|Proteobacteria,1S10Y@1236|Gammaproteobacteria,468VQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_762980_1	1191523.MROS_1879	1.65e-29	115.0	COG1043@1|root,COG1043@2|Bacteria	2|Bacteria	M	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_570199_1	1367847.JCM7686_1167	9.63e-15	79.3	COG0451@1|root,COG0451@2|Bacteria,1P603@1224|Proteobacteria,2U9VR@28211|Alphaproteobacteria,2PWRA@265|Paracoccus	28211|Alphaproteobacteria	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_15171_1	414684.RC1_2673	8.5e-66	208.0	2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,2U7X0@28211|Alphaproteobacteria,2JSDR@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF2889)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2889
k59_15171_2	1149133.ppKF707_5636	1.63e-45	157.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,1RMUX@1236|Gammaproteobacteria,1YE3W@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA	mvaB	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_341181_1	82654.Pse7367_1934	4.62e-38	139.0	COG0719@1|root,COG0719@2|Bacteria,1G0TH@1117|Cyanobacteria,1H8CG@1150|Oscillatoriales	1117|Cyanobacteria	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_341181_2	338969.Rfer_1859	1.85e-41	139.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSKY@28216|Betaproteobacteria,4ADXX@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the HesB IscA family	iscA	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_341181_3	1288494.EBAPG3_600	1.72e-156	452.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,371RC@32003|Nitrosomonadales	28216|Betaproteobacteria	E	PFAM Aminotransferase, class V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_341181_4	1288494.EBAPG3_350	1.68e-05	46.6	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,3732A@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Transcriptional regulator	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_668294_1	243090.RB12556	1.66e-79	249.0	COG0715@1|root,COG0715@2|Bacteria,2J07J@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
k59_438600_1	1121035.AUCH01000008_gene1027	5.57e-19	86.7	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,2KUP7@206389|Rhodocyclales	206389|Rhodocyclales	LU	Rossmann fold nucleotide-binding protein involved in DNA uptake	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_438600_2	1163617.SCD_n00008	3.2e-23	97.4	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_531579_1	1265502.KB905941_gene2892	3.32e-80	249.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,4ABQ0@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_341189_2	1150626.PHAMO_80072	5.57e-21	97.8	COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2TV42@28211|Alphaproteobacteria,2JXEM@204441|Rhodospirillales	204441|Rhodospirillales	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_762999_1	1183438.GKIL_3395	8.17e-61	209.0	COG0515@1|root,COG0515@2|Bacteria,1G3GV@1117|Cyanobacteria	1183438.GKIL_3395|-	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
k59_504950_1	471852.Tcur_3788	3.34e-34	122.0	COG2905@1|root,COG2905@2|Bacteria,2I3M3@201174|Actinobacteria,4EQ3E@85012|Streptosporangiales	201174|Actinobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_504960_1	439235.Dalk_5087	2.78e-52	177.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_895291_1	330214.NIDE0577	9.7e-47	167.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
k59_895291_2	1267535.KB906767_gene2456	1.04e-09	60.5	COG1752@1|root,COG1752@2|Bacteria,3Y6DZ@57723|Acidobacteria,2JMMY@204432|Acidobacteriia	204432|Acidobacteriia	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_504961_1	1123368.AUIS01000018_gene729	1.84e-66	218.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,2NC1Z@225057|Acidithiobacillales	225057|Acidithiobacillales	P	major facilitator superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
k59_961998_1	1288494.EBAPG3_25380	6.74e-16	77.8	COG3147@1|root,COG3147@2|Bacteria,1R7IV@1224|Proteobacteria,2VPE1@28216|Betaproteobacteria,373EA@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Sporulation related domain	dedD	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
k59_961998_2	1095769.CAHF01000011_gene2542	1.33e-26	105.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2VUM6@28216|Betaproteobacteria,4743C@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	colicin V production	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
k59_961998_3	1120999.JONM01000003_gene2708	9.46e-60	198.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,2KQ0E@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_678975_2	977880.RALTA_B0210	2.78e-82	259.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6UF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_873363_1	1158050.KB895464_gene3654	8.65e-05	46.6	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,1W8PS@1268|Micrococcaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_873363_2	1232683.ADIMK_2107	4.05e-26	109.0	COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,1RS0H@1236|Gammaproteobacteria,46AHH@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	AMP-binding enzyme	fcs	-	6.2.1.34	ko:K12508	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
k59_873371_2	330214.NIDE3074	7.19e-65	210.0	COG0541@1|root,COG0541@2|Bacteria,3J0DT@40117|Nitrospirae	40117|Nitrospirae	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_904995_1	1121405.dsmv_0689	7.44e-95	282.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42R03@68525|delta/epsilon subdivisions,2WMTZ@28221|Deltaproteobacteria,2MJ7X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_904995_2	439235.Dalk_2567	1.65e-05	47.0	COG3829@1|root,COG4191@1|root,COG4585@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria,1RCM9@1224|Proteobacteria,43CS1@68525|delta/epsilon subdivisions,2X7ZN@28221|Deltaproteobacteria,2MPMC@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,dCache_1
k59_972667_1	1218084.BBJK01000007_gene1100	3.07e-92	284.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1JZMS@119060|Burkholderiaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_477998_1	1288494.EBAPG3_18020	6.17e-41	152.0	COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,2VKXR@28216|Betaproteobacteria,372NR@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_645127_1	1123072.AUDH01000002_gene2274	2.69e-50	172.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2TZJ8@28211|Alphaproteobacteria,2JUBE@204441|Rhodospirillales	204441|Rhodospirillales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_449413_1	1206741.BAFX01000050_gene2291	4.09e-59	191.0	COG4221@1|root,COG4221@2|Bacteria,2I7UD@201174|Actinobacteria,4G6I1@85025|Nocardiaceae	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_352313_1	1163617.SCD_n01725	1.6e-88	271.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VR2T@28216|Betaproteobacteria	28216|Betaproteobacteria	H	PUA-like domain	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PK,PUA_2
k59_973562_1	335283.Neut_2096	1.26e-33	121.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,371Y4@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_973562_2	1123392.AQWL01000005_gene2967	1.62e-59	186.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,1KT3H@119069|Hydrogenophilales	119069|Hydrogenophilales	P	ApaG domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF525
k59_679928_1	1397666.RS24_00220	2.44e-24	98.6	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,4BPYJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_613637_1	330214.NIDE1289	1.28e-90	286.0	COG0058@1|root,COG0058@2|Bacteria,3J0W1@40117|Nitrospirae	40117|Nitrospirae	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_221313_1	1304275.C41B8_03706	5.52e-33	131.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,1RSCN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
k59_449424_1	261292.Nit79A3_2023	3.79e-53	173.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2VQ83@28216|Betaproteobacteria,371PF@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Scaffold protein Nfu/NifU N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
k59_449424_2	1469245.JFBG01000025_gene1555	2.1e-10	57.4	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1S6B0@1236|Gammaproteobacteria,1WYPJ@135613|Chromatiales	135613|Chromatiales	P	PFAM Rieske 2Fe-2S	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
k59_478733_1	99598.Cal7507_3978	2.53e-14	70.1	COG1028@1|root,COG1028@2|Bacteria,1GQKG@1117|Cyanobacteria,1HTR6@1161|Nostocales	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_478733_2	546271.Selsp_0088	6.16e-39	147.0	COG2831@1|root,COG2831@2|Bacteria,1TR8V@1239|Firmicutes,4H1Z0@909932|Negativicutes	909932|Negativicutes	U	POTRA domain protein, ShlB-type	-	-	-	-	-	-	-	-	-	-	-	-	POTRA_2,ShlB
k59_940896_1	395495.Lcho_2150	9.02e-168	479.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria,1KK3S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_352327_1	1234364.AMSF01000058_gene928	2.23e-51	170.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1SYJN@1236|Gammaproteobacteria,1X5ND@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_352327_2	1267535.KB906767_gene4842	2.39e-06	52.4	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_449434_1	84531.JMTZ01000006_gene3494	1.62e-05	48.9	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1X306@135614|Xanthomonadales	135614|Xanthomonadales	MU	TIGRFAM type I secretion outer membrane protein, TolC family	raxC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_449434_2	1469245.JFBG01000075_gene163	2.52e-14	70.9	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,1WX4D@135613|Chromatiales	135613|Chromatiales	O	PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_613652_1	1121456.ATVA01000011_gene1781	0.000665	46.6	COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2M7R7@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_58143_1	517417.Cpar_0803	2.02e-16	80.9	COG2885@1|root,COG2885@2|Bacteria,1FE7F@1090|Chlorobi	1090|Chlorobi	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
k59_413827_1	1380355.JNIJ01000033_gene4221	1.95e-36	128.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,3JYFM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_413827_2	743721.Psesu_1267	4.38e-10	60.8	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1X4P1@135614|Xanthomonadales	135614|Xanthomonadales	O	Cytochrome C biogenesis	ccmF2	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_940911_1	1232437.KL661978_gene3783	2.99e-54	186.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MI8R@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_124073_1	481448.Minf_2223	3.84e-61	194.0	COG2010@1|root,COG2010@2|Bacteria,46WD1@74201|Verrucomicrobia,37GQ1@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_221332_1	565034.BHWA1_00646	3.13e-17	86.7	COG0841@1|root,COG0841@2|Bacteria,2J9MF@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_581790_1	330214.NIDE1725	1.16e-10	66.6	COG4447@1|root,COG4447@2|Bacteria,3J16A@40117|Nitrospirae	40117|Nitrospirae	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
k59_874292_1	1163617.SCD_n00279	9.14e-102	326.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria	28216|Betaproteobacteria	C	FAD linked oxidase domain protein	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_905882_1	945713.IALB_0913	9.05e-22	91.3	COG0088@1|root,COG0088@2|Bacteria	2|Bacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030312,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02926,ko:K16193	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_905882_2	945713.IALB_0914	9.66e-50	159.0	COG0089@1|root,COG0089@2|Bacteria	2|Bacteria	J	rRNA binding	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_773061_1	945713.IALB_0243	1.56e-115	343.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_478748_1	1121127.JAFA01000031_gene4654	1.15e-46	162.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VJ40@28216|Betaproteobacteria,1K4VW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_646020_1	573061.Clocel_1834	9.42e-12	64.7	COG0735@1|root,COG0735@2|Bacteria,1V7F0@1239|Firmicutes,24JQE@186801|Clostridia,36I3W@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_843323_1	1249627.D779_1513	8.88e-30	116.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
k59_843323_2	90814.KL370891_gene622	2.27e-07	53.9	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,461PB@72273|Thiotrichales	72273|Thiotrichales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_9
k59_712707_1	1122963.AUHB01000007_gene3675	2.42e-85	260.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,36XKV@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Carboxyl transferase domain	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_793032_2	1223410.KN050846_gene466	1.22e-10	62.8	COG2062@1|root,COG2062@2|Bacteria,4NQFM@976|Bacteroidetes,1I2V8@117743|Flavobacteriia	976|Bacteroidetes	T	phosphohistidine phosphatase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_413840_1	112098.XP_008615047.1	1.03e-62	206.0	COG1960@1|root,KOG0141@2759|Eukaryota	2759|Eukaryota	I	isovaleryl-CoA dehydrogenase activity	IVD	GO:0000166,GO:0003674,GO:0003824,GO:0003853,GO:0003995,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006139,GO:0006163,GO:0006195,GO:0006520,GO:0006551,GO:0006552,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008470,GO:0009056,GO:0009058,GO:0009062,GO:0009063,GO:0009081,GO:0009083,GO:0009109,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0018130,GO:0019395,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033539,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034440,GO:0034641,GO:0034654,GO:0034655,GO:0035337,GO:0035383,GO:0035639,GO:0036094,GO:0036115,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0051259,GO:0051260,GO:0055086,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0072521,GO:0072523,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901568,GO:1901569,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902189,GO:1902190,GO:1902192,GO:1902195,GO:1902196,GO:1902198	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_188835_1	398527.Bphyt_4084	2.19e-47	172.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1K035@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig
k59_383934_1	926569.ANT_27120	3.8e-102	321.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N
k59_156812_2	439235.Dalk_0117	7.64e-83	259.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2MJ7G@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
k59_156814_1	7227.FBpp0100180	5.25e-70	219.0	COG1845@1|root,KOG4664@2759|Eukaryota,39ASV@33154|Opisthokonta,3BF9J@33208|Metazoa,3CUZX@33213|Bilateria,420NY@6656|Arthropoda,3SM4Z@50557|Insecta,44XZ9@7147|Diptera	33208|Metazoa	C	Subunits I, II and III form the functional core of the enzyme complex	COX3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0008150,GO:0008535,GO:0009987,GO:0016020,GO:0016043,GO:0017004,GO:0019866,GO:0022607,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034622,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045277,GO:0065003,GO:0070069,GO:0070469,GO:0071840,GO:0098796,GO:0098803	-	ko:K02262	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX3
k59_26487_1	748247.AZKH_p0053	1.25e-134	405.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_773078_1	28152.DJ57_1603	2.63e-25	98.2	2E1B7@1|root,32WR3@2|Bacteria,1N4JM@1224|Proteobacteria,1TDIP@1236|Gammaproteobacteria,41G9H@629|Yersinia	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_773078_2	312153.Pnuc_0342	4.55e-16	73.2	COG4742@1|root,COG4742@2|Bacteria	2|Bacteria	K	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,HATPase_c,Methyltransf_2,Response_reg
k59_58170_1	497964.CfE428DRAFT_3132	2.66e-47	172.0	COG3852@1|root,COG5000@1|root,COG3852@2|Bacteria,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_188847_1	1454004.AW11_00117	2.13e-46	158.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2VQQD@28216|Betaproteobacteria	1224|Proteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF2064,Glyco_tranf_2_3,Glycos_transf_2
k59_156816_1	472175.EL18_02586	1.06e-126	371.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,43HCS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	MA20_14330	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_679980_1	373903.Hore_06260	5.01e-88	273.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,3WA7W@53433|Halanaerobiales	186801|Clostridia	I	Carbamoyl-phosphate synthase L chain, ATP binding domain	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_413853_1	420662.Mpe_A0770	7.74e-85	258.0	COG1802@1|root,COG1802@2|Bacteria,1MW9G@1224|Proteobacteria,2VQ9U@28216|Betaproteobacteria,1KKKQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	GntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_124106_1	458817.Shal_3258	7.24e-31	127.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,2Q9TR@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM peptidase M13, neprilysin	pepO	-	3.4.24.71	ko:K01415,ko:K07386	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_537103_1	1042326.AZNV01000006_gene4499	6.97e-98	306.0	COG4302@1|root,COG4303@1|root,COG4302@2|Bacteria,COG4303@2|Bacteria,1MUR4@1224|Proteobacteria,2U3B1@28211|Alphaproteobacteria,4BMZK@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Ethanolamine ammonia lyase large subunit (EutB)	-	-	4.3.1.7	ko:K03735	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutB,EutC
k59_773093_1	511.JT27_14545	3.1e-75	239.0	COG0683@1|root,COG0683@2|Bacteria,1MVZR@1224|Proteobacteria,2VIS7@28216|Betaproteobacteria,3T1IR@506|Alcaligenaceae	28216|Betaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_874339_2	1089553.Tph_c00820	4.75e-17	79.0	COG2445@1|root,COG2445@2|Bacteria,1VF8K@1239|Firmicutes,24QTN@186801|Clostridia,42J39@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
k59_221386_1	330214.NIDE3513	1.64e-107	318.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_940975_1	153948.NAL212_1439	3.37e-34	124.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VKGA@28216|Betaproteobacteria,374KV@32003|Nitrosomonadales	28216|Betaproteobacteria	V	SMART ATPase, AAA type, core	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_449502_1	926569.ANT_27540	6.08e-22	95.1	COG0460@1|root,COG0460@2|Bacteria,2G6PU@200795|Chloroflexi	200795|Chloroflexi	E	homoserine dehydrogenase	metM	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_26529_1	903818.KI912269_gene480	1.6e-16	79.7	COG4972@1|root,COG4972@2|Bacteria,3Y804@57723|Acidobacteria	57723|Acidobacteria	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_874356_1	1288494.EBAPG3_22130	3.12e-85	266.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,372E7@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Sigma-54 interaction domain	yfhA	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_423962_1	261292.Nit79A3_1076	1.4e-58	182.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2VSJ0@28216|Betaproteobacteria,373BC@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
k59_423962_2	261292.Nit79A3_1177	5.93e-65	198.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,3735G@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_423962_3	1288494.EBAPG3_23490	3.87e-56	186.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,372DQ@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_544609_1	1499967.BAYZ01000147_gene711	1.28e-25	107.0	28K2M@1|root,2Z9RY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
k59_488402_1	1121033.AUCF01000010_gene4432	3.04e-28	115.0	COG2010@1|root,COG2010@2|Bacteria,1REKI@1224|Proteobacteria,2UA53@28211|Alphaproteobacteria,2JWXG@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_423975_1	1122138.AQUZ01000004_gene994	1.58e-12	70.5	2EXUT@1|root,33R41@2|Bacteria,2I3GV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_797219_1	1492922.GY26_04920	5e-61	203.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1J5GJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Permease	dctM	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_424012_1	1499967.BAYZ01000095_gene4203	2.63e-47	176.0	COG0642@1|root,COG3292@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,2NQMI@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c,HisKA,Hpt,PAS_3,Reg_prop,Response_reg,Y_Y_Y
k59_424022_1	292563.Cyast_1661	2.33e-14	77.8	COG3225@1|root,COG3225@2|Bacteria,1G0JN@1117|Cyanobacteria	1117|Cyanobacteria	N	transport system involved in gliding motility, auxiliary component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_260331_2	518766.Rmar_0317	2.36e-10	62.4	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,4NDWN@976|Bacteroidetes,1FIWU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_797266_1	1266925.JHVX01000003_gene414	7.18e-191	557.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,372UR@32003|Nitrosomonadales	28216|Betaproteobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_797266_2	62928.azo1518	3.04e-91	271.0	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,2VIA2@28216|Betaproteobacteria,2KW4Q@206389|Rhodocyclales	206389|Rhodocyclales	A	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
k59_797266_3	266264.Rmet_2575	0.000229	43.1	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,1K0JS@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Peptidase M48	htpX_2	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_544695_1	1265502.KB905932_gene1797	1.77e-118	363.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,4ABBZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_544699_1	1234364.AMSF01000066_gene2273	4.55e-76	244.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1X31X@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf-QO	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
k59_1030465_2	1122221.JHVI01000012_gene814	3.7e-11	65.1	COG1544@1|root,COG1544@2|Bacteria,1WJUY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
k59_260427_1	1134912.AJTV01000047_gene3499	9.81e-100	317.0	COG0457@1|root,COG1413@1|root,COG3303@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,COG3303@2|Bacteria,1MX2U@1224|Proteobacteria,2TVI2@28211|Alphaproteobacteria,36ZR3@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
k59_544782_1	945713.IALB_0217	5.57e-99	315.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1030507_1	1158146.KB907130_gene1452	1.97e-18	83.6	COG1120@1|root,COG1120@2|Bacteria,1MWPV@1224|Proteobacteria,1T1UT@1236|Gammaproteobacteria,1WYFV@135613|Chromatiales	135613|Chromatiales	HP	PFAM ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1030507_2	1266925.JHVX01000015_gene230	3.9e-39	139.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2VK1S@28216|Betaproteobacteria,372XQ@32003|Nitrosomonadales	28216|Betaproteobacteria	P	FecCD transport family	btuC	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_260457_2	196367.JNFG01000002_gene2142	1.21e-91	282.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,2WA27@28216|Betaproteobacteria,1K89J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_260457_3	279714.FuraDRAFT_2661	8.83e-67	211.0	COG2095@1|root,COG2095@2|Bacteria,1MV1C@1224|Proteobacteria,2VKRW@28216|Betaproteobacteria,2KR9I@206351|Neisseriales	206351|Neisseriales	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_544798_1	1521187.JPIM01000105_gene265	4.19e-86	263.0	COG0123@1|root,COG0123@2|Bacteria,2G89I@200795|Chloroflexi,376ST@32061|Chloroflexia	32061|Chloroflexia	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_783169_1	1266925.JHVX01000001_gene2649	1.43e-46	160.0	COG1216@1|root,COG1216@2|Bacteria,1N5DV@1224|Proteobacteria,2WB4B@28216|Betaproteobacteria,372A6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_783185_2	888050.HMPREF9004_0335	4.82e-67	218.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4D4G3@85005|Actinomycetales	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_783190_1	1163617.SCD_n00555	6.8e-27	103.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2VRDH@28216|Betaproteobacteria	28216|Betaproteobacteria	G	PTS IIA-like nitrogen-regulatory protein PtsN	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_783191_1	59374.Fisuc_2831	4.27e-30	122.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1030550_1	477184.KYC_11428	7.32e-83	262.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VK54@28216|Betaproteobacteria,3T2TW@506|Alcaligenaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_488678_1	1216976.AX27061_1104	4.45e-73	238.0	COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VKHY@28216|Betaproteobacteria,3T90F@506|Alcaligenaceae	28216|Betaproteobacteria	LV	Retron-type reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
k59_544845_1	879212.DespoDRAFT_01215	2.4e-74	235.0	COG3335@1|root,COG3335@2|Bacteria,1R1IX@1224|Proteobacteria,43DBP@68525|delta/epsilon subdivisions,2X8HP@28221|Deltaproteobacteria,2MN2B@213118|Desulfobacterales	1224|Proteobacteria	L	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
k59_797440_1	746128.CADAFUBP00004516	2.37e-25	110.0	COG3119@1|root,KOG3867@2759|Eukaryota,38DVH@33154|Opisthokonta,3NUVC@4751|Fungi,3QMMG@4890|Ascomycota,20DT3@147545|Eurotiomycetes,3S8AZ@5042|Eurotiales	4751|Fungi	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_285513_1	742159.HMPREF0004_5507	7.07e-59	194.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2VHK7@28216|Betaproteobacteria,3T1MZ@506|Alcaligenaceae	28216|Betaproteobacteria	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_797464_1	573061.Clocel_4183	6.28e-39	139.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,36EAN@31979|Clostridiaceae	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
k59_797464_2	979556.MTES_2786	4.43e-14	72.8	COG1541@1|root,COG1541@2|Bacteria,2GJC7@201174|Actinobacteria,4FM3G@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_260563_1	1158292.JPOE01000002_gene2773	2.35e-117	346.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,1KJAK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Isocitrate dehydrogenase	icd	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_797476_1	945713.IALB_1079	1.46e-124	370.0	COG1866@1|root,COG1866@2|Bacteria	2|Bacteria	H	phosphoenolpyruvate carboxykinase (ATP) activity	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_1030614_1	65497.JODV01000003_gene4681	5.55e-08	58.2	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4DYS0@85010|Pseudonocardiales	201174|Actinobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_260576_1	1449126.JQKL01000030_gene2506	2.54e-48	161.0	COG2210@1|root,COG2210@2|Bacteria,1UIFM@1239|Firmicutes,24H1I@186801|Clostridia	186801|Clostridia	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_544924_1	1366050.N234_15595	3.2e-06	49.7	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VKWQ@28216|Betaproteobacteria,1JZNW@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Class II aldolase adducin family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_544924_2	1121013.P873_08100	7.61e-56	189.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1X99Q@135614|Xanthomonadales	135614|Xanthomonadales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	-	-	-	-	-	-	-	-	-	-	POR,POR_N
k59_797499_1	269799.Gmet_2580	9.31e-101	328.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_797502_1	525260.HMPREF0276_0184	2.42e-06	55.1	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,22JWI@1653|Corynebacteriaceae	201174|Actinobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_797504_1	196367.JNFG01000199_gene3257	5.11e-24	100.0	COG1802@1|root,COG1802@2|Bacteria,1RHPF@1224|Proteobacteria,2VUU2@28216|Betaproteobacteria,1K603@119060|Burkholderiaceae	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_797504_2	477641.MODMU_4786	5.52e-16	77.8	COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria,4EVMV@85013|Frankiales	201174|Actinobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	1.1.1.203	ko:K18981	ko00053,map00053	-	R10841	RC00066	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_783334_1	1267533.KB906738_gene2392	8.98e-23	103.0	COG1538@1|root,COG1538@2|Bacteria,3Y48M@57723|Acidobacteria,2JIRF@204432|Acidobacteriia	204432|Acidobacteriia	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_285620_1	404589.Anae109_3203	6.61e-54	174.0	COG0664@1|root,COG0664@2|Bacteria,1N61M@1224|Proteobacteria,42Y1U@68525|delta/epsilon subdivisions,2WNPK@28221|Deltaproteobacteria,2YVYQ@29|Myxococcales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,cNMP_binding
k59_260686_3	1125863.JAFN01000001_gene2256	1.63e-10	60.5	COG0348@1|root,COG0348@2|Bacteria,1Q4B9@1224|Proteobacteria,42P8A@68525|delta/epsilon subdivisions,2X5EJ@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10,Fer4_5
k59_488879_1	1366050.N234_31220	4.49e-12	65.9	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria,1K1D4@119060|Burkholderiaceae	28216|Betaproteobacteria	J	promotes GTP-dependent translocation of the ribosome during translation	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_488879_2	580332.Slit_2147	1.97e-50	168.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,2VI8F@28216|Betaproteobacteria	28216|Betaproteobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_424426_1	1122925.KB895378_gene2642	2.68e-105	323.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,4HADN@91061|Bacilli,26RHN@186822|Paenibacillaceae	91061|Bacilli	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_783374_1	1120792.JAFV01000001_gene869	1.96e-96	300.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,36XE2@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Adenylylsulphate kinase	cysC	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2
k59_783383_1	1123228.AUIH01000004_gene1091	4.43e-99	310.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1XRUQ@135619|Oceanospirillales	135619|Oceanospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4,1.3.99.8	ko:K11177,ko:K16877	ko00230,ko00365,ko01100,ko01120,map00230,map00365,map01100,map01120	M00546	R01768,R02103,R02987	RC00143,RC01856	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
k59_1030753_1	1088721.NSU_4806	2.18e-81	249.0	COG1216@1|root,COG1216@2|Bacteria,1R50T@1224|Proteobacteria	1224|Proteobacteria	S	Pfam Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
k59_545062_1	883078.HMPREF9695_01862	9.74e-116	352.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,3JT9C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	TIGRFAM type I secretion membrane fusion protein, HlyD family	MA20_19340	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
k59_545062_2	1411123.JQNH01000001_gene122	4.48e-81	260.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG4618 ABC-type protease lipase transport system, ATPase and permease components	prsD	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0044464,GO:0046903,GO:0051179,GO:0051234,GO:0071944	-	ko:K12539	ko02010,map02010	M00329	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.110.3	-	-	ABC_membrane,ABC_tran
k59_285695_1	880072.Desac_0385	4.56e-65	210.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,2MRC0@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_285695_2	880072.Desac_0386	1.04e-20	90.1	COG1900@1|root,COG1900@2|Bacteria,1P1MT@1224|Proteobacteria,42M1I@68525|delta/epsilon subdivisions,2WIQ2@28221|Deltaproteobacteria,2MQT8@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
k59_488944_1	1223521.BBJX01000007_gene1433	4.54e-85	269.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,4A9VY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_797661_1	243164.DET0923	1.45e-36	128.0	COG0838@1|root,COG0838@2|Bacteria,2G71E@200795|Chloroflexi,34DCJ@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_1030813_1	1288494.EBAPG3_9660	3.31e-79	263.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,371R1@32003|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_545117_1	1123311.KB904466_gene963	3.59e-23	100.0	COG2893@1|root,COG3444@1|root,COG2893@2|Bacteria,COG3444@2|Bacteria,1TQJ4@1239|Firmicutes,4H9Z8@91061|Bacilli	91061|Bacilli	G	pts system	manL	-	2.7.1.191,2.7.1.202	ko:K02769,ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060	M00273,M00276	R02630,R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.6.1	-	-	EIIA-man,PTSIIB_sorb
k59_783464_1	330214.NIDE4028	2.11e-148	434.0	COG0443@1|root,COG0443@2|Bacteria,3J0YD@40117|Nitrospirae	40117|Nitrospirae	O	Hsp70 protein	hscA	-	-	ko:K04043,ko:K04044	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33,1.A.33.1	-	-	HSP70
k59_545149_1	754476.Q7A_1290	3.56e-153	442.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,45ZRY@72273|Thiotrichales	72273|Thiotrichales	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1036127_1	1089551.KE386572_gene574	1.11e-16	81.6	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,4BPNE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_267813_2	246194.CHY_1303	6.93e-23	99.8	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,42FYW@68295|Thermoanaerobacterales	186801|Clostridia	G	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_430701_2	83406.HDN1F_22030	5.87e-13	70.9	COG2204@1|root,COG2204@2|Bacteria,1NH9G@1224|Proteobacteria,1RRF2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
k59_1014925_1	1125863.JAFN01000001_gene841	7.39e-58	194.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,42NT5@68525|delta/epsilon subdivisions,2WIWR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	alkK	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_6718_1	56780.SYN_01461	1.06e-11	63.9	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43BPM@68525|delta/epsilon subdivisions,2X70W@28221|Deltaproteobacteria,2MSKN@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	HlyD family secretion protein	ybhG	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_6718_2	882.DVU_0126	2.96e-26	110.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria,2MA8B@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	pfam abc	-	-	-	ko:K01990,ko:K01992,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC2_membrane_3,ABC_tran
k59_920990_1	315750.BPUM_1490	1.53e-24	102.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,1ZCDY@1386|Bacillus	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
k59_920990_2	94624.Bpet3123	1.09e-66	216.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJH2@28216|Betaproteobacteria,3T55M@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_496609_1	589865.DaAHT2_1537	3.89e-85	260.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,43AEV@68525|delta/epsilon subdivisions,2X5YA@28221|Deltaproteobacteria,2MM2Q@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 2-nitropropane dioxygenase NPD	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
k59_234022_1	1220582.RRU01S_29_01180	9.59e-106	319.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria,4BP2N@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	tnp*	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_267821_1	1191523.MROS_2346	3e-55	194.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
k59_756223_1	420662.Mpe_A3418	1.53e-21	89.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,1KIUD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_756223_2	1265502.KB905956_gene144	4.55e-93	279.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,4AA16@80864|Comamonadaceae	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_496610_1	983917.RGE_02200	1.62e-75	236.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,1KIZ4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_365448_1	269798.CHU_3441	9.19e-21	97.8	COG3405@1|root,COG3405@2|Bacteria,4NIQS@976|Bacteroidetes,47X9J@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolases family 8	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Glyco_hydro_8
k59_333040_1	1120983.KB894572_gene2926	7.94e-59	194.0	COG2141@1|root,COG2141@2|Bacteria,1PFU1@1224|Proteobacteria,2VA1B@28211|Alphaproteobacteria,1JQ6W@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
k59_137326_1	945713.IALB_0831	9.8e-62	212.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
k59_365455_1	1125973.JNLC01000014_gene2505	8.34e-71	231.0	COG1548@1|root,COG1548@2|Bacteria,1RAMA@1224|Proteobacteria,2U38R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GK	TIGRFAM H4MPT-linked C1 transfer pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	Hydantoinase_A
k59_267832_1	317013.NY99_08905	1.28e-121	370.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales	135614|Xanthomonadales	S	transporter	oliA	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_626853_1	867903.ThesuDRAFT_01208	3.66e-15	74.3	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,3WDAY@538999|Clostridiales incertae sedis	186801|Clostridia	F	MafB19-like deaminase	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
k59_137327_1	710686.Mycsm_04230	4.92e-08	60.1	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,238DH@1762|Mycobacteriaceae	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_234036_1	1453501.JELR01000002_gene1306	2.87e-07	57.8	COG0265@1|root,COG0265@2|Bacteria,1PI1V@1224|Proteobacteria,1S3H8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,SidE,Trypsin_2
k59_594346_1	1288494.EBAPG3_15690	1.51e-131	384.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,372Q1@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_785670_1	1034769.KB910518_gene3349	4.22e-16	76.6	COG3415@1|root,COG3415@2|Bacteria,1VHWW@1239|Firmicutes,4I7ZS@91061|Bacilli,26YD3@186822|Paenibacillaceae	91061|Bacilli	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_785670_2	420324.KI912000_gene8132	4.05e-18	81.6	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_39298_1	1156919.QWC_06194	2.14e-36	140.0	COG1846@1|root,COG2267@1|root,COG1846@2|Bacteria,COG2267@2|Bacteria,1QXHW@1224|Proteobacteria	1224|Proteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_397315_1	224911.27353265	3.19e-53	181.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2TRKA@28211|Alphaproteobacteria,3JSZG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_39304_1	46429.BV95_01236	2.75e-12	67.4	COG1063@1|root,COG1063@2|Bacteria,1MWX0@1224|Proteobacteria,2TU6B@28211|Alphaproteobacteria,2KCXX@204457|Sphingomonadales	204457|Sphingomonadales	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_953489_1	358220.C380_01240	1.43e-108	322.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2VIVU@28216|Betaproteobacteria,4A9N6@80864|Comamonadaceae	28216|Betaproteobacteria	CH	4-hydroxybenzoate 3-monooxygenase	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
k59_692506_1	713587.THITH_07390	3.84e-114	357.0	COG0457@1|root,COG0457@2|Bacteria,1QZTW@1224|Proteobacteria,1T54Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_985698_1	1229909.NSED_09345	5.63e-41	140.0	COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
k59_985698_2	436308.Nmar_1756	3.18e-47	153.0	COG1594@1|root,arCOG00579@2157|Archaea,41SS3@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	TFIIS_C
k59_985698_3	1229909.NSED_09355	1.59e-50	160.0	COG1761@1|root,arCOG04111@2157|Archaea,41SV9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	RNA polymerase Rpb3/Rpb11 dimerisation domain	-	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
k59_985698_4	1229909.NSED_09360	8.81e-32	115.0	arCOG08749@1|root,arCOG08749@2157|Archaea,41SRV@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_300050_1	1348657.M622_06610	1.31e-76	235.0	COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,2VRHA@28216|Betaproteobacteria,2KYN1@206389|Rhodocyclales	206389|Rhodocyclales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_169974_1	648885.KB316282_gene1999	3.23e-43	152.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,1JQUR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_300052_1	1276756.AUEX01000015_gene1934	2.68e-06	48.5	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,4A9U8@80864|Comamonadaceae	28216|Betaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_300052_2	420662.Mpe_A2488	2.91e-81	245.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2VH1C@28216|Betaproteobacteria,1KJWW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_397333_1	1187851.A33M_3527	6.91e-61	199.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2TRWV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_594383_1	96561.Dole_1617	8.38e-66	220.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2MIK2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA-2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_430768_1	420662.Mpe_A3368	1.77e-35	135.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,1KJHG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_267876_1	1254432.SCE1572_19035	7.48e-17	77.0	COG0670@1|root,COG0670@2|Bacteria,1R7VN@1224|Proteobacteria,43DVQ@68525|delta/epsilon subdivisions,2WZ04@28221|Deltaproteobacteria,2Z11K@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
k59_267876_2	857087.Metme_4156	1.04e-42	150.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,1RP2I@1236|Gammaproteobacteria,1XF21@135618|Methylococcales	135618|Methylococcales	P	PFAM Bile acid sodium symporter	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_725026_1	1307759.JOMJ01000003_gene652	2.53e-40	135.0	COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,42VNQ@68525|delta/epsilon subdivisions,2WQ7J@28221|Deltaproteobacteria,2MC6I@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase, family 13	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
k59_527299_1	247633.GP2143_02095	2.49e-22	95.5	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1J5TV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	rfaC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107	Glyco_transf_9
k59_527299_2	485913.Krac_2435	9.82e-33	125.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrB	-	1.3.7.9	ko:K04109	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_725027_1	991905.SL003B_0928	1.15e-112	341.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,4BPBS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_626903_1	365046.Rta_22320	3.99e-09	58.2	COG0703@1|root,COG1396@1|root,COG0703@2|Bacteria,COG1396@2|Bacteria,1MX66@1224|Proteobacteria,2VK91@28216|Betaproteobacteria,4ABJG@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	-	-	-	ko:K15546	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31,SKI
k59_626903_2	1380394.JADL01000003_gene5165	6e-121	360.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2TQTE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	boxC	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_887574_1	443143.GM18_1078	3.84e-34	134.0	COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,42PV8@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,LapD_MoxY_N
k59_527305_2	404589.Anae109_3088	1.28e-20	84.0	2EK70@1|root,33DXD@2|Bacteria,1NA99@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_137387_1	1123368.AUIS01000019_gene1225	2.57e-67	219.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1T3CM@1236|Gammaproteobacteria,2NDP9@225057|Acidithiobacillales	225057|Acidithiobacillales	L	GIY-YIG type nucleases (URI domain)	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_756276_1	1120953.AUBH01000001_gene1117	8.57e-71	237.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,4657E@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	iSbBS512_1146.SbBS512_E0217	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_365527_1	376733.IT41_11235	6.08e-49	168.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2TQVT@28211|Alphaproteobacteria,2PUQ5@265|Paracoccus	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	dctP_1	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_397348_1	323848.Nmul_A2339	6.21e-116	343.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,372UG@32003|Nitrosomonadales	28216|Betaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_496694_1	1419583.V466_22330	1.05e-42	159.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RZD3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind
k59_430786_1	1524882.A0A076GD16_9CAUD	1.49e-41	154.0	4QGIT@10239|Viruses,4QQNT@28883|Caudovirales,4QMVR@10699|Siphoviridae	10699|Siphoviridae	S	viral capsid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_300083_1	1121875.KB907550_gene636	6.99e-130	387.0	COG2015@1|root,COG2015@2|Bacteria,4NJE2@976|Bacteroidetes	976|Bacteroidetes	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_985750_1	1121918.ARWE01000001_gene2827	1.41e-26	108.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria,43UEP@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Putative peptidoglycan binding domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_397352_1	1335757.SPICUR_06720	3.87e-50	179.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_921087_1	1121035.AUCH01000008_gene1105	2.01e-100	305.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,2KUVP@206389|Rhodocyclales	206389|Rhodocyclales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_6837_1	1219049.SP5_069_01490	5.31e-33	129.0	COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2TUXC@28211|Alphaproteobacteria,2K4Z7@204457|Sphingomonadales	204457|Sphingomonadales	KL	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
k59_39365_1	365046.Rta_28190	2.55e-19	95.9	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,4ACIR@80864|Comamonadaceae	28216|Betaproteobacteria	NU	pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
k59_496714_1	1283300.ATXB01000001_gene2253	7.22e-20	88.2	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1XG03@135618|Methylococcales	135618|Methylococcales	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_496714_2	1380394.JADL01000001_gene2098	2.09e-40	142.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,2JQMV@204441|Rhodospirillales	204441|Rhodospirillales	C	(Fe-S) oxidoreductase	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_953570_1	1122211.JMLW01000013_gene469	1.56e-09	64.7	COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,1XM0P@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
k59_202534_1	443143.GM18_1247	2.51e-12	66.6	COG2704@1|root,COG2704@2|Bacteria,1MVHH@1224|Proteobacteria,42MDH@68525|delta/epsilon subdivisions,2X5GB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Anaerobic c4-dicarboxylate membrane transporter	-	-	-	ko:K07791	-	-	-	-	ko00000,ko02000	2.A.13.1	-	-	DcuA_DcuB
k59_661030_1	1254432.SCE1572_51305	1.3e-42	150.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2YTSK@29|Myxococcales	28221|Deltaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_954645_1	768710.DesyoDRAFT_4851	1.06e-05	47.8	COG2864@1|root,COG2864@2|Bacteria,1V1XF@1239|Firmicutes,24GTD@186801|Clostridia,263XV@186807|Peptococcaceae	186801|Clostridia	C	PFAM Cytochrome b(N-terminal) b6 petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_757066_1	866536.Belba_3296	6.43e-21	101.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47Y22@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_203534_1	1245469.S58_43880	9.42e-47	164.0	COG2173@1|root,COG2173@2|Bacteria,1RBFI@1224|Proteobacteria,2UHKM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	D-ala-D-ala dipeptidase	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
k59_203534_2	911045.PSE_4619	1.51e-178	512.0	COG0591@1|root,COG0591@2|Bacteria,1MVBV@1224|Proteobacteria,2UEGG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_366568_1	1028800.RG540_PA09910	4.49e-29	108.0	COG0309@1|root,COG0309@2|Bacteria,1RDJ4@1224|Proteobacteria,2U7HE@28211|Alphaproteobacteria,4BH8K@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Transposase DDE domain	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
k59_366568_2	1187851.A33M_1286	2.35e-34	120.0	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2UAE0@28211|Alphaproteobacteria,3FEDB@34008|Rhodovulum	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
k59_105777_1	382464.ABSI01000013_gene1870	1.58e-51	182.0	COG5000@1|root,COG5000@2|Bacteria,46V9C@74201|Verrucomicrobia	74201|Verrucomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_922193_1	420662.Mpe_A2209	1.88e-72	233.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,2VHJN@28216|Betaproteobacteria,1KKGB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	L-lactate permease	lldP	-	-	ko:K00427,ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14,2.A.14.1.1	-	-	Lactate_perm
k59_954660_1	1504981.KO116_0737	2.62e-24	97.1	COG1280@1|root,COG1280@2|Bacteria,1R4PK@1224|Proteobacteria,1S500@1236|Gammaproteobacteria,1XPDQ@135619|Oceanospirillales	135619|Oceanospirillales	E	Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_954660_2	1230476.C207_05092	3.13e-19	88.6	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TT05@28211|Alphaproteobacteria,3JS8N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
k59_661054_1	1162668.LFE_1326	1.22e-139	407.0	COG2801@1|root,COG2801@2|Bacteria,3J1E8@40117|Nitrospirae	2|Bacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_366573_1	436308.Nmar_0805	3.48e-98	286.0	COG0091@1|root,arCOG04098@2157|Archaea,41SJ4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_138490_1	367336.OM2255_05020	2.72e-30	115.0	2BBKE@1|root,33TKD@2|Bacteria,1NRG3@1224|Proteobacteria,2UPJY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_832696_1	1121939.L861_23765	4.84e-94	288.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1XHYF@135619|Oceanospirillales	135619|Oceanospirillales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_16227_3	936455.KI421499_gene213	7.67e-23	100.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
k59_1019751_1	76114.ebA7002	2.03e-112	343.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,2KYHA@206389|Rhodocyclales	206389|Rhodocyclales	F	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	-	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	DUF3416
k59_342200_1	987059.RBXJA2T_18011	6.31e-09	55.8	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2VH8A@28216|Betaproteobacteria,1KJU7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_342200_2	887898.HMPREF0551_0952	4.62e-89	270.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,1K0QT@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_505963_1	471881.PROPEN_04511	9.37e-50	166.0	COG0231@1|root,COG0231@2|Bacteria,1NWY9@1224|Proteobacteria,1RQ0N@1236|Gammaproteobacteria,3Z26F@583|Proteus	1236|Gammaproteobacteria	J	Elongation factor P (EF-P) OB domain	yeiP	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_404842_1	292415.Tbd_1369	9.23e-137	398.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,2VPWJ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	sulfite reductase, dissimilatory-type alpha subunit	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_308532_1	518766.Rmar_1758	3.96e-20	95.1	COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,4P230@976|Bacteroidetes	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,STN,TonB_dep_Rec
k59_374334_1	203122.Sde_2960	6.92e-62	213.0	COG0457@1|root,COG4105@1|root,COG0457@2|Bacteria,COG4105@2|Bacteria,1QX0H@1224|Proteobacteria,1T32E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_896261_1	1158345.JNLL01000001_gene1255	4.75e-23	97.8	COG0243@1|root,COG0243@2|Bacteria,2G4F5@200783|Aquificae	200783|Aquificae	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.7.2	ko:K00367,ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530,M00531	R00791,R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_404853_2	713587.THITH_07830	1.59e-34	119.0	COG2512@1|root,COG2512@2|Bacteria	2|Bacteria	T	Transcriptional regulator	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,DUF977,Fic,HATPase_c_4
k59_113916_1	1163408.UU9_16426	1.28e-60	195.0	COG0705@1|root,COG0705@2|Bacteria,1RD88@1224|Proteobacteria,1S5NF@1236|Gammaproteobacteria,1X4YW@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_832730_1	977880.RALTA_A2884	4.5e-65	202.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,1K3MD@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	mlaD	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_146582_1	95619.PM1_0226240	1.27e-56	191.0	COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,1RQRZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Inner membrane protein involved in colicin E2 resistance	creD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06143	-	-	-	-	ko00000	-	-	-	CreD
k59_930480_1	1163409.UUA_11273	2.6e-23	101.0	2E4BS@1|root,32Z7C@2|Bacteria,1NBM8@1224|Proteobacteria,1T50K@1236|Gammaproteobacteria,1X8D0@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_788883_1	1122990.BAJH01000003_gene508	1.13e-14	68.6	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP2	-	-	ko:K02078,ko:K14669	-	-	-	-	ko00000,ko00001,ko01008	-	-	-	PP-binding
k59_788883_2	269798.CHU_2122	6.05e-36	132.0	COG4261@1|root,COG4261@2|Bacteria,4NF49@976|Bacteroidetes,47PF5@768503|Cytophagia	976|Bacteroidetes	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
k59_896279_1	326427.Cagg_1577	1.81e-108	331.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_374353_1	1279009.ADICEAN_02606	4.75e-26	105.0	COG1877@1|root,COG1877@2|Bacteria,4NPCQ@976|Bacteroidetes,47TCW@768503|Cytophagia	976|Bacteroidetes	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Trehalose_PPase
k59_374353_2	1232410.KI421426_gene1372	2.45e-94	301.0	COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,42Q4Z@68525|delta/epsilon subdivisions,2WM28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase
k59_16282_1	666685.R2APBS1_0809	2.56e-30	120.0	COG0577@1|root,COG0577@2|Bacteria,1QB7S@1224|Proteobacteria,1SX7W@1236|Gammaproteobacteria,1X5XD@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_763872_1	296591.Bpro_2127	9.23e-14	73.6	COG3181@1|root,COG3181@2|Bacteria,1NEU9@1224|Proteobacteria,2VHYX@28216|Betaproteobacteria,4AC1P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_763872_2	314278.NB231_00265	7.33e-101	301.0	COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,1RS83@1236|Gammaproteobacteria,1X0JC@135613|Chromatiales	135613|Chromatiales	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_274395_1	247490.KSU1_C1435	4.01e-63	211.0	COG1752@1|root,COG1752@2|Bacteria,2J4RT@203682|Planctomycetes	203682|Planctomycetes	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_734618_1	1288494.EBAPG3_29000	1.25e-70	231.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,371PW@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Peptidase M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_994700_1	1229909.NSED_04515	2.32e-56	181.0	COG5491@1|root,arCOG00452@2157|Archaea,41T30@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_994700_2	1229909.NSED_04510	3.72e-26	98.2	arCOG08722@1|root,arCOG08722@2157|Archaea,41SSI@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_603570_1	525897.Dbac_3444	2.47e-34	135.0	COG0574@1|root,COG0745@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,COG0784@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2M7TZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2,PPDK_N
k59_241655_1	96561.Dole_0502	1.97e-42	142.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,42SST@68525|delta/epsilon subdivisions,2WPWN@28221|Deltaproteobacteria,2MK4F@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM PTS system fructose subfamily IIA component	-	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
k59_241655_2	1227352.C173_05731	1.42e-17	82.4	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4HIKU@91061|Bacilli,26RAQ@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
k59_241655_3	1121422.AUMW01000008_gene496	1.36e-16	78.2	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia	186801|Clostridia	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_274397_1	748247.AZKH_3509	2.5e-54	178.0	COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,2VHR3@28216|Betaproteobacteria,2KUVX@206389|Rhodocyclales	206389|Rhodocyclales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_963078_1	1121382.JQKG01000005_gene3361	1.23e-16	81.3	COG1392@1|root,COG1392@2|Bacteria,1WMGN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_963078_2	1121440.AUMA01000009_gene617	6.88e-49	165.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42Q5K@68525|delta/epsilon subdivisions,2X5HI@28221|Deltaproteobacteria,2M950@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_48461_1	1191523.MROS_1039	2.84e-82	262.0	COG0187@1|root,COG0187@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_603574_1	941770.GL622178_gene394	8.87e-17	86.7	COG0477@1|root,COG2814@2|Bacteria,1VSW8@1239|Firmicutes,4HUQC@91061|Bacilli,3F4AW@33958|Lactobacillaceae	91061|Bacilli	EGP	Major Facilitator	mdr	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_571313_1	1459636.NTE_02737	1.02e-84	262.0	COG0470@1|root,arCOG00469@2157|Archaea,41SFJ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Replication factor C	-	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	DNA_pol3_delta2,Rep_fac_C,RuvB_N
k59_81671_1	96561.Dole_0673	2.86e-08	55.1	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_931582_1	1123073.KB899244_gene406	5.17e-29	118.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1S1HS@1236|Gammaproteobacteria,1X48P@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_17340_1	519989.ECTPHS_14004	5.73e-78	248.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_532571_1	1218076.BAYB01000011_gene2169	2.23e-35	134.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,1K3DK@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pykA	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_532571_2	261292.Nit79A3_0457	1.41e-134	390.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,3727W@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_212523_1	443598.AUFA01000001_gene1366	9.74e-46	159.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,3JWFY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	MA20_23235	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_309525_1	1336249.JADW01000002_gene4300	1.15e-05	54.7	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,4BAHT@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_375410_1	439235.Dalk_0052	3.48e-45	166.0	COG0531@1|root,COG3064@1|root,COG0531@2|Bacteria,COG3064@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
k59_82719_1	1454004.AW11_00136	1.09e-58	194.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,1KQMM@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsB	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_242531_1	395493.BegalDRAFT_3267	7.81e-114	353.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,4604N@72273|Thiotrichales	72273|Thiotrichales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_703329_1	105559.Nwat_1005	3.24e-15	75.1	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WW9R@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_703329_2	195522.BD01_1397	9.4e-17	82.8	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,243A6@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
k59_703329_3	1123393.KB891326_gene142	6.22e-18	78.2	COG1436@1|root,COG1436@2|Bacteria,1MZUE@1224|Proteobacteria,2W5EY@28216|Betaproteobacteria	28216|Betaproteobacteria	C	ATP synthase (F/14-kDa) subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_F
k59_637041_1	1121405.dsmv_1604	6.26e-109	321.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,2MJ3P@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_670491_1	1396141.BATP01000003_gene5142	1.49e-51	186.0	COG4625@1|root,COG5492@1|root,COG4625@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	PATR,Peptidase_S8
k59_147745_1	756067.MicvaDRAFT_4834	9.83e-33	130.0	COG0488@1|root,COG0488@2|Bacteria,1G0I1@1117|Cyanobacteria,1H6YE@1150|Oscillatoriales	1117|Cyanobacteria	S	of ABC transporters with duplicated ATPase	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_604634_1	1173028.ANKO01000135_gene2502	1.27e-42	155.0	COG3957@1|root,COG3957@2|Bacteria,1G23D@1117|Cyanobacteria,1H8NV@1150|Oscillatoriales	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	-	-	-	-	-	-	-	-	-	-	XFP,XFP_N
k59_604634_2	1198452.Jab_2c24780	1.99e-09	58.2	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,472SY@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	helix_turn_helix isocitrate lyase regulation	yiaJ	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_17363_1	91464.S7335_3946	3.84e-20	84.3	COG0776@1|root,COG0776@2|Bacteria,1G7ER@1117|Cyanobacteria,1H0RE@1129|Synechococcus	1117|Cyanobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	himA	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_17363_2	640081.Dsui_1701	7.33e-16	74.3	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2VKQH@28216|Betaproteobacteria,2KW5S@206389|Rhodocyclales	206389|Rhodocyclales	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_49534_1	261292.Nit79A3_0643	1.85e-97	289.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,3721M@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_49534_2	1121035.AUCH01000005_gene165	1.26e-19	81.6	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2VU9V@28216|Betaproteobacteria,2KWQT@206389|Rhodocyclales	206389|Rhodocyclales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_897260_1	56780.SYN_01884	3.89e-16	73.9	COG0741@1|root,COG0741@2|Bacteria,1MZU4@1224|Proteobacteria,42TN1@68525|delta/epsilon subdivisions,2WQMG@28221|Deltaproteobacteria,2MS2B@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	C-type lysozyme/alpha-lactalbumin family	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_931636_1	330214.NIDE2927	2.12e-24	100.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3J0AI@40117|Nitrospirae	40117|Nitrospirae	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_931636_2	330214.NIDE2926	5.4e-87	268.0	COG2812@1|root,COG2812@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_833889_1	1485544.JQKP01000014_gene1886	8.8e-132	381.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,44V3M@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_405869_1	1403819.BATR01000079_gene2273	1.72e-70	241.0	28I8X@1|root,2Z8BQ@2|Bacteria,46V28@74201|Verrucomicrobia,2IVQE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_115047_1	929556.Solca_2697	6.77e-37	135.0	COG2755@1|root,COG2755@2|Bacteria,4NPB3@976|Bacteroidetes,1ISEG@117747|Sphingobacteriia	976|Bacteroidetes	E	PFAM GDSL-like Lipase Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_637066_2	706587.Desti_5204	4.85e-116	337.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2WIPU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_703360_2	520999.PROVALCAL_01877	7.81e-34	124.0	2AGTB@1|root,3171D@2|Bacteria,1RJGM@1224|Proteobacteria,1S6XK@1236|Gammaproteobacteria,3ZA1Y@586|Providencia	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2833
k59_56920_2	1232410.KI421421_gene3650	9.97e-35	135.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WTUB@28221|Deltaproteobacteria,43T1I@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	General secretory system II, protein E domain protein	pulE-1	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_351078_1	386456.JQKN01000010_gene678	1.36e-10	61.6	COG1131@1|root,arCOG00196@2157|Archaea,2Y7W4@28890|Euryarchaeota	28890|Euryarchaeota	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_351078_2	706587.Desti_3167	1.7e-70	222.0	COG4177@1|root,COG4177@2|Bacteria,1NNMV@1224|Proteobacteria,42PQV@68525|delta/epsilon subdivisions,2WJDV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_842034_1	1163617.SCD_n01575	2.3e-51	183.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_515104_1	242159.ABO97762	7.64e-07	52.4	COG0123@1|root,KOG1343@2759|Eukaryota,37N54@33090|Viridiplantae,34JFX@3041|Chlorophyta	3041|Chlorophyta	B	histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_743843_1	1380358.JADJ01000011_gene192	1.7e-18	88.2	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1XKC6@135619|Oceanospirillales	135619|Oceanospirillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_477705_1	1028307.EAE_08535	2.99e-81	259.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,3X22K@547|Enterobacter	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF2	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_873070_1	292415.Tbd_1140	6.18e-78	239.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,1KRM4@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	-	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_873070_2	85643.Tmz1t_1741	0.000128	42.4	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2VU0P@28216|Betaproteobacteria,2KWZZ@206389|Rhodocyclales	206389|Rhodocyclales	U	preprotein translocase	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
k59_448248_1	1123367.C666_02410	5.73e-95	288.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VIEP@28216|Betaproteobacteria,2KVDP@206389|Rhodocyclales	206389|Rhodocyclales	E	PFAM Aminotransferase class I and II	dapC	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_939655_1	330214.NIDE3876	1.63e-16	74.3	COG4980@1|root,COG4980@2|Bacteria,3J1B3@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
k59_939655_2	330214.NIDE4060	2.21e-120	352.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_249429_1	994479.GL877878_gene2110	2.67e-11	63.5	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4E1MA@85010|Pseudonocardiales	201174|Actinobacteria	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_249429_2	1229780.BN381_650002	7.44e-33	124.0	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_580497_1	485918.Cpin_1093	9.27e-33	131.0	COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,1IPI4@117747|Sphingobacteriia	976|Bacteroidetes	S	ABC transporter	yfmR	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1003352_1	1123367.C666_00120	4.38e-86	271.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,2KUFR@206389|Rhodocyclales	206389|Rhodocyclales	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
k59_382734_1	397945.Aave_0771	8.33e-53	178.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,2VHWB@28216|Betaproteobacteria,4AAF4@80864|Comamonadaceae	28216|Betaproteobacteria	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
k59_122852_1	747365.Thena_0598	9.84e-13	67.4	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,42F1X@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_122852_2	644968.DFW101_2720	1.84e-13	70.5	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,2MC00@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_56949_1	502025.Hoch_5150	3.6e-63	218.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42Q10@68525|delta/epsilon subdivisions,2WM5I@28221|Deltaproteobacteria,2YTSD@29|Myxococcales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3372)	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	CBM_48,DUF3372
k59_515119_1	93220.LV28_11170	2.49e-44	163.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,1JZN8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	ribonuclease II	rnb	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
k59_644816_1	1216932.CM240_1328	3.27e-05	51.6	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,36DK9@31979|Clostridiaceae	186801|Clostridia	L	snf2 family	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
k59_873080_1	1123503.KB908058_gene956	7.3e-11	66.2	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2KF74@204458|Caulobacterales	204458|Caulobacterales	O	Belongs to the peptidase S1C family	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_155612_2	1232437.KL662036_gene2708	6.77e-43	143.0	COG0748@1|root,COG0748@2|Bacteria,1N2JV@1224|Proteobacteria,42TYW@68525|delta/epsilon subdivisions,2WQEM@28221|Deltaproteobacteria,2MK6D@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_644820_1	1128421.JAGA01000002_gene1860	1.43e-69	225.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	KR,p450
k59_1024152_1	365046.Rta_24760	1.66e-107	316.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria,4AA2I@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protocatechuate 4,5-dioxygenase	ligB	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
k59_155613_1	582899.Hden_0690	5.53e-61	200.0	COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_155613_2	582899.Hden_0689	1.12e-126	363.0	COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,2U2FE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
k59_155614_1	765911.Thivi_0478	1.77e-46	159.0	COG3039@1|root,COG3039@2|Bacteria,1N88K@1224|Proteobacteria	1224|Proteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
k59_220170_1	251221.35214446	1.13e-48	162.0	COG2813@1|root,COG2813@2|Bacteria,1GQE6@1117|Cyanobacteria	1117|Cyanobacteria	J	Protein of unknown function (DUF938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF938
k59_580519_1	1163617.SCD_n00479	6.29e-93	289.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_515139_1	1454004.AW11_02855	1.87e-80	253.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2VPQP@28216|Betaproteobacteria	28216|Betaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_536431_1	671143.DAMO_1605	2.18e-54	174.0	COG0377@1|root,COG0377@2|Bacteria,2NP84@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_1024634_1	1005994.GTGU_04125	3.53e-24	97.8	COG3409@1|root,COG3409@2|Bacteria,1R4RS@1224|Proteobacteria,1S346@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAP
k59_1024634_2	1052684.PPM_3263	1.99e-07	53.1	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	PPC,Peptidase_C14,Sel1
k59_679633_1	1168065.DOK_15893	3.55e-31	122.0	COG0204@1|root,COG0204@2|Bacteria,1RF5A@1224|Proteobacteria,1SJVY@1236|Gammaproteobacteria,1J87K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_156526_1	1299327.I546_0751	2.46e-67	218.0	COG1321@1|root,COG1321@2|Bacteria	2|Bacteria	K	iron dependent repressor	nagC	-	-	ko:K02003,ko:K02565,ko:K15545	-	M00258	-	-	ko00000,ko00002,ko02000,ko03000	3.A.1	-	-	HTH_IclR,MarR,ROK
k59_613373_1	1528106.JRJE01000025_gene83	3.02e-41	143.0	COG3090@1|root,COG3090@2|Bacteria,1N0N7@1224|Proteobacteria,2U65H@28211|Alphaproteobacteria,2JX9C@204441|Rhodospirillales	204441|Rhodospirillales	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_613373_2	411902.CLOBOL_06140	2.59e-06	50.4	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,21ZGS@1506553|Lachnoclostridium	1239|Firmicutes	G	COG COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_973293_1	394.NGR_c06170	2.45e-18	85.1	COG1802@1|root,COG1802@2|Bacteria,1RDIT@1224|Proteobacteria,2U7YZ@28211|Alphaproteobacteria,4BACI@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_581478_2	159087.Daro_1782	1.6e-50	166.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,2KWDE@206389|Rhodocyclales	206389|Rhodocyclales	H	molybdopterin-guanine dinucleotide biosynthesis protein	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
k59_712421_1	414996.IL38_11625	4.67e-82	258.0	COG0620@1|root,COG0620@2|Bacteria,2H8H4@201174|Actinobacteria,4084I@622450|Actinopolysporales	201174|Actinobacteria	E	Cobalamin-independent synthase, Catalytic domain	metE2	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_712421_2	1000565.METUNv1_01460	1.97e-29	108.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
k59_221062_1	1485544.JQKP01000011_gene714	8.62e-56	193.0	28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,2VK1A@28216|Betaproteobacteria,44WD5@713636|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_413595_1	338963.Pcar_0447	5.46e-07	50.4	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,43S5W@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_413595_2	1304885.AUEY01000053_gene152	3.14e-44	149.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MK72@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_383665_1	1458427.BAWN01000011_gene676	8.8e-22	93.2	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,4AD0Z@80864|Comamonadaceae	28216|Betaproteobacteria	G	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_383665_2	765914.ThisiDRAFT_1623	2.11e-63	195.0	COG4451@1|root,COG4451@2|Bacteria,1R9ZE@1224|Proteobacteria,1S3XZ@1236|Gammaproteobacteria,1X23Q@135613|Chromatiales	135613|Chromatiales	C	PFAM Ribulose bisphosphate carboxylase, small chain	-	-	4.1.1.39	ko:K01602	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_small
k59_383665_3	1288494.EBAPG3_470	4.05e-62	197.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria,37260@32003|Nitrosomonadales	28216|Betaproteobacteria	S	CbbQ/NirQ/NorQ C-terminal	cbbQ	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_317503_1	330214.NIDE4386	4.26e-123	368.0	COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae	40117|Nitrospirae	CP	NADH-quinone oxidoreductase	-	-	1.6.5.3	ko:K00341,ko:K05577	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_744858_2	1461694.ATO9_10075	9.9e-46	160.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2PD71@252301|Oceanicola	28211|Alphaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_123812_1	640081.Dsui_2139	3.36e-13	69.7	2AM41@1|root,31BY6@2|Bacteria,1RHP5@1224|Proteobacteria,2VSXQ@28216|Betaproteobacteria,2KWPH@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF3348)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3348
k59_123812_2	381666.H16_B0520	4.58e-29	117.0	COG1511@1|root,COG1511@2|Bacteria,1QTXE@1224|Proteobacteria,2WGGR@28216|Betaproteobacteria,1K38B@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF802)	-	-	-	-	-	-	-	-	-	-	-	-	DUF802
k59_973317_1	323848.Nmul_A0210	9.47e-75	238.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,37240@32003|Nitrosomonadales	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_250297_1	1437824.BN940_06656	1.96e-71	226.0	COG4977@1|root,COG4977@2|Bacteria,1QZKA@1224|Proteobacteria,2WHMM@28216|Betaproteobacteria,3T9K9@506|Alcaligenaceae	28216|Betaproteobacteria	K	AraC-like ligand binding domain	-	-	-	ko:K18954	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18
k59_516129_1	207559.Dde_1183	6.5e-86	261.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,43B4R@68525|delta/epsilon subdivisions,2X5VN@28221|Deltaproteobacteria,2MGWB@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_449192_1	1454004.AW11_02850	2.92e-38	132.0	COG1320@1|root,COG1320@2|Bacteria	2|Bacteria	P	monovalent cation:proton antiporter activity	mnhG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_449192_2	1150469.RSPPHO_02866	4.91e-26	99.4	COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,2UHB7@28211|Alphaproteobacteria,2JU0Y@204441|Rhodospirillales	204441|Rhodospirillales	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_449192_3	1122613.ATUP01000001_gene2297	1.96e-13	69.3	COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,2UBYN@28211|Alphaproteobacteria,43Y84@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	COG1863 Multisubunit Na H antiporter, MnhE subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_156555_1	981223.AIED01000057_gene2655	3.14e-40	149.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae	1236|Gammaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_383672_1	1229204.AMYY01000006_gene1154	1.43e-15	81.6	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,4BPX9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Tetratricopeptide repeats	MA20_42300	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
k59_188565_1	999541.bgla_1g11060	5.46e-37	142.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1K01Y@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K02021,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_940656_1	566466.NOR53_1301	6.14e-15	78.6	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,1J5WE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
k59_156557_1	335543.Sfum_3758	2.82e-93	285.0	COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_221091_1	945713.IALB_1518	4.09e-131	378.0	COG2089@1|root,COG2089@2|Bacteria	2|Bacteria	M	N-acylneuraminate-9-phosphate synthase activity	neuB	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3,NeuB
k59_383683_1	204669.Acid345_2146	2.21e-23	103.0	COG1305@1|root,COG1305@2|Bacteria,3Y5BT@57723|Acidobacteria	57723|Acidobacteria	E	Domain of unknown function (DUF3488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
k59_712448_1	85643.Tmz1t_0094	2.28e-105	317.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,2KVNV@206389|Rhodocyclales	206389|Rhodocyclales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_712448_2	765911.Thivi_3198	1.74e-34	124.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales	135613|Chromatiales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_581516_1	1454004.AW11_02738	2.41e-88	270.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,2VHF0@28216|Betaproteobacteria,1KQMR@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_188580_1	391735.Veis_0110	8.44e-103	310.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2WFJM@28216|Betaproteobacteria,4AD19@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_221097_1	240016.ABIZ01000001_gene5535	1.09e-98	306.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_449216_1	640081.Dsui_0290	3.62e-88	276.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VHP4@28216|Betaproteobacteria,2KUSH@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_383690_1	264198.Reut_A2745	9.57e-73	243.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,1K19S@119060|Burkholderiaceae	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_874054_1	358220.C380_06100	2.45e-105	312.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,4ABHU@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_57920_1	1045855.DSC_10860	2.57e-09	56.6	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1X7IW@135614|Xanthomonadales	135614|Xanthomonadales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_772881_1	41875.XP_007508262.1	6.88e-83	264.0	COG1012@1|root,KOG2451@2759|Eukaryota,37KPW@33090|Viridiplantae,34K7P@3041|Chlorophyta	3041|Chlorophyta	C	Aldehyde dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_712466_1	1232410.KI421426_gene1372	4.37e-45	165.0	COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,42Q4Z@68525|delta/epsilon subdivisions,2WM28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase
k59_940688_1	1094184.KWO_0108420	3.28e-05	48.9	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN9J@1236|Gammaproteobacteria,1X3AX@135614|Xanthomonadales	135614|Xanthomonadales	M	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_940688_2	1266925.JHVX01000003_gene444	2.06e-12	67.8	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,3727K@32003|Nitrosomonadales	28216|Betaproteobacteria	V	Hydrophobe amphiphile efflux-1 HAE1	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_317542_1	457424.BFAG_04163	4.08e-05	51.6	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_772884_1	105559.Nwat_1288	1.61e-80	261.0	COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,1RZPU@1236|Gammaproteobacteria,1WW3K@135613|Chromatiales	135613|Chromatiales	G	PFAM Amylo-alpha-16-glucosidase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	GDE_C,GDE_N
k59_780916_1	159087.Daro_3414	5.38e-54	184.0	COG2114@1|root,COG2114@2|Bacteria,1QWGZ@1224|Proteobacteria,2WEJJ@28216|Betaproteobacteria,2KZV9@206389|Rhodocyclales	206389|Rhodocyclales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
k59_542379_2	1255043.TVNIR_0889	3.92e-07	55.5	COG2199@1|root,COG2703@1|root,COG2703@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1S5H1@1236|Gammaproteobacteria,1X16Q@135613|Chromatiales	135613|Chromatiales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_421620_1	1457250.BBMO01000001_gene1293	7.97e-12	70.1	COG2513@1|root,arCOG00581@2157|Archaea,2Y86J@28890|Euryarchaeota,2415K@183963|Halobacteria	183963|Halobacteria	G	COG2513 PEP phosphonomutase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_780938_1	395495.Lcho_3893	4.55e-64	220.0	COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_258211_2	1123367.C666_08705	1.35e-63	207.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,2KV8I@206389|Rhodocyclales	206389|Rhodocyclales	CI	Bifunctional enoyl-CoA hydratase phosphate acetyltransferase	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_780952_1	1121438.JNJA01000001_gene2436	2.61e-29	112.0	COG0730@1|root,COG0730@2|Bacteria,1NX2Y@1224|Proteobacteria,42P1U@68525|delta/epsilon subdivisions,2WJZV@28221|Deltaproteobacteria,2M8ZG@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_780952_2	1121438.JNJA01000001_gene2437	1.97e-36	125.0	2DYSQ@1|root,32V5Z@2|Bacteria,1NKWT@1224|Proteobacteria,42X9J@68525|delta/epsilon subdivisions,2WSYE@28221|Deltaproteobacteria,2MCRC@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_796400_1	1288494.EBAPG3_17910	0.0	1340.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,371SW@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_796400_2	1071679.BG57_17675	5.9e-17	79.7	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,1JZXX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_421659_1	338969.Rfer_2227	7.15e-71	242.0	COG0457@1|root,COG1396@1|root,COG3899@1|root,COG0457@2|Bacteria,COG1396@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,4AF3Y@80864|Comamonadaceae	28216|Betaproteobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
k59_1029384_1	1123008.KB905696_gene2784	2.09e-09	62.0	COG0484@1|root,COG0484@2|Bacteria,4NF41@976|Bacteroidetes,2FPHH@200643|Bacteroidia,22WBJ@171551|Porphyromonadaceae	976|Bacteroidetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_780976_1	41431.PCC8801_0566	1.66e-11	72.8	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	DUF3662,FHA,Yop-YscD_cpl
k59_326387_1	859653.HIMB5_00004980	2.57e-106	324.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2TSN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase fumarate reductase, flavoprotein subunit	MA20_14860	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_326389_1	261292.Nit79A3_0357	3.75e-33	121.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,372WD@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_326389_2	1163617.SCD_n02454	1.07e-16	74.7	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,2VUVV@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
k59_421676_1	709797.CSIRO_1637	2.24e-108	323.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3JTXU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_30170	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_780984_2	292415.Tbd_2103	3.66e-40	135.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2VTWT@28216|Betaproteobacteria,1KRUP@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Ribosomal protein S18	-	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_800717_2	1408254.T458_23795	6.03e-07	54.7	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
k59_800728_1	671143.DAMO_0393	1.06e-80	262.0	COG0507@1|root,COG0507@2|Bacteria,2NNQY@2323|unclassified Bacteria	2|Bacteria	L	Helix-hairpin-helix containing domain	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_288584_2	330214.NIDE3365	7.49e-43	159.0	COG0683@1|root,COG0683@2|Bacteria,3J18U@40117|Nitrospirae	40117|Nitrospirae	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_547966_1	765911.Thivi_2540	7.68e-96	293.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_547975_1	323848.Nmul_A0098	1.14e-61	200.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,371MS@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
k59_288617_1	397945.Aave_1490	2.1e-57	197.0	COG3300@1|root,COG5001@1|root,COG3300@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4ACAD@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	gmr	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,MHYT
k59_288622_1	1499967.BAYZ01000073_gene2049	2.39e-16	82.8	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,Sulfatase
k59_1033028_1	1121904.ARBP01000002_gene6719	2.36e-65	211.0	COG1216@1|root,COG1216@2|Bacteria,4NIW6@976|Bacteroidetes,47PUF@768503|Cytophagia	976|Bacteroidetes	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_800791_1	1286093.C266_13279	2.02e-07	52.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1JZPR@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_800798_1	391625.PPSIR1_10030	6.43e-76	242.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2YUJG@29|Myxococcales	28221|Deltaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_548061_1	1236959.BAMT01000001_gene1631	2.34e-48	167.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2WH9U@28216|Betaproteobacteria,2KME4@206350|Nitrosomonadales	206350|Nitrosomonadales	I	PFAM Carbamoyl-phosphate synthase L chain	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_800887_1	330214.NIDE2493	1.39e-120	356.0	COG1355@1|root,COG1355@2|Bacteria,3J0U4@40117|Nitrospirae	40117|Nitrospirae	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_288748_1	330214.NIDE2830	8.9e-93	293.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria	2|Bacteria	U	Type ii and iii secretion system protein	pulQ	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,STN,Secretin,Secretin_N
k59_548169_1	103733.JNYO01000008_gene5545	9.16e-12	67.0	COG3209@1|root,COG5184@1|root,COG5276@1|root,COG3209@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria,2GMBB@201174|Actinobacteria,4E3ST@85010|Pseudonocardiales	201174|Actinobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat,TIG
k59_1033207_1	397945.Aave_2023	2.97e-99	308.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,4AD7Y@80864|Comamonadaceae	28216|Betaproteobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_548219_1	1216976.AX27061_5824	2.43e-52	176.0	COG0860@1|root,COG0860@2|Bacteria,1RJBG@1224|Proteobacteria,2VS51@28216|Betaproteobacteria,3T6T6@506|Alcaligenaceae	28216|Betaproteobacteria	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
k59_288891_1	883080.HMPREF9697_03574	3.07e-65	223.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,3JR2T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
k59_801083_1	1123257.AUFV01000001_gene1822	1.66e-32	118.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,1S44Q@1236|Gammaproteobacteria,1XATE@135614|Xanthomonadales	135614|Xanthomonadales	K	NikR C terminal nickel binding domain	-	-	-	-	-	-	-	-	-	-	-	-	NikR_C,RHH_1
k59_801083_2	107636.JQNK01000009_gene3389	3.34e-12	68.2	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,36XJA@31993|Methylocystaceae	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	hupT	-	2.7.13.3	ko:K19661	ko02020,map02020	M00772	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_288898_1	252305.OB2597_06875	4.67e-35	130.0	COG0346@1|root,COG0346@2|Bacteria,1MW8Z@1224|Proteobacteria,2TS64@28211|Alphaproteobacteria,2PF1F@252301|Oceanicola	28211|Alphaproteobacteria	E	lactoylglutathione lyase activity	MA20_40050	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
k59_288899_1	1499683.CCFF01000015_gene3509	1.39e-09	64.7	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,36FU2@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	norM	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_548281_1	263358.VAB18032_13575	3.94e-33	127.0	COG1230@1|root,COG1230@2|Bacteria,2GMRZ@201174|Actinobacteria,4DBPK@85008|Micromonosporales	201174|Actinobacteria	P	cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
k59_801125_1	330214.NIDE1362	2.83e-80	263.0	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.42,2.7.7.59,2.7.7.89	ko:K00982,ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_801125_2	330214.NIDE1363	8.99e-15	72.8	COG0174@1|root,COG0174@2|Bacteria,3J0AS@40117|Nitrospirae	40117|Nitrospirae	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_288947_1	62928.azo3123	8.59e-06	50.4	COG3087@1|root,COG3087@2|Bacteria,1RCA5@1224|Proteobacteria,2VTK8@28216|Betaproteobacteria,2KWVE@206389|Rhodocyclales	206389|Rhodocyclales	D	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
k59_1033305_1	983917.RGE_40300	1.82e-37	143.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,1KJK2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	GAF domain	-	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
k59_801167_1	405948.SACE_3275	4.93e-21	95.5	COG1609@1|root,COG1609@2|Bacteria,2GK1X@201174|Actinobacteria,4DZM8@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_801195_1	483219.LILAB_25995	5.19e-34	122.0	COG2963@1|root,COG2963@2|Bacteria,1NDY6@1224|Proteobacteria,42VHR@68525|delta/epsilon subdivisions,2WSES@28221|Deltaproteobacteria,2Z3DH@29|Myxococcales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_289015_1	981085.XP_010101572.1	3.2e-35	135.0	COG0206@1|root,2QRFN@2759|Eukaryota,37J6B@33090|Viridiplantae,3G7M9@35493|Streptophyta,4JJIY@91835|fabids	35493|Streptophyta	D	Cell division protein ftsZ	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006996,GO:0008150,GO:0009507,GO:0009532,GO:0009534,GO:0009536,GO:0009570,GO:0009579,GO:0009657,GO:0009658,GO:0009987,GO:0010020,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0031976,GO:0031984,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034357,GO:0035639,GO:0036094,GO:0042651,GO:0042802,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043572,GO:0043621,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0048285,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_548365_1	1254432.SCE1572_07020	3.61e-37	138.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria	1224|Proteobacteria	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_801217_1	740709.A10D4_05462	9.82e-83	270.0	COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,1RN9S@1236|Gammaproteobacteria,2QFER@267893|Idiomarinaceae	1236|Gammaproteobacteria	P	Outer membrane receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_801260_1	1288494.EBAPG3_14640	5.52e-66	209.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,372S4@32003|Nitrosomonadales	28216|Betaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	fnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_801271_1	644282.Deba_2234	2.65e-85	264.0	COG0191@1|root,COG0191@2|Bacteria,1NMAK@1224|Proteobacteria,42NPW@68525|delta/epsilon subdivisions,2WIMN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Ketose-bisphosphate aldolase, class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_289080_2	511.JT27_19050	1.43e-18	82.8	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2VHEW@28216|Betaproteobacteria,3T2ID@506|Alcaligenaceae	28216|Betaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_289099_1	497321.C664_14579	2.27e-97	301.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,2KV9F@206389|Rhodocyclales	206389|Rhodocyclales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_289121_1	296591.Bpro_4320	2.41e-137	394.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2VIM3@28216|Betaproteobacteria,4AAJG@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM amidohydrolase 2	ligJ	-	4.1.1.46,4.2.1.83	ko:K10220,ko:K14333	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R00821,R04478	RC00390,RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_1033454_1	158500.BV97_02734	1.58e-17	80.1	2D71I@1|root,32TN6@2|Bacteria,1NAYY@1224|Proteobacteria,2UGUK@28211|Alphaproteobacteria,2KAQ5@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_289156_1	1416759.AYMR01000026_gene3450	1.1e-05	53.9	COG2843@1|root,COG4763@1|root,COG2843@2|Bacteria,COG4763@2|Bacteria,2IT9Y@201174|Actinobacteria,4FPTV@85023|Microbacteriaceae	201174|Actinobacteria	M	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3,PGA_cap
k59_548507_1	1434929.X946_2265	3.1e-106	322.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VIYI@28216|Betaproteobacteria,1KH1C@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
k59_548543_1	720554.Clocl_1367	7.04e-57	195.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3WI99@541000|Ruminococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	EAL,GGDEF,SBP_bac_3
k59_289222_1	640081.Dsui_0427	2.52e-24	100.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VHDY@28216|Betaproteobacteria,2KV0M@206389|Rhodocyclales	206389|Rhodocyclales	C	NADH flavin	abmA	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
k59_289222_2	1121861.KB899929_gene315	3.75e-18	82.4	2BZ0R@1|root,2Z7U0@2|Bacteria,1MX37@1224|Proteobacteria	1224|Proteobacteria	S	Nitrile hydratase	nthA	-	4.2.1.84	ko:K01721,ko:K20807	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R02828,R04020,R05379,R05596,R07780,R07854	RC00483,RC00792,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_alpha,NHase_beta
k59_548556_1	339670.Bamb_5782	2.74e-89	277.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VZ6E@28216|Betaproteobacteria,1K0K8@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_801461_1	1121928.AUHE01000012_gene1442	8.9e-06	47.4	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4GAD2@85026|Gordoniaceae	201174|Actinobacteria	T	Tyrosine phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
k59_801461_2	566466.NOR53_517	8.43e-48	163.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Phenol_MetA_deg,Toluene_X
k59_289267_1	1485544.JQKP01000001_gene915	6.54e-38	133.0	COG2413@1|root,COG2413@2|Bacteria,1RFTH@1224|Proteobacteria,2VJC9@28216|Betaproteobacteria,44VRE@713636|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_289267_2	1163617.SCD_n02940	3.06e-84	272.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Penicillin-binding Protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_289273_1	1123393.KB891317_gene2209	4.45e-06	45.8	COG0662@1|root,COG0662@2|Bacteria,1QW6S@1224|Proteobacteria	1224|Proteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_289273_2	1230342.CTM_04520	2.05e-40	140.0	COG0454@1|root,COG0456@2|Bacteria,1VC1N@1239|Firmicutes,24MWN@186801|Clostridia,36V25@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
k59_1033578_1	349124.Hhal_2127	3.69e-07	49.3	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1WYWY@135613|Chromatiales	135613|Chromatiales	J	Sigma 54 modulation protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_1033578_2	1131553.JIBI01000041_gene1993	3.16e-77	233.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2VRDH@28216|Betaproteobacteria,372H5@32003|Nitrosomonadales	28216|Betaproteobacteria	GT	PTS IIA-like nitrogen-regulatory protein PtsN	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_801519_1	436308.Nmar_0467	2.92e-85	265.0	arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_548634_1	671143.DAMO_1514	1.67e-52	176.0	COG1806@1|root,COG1806@2|Bacteria,2NRN6@2323|unclassified Bacteria	2|Bacteria	S	Kinase/pyrophosphorylase	yqfL	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_548687_1	1123376.AUIU01000015_gene476	1.78e-36	137.0	COG0142@1|root,COG0142@2|Bacteria,3J0H0@40117|Nitrospirae	40117|Nitrospirae	H	Polyprenyl synthetase	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_548694_1	316058.RPB_4416	6.97e-63	217.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,3JQT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_548712_1	323848.Nmul_A0764	3.93e-135	403.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,371Q6@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_801619_1	330214.NIDE1513	1.01e-52	173.0	COG0020@1|root,COG0020@2|Bacteria,3J0HJ@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_289384_1	321327.CYA_0128	6.8e-70	230.0	COG1166@1|root,COG1166@2|Bacteria,1G1C4@1117|Cyanobacteria,1GYFT@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_548728_1	315730.BcerKBAB4_5460	5.76e-39	147.0	COG1073@1|root,COG1073@2|Bacteria,1UJD3@1239|Firmicutes,4IT5U@91061|Bacilli,1ZKMR@1386|Bacillus	91061|Bacilli	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1033681_1	1229909.NSED_09310	2.49e-68	210.0	arCOG08765@1|root,arCOG08765@2157|Archaea,41SQJ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_548738_1	1211114.ALIP01000093_gene1748	1.36e-27	103.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1X681@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_548738_2	1046724.KB889828_gene2976	6.61e-39	136.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,1RNWU@1236|Gammaproteobacteria,467HQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_289411_1	1236541.BALL01000080_gene4994	4.98e-113	354.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1MX41@1224|Proteobacteria,1RP38@1236|Gammaproteobacteria,2Q99K@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_801693_1	1009370.ALO_19417	3.14e-45	164.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,4H77H@909932|Negativicutes	909932|Negativicutes	C	L-lactate permease	-	-	-	-	-	-	-	-	-	-	-	-	Lactate_perm
k59_289461_2	420324.KI912086_gene7328	4.74e-24	101.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,1JU3D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3,DUF1643
## 18366 queries scanned
## Total time (seconds): 94.66728615760803
## Rate: 194.01 q/s